                         SEQUENCE LISTING

<110>  BeiGene, Ltd.
 
<120>  ANTI-CEA AND ANTI-CD137 MULTISPECIFIC ANTIBODIES AND METHODS OF 
       USE

<130>  BGB25601-01PCT

<160>  358   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR1 (IMGT)

<400>  1

Gly Tyr Ile Phe Thr Ser Tyr Tyr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR2 (IMGT)

<400>  2

Ile Asn Pro Gln Thr Gly Lys Thr 
1               5               


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K/BGA13  HCDR3 (IMGT)

<400>  3

Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr 
1               5                   10              


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K LCDR1 (IMGT)

<400>  4

Glu Asn Gln Tyr Gly Tyr 
1               5       


<210>  5
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K  LCDR2 (IMGT)

<400>  5

Asn Tyr 
1       


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K LCDR3 (IMGT) or BGA113K LCDR3 (Kabat) or BGA113K LCDR3 (Chothia)

<400>  6

Gln His His Leu Gly Thr Pro Tyr Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR1 (Kabat)

<400>  7

Ser Tyr Tyr Leu His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR2 (Kabat)

<400>  8

Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR3 (Kabat) or BGA113K HCDR3 (Chothia) LCDR1 (Chothia)

<400>  9

Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K LCDR1 (Kabat) or BGA113K 

<400>  10

Arg Ala Ser Glu Asn Gln Tyr Gly Tyr Leu Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K LCDR2  (Kabat)

<400>  11

Asn Tyr Lys Asn Leu Val Glu 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR1 (Chothia

<400>  12

Gly Tyr Ile Phe Thr Ser Tyr 
1               5           


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR2 (Chothia)

<400>  13

Asn Pro Gln Thr Gly Lys 
1               5       


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K VH

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113/BGA113K VL

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Gln Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Tyr Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Leu Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  16
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA113K VH DNA

<400>  16
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360


<210>  17
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA113/BGA113K VL DNA

<400>  17
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc gcgcgagcga aaaccagtat ggctatctgg cgtggtatca gcagaaaccg      120

ggcaaagtgc cgaaactgct gatttataac tataaaaacc tggtggaagg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagatgtgg cgacctatta ttgccagcat catctgggca ccccgtatac ctttggccag      300

ggcaccaaag tggaaattaa a                                                321


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190

<400>  18

Gly Phe Thr Phe Ser Ser Phe Gly 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190  HCDR2 (IMGT)

<400>  19

Ile Ser Ile Gly Ser Asp Ile Ile 
1               5               


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR3 (IMGT)

<400>  20

Thr Arg Arg Ser Tyr Arg Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 LCDR1 (IMGT)

<400>  21

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  22
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 LCDR2 (IMGT)

<400>  22

Asn Ala 
1       


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 LCDR3 (IMGT) or BGA190 LCDR3 (Chothia)

<400>  23

Gln His His Phe Leu Ser Pro Trp Met 
1               5                   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR1 (Kabat)

<400>  24

Ser Phe Gly Met His 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR2 (Kabat)

<400>  25

Tyr Ile Ser Ile Gly Ser Asp Ile Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR3 (Kabat) or BGA190 HCDR3 (Chothia)  

<400>  26

Arg Ser Tyr Arg Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 LCDR1 (Kabat) or BGA190 LCDR1 (Chothia)

<400>  27

Arg Thr Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 LCDR2 (Kabat) or BGA190 LCDR2 (Chothia)

<400>  28

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR1 (Chothia)

<400>  29

Gly Phe Thr Phe Ser Ser Phe 
1               5           


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR2 (Chothia)

<400>  30

Ser Ile Gly Ser Asp Ile 
1               5       


<210>  31
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 VH

<400>  31

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Glu Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ile Gly Ser Asp Ile Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Ser Tyr Arg Ser Tyr Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 VL

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ile Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His His Phe Leu Ser Pro Trp 
                85                  90                  95      


Met Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA190 VH DNA

<400>  33
gatgtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc ccgggaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggaa tgcactgggt tcgtcaggct      120

ccagagaggg ggctggagtg ggtcgcatac attagtattg gcagtgatat catctactat      180

gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctgttc      240

ctgcaaatga ccagtctgag gtctgaggac acggccgtgt attactgtac aagaaggtct      300

tataggtcct actggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  34
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA190 VL DNA

<400>  34
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gaacaagtga gaatatttac agttatttag catggtatca gcagaaacag      120

ggaaaatctc ctcatctcct ggtctataat gcaaaaacct tagcagaggg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcatcag cctgcagcct      240

gaagattttg ggacttatta ctgtcagcat cattttctta gtccgtggat gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288  HCDR1 (IMGT)

<400>  35

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR2 (IMGT)

<400>  36

Ile Gly Pro Asn Tyr Gly Gly Thr 
1               5               


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR3 (IMGT)

<400>  37

Ala Arg Arg Gly Ser Ile Pro Arg Ala Val Asp Tyr 
1               5                   10          


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 LCDR1 (IMGT)

<400>  38

Gln Asp Ile His Asn Tyr 
1               5       


<210>  39
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 LCDR2 (IMGT)

<400>  39

Arg Ala 
1       


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 LCDR3 (IMGT) or BGA288 LCDR3 (Kabat) or BGA288 LCDR3 (Chothia)

<400>  40

Leu Gln Tyr Asp Glu Phe Pro Tyr Thr 
1               5                   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288  HCDR1 (Kabat)

<400>  41

Asp Tyr Asn Ile Asp 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR2 (Kabat)

<400>  42

Asp Ile Gly Pro Asn Tyr Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR3 (Kabat) or BGA288 HCDR3 (Chothia)

<400>  43

Arg Gly Ser Ile Pro Arg Ala Val Asp Tyr 
1               5                   10  


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 LCDR1 (Kabat) or BGA288 LCDR1 (Chothia)

<400>  44

Lys Ala Ser Gln Asp Ile His Asn Tyr Leu Ser 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 LCDR2 (Kabat) or BGA288 LCDR2 (Chothia)

<400>  45

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR1 (Chothia)

<400>  46

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR2 (Chothia)

<400>  47

Gly Pro Asn Tyr Gly Gly 
1               5       


<210>  48
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 VH

<400>  48

Glu Val Leu Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile Asp Trp Val Gln Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Gly Pro Asn Tyr Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Ala Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Ser Ile Pro Arg Ala Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 VL

<400>  49

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  50
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA288 VH DNA

<400>  50
gaggtcctgc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatt       60

ttctgtaagg cttctggata cacattcact gactacaaca tagactgggt gcagcagagc      120

catggaaaga gccttgagtg gattggagat attggtccta attatggtgg tactatctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagcca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac actgcagtct attactgtgc aagacgcggt      300

agcatcccga gggctgtgga ctactggggt caaggaacct cagtcaccgt ctcctca         357


<210>  51
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA288 VL DNA

<400>  51
gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattcat aactatttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      240

gaagatatgg gaatttatta ttgtctacag tatgatgagt ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7207 HCDR1 (IMGT)

<400>  52

Gly Phe Arg Leu Asp Thr Thr Glu 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7207 HCDR2 (IMGT)

<400>  53

Ile Met Gly Ile Ser Gly Ser Thr 
1               5               


<210>  54
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7207 HCDR3 (IMGT)

<400>  54

Ala Arg Val Val Asp Ser Leu Phe Asp Asp Ser Ala Val Phe Asp Tyr 
1               5                   10                  15      


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7207 HCDR1 (Kabat)

<400>  55

Thr Thr Glu Val Gly 
1               5   


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7207 HCDR2 (Kabat)

<400>  56

Thr Ile Met Gly Ile Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7207 HCDR3 (Kabat) or BGA-7207 HCDR3 (Chothia)

<400>  57

Val Val Asp Ser Leu Phe Asp Asp Ser Ala Val Phe Asp Tyr 
1               5                   10                  


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7207 HCDR1 (Chothia)

<400>  58

Gly Phe Arg Leu Asp Thr Thr 
1               5           


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7207 HCDR2 (Chothia)

<400>  59

Met Gly Ile Ser Gly Ser 
1               5       


<210>  60
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7207 VH

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Leu Asp Thr Thr 
            20                  25                  30          


Glu Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Met Gly Ile Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Asp Ser Leu Phe Asp Asp Ser Ala Val Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  61
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-7207 VH DNA

<400>  61
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cagattggac accaccgaag taggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccacc atcatgggta ttagtggttc gacatactat      180

gcggacagtg tcaaagggcg ctttacgatc tcgcgcgata actcaaaaaa tactctttac      240

cttcaaatga atagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

gattccctct ttgatgacag cgccgttttt gattactggg gacagggcac cttagttaca      360

gtctcatcg                                                              369


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712 HCDR1 (IMGT)

<400>  62

Gly Phe Met Leu Ser Ala Glu Asp 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712 HCDR2 (IMGT) or BGA-4712-M3 HCDR2 (IMGT)

<400>  63

Ile Leu Asp Phe Gly Gly Ser Thr 
1               5               


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712  HCDR3 (IMGT) or BGA-4712-M3 HCDR3 (IMGT)

<400>  64

Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr 
1               5                   10                  15  


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712 HCDR1 (Kabat) or BGA-4712-M3 HCDR1 (Kabat)

<400>  65

Ala Glu Asp Val Gly 
1               5   


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712 HCDR2 (Kabat)

<400>  66

Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712/BGA-4712-M3 HCDR3 (Kabat) or BGA-4712/BGA-4712-M3 HCDR3 (Chothia)

<400>  67

Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr 
1               5                   10              


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712 HCDR1 (Chothia)

<400>  68

Gly Phe Met Leu Ser Ala Glu 
1               5           


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712 HCDR2 (Chothia)

<400>  69

Leu Asp Phe Gly Gly Ser 
1               5       


<210>  70
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712 VH

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  71
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-4712 VH DNA

<400>  71
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt catgttgtcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcggacagtg tcaaagggcg ctttacgatc tcgcgcgata actcaaaaaa tactctttac      240

cttcaaatga atagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctttgat tactggggac agggcacctt agttacagtc      360

tcatcg                                                                 366


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712-M3 HCDR1 (IMGT)

<400>  72

Gly Phe Thr Leu Ser Ala Glu Asp 
1               5               


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712-M3 HCDR2 (Kabat)

<400>  73

Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712-M3 HCDR1 (Chothia)

<400>  74

Gly Phe Thr Leu Ser Ala Glu 
1               5           


<210>  75
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712-M3 VH

<400>  75

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  76
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-4712-M3 VH DNA

<400>  76
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgttgtcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctttgat tactggggac agggcacctt agttacagtc      360

tcatcg                                                                 366


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623 HCDR1 (IMGT)

<400>  77

Gly Phe Thr Val Ser Ala Glu Asp 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623 HCDR2 (IMGT)

<400>  78

Ile Leu Asp Lys Gly Gly Ser Thr 
1               5               


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623 HCDR3 (IMGT)

<400>  79

Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr 
1               5                   10                  15  


<210>  80
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623 HCDR2 (Kabat)

<400>  80

Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623 HCDR3 (Kabat/Chothia)

<400>  81

Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr 
1               5                   10              


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623 HCDR1 (Chothia)

<400>  82

Gly Phe Thr Val Ser Ala Glu 
1               5           


<210>  83
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623 HCDR2 (Chothia)

<400>  83

Leu Asp Lys Gly Gly Ser 
1               5       


<210>  84
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623 VH

<400>  84

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  85
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-5623 VH DNA

<400>  85
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggata agggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  86
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7556 VH

<400>  86

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  87
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-7556 VH DNA

<400>  87
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgttgtcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctttgat taccggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  88
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length human CEA

<400>  88

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  89
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Macaca CEA

<400>  89

Met Gly Ser Pro Ser Ala Pro Leu His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Thr Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ser Arg Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Val Ser Gln Asn Leu Phe Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Glu Arg Val Asp Ala Ser Arg Arg Ile Gly 
65                  70                  75                  80  


Ser Cys Val Ile Arg Thr Gln Gln Ile Thr Pro Gly Pro Ala His Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Asp Phe Asn Ala Ser Leu Leu Ile His Asn Val 
            100                 105                 110         


Thr Gln Ser Asp Thr Gly Ser Tyr Thr Ile Gln Val Ile Lys Glu Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Tyr Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Glu 
            180                 185                 190         


Leu Ser Ser Asp Asn Arg Thr Leu Thr Val Phe Asn Ile Pro Arg Asn 
        195                 200                 205             


Asp Thr Thr Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Val Arg 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Pro Tyr Arg Ala Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Thr Cys His Ala Ala Ser Asn Pro Thr Ala Gln Tyr Phe Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Ala Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Leu Pro Lys Pro Tyr Ile Thr Ser Asn Asn Ser Asn Pro Ile Glu 
                325                 330                 335     


Asp Lys Asp Ala Val Thr Leu Thr Cys Glu Pro Glu Thr Gln Asp Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Ser Val Ser Ser Arg 
        355                 360                 365             


Leu Glu Leu Ser Asn Asp Asn Arg Thr Leu Thr Val Phe Asn Ile Pro 
    370                 375                 380                 


Arg Asn Asp Thr Thr Phe Tyr Glu Cys Glu Thr Gln Asn Pro Val Ser 
385                 390                 395                 400 


Val Arg Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Ala Pro Thr Ile Ser Pro Leu Asn Thr Pro Tyr Arg Ala Gly Glu Asn 
            420                 425                 430         


Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Ala Ala Gln Tyr Ser 
        435                 440                 445             


Trp Phe Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Pro Asn Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His 
465                 470                 475                 480 


Asn Ser Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Ala Ile Thr Val 
                485                 490                 495     


Tyr Val Glu Leu Pro Lys Pro Tyr Ile Ser Ser Asn Asn Ser Asn Pro 
            500                 505                 510         


Ile Glu Asp Lys Asp Ala Val Thr Leu Thr Cys Glu Pro Val Ala Glu 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Ser Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Ile Leu Thr Leu Leu Ser 
545                 550                 555                 560 


Val Thr Arg Asn Asp Thr Gly Pro Tyr Glu Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Glu Ser Ala Lys Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Leu Ser Tyr Arg Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Asp Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Leu Ile Asn Gly Thr Leu Arg Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ser Lys Ile Thr Ser Asn Asn Ser Gly Ala Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Asn Ile 
            660                 665                 670         


Ser Val Ser Ser Gly Asp Ser Ala Pro Gly Ser Ser Gly Leu Ser Ala 
        675                 680                 685             


Arg Ala Thr Val Gly Ile Ile Ile Gly Met Leu Val Gly Val Ala Leu 
    690                 695                 700                 


Met 
705 


<210>  90
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length human CEACAM6

<400>  90

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly 
305                 310                 315                 320 


Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly 
                325                 330                 335     


Val Leu Ala Arg Val Ala Leu Ile 
            340                 


<210>  91
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-687 of huCEA

<400>  91

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala His 
        675                 680                 685             


His His His His His 
    690             


<210>  92
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-690 of monkey CEA

<400>  92

Met Gly Ser Pro Ser Ala Pro Leu His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Thr Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ser Arg Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Val Ser Gln Asn Leu Phe Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Glu Arg Val Asp Ala Ser Arg Arg Ile Gly 
65                  70                  75                  80  


Ser Cys Val Ile Arg Thr Gln Gln Ile Thr Pro Gly Pro Ala His Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Asp Phe Asn Ala Ser Leu Leu Ile His Asn Val 
            100                 105                 110         


Thr Gln Ser Asp Thr Gly Ser Tyr Thr Ile Gln Val Ile Lys Glu Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Tyr Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Glu 
            180                 185                 190         


Leu Ser Ser Asp Asn Arg Thr Leu Thr Val Phe Asn Ile Pro Arg Asn 
        195                 200                 205             


Asp Thr Thr Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Val Arg 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Pro Tyr Arg Ala Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Thr Cys His Ala Ala Ser Asn Pro Thr Ala Gln Tyr Phe Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Ala Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Leu Pro Lys Pro Tyr Ile Thr Ser Asn Asn Ser Asn Pro Ile Glu 
                325                 330                 335     


Asp Lys Asp Ala Val Thr Leu Thr Cys Glu Pro Glu Thr Gln Asp Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Ser Val Ser Ser Arg 
        355                 360                 365             


Leu Glu Leu Ser Asn Asp Asn Arg Thr Leu Thr Val Phe Asn Ile Pro 
    370                 375                 380                 


Arg Asn Asp Thr Thr Phe Tyr Glu Cys Glu Thr Gln Asn Pro Val Ser 
385                 390                 395                 400 


Val Arg Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Ala Pro Thr Ile Ser Pro Leu Asn Thr Pro Tyr Arg Ala Gly Glu Asn 
            420                 425                 430         


Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Ala Ala Gln Tyr Ser 
        435                 440                 445             


Trp Phe Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Pro Asn Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His 
465                 470                 475                 480 


Asn Ser Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Ala Ile Thr Val 
                485                 490                 495     


Tyr Val Glu Leu Pro Lys Pro Tyr Ile Ser Ser Asn Asn Ser Asn Pro 
            500                 505                 510         


Ile Glu Asp Lys Asp Ala Val Thr Leu Thr Cys Glu Pro Val Ala Glu 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Ser Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Ile Leu Thr Leu Leu Ser 
545                 550                 555                 560 


Val Thr Arg Asn Asp Thr Gly Pro Tyr Glu Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Glu Ser Ala Lys Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Leu Ser Tyr Arg Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Asp Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Leu Ile Asn Gly Thr Leu Arg Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ser Lys Ile Thr Ser Asn Asn Ser Gly Ala Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Asn Ile 
            660                 665                 670         


Ser Val Ser Ser Gly Asp Ser Ala Pro Gly Ser Ser Gly Leu Ser Ala 
        675                 680                 685             


Arg Ala His His His His His His 
    690                 695     


<210>  93
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-320 of CEACAM6

<400>  93

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly 
305                 310                 315                 320 


His His His His His His 
                325     


<210>  94
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-78 of huCEA

<400>  94

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn 
        115 


<210>  95
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  398-687 of huCEA

<400>  95

Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr 
1               5                   10                  15      


Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro 
            20                  25                  30          


Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala 
        35                  40                  45              


Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu 
    50                  55                  60                  


Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys 
65                  70                  75                  80  


Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr 
                85                  90                  95      


Ile Thr Val Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn 
            100                 105                 110         


Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro 
        115                 120                 125             


Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu 
    130                 135                 140                 


Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr 
145                 150                 155                 160 


Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile 
                165                 170                 175     


Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val 
            180                 185                 190         


Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr 
        195                 200                 205             


Leu Ser Gly Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro 
    210                 215                 220                 


Ser Pro Gln Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr 
225                 230                 235                 240 


Gln Val Leu Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr 
                245                 250                 255     


Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val 
            260                 265                 270         


Lys Ser Ile Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala 
        275                 280                 285             


Gly Ala 
    290 


<210>  96
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA-v

<400>  96

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn 
        115                 120                 125             


Val Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr 
    130                 135                 140                 


Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn 
145                 150                 155                 160 


Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His 
                165                 170                 175     


Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu 
            180                 185                 190         


Tyr Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr 
        195                 200                 205             


Val Lys Thr Ile Thr Val Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser 
    210                 215                 220                 


Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr 
225                 230                 235                 240 


Cys Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly 
                245                 250                 255     


Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg 
            260                 265                 270         


Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val 
        275                 280                 285             


Cys Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr 
    290                 295                 300                 


Leu Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp 
305                 310                 315                 320 


Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn Leu Ser Cys His Ser Ala 
                325                 330                 335     


Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln 
            340                 345                 350         


Gln His Thr Gln Val Leu Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn 
        355                 360                 365             


Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn 
    370                 375                 380                 


Ser Ile Val Lys Ser Ile Thr Val Ser Ala Ser Gly Thr Ser Pro Gly 
385                 390                 395                 400 


Leu Ser Ala Gly Ala His His His His His His 
                405                 410     


<210>  97
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-273 of CEACAM6

<400>  97

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser 
            


<210>  98
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  596-687 of huCEA

<400>  98

Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu 
1               5                   10                  15      


Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp 
            20                  25                  30          


Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala 
        35                  40                  45              


Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn 
    50                  55                  60                  


Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser 
65                  70                  75                  80  


Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala 
                85                  90          


<210>  99
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIM

<400>  99

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
                245                 250                 255     


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
            260                 265                 270         


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
        275                 280                 285             


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
    290                 295                 300                 


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
305                 310                 315                 320 


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala His 
                325                 330                 335     


His His His His His 
            340     


<210>  100
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM1

<400>  100

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Ser Ser Gly Pro Leu Gln 
    450                 455                 460                 


<210>  101
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM3

<400>  101

Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn 
    130                 135                 140                 


Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val 
145                 150                 155                 160 


Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu 
                165                 170                 175     


Ala Lys Thr Gly Arg Thr Ser Ile Gln Arg Asp Leu Lys Glu Gln Gln 
            180                 185                 190         


Pro Gln Ala Leu Ala Pro Gly Arg Gly Pro Ser His Ser Ser Ala Phe 
        195                 200                 205             


Ser Met Ser Pro Leu Ser Thr Ala Gln Ala Pro Leu Pro Asn Pro Arg 
    210                 215                 220                 


Thr Ala Ala Ser Ile Tyr Glu Glu Leu Leu Lys His Asp Thr Asn Ile 
225                 230                 235                 240 


Tyr Cys Arg Met Asp His Lys Ala Glu Val Ala Ser 
                245                 250         


<210>  102
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM7

<400>  102

Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn 
            20                  25                  30          


Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His 
                85                  90                  95      


Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn 
            100                 105                 110         


Val Thr His Asn Asp Ala Gly Ile Tyr Thr Leu His Val Ile Lys Glu 
        115                 120                 125             


Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu 
    130                 135                 140                 


Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn 
145                 150                 155                 160 


Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr 
                165                 170                 175     


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu 
            180                 185                 190         


Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys 
        195                 200                 205             


Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala 
    210                 215                 220                 


Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln 
225                 230                 235                 240 


Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile 
                245                 250                 255     


Gly Val Leu Ala Gly Met Ala Leu Ile 
            260                 265 


<210>  103
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM8

<400>  103

Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val 
            100                 105                 110         


Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn 
        115                 120                 125             


Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser 
    290                 295                 300                 


Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp 
305                 310                 315                 320 


Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val 
                325                 330                 335     


Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile 
            340                 345                 


<210>  104
<211>  2109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  full-length human CEA DNA

<400>  104
atggagtctc cctcggcccc tccccacaga tggtgcatcc cctggcagag gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gtgcttctac ttgtccacaa tctgccccag      180

catctttttg gctacagctg gtacaaaggt gaaagagtgg atggcaaccg tcaaattata      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagata      300

atatacccca atgcatccct gctgatccag aacatcatcc agaatgacac aggattctac      360

accctacacg tcataaagtc agatcttgtg aatgaagaag caactggcca gttccgggta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaacccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag actcaggacg caacctacct gtggtgggta      540

aacaatcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa caggaccctc      600

actctattca atgtcacaag aaatgacaca gcaagctaca aatgtgaaac ccagaaccca      660

gtgagtgcca ggcgcagtga ttcagtcatc ctgaatgtcc tctatggccc ggatgccccc      720

accatttccc ctctaaacac atcttacaga tcaggggaaa atctgaacct ctcctgccac      780

gcagcctcta acccacctgc acagtactct tggtttgtca atgggacttt ccagcaatcc      840

acccaagagc tctttatccc caacatcact gtgaataata gtggatccta tacgtgccaa      900

gcccataact cagacactgg cctcaatagg accacagtca cgacgatcac agtctatgca      960

gagccaccca aacccttcat caccagcaac aactccaacc ccgtggagga tgaggatgct     1020

gtagccttaa cctgtgaacc tgagattcag aacacaacct acctgtggtg ggtaaataat     1080

cagagcctcc cggtcagtcc caggctgcag ctgtccaatg acaacaggac cctcactcta     1140

ctcagtgtca caaggaatga tgtaggaccc tatgagtgtg gaatccagaa cgaattaagt     1200

gttgaccaca gcgacccagt catcctgaat gtcctctatg gcccagacga ccccaccatt     1260

tccccctcat acacctatta ccgtccaggg gtgaacctca gcctctcctg ccatgcagcc     1320

tctaacccac ctgcacagta ttcttggctg attgatggga acatccagca acacacacaa     1380

gagctcttta tctccaacat cactgagaag aacagcggac tctatacctg ccaggccaat     1440

aactcagcca gtggccacag caggactaca gtcaagacaa tcacagtctc tgcggagctg     1500

cccaagccct ccatctccag caacaactcc aaacccgtgg aggacaagga tgctgtggcc     1560

ttcacctgtg aacctgaggc tcagaacaca acctacctgt ggtgggtaaa tggtcagagc     1620

ctcccagtca gtcccaggct gcagctgtcc aatggcaaca ggaccctcac tctattcaat     1680

gtcacaagaa atgacgcaag agcctatgta tgtggaatcc agaactcagt gagtgcaaac     1740

cgcagtgacc cagtcaccct ggatgtcctc tatgggccgg acacccccat catttccccc     1800

ccagactcgt cttacctttc gggagcgaac ctcaacctct cctgccactc ggcctctaac     1860

ccatccccgc agtattcttg gcgtatcaat gggataccgc agcaacacac acaagttctc     1920

tttatcgcca aaatcacgcc aaataataac gggacctatg cctgttttgt ctctaacttg     1980

gctactggcc gcaataattc catagtcaag agcatcacag tctctgcatc tggaacttct     2040

cctggtctct cagctggggc cactgtcggc atcatgattg gagtgctggt tggggttgct     2100

ctgatatag                                                             2109


<210>  105
<211>  2118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  monkey CEA DNA

<400>  105
atggggtctc cctcagcccc tcttcacaga tggtgcatcc cctggcagac gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg cccagctcac tattgaatcc      120

aggccgttca atgttgcaga ggggaaggag gttcttctac ttgcccacaa tgtgtcccag      180

aatctttttg gctacatttg gtacaaggga gaaagagtgg atgccagccg tcgaattgga      240

tcatgtgtaa taagaactca acaaattacc ccagggcccg cacacagcgg tcgagagaca      300

atagacttca atgcatccct gctgatccac aatgtcaccc agagtgacac aggatcctac      360

accatacaag tcataaagga agatcttgtg aatgaagaag caactggcca gttccgggta      420

tacccggagc tgcccaagcc ctacatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttaacctg tgaacctgag actcaggaca caacctacct gtggtgggta      540

aacaatcaga gcctcccggt cagtcccagg ctggagctgt ccagtgacaa caggaccctc      600

actgtattca atattccaag aaatgacaca acatcctaca aatgtgaaac ccagaaccca      660

gtgagtgtca gacgcagcga cccagtcacc ctgaacgtcc tctatggccc ggatgcgccc      720

accatttccc ctctaaacac accttacaga gcaggggaaa atctgaacct cacctgccac      780

gcagcctcta acccaactgc acagtacttt tggtttgtca atgggacgtt ccagcaatcc      840

acacaagagc tctttatacc caacatcacc gtgaataata gcggatccta tatgtgccaa      900

gcccataact cagccactgg cctcaatagg accacagtca cggcgatcac agtctacgcg      960

gagctgccca agccctacat caccagcaac aactccaacc ccatagagga caaggatgct     1020

gtgaccttaa cctgtgaacc tgagactcag gacacaacct acctgtggtg ggtaaacaat     1080

cagagcctct cggtcagttc caggctggag ctgtccaatg acaacaggac cctcactgta     1140

ttcaatattc caagaaacga cacaacgttc tacgaatgtg agacccagaa cccagtgagt     1200

gtcagacgca gcgacccagt caccctgaat gtcctctatg gcccggatgc gcccaccatt     1260

tcccctctaa acacacctta cagagcaggg gaaaatctga acctctcctg ccacgcagcc     1320

tctaacccag ctgcacagta ctcttggttt gtcaatggga cgttccagca atccacacaa     1380

gagctcttta tacccaacat caccgtgaat aatagcggat cctatatgtg ccaagcccat     1440

aactcagcca ctggcctcaa taggaccaca gtcacggcga tcacagtcta tgtggagctg     1500

cccaagccct acatctccag caacaactcc aaccccatag aggacaagga tgctgtgacc     1560

ttaacctgtg aacctgtggc tgagaacaca acctacctgt ggtgggtaaa caatcagagc     1620

ctctcggtca gtcccaggct gcagctctcc aatggcaaca ggatcctcac tctactcagt     1680

gtcacacgga atgacacagg accctatgaa tgtggaatcc agaactcaga gagtgcaaaa     1740

cgcagtgacc cagtcaccct gaatgtcacc tatggcccag acacccccat catatccccc     1800

ccagacttgt cttaccgttc gggagcaaac ctcaacctct cctgccactc ggactctaac     1860

ccatccccgc agtattcttg gcttatcaat gggacactgc ggcaacacac acaagttctc     1920

tttatctcca aaatcacatc aaacaatagc ggggcctatg cctgttttgt ctctaacttg     1980

gctaccggtc gcaataactc catagtcaag aacatctcag tctcctctgg cgattcagca     2040

cctggaagtt ctggtctctc agctagggct actgtcggca tcataattgg aatgctggtt     2100

ggggttgctc tgatgtag                                                   2118


<210>  106
<211>  1035
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  full-length human CEACAM6 DNA

<400>  106
atgggacccc cctcagcccc tccctgcaga ttgcatgtcc cctggaagga ggtcctgctc       60

acagcctcac ttctaacctt ctggaaccca cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gttcttctac tcgcccacaa cctgccccag      180

aatcgtattg gttacagctg gtacaaaggc gaaagagtgg atggcaacag tctaattgta      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagaca      300

atatacccca atgcatccct gctgatccag aacgtcaccc agaatgacac aggattctat      360

accctacaag tcataaagtc agatcttgtg aatgaagaag caaccggaca gttccatgta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag gttcagaaca caacctacct gtggtgggta      540

aatggtcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa catgaccctc      600

actctactca gcgtcaaaag gaacgatgca ggatcctatg aatgtgaaat acagaaccca      660

gcgagtgcca accgcagtga cccagtcacc ctgaatgtcc tctatggccc agatgtcccc      720

accatttccc cctcaaaggc caattaccgt ccaggggaaa atctgaacct ctcctgccac      780

gcagcctcta acccacctgc acagtactct tggtttatca atgggacgtt ccagcaatcc      840

acacaagagc tctttatccc caacatcact gtgaataata gcggatccta tatgtgccaa      900

gcccataact cagccactgg cctcaatagg accacagtca cgatgatcac agtctctgga      960

agtgctcctg tcctctcagc tgtggccacc gtcggcatca cgattggagt gctggccagg     1020

gtggctctga tatag                                                      1035


<210>  107
<211>  2079
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-687 of huCEA DNA

<400>  107
atggagtctc cctcggcccc tccccacaga tggtgcatcc cctggcagag gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gtgcttctac ttgtccacaa tctgccccag      180

catctttttg gctacagctg gtacaaaggt gaaagagtgg atggcaaccg tcaaattata      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagata      300

atatacccca atgcatccct gctgatccag aacatcatcc agaatgacac aggattctac      360

accctacacg tcataaagtc agatcttgtg aatgaagaag caactggcca gttccgggta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaacccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag actcaggacg caacctacct gtggtgggta      540

aacaatcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa caggaccctc      600

actctattca atgtcacaag aaatgacaca gcaagctaca aatgtgaaac ccagaaccca      660

gtgagtgcca ggcgcagtga ttcagtcatc ctgaatgtcc tctatggccc ggatgccccc      720

accatttccc ctctaaacac atcttacaga tcaggggaaa atctgaacct ctcctgccac      780

gcagcctcta acccacctgc acagtactct tggtttgtca atgggacttt ccagcaatcc      840

acccaagagc tctttatccc caacatcact gtgaataata gtggatccta tacgtgccaa      900

gcccataact cagacactgg cctcaatagg accacagtca cgacgatcac agtctatgca      960

gagccaccca aacccttcat caccagcaac aactccaacc ccgtggagga tgaggatgct     1020

gtagccttaa cctgtgaacc tgagattcag aacacaacct acctgtggtg ggtaaataat     1080

cagagcctcc cggtcagtcc caggctgcag ctgtccaatg acaacaggac cctcactcta     1140

ctcagtgtca caaggaatga tgtaggaccc tatgagtgtg gaatccagaa cgaattaagt     1200

gttgaccaca gcgacccagt catcctgaat gtcctctatg gcccagacga ccccaccatt     1260

tccccctcat acacctatta ccgtccaggg gtgaacctca gcctctcctg ccatgcagcc     1320

tctaacccac ctgcacagta ttcttggctg attgatggga acatccagca acacacacaa     1380

gagctcttta tctccaacat cactgagaag aacagcggac tctatacctg ccaggccaat     1440

aactcagcca gtggccacag caggactaca gtcaagacaa tcacagtctc tgcggagctg     1500

cccaagccct ccatctccag caacaactcc aaacccgtgg aggacaagga tgctgtggcc     1560

ttcacctgtg aacctgaggc tcagaacaca acctacctgt ggtgggtaaa tggtcagagc     1620

ctcccagtca gtcccaggct gcagctgtcc aatggcaaca ggaccctcac tctattcaat     1680

gtcacaagaa atgacgcaag agcctatgta tgtggaatcc agaactcagt gagtgcaaac     1740

cgcagtgacc cagtcaccct ggatgtcctc tatgggccgg acacccccat catttccccc     1800

ccagactcgt cttacctttc gggagcgaac ctcaacctct cctgccactc ggcctctaac     1860

ccatccccgc agtattcttg gcgtatcaat gggataccgc agcaacacac acaagttctc     1920

tttatcgcca aaatcacgcc aaataataac gggacctatg cctgttttgt ctctaacttg     1980

gctactggcc gcaataattc catagtcaag agcatcacag tctctgcatc tggaacttct     2040

cctggtctct cagctggggc ccatcaccat caccatcac                            2079


<210>  108
<211>  2088
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-690 of monkey CEA DNA

<400>  108
atggggtctc cctcagcccc tcttcacaga tggtgcatcc cctggcagac gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg cccagctcac tattgaatcc      120

aggccgttca atgttgcaga ggggaaggag gttcttctac ttgcccacaa tgtgtcccag      180

aatctttttg gctacatttg gtacaaggga gaaagagtgg atgccagccg tcgaattgga      240

tcatgtgtaa taagaactca acaaattacc ccagggcccg cacacagcgg tcgagagaca      300

atagacttca atgcatccct gctgatccac aatgtcaccc agagtgacac aggatcctac      360

accatacaag tcataaagga agatcttgtg aatgaagaag caactggcca gttccgggta      420

tacccggagc tgcccaagcc ctacatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttaacctg tgaacctgag actcaggaca caacctacct gtggtgggta      540

aacaatcaga gcctcccggt cagtcccagg ctggagctgt ccagtgacaa caggaccctc      600

actgtattca atattccaag aaatgacaca acatcctaca aatgtgaaac ccagaaccca      660

gtgagtgtca gacgcagcga cccagtcacc ctgaacgtcc tctatggccc ggatgcgccc      720

accatttccc ctctaaacac accttacaga gcaggggaaa atctgaacct cacctgccac      780

gcagcctcta acccaactgc acagtacttt tggtttgtca atgggacgtt ccagcaatcc      840

acacaagagc tctttatacc caacatcacc gtgaataata gcggatccta tatgtgccaa      900

gcccataact cagccactgg cctcaatagg accacagtca cggcgatcac agtctacgcg      960

gagctgccca agccctacat caccagcaac aactccaacc ccatagagga caaggatgct     1020

gtgaccttaa cctgtgaacc tgagactcag gacacaacct acctgtggtg ggtaaacaat     1080

cagagcctct cggtcagttc caggctggag ctgtccaatg acaacaggac cctcactgta     1140

ttcaatattc caagaaacga cacaacgttc tacgaatgtg agacccagaa cccagtgagt     1200

gtcagacgca gcgacccagt caccctgaat gtcctctatg gcccggatgc gcccaccatt     1260

tcccctctaa acacacctta cagagcaggg gaaaatctga acctctcctg ccacgcagcc     1320

tctaacccag ctgcacagta ctcttggttt gtcaatggga cgttccagca atccacacaa     1380

gagctcttta tacccaacat caccgtgaat aatagcggat cctatatgtg ccaagcccat     1440

aactcagcca ctggcctcaa taggaccaca gtcacggcga tcacagtcta tgtggagctg     1500

cccaagccct acatctccag caacaactcc aaccccatag aggacaagga tgctgtgacc     1560

ttaacctgtg aacctgtggc tgagaacaca acctacctgt ggtgggtaaa caatcagagc     1620

ctctcggtca gtcccaggct gcagctctcc aatggcaaca ggatcctcac tctactcagt     1680

gtcacacgga atgacacagg accctatgaa tgtggaatcc agaactcaga gagtgcaaaa     1740

cgcagtgacc cagtcaccct gaatgtcacc tatggcccag acacccccat catatccccc     1800

ccagacttgt cttaccgttc gggagcaaac ctcaacctct cctgccactc ggactctaac     1860

ccatccccgc agtattcttg gcttatcaat gggacactgc ggcaacacac acaagttctc     1920

tttatctcca aaatcacatc aaacaatagc ggggcctatg cctgttttgt ctctaacttg     1980

gctaccggtc gcaataactc catagtcaag aacatctcag tctcctctgg cgattcagca     2040

cctggaagtt ctggtctctc agctagggct catcaccatc accatcac                  2088


<210>  109
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-320 of CEACAM6 DNA

<400>  109
atgggacccc cctcagcccc tccctgcaga ttgcatgtcc cctggaagga ggtcctgctc       60

acagcctcac ttctaacctt ctggaaccca cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gttcttctac tcgcccacaa cctgccccag      180

aatcgtattg gttacagctg gtacaaaggc gaaagagtgg atggcaacag tctaattgta      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagaca      300

atatacccca atgcatccct gctgatccag aacgtcaccc agaatgacac aggattctat      360

accctacaag tcataaagtc agatcttgtg aatgaagaag caaccggaca gttccatgta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag gttcagaaca caacctacct gtggtgggta      540

aatggtcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa catgaccctc      600

actctactca gcgtcaaaag gaacgatgca ggatcctatg aatgtgaaat acagaaccca      660

gcgagtgcca accgcagtga cccagtcacc ctgaatgtcc tctatggccc agatgtcccc      720

accatttccc cctcaaaggc caattaccgt ccaggggaaa atctgaacct ctcctgccac      780

gcagcctcta acccacctgc acagtactct tggtttatca atgggacgtt ccagcaatcc      840

acacaagagc tctttatccc caacatcact gtgaataata gcggatccta tatgtgccaa      900

gcccataact cagccactgg cctcaatagg accacagtca cgatgatcac agtctctgga      960

catcaccatc accatcac                                                    978


<210>  110
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-78 of huCEA DNA

<400>  110
atggagtctc cctcggcccc tccccacaga tggtgcatcc cctggcagag gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gtgcttctac ttgtccacaa tctgccccag      180

catctttttg gctacagctg gtacaaaggt gaaagagtgg atggcaaccg tcaaattata      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagata      300

atatacccca atgcatccct gctgatccag aacatcatcc agaat                      345


<210>  111
<211>  870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  398-687 of huCEA DNA

<400>  111
gaattaagtg ttgaccacag cgacccagtc atcctgaatg tcctctatgg cccagacgac       60

cccaccattt ccccctcata cacctattac cgtccagggg tgaacctcag cctctcctgc      120

catgcagcct ctaacccacc tgcacagtat tcttggctga ttgatgggaa catccagcaa      180

cacacacaag agctctttat ctccaacatc actgagaaga acagcggact ctatacctgc      240

caggccaata actcagccag tggccacagc aggactacag tcaagacaat cacagtctct      300

gcggagctgc ccaagccctc catctccagc aacaactcca aacccgtgga ggacaaggat      360

gctgtggcct tcacctgtga acctgaggct cagaacacaa cctacctgtg gtgggtaaat      420

ggtcagagcc tcccagtcag tcccaggctg cagctgtcca atggcaacag gaccctcact      480

ctattcaatg tcacaagaaa tgacgcaaga gcctatgtat gtggaatcca gaactcagtg      540

agtgcaaacc gcagtgaccc agtcaccctg gatgtcctct atgggccgga cacccccatc      600

atttcccccc cagactcgtc ttacctttcg ggagcgaacc tcaacctctc ctgccactcg      660

gcctctaacc catccccgca gtattcttgg cgtatcaatg ggataccgca gcaacacaca      720

caagttctct ttatcgccaa aatcacgcca aataataacg ggacctatgc ctgttttgtc      780

tctaacttgg ctactggccg caataattcc atagtcaaga gcatcacagt ctctgcatct      840

ggaacttctc ctggtctctc agctggggcc                                       870


<210>  112
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA-v DNA

<400>  112
atggagtctc cctcggcccc tccccacaga tggtgcatcc cctggcagag gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gtgcttctac ttgtccacaa tctgccccag      180

catctttttg gctacagctg gtacaaaggt gaaagagtgg atggcaaccg tcaaattata      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagata      300

atatacccca atgcatccct gctgatccag aacatcatcc agaatgaatt aagtgttgac      360

cacagcgacc cagtcatcct gaatgtcctc tatggcccag acgaccccac catttccccc      420

tcatacacct attaccgtcc aggggtgaac ctcagcctct cctgccatgc agcctctaac      480

ccacctgcac agtattcttg gctgattgat gggaacatcc agcaacacac acaagagctc      540

tttatctcca acatcactga gaagaacagc ggactctata cctgccaggc caataactca      600

gccagtggcc acagcaggac tacagtcaag acaatcacag tctctgcgga gctgcccaag      660

ccctccatct ccagcaacaa ctccaaaccc gtggaggaca aggatgctgt ggccttcacc      720

tgtgaacctg aggctcagaa cacaacctac ctgtggtggg taaatggtca gagcctccca      780

gtcagtccca ggctgcagct gtccaatggc aacaggaccc tcactctatt caatgtcaca      840

agaaatgacg caagagccta tgtatgtgga atccagaact cagtgagtgc aaaccgcagt      900

gacccagtca ccctggatgt cctctatggg ccggacaccc ccatcatttc ccccccagac      960

tcgtcttacc tttcgggagc gaacctcaac ctctcctgcc actcggcctc taacccatcc     1020

ccgcagtatt cttggcgtat caatgggata ccgcagcaac acacacaagt tctctttatc     1080

gccaaaatca cgccaaataa taacgggacc tatgcctgtt ttgtctctaa cttggctact     1140

ggccgcaata attccatagt caagagcatc acagtctctg catctggaac ttctcctggt     1200

ctctcagctg gggcccatca ccatcaccat cac                                  1233


<210>  113
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-273 of NCA DNA

<400>  113
atgggacccc cctcagcccc tccctgcaga ttgcatgtcc cctggaagga ggtcctgctc       60

acagcctcac ttctaacctt ctggaaccca cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gttcttctac tcgcccacaa cctgccccag      180

aatcgtattg gttacagctg gtacaaaggc gaaagagtgg atggcaacag tctaattgta      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagaca      300

atatacccca atgcatccct gctgatccag aacgtcaccc agaatgacac aggattctat      360

accctacaag tcataaagtc agatcttgtg aatgaagaag caaccggaca gttccatgta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag gttcagaaca caacctacct gtggtgggta      540

aatggtcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa catgaccctc      600

actctactca gcgtcaaaag gaacgatgca ggatcctatg aatgtgaaat acagaaccca      660

gcgagtgcca accgcagtga cccagtcacc ctgaatgtcc tctatggccc agatgtcccc      720

accatttcc                                                              729


<210>  114
<211>  276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  596-687 of huCEA DNA

<400>  114
cccatcattt cccccccaga ctcgtcttac ctttcgggag cgaacctcaa cctctcctgc       60

cactcggcct ctaacccatc cccgcagtat tcttggcgta tcaatgggat accgcagcaa      120

cacacacaag ttctctttat cgccaaaatc acgccaaata ataacgggac ctatgcctgt      180

tttgtctcta acttggctac tggccgcaat aattccatag tcaagagcat cacagtctct      240

gcatctggaa cttctcctgg tctctcagct ggggcc                                276


<210>  115
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIM DNA

<400>  115
atgggacccc cctcagcccc tccctgcaga ttgcatgtcc cctggaagga ggtcctgctc       60

acagcctcac ttctaacctt ctggaaccca cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gttcttctac tcgcccacaa cctgccccag      180

aatcgtattg gttacagctg gtacaaaggc gaaagagtgg atggcaacag tctaattgta      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagaca      300

atatacccca atgcatccct gctgatccag aacgtcaccc agaatgacac aggattctat      360

accctacaag tcataaagtc agatcttgtg aatgaagaag caaccggaca gttccatgta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag gttcagaaca caacctacct gtggtgggta      540

aatggtcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa catgaccctc      600

actctactca gcgtcaaaag gaacgatgca ggatcctatg aatgtgaaat acagaaccca      660

gcgagtgcca accgcagtga cccagtcacc ctgaatgtcc tctatggccc agatgtcccc      720

accatttccc ccatcatttc ccccccagac tcgtcttacc tttcgggagc gaacctcaac      780

ctctcctgcc actcggcctc taacccatcc ccgcagtatt cttggcgtat caatgggata      840

ccgcagcaac acacacaagt tctctttatc gccaaaatca cgccaaataa taacgggacc      900

tatgcctgtt ttgtctctaa cttggctact ggccgcaata attccatagt caagagcatc      960

acagtctctg catctggaac ttctcctggt ctctcagctg gggcccatca ccatcaccat     1020

cac                                                                   1023


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 HCDR1 (IMGT)

<400>  116

Gly Tyr Ile Phe Thr Ser Tyr Trp 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 HCDR2 (IMGT)

<400>  117

Ile Asn Pro Asn Thr Gly Tyr Thr 
1               5               


<210>  118
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 LCDR1 (IMGT)

<400>  118

Glu Asn Ile Tyr Gly Tyr 
1               5       


<210>  119
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 LCDR2 (IMGT)

<400>  119

Asn Ala 
1       


<210>  120
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 LCDR3 (IMGT)

<400>  120

Gln His His Tyr Gly Thr Pro Tyr Thr 
1               5                   


<210>  121
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 VH

<400>  121

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Thr Asn Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 VL

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Asn Ala Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  123
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1wt

<400>  123

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL

<400>  124

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  125
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA131 heavy chain

<400>  125

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Thr Asn Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  126
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA131 light chain

<400>  126

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  127
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA131 VH

<400>  127

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Thr Asn Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  128
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA131 VL

<400>  128

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  129
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13-1 VL

<400>  129

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  130
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13-1F VH

<400>  130

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Tyr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  131
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13-1F-ph-L VL

<400>  131

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Gln Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Phe Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Leu Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  132
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13-1F-ph-M VL

<400>  132

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Gln Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Leu Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  133
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113 VH

<400>  133

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Tyr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  134
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA113 VH DNA

<400>  134
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcta taccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360


<210>  135
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD137 FL AA

<400>  135

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  136
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD137 FL DNA

<400>  136
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctcaa ctttgagagg       60

acaagatcat tgcaggatcc ttgtagtaac tgcccagctg gtacattctg tgataataac      120

aggaatcaga tttgcagtcc ctgtcctcca aatagtttct ccagcgcagg tggacaaagg      180

acctgtgaca tatgcaggca gtgtaaaggt gttttcagga ccaggaagga gtgttcctcc      240

accagcaatg cagagtgtga ctgcactcca gggtttcact gcctgggggc aggatgcagc      300

atgtgtgaac aggattgtaa acaaggtcaa gaactgacaa aaaaaggttg taaagactgt      360

tgctttggga catttaacga tcagaaacgt ggcatctgtc gaccctggac aaactgttct      420

ttggatggaa agtctgtgct tgtgaatggg acgaaggaga gggacgtggt ctgtggacca      480

tctccagccg acctctctcc gggagcatcc tctgtgaccc cgcctgcccc tgcgagagag      540

ccaggacact ctccgcagat catctccttc tttcttgcgc tgacgtcgac tgcgttgctc      600

ttcctgctgt tcttcctcac gctccgtttc tctgttgtta aacggggcag aaagaaactc      660

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc      720

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactg                      765


<210>  137
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD137 AA 24-183

<400>  137

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


<210>  138
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD137 24-183 DNA

<400>  138
ctgcaggatc cttgtagtaa ctgcccagct ggtacattct gtgataataa caggaatcag       60

atttgcagtc cctgtcctcc aaatagtttc tccagcgcag gtggacaaag gacctgtgac      120

atatgcaggc agtgtaaagg tgttttcagg accaggaagg agtgttcctc caccagcaat      180

gcagagtgtg actgcactcc agggtttcac tgcctggggg caggatgcag catgtgtgaa      240

caggattgta aacaaggtca agaactgaca aaaaaaggtt gtaaagactg ttgctttggg      300

acatttaacg atcagaaacg tggcatctgt cgaccctgga caaactgttc tttggatgga      360

aagtctgtgc ttgtgaatgg gacgaaggag agggacgtgg tctgtggacc atctccagcc      420

gacctctctc cgggagcatc ctctgtgacc ccgcctgccc ctgcgagaga gccaggacac      480


<210>  139
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD137 -his

<400>  139

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


His His His His His His Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                165                 170                 175     


Gln Lys Ile Glu Trp His Glu 
            180             


<210>  140
<211>  549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD137 -his DNA

<400>  140
ctgcaggatc cttgtagtaa ctgcccagct ggtacattct gtgataataa caggaatcag       60

atttgcagtc cctgtcctcc aaatagtttc tccagcgcag gtggacaaag gacctgtgac      120

atatgcaggc agtgtaaagg tgttttcagg accaggaagg agtgttcctc caccagcaat      180

gcagagtgtg actgcactcc agggtttcac tgcctggggg caggatgcag catgtgtgaa      240

caggattgta aacaaggtca agaactgaca aaaaaaggtt gtaaagactg ttgctttggg      300

acatttaacg atcagaaacg tggcatctgt cgaccctgga caaactgttc tttggatgga      360

aagtctgtgc ttgtgaatgg gacgaaggag agggacgtgg tctgtggacc atctccagcc      420

gacctctctc cgggagcatc ctctgtgacc ccgcctgccc ctgcgagaga gccaggacac      480

catcaccatc accatcacgg aggcggtctg aacgacatct tcgaggctca gaaaatcgaa      540

tggcacgaa                                                              549


<210>  141
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD137 ECD-mIgG2a AA

<400>  141

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
                165                 170                 175     


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            180                 185                 190         


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        195                 200                 205             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    210                 215                 220                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
225                 230                 235                 240 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                245                 250                 255     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            260                 265                 270         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        275                 280                 285             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    290                 295                 300                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
305                 310                 315                 320 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                325                 330                 335     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            340                 345                 350         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        355                 360                 365             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    370                 375                 380                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
385                 390             


<210>  142
<211>  1179
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD137 ECD-mIgG2a DNA

<400>  142
ctgcaggatc cttgtagtaa ctgcccagct ggtacattct gtgataataa caggaatcag       60

atttgcagtc cctgtcctcc aaatagtttc tccagcgcag gtggacaaag gacctgtgac      120

atatgcaggc agtgtaaagg tgttttcagg accaggaagg agtgttcctc caccagcaat      180

gcagagtgtg actgcactcc agggtttcac tgcctggggg caggatgcag catgtgtgaa      240

caggattgta aacaaggtca agaactgaca aaaaaaggtt gtaaagactg ttgctttggg      300

acatttaacg atcagaaacg tggcatctgt cgaccctgga caaactgttc tttggatgga      360

aagtctgtgc ttgtgaatgg gacgaaggag agggacgtgg tctgtggacc atctccagcc      420

gacctctctc cgggagcatc ctctgtgacc ccgcctgccc ctgcgagaga gccaggacac      480

gagcccagag ggcccacaat caagccctgt cctccatgca aatgcccagc acctaacctc      540

ttgggtggac catccgtctt catcttccct ccaaagatca aggatgtact catgatctcc      600

ctgagcccca tagtcacatg tgtggtggtg gatgtgagcg aggatgaccc agatgtccag      660

atcagctggt ttgtgaacaa cgtggaagta cacacagctc agacacaaac ccatagagag      720

gattacaaca gtactctccg ggtggtcagt gccctcccca tccagcacca ggactggatg      780

agtggcaagg agttcaaatg caaggtcaac aacaaagacc tcccagcgcc catcgagaga      840

accatctcaa aacccaaagg gtcagtaaga gctccacagg tatatgtctt gcctccacca      900

gaagaagaga tgactaagaa acaggtcact ctgacctgca tggtcacaga cttcatgcct      960

gaagacattt acgtggagtg gaccaacaac gggaaaacag agctaaacta caagaacact     1020

gaaccagtcc tggactctga tggttcttac ttcatgtaca gcaagctgag agtggaaaag     1080

aagaactggg tggaaagaaa tagctactcc tgttcagtgg tccacgaggg tctgcacaat     1140

caccacacga ctaagagctt ctcccggact ccgggtaaa                            1179


<210>  143
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mIgG2a AA

<400>  143

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             


<210>  144
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgG2a DNA

<400>  144
gagcccagag ggcccacaat caagccctgt cctccatgca aatgcccagc acctaacctc       60

ttgggtggac catccgtctt catcttccct ccaaagatca aggatgtact catgatctcc      120

ctgagcccca tagtcacatg tgtggtggtg gatgtgagcg aggatgaccc agatgtccag      180

atcagctggt ttgtgaacaa cgtggaagta cacacagctc agacacaaac ccatagagag      240

gattacaaca gtactctccg ggtggtcagt gccctcccca tccagcacca ggactggatg      300

agtggcaagg agttcaaatg caaggtcaac aacaaagacc tcccagcgcc catcgagaga      360

accatctcaa aacccaaagg gtcagtaaga gctccacagg tatatgtctt gcctccacca      420

gaagaagaga tgactaagaa acaggtcact ctgacctgca tggtcacaga cttcatgcct      480

gaagacattt acgtggagtg gaccaacaac gggaaaacag agctaaacta caagaacact      540

gaaccagtcc tggactctga tggttcttac ttcatgtaca gcaagctgag agtggaaaag      600

aagaactggg tggaaagaaa tagctactcc tgttcagtgg tccacgaggg tctgcacaat      660

caccacacga ctaagagctt ctcccggact ccgggtaaa                             699


<210>  145
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD137 ligand AA

<400>  145

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  146
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD137 ligand cDNA

<400>  146
atggaatacg cctctgacgc ttcactggac cccgaagccc cgtggcctcc cgcgccccgc       60

gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg ggctgctgct gctgctgctg      120

ctcgctgccg cctgcgccgt cttcctcgcc tgcccctggg ccgtgtccgg ggctcgcgcc      180

tcgcccggct ccgcggccag cccgagactc cgcgagggtc ccgagctttc gcccgacgat      240

cccgccggcc tcttggacct gcggcagggc atgtttgcgc agctggtggc ccaaaatgtt      300

ctgctgatcg atgggcccct gagctggtac agtgacccag gcctggcagg cgtgtccctg      360

acggggggcc tgagctacaa agaggacacg aaggagctgg tggtggccaa ggctggagtc      420

tactatgtct tctttcaact agagctgcgg cgcgtggtgg ccggcgaggg ctcaggctcc      480

gtttcacttg cgctgcacct gcagccactg cgctctgctg ctggggccgc cgccctggct      540

ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga actcggcctt cggtttccag      600

ggccgcttgc tgcacctgag tgccggccag cgcctgggcg tccatcttca cactgaggcc      660

agggcacgcc atgcctggca gcttacccag ggcgccacag tcttgggact cttccgggtg      720

acccccgaaa tcccagccgg actcccttca ccgaggtcgg aataa                      765


<210>  147
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD137 ligand 71-254 AA

<400>  147

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 


<210>  148
<211>  552
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD137 ligand 71-254 DNA

<400>  148
cgcgagggtc ccgagctttc gcccgacgat cccgccggcc tcttggacct gcggcagggc       60

atgtttgcgc agctggtggc ccaaaatgtt ctgctgatcg atgggcccct gagctggtac      120

agtgacccag gcctggcagg cgtgtccctg acggggggcc tgagctacaa agaggacacg      180

aaggagctgg tggtggccaa ggctggagtc tactatgtct tctttcaact agagctgcgg      240

cgcgtggtgg ccggcgaggg ctcaggctcc gtttcacttg cgctgcacct gcagccactg      300

cgctctgctg ctggggccgc cgccctggct ttgaccgtgg acctgccacc cgcctcctcc      360

gaggctcgga actcggcctt cggtttccag ggccgcttgc tgcacctgag tgccggccag      420

cgcctgggcg tccatcttca cactgaggcc agggcacgcc atgcctggca gcttacccag      480

ggcgccacag tcttgggact cttccgggtg acccccgaaa tcccagccgg actcccttca      540

ccgaggtcgg aa                                                          552


<210>  149
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD137 ligand-mIgG2a AA

<400>  149

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly Gly Gly Gly Ser Arg Glu 
225                 230                 235                 240 


Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
                245                 250                 255     


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
            260                 265                 270         


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
        275                 280                 285             


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
    290                 295                 300                 


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
305                 310                 315                 320 


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
                325                 330                 335     


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
            340                 345                 350         


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
        355                 360                 365             


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
    370                 375                 380                 


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
385                 390                 395                 400 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                405                 410                 415     


Pro Ser Pro Arg Ser Glu 
            420         


<210>  150
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD137 ligand-mIgG2a DNA

<400>  150
gagcccagag ggcccacaat caagccctgt cctccatgca aatgcccagc acctaacctc       60

ttgggtggac catccgtctt catcttccct ccaaagatca aggatgtact catgatctcc      120

ctgagcccca tagtcacatg tgtggtggtg gatgtgagcg aggatgaccc agatgtccag      180

atcagctggt ttgtgaacaa cgtggaagta cacacagctc agacacaaac ccatagagag      240

gattacaaca gtactctccg ggtggtcagt gccctcccca tccagcacca ggactggatg      300

agtggcaagg agttcaaatg caaggtcaac aacaaagacc tcccagcgcc catcgagaga      360

accatctcaa aacccaaagg gtcagtaaga gctccacagg tatatgtctt gcctccacca      420

gaagaagaga tgactaagaa acaggtcact ctgacctgca tggtcacaga cttcatgcct      480

gaagacattt acgtggagtg gaccaacaac gggaaaacag agctaaacta caagaacact      540

gaaccagtcc tggactctga tggttcttac ttcatgtaca gcaagctgag agtggaaaag      600

aagaactggg tggaaagaaa tagctactcc tgttcagtgg tccacgaggg tctgcacaat      660

caccacacga ctaagagctt ctcccggact ccgggtaaag gtggaggcgg ttcacgcgag      720

ggtcccgagc tttcgcccga cgatcccgcc ggcctcttgg acctgcggca gggcatgttt      780

gcgcagctgg tggcccaaaa tgttctgctg atcgatgggc ccctgagctg gtacagtgac      840

ccaggcctgg caggcgtgtc cctgacgggg ggcctgagct acaaagagga cacgaaggag      900

ctggtggtgg ccaaggctgg agtctactat gtcttctttc aactagagct gcggcgcgtg      960

gtggccggcg agggctcagg ctccgtttca cttgcgctgc acctgcagcc actgcgctct     1020

gctgctgggg ccgccgccct ggctttgacc gtggacctgc cacccgcctc ctccgaggct     1080

cggaactcgg ccttcggttt ccagggccgc ttgctgcacc tgagtgccgg ccagcgcctg     1140

ggcgtccatc ttcacactga ggccagggca cgccatgcct ggcagcttac ccagggcgcc     1200

acagtcttgg gactcttccg ggtgaccccc gaaatcccag ccggactccc ttcaccgagg     1260

tcggaa                                                                1266


<210>  151
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyno CD137 FL AA

<400>  151

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Leu Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Ser Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Lys Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Ile Ser Gly Tyr His Cys Leu Gly 
                85                  90                  95      


Ala Glu Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Ala Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Phe Phe Leu Ala 
            180                 185                 190         


Leu Thr Ser Thr Val Val Leu Phe Leu Leu Phe Phe Leu Val Leu Arg 
        195                 200                 205             


Phe Ser Val Val Lys Arg Ser Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 


<210>  152
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cyno CD137 FL DNA

<400>  152
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctgaa ctttgagagg       60

acaagatcct tgcaggatct gtgtagtaac tgcccagctg gtacattctg tgataataac      120

aggagtcaga tttgcagtcc ctgtcctcca aatagtttct ccagcgcagg tggacaaagg      180

acctgtgaca tatgcaggca gtgtaaaggt gttttcaaga ccaggaagga gtgttcctcc      240

accagcaatg cagagtgtga ctgcatttca ggatatcact gcctgggggc agaatgcagc      300

atgtgtgaac aggattgtaa acaaggtcaa gaattgacaa aaaaaggttg taaagactgt      360

tgctttggga catttaatga ccagaaacgt ggcatctgtc gaccctggac aaactgttct      420

ttggatggaa agtctgtgct tgtgaatggg acgaaggaga gggacgtggt ctgcggacca      480

tctccagccg acctctctcc aggagcatcc tctgcgaccc cgcctgcccc tgcgagagag      540

ccaggacact ctccgcagat catcttcttt cttgcgctga cttcgactgt ggtactcttc      600

ctgctgttct tcctcgtgct ccgtttctct gttgttaaac ggagcagaaa gaaactcctg      660

tatatattca aacaaccatt tatgagaccg gtacaaacca ctcaagagga agatggatgt      720

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgtga                      765


<210>  153
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyno CD137 ECD 24-186 AA

<400>  153

Leu Gln Asp Leu Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Ser Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Lys Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Ile Ser Gly Tyr His Cys Leu Gly Ala Glu Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Ala Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln 
            


<210>  154
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cyno CD137 ECD 24-186 DNA

<400>  154
ctgcaggatc tgtgtagtaa ctgcccagct ggtacattct gtgataataa caggagtcag       60

atttgcagtc cctgtcctcc aaatagtttc tccagcgcag gtggacaaag gacctgtgac      120

atatgcaggc agtgtaaagg tgttttcaag accaggaagg agtgttcctc caccagcaat      180

gcagagtgtg actgcatttc aggatatcac tgcctggggg cagaatgcag catgtgtgaa      240

caggattgta aacaaggtca agaattgaca aaaaaaggtt gtaaagactg ttgctttggg      300

acatttaatg accagaaacg tggcatctgt cgaccctgga caaactgttc tttggatgga      360

aagtctgtgc ttgtgaatgg gacgaaggag agggacgtgg tctgcggacc atctccagcc      420

gacctctctc caggagcatc ctctgcgacc ccgcctgccc ctgcgagaga gccaggacac      480

tctccgcag                                                              489


<210>  155
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyno CD137 ECD-mIgG2a AA

<400>  155

Leu Gln Asp Leu Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Ser Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Lys Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Ile Ser Gly Tyr His Cys Leu Gly Ala Glu Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Ala Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys 
                165                 170                 175     


Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe 
            180                 185                 190         


Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val 
        195                 200                 205             


Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile 
    210                 215                 220                 


Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr 
225                 230                 235                 240 


His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro 
                245                 250                 255     


Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val 
            260                 265                 270         


Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro 
        275                 280                 285             


Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu 
    290                 295                 300                 


Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp 
305                 310                 315                 320 


Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr 
                325                 330                 335     


Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser 
            340                 345                 350         


Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu 
        355                 360                 365             


Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His 
    370                 375                 380                 


His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
385                 390                 395     


<210>  156
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cyno CD137 ECD-mIgG2a DNA

<400>  156
ctgcaggatc tgtgtagtaa ctgcccagct ggtacattct gtgataataa caggagtcag       60

atttgcagtc cctgtcctcc aaatagtttc tccagcgcag gtggacaaag gacctgtgac      120

atatgcaggc agtgtaaagg tgttttcaag accaggaagg agtgttcctc caccagcaat      180

gcagagtgtg actgcatttc aggatatcac tgcctggggg cagaatgcag catgtgtgaa      240

caggattgta aacaaggtca agaattgaca aaaaaaggtt gtaaagactg ttgctttggg      300

acatttaatg accagaaacg tggcatctgt cgaccctgga caaactgttc tttggatgga      360

aagtctgtgc ttgtgaatgg gacgaaggag agggacgtgg tctgcggacc atctccagcc      420

gacctctctc caggagcatc ctctgcgacc ccgcctgccc ctgcgagaga gccaggacac      480

tctccgcagg agcccagagg gcccacaatc aagccctgtc ctccatgcaa atgcccagca      540

cctaacctct tgggtggacc atccgtcttc atcttccctc caaagatcaa ggatgtactc      600

atgatctccc tgagccccat agtcacatgt gtggtggtgg atgtgagcga ggatgaccca      660

gatgtccaga tcagctggtt tgtgaacaac gtggaagtac acacagctca gacacaaacc      720

catagagagg attacaacag tactctccgg gtggtcagtg ccctccccat ccagcaccag      780

gactggatga gtggcaagga gttcaaatgc aaggtcaaca acaaagacct cccagcgccc      840

atcgagagaa ccatctcaaa acccaaaggg tcagtaagag ctccacaggt atatgtcttg      900

cctccaccag aagaagagat gactaagaaa caggtcactc tgacctgcat ggtcacagac      960

ttcatgcctg aagacattta cgtggagtgg accaacaacg ggaaaacaga gctaaactac     1020

aagaacactg aaccagtcct ggactctgat ggttcttact tcatgtacag caagctgaga     1080

gtggaaaaga agaactgggt ggaaagaaat agctactcct gttcagtggt ccacgagggt     1140

ctgcacaatc accacacgac taagagcttc tcccggactc cgggtaaa                  1188


<210>  157
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD40 AA

<400>  157

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  158
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD40 DNA

<400>  158
atggttcgtc tgcctctgca gtgcgtcctc tggggctgct tgctgaccgc tgtccatcca       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

aaatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccccaggat cggctgagag ccctggtggt gatccccatc      600

atcttcggga tcctgtttgc catcctcttg gtgctggtct ttatcaaaaa ggtggccaag      660

aagccaacca ataaggcccc ccaccccaag caggaacccc aggagatcaa ttttcccgac      720

gatcttcctg gctccaacac tgctgctcca gtgcaggaga ctttacatgg atgccaaccg      780

gtcacccagg aggatggcaa agagagtcgc atctcagtgc aggagagaca gtga            834


<210>  159
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huCD40 ECD AA (1-194)

<400>  159

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala 
        


<210>  160
<211>  582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huCD40 ECD DNA (1-194)

<400>  160
atggttcgtc tgcctctgca gtgcgtcctc tggggctgct tgctgaccgc tgtccatcca       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgaatt cctagacacc tggaacagag agacacactg ccaccagcac      240

aaatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccccaggat cggctgagag cc                         582


<210>  161
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD40 ECD-mIgG2a AA

<400>  161

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys 
        195                 200                 205             


Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe 
    210                 215                 220                 


Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile 
                245                 250                 255     


Ser Trp Phe Val Asn Asn Val Glu Val Leu Thr Ala Gln Thr Gln Thr 
            260                 265                 270         


His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro 
        275                 280                 285             


Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val 
    290                 295                 300                 


Asn Asn Lys Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro 
305                 310                 315                 320 


Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu 
                325                 330                 335     


Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp 
            340                 345                 350         


Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr 
        355                 360                 365             


Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser 
    370                 375                 380                 


Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu 
385                 390                 395                 400 


Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His 
                405                 410                 415     


His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            420                 425             


<210>  162
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD40 ECD-mIgG2a DNA

<400>  162
atggttcgtc tgcctctgca gtgcgtcctc tggggctgct tgctgaccgc tgtccatcca       60

gaaccaccca ctgcatgcag agaaaaacag tacctaataa acagtcagtg ctgttctttg      120

tgccagccag gacagaaact ggtgagtgac tgcacagagt tcactgaaac ggaatgcctt      180

ccttgcggtg aaagcgagtt cctagacacc tggaacagag agacacactg ccaccagcac      240

aaatactgcg accccaacct agggcttcgg gtccagcaga agggcacctc agaaacagac      300

accatctgca cctgtgaaga aggctggcac tgtacgagtg aggcctgtga gagctgtgtc      360

ctgcaccgct catgctcgcc cggctttggg gtcaagcaga ttgctacagg ggtttctgat      420

accatctgcg agccctgccc agtcggcttc ttctccaatg tgtcatctgc tttcgaaaaa      480

tgtcaccctt ggacaagctg tgagaccaaa gacctggttg tgcaacaggc aggcacaaac      540

aagactgatg ttgtctgtgg tccccaggat cggctgagag ctagcgagcc cagagggccc      600

acaatcaagc cctgtcctcc atgcaaatgc ccagcaccta acctcttggg tggaccatcc      660

gtcttcatct tccctccaaa gatcaaggat gtactcatga tctccctgag ccccatggtc      720

acatgtgtgg tggtggatgt gagcgaggat gacccagatg tccagatcag ctggttcgtg      780

aacaacgtgg aagtactcac agctcagaca caaacccata gagaggatta caacagtact      840

ctccgggtgg tcagtgccct ccccatccag caccaggact ggatgagtgg caaggagttc      900

aaatgcaagg tcaacaacaa agccctccca gcgcccatcg agagaaccat ctcaaaaccc      960

aaagggtcag taagagctcc acaggtatat gtcttgcctc caccagaaga agagatgact     1020

aagaaacagg tcactctgac ctgcatggtc acagacttca tgcctgaaga catttacgtg     1080

gagtggacca acaacgggaa aacagagcta aactacaaga acactgaacc agtcctggac     1140

tctgatggtt cttacttcat gtacagcaag ctgagagtgg aaaagaagaa ctgggtggaa     1200

agaaatagct actcctgctc agtggtccac gagggtctgc acaatcacca cacgactaag     1260

agcttctccc ggactccggg taaa                                            1284


<210>  163
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human OX40 AA

<400>  163

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  164
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human OX40 DNA

<400>  164
atgtgcgtgg gggctcggcg gctgggccgc gggccgtgtg cggctctgct cctcctgggc       60

ctggggctga gcaccgtgac ggggctccac tgtgtcgggg acacctaccc cagcaacgac      120

cggtgctgcc acgagtgcag gccaggcaac gggatggtga gccgctgcag ccgctcccag      180

aacacggtgt gccgtccgtg cgggccgggc ttctacaacg acgtggtcag ctccaagccg      240

tgcaagccct gcacgtggtg taacctcaga agtgggagtg agcggaagca gctgtgcacg      300

gccacacagg acacagtctg ccgctgccgg gcgggcaccc agcccctgga cagctacaag      360

cctggagttg actgtgcccc ctgccctcca gggcacttct ccccaggcga caaccaggcc      420

tgcaagccct ggaccaactg caccttggct gggaagcaca ccctgcagcc ggccagcaat      480

agctcggacg caatctgtga ggacagggac cccccagcca cgcagcccca ggagacccag      540

ggccccccgg ccaggcccat cactgtccag cccactgaag cctggcccag aacctcacag      600

ggaccctcca cccggcccgt ggaggtcccc gggggccgtg cggttgccgc catcctgggc      660

ctgggcctgg tgctggggct gctgggcccc ctggccatcc tgctggccct gtacctgctc      720

cggagggacc agaggctgcc ccccgatgcc cacaagcccc ctgggggagg cagtttccgg      780

acccccatcc aagaggagca ggccgacgcc cactccaccc tggccaagat ctga            834


<210>  165
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human OX40 ECD (1-216) AA

<400>  165

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala 
    210                 215     


<210>  166
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human OX40 ECD (1-216) DNA

<400>  166
atgtgcgtgg gggctcggcg gctgggccgc gggccgtgtg cggctctgct cctcctgggc       60

ctggggctga gcaccgtgac ggggctccac tgtgtcgggg acacctaccc cagcaacgac      120

cggtgctgcc acgagtgcag gccaggcaac gggatggtga gccgctgcag ccgctcccag      180

aacacggtgt gccgtccgtg cgggccgggc ttctacaacg acgtggtcag ctccaagccg      240

tgcaagccct gcacgtggtg taacctcaga agtgggagtg agcggaagca gctgtgcacg      300

gccacacagg acacagtctg ccgctgccgg gcgggcaccc agcccctgga cagctacaag      360

cctggagttg actgtgcccc ctgccctcca gggcacttct ccccaggcga caaccaggcc      420

tgcaagccct ggaccaactg caccttggct gggaagcaca ccctgcagcc ggccagcaat      480

agctcggacg caatctgtga ggacagggac cccccagcca cgcagcccca ggagacccag      540

ggccccccgg ccaggcccat cactgtccag cccactgaag cctggcccag aacctcacag      600

ggaccctcca cccggcccgt ggaggtcccc gggggccgtg cggttgcc                   648


<210>  167
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human OX40 ECD-His AA

<400>  167

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala His His His His His His 
    210                 215                 220         


<210>  168
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human OX40 ECD-His DNA

<400>  168
atgtgcgtgg gggctcggcg gctgggccgc gggccgtgtg cggctctgct cctcctgggc       60

ctggggctga gcaccgtgac ggggctccac tgtgtcgggg acacctaccc cagcaacgac      120

cggtgctgcc acgagtgcag gccaggcaac gggatggtga gccgctgcag ccgctcccag      180

aacacggtgt gccgtccgtg cgggccgggc ttctacaacg acgtggtcag ctccaagccg      240

tgcaagccct gcacgtggtg taacctcaga agtgggagtg agcggaagca gctgtgcacg      300

gccacacagg acacagtctg ccgctgccgg gcgggcaccc agcccctgga cagctacaag      360

cctggagttg actgtgcccc ctgccctcca gggcacttct ccccaggcga caaccaggcc      420

tgcaagccct ggaccaactg caccttggct gggaagcaca ccctgcagcc ggccagcaat      480

agctcggacg caatctgtga ggacagggac cccccagcca cgcagcccca ggagacccag      540

ggccccccgg ccaggcccat cactgtccag cccactgaag cctggcccag aacctcacag      600

ggaccctcca cccggcccgt ggaggtcccc gggggccgtg cggttgccca tcaccatcac      660

catcac                                                                 666


<210>  169
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-23 germline AA

<400>  169

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  170
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-23 germline DNA

<400>  170
gaagtgcagc tgctggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatgcga ttagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgagcgcg attagcggca gcggcggtag cacctattat      180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgccgtgt attattgcgc gcgt            294


<210>  171
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7207 VH-Fc

<400>  171

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Leu Asp Thr Thr 
            20                  25                  30          


Glu Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Met Gly Ile Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Asp Ser Leu Phe Asp Asp Ser Ala Val Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  172
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-7207 VH-Fc DNA

<400>  172
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cagattggac accaccgaag taggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccacc atcatgggta ttagtggttc gacatactat      180

gcggacagtg tcaaagggcg ctttacgatc tcgcgcgata actcaaaaaa tactctttac      240

cttcaaatga atagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

gattccctct ttgatgacag cgccgttttt gattactggg gacagggcac cttagttaca      360

gtctcatcgg gcggcggagg gtctgacaag acccacacat gccccccttg tcctgctcca      420

ccagctgcag gaccaagcgt gttcctgttt ccacccaagc ccaaggatac cctgatgatc      480

tctcggaccc cagaggtgac atgcgtggtg gtggatgtga gccacgagga ccccgaggtg      540

aagttcaact ggtatgtgga cggcgtggag gtgcacaatg ctaagaccaa gcccagggag      600

gagcagtaca actccaccta tagagtggtg tctgtgctga cagtgctgca ccaggattgg      660

ctgaacggca aggagtataa gtgcaaggtg tccaataagg ccctggccgc tcctatcgag      720

aagaccatct ctaaggccaa gggccagccc agagagcctc aggtgtacac actgcctcca      780

tcccgggaag agatgaccaa gaaccaggtg tctctgacat gtctggtcaa gggcttctat      840

ccctctgaca tcgccgtgga gtgggagagc aatggccagc ctgagaacaa ttacaagacc      900

acaccccctg tgctggattc cgacggctct ttctttctgt atagcaagct gaccgtggac      960

aagtcccggt ggcagcaggg caacgtgttc agctgttccg tgatgcacga agctctgcat     1020

aatcactata ctcagaaatc cctgtcactg tcacctggta aa                        1062


<210>  173
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712 VH-Fc

<400>  173

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  174
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-4712 VH-Fc DNA

<400>  174
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt catgttgtcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcggacagtg tcaaagggcg ctttacgatc tcgcgcgata actcaaaaaa tactctttac      240

cttcaaatga atagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctttgat tactggggac agggcacctt agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  175
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Inert Fc-A Fc-null version IgG1

<400>  175

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly 
1               5                   10                  15      


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            20                  25                  30          


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        35                  40                  45              


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    50                  55                  60                  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
65                  70                  75                  80  


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                85                  90                  95      


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu 
            100                 105                 110         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        115                 120                 125             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    130                 135                 140                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
145                 150                 155                 160 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                165                 170                 175     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            180                 185                 190         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        195                 200                 205             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    210                 215                 220                 


Gly Lys 
225     


<210>  176
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inert Fc-A Fc-null version IgG1 DNA

<400>  176
gacaagaccc acacatgccc cccttgtcct gctccaccag ctgcaggacc aagcgtgttc       60

ctgtttccac ccaagcccaa ggataccctg atgatctctc ggaccccaga ggtgacatgc      120

gtggtggtgg atgtgagcca cgaggacccc gaggtgaagt tcaactggta tgtggacggc      180

gtggaggtgc acaatgctaa gaccaagccc agggaggagc agtacaactc cacctataga      240

gtggtgtctg tgctgacagt gctgcaccag gattggctga acggcaagga gtataagtgc      300

aaggtgtcca ataaggccct ggccgctcct atcgagaaga ccatctctaa ggccaagggc      360

cagcccagag agcctcaggt gtacacactg cctccatccc gggaagagat gaccaagaac      420

caggtgtctc tgacatgtct ggtcaagggc ttctatccct ctgacatcgc cgtggagtgg      480

gagagcaatg gccagcctga gaacaattac aagaccacac cccctgtgct ggattccgac      540

ggctctttct ttctgtatag caagctgacc gtggacaagt cccggtggca gcagggcaac      600

gtgttcagct gttccgtgat gcacgaagct ctgcataatc actatactca gaaatccctg      660

tcactgtcac ctggtaaa                                                    678


<210>  177
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-CD137/CEA A-BGA-4712/CEA heavy chain AA

<400>  177

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Met Leu Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                565                 570                 575     


<210>  178
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A-CD137/CEA A-BGA-4712/CEA heavy chain DNA

<400>  178
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcatgttgt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga ttttggtggt tcgacatact atgcggacag tgtcaaaggg     1560

cgctttacga tctcgcgcga taactcaaaa aatactcttt accttcaaat gaatagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgtcg tctaccatgc tggtggtggc     1680

gtcacctttg attactgggg acagggcacc ttagttacag tctcatcg                  1728


<210>  179
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-CD137/CEA anti-CEA Ab light chain AA

<400>  179

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Gln Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Tyr Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Leu Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  180
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A-CD137/CEA anti-CEA Ab light chain DNA

<400>  180
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc gcgcgagcga aaaccagtat ggctatctgg cgtggtatca gcagaaaccg      120

ggcaaagtgc cgaaactgct gatttataac tataaaaacc tggtggaagg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagatgtgg cgacctatta ttgccagcat catctgggca ccccgtatac ctttggccag      300

ggcaccaaag tggaaattaa acgaacagtg gcagcccctt ccgtcttcat ttttccccct      360

tctgacgaac agctgaaatc aggaactgct agcgtggtct gtctgctgaa caatttctac      420

cccagagagg ccaaggtgca gtggaaagtc gataacgctc tgcagtccgg caattctcag      480

gagagtgtga ccgaacagga ctcaaaggat agcacatatt ccctgtctag tactctgacc      540

ctgagcaaag cagactacga gaagcacaaa gtgtatgcct gtgaagtcac acaccagggg      600

ctgagttcac cagtcaccaa gagtttcaac agaggggaat gc                         642


<210>  181
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-CD137/CEA anti-CEA Ab heavy chain AA

<400>  181

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  182
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-CD137/CEA anti-CEA Ab heavy chain DNA

<400>  182
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaa                                         1347


<210>  183
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-CD137/CEA B-BGA-4712/CEA light chain AA

<400>  183

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Gln Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Tyr Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Leu Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
    210                 215                 220                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
225                 230                 235                 240 


Cys Ala Ala Ser Gly Phe Met Leu Ser Ala Glu Asp Val Gly Trp Val 
                245                 250                 255     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp 
            260                 265                 270         


Phe Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        275                 280                 285             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    290                 295                 300                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr 
305                 310                 315                 320 


His Ala Gly Gly Gly Val Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
                325                 330                 335     


Val Thr Val Ser Ser 
            340     


<210>  184
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-CD137/CEA B-BGA-4712/CEA light chain DNA

<400>  184
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc gcgcgagcga aaaccagtat ggctatctgg cgtggtatca gcagaaaccg      120

ggcaaagtgc cgaaactgct gatttataac tataaaaacc tggtggaagg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagatgtgg cgacctatta ttgccagcat catctgggca ccccgtatac ctttggccag      300

ggcaccaaag tggaaattaa acgaacagtg gcagcccctt ccgtcttcat ttttccccct      360

tctgacgaac agctgaaatc aggaactgct agcgtggtct gtctgctgaa caatttctac      420

cccagagagg ccaaggtgca gtggaaagtc gataacgctc tgcagtccgg caattctcag      480

gagagtgtga ccgaacagga ctcaaaggat agcacatatt ccctgtctag tactctgacc      540

ctgagcaaag cagactacga gaagcacaaa gtgtatgcct gtgaagtcac acaccagggg      600

ctgagttcac cagtcaccaa gagtttcaac agaggggaat gcgggggagg cgggtccgag      660

gtccagttac ttgagagtgg tggaggtctg gtccaaccag gaggttcgct gcgtttatcc      720

tgcgccgcgt ctggattcat gttgtccgcc gaagacgtgg gttgggtgcg tcaagcgccg      780

gggaaaggac tggaatgggt ctccgccatc ttggattttg gtggttcgac atactatgcg      840

gacagtgtca aagggcgctt tacgatctcg cgcgataact caaaaaatac tctttacctt      900

caaatgaata gccttcgtgc tgaggacact gcggtgtact actgcgcccg cgtcgtctac      960

catgctggtg gtggcgtcac ctttgattac tggggacagg gcaccttagt tacagtctca     1020

tcg                                                                   1023


<210>  185
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-CD137/CEA C-BGA-4712/CEA heavy chain AA

<400>  185

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
225                 230                 235                 240 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                245                 250                 255     


Met Leu Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys 
            260                 265                 270         


Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr 
        275                 280                 285             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    290                 295                 300                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
305                 310                 315                 320 


Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ala Gly Gly Gly Val 
                325                 330                 335     


Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
        355                 360                 365             


Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe Leu Phe 
    370                 375                 380                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
385                 390                 395                 400 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                405                 410                 415     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            420                 425                 430         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        435                 440                 445             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    450                 455                 460                 


Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
465                 470                 475                 480 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                485                 490                 495     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            500                 505                 510         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        515                 520                 525             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    530                 535                 540                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
545                 550                 555                 560 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                565                 570                 575     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585             


<210>  186
<211>  1764
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-CD137/CEA C-BGA-4712/CEA heavy chain DNA

<400>  186
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acgggggagg cgggtccgag gtccagttac ttgagagtgg tggaggtctg      720

gtccaaccag gaggttcgct gcgtttatcc tgcgccgcgt ctggattcat gttgtccgcc      780

gaagacgtgg gttgggtgcg tcaagcgccg gggaaaggac tggaatgggt ctccgccatc      840

ttggattttg gtggttcgac atactatgcg gacagtgtca aagggcgctt tacgatctcg      900

cgcgataact caaaaaatac tctttacctt caaatgaata gccttcgtgc tgaggacact      960

gcggtgtact actgcgcccg cgtcgtctac catgctggtg gtggcgtcac ctttgattac     1020

tggggacagg gcaccttagt tacagtctca tcgtctggtg gaggcggttc agagcccaaa     1080

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctcctgctgc cggaccgtca     1140

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     1200

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1260

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1320

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1380

aagtgcaagg tctccaacaa agccctcgca gcccccatcg agaaaaccat ctccaaagcc     1440

aaagggcagc cccgagaacc acaggtctac accctgcccc catcccggga ggagatgacc     1500

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1560

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1620

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1680

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1740

agcctctccc tgtctccggg taaa                                            1764


<210>  187
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D-CD137/CEA D-BGA-4712/CEA heavy chain AA

<400>  187

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Met Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
145                 150                 155                 160 


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
                165                 170                 175     


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
            180                 185                 190         


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
        195                 200                 205             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
                245                 250                 255     


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
            260                 265                 270         


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
        275                 280                 285             


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
    290                 295                 300                 


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
305                 310                 315                 320 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
                325                 330                 335     


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
            340                 345                 350         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


Lys 
    


<210>  188
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D-CD137/CEA D-BGA-4712/CEA heavy chain DNA

<400>  188
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt catgttgtcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcggacagtg tcaaagggcg ctttacgatc tcgcgcgata actcaaaaaa tactctttac      240

cttcaaatga atagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctttgat tactggggac agggcacctt agttacagtc      360

tcatcgtccg gtggaggcgg ttcacaggtg cagctggtgc agagcggcgc ggaagtgaaa      420

aaaccgggcg cgagcgtgaa agtgagctgc aaagcgagcg gctatatttt taccagctat      480

tacctgcatt gggtgcgcca ggcgccgggc cagggcctgg aatggattgg ctatattaac      540

ccgcagaccg gcaagaccag ctatgcccag aaatttcagg gccgcgtgac catgacccgc      600

gataccagca ccagcaccgt gtatatggaa ctgagcagcc tgcgcagcga agataccgcg      660

gtgtattatt gcgcgcgcga atatggcaac tataactatc cgctggatta ttggggccag      720

ggcaccctgg tgaccgtgag cagcgctagc accaaggggc cctcggtctt ccccctggca      780

ccctcctcca agagtacttc tgggggcaca gcggccctgg gctgcctggt caaggactac      840

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      900

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      960

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc     1020

aaggtggaca agaaagttga gccaaagtcc tgtgacaaga cccacacatg ccccccttgt     1080

cctgctccac cagctgcagg accaagcgtg ttcctgtttc cacccaagcc caaggatacc     1140

ctgatgatct ctcggacccc agaggtgaca tgcgtggtgg tggatgtgag ccacgaggac     1200

cccgaggtga agttcaactg gtatgtggac ggcgtggagg tgcacaatgc taagaccaag     1260

cccagggagg agcagtacaa ctccacctat agagtggtgt ctgtgctgac agtgctgcac     1320

caggattggc tgaacggcaa ggagtataag tgcaaggtgt ccaataaggc cctggccgct     1380

cctatcgaga agaccatctc taaggccaag ggccagccca gagagcctca ggtgtacaca     1440

ctgcctccat cccgggaaga gatgaccaag aaccaggtgt ctctgacatg tctggtcaag     1500

ggcttctatc cctctgacat cgccgtggag tgggagagca atggccagcc tgagaacaat     1560

tacaagacca caccccctgt gctggattcc gacggctctt tctttctgta tagcaagctg     1620

accgtggaca agtcccggtg gcagcagggc aacgtgttca gctgttccgt gatgcacgaa     1680

gctctgcata atcactatac tcagaaatcc ctgtcactgt cacctggtaa a              1731


<210>  189
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4712-M3-mutFc AA

<400>  189

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  190
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-4712-M3-mutFc DNA

<400>  190
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgttgtcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctttgat tactggggac agggcacctt agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  191
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-CEAxCD137-M3 AA

<400>  191

Gly Ser Ala Thr Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Trp Phe Pro Gly Ser Arg Ser Gln Val Gln Leu Val Gln 
            20                  25                  30          


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
        35                  40                  45              


Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr Tyr Leu His Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Gln 
65                  70                  75                  80  


Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met 
                85                  90                  95      


Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu 
            100                 105                 110         


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Gly Asn 
        115                 120                 125             


Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                485                 490                 495     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            500                 505                 510         


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        515                 520                 525             


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    530                 535                 540                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
545                 550                 555                 560 


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                565                 570                 575     


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr Trp 
            580                 585                 590         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        595                 600         


<210>  192
<211>  1821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A-CEAxCD137-M3 DNA

<400>  192
ggatccgcca ccatggatat gagagttcct gctcaattgc tggggttgct cttgctctgg       60

tttcctggct cgagaagcca ggtgcagctg gtgcagagcg gcgcggaagt gaaaaaaccg      120

ggcgcgagcg tgaaagtgag ctgcaaagcg agcggctata tttttaccag ctattacctg      180

cattgggtgc gccaggcgcc gggccagggc ctggaatgga ttggctatat taacccgcag      240

accggcaaga ccagctatgc ccagaaattt cagggccgcg tgaccatgac ccgcgatacc      300

agcaccagca ccgtgtatat ggaactgagc agcctgcgca gcgaagatac cgcggtgtat      360

tattgcgcgc gcgaatatgg caactataac tatccgctgg attattgggg ccagggcacc      420

ctggtgaccg tgagcagcgc tagcaccaag gggccctcgg tcttccccct ggcaccctcc      480

tccaagagta cttctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      540

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      660

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      720

gacaagaaag ttgagccaaa gtcctgtgac aagacccaca catgcccccc ttgtcctgct      780

ccaccagctg caggaccaag cgtgttcctg tttccaccca agcccaagga taccctgatg      840

atctctcgga ccccagaggt gacatgcgtg gtggtggatg tgagccacga ggaccccgag      900

gtgaagttca actggtatgt ggacggcgtg gaggtgcaca atgctaagac caagcccagg      960

gaggagcagt acaactccac ctatagagtg gtgtctgtgc tgacagtgct gcaccaggat     1020

tggctgaacg gcaaggagta taagtgcaag gtgtccaata aggccctggc cgctcctatc     1080

gagaagacca tctctaaggc caagggccag cccagagagc ctcaggtgta cacactgcct     1140

ccatcccggg aagagatgac caagaaccag gtgtctctga catgtctggt caagggcttc     1200

tatccctctg acatcgccgt ggagtgggag agcaatggcc agcctgagaa caattacaag     1260

accacacccc ctgtgctgga ttccgacggc tctttctttc tgtatagcaa gctgaccgtg     1320

gacaagtccc ggtggcagca gggcaacgtg ttcagctgtt ccgtgatgca cgaagctctg     1380

cataatcact atactcagaa atccctgtca ctgtcacctg gtaaaggtgg aggcggttca     1440

gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta     1500

tcctgcgccg cgtctggatt cacgttgtcc gccgaagacg tgggttgggt gcgtcaagcg     1560

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat     1620

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac     1680

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc     1740

taccatgctg gtggtggcgt cacctttgat tactggggac agggcacctt agttacagtc     1800

tcatcgtgaa agcttcgtca g                                               1821


<210>  193
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7556-mutFc AA

<400>  193

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  194
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-7556-mutFc DNA

<400>  194
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgttgtcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctttgat taccggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  195
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A- BGA-7556 AA

<400>  195

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Leu Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  196
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A- BGA-7556 DNA

<400>  196
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacgttgt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga ttttggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgtcg tctaccatgc tggtggtggc     1680

gtcacctttg attaccgggg acagggcacc caagttacag tctcatcg                  1728


<210>  197
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3 AA

<400>  197

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  198
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH3 DNA

<400>  198
ggccagccca gagagcctca ggtgtacaca ctgcctccat cccgggaaga gatgaccaag       60

aaccaggtgt ctctgacatg tctggtcaag ggcttctatc cctctgacat cgccgtggag      120

tgggagagca atggccagcc tgagaacaat tacaagacca caccccctgt gctggattcc      180

gacggctctt tctttctgta tagcaagctg accgtggaca agtcccggtg gcagcagggc      240

aacgtgttca gctgttccgt gatgcacgaa gctctgcata atcactatac tcagaaatcc      300

ctgtcactgt cacctggtaa a                                                321


<210>  199
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3- BGA-4712-M3 AA

<400>  199

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        115                 120                 125             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
    130                 135                 140                 


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
145                 150                 155                 160 


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
                165                 170                 175     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
            180                 185                 190         


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        195                 200                 205             


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 


<210>  200
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CH3- BGA-4712-M3 DNA

<400>  200
ggccagccca gagagcctca ggtgtacaca ctgcctccat cccgggaaga gatgaccaag       60

aaccaggtgt ctctgacatg tctggtcaag ggcttctatc cctctgacat cgccgtggag      120

tgggagagca atggccagcc tgagaacaat tacaagacca caccccctgt gctggattcc      180

gacggctctt tctttctgta tagcaagctg accgtggaca agtcccggtg gcagcagggc      240

aacgtgttca gctgttccgt gatgcacgaa gctctgcata atcactatac tcagaaatcc      300

ctgtcactgt cacctggtaa aggtggaggc ggttcagagg tccagttact tgagagtggt      360

ggaggtctgg tccaaccagg aggttcgctg cgtttatcct gcgccgcgtc tggattcacg      420

ttgtccgccg aagacgtggg ttgggtgcgt caagcgccgg ggaaaggact ggaatgggtc      480

tccgccatct tggattttgg tggttcgaca tactatgcgg aaagtgtcaa agggcgcttt      540

acgatctcgc gcgataacgc aaaaaatact ctttaccttc aaatgtctag ccttcgtgct      600

gaggacactg cggtgtacta ctgcgcccgc gtcgtctacc atgctggtgg tggcgtcacc      660

tttgattact ggggacaggg caccttagtt acagtctcat cg                         702


<210>  201
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-2690 AA

<400>  201

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Arg Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Ser Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  202
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-2690 DNA

<400>  202
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgctttcc agagaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt tcggttcttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccatgctg gtggtggcgt cacctatgat tatcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  203
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-3849 AA

<400>  203

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser His Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  204
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-3849 DNA

<400>  204
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgctttcc catgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ccggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgctatgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  205
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7916 AA

<400>  205

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  206
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-7916 DNA

<400>  206
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt cgggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccatgctg gtggtggcgt cacctatgat actcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  207
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4988 AA

<400>  207

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Arg Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  208
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-4988 DNA

<400>  208
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatc ggggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccatgctg gtggtggcgt cacctatgat actcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  209
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5164 AA

<400>  209

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp His Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  210
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-5164 DNA

<400>  210
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgctttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatc atggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccatgctg gtggtggcgt cacctatgat tatcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  211
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-3953 AA

<400>  211

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  212
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-3953 DNA

<400>  212
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt cgggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  213
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5385 AA

<400>  213

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp His Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ile Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  214
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-5385 DNA

<400>  214
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgctttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatc atggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttatc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  215
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-9468 AA

<400>  215

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ser Gly Gly Gly Val Thr Phe Asp Leu Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  216
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-9468 DNA

<400>  216
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt cgggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccattctg gtggtggcgt cacctttgat cttcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  217
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-3285 AA

<400>  217

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  218
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-3285 DNA

<400>  218
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgatttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  219
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-9442 AA

<400>  219

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Leu Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  220
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-9442 DNA

<400>  220
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgatttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ctggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgctatgtc      300

taccatgctg gtggtggcgt cacctttgat cttcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  221
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7746 AA

<400>  221

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  222
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-7746 DNA

<400>  222
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcagaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctttgat acgcggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  223
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-8425 AA

<400>  223

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  224
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-8425 DNA

<400>  224
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgctgtcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt cgggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctatgat taccggggac agggcaccca agttacagtc      360

tcatcg                                                                 366


<210>  225
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-3386 AA

<400>  225

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  226
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-3386 DNA

<400>  226
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggata agggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat acttggggac agggcacctt agttacagtc      360

tcatcg                                                                 366


<210>  227
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623-mutFc-AA

<400>  227

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  228
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-5623-mutFc DNA

<400>  228
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggata agggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  229
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-2690- mutFc AA

<400>  229

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Arg Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Ser Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  230
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-2690 mutFc DNA

<400>  230
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgctttcc agagaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt tcggttcttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccatgctg gtggtggcgt cacctatgat tatcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  231
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-3849-mutFc

AA

<400>  231

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser His Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  232
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-3849 mutFc DNA

<400>  232
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgctttcc catgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ccggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgctatgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  233
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7916-mutFc AA

<400>  233

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  234
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-7916-mutFc DNA

<400>  234
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt cgggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccatgctg gtggtggcgt cacctatgat actcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  235
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-4988-mutFc AA

<400>  235

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Arg Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  236
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-4988-mutFc DNA

<400>  236
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatc ggggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccatgctg gtggtggcgt cacctatgat actcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  237
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5164-mutFc AA

<400>  237

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp His Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  238
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-5164-mutFc

DNA

<400>  238
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgctttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatc atggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccatgctg gtggtggcgt cacctatgat tatcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  239
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-3953-mutFc AA

<400>  239

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  240
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-3953-mutFc DNA

<400>  240
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt cgggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  241
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5385-mutFc AA

<400>  241

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp His Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ile Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  242
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-5385-mutFc DNA

<400>  242
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgctttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatc atggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttatc      300

taccatgctg gtggtggcgt cacctatgat tatcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  243
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-9468-mutFc AA

<400>  243

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ser Gly Gly Gly Val Thr Phe Asp Leu Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  244
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-9468-mutFc DNA

<400>  244
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt cgggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccattctg gtggtggcgt cacctttgat cttcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  245
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-3285-mutFc

AA

<400>  245

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  246
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-3285-mutFc DNA

<400>  246
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgatttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgttgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  247
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-9442-mutFc AA

<400>  247

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Leu Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  248
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-9442-mutFc DNA

<400>  248
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgatttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ctggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgctatgtc      300

taccatgctg gtggtggcgt cacctttgat cttcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  249
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-7746-mutFc AA

<400>  249

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  250
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-7746-mutFc DNA

<400>  250
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt ttggtggttc gacatactat      180

gcagaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctttgat acgcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  251
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-8425-mutFc AA

<400>  251

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Tyr His Ala Gly Gly Gly Val Thr Tyr Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  252
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-8425-mutFc DNA

<400>  252
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacgctgtcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggatt cgggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcgtcgtc      300

taccatgctg gtggtggcgt cacctatgat taccggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  253
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-3386-mutFc AA

<400>  253

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys 
    


<210>  254
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-3386-mutFc

DNA

<400>  254
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggata agggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat acttggggac agggcacctt agttacagtc      360

tcatcgggcg gcggagggtc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaa                            1059


<210>  255
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-5623AA (BE-189)

<400>  255

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Ile Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  256
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-5623 DNA

<400>  256
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacggttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga taagggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcattg tctaccatgc tggtggtggc     1680

gtcacctttg atactcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  257
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-2690

AA

<400>  257

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Leu Ser Arg Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Phe Gly Ser Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Tyr Asp Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  258
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-2690 DNA

<400>  258
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacgcttt ccagagaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga tttcggttct tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgttg tctaccatgc tggtggtggc     1680

gtcacctatg attatcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  259
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-3849

AA

<400>  259

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Leu Ser His Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  260
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-3849 DNA

<400>  260
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacgcttt cccatgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga ttccggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgctatg tctaccatgc tggtggtggc     1680

gtcacctttg atactcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  261
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-7916 AA

<400>  261

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Tyr Asp Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  262
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-7916 DNA

<400>  262
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacggttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga ttcgggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgttg tctaccatgc tggtggtggc     1680

gtcacctatg atactcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  263
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-4988 AA

<400>  263

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Arg Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Tyr Asp Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  264
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-4988 DNA

<400>  264
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacggttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga tcggggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgttg tctaccatgc tggtggtggc     1680

gtcacctatg atactcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  265
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-5164 AA

<400>  265

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Leu Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp His Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Tyr Asp Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  266
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-5164 DNA

<400>  266
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacgcttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga tcatggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgttg tctaccatgc tggtggtggc     1680

gtcacctatg attatcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  267
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-3953 AA

<400>  267

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Ile Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  268
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-3953 DNA

<400>  268
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacggttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga ttcgggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcattg tctaccatgc tggtggtggc     1680

gtcacctttg atactcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  269
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-5385 AA

<400>  269

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Leu Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp His Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Ile Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  270
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-5385 DNA

<400>  270
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacgcttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga tcatggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgtta tctaccatgc tggtggtggc     1680

gtcacctttg atactcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  271
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-9468

AA

<400>  271

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ser Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Leu Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  272
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-9468

DNA

<400>  272
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacggttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga ttcgggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgttg tctaccattc tggtggtggc     1680

gtcacctttg atcttcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  273
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-3285

AA

<400>  273

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  274
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-3285 DNA

<400>  274
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacgattt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga ttttggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgttg tctaccatgc tggtggtggc     1680

gtcacctttg atactcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  275
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-9442

AA

<400>  275

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Ile Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Leu Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  276
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-9442

DNA

<400>  276
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacgattt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga ttctggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgctatg tctaccatgc tggtggtggc     1680

gtcacctttg atcttcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  277
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-7746

AA

<400>  277

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Phe Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  278
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-7746

DNA

<400>  278
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacggttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga ttttggtggt tcgacatact atgcagaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgtcg tctaccatgc tggtggtggc     1680

gtcacctttg atacgcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  279
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-8425

AA

<400>  279

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Leu Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Ser Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Val Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Tyr Asp Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  280
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-8425 DNA

<400>  280
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacgctgt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga ttcgggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcgtcg tctaccatgc tggtggtggc     1680

gtcacctatg attaccgggg acagggcacc caagttacag tctcatcg                  1728


<210>  281
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Format A BGA-3386

AA

<400>  281

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Ile Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                565                 570                 575     


<210>  282
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Format A BGA-3386

DNA

<400>  282
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacggttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga taagggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcattg tctaccatgc tggtggtggc     1680

gtcacctttg atacttgggg acagggcacc ttagttacag tctcatcg                  1728


<210>  283
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623  IgG1 AA

<400>  283

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  284
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-5623 IgG1 DNA

<400>  284
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggata agggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa      420

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      480

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      540

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      600

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      660

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      720

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      780

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      840

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      900

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      960

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1020

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1062


<210>  285
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA-5623 IgG4 AA

<400>  285

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro 
        115                 120                 125             


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
    130                 135                 140                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
145                 150                 155                 160 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
                165                 170                 175     


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            180                 185                 190         


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Trp Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            340                 345                 350 


<210>  286
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA-5623 IgG4 DNA

<400>  286
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggata agggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcggaat ccaagtatgg tccgccatgt ccaccgtgcc cggcacccga gtttttggga      420

gggcctagtg tgtttttgtt tcctcctaag ccaaaggaca cgcttatgat tagtcgcaca      480

cccgaggtta cctgtgtagt ggtggacgta tcacaagagg atccggaagt ccaatttaat      540

tggtacgtcg acggagtgga agtccacaat gcaaagacca agcctaggga agaacagttc      600

aattctacct atcgctggtc tgtactcact gtactccacc aggattggct caatggaaag      660

gaatacaaat gcaaggtttc caacaaaggg ctcccctctt ccattgagaa aactattagc      720

aaggctaaag gccaacccag agaaccacag gtttataccc ttccaccttc ccaggaggag      780

atgacgaaga atcaggttag tcttacgtgc ctcgttaaag gattctaccc ttcagatatc      840

gcagttgaat gggagtctaa cgggcaaccc gagaacaact acaagaccac cccgccggtg      900

ctggactcag atggtagttt ctttctttac agtcggctta ccgtcgacaa gtcacgctgg      960

caggagggaa atgtattctc ctgcagcgta atgcacgaag ctctgcacaa tcactatacc     1020

cagaagtcac tgagcctttc tctgggtaag                                      1050


<210>  287
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Urelumab analog-Heavy chain AA

<400>  287

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Trp Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  288
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Urelumab analog-Heavy chain DNA

<400>  288
caagttcaac ttcagcagtg gggagcgggt ctcttgaagc ctagtgagac gctgagcctg       60

acctgtgcag tctacggggg ttcattttct gggtactact ggtcctggat acgccaaagc      120

ccagagaaag gcctggaatg gattggggag ataaatcacg ggggttatgt gacatataat      180

ccttctcttg agagccgggt cacgatatct gttgacacaa gtaaaaatca gttctccctc      240

aaactgagct ccgttaccgc agcagacact gccgtttact actgtgcgcg ggactatggg      300

ccaggtaatt acgattggta cttcgacctg tggggtagag gaacgctggt cactgtaagc      360

agtgcatcta caaagggccc cagcgtgttt ccccttgcac catgttcacg gagcactagt      420

gaaagcactg ccgcgctcgg gtgtctcgtt aaggattatt ttccggagcc tgtcactgtc      480

tcttggaact ctggtgcact gacatcaggc gttcacacgt tccctgcagt actccagagc      540

tcaggattgt acagcctgtc cagtgtagtt acagtgcctt cctcctccct tggaacaaag      600

acctacacct gcaacgtgga ccataagccc agcaatacga aagtagacaa acgagtcgaa      660

tccaagtatg gtccgccatg tccaccgtgc ccggcacccg agtttttggg agggcctagt      720

gtgtttttgt ttcctcctaa gccaaaggac acgcttatga ttagtcgcac acccgaggtt      780

acctgtgtag tggtggacgt atcacaagag gatccggaag tccaatttaa ttggtacgtc      840

gacggagtgg aagtccacaa tgcaaagacc aagcctaggg aagaacagtt caattctacc      900

tatcgctggt ctgtactcac tgtactccac caggattggc tcaatggaaa ggaatacaaa      960

tgcaaggttt ccaacaaagg gctcccctct tccattgaga aaactattag caaggctaaa     1020

ggccaaccca gagaaccaca ggtttatacc cttccacctt cccaggagga gatgacgaag     1080

aatcaggtta gtcttacgtg cctcgttaaa ggattctacc cttcagatat cgcagttgaa     1140

tgggagtcta acgggcaacc cgagaacaac tacaagacca ccccgccggt gctggactca     1200

gatggtagtt tctttcttta cagtcggctt accgtcgaca agtcacgctg gcaggaggga     1260

aatgtattct cctgcagcgt aatgcacgaa gctctgcaca atcactatac ccagaagtca     1320

ctgagccttt ctctgggtaa g                                               1341


<210>  289
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Urelumab analog-Light chain AA

<400>  289

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  290
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Urelumab analog-Light chain DNA

<400>  290
gaaatcgtgc tgacccaatc acctgcgacc ctctccctta gccctggaga acgagcaact       60

ctcagttgca gagcaagcca gagcgtcagc tcatatctcg catggtatca acaaaaacca      120

ggccaagctc ctagactgtt gatttatgat gcctctaacc gggcgactgg cataccagcc      180

cgctttagcg ggtctgggag tggcactgat tttacgctca cgatttcatc tttggagcca      240

gaagatttcg ctgtatacta ctgtcaacaa aggtcaaact ggccgcctgc acttacgttc      300

ggcgggggta ccaaggtgga gattaagagg acagttgcgg cgccatcagt ttttatattc      360

ccaccctccg atgagcagtt gaaaagtggc acggcatcag ttgtctgtct gctgaacaat      420

ttctatccac gggaggcgaa agtccaatgg aaagtggaca atgcgcttca gagcgggaac      480

tctcaggaga gtgtcactga acaggattca aaggactcca cgtactcact ctcatccact      540

ctcacccttt caaaggcgga ttacgaaaag cataaggtct acgcttgtga ggtaacacat      600

caggggcttt ccagtcctgt aaccaagagc ttcaatcgcg gcgaatgc                   648


<210>  291
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Utomilumab analog-Heavy chain AA

<400>  291

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210>  292
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Utomilumab analog-Heavy chain DNA

<400>  292
gaagttcaac tggtacagtc cggtgctgaa gttaaaaaac ccggagagag tctgagaatc       60

tcttgcaagg ggtctgggta ctcttttagt acatattgga tatcttgggt gagacaaatg      120

ccggggaaag gcctcgaatg gatgggcaag atttatcccg gagacagcta tacaaattac      180

tcacctagtt ttcaaggtca ggtaactatc agcgcggaca aatccataag tacggcctat      240

ctgcaatggt cttccttgaa ggcatccgac acggcgatgt attactgcgc aagagggtat      300

ggtatattcg attactgggg gcagggcact ctcgttaccg tgagcagcgc ttcaacaaaa      360

ggcccatctg tcttccctct cgcgccttgc tcccgctcta cttcagagtc aacagctgct      420

ctggggtgct tggtgaagga ttactttcct gaaccggtta ctgtcagctg gaattctggg      480

gctttgacga gcggagttca cactttccca gctgtactgc aaagttctgg actttacagc      540

ttgagctccg tggtgacagt gccgagctca aacttcggta cgcagacata tacatgcaat      600

gtggatcata aacccagcaa tacgaaagta gataagacag tcgaaaggaa gtgttgtgta      660

gagtgcccac cgtgccccgc ccctccggtt gcaggcccat cagtgtttct cttcccgccc      720

aaacctaagg acacgctgat gatttcacga acgcccgagg tcacctgtgt cgtagtcgat      780

gtgtcccatg aggacccaga agttcagttc aattggtatg tagacggcgt ggaggtacac      840

aatgcaaaaa cgaaaccacg cgaggaacag ttcaatagta cgttccgggt cgtgagtgtg      900

ctcacggtgg ttcaccaaga ctggctgaac gggaaagaat ataagtgcaa agtatccaat      960

aaaggcctgc ccgcacccat cgaaaaaact ataagtaaaa ctaaagggca accgcgagag     1020

cctcaggtct atactttgcc accgtcacgc gaagagatga ccaagaacca agtaagtctt     1080

acttgcttgg tcaaggggtt ctacccctca gatatagcgg tggagtggga atccaatggc     1140

caacccgaga acaattacaa gacaacacca ccaatgctgg actctgacgg gagtttcttt     1200

ctgtatagta aacttaccgt cgataaatca cgctggcagc aaggcaacgt attctcatgc     1260

tcagtaatgc atgaagcctt gcataatcac tacactcaga aaagcctgtc cctctctcca     1320

ggtaag                                                                1326


<210>  293
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Utomilumab analog-Light chain AA

<400>  293

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Lys Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Tyr Thr Gly Phe Gly Ser Leu 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  294
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Utomilumab analog-Light chain DNA

<400>  294
agctacgagt tgactcagcc accatccgtc agtgttagcc ccggacagac ggcgtcaatt       60

acttgtagtg gagacaacat tggcgatcag tacgcccatt ggtatcagca aaaaccgggt      120

caatcaccag ttctggtgat atatcaggat aagaatcgac catcagggat tccagagagg      180

ttctcaggta gtaactcagg taacacagct actctgacca taagtggtac ccaggctatg      240

gacgaagcag actactactg cgccacctac acaggcttcg gatcacttgc ggttttcggg      300

ggcggaacca aactaaccgt tcttgggcaa cctaaggctg ccccgtccgt gactcttttt      360

cctccgtctt ccgaagagct tcaagccaat aaagcaacct tggtatgttt gatttccgat      420

ttttaccctg gagcggtgac ggtggcatgg aaagctgatt caagccctgt gaaagctggg      480

gtggaaacta ctacgccgtc caaacagagc aataataagt acgcggcctc cagctatttg      540

tcacttaccc cggagcaatg gaagtcacac cgaagttaca gttgtcaagt tactcacgaa      600

ggcagcactg ttgaaaagac cgtagcaccc accgaatgct ca                         642


<210>  295
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE-718 

A-BGA-5623- BGA-5623 heavy chain AA

<400>  295

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Ile Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            580                 585                 590         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        595                 600                 605             


Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys 
    610                 615                 620                 


Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr 
625                 630                 635                 640 


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                645                 650                 655     


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            660                 665                 670         


Ala Val Tyr Tyr Cys Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val 
        675                 680                 685             


Thr Phe Asp Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    690                 695                 700             


<210>  296
<211>  2109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BE-718 

A-BGA-5623- BGA-5623 heavy chain DNA

<400>  296
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacggttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga taagggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcattg tctaccatgc tggtggtggc     1680

gtcacctttg atactcgggg acagggcacc caagttacag tctcatcggg cggcggagga     1740

tcggaggtcc agttacttga gagtggtgga ggtctggtcc aaccaggagg ttcgctgcgt     1800

ttatcctgcg ccgcgtctgg attcacggtt tccgccgaag acgtgggttg ggtgcgtcaa     1860

gcgccgggga aaggactgga atgggtctcc gccatcttgg ataagggtgg ttcgacatac     1920

tatgcggaaa gtgtcaaagg gcgctttacg atctcgcgcg ataacgcaaa aaatactctt     1980

taccttcaaa tgtctagcct tcgtgctgag gacactgcgg tgtactactg cgcccgcatt     2040

gtctaccatg ctggtggtgg cgtcaccttt gatactcggg gacagggcac ccaagttaca     2100

gtctcatcg                                                             2109


<210>  297
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE-740 AA

<400>  297

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly 
    450                 455                 460                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
465                 470                 475                 480 


Gly Phe Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro 
                485                 490                 495     


Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Lys Gly Gly Ser 
            500                 505                 510         


Thr Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        515                 520                 525             


Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
    530                 535                 540                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ile Val Tyr His Ala Gly Gly 
545                 550                 555                 560 


Gly Val Thr Phe Asp Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
                565                 570                 575     


Ser 
    


<210>  298
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BE-740 DNA

<400>  298
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa ggtggaggcg gttcagaggt ccagttactt     1380

gagagtggtg gaggtctggt ccaaccagga ggttcgctgc gtttatcctg cgccgcgtct     1440

ggattcacgg tttccgccga agacgtgggt tgggtgcgtc aagcgccggg gaaaggactg     1500

gaatgggtct ccgccatctt ggataagggt ggttcgacat actatgcgga aagtgtcaaa     1560

gggcgcttta cgatctcgcg cgataacgca aaaaatactc tttaccttca aatgtctagc     1620

cttcgtgctg aggacactgc ggtgtactac tgcgcccgca ttgtctacca tgctggtggt     1680

ggcgtcacct ttgatactcg gggacagggc acccaagtta cagtctcatc g              1731


<210>  299
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE-942

(ZW1+1) anti-CEA heavy chain AA

<400>  299

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Trp 
    130                 135                 140                 


Leu Gly Cys Glu Val Thr Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Glu Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ser Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  300
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BE-942 

(ZW1+1) anti-CEA heavy chain DNA

<400>  300
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca agggaccaag cgtgttccca ctggcaccca gctccaagag cacctccgga      420

ggaacagcat ggctgggatg cgaggtgacc gactacttcc ccgagcctgt gacagtgtct      480

tggaacagcg gcgccctgac cagcggagtg cacacatttc ctgccgtgct ggagtctagc      540

ggcctgtact ccctgtcctc tgtggtgacc gtgcctagct cctctctggg cacccagaca      600

tatatctgta acgtgaatca caagccatct aatacaaagg tggataagaa ggtggagcca      660

aagtcctgcg acaagaccca cacatgccca ccttgtccag caccagaggc agcaggagga      720

ccatccgtgt tcctgtttcc acccaagccc aaggataccc tgatgatctc tcggaccccc      780

gaggtgacat gcgtggtggt gagcgtgtcc cacgaggacc ctgaggtgaa gttcaactgg      840

tacgtggatg gcgtggaggt gcacaatgcc aagacaaagc cccgggagga gcagtacaac      900

agcacctata gagtggtgtc cgtgctgaca gtgctgcacc aggactggct gaacggcaag      960

gagtataagt gcaaggtgtc taataaggcc ctgcctgccc caatcgagaa gaccatcagc     1020

aaggcaaagg gacagcccag ggagcctcag gtgtacgtgc tgcctccaag ccgcgacgag     1080

ctgacaaaga accaggtgtc cctgctgtgc ctggtgaagg gcttctatcc ttccgatatc     1140

gccgtggagt gggagtctaa tggccagcca gagaacaatt acctgacctg gccccctgtg     1200

ctggactccg atggctcttt ctttctgtat tctaagctga cagtggataa gagcaggtgg     1260

cagcagggca acgtgttttc ttgcagcgtg atgcacgagg ccctgcacaa tcactacacc     1320

cagaagtccc tgtctctgag ccctggcaag                                      1350


<210>  301
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE-942

(ZW1+1) anti-CEA light chain AA

<400>  301

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Gln Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Tyr Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Leu Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Ala Ile Phe Pro Pro Ser Asp Glu Arg Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Val Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Arg Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  302
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BE-942

(ZW1+1) anti-CEA light chain DNA

<400>  302
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc gcgcgagcga aaaccagtat ggctatctgg cgtggtatca gcagaaaccg      120

ggcaaagtgc cgaaactgct gatttataac tataaaaacc tggtggaagg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagatgtgg cgacctatta ttgccagcat catctgggca ccccgtatac ctttggccag      300

ggcaccaaag tggaaattaa aaggacagtg gcagcaccaa gcgtggcaat cttcccacct      360

tccgacgaga gactgaagtc cggcaccgct agcgtggtgt gcgtgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gataacgccc tgcagtccgg caattctcag      480

gagagcgtga ccgagcagga ctccaaggat tctacatata gcctgagctc caggctgacc      540

ctgtctaagg ccgactacga gaagcacaag gtgtatgcct gcgaggtgac acaccagggc      600

ctgtctagcc ccgtgaccaa gtccttcaac cgcggcgagt gt                         642


<210>  303
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE-942

(ZW1+1) anti-CD137 heavy chain AA

<400>  303

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ser Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  304
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BE-942

(ZW1+1) anti-CD137 heavy chain DNA

<400>  304
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggata agggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcggagc caaagtcctc cgacaagacc cacacatgcc caccttgtcc agcaccagag      420

gcagcaggag gaccatccgt gttcctgttt ccacccaagc ccaaggatac cctgatgatc      480

tctcggaccc ccgaggtgac atgcgtggtg gtgagcgtgt cccacgagga ccctgaggtg      540

aagttcaact ggtacgtgga tggcgtggag gtgcacaatg ccaagacaaa gccccgggag      600

gagcagtaca acagcaccta tagagtggtg tccgtgctga cagtgctgca ccaggactgg      660

ctgaacggca aggagtataa gtgcaaggtg tctaataagg ccctgcctgc cccaatcgag      720

aagaccatca gcaaggcaaa gggacagccc agggagcctc aggtgtacgt gtatcctcca      780

agccgcgacg agctgaccaa gaaccaggtg tccctgacat gtctggtgaa gggcttttac      840

ccttccgata tcgccgtgga gtgggagtct aatggccagc cagagaacaa ttataagacc      900

acaccccctg tgctggactc cgatggctct ttcgccctgg tgtctaagct gaccgtggat      960

aagagcaggt ggcagcaggg caacgtgttt tcttgcagcg tgatgcacga ggccctgcac     1020

aatcactaca cacagaagtc cctgtctctg agccctggca ag                        1062


<210>  305
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE-755

(ZW1+2) anti-CD137 heavy chain AA

<400>  305

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu Asp 
145                 150                 155                 160 


Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg Gly 
225                 230                 235                 240 


Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Ser Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val 
    370                 375                 380                 


Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  306
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BE-755

(ZW1+2) anti-CD137 heavy chain DNA

<400>  306
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggata agggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcgggcg gcggagggag cgaggtgcag ctgcttgaga gtggtggagg tctggtccaa      420

ccaggaggtt cgctgcgttt atcctgcgcc gcgtctggat tcacggtttc cgccgaagac      480

gtgggttggg tgcgtcaagc gccggggaaa ggactggaat gggtctccgc catcttggat      540

aagggtggtt cgacatacta tgcggaaagt gtcaaagggc gctttacgat ctcgcgcgat      600

aacgcaaaaa atactcttta ccttcaaatg tctagccttc gtgctgagga cactgcggtg      660

tactactgcg cccgcattgt ctaccatgct ggtggtggcg tcacctttga tactcgggga      720

cagggcaccc aagtgaccgt gtccagcgag ccaaagtcct ccgacaagac ccacacatgc      780

ccaccttgtc cagcaccaga ggcagcagga ggaccatccg tgttcctgtt tccacccaag      840

cccaaggata ccctgatgat ctctcggacc cccgaggtga catgcgtggt ggtgagcgtg      900

tcccacgagg accctgaggt gaagttcaac tggtacgtgg atggcgtgga ggtgcacaat      960

gccaagacaa agccccggga ggagcagtac aacagcacct atagagtggt gtccgtgctg     1020

acagtgctgc accaggactg gctgaacggc aaggagtata agtgcaaggt gtctaataag     1080

gccctgcctg ccccaatcga gaagaccatc agcaaggcaa agggacagcc cagggagcct     1140

caggtgtacg tgtatcctcc aagccgcgac gagctgacca agaaccaggt gtccctgaca     1200

tgtctggtga agggctttta cccttccgat atcgccgtgg agtgggagtc taatggccag     1260

ccagagaaca attataagac cacaccccct gtgctggact ccgatggctc tttcgccctg     1320

gtgtctaagc tgaccgtgga taagagcagg tggcagcagg gcaacgtgtt ttcttgcagc     1380

gtgatgcacg aggccctgca caatcactac acacagaagt ccctgtctct gagccctggc     1440

aag                                                                   1443


<210>  307
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE-562 (E-mutFc) heavy chain AA

<400>  307

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
    130                 135                 140                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
145                 150                 155                 160 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                165                 170                 175     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            180                 185                 190         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        195                 200                 205             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    210                 215                 220                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
225                 230                 235                 240 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                245                 250                 255     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            260                 265                 270         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        275                 280                 285             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    290                 295                 300                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
305                 310                 315                 320 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                325                 330                 335     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            340                 345                 350         


Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
        355                 360                 365             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    370                 375                 380                 


Tyr Ile Phe Thr Ser Tyr Tyr Leu His Trp Val Arg Gln Ala Pro Gly 
385                 390                 395                 400 


Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr 
                405                 410                 415     


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
            420                 425                 430         


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        435                 440                 445             


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro 
    450                 455                 460                 


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
465                 470                 475                 480 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                485                 490                 495     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            500                 505                 510         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        515                 520                 525             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    530                 535                 540                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
545                 550                 555                 560 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                565                 570                 575     


Glu Pro Lys Ser Cys Asp 
            580         


<210>  308
<211>  1746
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BE-562 (E-mutFc) heavy chain DNA

<400>  308
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggata agggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcggagc caaagtcctc tgacaagacc cacacatgcc ccccttgtcc tgctccacca      420

gctgcaggac caagcgtgtt cctgtttcca cccaagccca aggataccct gatgatctct      480

cggaccccag aggtgacatg cgtggtggtg gatgtgagcc acgaggaccc cgaggtgaag      540

ttcaactggt atgtggacgg cgtggaggtg cacaatgcta agaccaagcc cagggaggag      600

cagtacaact ccacctatag agtggtgtct gtgctgacag tgctgcacca ggattggctg      660

aacggcaagg agtataagtg caaggtgtcc aataaggccc tggccgctcc tatcgagaag      720

accatctcta aggccaaggg ccagcccaga gagcctcagg tgtacacact gcctccatcc      780

cgggaagaga tgaccaagaa ccaggtgtct ctgacatgtc tggtcaaggg cttctatccc      840

tctgacatcg ccgtggagtg ggagagcaat ggccagcctg agaacaatta caagaccaca      900

ccccctgtgc tggattccga cggctctttc tttctgtata gcaagctgac cgtggacaag      960

tcccggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc tctgcataat     1020

cactatactc agaaatccct gtcactgtca cctggtaaag gtggaggcgg ttcacaggtg     1080

cagctggtgc agagcggcgc ggaagtgaaa aaaccgggcg cgagcgtgaa agtgagctgc     1140

aaagcgagcg gctatatttt taccagctat tacctgcatt gggtgcgcca ggcgccgggc     1200

cagggcctgg aatggattgg ctatattaac ccgcagaccg gcaagaccag ctatgcccag     1260

aaatttcagg gccgcgtgac catgacccgc gataccagca ccagcaccgt gtatatggaa     1320

ctgagcagcc tgcgcagcga agataccgcg gtgtattatt gcgcgcgcga atatggcaac     1380

tataactatc cgctggatta ttggggccag ggcaccctgg tgaccgtgag cagcgctagc     1440

accaaggggc cctcggtctt ccccctggca ccctcctcca agagtacttc tgggggcaca     1500

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac     1560

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     1620

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     1680

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct     1740

tgtgac                                                                1746


<210>  309
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE-375 (E-wtIgG1 Fc) heavy chain AA

<400>  309

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
            20                  25                  30          


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
        355                 360                 365             


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
    370                 375                 380                 


Gly Tyr Ile Phe Thr Ser Tyr Tyr Leu His Trp Val Arg Gln Ala Pro 
385                 390                 395                 400 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Gln Thr Gly Lys 
                405                 410                 415     


Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp 
            420                 425                 430         


Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
        435                 440                 445             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr 
    450                 455                 460                 


Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
465                 470                 475                 480 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
                485                 490                 495     


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            500                 505                 510         


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        515                 520                 525             


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    530                 535                 540                 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
545                 550                 555                 560 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
                565                 570                 575     


Val Glu Pro Lys Ser Cys Asp 
            580             


<210>  310
<211>  1749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BE-375 (E-wtIgG1 Fc) heavy chain DNA

<400>  310
gaggtccagt tacttgagag tggtggaggt ctggtccaac caggaggttc gctgcgttta       60

tcctgcgccg cgtctggatt cacggtttcc gccgaagacg tgggttgggt gcgtcaagcg      120

ccggggaaag gactggaatg ggtctccgcc atcttggata agggtggttc gacatactat      180

gcggaaagtg tcaaagggcg ctttacgatc tcgcgcgata acgcaaaaaa tactctttac      240

cttcaaatgt ctagccttcg tgctgaggac actgcggtgt actactgcgc ccgcattgtc      300

taccatgctg gtggtggcgt cacctttgat actcggggac agggcaccca agttacagtc      360

tcatcggagc ccaaatcttc tgacaaaact cacacatgcc caccgtgccc agcacctgaa      420

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      480

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      540

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      600

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      660

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      720

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      780

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      840

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      900

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      960

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1020

aaccactaca cgcagaagag cctctccctg tctccgggta aaggtggagg cggttcacag     1080

gtgcagctgg tgcagagcgg cgcggaagtg aaaaaaccgg gcgcgagcgt gaaagtgagc     1140

tgcaaagcga gcggctatat ttttaccagc tattacctgc attgggtgcg ccaggcgccg     1200

ggccagggcc tggaatggat tggctatatt aacccgcaga ccggcaagac cagctatgcc     1260

cagaaatttc agggccgcgt gaccatgacc cgcgatacca gcaccagcac cgtgtatatg     1320

gaactgagca gcctgcgcag cgaagatacc gcggtgtatt attgcgcgcg cgaatatggc     1380

aactataact atccgctgga ttattggggc cagggcaccc tggtgaccgt gagcagcgct     1440

agcaccaagg ggccctcggt cttccccctg gcaccctcct ccaagagtac ttctgggggc     1500

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg     1560

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga     1620

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     1680

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa     1740

tcttgtgac                                                             1749


<210>  311
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE-244 (A-(G4S)3) heavy chain AA

<400>  311

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
465                 470                 475                 480 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ala Glu 
                485                 490                 495     


Asp Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            500                 505                 510         


Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Val 
        515                 520                 525             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
    530                 535                 540                 


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
545                 550                 555                 560 


Ala Arg Ile Val Tyr His Ala Gly Gly Gly Val Thr Phe Asp Thr Arg 
                565                 570                 575     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            580                 585     


<210>  312
<211>  1758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BE-244 (A-(G4S)3) heavy chain DNA

<400>  312
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt caggcggcgg aggatctggt     1380

ggcggtgggt ccgaggtcca gttacttgag agtggtggag gtctggtcca accaggaggt     1440

tcgctgcgtt tatcctgcgc cgcgtctgga ttcacggttt ccgccgaaga cgtgggttgg     1500

gtgcgtcaag cgccggggaa aggactggaa tgggtctccg ccatcttgga taagggtggt     1560

tcgacatact atgcggaaag tgtcaaaggg cgctttacga tctcgcgcga taacgcaaaa     1620

aatactcttt accttcaaat gtctagcctt cgtgctgagg acactgcggt gtactactgc     1680

gcccgcattg tctaccatgc tggtggtggc gtcacctttg atactcgggg acagggcacc     1740

caagttacag tctcatcg                                                   1758


<210>  313
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE-146 heavy chain AA

<400>  313

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    450                 455                 460                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Phe Thr Val Ser Ala Glu Asp Val Gly Trp Val Arg Gln Ala Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Val Ser Ala Ile Leu Asp Lys Gly Gly Ser Thr 
            500                 505                 510         


Tyr Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        515                 520                 525             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    530                 535                 540                 


Thr Ala Val Tyr Tyr Cys Ala Arg Ile Val Tyr His Ala Gly Gly Gly 
545                 550                 555                 560 


Val Thr Phe Asp Thr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                565                 570                 575     


<210>  314
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BE-146

heavy chain

DNA

<400>  314
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360

gctagcacca aggggccctc ggtcttcccc ctggcaccct cctccaagag tacttctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagcca      660

aagtcctgtg acaagaccca cacatgcccc ccttgtcctg ctccaccagc tgcaggacca      720

agcgtgttcc tgtttccacc caagcccaag gataccctga tgatctctcg gaccccagag      780

gtgacatgcg tggtggtgga tgtgagccac gaggaccccg aggtgaagtt caactggtat      840

gtggacggcg tggaggtgca caatgctaag accaagccca gggaggagca gtacaactcc      900

acctatagag tggtgtctgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg gccgctccta tcgagaagac catctctaag     1020

gccaagggcc agcccagaga gcctcaggtg tacacactgc ctccatcccg ggaagagatg     1080

accaagaacc aggtgtctct gacatgtctg gtcaagggct tctatccctc tgacatcgcc     1140

gtggagtggg agagcaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gattccgacg gctctttctt tctgtatagc aagctgaccg tggacaagtc ccggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagctc tgcataatca ctatactcag     1320

aaatccctgt cactgtcacc tggtaaaggt ggaggcggtt cagaggtcca gttacttgag     1380

agtggtggag gtctggtcca accaggaggt tcgctgcgtt tatcctgcgc cgcgtctgga     1440

ttcacggttt ccgccgaaga cgtgggttgg gtgcgtcaag cgccggggaa aggactggaa     1500

tgggtctccg ccatcttgga taagggtggt tcgacatact atgcggaaag tgtcaaaggg     1560

cgctttacga tctcgcgcga taacgcaaaa aatactcttt accttcaaat gtctagcctt     1620

cgtgctgagg acactgcggt gtactactgc gcccgcattg tctaccatgc tggtggtggc     1680

gtcacctttg atactcgggg acagggcacc caagttacag tctcatcg                  1728


<210>  315
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tislelizumab VH

<400>  315

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  316
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tislelizumab VL

<400>  316

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  317
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  317

Gly Ser 
1       


<210>  318
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  318

Gly Gly Ser 
1           


<210>  319
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  319

Gly Ser Gly 
1           


<210>  320
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223> linker

<400>  320

Ser Gly Gly 
1           


<210>  321
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  321

Gly Gly Gly 
1           


<210>  322
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  322

Gly Gly Gly Ser 
1               


<210>  323
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  323

Ser Gly Gly Gly 
1               


<210>  324
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  324

Gly Gly Gly Gly Ser 
1               5   


<210>  325
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  325

Gly Gly Gly Gly Ser Gly Ser 
1               5           


<210>  326
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  326

Gly Gly Gly Gly Ser Gly Ser 
1               5           


<210>  327
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  327

Gly Gly Gly Gly Ser Gly Gly Ser 
1               5               


<210>  328
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  328

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  329
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  329

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  330
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  330

Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      


<210>  331
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  331

Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      


Val 
    


<210>  332
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  332

Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   


<210>  333
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  333

Ser Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   10  


<210>  334
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  334

Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      


Val 
    


<210>  335
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  335

Ser Ala Lys Thr Thr Pro 
1               5       


<210>  336
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  336

Ser Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   10  


<210>  337
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  337

Arg Ala Asp Ala Ala Pro 
1               5       


<210>  338
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  limker

<400>  338

Arg Ala Asp Ala Ala Pro Thr Val Ser 
1               5                   


<210>  339
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  339

Arg Ala Asp Ala Ala Ala Ala Gly Gly Pro Gly Ser 
1               5                   10          


<210>  340
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  340

Arg Ala Asp Ala Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25          


<210>  341
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  341

Ser Ala Lys Thr Thr Pro 
1               5       


<210>  342
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  342

Ser Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   10  


<210>  343
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  343

Ser Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
1               5                   10                  15      


Arg Val 
        


<210>  344
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  344

Ala Asp Ala Ala Pro 
1               5   


<210>  345
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  345

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
1               5                   10          


<210>  346
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  346

Thr Val Ala Ala Pro 
1               5   


<210>  347
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  347

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10          


<210>  348
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  348

Gln Pro Lys Ala Ala Pro 
1               5       


<210>  349
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  349

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
1               5                   10              


<210>  350
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  350

Ala Lys Thr Thr Pro Pro 
1               5       


<210>  351
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  351

Ala Lys Thr Thr Pro Pro Ser Val Thr Pro Leu Ala Pro 
1               5                   10              


<210>  352
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  352

Ala Lys Thr Thr Ala Pro 
1               5       


<210>  353
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  353

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
1               5                   10              


<210>  354
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  354

Ala Ser Thr Lys Gly Pro 
1               5       


<210>  355
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  355

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
1               5                   10              


<210>  356
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  356

Gly Glu Asn Lys Val Glu Tyr Ala Pro Ala Leu Met Ala Leu Ser 
1               5                   10                  15  


<210>  357
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  357

Gly Pro Ala Lys Glu Leu Thr Pro Leu Lys Glu Ala Lys Val Ser 
1               5                   10                  15  


<210>  358
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  358

Gly His Glu Ala Ala Ala Val Met Gln Val Gln Tyr Pro Ala Ser 
1               5                   10                  15  


