                               SEQUENCE LISTING

<110> BAYLOR COLLEGE OF MEDICINE
      WILLIAM MARSH RICE UNIVERSITY
 
<120> A SYNTHETIC CIRCUIT FOR BUFFERING GENE DOSAGE VARIATION BETWEEN 
      INDIVIDUAL MAMMALIAN CELLS

<130> BAYM.P0339WO-1001210391

<140> PCT/US2022/072286
<141> 2022-05-12

<150> 63/187,704
<151> 2021-05-12

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(3)
<223> This region may or may not be present

<400> 1
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 2
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(3)
<223> This region may or may not be present

<400> 2
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 3
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(3)
<223> This region may or may not be present

<400> 3
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 4
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(3)
<223> This region may or may not be present

<400> 4
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210> 5
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
acatctgtgg cttcactatt taattaaaga cttcaagcgg cgctcactgt caacagcac        59


<210> 6
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
tgaagccaca gatgtattta attaaagact tcaagcggtg cctactgcct cggagaatt        59


<210> 7
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 8
<211> 7978
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcatccctat cagtgataga gatcagatct      840

ccctatcagt gatagagagc tgttttgacc tccatagaag acaccgggac cgatccagcc      900

tccggactct agcgtttaaa cttaagctgg gtacccgggg atcctctagg gcctctgagc      960

tattccagaa gtagtgaaga ggcttttttg gaggcctagg cttttgcaaa aagctccgga     1020

tcgatcctga gaacttcagg gtgagtttgg ggacccttga ttgttctttc tttttcgcta     1080

ttgtaaaatt catgttatat ggagggggca aagttttcag ggtgttgttt agaatgggaa     1140

gatgtccctt gtatcaccat ggaccctcat gataattttg tttctttcac tttctactct     1200

gttgacaacc attgtctcct cttattttct tttcattttc tgtaactttt tcgttaaact     1260

ttagcttgca tttgtaacga atttttaaat tcacttttgt ttatttgtca gattgtaagt     1320

actttctcta atcacttttt tttcaaggca atcagggtat attatattgt acttcagcac     1380

agttttagag aacaattgtt ataattaaat gataaggtag aatatttctg catataaatt     1440

ctggctggcg tggaaatatt cttattggta gaaacaacta catcctggtc atcatcctgc     1500

ctttctcttt atggttacaa tgatatacac tgtttgagat gaggataaaa tactctgagt     1560

ccaaaccggg cccctctgct aaccatgttc atgccttctt ctttttccta caggtcctgc     1620

aggcgccacc atggagtcta gactggacaa gagcaaagtc ataaactctg ctctggaatt     1680

actcaatgaa gtcggtatcg aaggcctgac gacaaggaaa ctcgctcaaa agctgggagt     1740

tgagcagcct accctgtact ggcacgtgaa gaacaagcgg gccctgctcg atgccctggc     1800

aatcgagatg ctggacaggc atcataccca cttctgcccc ctggaaggcg agtcatggca     1860

agactttctg cggaacaacg ccaagtcatt ccgctgtgct ctcctctcac atcgcgacgg     1920

ggctaaagtg catctcggca cccgcccaac agagaaacag tacgaaaccc tggaaaatca     1980

gctcgcgttc ctgtgtcagc aaggcttctc cctggagaac gcactgtacg ctctgtccgc     2040

cgtgggccac tttacactgg gctgcgtatt ggaggatcag gagcatcaag tagcaaaaga     2100

ggaaagagag acacctacca ccgattctat gcccccactt ctgagacaag caattgagct     2160

gttcgaccat cagggagccg aacctgcctt ccttttcggc ctggaactaa tcatatgtgg     2220

cctggagaaa cagctaaagt gcgaaagcgg cgggccaaaa aagaagagaa agggtgacgg     2280

tgctggttta attaacatgg gaagcggagc tactaacttc agcctgctga agcaggctgg     2340

agacgtggag gagaaccctg gacctgctag catggtgagc aagggcgagg agctgttcac     2400

cggggtggtg cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt     2460

gtccggcgag ggcgagggcg atgccaccta cggcaagctg accctgaagt tcatctgcac     2520

caccggcaag ctgcccgtgc cctggcccac cctcgtgacc accctgacct acggcgtgca     2580

gtgcttcagc cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc     2640

cgaaggctac gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg     2700

cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga     2760

cttcaaggag gacggcaaca tcctggggca caagctggag tacaactaca acagccacaa     2820

cgtctatatc atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca     2880

caacatcgag gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg     2940

cgacggcccc gtgctgctgc ccgacaacca ctacctgagc acccagtccg ccctgagcaa     3000

agaccccaac gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat     3060

cactctcggc atggacgagc tgtacaagta gaacgatatg ggctgaatac aaaaagcttg     3120

tgagtatgtg ctcgcttcgg cagcacatat actatgtcga atgaggcttc agtactttac     3180

agaatcgttg cctgcacatc ttggaaacac ttgctgggat tacttcttca ggttaaccca     3240

acagaaggct cgagtgctgt tgacagtgag cgcacgatat gggctgaata caaatagtga     3300

agccacagat gtatttgtat tcagcccata tcgtttgcct actgcctcgg agaattcaag     3360

gggctacttt aggagcaatt atcttgttta ctaaaactga ataccttgct atctctttga     3420

tacattttta caaagctgaa ttaaaatggt ataaattaaa tcactttttt caattgtttc     3480

cttttttttc ctcaggcggc cgcaatcaac ctctggatta caaaatttgt gaaagattga     3540

ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt     3600

tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt     3660

tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg     3720

tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg     3780

ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc     3840

gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcctcgagtc     3900

tagagggccc gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt gccagccatc     3960

tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     4020

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg     4080

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg     4140

ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc agctggggct ctagggggta     4200

tccccacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt     4260

gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct     4320

cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg     4380

atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtac     4440

ctagaagttc ctattccgaa gttcctattc tctagaaagt ataggaactt ccttggccaa     4500

aaagcctgaa ctcaccgcga cgtctgtcga gaagtttctg atcgaaaagt tcgacagcgt     4560

ctccgacctg atgcagctct cggagggcga agaatctcgt gctttcagct tcgatgtagg     4620

agggcgtgga tatgtcctgc gggtaaatag ctgcgccgat ggtttctaca aagatcgtta     4680

tgtttatcgg cactttgcat cggccgcgct cccgattccg gaagtgcttg acattgggga     4740

attcagcgag agcctgacct attgcatctc ccgccgtgca cagggtgtca cgttgcaaga     4800

cctgcctgaa accgaactgc ccgctgttct gcagccggtc gcggaggcca tggatgcgat     4860

cgctgcggcc gatcttagcc agacgagcgg gttcggccca ttcggaccgc aaggaatcgg     4920

tcaatacact acatggcgtg atttcatatg cgcgattgct gatccccatg tgtatcactg     4980

gcaaactgtg atggacgaca ccgtcagtgc gtccgtcgcg caggctctcg atgagctgat     5040

gctttgggcc gaggactgcc ccgaagtccg gcacctcgtg cacgcggatt tcggctccaa     5100

caatgtcctg acggacaatg gccgcataac agcggtcatt gactggagcg aggcgatgtt     5160

cggggattcc caatacgagg tcgccaacat cttcttctgg aggccgtggt tggcttgtat     5220

ggagcagcag acgcgctact tcgagcggag gcatccggag cttgcaggat cgccgcggct     5280

ccgggcgtat atgctccgca ttggtcttga ccaactctat cagagcttgg ttgacggcaa     5340

tttcgatgat gcagcttggg cgcagggtcg atgcgacgca atcgtccgat ccggagccgg     5400

gactgtcggg cgtacacaaa tcgcccgcag aagcgcggcc gtctggaccg atggctgtgt     5460

agaagtactc gccgatagtg gaaaccgacg ccccagcact cgtccgaggg caaaggaata     5520

gcacgtacta cgagatttcg attccaccgc cgccttctat gaaaggttgg gcttcggaat     5580

cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc tggagttctt     5640

cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac     5700

aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat     5760

caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg cgtaatcatg     5820

gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc     5880

cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc     5940

gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat     6000

cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac     6060

tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt     6120

aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca     6180

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc     6240

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     6300

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     6360

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     6420

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     6480

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     6540

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     6600

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag     6660

aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg     6720

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca     6780

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     6840

tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag     6900

gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata     6960

tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat     7020

ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg     7080

ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc     7140

tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc     7200

aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc     7260

gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc     7320

gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc     7380

ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa     7440

gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat     7500

gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata     7560

gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca     7620

tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag     7680

gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc     7740

agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc     7800

aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata     7860

ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta     7920

gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtc       7978


<210> 9
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 10
<211> 7978
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcatccctat cagtgataga gatcagatct      840

ccctatcagt gatagagagc tgttttgacc tccatagaag acaccgggac cgatccagcc      900

tccggactct agcgtttaaa cttaagctgg gtacccgggg atcctctagg gcctctgagc      960

tattccagaa gtagtgaaga ggcttttttg gaggcctagg cttttgcaaa aagctccgga     1020

tcgatcctga gaacttcagg gtgagtttgg ggacccttga ttgttctttc tttttcgcta     1080

ttgtaaaatt catgttatat ggagggggca aagttttcag ggtgttgttt agaatgggaa     1140

gatgtccctt gtatcaccat ggaccctcat gataattttg tttctttcac tttctactct     1200

gttgacaacc attgtctcct cttattttct tttcattttc tgtaactttt tcgttaaact     1260

ttagcttgca tttgtaacga atttttaaat tcacttttgt ttatttgtca gattgtaagt     1320

actttctcta atcacttttt tttcaaggca atcagggtat attatattgt acttcagcac     1380

agttttagag aacaattgtt ataattaaat gataaggtag aatatttctg catataaatt     1440

ctggctggcg tggaaatatt cttattggta gaaacaacta catcctggtc atcatcctgc     1500

ctttctcttt atggttacaa tgatatacac tgtttgagat gaggataaaa tactctgagt     1560

ccaaaccggg cccctctgct aaccatgttc atgccttctt ctttttccta caggtcctgc     1620

aggcgccacc atggagtcta gactggacaa gagcaaagtc ataaactctg ctctggaatt     1680

actcaatgaa gtcggtatcg aaggcctgac gacaaggaaa ctcgctcaaa agctgggagt     1740

tgagcagcct accctgtact ggcacgtgaa gaacaagcgg gccctgctcg atgccctggc     1800

aatcgagatg ctggacaggc atcataccca cttctgcccc ctggaaggcg agtcatggca     1860

agactttctg cggaacaacg ccaagtcatt ccgctgtgct ctcctctcac atcgcgacgg     1920

ggctaaagtg catctcggca cccgcccaac agagaaacag tacgaaaccc tggaaaatca     1980

gctcgcgttc ctgtgtcagc aaggcttctc cctggagaac gcactgtacg ctctgtccgc     2040

cgtgggccac tttacactgg gctgcgtatt ggaggatcag gagcatcaag tagcaaaaga     2100

ggaaagagag acacctacca ccgattctat gcccccactt ctgagacaag caattgagct     2160

gttcgaccat cagggagccg aacctgcctt ccttttcggc ctggaactaa tcatatgtgg     2220

cctggagaaa cagctaaagt gcgaaagcgg cgggccaaaa aagaagagaa agggtgacgg     2280

tgctggttta attaacatgg gaagcggagc tactaacttc agcctgctga agcaggctgg     2340

agacgtggag gagaaccctg gacctgctag catggtgagc aagggcgagg agctgttcac     2400

cggggtggtg cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt     2460

gtccggcgag ggcgagggcg atgccaccta cggcaagctg accctgaagt tcatctgcac     2520

caccggcaag ctgcccgtgc cctggcccac cctcgtgacc accctgacct acggcgtgca     2580

gtgcttcagc cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc     2640

cgaaggctac gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg     2700

cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga     2760

cttcaaggag gacggcaaca tcctggggca caagctggag tacaactaca acagccacaa     2820

cgtctatatc atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca     2880

caacatcgag gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg     2940

cgacggcccc gtgctgctgc ccgacaacca ctacctgagc acccagtccg ccctgagcaa     3000

agaccccaac gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat     3060

cactctcggc atggacgagc tgtacaagta gccgcttgaa gtctttaatt aaaaagcttg     3120

tgagtatgtg ctcgcttcgg cagcacatat actatgtcga atgaggcttc agtactttac     3180

agaatcgttg cctgcacatc ttggaaacac ttgctgggat tacttcttca ggttaaccca     3240

acagaaggct cgagtgctgt tgacagtgag cgccgcttga agtctttaat taaatagtga     3300

agccacagat gtatttaatt aaagacttca agcggtgcct actgcctcgg agaattcaag     3360

gggctacttt aggagcaatt atcttgttta ctaaaactga ataccttgct atctctttga     3420

tacattttta caaagctgaa ttaaaatggt ataaattaaa tcactttttt caattgtttc     3480

cttttttttc ctcaggcggc cgcaatcaac ctctggatta caaaatttgt gaaagattga     3540

ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt     3600

tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt     3660

tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg     3720

tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg     3780

ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc     3840

gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcctcgagtc     3900

tagagggccc gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt gccagccatc     3960

tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     4020

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg     4080

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg     4140

ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc agctggggct ctagggggta     4200

tccccacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt     4260

gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct     4320

cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg     4380

atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtac     4440

ctagaagttc ctattccgaa gttcctattc tctagaaagt ataggaactt ccttggccaa     4500

aaagcctgaa ctcaccgcga cgtctgtcga gaagtttctg atcgaaaagt tcgacagcgt     4560

ctccgacctg atgcagctct cggagggcga agaatctcgt gctttcagct tcgatgtagg     4620

agggcgtgga tatgtcctgc gggtaaatag ctgcgccgat ggtttctaca aagatcgtta     4680

tgtttatcgg cactttgcat cggccgcgct cccgattccg gaagtgcttg acattgggga     4740

attcagcgag agcctgacct attgcatctc ccgccgtgca cagggtgtca cgttgcaaga     4800

cctgcctgaa accgaactgc ccgctgttct gcagccggtc gcggaggcca tggatgcgat     4860

cgctgcggcc gatcttagcc agacgagcgg gttcggccca ttcggaccgc aaggaatcgg     4920

tcaatacact acatggcgtg atttcatatg cgcgattgct gatccccatg tgtatcactg     4980

gcaaactgtg atggacgaca ccgtcagtgc gtccgtcgcg caggctctcg atgagctgat     5040

gctttgggcc gaggactgcc ccgaagtccg gcacctcgtg cacgcggatt tcggctccaa     5100

caatgtcctg acggacaatg gccgcataac agcggtcatt gactggagcg aggcgatgtt     5160

cggggattcc caatacgagg tcgccaacat cttcttctgg aggccgtggt tggcttgtat     5220

ggagcagcag acgcgctact tcgagcggag gcatccggag cttgcaggat cgccgcggct     5280

ccgggcgtat atgctccgca ttggtcttga ccaactctat cagagcttgg ttgacggcaa     5340

tttcgatgat gcagcttggg cgcagggtcg atgcgacgca atcgtccgat ccggagccgg     5400

gactgtcggg cgtacacaaa tcgcccgcag aagcgcggcc gtctggaccg atggctgtgt     5460

agaagtactc gccgatagtg gaaaccgacg ccccagcact cgtccgaggg caaaggaata     5520

gcacgtacta cgagatttcg attccaccgc cgccttctat gaaaggttgg gcttcggaat     5580

cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc tggagttctt     5640

cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac     5700

aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat     5760

caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg cgtaatcatg     5820

gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc     5880

cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc     5940

gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat     6000

cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac     6060

tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt     6120

aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca     6180

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc     6240

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     6300

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     6360

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     6420

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     6480

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     6540

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     6600

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag     6660

aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg     6720

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca     6780

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     6840

tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag     6900

gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata     6960

tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat     7020

ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg     7080

ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc     7140

tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc     7200

aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc     7260

gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc     7320

gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc     7380

ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa     7440

gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat     7500

gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata     7560

gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca     7620

tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag     7680

gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc     7740

agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc     7800

aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata     7860

ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta     7920

gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtc       7978


<210> 11
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 12
<211> 8000
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcatccctat cagtgataga gatcagatct      840

ccctatcagt gatagagagc tgttttgacc tccatagaag acaccgggac cgatccagcc      900

tccggactct agcgtttaaa cttaagctgg gtacccgggg atcctctagg gcctctgagc      960

tattccagaa gtagtgaaga ggcttttttg gaggcctagg cttttgcaaa aagctccgga     1020

tcgatcctga gaacttcagg gtgagtttgg ggacccttga ttgttctttc tttttcgcta     1080

ttgtaaaatt catgttatat ggagggggca aagttttcag ggtgttgttt agaatgggaa     1140

gatgtccctt gtatcaccat ggaccctcat gataattttg tttctttcac tttctactct     1200

gttgacaacc attgtctcct cttattttct tttcattttc tgtaactttt tcgttaaact     1260

ttagcttgca tttgtaacga atttttaaat tcacttttgt ttatttgtca gattgtaagt     1320

actttctcta atcacttttt tttcaaggca atcagggtat attatattgt acttcagcac     1380

agttttagag aacaattgtt ataattaaat gataaggtag aatatttctg catataaatt     1440

ctggctggcg tggaaatatt cttattggta gaaacaacta catcctggtc atcatcctgc     1500

ctttctcttt atggttacaa tgatatacac tgtttgagat gaggataaaa tactctgagt     1560

ccaaaccggg cccctctgct aaccatgttc atgccttctt ctttttccta caggtcctgc     1620

accgcttgaa gtctttaatt aaaggcgcca ccatggagtc tagactggac aagagcaaag     1680

tcataaactc tgctctggaa ttactcaatg aagtcggtat cgaaggcctg acgacaagga     1740

aactcgctca aaagctggga gttgagcagc ctaccctgta ctggcacgtg aagaacaagc     1800

gggccctgct cgatgccctg gcaatcgaga tgctggacag gcatcatacc cacttctgcc     1860

ccctggaagg cgagtcatgg caagactttc tgcggaacaa cgccaagtca ttccgctgtg     1920

ctctcctctc acatcgcgac ggggctaaag tgcatctcgg cacccgccca acagagaaac     1980

agtacgaaac cctggaaaat cagctcgcgt tcctgtgtca gcaaggcttc tccctggaga     2040

acgcactgta cgctctgtcc gccgtgggcc actttacact gggctgcgta ttggaggatc     2100

aggagcatca agtagcaaaa gaggaaagag agacacctac caccgattct atgcccccac     2160

ttctgagaca agcaattgag ctgttcgacc atcagggagc cgaacctgcc ttccttttcg     2220

gcctggaact aatcatatgt ggcctggaga aacagctaaa gtgcgaaagc ggcgggccaa     2280

aaaagaagag aaagggtgac ggtgctggtt taattaacat gggaagcgga gctactaact     2340

tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacctgct agcatggtga     2400

gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg     2460

taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc     2520

tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga     2580

ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg     2640

acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg     2700

acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc     2760

gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg     2820

agtacaacta caacagccac aacgtctata tcatggccga caagcagaag aacggcatca     2880

aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact     2940

accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga     3000

gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg     3060

agttcgtgac cgccgccggg atcactctcg gcatggacga gctgtacaag tagccgcttg     3120

aagtctttaa ttaaaaagct tgtgagtatg tgctcgcttc ggcagcacat atactatgtc     3180

gaatgaggct tcagtacttt acagaatcgt tgcctgcaca tcttggaaac acttgctggg     3240

attacttctt caggttaacc caacagaagg ctcgagtgct gttgacagtg agcgccgctt     3300

gaagtcttta attaaatagt gaagccacag atgtatttaa ttaaagactt caagcggtgc     3360

ctactgcctc ggagaattca aggggctact ttaggagcaa ttatcttgtt tactaaaact     3420

gaataccttg ctatctcttt gatacatttt tacaaagctg aattaaaatg gtataaatta     3480

aatcactttt ttcaattgtt tccttttttt tcctcaggcg gccgcaatca acctctggat     3540

tacaaaattt gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt     3600

ggatacgctg ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc     3660

tcctccttgt ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg     3720

caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc     3780

accacctgtc agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa     3840

ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat     3900

tccgtggtgt tgtcctcgag tctagagggc ccgtttaaac ccgctgatca gcctcgactg     3960

tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg     4020

aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga     4080

gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg     4140

aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag gcggaaagaa     4200

ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta agcgcggcgg     4260

gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt     4320

tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc     4380

gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg     4440

attagggtga tggttcacgt acctagaagt tcctattccg aagttcctat tctctagaaa     4500

gtataggaac ttccttggcc aaaaagcctg aactcaccgc gacgtctgtc gagaagtttc     4560

tgatcgaaaa gttcgacagc gtctccgacc tgatgcagct ctcggagggc gaagaatctc     4620

gtgctttcag cttcgatgta ggagggcgtg gatatgtcct gcgggtaaat agctgcgccg     4680

atggtttcta caaagatcgt tatgtttatc ggcactttgc atcggccgcg ctcccgattc     4740

cggaagtgct tgacattggg gaattcagcg agagcctgac ctattgcatc tcccgccgtg     4800

cacagggtgt cacgttgcaa gacctgcctg aaaccgaact gcccgctgtt ctgcagccgg     4860

tcgcggaggc catggatgcg atcgctgcgg ccgatcttag ccagacgagc gggttcggcc     4920

cattcggacc gcaaggaatc ggtcaataca ctacatggcg tgatttcata tgcgcgattg     4980

ctgatcccca tgtgtatcac tggcaaactg tgatggacga caccgtcagt gcgtccgtcg     5040

cgcaggctct cgatgagctg atgctttggg ccgaggactg ccccgaagtc cggcacctcg     5100

tgcacgcgga tttcggctcc aacaatgtcc tgacggacaa tggccgcata acagcggtca     5160

ttgactggag cgaggcgatg ttcggggatt cccaatacga ggtcgccaac atcttcttct     5220

ggaggccgtg gttggcttgt atggagcagc agacgcgcta cttcgagcgg aggcatccgg     5280

agcttgcagg atcgccgcgg ctccgggcgt atatgctccg cattggtctt gaccaactct     5340

atcagagctt ggttgacggc aatttcgatg atgcagcttg ggcgcagggt cgatgcgacg     5400

caatcgtccg atccggagcc gggactgtcg ggcgtacaca aatcgcccgc agaagcgcgg     5460

ccgtctggac cgatggctgt gtagaagtac tcgccgatag tggaaaccga cgccccagca     5520

ctcgtccgag ggcaaaggaa tagcacgtac tacgagattt cgattccacc gccgccttct     5580

atgaaaggtt gggcttcgga atcgttttcc gggacgccgg ctggatgatc ctccagcgcg     5640

gggatctcat gctggagttc ttcgcccacc ccaacttgtt tattgcagct tataatggtt     5700

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     5760

gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctgtataccg tcgacctcta     5820

gctagagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca     5880

caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag     5940

tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt     6000

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc     6060

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg     6120

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa     6180

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg     6240

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga     6300

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg     6360

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg     6420

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc     6480

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg     6540

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca     6600

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt     6660

ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag     6720

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg     6780

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc     6840

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt     6900

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt     6960

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca     7020

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg     7080

tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac     7140

cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg     7200

ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc     7260

gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta     7320

caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac     7380

gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc     7440

ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac     7500

tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact     7560

caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa     7620

tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt     7680

cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca     7740

ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa     7800

aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac     7860

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg     7920

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc     7980

gaaaagtgcc acctgacgtc                                                 8000


<210> 13
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 14
<211> 8561
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg      840

cctggagcaa ttccacaaca cttttgtctt ataccaactt tccgtaccac ttcctaccct      900

cgtaaagtcg acaccggggc ccagatctaa ttgtgagcgc tcacaattcc acaacctaga      960

attgtgagcg ctcacaattc cacaacctag ggatcccgcg ctgttttgac ctccatagaa     1020

gacaccggga ccgatccagc ctccggactc tagcgtttaa acttaagctg ggtacccggg     1080

gatcctctag ggcctctgag ctattccaga agtagtgaag aggctttttt ggaggcctag     1140

gcttttgcaa aaagctccgg atcgatcctg agaacttcag ggtgagtttg gggacccttg     1200

attgttcttt ctttttcgct attgtaaaat tcatgttata tggagggggc aaagttttca     1260

gggtgttgtt tagaatggga agatgtccct tgtatcacca tggaccctca tgataatttt     1320

gtttctttca ctttctactc tgttgacaac cattgtctcc tcttattttc ttttcatttt     1380

ctgtaacttt ttcgttaaac tttagcttgc atttgtaacg aatttttaaa ttcacttttg     1440

tttatttgtc agattgtaag tactttctct aatcactttt ttttcaaggc aatcagggta     1500

tattatattg tacttcagca cagttttaga gaacaattgt tataattaaa tgataaggta     1560

gaatatttct gcatataaat tctggctggc gtggaaatat tcttattggt agaaacaact     1620

acatcctggt catcatcctg cctttctctt tatggttaca atgatataca ctgtttgaga     1680

tgaggataaa atactctgag tccaaaccgg gcccctctgc taaccatgtt catgccttct     1740

tctttttcct acaggtcctg caggcgccac catgaaacca gtaacgttat acgatgtcgc     1800

agagtatgcc ggtgtctctt atcagaccgt ttcccgcgtg gtgaaccagg ccagccacgt     1860

ttctgcgaaa acgcgggaaa aagtggaagc ggcgatggcg gagctgaatt acattcccaa     1920

ccgcgtggca caacaactgg cgggcaaaca gtcgttgctg attggcgttg ccacctccag     1980

tctggccctg cacgcgccgt cgcaaattgt cgcggcgatt aaatctcgcg ccgatcaact     2040

gggtgccagc gtggtggtgt cgatggtaga acgaagcggc gtcgaagcct gtaaagcggc     2100

ggtgcacaat cttctcgcgc aacgcgtcag tgggctgatc attaactatc cgctggatga     2160

ccaggatgcc attgctgtgg aagctgcctg cactaatgtt ccggcgttat ttcttgatgt     2220

ctctgaccag acacccatca acagtattat tttctcccat gaagacggta cgcgactggg     2280

cgtggagcat ctggtcgcat tgggtcacca gcaaatcgcg ctgttagcgg gcccattaag     2340

ttctgtctcg gcgcgtctgc gtctggctgg ctggcataaa tatctcactc gcaatcaaat     2400

tcagccgata gcggaacggg aaggcgactg gagtgccatg tccggttttc aacaaaccat     2460

gcaaatgctg aatgagggca tcgttcccac tgcgatgctg gttgccaacg atcagatggc     2520

gctgggcgca atgcgcgcca ttaccgagtc cgggctgcgc gttggtgcgg atatctcggt     2580

agtgggatac gacgataccg aagacagctc atgttatatc ccgccgttaa ccaccatcaa     2640

acaggatttt cgcctgctgg ggcaaaccag cgtggaccgc ttgctgcaac tctctcaggg     2700

ccaggcggtg aagggcaatc agctgttgcc cgtctcactg gtgaaaagaa aaaccaccct     2760

ggcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc     2820

acgacaggtt tcccgactgg aaagcgggca gccaaaaaag aagagaaagg tcgacggcgg     2880

tggtgctttg tctcctcagc actctgctgt cactcaagga agtatcatca agaacaagga     2940

gggcatggat gctaagtcac taactgcctg gtcccggaca ctggtgacct tcaaggatgt     3000

atttgtggac ttcaccaggg aggagtggaa gctgctggac actgctcagc agatcgtgta     3060

cagaaatgtg atgctggaga actataagaa cctggtttcc ttgggttatc agcttactaa     3120

gccagatgtg atcctccggt tggagaaggg agaagagccc tggctggtgg agagagaaat     3180

tcaccaagag acccatcctg attcagagac tgcatttgaa atcaaatcat cagttggcgg     3240

gccaaaaaag aagagaaagg gtgacggtgc tggtttaatt aacatgggaa gcggagctac     3300

taacttcagc ctgctgaagc aggctggaga cgtggaggag aaccctggac ctgctagcat     3360

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     3420

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     3480

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     3540

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     3600

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     3660

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     3720

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     3780

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     3840

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     3900

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     3960

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     4020

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaggc     4080

ggccgcaatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat     4140

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct     4200

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag     4260

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc     4320

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc     4380

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct     4440

cggctgttgg gcactgacaa ttccgtggtg ttgtcctcga gtctagaggg cccgtttaaa     4500

cccgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc     4560

ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg     4620

aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg     4680

acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta     4740

tggcttctga ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta     4800

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     4860

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     4920

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     4980

acctcgaccc caaaaaactt gattagggtg atggttcacg tacctagaag ttcctattcc     5040

gaagttccta ttctctagaa agtataggaa cttccttggc caaaaagcct gaactcaccg     5100

cgacgtctgt cgagaagttt ctgatcgaaa agttcgacag cgtctccgac ctgatgcagc     5160

tctcggaggg cgaagaatct cgtgctttca gcttcgatgt aggagggcgt ggatatgtcc     5220

tgcgggtaaa tagctgcgcc gatggtttct acaaagatcg ttatgtttat cggcactttg     5280

catcggccgc gctcccgatt ccggaagtgc ttgacattgg ggaattcagc gagagcctga     5340

cctattgcat ctcccgccgt gcacagggtg tcacgttgca agacctgcct gaaaccgaac     5400

tgcccgctgt tctgcagccg gtcgcggagg ccatggatgc gatcgctgcg gccgatctta     5460

gccagacgag cgggttcggc ccattcggac cgcaaggaat cggtcaatac actacatggc     5520

gtgatttcat atgcgcgatt gctgatcccc atgtgtatca ctggcaaact gtgatggacg     5580

acaccgtcag tgcgtccgtc gcgcaggctc tcgatgagct gatgctttgg gccgaggact     5640

gccccgaagt ccggcacctc gtgcacgcgg atttcggctc caacaatgtc ctgacggaca     5700

atggccgcat aacagcggtc attgactgga gcgaggcgat gttcggggat tcccaatacg     5760

aggtcgccaa catcttcttc tggaggccgt ggttggcttg tatggagcag cagacgcgct     5820

acttcgagcg gaggcatccg gagcttgcag gatcgccgcg gctccgggcg tatatgctcc     5880

gcattggtct tgaccaactc tatcagagct tggttgacgg caatttcgat gatgcagctt     5940

gggcgcaggg tcgatgcgac gcaatcgtcc gatccggagc cgggactgtc gggcgtacac     6000

aaatcgcccg cagaagcgcg gccgtctgga ccgatggctg tgtagaagta ctcgccgata     6060

gtggaaaccg acgccccagc actcgtccga gggcaaagga atagcacgta ctacgagatt     6120

tcgattccac cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg     6180

gctggatgat cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt     6240

ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag     6300

catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg     6360

tctgtatacc gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg     6420

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta     6480

aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg     6540

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     6600

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     6660

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     6720

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     6780

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     6840

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     6900

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     6960

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     7020

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     7080

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     7140

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     7200

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     7260

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     7320

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     7380

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     7440

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     7500

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     7560

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     7620

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     7680

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     7740

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     7800

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     7860

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     7920

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     7980

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     8040

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     8100

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     8160

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag     8220

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     8280

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     8340

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     8400

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     8460

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     8520

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt c                         8561


<210> 15
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 16
<211> 8993
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatcg      840

cctggagcaa ttccacaaca cttttgtctt ataccaactt tccgtaccac ttcctaccct      900

cgtaaagtcg acaccggggc ccagatctaa ttgtgagcgc tcacaattcc acaacctaga      960

attgtgagcg ctcacaattc cacaacctag ggatcccgcg ctgttttgac ctccatagaa     1020

gacaccggga ccgatccagc ctccggactc tagcgtttaa acttaagctg ggtacccggg     1080

gatcctctag ggcctctgag ctattccaga agtagtgaag aggctttttt ggaggcctag     1140

gcttttgcaa aaagctccgg atcgatcctg agaacttcag ggtgagtttg gggacccttg     1200

attgttcttt ctttttcgct attgtaaaat tcatgttata tggagggggc aaagttttca     1260

gggtgttgtt tagaatggga agatgtccct tgtatcacca tggaccctca tgataatttt     1320

gtttctttca ctttctactc tgttgacaac cattgtctcc tcttattttc ttttcatttt     1380

ctgtaacttt ttcgttaaac tttagcttgc atttgtaacg aatttttaaa ttcacttttg     1440

tttatttgtc agattgtaag tactttctct aatcactttt ttttcaaggc aatcagggta     1500

tattatattg tacttcagca cagttttaga gaacaattgt tataattaaa tgataaggta     1560

gaatatttct gcatataaat tctggctggc gtggaaatat tcttattggt agaaacaact     1620

acatcctggt catcatcctg cctttctctt tatggttaca atgatataca ctgtttgaga     1680

tgaggataaa atactctgag tccaaaccgg gcccctctgc taaccatgtt catgccttct     1740

tctttttcct acaggtcctg caccgcttga agtctttaat taaaggcgcc accatgaaac     1800

cagtaacgtt atacgatgtc gcagagtatg ccggtgtctc ttatcagacc gtttcccgcg     1860

tggtgaacca ggccagccac gtttctgcga aaacgcggga aaaagtggaa gcggcgatgg     1920

cggagctgaa ttacattccc aaccgcgtgg cacaacaact ggcgggcaaa cagtcgttgc     1980

tgattggcgt tgccacctcc agtctggccc tgcacgcgcc gtcgcaaatt gtcgcggcga     2040

ttaaatctcg cgccgatcaa ctgggtgcca gcgtggtggt gtcgatggta gaacgaagcg     2100

gcgtcgaagc ctgtaaagcg gcggtgcaca atcttctcgc gcaacgcgtc agtgggctga     2160

tcattaacta tccgctggat gaccaggatg ccattgctgt ggaagctgcc tgcactaatg     2220

ttccggcgtt atttcttgat gtctctgacc agacacccat caacagtatt attttctccc     2280

atgaagacgg tacgcgactg ggcgtggagc atctggtcgc attgggtcac cagcaaatcg     2340

cgctgttagc gggcccatta agttctgtct cggcgcgtct gcgtctggct ggctggcata     2400

aatatctcac tcgcaatcaa attcagccga tagcggaacg ggaaggcgac tggagtgcca     2460

tgtccggttt tcaacaaacc atgcaaatgc tgaatgaggg catcgttccc actgcgatgc     2520

tggttgccaa cgatcagatg gcgctgggcg caatgcgcgc cattaccgag tccgggctgc     2580

gcgttggtgc ggatatctcg gtagtgggat acgacgatac cgaagacagc tcatgttata     2640

tcccgccgtt aaccaccatc aaacaggatt ttcgcctgct ggggcaaacc agcgtggacc     2700

gcttgctgca actctctcag ggccaggcgg tgaagggcaa tcagctgttg cccgtctcac     2760

tggtgaaaag aaaaaccacc ctggcgccca atacgcaaac cgcctctccc cgcgcgttgg     2820

ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagccaaaaa     2880

agaagagaaa ggtcgacggc ggtggtgctt tgtctcctca gcactctgct gtcactcaag     2940

gaagtatcat caagaacaag gagggcatgg atgctaagtc actaactgcc tggtcccgga     3000

cactggtgac cttcaaggat gtatttgtgg acttcaccag ggaggagtgg aagctgctgg     3060

acactgctca gcagatcgtg tacagaaatg tgatgctgga gaactataag aacctggttt     3120

ccttgggtta tcagcttact aagccagatg tgatcctccg gttggagaag ggagaagagc     3180

cctggctggt ggagagagaa attcaccaag agacccatcc tgattcagag actgcatttg     3240

aaatcaaatc atcagttggc gggccaaaaa agaagagaaa gggtgacggt gctggtttaa     3300

ttaacatggg aagcggagct actaacttca gcctgctgaa gcaggctgga gacgtggagg     3360

agaaccctgg acctgctagc atggtgagca agggcgagga gctgttcacc ggggtggtgc     3420

ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg     3480

gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc     3540

tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc     3600

gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg     3660

tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga     3720

agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg     3780

acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca     3840

tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg     3900

acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg     3960

tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg     4020

agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca     4080

tggacgagct gtacaagtag aagcttccgc ttgaagtctt taattaaaga gcttgtgagt     4140

atgtgctcgc ttcggcagca catatactat gtcgaatgag gcttcagtac tttacagaat     4200

cgttgcctgc acatcttgga aacacttgct gggattactt cttcaggtta acccaacaga     4260

aggctcgagt gctgttgaca gtgagcgccg cttgaagtct ttaattaaat agtgaagcca     4320

cagatgtatt taattaaaga cttcaagcgg tgcctactgc ctcggagaat tcaaggggct     4380

actttaggag caattatctt gtttactaaa actgaatacc ttgctatctc tttgatacat     4440

ttttacaaag ctgaattaaa atggtataaa ttaaatcact tttttcaatt gtttcctttt     4500

ttttcctcag gcggccgcaa tcaacctctg gattacaaaa tttgtgaaag attgactggt     4560

attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat     4620

catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg     4680

tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt     4740

gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact     4800

ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc     4860

tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcctc gagtctagag     4920

ggcccgttta aacccgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg     4980

tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct     5040

aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg     5100

gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg     5160

cggtgggctc tatggcttct gaggcggaaa gaaccagctg gggctctagg gggtatcccc     5220

acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg     5280

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca     5340

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta     5400

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtacctaga     5460

agttcctatt ccgaagttcc tattctctag aaagtatagg aacttccttg gccaaaaagc     5520

ctgaactcac cgcgacgtct gtcgagaagt ttctgatcga aaagttcgac agcgtctccg     5580

acctgatgca gctctcggag ggcgaagaat ctcgtgcttt cagcttcgat gtaggagggc     5640

gtggatatgt cctgcgggta aatagctgcg ccgatggttt ctacaaagat cgttatgttt     5700

atcggcactt tgcatcggcc gcgctcccga ttccggaagt gcttgacatt ggggaattca     5760

gcgagagcct gacctattgc atctcccgcc gtgcacaggg tgtcacgttg caagacctgc     5820

ctgaaaccga actgcccgct gttctgcagc cggtcgcgga ggccatggat gcgatcgctg     5880

cggccgatct tagccagacg agcgggttcg gcccattcgg accgcaagga atcggtcaat     5940

acactacatg gcgtgatttc atatgcgcga ttgctgatcc ccatgtgtat cactggcaaa     6000

ctgtgatgga cgacaccgtc agtgcgtccg tcgcgcaggc tctcgatgag ctgatgcttt     6060

gggccgagga ctgccccgaa gtccggcacc tcgtgcacgc ggatttcggc tccaacaatg     6120

tcctgacgga caatggccgc ataacagcgg tcattgactg gagcgaggcg atgttcgggg     6180

attcccaata cgaggtcgcc aacatcttct tctggaggcc gtggttggct tgtatggagc     6240

agcagacgcg ctacttcgag cggaggcatc cggagcttgc aggatcgccg cggctccggg     6300

cgtatatgct ccgcattggt cttgaccaac tctatcagag cttggttgac ggcaatttcg     6360

atgatgcagc ttgggcgcag ggtcgatgcg acgcaatcgt ccgatccgga gccgggactg     6420

tcgggcgtac acaaatcgcc cgcagaagcg cggccgtctg gaccgatggc tgtgtagaag     6480

tactcgccga tagtggaaac cgacgcccca gcactcgtcc gagggcaaag gaatagcacg     6540

tactacgaga tttcgattcc accgccgcct tctatgaaag gttgggcttc ggaatcgttt     6600

tccgggacgc cggctggatg atcctccagc gcggggatct catgctggag ttcttcgccc     6660

accccaactt gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt     6720

tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg     6780

tatcttatca tgtctgtata ccgtcgacct ctagctagag cttggcgtaa tcatggtcat     6840

agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata cgagccggaa     6900

gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta attgcgttgc     6960

gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc     7020

aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact     7080

cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac     7140

ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa     7200

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     7260

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     7320

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     7380

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac     7440

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     7500

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     7560

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     7620

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga     7680

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     7740

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     7800

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     7860

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     7920

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     7980

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     8040

tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg     8100

gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag     8160

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     8220

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     8280

ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt     8340

ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca     8400

tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg     8460

ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat     8520

ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta     8580

tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca     8640

gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct     8700

taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat     8760

cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa     8820

agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt     8880

gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa     8940

ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac gtc            8993


