                         SEQUENCE LISTING

<110>  Vancouver Biotech Ltd.
 
<120>  Applications of GHR106 Monoclonal Antibody as a GnRH Antagonist

<130>  V101 0043/JAM

<150>  US63/189852
<151>  2021-05-18

<150>  US63/242976
<151>  2021-09-10

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Asn Ser Ala Ser Pro Glu Gln Asn Gln Asn His Cys Ser Ala 
1               5                   10                  15      


Ile Asn Asn Ser Ile Pro Leu Met Gln Gly Asn Leu Pro Thr 
            20                  25                  30  


<210>  2
<211>  30
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  2

Met Glu Asn Ser Ala Ser Pro Glu Gln Asn Gln Asn His Cys Ser Ala 
1               5                   10                  15      


Ile Asn Asn Ser Ile Pro Leu Thr Gln Gly Asn Leu Asn Thr 
            20                  25                  30  


<210>  3
<211>  30
<212>  PRT
<213>  Pan troglodytes

<400>  3

Met Ala Asn Ser Ala Leu Pro Glu Gln Asn Gln Asn His Cys Ser Val 
1               5                   10                  15      


Ile Asn Asn Ser Ile Pro Leu Met Gln Gly Asn Leu Pro Thr 
            20                  25                  30  


<210>  4
<211>  29
<212>  PRT
<213>  Felis catus

<400>  4

Met Ala Ser Ala Pro Pro Glu Gln Asn Gln Asn His Cys Ser Ala Ile 
1               5                   10                  15      


Asn Asn Ser Ile Pro Leu Met Gln Gly Asn Leu Pro Thr 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  Canis familiaris

<400>  5

Met Ala Ser Ala Ser Pro Glu Gln Asn Gln Asn His Cys Ser Ala Val 
1               5                   10                  15      


Asn Asn Ser Asn Met Leu Met Gln Gly Asn Leu Pro Thr 
            20                  25                  


<210>  6
<211>  30
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Asn Asn Ala Ser Leu Glu Gln Asp Pro Asn His Cys Ser Ala 
1               5                   10                  15      


Ile Asn Asn Ser Ile Pro Leu Ile Gln Gly Lys Leu Pro Thr 
            20                  25                  30  


<210>  7
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Construct

<400>  7

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Gln Glu Ser Gly 
            20                  25                  30          


Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val 
        35                  40                  45              


Ser Gly Phe Ser Leu Ser Arg Tyr Ser Val His Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Met Ile Trp Gly Gly Gly Ser 
65                  70                  75                  80  


Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Lys Asp 
                85                  90                  95      


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Asn Asp Gly Tyr Tyr Ser 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
    210                 215                 220                 


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Leu Gly 
465             


<210>  8
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Construct

<400>  8

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Lys Gln Ser Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Construct

<400>  9

Arg Tyr Ser Val His 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Construct

<400>  10

Met Ile Trp Gly Gly Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


Arg 
    


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Construct

<400>  11

Gly Tyr Tyr Ser Phe Ala 
1               5       


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Construct

<400>  12

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Construct

<400>  13

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Construct

<400>  14

Lys Gln Ser Tyr Asn Leu Tyr Thr 
1               5               


