                         SEQUENCE LISTING

<110>  Alpha Cognition Inc.
 
<120>  GRANULIN/EPITHELIN MODULES AND COMBINATIONS THEREOF TO TREAT 
       NEURODEGENERATIVE DISEASE

<130>  2173/21WO

<150>  US63/191255
<151>  2021-05-20

<150>  US63/309118
<151>  2022-02-11

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


<210>  2
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Ile Gln Cys Pro Asp Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr 
1               5                   10                  15      


Cys Cys Val Met Val Asp Gly Ser Trp Gly Cys Cys Pro Met Pro Gln 
            20                  25                  30          


Ala Ser Cys Cys Glu Asp Arg Val His Cys Cys Pro His Gly Ala Phe 
        35                  40                  45              


Cys Asp Leu Val His Thr Arg Cys Ile 
    50                  55          


<210>  3
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  3

Val Met Cys Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys 
1               5                   10                  15      


Cys Glu Leu Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala 
            20                  25                  30          


Thr Cys Cys Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys 
        35                  40                  45              


Asp Leu Ile Gln Ser Lys Cys Leu 
    50                  55      


<210>  4
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Pro Cys Asp Asn Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys 
1               5                   10                  15      


Gln Leu Thr Ser Gly Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val 
            20                  25                  30          


Cys Cys Ser Asp His Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val 
        35                  40                  45              


Ala Glu Gly Gln Cys Gln 
    50                  


<210>  5
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Val Glu Cys Gly Glu Gly His Phe Cys His Asp Asn Gln Thr Cys 
1               5                   10                  15      


Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys Pro Tyr Arg Gln Gly 
            20                  25                  30          


Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro Ala Gly Phe Arg Cys 
        35                  40                  45              


Ala Ala Arg Gly Thr Lys Cys Leu 
    50                  55      


<210>  6
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Gly Pro Cys Gln Val Asp Ala His Cys Ser Ala Gly His Ser Cys 
1               5                   10                  15      


Ile Phe Thr Val Ser Gly Thr Ser Ser Cys Cys Pro Phe Pro Glu Ala 
            20                  25                  30          


Val Ala Cys Gly Asp Gly His His Cys Cys Pro Arg Gly Phe His Cys 
        35                  40                  45              


Ser Ala Asp Gly Arg Ser Cys Phe 
    50                  55      


<210>  7
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Val Lys Cys Asp Met Glu Val Ser Cys Pro Asp Gly Tyr Thr Cys 
1               5                   10                  15      


Cys Arg Leu Gln Ser Gly Ala Trp Gly Cys Cys Pro Phe Thr Gln Ala 
            20                  25                  30          


Val Cys Cys Glu Asp His Ile His Cys Cys Pro Ala Gly Phe Thr Cys 
        35                  40                  45              


Asp Thr Gln Lys Gly Thr Cys Glu Gln 
    50                  55          


<210>  8
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Ile Gly Cys Asp Gln His Thr Ser Cys Pro Val Gly Gln Thr Cys 
1               5                   10                  15      


Cys Pro Ser Leu Gly Gly Ser Trp Ala Cys Cys Gln Leu Pro His Ala 
            20                  25                  30          


Val Cys Cys Glu Asp Arg Gln His Cys Cys Pro Ala Gly Tyr Thr Cys 
        35                  40                  45              


Asn Val Lys Ala Arg Ser Cys Glu 
    50                  55      


<210>  9
<211>  2130
<212>  DNA
<213>  Homo sapiens

<400>  9
gctgctgccc aaggaccgcg gagtcggacg caggcagacc atgtggaccc tggtgagctg       60

ggtggcctta acagcagggc tggtggctgg aacgcggtgc ccagatggtc agttctgccc      120

tgtggcctgc tgcctggacc ccggaggagc cagctacagc tgctgccgtc cccttctgga      180

caaatggccc acaacactga gcaggcatct gggtggcccc tgccaggttg atgcccactg      240

ctctgccggc cactcctgca tctttaccgt ctcagggact tccagttgct gccccttccc      300

agaggccgtg gcatgcgggg atggccatca ctgctgccca cggggcttcc actgcagtgc      360

agacgggcga tcctgcttcc aaagatcagg taacaactcc gtgggtgcca tccagtgccc      420

tgatagtcag ttcgaatgcc cggacttctc cacgtgctgt gttatggtcg atggctcctg      480

ggggtgctgc cccatgcccc aggcttcctg ctgtgaagac agggtgcact gctgtccgca      540

cggtgccttc tgcgacctgg ttcacacccg ctgcatcaca cccacgggca cccaccccct      600

ggcaaagaag ctccctgccc agaggactaa cagggcagtg gccttgtcca gctcggtcat      660

gtgtccggac gcacggtccc ggtgccctga tggttctacc tgctgtgagc tgcccagtgg      720

gaagtatggc tgctgcccaa tgcccaacgc cacctgctgc tccgatcacc tgcactgctg      780

cccccaagac actgtgtgtg acctgatcca gagtaagtgc ctctccaagg agaacgctac      840

cacggacctc ctcactaagc tgcctgcgca cacagtgggg gatgtgaaat gtgacatgga      900

ggtgagctgc ccagatggct atacctgctg ccgtctacag tcgggggcct ggggctgctg      960

cccttttacc caggctgtgt gctgtgagga ccacatacac tgctgtcccg cggggtttac     1020

gtgtgacacg cagaagggta cctgtgaaca ggggccccac caggtgccct ggatggagaa     1080

ggccccagct cacctcagcc tgccagaccc acaagccttg aagagagatg tcccctgtga     1140

taatgtcagc agctgtccct cctccgatac ctgctgccaa ctcacgtctg gggagtgggg     1200

ctgctgtcca atcccagagg ctgtctgctg ctcggaccac cagcactgct gcccccaggg     1260

ctacacgtgt gtagctgagg ggcagtgtca gcgaggaagc gagatcgtgg ctggactgga     1320

gaagatgcct gcccgccggg cttccttatc ccaccccaga gacatcggct gtgaccagca     1380

caccagctgc ccggtggggc agacctgctg cccgagcctg ggtgggagct gggcctgctg     1440

ccagttgccc catgctgtgt gctgcgagga tcgccagcac tgctgcccgg ctggctacac     1500

ctgcaacgtg aaggctcgat cctgcgagaa ggaagtggtc tctgcccagc ctgccacctt     1560

cctggcccgt agccctcacg tgggtgtgaa ggacgtggag tgtggggaag gacacttctg     1620

ccatgataac cagacctgct gccgagacaa ccgacagggc tgggcctgct gtccctaccg     1680

ccagggcgtc tgttgtgctg atcggcgcca ctgctgtcct gctggcttcc gctgcgcagc     1740

caggggtacc aagtgtttgc gcagggaggc cccgcgctgg gacgcccctt tgagggaccc     1800

agccttgaga cagctgctgt gagggacagt actgaagact ctgcagccct cgggacccca     1860

ctcggagggt gccctctgct caggcctccc tagcacctcc ccctaaccaa attctccctg     1920

gaccccattc tgagctcccc atcaccatgg gaggtggggc ctcaatctaa ggccttccct     1980

gtcagaaggg ggttgtggca aaagccacat tacaagctgc catcccctcc ccgtttcagt     2040

ggaccctgtg gccaggtgct tttccctatc cacaggggtg tttgtgtgtg tgcgcgtgtg     2100

cgtttcaata aagtttgtac actttcttaa                                      2130


<210>  10
<211>  171
<212>  DNA
<213>  Homo sapiens

<400>  10
gccatccagt gccccgacag ccagttcgag tgccccgact tcagcacctg ctgcgtgatg       60

gtggacggca gctggggctg ctgccccatg ccccaggcca gctgctgcga ggacagggtg      120

cactgctgcc cccacggcgc cttctgcgac ctggtgcaca ccaggtgcat c               171


<210>  11
<211>  168
<212>  DNA
<213>  Homo sapiens

<400>  11
gtgatgtgcc ccgacgccag gagcaggtgc cccgacggca gcacctgctg cgagctgccc       60

agcggcaagt acggctgctg ccccatgccc aacgccacct gctgcagcga ccacctgcac      120

tgctgccccc aggacaccgt gtgcgacctg atccagagca agtgcctg                   168


<210>  12
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  12
gtgccctgcg acaacgtgag cagctgcccc agcagcgaca cctgctgcca gctgaccagc       60

ggcgagtggg gctgctgccc catccccgag gccgtgtgct gcagcgacca ccagcactgc      120

tgcccccagg gctacacctg cgtggccgag ggccagtgcc ag                         162


<210>  13
<211>  168
<212>  DNA
<213>  Homo sapiens

<400>  13
gacgtggagt gcggcgaggg ccacttctgc cacgacaacc agacctgctg cagggacaac       60

aggcagggct gggcctgctg cccctacagg cagggcgtgt gctgcgccga caggaggcac      120

tgctgccccg ccggcttcag gtgcgccgcc aggggcacca agtgcctg                   168


<210>  14
<211>  165
<212>  DNA
<213>  Homo sapiens

<400>  14
ggcccctgcc aggtggacgc ccactgcagc gccggccaca gctgcatctt caccgtgagc       60

ggcaccagca gctgctgccc cttccccgag gccgtggcct gcggcgacgg ccaccactgc      120

tgccccaggg gcttccactg cagcgccgac ggcaggagct gcttc                      165


<210>  15
<211>  165
<212>  DNA
<213>  Homo sapiens

<400>  15
gtgaagtgcg acatggaggt gagctgcccc gacggctaca cctgctgcag gctgcagagc       60

ggcgcctggg gctgctgccc cttcacccag gccgtgtgct gcgaggacca catccactgc      120

tgccccgccg gcttcacctg cgacacccag aagggcacct gcgag                      165


<210>  16
<211>  168
<212>  DNA
<213>  Homo sapiens

<400>  16
gacatcggct gcgaccagca caccagctgc cccgtgggcc agacctgctg ccccagcctg       60

ggcggcagct gggcctgctg ccagctgccc cacgccgtgt gctgcgagga caggcagcac      120

tgctgccccg ccggctacac ctgcaacgtg aaggccagga gctgcgag                   168


<210>  17
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal+GEM

<400>  17
atgtggaccc tggtgagctg ggtggccctg accgccggcc tggtggccgg ccagaggagc       60

ggcaacaaca gcgtgggcgc catccagtgc cccgacagcc agttcgagtg ccccgacttc      120

agcacctgct gcgtgatggt ggacggcagc tggggctgct gccccatgcc ccaggccagc      180

tgctgcgagg acagggtgca ctgctgcccc cacggcgcct tctgcgacct ggtgcacacc      240

aggtgcatct aa                                                          252


<210>  18
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal+GEM

<400>  18
atgtggaccc tggtgagctg ggtggccctg accgccggcc tggtggccgg cacccccacc       60

ggcacccacc ccctggccaa gaagctgccc gcccagagga ccaacagggc cgtggccctg      120

agcagcagcg tgatgtgccc cgacgccagg agcaggtgcc ccgacggcag cacctgctgc      180

gagctgccca gcggcaagta cggctgctgc cccatgccca acgccacctg ctgcagcgac      240

cacctgcact gctgccccca ggacaccgtg tgcgacctga tccagagcaa gtgcctgtaa      300


<210>  19
<211>  297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal+GEM

<400>  19
atgtggaccc tggtgagctg ggtggccctg accgccggcc tggtggccgg ccagggcccc       60

caccaggtgc cctggatgga gaaggccccc gcccacctga gcctgcccga cccccaggcc      120

ctgaagaggg acgtgccctg cgacaacgtg agcagctgcc ccagcagcga cacctgctgc      180

cagctgacca gcggcgagtg gggctgctgc cccatccccg aggccgtgtg ctgcagcgac      240

caccagcact gctgccccca gggctacacc tgcgtggccg agggccagtg ccagtaa         297


<210>  20
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal+GEM

<400>  20
atgtggaccc tggtgagctg ggtggccctg accgccggcc tggtggccgg caaggaggtg       60

gtgagcgccc agcccgccac cttcctggcc aggagccccc acgtgggcgt gaaggacgtg      120

gagtgcggcg agggccactt ctgccacgac aaccagacct gctgcaggga caacaggcag      180

ggctgggcct gctgccccta caggcagggc gtgtgctgcg ccgacaggag gcactgctgc      240

cccgccggct tcaggtgcgc cgccaggggc accaagtgcc tgtaa                      285


<210>  21
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal+GEM

<400>  21
atgtggaccc tggtgagctg ggtggccctg accgccggcc tggtggccgg caagtggccc       60

accaccctga gcaggcacct gggcggcccc tgccaggtgg acgcccactg cagcgccggc      120

cacagctgca tcttcaccgt gagcggcacc agcagctgct gccccttccc cgaggccgtg      180

gcctgcggcg acggccacca ctgctgcccc aggggcttcc actgcagcgc cgacggcagg      240

agctgcttct aa                                                          252


<210>  22
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal+GEM

<400>  22
atgtggaccc tggtgagctg ggtggccctg accgccggcc tggtggccgg cagcaaggag       60

aacgccacca ccgacctgct gaccaagctg cccgcccaca ccgtgggcga cgtgaagtgc      120

gacatggagg tgagctgccc cgacggctac acctgctgca ggctgcagag cggcgcctgg      180

ggctgctgcc ccttcaccca ggccgtgtgc tgcgaggacc acatccactg ctgccccgcc      240

ggcttcacct gcgacaccca gaagggcacc tgcgagtaa                             279


<210>  23
<211>  291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal+GEM

<400>  23
atgtggaccc tggtgagctg ggtggccctg accgccggcc tggtggccgg caggggcagc       60

gagatcgtgg ccggcctgga gaagatgccc gccaggaggg ccagcctgag ccaccccagg      120

gacatcggct gcgaccagca caccagctgc cccgtgggcc agacctgctg ccccagcctg      180

ggcggcagct gggcctgctg ccagctgccc cacgccgtgt gctgcgagga caggcagcac      240

tgctgccccg ccggctacac ctgcaacgtg aaggccagga gctgcgagta a               291


<210>  24
<211>  483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal+GEM

<400>  24
atgtggaccc tggtgagctg ggtggccctg accgccggcc tggtggccgg ccagaggagc       60

ggcaacaaca gcgtgggcgc catccagtgc cccgacagcc agttcgagtg ccccgacttc      120

agcacctgct gcgtgatggt ggacggcagc tggggctgct gccccatgcc ccaggccagc      180

tgctgcgagg acagggtgca ctgctgcccc cacggcgcct tctgcgacct ggtgcacacc      240

aggtgcatca aggaggtggt gagcgcccag cccgccacct tcctggccag gagcccccac      300

gtgggcgtga aggacgtgga gtgcggcgag ggccacttct gccacgacaa ccagacctgc      360

tgcagggaca acaggcaggg ctgggcctgc tgcccctaca ggcagggcgt gtgctgcgcc      420

gacaggaggc actgctgccc cgccggcttc aggtgcgccg ccaggggcac caagtgcctg      480

taa                                                                    483


<210>  25
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal+GEM

<400>  25
atgtggaccc tggtgagctg ggtggccctg accgccggcc tggtggccgg ccagaggagc       60

ggcaacaaca gcgtgggcgc catccagtgc cccgacagcc agttcgagtg ccccgacttc      120

agcacctgct gcgtgatggt ggacggcagc tggggctgct gccccatgcc ccaggccagc      180

tgctgcgagg acagggtgca ctgctgcccc cacggcgcct tctgcgacct ggtgcacacc      240

aggtgcatcc agggccccca ccaggtgccc tggatggaga aggcccccgc ccacctgagc      300

ctgcccgacc cccaggccct gaagagggac gtgccctgcg acaacgtgag cagctgcccc      360

agcagcgaca cctgctgcca gctgaccagc ggcgagtggg gctgctgccc catccccgag      420

gccgtgtgct gcagcgacca ccagcactgc tgcccccagg gctacacctg cgtggccgag      480

ggccagtgcc agaggggcag cgagatcgtg gccggcctgg agaagatgcc cgccaggagg      540

gccagcctga gccaccccag ggacatcggc tgcgaccagc acaccagctg ccccgtgggc      600

cagacctgct gccccagcct gggcggcagc tgggcctgct gccagctgcc ccacgccgtg      660

tgctgcgagg acaggcagca ctgctgcccc gccggctaca cctgcaacgt gaaggccagg      720

agctgcgaga aggaggtggt gagcgcccag cccgccacct tcctggccag gagcccccac      780

gtgggcgtga aggacgtgga gtgcggcgag ggccacttct gccacgacaa ccagacctgc      840

tgcagggaca acaggcaggg ctgggcctgc tgcccctaca ggcagggcgt gtgctgcgcc      900

gacaggaggc actgctgccc cgccggcttc aggtgcgccg ccaggggcac caagtgcctg      960

taa                                                                    963


<210>  26
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  26
atgtggaccc tggtgagctg ggtggccctg accgccggcc tggtggccgg c                51


<210>  27
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal + linker/leader + GEM F (GEM 1)

<400>  27

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
            20                  25                  30          


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
        35                  40                  45              


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
    50                  55                  60                  


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
65                  70                  75                  80  


Arg Cys Ile 
            


<210>  28
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal+linker+GEM

<400>  28

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro Ala Gln 
            20                  25                  30          


Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys Pro Asp 
        35                  40                  45              


Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu Pro Ser 
    50                  55                  60                  


Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys Ser Asp 
65                  70                  75                  80  


His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile Gln Ser 
                85                  90                  95      


Lys Cys Leu 
            


<210>  29
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal+linker+GEM

<400>  29

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His 
            20                  25                  30          


Leu Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp 
        35                  40                  45              


Asn Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser 
    50                  55                  60                  


Gly Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp 
65                  70                  75                  80  


His Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln 
                85                  90                  95      


Cys Gln 
        


<210>  30
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal+linker+GEM

<400>  30

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser 
            20                  25                  30          


Pro His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys 
        35                  40                  45              


His Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys 
    50                  55                  60                  


Cys Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys 
65                  70                  75                  80  


Pro Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu 
                85                  90                  


<210>  31
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal+linker+GEM

<400>  31

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Lys Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln 
            20                  25                  30          


Val Asp Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser 
        35                  40                  45              


Gly Thr Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp 
    50                  55                  60                  


Gly His His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg 
65                  70                  75                  80  


Ser Cys Phe 
            


<210>  32
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal+linker+GEM

<400>  32

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr Lys Leu Pro Ala 
            20                  25                  30          


His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val Ser Cys Pro Asp 
        35                  40                  45              


Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp Gly Cys Cys Pro 
    50                  55                  60                  


Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His Cys Cys Pro Ala 
65                  70                  75                  80  


Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                85                  90          


<210>  33
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal+linker+GEM

<400>  33

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            20                  25                  30          


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        35                  40                  45              


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    50                  55                  60                  


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
65                  70                  75                  80  


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                85                  90                  95      


<210>  34
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal+linker+GEM

<400>  34

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
            20                  25                  30          


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
        35                  40                  45              


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
    50                  55                  60                  


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
65                  70                  75                  80  


Arg Cys Ile Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala 
                85                  90                  95      


Arg Ser Pro His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His 
            100                 105                 110         


Phe Cys His Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp 
        115                 120                 125             


Ala Cys Cys Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His 
    130                 135                 140                 


Cys Cys Pro Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu 
145                 150                 155                 160 


<210>  35
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal+linker+GEM

<400>  35

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
            20                  25                  30          


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
        35                  40                  45              


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
    50                  55                  60                  


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
65                  70                  75                  80  


Arg Cys Ile Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro 
                85                  90                  95      


Ala His Leu Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro 
            100                 105                 110         


Cys Asp Asn Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu 
        115                 120                 125             


Thr Ser Gly Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys 
    130                 135                 140                 


Ser Asp His Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu 
145                 150                 155                 160 


Gly Gln Cys Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met 
                165                 170                 175     


Pro Ala Arg Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp 
            180                 185                 190         


Gln His Thr Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly 
        195                 200                 205             


Gly Ser Trp Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp 
    210                 215                 220                 


Arg Gln His Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg 
225                 230                 235                 240 


Ser Cys Glu Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala 
                245                 250                 255     


Arg Ser Pro His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His 
            260                 265                 270         


Phe Cys His Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp 
        275                 280                 285             


Ala Cys Cys Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His 
    290                 295                 300                 


Cys Cys Pro Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu 
305                 310                 315                 320 


<210>  36
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GEM

<400>  36

Ala Met Asp Ile Gly Cys Asp Gln His Thr Ser Cys Pro Val Gly Gln 
1               5                   10                  15      


Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp Ala Cys Cys Gln Leu Pro 
            20                  25                  30          


His Ala Val Cys Cys Glu Asp Arg Gln His Cys Cys Pro Ala Gly Tyr 
        35                  40                  45              


Thr Cys Asn Val Lys Ala Arg Ser Cys Glu Lys Leu Ala Ala Ala Leu 
    50                  55                  60                  


Glu His His His His His His 
65                  70      


<210>  37
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GEM

<400>  37

Ala Met Ala Ile Gln Cys Pro Asp Ser Gln Phe Glu Cys Pro Asp Phe 
1               5                   10                  15      


Ser Thr Cys Cys Val Met Val Asp Gly Ser Trp Gly Cys Cys Pro Met 
            20                  25                  30          


Pro Gln Ala Ser Cys Cys Glu Asp Arg Val His Cys Cys Pro His Gly 
        35                  40                  45              


Ala Phe Cys Asp Leu Val His Thr Arg Cys Ile Lys Leu Ala Ala Ala 
    50                  55                  60                  


Leu Glu His His His His His His 
65                  70          


<210>  38
<211>  6389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector

<400>  38
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgcg ttacataact      180

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaatagt      240

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      300

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      360

taaatggccc gcctggcatt gtgcccagta catgacctta tgggactttc ctacttggca      420

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt      480

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      540

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg      600

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc      660

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag      720

cgcgcggcgg gcgggagtcg ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc      780

ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga      840

cggcccttct cctccgggct gtaattagct gagcaagagg taagggttta agggatggtt      900

ggttggtggg gtattaatgt ttaattacct ggagcacctg cctgaaatca ctttttttca      960

ggttggcaag tttgtacaaa aaagcaggct gccaccatgt ggaccctggt gagctgggtg     1020

gccttaacag cagggctggt ggctggaacg cggtgcccag atggtcagtt ctgccctgtg     1080

gcctgctgcc tggaccccgg aggagccagc tacagctgct gccgtcccct tctggacaaa     1140

tggcccacaa cactgagcag gcatctgggt ggcccctgcc aggttgatgc ccactgctct     1200

gccggccact cctgcatctt taccgtctca gggacttcca gttgctgccc cttcccagag     1260

gccgtggcat gcggggatgg ccatcactgc tgcccacggg gcttccactg cagtgcagac     1320

gggcgatcct gcttccaaag atcaggtaac aactccgtgg gtgccatcca gtgccctgat     1380

agtcagttcg aatgcccgga cttctccacg tgctgtgtta tggtcgatgg ctcctggggg     1440

tgctgcccca tgccccaggc ttcctgctgt gaagacaggg tgcactgctg tccgcacggt     1500

gccttctgcg acctggttca cacccgctgc atcacaccca cgggcaccca ccccctggca     1560

aagaagctcc ctgcccagag gactaacagg gcagtggcct tgtccagctc ggtcatgtgt     1620

ccggacgcac ggtcccggtg ccctgatggt tctacctgct gtgagctgcc cagtgggaag     1680

tatggctgct gcccaatgcc caacgccacc tgctgctccg atcacctgca ctgctgcccc     1740

caagacactg tgtgtgacct gatccagagt aagtgcctct ccaaggagaa cgctaccacg     1800

gacctcctca ctaagctgcc tgcgcacaca gtgggggatg tgaaatgtga catggaggtg     1860

agctgcccag atggctatac ctgctgccgt ctacagtcgg gggcctgggg ctgctgccct     1920

tttacccagg ctgtgtgctg tgaggaccac atacactgct gtcccgcggg gtttacgtgt     1980

gacacgcaga agggtacctg tgaacagggg ccccaccagg tgccctggat ggagaaggcc     2040

ccagctcacc tcagcctgcc agacccacaa gccttgaaga gagatgtccc ctgtgataat     2100

gtcagcagct gtccctcctc cgatacctgc tgccaactca cgtctgggga gtggggctgc     2160

tgtccaatcc cagaggctgt ctgctgctcg gaccaccagc actgctgccc ccagggctac     2220

acgtgtgtag ctgaggggca gtgtcagcga ggaagcgaga tcgtggctgg actggagaag     2280

atgcctgccc gccgggcttc cttatcccac cccagagaca tcggctgtga ccagcacacc     2340

agctgcccgg tggggcagac ctgctgcccg agcctgggtg ggagctgggc ctgctgccag     2400

ttgccccatg ctgtgtgctg cgaggatcgc cagcactgct gcccggctgg ctacacctgc     2460

aacgtgaagg ctcgatcctg cgagaaggaa gtggtctctg cccagcctgc caccttcctg     2520

gcccgtagcc ctcacgtggg tgtgaaggac gtggagtgtg gggaaggaca cttctgccat     2580

gataaccaga cctgctgccg agacaaccga cagggctggg cctgctgtcc ctaccgccag     2640

ggcgtctgtt gtgctgatcg gcgccactgc tgtcctgctg gcttccgctg cgcagccagg     2700

ggtaccaagt gtttgcgcag ggaggccccg cgctgggacg cccctttgag ggacccagcc     2760

ttgagacagc tgctgtgaac ccagctttct tgtacaaagt gggaattccg ataatcaacc     2820

tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg ctccttttac     2880

gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc gtatggcttt     2940

cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt tgtggcccgt     3000

tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca ctggttgggg     3060

cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc ctattgccac     3120

ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac     3180

tgacaattcc gtggtgttgt cggggaagct gacgtccttt ccatggctgc tcgcctgtgt     3240

tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc     3300

ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg     3360

ccctcagacg agtcggatct ccctttgggc cgcctccccg catcgggaat tcctagagct     3420

cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc     3480

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa     3540

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac     3600

agcaaggggg aggattggga agagaatagc aggcatgctg gggagggccg caggaacccc     3660

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     3720

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     3780

gctgcctgca ggggcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac     3840

accgcatacg tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg     3900

ggtggtggtt acgcgcagcg tgaccgctac acttgccagc gccttagcgc ccgctccttt     3960

cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg     4020

ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga     4080

tttgggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac     4140

gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa cactcaactc     4200

tatctcgggc tattcttttg atttataagg gattttgccg atttcggtct attggttaaa     4260

aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat     4320

tttatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca     4380

cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag     4440

acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa     4500

acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat     4560

aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg     4620

tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat     4680

gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat     4740

tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt     4800

aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag     4860

cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa     4920

agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg     4980

ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct     5040

tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac     5100

tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca     5160

caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat     5220

accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact     5280

attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc     5340

ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga     5400

taaatctgga gccggtgagc gtggaagccg cggtatcatt gcagcactgg ggccagatgg     5460

taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg     5520

aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca     5580

agtttactca tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta     5640

ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca     5700

ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg     5760

cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga     5820

tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa     5880

tactgttctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc     5940

tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg     6000

tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac     6060

ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct     6120

acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc     6180

ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg     6240

gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg     6300

ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct     6360

ggccttttgc tggccttttg ctcacatgt                                       6389


<210>  39
<211>  6932
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector

<400>  39
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttgct cgacattgat      180

tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg      240

agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc      300

gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt      360

gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc      420

atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg      480

cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg      540

ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct      600

ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg      660

gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga      720

ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg      780

cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg ggagtcgctg      840

cgcgctgcct tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg ccccggctct      900

gactgaccgc gttactccca caggtgagcg ggcgggacgg cccttctcct ccgggctgta      960

attagcgctt ggtttaatga cggcttgttt cttttctgtg gctgcgtgaa agccttgagg     1020

ggctccggga gggccctttg tgcgggggga gcggctcggg gggtgcgtgc gtgtgtgtgt     1080

gcgtggggag cgccgcgtgc ggctccgcgc tgcccggcgg ctgtgagcgc tgcgggcgcg     1140

gcgcggggct ttgtgcgctc cgcagtgtgc gcgaggggag cgcggccggg ggcggtgccc     1200

cgcggtgcgg ggggggctgc gaggggaaca aaggctgcgt gcggggtgtg tgcgtggggg     1260

ggtgagcagg gggtgtgggc gcgtcggtcg ggctgcaacc ccccctgcac ccccctcccc     1320

gagttgctga gcacggcccg gcttcgggtg cggggctccg tacggggcgt ggcgcggggc     1380

tcgccgtgcc gggcgggggg tggcggcagg tgggggtgcc gggcggggcg gggccgcctc     1440

gggccgggga gggctcgggg gaggggcgcg gcggcccccg gagcgccggc ggctgtcgag     1500

gcgcggcgag ccgcagccat tgccttttat ggtaatcgtg cgagagggcg cagggacttc     1560

ctttgtccca aatctgtgcg gagccgaaat ctgggaggcg ccgccgcacc ccctctagcg     1620

ggcgcggggc gaagcggtgc ggcgccggca ggaaggaaat gggcggggag ggccttcgtg     1680

cgtcgccgcg ccgccgtccc cttctccctc tccagcctcg gggctgtccg cggggggacg     1740

gctgccttcg ggggggacgg ggcagggcgg ggttcggctt ctggcgtgtg accggcggct     1800

ctagagcctc tgctaaccat gttcatgcct tcttcttttt cctacagctc ctgggcaacg     1860

tgctggttat tgtgctgtct catcattttg gcaaagaatt gcaagtttgt acaaaaaagc     1920

aggctgccac catgtggacc ctggtgagct gggtggcctt aacagcaggg ctggtggctg     1980

gaacgcggtg cccagatggt cagttctgcc ctgtggcctg ctgcctggac cccggaggag     2040

ccagctacag ctgctgccgt ccccttctgg acaaatggcc cacaacactg agcaggcatc     2100

tgggtggccc ctgccaggtt gatgcccact gctctgccgg ccactcctgc atctttaccg     2160

tctcagggac ttccagttgc tgccccttcc cagaggccgt ggcatgcggg gatggccatc     2220

actgctgccc acggggcttc cactgcagtg cagacgggcg atcctgcttc caaagatcag     2280

gtaacaactc cgtgggtgcc atccagtgcc ctgatagtca gttcgaatgc ccggacttct     2340

ccacgtgctg tgttatggtc gatggctcct gggggtgctg ccccatgccc caggcttcct     2400

gctgtgaaga cagggtgcac tgctgtccgc acggtgcctt ctgcgacctg gttcacaccc     2460

gctgcatcac acccacgggc acccaccccc tggcaaagaa gctccctgcc cagaggacta     2520

acagggcagt ggccttgtcc agctcggtca tgtgtccgga cgcacggtcc cggtgccctg     2580

atggttctac ctgctgtgag ctgcccagtg ggaagtatgg ctgctgccca atgcccaacg     2640

ccacctgctg ctccgatcac ctgcactgct gcccccaaga cactgtgtgt gacctgatcc     2700

agagtaagtg cctctccaag gagaacgcta ccacggacct cctcactaag ctgcctgcgc     2760

acacagtggg ggatgtgaaa tgtgacatgg aggtgagctg cccagatggc tatacctgct     2820

gccgtctaca gtcgggggcc tggggctgct gcccttttac ccaggctgtg tgctgtgagg     2880

accacataca ctgctgtccc gcggggttta cgtgtgacac gcagaagggt acctgtgaac     2940

aggggcccca ccaggtgccc tggatggaga aggccccagc tcacctcagc ctgccagacc     3000

cacaagcctt gaagagagat gtcccctgtg ataatgtcag cagctgtccc tcctccgata     3060

cctgctgcca actcacgtct ggggagtggg gctgctgtcc aatcccagag gctgtctgct     3120

gctcggacca ccagcactgc tgcccccagg gctacacgtg tgtagctgag gggcagtgtc     3180

agcgaggaag cgagatcgtg gctggactgg agaagatgcc tgcccgccgg gcttccttat     3240

cccaccccag agacatcggc tgtgaccagc acaccagctg cccggtgggg cagacctgct     3300

gcccgagcct gggtgggagc tgggcctgct gccagttgcc ccatgctgtg tgctgcgagg     3360

atcgccagca ctgctgcccg gctggctaca cctgcaacgt gaaggctcga tcctgcgaga     3420

aggaagtggt ctctgcccag cctgccacct tcctggcccg tagccctcac gtgggtgtga     3480

aggacgtgga gtgtggggaa ggacacttct gccatgataa ccagacctgc tgccgagaca     3540

accgacaggg ctgggcctgc tgtccctacc gccagggcgt ctgttgtgct gatcggcgcc     3600

actgctgtcc tgctggcttc cgctgcgcag ccaggggtac caagtgtttg cgcagggagg     3660

ccccgcgctg ggacgcccct ttgagggacc cagccttgag acagctgctg tgaatcgaat     3720

tctcgagata atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac     3780

tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt     3840

gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttagt tcttgccacg     3900

gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact     3960

gacaattccg tggtgaccca gctttcttgt acaaagtggg aattcctaga gctcgctgat     4020

cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt     4080

ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat     4140

cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg     4200

gggaggattg ggaagagaat agcaggcatg ctggggaggg ccgcaggaac ccctagtgat     4260

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     4320

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct     4380

gcaggggcgc ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat     4440

acgtcaaagc aaccatagta cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4500

gttacgcgca gcgtgaccgc tacacttgcc agcgccttag cgcccgctcc tttcgctttc     4560

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc     4620

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgatttgggt     4680

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4740

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ctctatctcg     4800

ggctattctt ttgatttata agggattttg ccgatttcgg tctattggtt aaaaaatgag     4860

ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgtttac aattttatgg     4920

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca     4980

acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct     5040

gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg     5100

agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt     5160

tcttagacgt cctggcccgt gtctcaaaat ctctgatgtt acattgcaca agataaaaat     5220

atatcatcat gaacaataaa actgtctgct tacataaaca gtaatacaag gggtgttatg     5280

agccatattc aacgggaaac gtcgaggccg cgattaaatt ccaacatgga tgctgattta     5340

tatgggtata aatgggctcg cgataatgtc gggcaatcag gtgcgacaat ctatcgcttg     5400

tatgggaagc ccgatgcgcc agagttgttt ctgaaacatg gcaaaggtag cgttgccaat     5460

gatgttacag atgagatggt cagactaaac tggctgacgg aatttatgcc tcttccgacc     5520

atcaagcatt ttatccgtac tcctgatgat gcatggttac tcaccactgc gatccccgga     5580

aaaacagcat tccaggtatt agaagaatat cctgattcag gtgaaaatat tgttgatgcg     5640

ctggcagtgt tcctgcgccg gttgcattcg attcctgttt gtaattgtcc ttttaacagc     5700

gatcgcgtat ttcgtctcgc tcaggcgcaa tcacgaatga ataacggttt ggttgatgcg     5760

agtgattttg atgacgagcg taatggctgg cctgttgaac aagtctggaa agaaatgcat     5820

aaacttttgc cattctcacc ggattcagtc gtcactcatg gtgatttctc acttgataac     5880

cttatttttg acgaggggaa attaataggt tgtattgatg ttggacgagt cggaatcgca     5940

gaccgatacc aggatcttgc catcctatgg aactgcctcg gtgagttttc tccttcatta     6000

cagaaacggc tttttcaaaa atatggtatt gataatcctg atatgaataa attgcagttt     6060

catttgatgc tcgatgagtt tttctatcag aattggttaa ttggttgtaa cactggcaga     6120

gcattacgct gacttgacgg gacggcgcaa gctcatgacc aaaatccctt aacgtgagtt     6180

acgcgtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     6240

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     6300

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     6360

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     6420

aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     6480

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     6540

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     6600

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     6660

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     6720

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     6780

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     6840

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     6900

cctggccttt tgctggcctt ttgctcacat gt                                   6932


