                         SEQUENCE LISTING

<110>  Yale University
 
<120>  Methods For Monoclonal Antibody Generation

<130>  047162-7326WO1(01667)

<150>  63/187,081
<151>  2021-05-11

<150>  63/319,905
<151>  2022-03-15

<160>  290   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 2 HCDR1

<400>  1

Gly Tyr Ser Phe Thr Gly Tyr Ser 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 2 HCDR2

<400>  2

Ile Asn Pro Ser Thr Gly Gly Thr 
1               5               


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 2 HCDR3

<400>  3

Ala Arg Ser Arg Gly Asp Tyr 
1               5           


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 2 LCDR1

<400>  4

Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
1               5                   10  


<210>  5

<400>  5
000

<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 2 LCDR3

<400>  6

Gln Gln Ser Arg Lys Val Pro Trp Thr 
1               5                   


<210>  7
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 2 Heavy Chain Variable Region

<400>  7

Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Ser Met Asn Trp Met Lys Gln Ser Pro Glu Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Ser 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  8
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 2 Light Chain Variable Region

<400>  8

Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Val Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg 
    130         


<210>  9
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 2 Heavy Chain

<400>  9

Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Ser Met Asn Trp Met Lys Gln Ser Pro Glu Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Ser 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  10
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 2 Light Chain

<400>  10

Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Val Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 6 HCDR1

<400>  11

Gly Tyr Thr Phe Thr Ser Tyr Thr 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 6 HCDR2

<400>  12

Ile Asn Pro Thr Ser Gly Tyr Thr 
1               5               


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 6 HCDR3

<400>  13

Ala Arg Glu Gly His Arg Val Gly Pro Ala Tyr 
1               5                   10      


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 6 LCDR1

<400>  14

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  15

<400>  15
000

<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 6 LCDR3

<400>  16

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  17
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 6 Heavy Chain Variable Region

<400>  17

Met Glu Arg His Trp Ile Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Ala Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Thr Ser Gly Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Asp Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly His Arg Val Gly Pro Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  18
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 6 Light Chain Variable Region

<400>  18

Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Thr Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ser Ser Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg 
    130         


<210>  19
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 6 Heavy Chain

<400>  19

Met Glu Arg His Trp Ile Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Ala Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Thr Ser Gly Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Asp Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly His Arg Val Gly Pro Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  20
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 6 Light Chain

<400>  20

Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Thr Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ser Ser Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 12 HCDR1

<400>  21

Gly Tyr Ser Phe Thr Gly Tyr Ser 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 12 HCDR2

<400>  22

Ile Asn Pro Ser Thr Gly Gly Thr 
1               5               


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 12 HCDR3

<400>  23

Ala Arg Ser Arg Gly Asp Tyr 
1               5           


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 12 LCDR1

<400>  24

Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
1               5                   10  


<210>  25

<400>  25
000

<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 12 LCDR3

<400>  26

Gln Gln Ser Arg Lys Val Pro Trp Thr 
1               5                   


<210>  27
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 12 Heavy Chain Variable Region

<400>  27

Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Ser Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Ala Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  28
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 12 Light Chain Variable Region

<400>  28

Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg 
    130         


<210>  29
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 12 Heavy Chain

<400>  29

Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Ser Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Ala Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  30
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 12 Light Chain

<400>  30

Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 13 HCDR1

<400>  31

Gly Tyr Ser Phe Thr Gly Tyr Ser 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 13 HCDR2

<400>  32

Ile Asn Pro Ser Thr Gly Gly Thr 
1               5               


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 13 HCDR3

<400>  33

Ala Arg Ser Arg Gly Asp Tyr 
1               5           


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 13 LCDR1

<400>  34

Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
1               5                   10  


<210>  35

<400>  35
000

<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 13 LCDR3

<400>  36

Gln Gln Ser Arg Lys Val Pro Trp Thr 
1               5                   


<210>  37
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 13 Heavy Chain Variable Region

<400>  37

Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Gly Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  38
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 13 Light Chain Variable Region

<400>  38

Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg 
    130         


<210>  39
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 13 Heavy Chain

<400>  39

Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Gly Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  40
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 13 Light Chain

<400>  40

Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 H1CDR1

<400>  41

Gly Tyr Thr Phe Thr Ser Tyr Thr 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 H1CDR2

<400>  42

Ile Asn Pro Thr Ser Gly Tyr Thr 
1               5               


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 H1CDR3

<400>  43

Ala Arg Glu Gly His Arg Val Gly Pro Ala Tyr 
1               5                   10      


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 H2CDR1

<400>  44

Gly Tyr Ser Phe Thr Gly Tyr Ser 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 H2CDR2

<400>  45

Ile Asn Pro Ser Thr Gly Gly Thr 
1               5               


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 H2CDR3

<400>  46

Ala Arg Ser Arg Gly Asp Tyr 
1               5           


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 L1CDR1

<400>  47

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  48

<400>  48
000

<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 L1CDR3

<400>  49

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 L2CDR1

<400>  50

Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
1               5                   10  


<210>  51

<400>  51
000

<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 L2CDR3

<400>  52

Gln Gln Ser Arg Lys Val Pro Trp Thr 
1               5                   


<210>  53
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 Heavy Chain (H1) Variable Region

<400>  53

Met Glu Arg His Trp Ile Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Ala Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Thr Ser Gly Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Asp Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly His Arg Val Gly Pro Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  54
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 Heavy Chain (H2) Variable Region

<400>  54

Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Ser Met Asn Trp Met Lys Gln Ser Pro Glu Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Ser 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  55
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 Light Chain (L1) Variable Region

<400>  55

Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Thr Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ser Ser Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg 
    130         


<210>  56
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 Light Chain (L2) Variable Region

<400>  56

Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Val Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg 
    130         


<210>  57
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 Heavy Chain (H1)

<400>  57

Met Glu Arg His Trp Ile Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Ala Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Thr Ser Gly Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Asp Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly His Arg Val Gly Pro Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  58
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 Heavy Chain (H2)

<400>  58

Met Gly Trp Asn Trp Ile Phe Ile Leu Ile Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Ser Met Asn Trp Met Lys Gln Ser Pro Glu Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Ser 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  59
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 Light Chain (L1)

<400>  59

Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Thr Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ser Ser Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  60
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone 16 Light Chain (L2)

<400>  60

Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Val Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Arg Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235         


<210>  61
<211>  991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPR23

<400>  61
cgaattcgat atctcgagtg ctagcgtggc tgcaccatct gtcttcatct tcccgccatc       60

tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc      120

cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga      180

gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct      240

gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct      300

gagctcgccc gtcacaaaga gcttcaacag gggagagtgt gacaaaactc acacatgccc      360

accgtgccca gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc      420

caaggacacc ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag      480

ccacgaagac cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc      540

caagacaaag ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac      600

cgtcctgcac caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc      660

cctcccagcc cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca      720

ggtgtgcacc ctgcccccat cccgggacga gctgaccaag aaccaggtca gcctgtcctg      780

cgcggtcaaa ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc      840

ggagaacaac tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcgt      900

cagcaagctc accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt      960

gatgcatgag gctctgcaca accactacac g                                     991


<210>  62
<211>  983
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPR24

<400>  62
gtcacgaatt cgatatctcg agtgctagca ccaagggccc atcggtcttc cccctggcac       60

cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc aaggactact      120

tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc gtgcacacct      180

tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg accgtgccct      240

ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc agcaacacca      300

aggtggacaa gaaagttgag cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc      360

cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca      420

ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg agccacgaag      480

accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat gccaagacaa      540

agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc accgtcctgc      600

accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa gccctcccag      660

cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca caggtgtaca      720

ccctgccacc atgccgggac gagctgacca agaaccaggt cagcctgtgg tgcctggtca      780

aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca      840

actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc tacagcaagc      900

tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg      960

aggctctgca caaccactac acg                                              983


<210>  63
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oPR81-F primer

<400>  63
cttgtcacga attcaccggt caccatggaa atcaaatcga gtgctagcac caagggccca       60

tcggt                                                                   65


<210>  64
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oPR82-R primer

<400>  64
catcaatgta tcttatcatg tcgagcttgc tccctctaac aagatttggg ctcaacttt        59


<210>  65
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 1-VH-gBlcok

<400>  65
cactaagtct tgcacttgtc acgaattcga tggaatggcc cctgatattt cttttcttgc       60

tcagtggaac tgccggcgtg caaagccagg tacaacttca gcaatctggt gcagagctgg      120

ttagaccagg agcaagtgtg aagatttcct gtaaggcatc tgggtacgcc ttctccacct      180

attggatgaa ctgggtcaaa caacggcccg gtaagggtct ggagtggata ggccaaaacc      240

atccaggcga tggagaaact aactacaatg gaaaatttaa agggaaggcc acactgacag      300

ccgataaatc atcctcaacc gcatacatgc agctttcctc actcacttca gaggactccg      360

ctgtctactt ctgcgctcgg tcccccgatt ggggacaagg gacactcgtg acagtctctg      420

ctgctagcac caagggccca tcggtcttcc                                       450


<210>  66
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 2-VH-gBlcok

<400>  66
cactaagtct tgcacttgtc acgaattcga tgggatggaa ctggattttc atcctcattc       60

ttagtgttac tacaggcgtt cactcagaag tccagcttca acagagcggc ccagagcttg      120

taaaaccagg cgcttccgtc aaaatttcct gcaaagcaag cggttatagc ttcactggat      180

atagtatgaa ttggatgaaa cagtcacctg agaagtcatt ggaatggata ggagagatca      240

atcctagtac aggaggtaca actgataacc aaaagtttaa agcaaaggct accttgactg      300

tagacaaatc ttcatcaact gcctatatgc aacttaaaag tttgacttca gaagacagtg      360

ccgtttacta ttgcgctagg tcacgcggag attattgggg acaggggacc tccgtcaccg      420

tgtcttccgc tagcaccaag ggcccatcgg tcttcc                                456


<210>  67
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 3-VH-gBlcok

<400>  67
cactaagtct tgcacttgtc acgaattcga tgggttggtc ttggattttt ctcctgttcc       60

ttagcggtac tgccggcgtc ctttctgaag tccagctcca acagtcaggc cctgaactgg      120

ttaagccagg agcatccgtc aaaataccat gtaaggcatc cggttacact ttcaccgatt      180

acaacatgga ctgggtaaag cagtcccacg ggaagagtct ggagtggatc ggagatataa      240

atccaaacaa tggaggcaca atctataatc agaaatttaa agggaaggca actctgaccg      300

tagacaagtc tagctccaca gcatatatgg agttgcggtc tctgacaagc gaggataccg      360

ccgtctatta ctgcgcaagg tcaaggaacg atttcttcga ttattgggga caagggacta      420

ctttgaccgt ttcttctgct agcaccaagg gcccatcggt cttcc                      465


<210>  68
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 4-VH-gBlcok

<400>  68
cactaagtct tgcacttgtc acgaattcga tggacttcgg tctcatcttc tttatcgtcg       60

cactcctcaa gggcgtccaa tgcgaggtta agctgctgca atctggtgga ggtcttgtac      120

agcctggcgg cagcctgaaa ctttcttgtg ctgcaagtgg gatcgacttc agtagatatt      180

ggatgacctg ggttcggaga gcacctggaa aagggttgga gtggattggc gagataaatc      240

ccgatagctc cactatcgac tatgctcctt cattgaaaga caagtttatc atctctcggg      300

acaacgctaa gaatactctg tatttgcaaa tgtcaaaagt caggagcgaa gatactgctc      360

tgtattactg cgctatcggt gcttactggg gacaggggac attggtcacc gtatccgccg      420

ctagcaccaa gggcccatcg gtcttcc                                          447


<210>  69
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 5-VH-gBlcok

<400>  69
cactaagtct tgcacttgtc acgaattcga tggacttcgg cctgatcttc ttcatcgtgg       60

ccctgctgaa gggcgtgcag tgcgaggtga agctgctgga gagcggcggc ggcctggtgc      120

agcccggcgg cagcctgaag ctgagctgcg ccgccagcgg cttcgacttc agcaggtact      180

ggatgagctg ggtgaggcag gcccccggca agggcctgga gtggatcggc gagatcaacc      240

ccgacagcag caccatcaac tacaccccca gcctgaagga caagttcatc atcagcaggg      300

acaacgccaa gaacaccctg tacctgcaga tgagcaaggt gaggagcgag gacaccgccc      360

tgtactactg cgccaggcag ggctacggca actacttcga ctactggggc cagggcacca      420

ccctgaccgt gagcagcgct agcaccaagg gcccatcggt cttcc                      465


<210>  70
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 6-VH-gBlcok

<400>  70
cactaagtct tgcacttgtc acgaattcga tggagcgaca ttggatcttt ctcttccttc       60

tcagtgtgac agctggggtt cactcccagg tacagctcca acagtcagcc gcagaactcg      120

ctcgccccgg tgcctcagtt aagatgtcct gtaaagcctc agggtatacc tttacatctt      180

atactatgca ttgggtgaaa cagaggcccg gtcaaggact ggagtggatc ggatacataa      240

atcccacatc aggatacact gagtataatc aaaactttaa ggacaaaact actttgaccg      300

ccgacaaatc ttctagtacc gcctatatgc agcttaatag tttgacatcc gaggacagcg      360

ccgtctatta ttgtgctcgg gaggggcacc gagtcgggcc tgcatattgg ggccaaggga      420

ctcttgttac tgtgagcgcc gctagcacca agggcccatc ggtcttcc                   468


<210>  71
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone7-VH-gBlcok

<400>  71
cactaagtct tgcacttgtc acgaattcga tgggctggtc ttggatcttt ctgtttctcc       60

tgtcaggtac cgctggcgta ctctcagagg tccagcttca acagtccggc cctgagcttg      120

taaagcctgg tgccagtgtc aaaataagct gcaagacaag tgggtacact tttactaagt      180

acaccatgca ttgggtgaag cagagccacg gcaaatctct ggaatggata ggcggtatca      240

atcctaacaa tggaggtact agctacaacc aaaaattcaa ggggaaagcc accttgaccg      300

tcgataaatc tagctctact gcttacatgg agttgcgctc actgactagt gaggactccg      360

ctgtgtacta ctgtgctagg accgactatt gggggcaggg tacaactttg actgtatcaa      420

gcgctagcac caagggccca tcggtcttcc                                       450


<210>  72
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 8-VH-gBlcok

<400>  72
cactaagtct tgcacttgtc acgaattcga tggcctgggt gtggaccctg ctgttcctga       60

tggccgccgc ccagagcatc caggcccaga tccagctggt gcagagcggc cccgagctga      120

agaagcccgg cgagaccgtg aagatcagct gcaaggccag cggctacacc ttcaccgact      180

acagcatgca ctgggtgaag caggcccccg gcaagggcct gaagtggatg ggctggatca      240

acaccgagac cggcgagccc acctacgccg acgacttcaa gggcaggttc gccttcagcc      300

tggagaccag cgccagcacc gcctacctgc agatcaacaa cctgaagaac gaggacaccg      360

ccacctactt ctgcgccagg cccggcaggg actactgggg ccagggcacc accctgaccg      420

tgagcagcgc tagcaccaag ggcccatcgg tcttcc                                456


<210>  73
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 9-VH-gBlcok

<400>  73
cactaagtct tgcacttgtc acgaattcga tggagtggac ctgggtgttc ctgttcctgc       60

tgagcgtgac cgccggcgtg cacagccagg tgcaggtgca gcagagcggc gccgagctga      120

tgaagcccgg cgccagcgcc aagatcagct gcaaggccac cggctacacc ttcagcaact      180

actggatcga gtgggtgaag cagaggcccg gccacggcct ggagtggatc ggcgagatcc      240

tgcccggcag cggcgacacc acctacaacg agaggttcaa gggcaaggcc accttcaccg      300

ccgacaccag cagcaacacc gcctacatcc agctgagcag cctgaccagc gaggacagcg      360

ccgtgtacta ctgcgccggc ggcccctacg gcaggttcgc ctactggggc cagggcaccc      420

tggtgaccgt gagcgccgct agcaccaagg gcccatcggt cttcc                      465


<210>  74
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 10-VH-gBlcok

<400>  74
cactaagtct tgcacttgtc acgaattcga tgggttggat ctggatcttc ctcttcttgc       60

tttcaggaac tgctggggta cactctgagg ttcagttgca gcagagtggg cctgaacttg      120

ttaaaaccgg ggcatctgta aagatcagtt gtactgcttc aggatactcc ttctcagggt      180

tcaacatgca ctgggtgaag caaagccatg gaaaaagtct cgagtggatt ggttatagca      240

gttgttacaa tggagctact agttataatc agaagttcaa ggggaaggcc acttttactg      300

tggacacttc cagcagcacc gcctatatgc aatttaattc acttacatcc gaggattctg      360

ccgtctacta ttgcgcccgg agttatggta atagtgccat ggattattgg ggtcaaggaa      420

catcagtaac cgtttcaagc gctagcacca agggcccatc ggtcttcc                   468


<210>  75
<211>  528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 11-VH-gBlcok

<400>  75
cactaagtct tgcacttgtc acgaattcgc actaagtctt gcacttgtca cgaattcgat       60

gaacttcggc ctgagcctga tcttcctggt gctggtgctg aagggcgtgc agtgcgaggt      120

gatgctggtg gagagcggcg gcggcctggt gaagcccggc ggcagcctga agctgagctg      180

cgccgccagc ggcttcacct tcagcagcta cgccatgagc tgggtgaggc agacccccga      240

gaagaggctg gagtgggtgg ccaccatcag cagcggcagc agctacacct acttccccga      300

caccatcatg ggcaggttca ccatcagcag ggacaacgcc aagaacaccc tgtacctgca      360

gatgagcagc ctgaggagcg aggacaccgc catgtactac tgcgccagga ggctggacga      420

cgacggctac ttcgactact ggggccaggg caccaccctg accgtgagca gcgctagcac      480

caagggccca tcggtcttcc gctagcacca agggcccatc ggtcttcc                   528


<210>  76
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 12-VH-gBlcok

<400>  76
cactaagtct tgcacttgtc acgaattcga tgggctggaa ttggatattc attctcatcc       60

ttagcgtcac aacaggggtt catagcgaag tccaacttgt tcagtcaggt gcagaggtga      120

aaaaaccagg cgagtctctt aagatttcct gtaagggatc tggatatagc ttcacggggt      180

acagtatgaa ttggataaga cagccaccgg gtaaaggact ggagtggatt ggagaaataa      240

atccttccac tggtggcact acagacaacc aaaaatttaa ggcccgagtc acgataacgg      300

ctgacgaatc aacaagtacg gcctacatgg aacttagcag ccttcgctct gaagataccg      360

ccgtttacta ctgcgccaga agtagagggg actattgggg ccagggcact ttggtcacgg      420

tgtcctccgc tagcaccaag ggcccatcgg tcttcc                                456


<210>  77
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 13-VH-gBlcok

<400>  77
cactaagtct tgcacttgtc acgaattcga tgggctggaa ctggatattc atccttatcc       60

tttcagtcac tactggagtt cactccgagg ttcagcttgt agaatcaggg ggtgggctgg      120

tccagcctgg gggatctttg cgactgagtt gtgctgcttc aggtttcaca tttagtggct      180

acagcatgaa ctgggttcgg caagcgccag gcaaagggct tgaatgggtg gcggagatca      240

atccatccac aggaggcacg accgataacc agaaatttaa ggcgaggttt accataagta      300

gagataactc taaaaacacg ctctatctcc aaatgaacag tctgcgggcg gaggatactg      360

cagtctacta ttgcgcccgc agccgagggg actattgggg gcagggcact ttggttacag      420

tgtccagcgc tagcaccaag ggcccatcgg tcttcc                                456


<210>  78
<211>  446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 1-VK-gBlcok

<400>  78
cactaagtct tgcacttgtc acgaattcaa tggatatgcg gacacccgct caatttctcg       60

ggattctcct cctttggttt cctggcatca aatgcgatat taagatgaca caaagtcctt      120

cttctatgta cgccagcctc ggcgaacggg tcaccataac ttgtaaggca tcacaggaca      180

taaactcata ccttagttgg ttccaacaga agccaggcaa aagtcctaag actctgatat      240

atcgcgctaa tcgattggtg gatggggtgc cctctcgctt ttccggcagt ggctccgggc      300

aagactactc tctcacaatc agcagcttgg agtatgaaga catgggaata tactactgcc      360

tccagtatga tgaatttcct tggacatttg gaggcgggac taaattggag ataaagcgta      420

cggtggctgc accatctgtc ttcatc                                           446


<210>  79
<211>  452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 2-VK-gBlcok

<400>  79
cactaagtct tgcacttgtc acgaattcaa tggaatcaga tacactcctc ctctgggtgc       60

ttcttttgtg ggtgcctggg tccaccgggg acattgtcct tacccagtca cccgcctcct      120

tggcagtcag tctgggacaa agagccacta taagttgtcg ggcctctgaa tcagttgaat      180

actacggcac ctctcttatg caatggtatc agcaaaagcc cggacagcct cctaaggtac      240

tcatttacgc cgcaagtaat gtagaaagtg gagtgcctgc caggttctct ggcagcggaa      300

gcggtacaga tttctcactc aacatccatc ctgttgaaga agatgacatt gccatgtatt      360

tctgccagca aagcaggaaa gtgccttgga ctttcggtgg tgggacaaag ctcgaaataa      420

agcgtacggt ggctgcacca tctgtcttca tc                                    452


<210>  80
<211>  437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 3-VK-gBlcok

<400>  80
cactaagtct tgcacttgtc acgaattcaa tgtctgtccc cacacaagtt ctcggcctgc       60

tgctcctttg gctcacagat gcccggtgtg acatacagat gacacaatcc cccgccagtc      120

tctcagcttc cgtaggggag accgtaacca ttacctgccg agcatccgag aatatttact      180

caaacttggc atggtatcag cagaagcaag gaaaaagccc ccaactcctg gtttacgttg      240

ccacaaatct cgcccacggg gtcccctcaa ggttcagcgg tagtggctcc gggacccaat      300

acagcctgaa aataaatagc cttcagtctg aggatttcgg gtcctactat tgccaacatt      360

tctgggggac cccaaccttt ggaagtggga ccaaactcga aatcaagcgt acggtggctg      420

caccatctgt cttcatc                                                     437


<210>  81
<211>  449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 4-VK-gBlcok

<400>  81
cactaagtct tgcacttgtc acgaattcaa tgatgtcacc agctcagttc ctcttcctgt       60

tggtgctctg gattcgagaa actaacggag atgtcgtgat gacccaaacc ccacttactc      120

tctccgtgac tatcggccaa cccgctagta tatcatgtaa gtcatctcaa agtttgttgg      180

attccgacgg caagacatat cttaattggc tgctgcaacg cccaggacag tcccctaaga      240

gactgatcta tctcgtgagt aagctcgata gcggggtccc tgaccgattc actggtagtg      300

gaagcggtac tgattttacc ctgaagattt ctcgggtcga ggctgaggac ctcggtgtat      360

attattgttg gcagggaact cacttcccat acaccttcgg aggcggtaca aagctggaaa      420

taaaacgtac ggtggctgca ccatctgtc                                        449


<210>  82
<211>  440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 5-VK-gBlcok

<400>  82
cactaagtct tgcacttgtc acgaattcaa tggtgttcac cccccacatc ctgggcctgc       60

tgctgttctg gatcagcgcc agcaccggcg acatcctgct gacccagagc cccgccaccc      120

tgagcgtgac ccccggcgag accgtgagcc tgagctgcag ggccagccag agcatctaca      180

agaacctgca ctggtaccag cagaagagcc acaggagccc caggctgctg atcaagtacg      240

ccagcgacag catcagcggc atccccagca ggttcaccgg cagcggcagc ggcaccgact      300

acaccctgag catcaacagc gtgaagcccg aggacgaggg catctactac tgcctgcagg      360

gctacagcac ccccctgacc ttcggcgccg gcaccaagct ggagctgaag aggacggtgg      420

ctgcaccatc tgtcttcatc                                                  440


<210>  83
<211>  452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 6-VK-gBlcok

<400>  83
cactaagtct tgcacttgtc acgaattcaa tggagaaaga taccctcttg ctctgggtac       60

tgctgctctg ggtgcctggg tccaccggcg acattgtgct gacacaatca cctgcctccc      120

tggcagtaag tctgggccaa cgggcaacca tctcttgccg ggctagcgaa agtgtagata      180

attacgggat ctctttcatg aattggtttc aacaaacacc tgggcagcct cccaaactgc      240

tcatctacgg ctcaagtaac caaggtagtg gtgtgcctgc taggttttca ggttccggga      300

gtggcacaga cttcagtctg aacatacacc caatggaaga agacgatact gctatgtatt      360

tctgtcaaca gagtaaggag gtaccatata cattcggagg cggaaccaaa ctcgaaatca      420

agaggacggt ggctgcacca tctgtcttca tc                                    452


<210>  84
<211>  455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 7-VK-gBlcok

<400>  84
cactaagtct tgcacttgtc acgaattcaa tgatgagccc cgcccagttc ctgttcctgc       60

tggtgctgtg gatcagggag accaacggcg acgtggtgat gacccagacc cccctgaccc      120

tgagcgtgac catcggccag cccgccagca tcagctgcaa gagcagccag agcctgctgg      180

acagcgacgg caagacctac ctgaactggc tgctgcagag gcccggccag agccccaaga      240

ggctgatcta cctggtgagc aagctggaca gcggcgtgcc cgacaggttc accggcagcg      300

gcagcggcac cgacttcacc ctgaagatca gcagggtgga ggccgaggac ctgggcgtgt      360

actactgctg gcagggcacc cacttcccct acaccttcgg cggcggcacc aagctggaga      420

tcaagaggac ggtggctgca ccatctgtct tcatc                                 455


<210>  85
<211>  452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 8-VK-gBlcok

<400>  85
cactaagtct tgcacttgtc acgaattcaa tgaagctgcc cgtgaggctg ctggtgctga       60

tgttctggat ccccgccagc agcagcgacg tgctgatgac ccagaccccc ctgagcctgc      120

ccgtgagcct gggcgaccag gccagcatca gctgcaggag cagccagagc atcgtgcaca      180

gcaacggcaa cacctacctg gactggtacc tgcagaagcc cggccagagc cccaagctgc      240

tgatctacaa ggtgagcaac aggttcagcg gcgtgcccga caggttcagc ggcagcggca      300

gcggcaccga cttcaccctg aagatcagca gggtggaggc cgaggacctg ggcgtgtact      360

actgcttcca gggcagccac gtgccctgga ccttcggcgg cggcaccaag ctggagatca      420

agaggacggt ggctgcacca tctgtcttca tc                                    452


<210>  86
<211>  440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 9-VK-gBlcok

<400>  86
cactaagtct tgcacttgtc acgaattcaa tgatgagcag cgcccagttc ctgggcctgc       60

tgctgctgtg cttccagggc accaggtgcg acctgcagat gacccagacc accagcagcc      120

tgagcgccag cctgggcgac agggtgacca tcaactgcag ggccagccag gacatcacca      180

actacctgaa ctggtaccag cagaagcccg acggcaccct gaagctgctg atctactaca      240

ccagcaggct gcccagcggc gtgcccagca ggttcagcgg cagcggcagc ggcaccgact      300

acagcctgac catcagcaac ctggagcagg aggacatcgc cacctacttc tgccagcagg      360

gcaagacctt cccctggacc ttcggcggcg gcaccaagct ggagatcaag aggacggtgg      420

ctgcaccatc tgtcttcatc                                                  440


<210>  87
<211>  440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 10-VK-gBlcok

<400>  87
cactaagtct tgcacttgtc acgaattcaa tggagagcca gatccaggcc ttcgtgttcg       60

tgttcctgtg gctgagcggc gtggacggcg acatcgtgat gacccagagc cacaagttca      120

tgagcaccag cgtgggcgac agggtgagca tcacctgcaa ggccagccag gacgtgagca      180

gcgccgtggc ctggtaccag cagaagcccg gccagagccc caaggtgctg atctactggg      240

ccagcaccag gcacaccggc gtgcccgaca ggttcaccgg cagcggcagc ggcaccgact      300

acaccctgac catcaggagc gtgcaggccg aggacctggc cctgtactac tgccagcagc      360

actacaacac ccccaggacc ttcggcggcg gcaccaagct ggagatcaag aggacggtgg      420

ctgcaccatc tgtcttcatc                                                  440


<210>  88
<211>  437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 11-VK-gBlcok

<400>  88
cactaagtct tgcacttgtc acgaattcaa tgcgcccatc tatacagttt ttgggacttc       60

ttctgttctg gcttcatgga gcacaatgcg atatacaaat gacccagtcc ccctcctccc      120

tcagcgccag tttgggcggc aaagtcactg ttacttgcaa ggcctctcag gacataaaca      180

agtatatcgc ttggtatcaa cacaagcccg gtaagggacc acggcttctg attcactata      240

catcaacact tcaaccaggg attccctcaa gattctccgg cagcggttca gggagggatt      300

actcattcag tatcaacaat ctggaacctg aggatatagc cacatactac tgcttgcaat      360

acgacaattt gtacacattc ggaggtggga ctaagctgga gatgaaacgc acggtggctg      420

caccatctgt cttcatc                                                     437


<210>  89
<211>  452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 12-VK-gBlcok

<400>  89
cactaagtct tgcacttgtc acgaattcaa tggaatctga tacattgctt ctttgggtgc       60

tcttgctgtg ggttccaggc tccactggag atattgttat gacccaaagc cctgatagcc      120

tcgccgtctc cctgggcgag cgggcgacga ttaactgcag ggcatcagag agtgttgaat      180

actatggtac aagtctcatg cagtggtatc agcaaaagcc cggtcagcct ccgaaattgt      240

tgatatacgc agcgtccaac gtggaatccg gggtgccatc acggttctcc ggttccggta      300

gtggtacgga cttcaccttc accatttcct ctctgcagcc cgaggatatt gccacatatt      360

actgtcaaca aagtcggaaa gttccatgga ccttcggggg tgggactaaa gtggagataa      420

agcgaacggt ggctgcacca tctgtcttca tc                                    452


<210>  90
<211>  452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Clone 13-VK-gBlcok

<400>  90
cactaagtct tgcacttgtc acgaattcaa tggagtccga tacccttctc ctgtgggtgc       60

tgttgctttg ggtcccaggc agtacgggag atattcagat gacacaatcc ccctctagcc      120

tgtcagcgtc cgtgggcgac cgagttacga ttacctgccg agcatcagaa tccgtagagt      180

attatggcac gtctcttatg caatggtatc agcagaaacc gggtaaagcg ccaaaactgc      240

tcatctacgc ggcgtctaac gtggagtcag gtgtaccctc cagattttct ggttcaggaa      300

gcgggactga ttttacattg actataagct cactgcaacc ggaagatttc gctacctact      360

attgtcaaca atcacggaag gtcccatgga ccttcgggca gggtactaaa gtcgagatta      420

aaaggacggt ggctgcacca tctgtcttca tc                                    452


<210>  91
<211>  998
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UK variant gBlock1

<400>  91
actataggga gacccaagct ggctagccac catgtttgtg ttcctggtgc tgctgccact       60

ggtgtccagc cagtgtgtga acctgaccac caggacccaa cttcctcctg cctacaccaa      120

ctccttcacc aggggagtct actaccctga caaggtgttc aggtcctctg tgctgcacag      180

cacccaggac ctgttcctgc cattcttcag caatgtgacc tggttccatg ccatctctgg      240

caccaatggc accaagaggt ttgacaaccc tgtgctgcca ttcaatgatg gagtctactt      300

tgccagcaca gagaagagca acatcatcag gggctggatt tttggcacca ccctggacag      360

caagacccag tccctgctga ttgtgaacaa tgccaccaat gtggtgatta aggtgtgtga      420

gttccagttc tgtaatgacc cattcctggg agtctaccac aagaacaaca agtcctggat      480

ggagtctgag ttcagggtct actcctctgc caacaactgt acctttgaat atgtgagcca      540

accattcctg atggacttgg agggcaagca gggcaacttc aagaacctga gggagtttgt      600

gttcaagaac attgatggct acttcaagat ttacagcaaa cacacaccaa tcaacctggt      660

gagggacctg ccacagggct tctctgcctt ggaaccactg gtggacctgc caattggcat      720

caacatcacc aggttccaga ccctgctggc tctgcacagg tcctacctga cacctggaga      780

ctcctcctct ggctggacag caggagcagc agcctactat gtgggctacc tccaaccaag      840

gaccttcctg ctgaaataca atgagaatgg caccatcaca gatgctgtgg actgtgccct      900

ggacccactg tctgagacca agtgtaccct gaaatccttc acagtggaga agggcatcta      960

ccagaccagc aacttcaggg tccaaccaac agagagca                              998


<210>  92
<211>  998
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UK variant gBlock2

<400>  92
gggtccaacc aacagagagc attgtgaggt ttccaaacat caccaacctg tgtccatttg       60

gagaggtgtt caatgccacc aggtttgcct ctgtctatgc ctggaacagg aagaggatta      120

gcaactgtgt ggctgactac tctgtgctct acaactctgc ctccttcagc accttcaagt      180

gttatggagt gagcccaacc aaactgaatg acctgtgttt caccaatgtc tatgctgact      240

cctttgtgat taggggagat gaggtgagac agattgcccc tggacaaaca ggcaagattg      300

ctgactacaa ctacaaactg cctgatgact tcacaggctg tgtgattgcc tggaacagca      360

acaacctgga cagcaaggtg ggaggcaact acaactacct ctacagactg ttcaggaaga      420

gcaacctgaa accatttgag agggacatca gcacagagat ttaccaggct ggcagcacac      480

catgtaatgg agtggagggc ttcaactgtt actttccact ccaatcctat ggcttccaac      540

caacctacgg agtgggctac caaccataca gggtggtggt gctgtccttt gaactgctcc      600

atgcccctgc cacagtgtgt ggaccaaaga agagcaccaa cctggtgaag aacaagtgtg      660

tgaacttcaa cttcaatgga ctgacaggca caggagtgct gacagagagc aacaagaagt      720

tcctgccatt ccaacagttt ggcagggaca ttgacgacac cacagatgct gtgagggacc      780

cacagacctt ggagattctg gacatcacac catgttcctt tggaggagtg tctgtgatta      840

cacctggcac caacaccagc aaccaggtgg ctgtgctcta ccaggatgtg aactgtactg      900

aggtgcctgt ggctatccat gctgaccaac ttacaccaac ctggagggtc tacagcacag      960

gcagcaatgt gttccagacc agggctggct gtctgatt                              998


<210>  93
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UK variant gBlock3

<400>  93
ccagggctgg ctgtctgatt ggagcagagc atgtgaacaa ctcctatgag tgtgacatcc       60

caattggagc aggcatctgt gcctcctacc agacccagac caacagccat aggagggcaa      120

ggtctgtggc aagccagagc atcattgcct acacaatgag tctgggagca gagaactctg      180

tggcttacag caacaacagc attgccatcc caattaactt caccatctct gtgaccacag      240

agattctgcc tgtgagtatg accaagacct ctgtggactg tacaatgtat atctgtggag      300

acagcacaga gtgtagcaac ctgctgctcc aatatggctc cttctgtacc caacttaaca      360

gggctctgac aggcattgct gtggaacagg acaagaacac ccaggaggtg tttgcccagg      420

tgaagcagat ttacaagaca cctccaatca aggactttgg aggcttcaac ttcagccaga      480

ttctgcctga cccaagcaag ccaagcaaga ggtccttcat tgaggacctg ctgttcaaca      540

aggtgaccct ggctgatgct ggcttcatca agcaatatgg agactgtctg ggagacattg      600

ctgccaggga cctgatttgt gcccagaagt tcaatggact gacagtgctg cctccactgc      660

tgacagatga gatgattgcc caatacacct ctgccctgct ggctggcacc atcacctctg      720

gctggacctt tggagcagga gcagccctcc aaatcccatt tgctatgcag atggcttaca      780

ggttcaatgg cattggagtg acccagaatg tgctctatga gaaccagaaa ctgattgcca      840

accagttcaa ctctgccatt ggcaagattc aggactccct gtccagcaca gcctctgccc      900

tgggcaaact ccaagatgtg gtgaaccaga atgcccaggc tctgaacacc ctggtgaagc      960

aac                                                                    963


<210>  94
<211>  998
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UK variant gBlock4

<400>  94
aacaccctgg tgaagcaact ttccagcaac tttggagcca tctcctctgt gctgaatgac       60

atcctggcta gactggacaa ggtggaggct gaggtccaga ttgacagact gattacaggc      120

agactccaat ccctccaaac ctatgtgacc caacaactta tcagggctgc tgagattagg      180

gcatctgcca acctggctgc caccaagatg agtgagtgtg tgctgggaca aagcaagagg      240

gtggacttct gtggcaaggg ctaccacctg atgagttttc cacagtctgc ccctcatgga      300

gtggtgttcc tgcatgtgac ctatgtgcct gcccaggaga agaacttcac cacagcccct      360

gccatctgcc atgatggcaa ggctcacttt ccaagggagg gagtgtttgt gagcaatggc      420

acccactggt ttgtgaccca gaggaacttc tatgaaccac agattatcac cacacataac      480

acctttgtgt ctggcaactg tgatgtggtg attggcattg tgaacaacac agtctatgac      540

ccactccaac ctgaactgga ctccttcaag gaggaactgg acaaatactt caagaaccac      600

accagccctg atgtggacct gggagacatc tctggcatca atgcctctgt ggtgaacatc      660

cagaaggaga ttgacagact gaatgaggtg gctaagaacc tgaatgagtc cctgattgac      720

ctccaagaac tgggcaaata tgaacaatac atcaagtggc catggtacat ctggctgggc      780

ttcattgctg gactgattgc cattgtgatg gtgaccataa tgctgtgttg tatgacctcc      840

tgttgttcct gtctgaaagg ctgttgttcc tgtggctcct gttgtaagtt tgatgaggat      900

gactctgaac ctgtgctgaa aggagtgaaa ctgcactaca cctgaggatc cgagctcggt      960

accaagctta agtttaaacc gctgatcagc ctcgactg                              998


<210>  95
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  South African variant-gBlock1

<400>  95
cactataggg agacccaagc tggctagcca ccatgtttgt gttcctggtg ctgctgccac       60

tggtgtccag ccagtgtgtg aacttcacca ccaggaccca acttcctcct gcctacacca      120

actccttcac caggggagtc tactaccctg acaaggtgtt caggtcctct gtgctgcaca      180

gcacccagga cctgttcctg ccattcttca gcaatgtgac ctggttccat gccatccatg      240

tgtctggcac caatggcacc aagaggtttg ccaaccctgt gctgccattc aatgatggag      300

tctactttgc cagcacagag aagagcaaca tcatcagggg ctggattttt ggcaccaccc      360

tggacagcaa gacccagtcc ctgctgattg tgaacaatgc caccaatgtg gtgattaagg      420

tgtgtgagtt ccagttctgt aatgacccat tcctgggagt ctactaccac aagaacaaca      480

agtcctggat ggagtctgag ttcagggtct actcctctgc caacaactgt acctttgaat      540

atgtgagcca accattcctg atggacttgg agggcaagca gggcaacttc aagaacctga      600

gggagtttgt gttcaagaac attgatggct acttcaagat ttacagcaaa cacacaccaa      660

tcaacctggt gaggggcctg ccacagggct tctctgcctt ggaaccactg gtggacctgc      720

caattggcat caacatcacc aggttccaga ccctgctggc tctgcacatt tcctacctga      780

cacctggaga ctcctcctct ggctggacag caggagcagc agcctactat gtgggctacc      840

tccaaccaag gaccttcctg ctgaaataca atgagaatgg caccatcaca gatgctgtgg      900

actgtgccct ggacccactg tctgagacca agtgtaccct gaaatccttc acagtggaga      960

agggcatcta ccagaccagc aacttcaggg tcc                                   993


<210>  96
<211>  1299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  South African variant-gBlock2

<400>  96
ccagcaactt cagggtccaa ccaacagaga gcattgtgag gtttccaaac atcaccaacc       60

tgtgtccatt tggagaggtg ttcaatgcca ccaggtttgc ctctgtctat gcctggaaca      120

ggaagaggat tagcaactgt gtggctgact actctgtgct ctacaactct gcctccttca      180

gcaccttcaa gtgttatgga gtgagcccaa ccaaactgaa tgacctgtgt ttcaccaatg      240

tctatgctga ctcctttgtg attaggggag atgaggtgag acagattgcc cctggacaaa      300

caggcaacat tgctgactac aactacaaac tgcctgatga cttcacaggc tgtgtgattg      360

cctggaacag caacaacctg gacagcaagg tgggaggcaa ctacaactac ctctacagac      420

tgttcaggaa gagcaacctg aaaccatttg agagggacat cagcacagag atttaccagg      480

ctggcagcac accatgtaat ggagtgaagg gcttcaactg ttactttcca ctccaatcct      540

atggcttcca accaacctac ggagtgggct accaaccata cagggtggtg gtgctgtcct      600

ttgaactgct ccatgcccct gccacagtgt gtggaccaaa gaagagcacc aacctggtga      660

agaacaagtg tgtgaacttc aacttcaatg gactgacagg cacaggagtg ctgacagaga      720

gcaacaagaa gttcctgcca ttccaacagt ttggcaggga cattgctgac accacagatg      780

ctgtgaggga cccacagaca ctggagattc tggacatcac accatgttcc tttggaggag      840

tgtctgtgat tacacctggc accaacacca gcaaccaggt ggctgtgctc taccaggatg      900

tgaactgtac tgaggtgcct gtggctatcc atgctgacca acttacacca acctggaggg      960

tctacagcac aggcagcaat gtgttccaga ccagggctgg ctgtctgatt ggagcagagc     1020

atgtgaacaa ctcctatgag tgtgacatcc caattggagc aggcatctgt gcctcctacc     1080

agacccagac caacagccca aggagggcaa ggtctgtggc aagccagagc atcattgcct     1140

acacaatgag tctgggagtg gagaactctg tggcttacag caacaacagc attgccatcc     1200

caaccaactt caccatctct gtgaccacag agattctgcc tgtgagtatg accaagacct     1260

ctgtggactg tacaatgtat atctgtggag acagcacag                            1299


<210>  97
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  del19R1 primer

<400>  97
cttaagcttg gtaccgagct cggatcctca acaacaggag ccacaggaac aac              53


<210>  98
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  del19F1 primer

<400>  98
gctagactgg acaaggtgga ggc                                               23


<210>  99

<400>  99
000

<210>  100

<400>  100
000

<210>  101
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VH2

<400>  101

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  102
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VH8

<400>  102

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  103
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PB_VH3

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Lys Ala Val Glu Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  104
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VK2

<400>  104

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  105
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VK8

<400>  105

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  106
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PB_VK3

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VH2 CDR1

<400>  107

Gly Phe Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VH2 CDR2

<400>  108

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  109
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VH2 CDR3

<400>  109

Cys Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile Trp 
1               5                   10              


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VH8 CDR1

<400>  110

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VH8 CDR2

<400>  111

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  112
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VH8 CDR3

<400>  112

Cys Ala Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile Trp 
1               5                   10                  


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PB_VH3 CDR1

<400>  113

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PB_VH3 CDR2

<400>  114

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  115
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PB_VH3 CDR3

<400>  115

Cys Ala Lys Asp Lys Ala Val Glu Ala Phe Asp Ile Trp 
1               5                   10              


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VK2 CDR1

<400>  116

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  117

<400>  117
000

<210>  118
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VK2 CDR3

<400>  118

Cys Gln Gln Tyr Gly Ser Ser Pro Pro Thr Phe 
1               5                   10      


<210>  119
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VK8 CDR1

<400>  119

Gln Ser Val Leu Tyr Ser Ser Asn Asn Glu Asn Tyr 
1               5                   10          


<210>  120

<400>  120
000

<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB_VK8 CDR3

<400>  121

Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  122
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PB_VK3 CDR1

<400>  122

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  123

<400>  123
000

<210>  124
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PB_VK3 CDR3

<400>  124

Cys Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe 
1               5                   10      


<210>  125
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB_VH2

<400>  125
gaagttcaac ttgttcaaag cggcgcagag gtaaagaaac ctggagagag tctcaaaatc       60

agttgcaagg gatcaggatt ctcatttact tcctactgga taggttgggt ccgacaaatg      120

cctgggaagg gtctcgaatg gatggggatc atatatcctg gagattcaga cacaagatac      180

tccccatctt tccaggggca ggttactatt agtgcggaca aaagtatctc aacagcgtat      240

ctccagtggt ccagtctcaa ggcgagcgat actgcgatgt attattgtgc gaggggtggt      300

tatgaggacg tgttcgatat ttgggggcag ggcacgatgg tcacggtatc ttcc            354


<210>  126
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB_VH8

<400>  126
caggtccagc tgcaagagtc cgggccgggc ctcgtaaaac cctctgagac actgtccctg       60

acttgcacgg tgtctggtgg ttctatctca tcctactatt ggtcctggat tagacagccc      120

ccagggaagg gccttgagtg gatcgggtac atatattatt cagggagcac taactacaat      180

ccttcactca agtcacgagt gactatatcc gttgacacga gcaaaaacca gttttccctc      240

aaattgagta gcgttacagc agcggataca gcagtctatt actgtgcaag aggtctcacg      300

ggaggggacg ccttcgatat atggggccag ggtacgatgg tgaccgttag ttcc            354


<210>  127
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PB_VH3

<400>  127
gaggttcagc ttgtagagtc cggtggcggt ctcgttcaac ccggcgggag cctgaggctg       60

tcttgcgcgg cttcaggatt cacatttagt tcctacgcca tgtcctgggt cagacaagca      120

ccaggaaaag ggttggagtg ggtgtcagtt atctcaggtt ccggaggctc aaccagttac      180

gccgacagcg tcaaaggtcg gttcacgatc tcccgagaca attcaaagaa taccctttat      240

ctccagatga actctttgag ggcggaggac accgccgtgt actattgtgc taaggacaaa      300

gcagtagagg ctttcgacat ttgggggcag ggaactatgg tcaccgtgtc cagt            354


<210>  128
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB_VK2

<400>  128
gaaatagtat tgacgcagtc cccagggact ctgtccctta gtcccggtgg tcgcgctacg       60

ctgagttgcc gagcctccca atcagtgtca agttcttatc ttgcttggta tcagcaaaag      120

cctggtcagg ccccaaggct tctcatctat ggcgcttcat caagagcgac tggtattcca      180

gaccgcttta gtggttcagg aagtggaacc gactttacgc tcactatctc aagactcgaa      240

cctgaagact ttgcagttta ttactgtcag cagtatggga gcagcccacc tacattcggt      300

caaggcacga aggtcgagat taagaga                                          327


<210>  129
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB_VK8

<400>  129
gacattgtaa tgacacagag ccccgactcc ctggccgtgt ctttgggcga gagagcaacc       60

attaattgta agtctagcca aagtgtcctg tattcatcta acaacgagaa ttatttggcc      120

tggtatcaac agaagcctgg acagccaccg aaacttctta tctattgggc gtcaaccaga      180

gagagcggtg tgccagaccg gtttagcgga tctggttctg gaactgattt tactttgacc      240

atatctagcc tccaggcgga agacgtagcg gtctattact gccaacagta ttattccacc      300

ccgttgacct tcggaggcgg aacaaaggtt gaaatcaaga ga                         342


<210>  130
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PB_VK3

<400>  130
gacattcaga tgacccaatc cccgtcaagt ctttctgcat ctgttggaga ccgagtcaca       60

atcacatgtc aagcaagtca agatataagc aactacctta attggtatca gcagaaaccg      120

gggaaggccc ccaagctgtt gatttatgat gcgtctaatc ttgagacggg agtcccatcc      180

cgattcagcg ggtctgggtc tggcacggat ttcacattta caataagctc ccttcaacca      240

gaggacattg ccacatatta ctgtcagcaa tacgataatt tgccgctgac gtttggaggt      300

gggactaagg ttgagattaa acgg                                             324


<210>  131
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG1 Constant Heavy

<400>  131

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  132
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgGkappa Constant

<400>  132

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  133
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB.02 Heavy

<400>  133

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  134
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB.02 Light

<400>  134

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  135
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB.08 Heavy

<400>  135

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  136
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MB.08 Light

<400>  136

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  137
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PB.03 Heavy

<400>  137

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  138
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PB.03 Light

<400>  138

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  139
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB.02 Heavy

<400>  139
gaagttcaac ttgttcaaag cggcgcagag gtaaagaaac ctggagagag tctcaaaatc       60

agttgcaagg gatcaggatt ctcatttact tcctactgga taggttgggt ccgacaaatg      120

cctgggaagg gtctcgaatg gatggggatc atatatcctg gagattcaga cacaagatac      180

tccccatctt tccaggggca ggttactatt agtgcggaca aaagtatctc aacagcgtat      240

ctccagtggt ccagtctcaa ggcgagcgat actgcgatgt attattgtgc gaggggtggt      300

tatgaggacg tgttcgatat ttgggggcag ggcacgatgg tcacggtatc ttccgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatga                                         1347


<210>  140
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB.02 Light

<400>  140
gaaatagtat tgacgcagtc cccagggact ctgtccctta gtcccggtgg tcgcgctacg       60

ctgagttgcc gagcctccca atcagtgtca agttcttatc ttgcttggta tcagcaaaag      120

cctggtcagg ccccaaggct tctcatctat ggcgcttcat caagagcgac tggtattcca      180

gaccgcttta gtggttcagg aagtggaacc gactttacgc tcactatctc aagactcgaa      240

cctgaagact ttgcagttta ttactgtcag cagtatggga gcagcccacc tacattcggt      300

caaggcacga aggtcgagat taagagaacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttag                   648


<210>  141
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB.08 Heavy

<400>  141
caggtccagc tgcaagagtc cgggccgggc ctcgtaaaac cctctgagac actgtccctg       60

acttgcacgg tgtctggtgg ttctatctca tcctactatt ggtcctggat tagacagccc      120

ccagggaagg gccttgagtg gatcgggtac atatattatt cagggagcac taactacaat      180

ccttcactca agtcacgagt gactatatcc gttgacacga gcaaaaacca gttttccctc      240

aaattgagta gcgttacagc agcggataca gcagtctatt actgtgcaag aggtctcacg      300

ggaggggacg ccttcgatat atggggccag ggtacgatgg tgaccgttag ttccgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatga                                         1347


<210>  142
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB.08 Light

<400>  142
gacattgtaa tgacacagag ccccgactcc ctggccgtgt ctttgggcga gagagcaacc       60

attaattgta agtctagcca aagtgtcctg tattcatcta acaacgagaa ttatttggcc      120

tggtatcaac agaagcctgg acagccaccg aaacttctta tctattgggc gtcaaccaga      180

gagagcggtg tgccagaccg gtttagcgga tctggttctg gaactgattt tactttgacc      240

atatctagcc tccaggcgga agacgtagcg gtctattact gccaacagta ttattccacc      300

ccgttgacct tcggaggcgg aacaaaggtt gaaatcaaga gaacggtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660

tag                                                                    663


<210>  143
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PB.03 Heavy

<400>  143
gaggttcagc ttgtagagtc cggtggcggt ctcgttcaac ccggcgggag cctgaggctg       60

tcttgcgcgg cttcaggatt cacatttagt tcctacgcca tgtcctgggt cagacaagca      120

ccaggaaaag ggttggagtg ggtgtcagtt atctcaggtt ccggaggctc aaccagttac      180

gccgacagcg tcaaaggtcg gttcacgatc tcccgagaca attcaaagaa taccctttat      240

ctccagatga actctttgag ggcggaggac accgccgtgt actattgtgc taaggacaaa      300

gcagtagagg ctttcgacat ttgggggcag ggaactatgg tcaccgtgtc cagtgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatga                                         1347


<210>  144
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PB.03 Light

<400>  144
gacattcaga tgacccaatc cccgtcaagt ctttctgcat ctgttggaga ccgagtcaca       60

atcacatgtc aagcaagtca agatataagc aactacctta attggtatca gcagaaaccg      120

gggaaggccc ccaagctgtt gatttatgat gcgtctaatc ttgagacggg agtcccatcc      180

cgattcagcg ggtctgggtc tggcacggat ttcacattta caataagctc ccttcaacca      240

gaggacattg ccacatatta ctgtcagcaa tacgataatt tgccgctgac gtttggaggt      300

gggactaagg ttgagattaa acggacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  145
<211>  4836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB_VH2 Heavy Chain Vector Sequence

<400>  145
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggaagttca acttgttcaa agcggcgcag      660

aggtaaagaa acctggagag agtctcaaaa tcagttgcaa gggatcagga ttctcattta      720

cttcctactg gataggttgg gtccgacaaa tgcctgggaa gggtctcgaa tggatgggga      780

tcatatatcc tggagattca gacacaagat actccccatc tttccagggg caggttacta      840

ttagtgcgga caaaagtatc tcaacagcgt atctccagtg gtccagtctc aaggcgagcg      900

atactgcgat gtattattgt gcgaggggtg gttatgagga cgtgttcgat atttgggggc      960

agggcacgat ggtcacggta tcttccgcta gcaccaaggg cccatcggtc ttccccctgg     1020

caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg gtcaaggact     1080

acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca     1140

ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg gtgaccgtgc     1200

cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag cccagcaaca     1260

ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca tgcccaccgt     1320

gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg     1380

acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg     1440

aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga     1500

caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc     1560

tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc     1620

cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt     1680

acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg acctgcctgg     1740

tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga     1800

acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca     1860

agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc     1920

atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg ggtaaatgag     1980

tcctagctgg ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat     2040

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     2100

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     2160

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggaatt     2220

aattctaaaa tacagcatag caaaacttta acctccaaat caagcctcta cttgaatcct     2280

tttctgaggg atgaataagg cataggcatc aggggctgtt gccaatgtgc attagctgtt     2340

tgcagcctca ccttctttca tggagtttaa gatatagtgt attttcccaa ggtttgaact     2400

agctcttcat ttctttatgt tttaaatgca ctgacctccc acattccctt tttagtaaaa     2460

tattcagaaa taatttaaat acatcattgc aatgaaaata aatgtttttt attaggcaga     2520

atccagatgc tcaaggccct tcataatatc ccccagttta gtagttggac ttagggaaca     2580

aaggaacctt taatagaaat tggacagcaa gaaagcgagc ttctagctta tcctcagtcc     2640

tgctcctctg ccacaaagtg cacgcagttg ccggccgggt cgcgcagggc gaactcccgc     2700

ccccacggct gctcgccgat ctcggtcatg gccggcccgg aggcgtcccg gaagttcgtg     2760

gacacgacct ccgaccactc ggcgtacagc tcgtccaggc cgcgcaccca cacccaggcc     2820

agggtgttgt ccggcaccac ctggtcctgg accgcgctga tgaacagggt cacgtcgtcc     2880

cggaccacac cggcgaagtc gtcctccacg aagtcccggg agaacccgag ccggtcggtc     2940

cagaactcga ccgctccggc gacgtcgcgc gcggtgagca ccggaacggc actggtcaac     3000

ttggccatga tggctcctcc tgtcaggaga ggaaagagaa gaaggttagt acaattgcta     3060

tagtgagttg tattatacta tgcagatata ctatgccaat gattaattgt caaactaggg     3120

ctgcagggtt catagtgcca cttttcctgc actgccccat ctcctgccca ccctttccca     3180

ggcatagaca gtcagtgact taccaaactc acaggaggga gaaggcagaa gcttgagaca     3240

gacccgcggg accgccgaac tgcgagggga cgtggctagg gcggcttctt ttatggtgcg     3300

ccggccctcg gaggcagggc gctcggggag gcctagcggc caatctgcgg tggcaggagg     3360

cggggccgaa ggccgtgcct gaccaatccg gagcacatag gagtctcagc cccccgcccc     3420

aaagcaaggg gaagtcacgc gcctgtagcg ccagcgtgtt gtgaaatggg ggcttggggg     3480

ggttggggcc ctgactagtc aaaacaaact cccattgacg tcaatggggt ggagacttgg     3540

aaatccccgt gagtcaaacc gctatccacg cccattgatg tactgccaaa accgcatcat     3600

catggtaata gcgatgacta atacgtagat gtactgccaa gtaggaaagt cccataaggt     3660

catgtactgg gcataatgcc aggcgggcca tttaccgtca ttgacgtcaa tagggggcgt     3720

acttggcata tgatacactt gatgtactgc caagtgggca gtttaccgta aatactccac     3780

ccattgacgt caatggaaag tccctattgg cgttactatg ggaacatacg tcattattga     3840

cgtcaatggg cgggggtcgt tgggcggtca gccaggcggg ccatttaccg taagttatgt     3900

aacgcctgca ggttaattaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3960

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     4020

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     4080

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     4140

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     4200

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     4260

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     4320

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4380

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     4440

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4500

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4560

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4620

aactcacgtt aagggatttt ggtcatggct agttaattaa catttaaatc agcggccgca     4680

ataaaatatc tttattttca ttacatctgt gtgttggttt tttgtgtgaa tcgtaactaa     4740

catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag gctgtcccca     4800

gtgcaagtgc aggtgccaga acatttctct atcgaa                               4836


<210>  146
<211>  4178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB_VK2 Light Chain Vector Sequence

<400>  146
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca      600

cttgtcacga attcagaaat agtattgacg cagtccccag ggactctgtc ccttagtccc      660

ggtggtcgcg ctacgctgag ttgccgagcc tcccaatcag tgtcaagttc ttatcttgct      720

tggtatcagc aaaagcctgg tcaggcccca aggcttctca tctatggcgc ttcatcaaga      780

gcgactggta ttccagaccg ctttagtggt tcaggaagtg gaaccgactt tacgctcact      840

atctcaagac tcgaacctga agactttgca gtttattact gtcagcagta tgggagcagc      900

ccacctacat tcggtcaagg cacgaaggtc gagattaaga gaacggtggc tgcaccatct      960

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc     1020

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc     1080

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc     1140

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc     1200

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     1260

tagagggagc tagctcgaca tgataagata cattgatgag tttggacaaa ccacaactag     1320

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtgaa     1380

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac     1440

aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc     1500

aagtaaaacc tctacaaatg tggtatggaa ttaattctaa aatacagcat agcaaaactt     1560

taacctccaa atcaagcctc tacttgaatc cttttctgag ggatgaataa ggcataggca     1620

tcaggggctg ttgccaatgt gcattagctg tttgcagcct caccttcttt catggagttt     1680

aagatatagt gtattttccc aaggtttgaa ctagctcttc atttctttat gttttaaatg     1740

cactgacctc ccacattccc tttttagtaa aatattcaga aataatttaa atacatcatt     1800

gcaatgaaaa taaatgtttt ttattaggca gaatccagat gctcaaggcc cttcataata     1860

tcccccagtt tagtagttgg acttagggaa caaaggaacc tttaatagaa attggacagc     1920

aagaaagcga gcttctagct ttagttcctg gtgtacttga gggggatgag ttcctcaatg     1980

gtggttttga ccagcttgcc attcatctca atgagcacaa agcagtcagg agcatagtca     2040

gagatgagct ctctgcacat gccacagggg ctgaccaccc tgatggatct gtccacctca     2100

tcagagtagg ggtgcctgac agccacaatg gtgtcaaagt ccttctgccc gttgctcaca     2160

gcagacccaa tggcaatggc ttcagcacag acagtgaccc tgccaatgta ggcctcaatg     2220

tggacagcag agatgatctc cccagtcttg gtcctgatgg ccgccccgac atggtgcttg     2280

ttgtcctcat agagcatggt gatcttctca gtggcgacct ccaccagctc cagatcctgc     2340

tgagagatgt tgaaggtctt catgatggct cctcctgtca ggagaggaaa gagaagaagg     2400

ttagtacaat tgctatagtg agttgtatta tactatgctt atgattaatt gtcaaactag     2460

ggctgcaggg ttcatagtgc cacttttcct gcactgcccc atctcctgcc caccctttcc     2520

caggcataga cagtcagtga cttaccaaac tcacaggagg gagaaggcag aagcttgaga     2580

cagacccgcg ggaccgccga actgcgaggg gacgtggcta gggcggcttc ttttatggtg     2640

cgccggccct cggaggcagg gcgctcgggg aggcctagcg gccaatctgc ggtggcagga     2700

ggcggggccg aaggccgtgc ctgaccaatc cggagcacat aggagtctca gccccccgcc     2760

ccaaagcaag gggaagtcac gcgcctgtag cgccagcgtg ttgtgaaatg ggggcttggg     2820

ggggttgggg ccctgactag tcaaaacaaa ctcccattga cgtcaatggg gtggagactt     2880

ggaaatcccc gtgagtcaaa ccgctatcca cgcccattga tgtactgcca aaaccgcatc     2940

atcatggtaa tagcgatgac taatacgtag atgtactgcc aagtaggaaa gtcccataag     3000

gtcatgtact gggcataatg ccaggcgggc catttaccgt cattgacgtc aatagggggc     3060

gtacttggca tatgatacac ttgatgtact gccaagtggg cagtttaccg taaatactcc     3120

acccattgac gtcaatggaa agtccctatt ggcgttacta tgggaacata cgtcattatt     3180

gacgtcaatg ggcgggggtc gttgggcggt cagccaggcg ggccatttac cgtaagttat     3240

gtaacgcctg caggttaatt aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3300

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3360

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3420

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3480

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3540

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3600

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3660

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3720

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta     3780

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3840

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3900

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     3960

aaaactcacg ttaagggatt ttggtcatgg ctagttaatt aacatttaaa tcagcggccg     4020

caataaaata tctttatttt cattacatct gtgtgttggt tttttgtgtg aatcgtaact     4080

aacatacgct ctccatcaaa acaaaacgaa acaaaacaaa ctagcaaaat aggctgtccc     4140

cagtgcaagt gcaggtgcca gaacatttct ctatcgaa                             4178


<210>  147
<211>  4836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB_MH8 Heavy Chain Vector Sequence

<400>  147
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cgcaggtcca gctgcaagag tccgggccgg      660

gcctcgtaaa accctctgag acactgtccc tgacttgcac ggtgtctggt ggttctatct      720

catcctacta ttggtcctgg attagacagc ccccagggaa gggccttgag tggatcgggt      780

acatatatta ttcagggagc actaactaca atccttcact caagtcacga gtgactatat      840

ccgttgacac gagcaaaaac cagttttccc tcaaattgag tagcgttaca gcagcggata      900

cagcagtcta ttactgtgca agaggtctca cgggagggga cgccttcgat atatggggcc      960

agggtacgat ggtgaccgtt agttccgcta gcaccaaggg cccatcggtc ttccccctgg     1020

caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg gtcaaggact     1080

acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca     1140

ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg gtgaccgtgc     1200

cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag cccagcaaca     1260

ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca tgcccaccgt     1320

gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg     1380

acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg     1440

aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga     1500

caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc     1560

tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc     1620

cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt     1680

acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg acctgcctgg     1740

tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga     1800

acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca     1860

agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc     1920

atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg ggtaaatgag     1980

tcctagctgg ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat     2040

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     2100

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     2160

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggaatt     2220

aattctaaaa tacagcatag caaaacttta acctccaaat caagcctcta cttgaatcct     2280

tttctgaggg atgaataagg cataggcatc aggggctgtt gccaatgtgc attagctgtt     2340

tgcagcctca ccttctttca tggagtttaa gatatagtgt attttcccaa ggtttgaact     2400

agctcttcat ttctttatgt tttaaatgca ctgacctccc acattccctt tttagtaaaa     2460

tattcagaaa taatttaaat acatcattgc aatgaaaata aatgtttttt attaggcaga     2520

atccagatgc tcaaggccct tcataatatc ccccagttta gtagttggac ttagggaaca     2580

aaggaacctt taatagaaat tggacagcaa gaaagcgagc ttctagctta tcctcagtcc     2640

tgctcctctg ccacaaagtg cacgcagttg ccggccgggt cgcgcagggc gaactcccgc     2700

ccccacggct gctcgccgat ctcggtcatg gccggcccgg aggcgtcccg gaagttcgtg     2760

gacacgacct ccgaccactc ggcgtacagc tcgtccaggc cgcgcaccca cacccaggcc     2820

agggtgttgt ccggcaccac ctggtcctgg accgcgctga tgaacagggt cacgtcgtcc     2880

cggaccacac cggcgaagtc gtcctccacg aagtcccggg agaacccgag ccggtcggtc     2940

cagaactcga ccgctccggc gacgtcgcgc gcggtgagca ccggaacggc actggtcaac     3000

ttggccatga tggctcctcc tgtcaggaga ggaaagagaa gaaggttagt acaattgcta     3060

tagtgagttg tattatacta tgcagatata ctatgccaat gattaattgt caaactaggg     3120

ctgcagggtt catagtgcca cttttcctgc actgccccat ctcctgccca ccctttccca     3180

ggcatagaca gtcagtgact taccaaactc acaggaggga gaaggcagaa gcttgagaca     3240

gacccgcggg accgccgaac tgcgagggga cgtggctagg gcggcttctt ttatggtgcg     3300

ccggccctcg gaggcagggc gctcggggag gcctagcggc caatctgcgg tggcaggagg     3360

cggggccgaa ggccgtgcct gaccaatccg gagcacatag gagtctcagc cccccgcccc     3420

aaagcaaggg gaagtcacgc gcctgtagcg ccagcgtgtt gtgaaatggg ggcttggggg     3480

ggttggggcc ctgactagtc aaaacaaact cccattgacg tcaatggggt ggagacttgg     3540

aaatccccgt gagtcaaacc gctatccacg cccattgatg tactgccaaa accgcatcat     3600

catggtaata gcgatgacta atacgtagat gtactgccaa gtaggaaagt cccataaggt     3660

catgtactgg gcataatgcc aggcgggcca tttaccgtca ttgacgtcaa tagggggcgt     3720

acttggcata tgatacactt gatgtactgc caagtgggca gtttaccgta aatactccac     3780

ccattgacgt caatggaaag tccctattgg cgttactatg ggaacatacg tcattattga     3840

cgtcaatggg cgggggtcgt tgggcggtca gccaggcggg ccatttaccg taagttatgt     3900

aacgcctgca ggttaattaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3960

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     4020

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     4080

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     4140

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     4200

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     4260

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     4320

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4380

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     4440

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4500

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4560

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4620

aactcacgtt aagggatttt ggtcatggct agttaattaa catttaaatc agcggccgca     4680

ataaaatatc tttattttca ttacatctgt gtgttggttt tttgtgtgaa tcgtaactaa     4740

catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag gctgtcccca     4800

gtgcaagtgc aggtgccaga acatttctct atcgaa                               4836


<210>  148
<211>  4193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MB_VK8 Light Chain Vector Sequence

<400>  148
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca      600

cttgtcacga attcagacat tgtaatgaca cagagccccg actccctggc cgtgtctttg      660

ggcgagagag caaccattaa ttgtaagtct agccaaagtg tcctgtattc atctaacaac      720

gagaattatt tggcctggta tcaacagaag cctggacagc caccgaaact tcttatctat      780

tgggcgtcaa ccagagagag cggtgtgcca gaccggttta gcggatctgg ttctggaact      840

gattttactt tgaccatatc tagcctccag gcggaagacg tagcggtcta ttactgccaa      900

cagtattatt ccaccccgtt gaccttcgga ggcggaacaa aggttgaaat caagagaacg      960

gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact     1020

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     1080

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     1140

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     1200

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     1260

aacaggggag agtgttagag ggagctagct cgacatgata agatacattg atgagtttgg     1320

acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat     1380

tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat     1440

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg     1500

gaggtttttt aaagcaagta aaacctctac aaatgtggta tggaattaat tctaaaatac     1560

agcatagcaa aactttaacc tccaaatcaa gcctctactt gaatcctttt ctgagggatg     1620

aataaggcat aggcatcagg ggctgttgcc aatgtgcatt agctgtttgc agcctcacct     1680

tctttcatgg agtttaagat atagtgtatt ttcccaaggt ttgaactagc tcttcatttc     1740

tttatgtttt aaatgcactg acctcccaca ttcccttttt agtaaaatat tcagaaataa     1800

tttaaataca tcattgcaat gaaaataaat gttttttatt aggcagaatc cagatgctca     1860

aggcccttca taatatcccc cagtttagta gttggactta gggaacaaag gaacctttaa     1920

tagaaattgg acagcaagaa agcgagcttc tagctttagt tcctggtgta cttgaggggg     1980

atgagttcct caatggtggt tttgaccagc ttgccattca tctcaatgag cacaaagcag     2040

tcaggagcat agtcagagat gagctctctg cacatgccac aggggctgac caccctgatg     2100

gatctgtcca cctcatcaga gtaggggtgc ctgacagcca caatggtgtc aaagtccttc     2160

tgcccgttgc tcacagcaga cccaatggca atggcttcag cacagacagt gaccctgcca     2220

atgtaggcct caatgtggac agcagagatg atctccccag tcttggtcct gatggccgcc     2280

ccgacatggt gcttgttgtc ctcatagagc atggtgatct tctcagtggc gacctccacc     2340

agctccagat cctgctgaga gatgttgaag gtcttcatga tggctcctcc tgtcaggaga     2400

ggaaagagaa gaaggttagt acaattgcta tagtgagttg tattatacta tgcttatgat     2460

taattgtcaa actagggctg cagggttcat agtgccactt ttcctgcact gccccatctc     2520

ctgcccaccc tttcccaggc atagacagtc agtgacttac caaactcaca ggagggagaa     2580

ggcagaagct tgagacagac ccgcgggacc gccgaactgc gaggggacgt ggctagggcg     2640

gcttctttta tggtgcgccg gccctcggag gcagggcgct cggggaggcc tagcggccaa     2700

tctgcggtgg caggaggcgg ggccgaaggc cgtgcctgac caatccggag cacataggag     2760

tctcagcccc ccgccccaaa gcaaggggaa gtcacgcgcc tgtagcgcca gcgtgttgtg     2820

aaatgggggc ttgggggggt tggggccctg actagtcaaa acaaactccc attgacgtca     2880

atggggtgga gacttggaaa tccccgtgag tcaaaccgct atccacgccc attgatgtac     2940

tgccaaaacc gcatcatcat ggtaatagcg atgactaata cgtagatgta ctgccaagta     3000

ggaaagtccc ataaggtcat gtactgggca taatgccagg cgggccattt accgtcattg     3060

acgtcaatag ggggcgtact tggcatatga tacacttgat gtactgccaa gtgggcagtt     3120

taccgtaaat actccaccca ttgacgtcaa tggaaagtcc ctattggcgt tactatggga     3180

acatacgtca ttattgacgt caatgggcgg gggtcgttgg gcggtcagcc aggcgggcca     3240

tttaccgtaa gttatgtaac gcctgcaggt taattaagaa catgtgagca aaaggccagc     3300

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     3360

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     3420

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     3480

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     3540

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     3600

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     3660

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     3720

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     3780

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     3840

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc     3900

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg     3960

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catggctagt taattaacat     4020

ttaaatcagc ggccgcaata aaatatcttt attttcatta catctgtgtg ttggtttttt     4080

gtgtgaatcg taactaacat acgctctcca tcaaaacaaa acgaaacaaa acaaactagc     4140

aaaataggct gtccccagtg caagtgcagg tgccagaaca tttctctatc gaa            4193


<210>  149
<211>  4836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PB_VH3 Heavy Chain Vector Sequence

<400>  149
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggaggttca gcttgtagag tccggtggcg      660

gtctcgttca acccggcggg agcctgaggc tgtcttgcgc ggcttcagga ttcacattta      720

gttcctacgc catgtcctgg gtcagacaag caccaggaaa agggttggag tgggtgtcag      780

ttatctcagg ttccggaggc tcaaccagtt acgccgacag cgtcaaaggt cggttcacga      840

tctcccgaga caattcaaag aatacccttt atctccagat gaactctttg agggcggagg      900

acaccgccgt gtactattgt gctaaggaca aagcagtaga ggctttcgac atttgggggc      960

agggaactat ggtcaccgtg tccagtgcta gcaccaaggg cccatcggtc ttccccctgg     1020

caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg gtcaaggact     1080

acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca     1140

ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg gtgaccgtgc     1200

cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag cccagcaaca     1260

ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca tgcccaccgt     1320

gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg     1380

acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg     1440

aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga     1500

caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc     1560

tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc     1620

cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt     1680

acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg acctgcctgg     1740

tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga     1800

acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca     1860

agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc     1920

atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg ggtaaatgag     1980

tcctagctgg ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat     2040

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     2100

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     2160

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggaatt     2220

aattctaaaa tacagcatag caaaacttta acctccaaat caagcctcta cttgaatcct     2280

tttctgaggg atgaataagg cataggcatc aggggctgtt gccaatgtgc attagctgtt     2340

tgcagcctca ccttctttca tggagtttaa gatatagtgt attttcccaa ggtttgaact     2400

agctcttcat ttctttatgt tttaaatgca ctgacctccc acattccctt tttagtaaaa     2460

tattcagaaa taatttaaat acatcattgc aatgaaaata aatgtttttt attaggcaga     2520

atccagatgc tcaaggccct tcataatatc ccccagttta gtagttggac ttagggaaca     2580

aaggaacctt taatagaaat tggacagcaa gaaagcgagc ttctagctta tcctcagtcc     2640

tgctcctctg ccacaaagtg cacgcagttg ccggccgggt cgcgcagggc gaactcccgc     2700

ccccacggct gctcgccgat ctcggtcatg gccggcccgg aggcgtcccg gaagttcgtg     2760

gacacgacct ccgaccactc ggcgtacagc tcgtccaggc cgcgcaccca cacccaggcc     2820

agggtgttgt ccggcaccac ctggtcctgg accgcgctga tgaacagggt cacgtcgtcc     2880

cggaccacac cggcgaagtc gtcctccacg aagtcccggg agaacccgag ccggtcggtc     2940

cagaactcga ccgctccggc gacgtcgcgc gcggtgagca ccggaacggc actggtcaac     3000

ttggccatga tggctcctcc tgtcaggaga ggaaagagaa gaaggttagt acaattgcta     3060

tagtgagttg tattatacta tgcagatata ctatgccaat gattaattgt caaactaggg     3120

ctgcagggtt catagtgcca cttttcctgc actgccccat ctcctgccca ccctttccca     3180

ggcatagaca gtcagtgact taccaaactc acaggaggga gaaggcagaa gcttgagaca     3240

gacccgcggg accgccgaac tgcgagggga cgtggctagg gcggcttctt ttatggtgcg     3300

ccggccctcg gaggcagggc gctcggggag gcctagcggc caatctgcgg tggcaggagg     3360

cggggccgaa ggccgtgcct gaccaatccg gagcacatag gagtctcagc cccccgcccc     3420

aaagcaaggg gaagtcacgc gcctgtagcg ccagcgtgtt gtgaaatggg ggcttggggg     3480

ggttggggcc ctgactagtc aaaacaaact cccattgacg tcaatggggt ggagacttgg     3540

aaatccccgt gagtcaaacc gctatccacg cccattgatg tactgccaaa accgcatcat     3600

catggtaata gcgatgacta atacgtagat gtactgccaa gtaggaaagt cccataaggt     3660

catgtactgg gcataatgcc aggcgggcca tttaccgtca ttgacgtcaa tagggggcgt     3720

acttggcata tgatacactt gatgtactgc caagtgggca gtttaccgta aatactccac     3780

ccattgacgt caatggaaag tccctattgg cgttactatg ggaacatacg tcattattga     3840

cgtcaatggg cgggggtcgt tgggcggtca gccaggcggg ccatttaccg taagttatgt     3900

aacgcctgca ggttaattaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3960

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     4020

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     4080

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     4140

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     4200

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     4260

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     4320

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4380

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     4440

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4500

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4560

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4620

aactcacgtt aagggatttt ggtcatggct agttaattaa catttaaatc agcggccgca     4680

ataaaatatc tttattttca ttacatctgt gtgttggttt tttgtgtgaa tcgtaactaa     4740

catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag gctgtcccca     4800

gtgcaagtgc aggtgccaga acatttctct atcgaa                               4836


<210>  150
<211>  4175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PB_VK3 Light Chain Vector Sequence

<400>  150
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca      600

cttgtcacga attcagacat tcagatgacc caatccccgt caagtctttc tgcatctgtt      660

ggagaccgag tcacaatcac atgtcaagca agtcaagata taagcaacta ccttaattgg      720

tatcagcaga aaccggggaa ggcccccaag ctgttgattt atgatgcgtc taatcttgag      780

acgggagtcc catcccgatt cagcgggtct gggtctggca cggatttcac atttacaata      840

agctcccttc aaccagagga cattgccaca tattactgtc agcaatacga taatttgccg      900

ctgacgtttg gaggtgggac taaggttgag attaaacgga cggtggctgc accatctgtc      960

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     1020

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa     1080

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     1140

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa     1200

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag     1260

agggagctag ctcgacatga taagatacat tgatgagttt ggacaaacca caactagaat     1320

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtgaaatt     1380

tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac     1440

aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag     1500

taaaacctct acaaatgtgg tatggaatta attctaaaat acagcatagc aaaactttaa     1560

cctccaaatc aagcctctac ttgaatcctt ttctgaggga tgaataaggc ataggcatca     1620

ggggctgttg ccaatgtgca ttagctgttt gcagcctcac cttctttcat ggagtttaag     1680

atatagtgta ttttcccaag gtttgaacta gctcttcatt tctttatgtt ttaaatgcac     1740

tgacctccca cattcccttt ttagtaaaat attcagaaat aatttaaata catcattgca     1800

atgaaaataa atgtttttta ttaggcagaa tccagatgct caaggccctt cataatatcc     1860

cccagtttag tagttggact tagggaacaa aggaaccttt aatagaaatt ggacagcaag     1920

aaagcgagct tctagcttta gttcctggtg tacttgaggg ggatgagttc ctcaatggtg     1980

gttttgacca gcttgccatt catctcaatg agcacaaagc agtcaggagc atagtcagag     2040

atgagctctc tgcacatgcc acaggggctg accaccctga tggatctgtc cacctcatca     2100

gagtaggggt gcctgacagc cacaatggtg tcaaagtcct tctgcccgtt gctcacagca     2160

gacccaatgg caatggcttc agcacagaca gtgaccctgc caatgtaggc ctcaatgtgg     2220

acagcagaga tgatctcccc agtcttggtc ctgatggccg ccccgacatg gtgcttgttg     2280

tcctcataga gcatggtgat cttctcagtg gcgacctcca ccagctccag atcctgctga     2340

gagatgttga aggtcttcat gatggctcct cctgtcagga gaggaaagag aagaaggtta     2400

gtacaattgc tatagtgagt tgtattatac tatgcttatg attaattgtc aaactagggc     2460

tgcagggttc atagtgccac ttttcctgca ctgccccatc tcctgcccac cctttcccag     2520

gcatagacag tcagtgactt accaaactca caggagggag aaggcagaag cttgagacag     2580

acccgcggga ccgccgaact gcgaggggac gtggctaggg cggcttcttt tatggtgcgc     2640

cggccctcgg aggcagggcg ctcggggagg cctagcggcc aatctgcggt ggcaggaggc     2700

ggggccgaag gccgtgcctg accaatccgg agcacatagg agtctcagcc ccccgcccca     2760

aagcaagggg aagtcacgcg cctgtagcgc cagcgtgttg tgaaatgggg gcttgggggg     2820

gttggggccc tgactagtca aaacaaactc ccattgacgt caatggggtg gagacttgga     2880

aatccccgtg agtcaaaccg ctatccacgc ccattgatgt actgccaaaa ccgcatcatc     2940

atggtaatag cgatgactaa tacgtagatg tactgccaag taggaaagtc ccataaggtc     3000

atgtactggg cataatgcca ggcgggccat ttaccgtcat tgacgtcaat agggggcgta     3060

cttggcatat gatacacttg atgtactgcc aagtgggcag tttaccgtaa atactccacc     3120

cattgacgtc aatggaaagt ccctattggc gttactatgg gaacatacgt cattattgac     3180

gtcaatgggc gggggtcgtt gggcggtcag ccaggcgggc catttaccgt aagttatgta     3240

acgcctgcag gttaattaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     3300

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     3360

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     3420

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     3480

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     3540

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     3600

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     3660

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     3720

cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct     3780

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     3840

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     3900

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa     3960

actcacgtta agggattttg gtcatggcta gttaattaac atttaaatca gcggccgcaa     4020

taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat cgtaactaac     4080

atacgctctc catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg ctgtccccag     4140

tgcaagtgca ggtgccagaa catttctcta tcgaa                                4175


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-KNOB-1 HCDR1

<400>  151

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-KNOB-1 HCDR2

<400>  152

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  153
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-KNOB-1 HCDR3

<400>  153

Ala Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile 
1               5                   10          


<210>  154
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-KNOB-1 VH

<400>  154

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  155
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-KNOB-1 HEAVY CHAIN

<400>  155

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  156
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-KNOB-1 VH

<400>  156
caggtccagc tgcaagagtc cgggccgggc ctcgtaaaac cctctgagac actgtccctg       60

acttgcacgg tgtctggtgg ttctatctca tcctactatt ggtcctggat tagacagccc      120

ccagggaagg gccttgagtg gatcgggtac atatattatt cagggagcac taactacaat      180

ccttcactca agtcacgagt gactatatcc gttgacacga gcaaaaacca gttttccctc      240

aaattgagta gcgttacagc agcggataca gcagtctatt actgtgcaag aggtctcacg      300

ggaggggacg ccttcgatat atggggccag ggtacgatgg tgaccgttag ttcc            354


<210>  157
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-KNOB-1 HEAVY CHAIN

<400>  157
caggtccagc tgcaagagtc cgggccgggc ctcgtaaaac cctctgagac actgtccctg       60

acttgcacgg tgtctggtgg ttctatctca tcctactatt ggtcctggat tagacagccc      120

ccagggaagg gccttgagtg gatcgggtac atatattatt cagggagcac taactacaat      180

ccttcactca agtcacgagt gactatatcc gttgacacga gcaaaaacca gttttccctc      240

aaattgagta gcgttacagc agcggataca gcagtctatt actgtgcaag aggtctcacg      300

ggaggggacg ccttcgatat atggggccag ggtacgatgg tgaccgttag ttccgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgccac catgccggga cgagctgacc     1080

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatga                                         1347


<210>  158
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-HOLE-2 HCDR1

<400>  158

Gly Phe Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  159
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-HOLE-2 HCDR2

<400>  159

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-HOLE-2 HCDR3

<400>  160

Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile 
1               5                   10      


<210>  161
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-HOLE-2 VH

<400>  161

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  162
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-HOLE-2 HEAVY CHAIN

<400>  162

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
    130                 135                 140                 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
145                 150                 155                 160 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
                165                 170                 175     


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
            180                 185                 190         


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
        195                 200                 205             


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  163
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-HOLE-2 VH

<400>  163
gaagttcaac ttgttcaaag cggcgcagag gtaaagaaac ctggagagag tctcaaaatc       60

agttgcaagg gatcaggatt ctcatttact tcctactgga taggttgggt ccgacaaatg      120

cctgggaagg gtctcgaatg gatggggatc atatatcctg gagattcaga cacaagatac      180

tccccatctt tccaggggca ggttactatt agtgcggaca aaagtatctc aacagcgtat      240

ctccagtggt ccagtctcaa ggcgagcgat actgcgatgt attattgtgc gaggggtggt      300

tatgaggacg tgttcgatat ttgggggcag ggcacgatgg tcacggtatc ttcc            354


<210>  164
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0208 IGG1-HOLE-2 HEAVY CHAIN

<400>  164
gaagttcaac ttgttcaaag cggcgcagag gtaaagaaac ctggagagag tctcaaaatc       60

agttgcaagg gatcaggatt ctcatttact tcctactgga taggttgggt ccgacaaatg      120

cctgggaagg gtctcgaatg gatggggatc atatatcctg gagattcaga cacaagatac      180

tccccatctt tccaggggca ggttactatt agtgcggaca aaagtatctc aacagcgtat      240

ctccagtggt ccagtctcaa ggcgagcgat actgcgatgt attattgtgc gaggggtggt      300

tatgaggacg tgttcgatat ttgggggcag ggcacgatgg tcacggtatc ttccgctagc      360

gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      420

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag      480

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag      540

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac      600

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc      660

aacaggggag agtgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt gcaccctgcc cccatcccgg     1080

gacgagctga ccaagaacca ggtcagcctg tcctgcgcgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctcgtcagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            1359


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-1 LCDR1

<400>  165

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  166
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-1 LCDR3

<400>  166

Cys Gln Gln Tyr Gly Ser Ser Pro Pro Thr Phe 
1               5                   10      


<210>  167
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-1 VL

<400>  167

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  168
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-1

<400>  168

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Val Glu Pro Lys Ser Cys 
    210                 


<210>  169
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-1 VL

<400>  169
gaaatagtat tgacgcagtc cccagggact ctgtccctta gtcccggtgg tcgcgctacg       60

ctgagttgcc gagcctccca atcagtgtca agttcttatc ttgcttggta tcagcaaaag      120

cctggtcagg ccccaaggct tctcatctat ggcgcttcat caagagcgac tggtattcca      180

gaccgcttta gtggttcagg aagtggaacc gactttacgc tcactatctc aagactcgaa      240

cctgaagact ttgcagttta ttactgtcag cagtatggga gcagcccacc tacattcggt      300

caaggcacga aggtcgagat taagaga                                          327


<210>  170
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-1

<400>  170
gaaatagtat tgacgcagtc cccagggact ctgtccctta gtcccggtgg tcgcgctacg       60

ctgagttgcc gagcctccca atcagtgtca agttcttatc ttgcttggta tcagcaaaag      120

cctggtcagg ccccaaggct tctcatctat ggcgcttcat caagagcgac tggtattcca      180

gaccgcttta gtggttcagg aagtggaacc gactttacgc tcactatctc aagactcgaa      240

cctgaagact ttgcagttta ttactgtcag cagtatggga gcagcccacc tacattcggt      300

caaggcacga aggtcgagat taagagatcg agtgctagca ccaagggccc atcggtcttc      360

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc      480

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg      540

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc      600

agcaacacca aggtggacaa gaaagttgag cccaaatctt gttag                      645


<210>  171
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-2 LCDR1

<400>  171

Gln Ser Val Leu Tyr Ser Ser Asn Asn Glu Asn Tyr 
1               5                   10          


<210>  172
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-2 LCDR3

<400>  172

Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  173
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-2 VL

<400>  173

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  174
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-2

<400>  174

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  175
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-2 VL

<400>  175
gacattgtaa tgacacagag ccccgactcc ctggccgtgt ctttgggcga gagagcaacc       60

attaattgta agtctagcca aagtgtcctg tattcatcta acaacgagaa ttatttggcc      120

tggtatcaac agaagcctgg acagccaccg aaacttctta tctattgggc gtcaaccaga      180

gagagcggtg tgccagaccg gtttagcgga tctggttctg gaactgattt tactttgacc      240

atatctagcc tccaggcgga agacgtagcg gtctattact gccaacagta ttattccacc      300

ccgttgacct tcggaggcgg aacaaaggtt gaaatcaaga ga                         342


<210>  176
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0208 LIGHT CHAIN-2

<400>  176
gacattgtaa tgacacagag ccccgactcc ctggccgtgt ctttgggcga gagagcaacc       60

attaattgta agtctagcca aagtgtcctg tattcatcta acaacgagaa ttatttggcc      120

tggtatcaac agaagcctgg acagccaccg aaacttctta tctattgggc gtcaaccaga      180

gagagcggtg tgccagaccg gtttagcgga tctggttctg gaactgattt tactttgacc      240

atatctagcc tccaggcgga agacgtagcg gtctattact gccaacagta ttattccacc      300

ccgttgacct tcggaggcgg aacaaaggtt gaaatcaaga gaacggtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660

tag                                                                    663


<210>  177
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-KNOB-1 HCDR1

<400>  177

Gly Phe Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  178
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-KNOB-1 HCDR2

<400>  178

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  179
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-KNOB-1 HCDR3

<400>  179

Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile 
1               5                   10      


<210>  180
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-KNOB-1 VH

<400>  180

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  181
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-KNOB-1 HEAVY CHAIN

<400>  181

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  182
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-KNOB-1 VH

<400>  182
gaagttcaac ttgttcaaag cggcgcagag gtaaagaaac ctggagagag tctcaaaatc       60

agttgcaagg gatcaggatt ctcatttact tcctactgga taggttgggt ccgacaaatg      120

cctgggaagg gtctcgaatg gatggggatc atatatcctg gagattcaga cacaagatac      180

tccccatctt tccaggggca ggttactatt agtgcggaca aaagtatctc aacagcgtat      240

ctccagtggt ccagtctcaa ggcgagcgat actgcgatgt attattgtgc gaggggtggt      300

tatgaggacg tgttcgatat ttgggggcag ggcacgatgg tcacggtatc ttcc            354


<210>  183
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-KNOB-1 HEAVY CHAIN

<400>  183
gaagttcaac ttgttcaaag cggcgcagag gtaaagaaac ctggagagag tctcaaaatc       60

agttgcaagg gatcaggatt ctcatttact tcctactgga taggttgggt ccgacaaatg      120

cctgggaagg gtctcgaatg gatggggatc atatatcctg gagattcaga cacaagatac      180

tccccatctt tccaggggca ggttactatt agtgcggaca aaagtatctc aacagcgtat      240

ctccagtggt ccagtctcaa ggcgagcgat actgcgatgt attattgtgc gaggggtggt      300

tatgaggacg tgttcgatat ttgggggcag ggcacgatgg tcacggtatc ttccgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgccac catgccggga cgagctgacc     1080

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatga                                         1347


<210>  184
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-HOLE-2 HCDR1

<400>  184

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  185
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-HOLE-2 HCDR2

<400>  185

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-HOLE-2 HCDR3

<400>  186

Ala Lys Asp Lys Ala Val Glu Ala Phe Asp Ile 
1               5                   10      


<210>  187
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-HOLE-2 VH

<400>  187

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Lys Ala Val Glu Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  188
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-HOLE-2 HEAVY CHAIN

<400>  188

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Lys Ala Val Glu Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
    130                 135                 140                 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
145                 150                 155                 160 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
                165                 170                 175     


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
            180                 185                 190         


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
        195                 200                 205             


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  189
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-HOLE-2 VH

<400>  189
gaggttcagc ttgtagagtc cggtggcggt ctcgttcaac ccggcgggag cctgaggctg       60

tcttgcgcgg cttcaggatt cacatttagt tcctacgcca tgtcctgggt cagacaagca      120

ccaggaaaag ggttggagtg ggtgtcagtt atctcaggtt ccggaggctc aaccagttac      180

gccgacagcg tcaaaggtcg gttcacgatc tcccgagaca attcaaagaa taccctttat      240

ctccagatga actctttgag ggcggaggac accgccgtgt actattgtgc taaggacaaa      300

gcagtagagg ctttcgacat ttgggggcag ggaactatgg tcaccgtgtc cagt            354


<210>  190
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0203 IGG1-HOLE-2 HEAVY CHAIN

<400>  190
gaggttcagc ttgtagagtc cggtggcggt ctcgttcaac ccggcgggag cctgaggctg       60

tcttgcgcgg cttcaggatt cacatttagt tcctacgcca tgtcctgggt cagacaagca      120

ccaggaaaag ggttggagtg ggtgtcagtt atctcaggtt ccggaggctc aaccagttac      180

gccgacagcg tcaaaggtcg gttcacgatc tcccgagaca attcaaagaa taccctttat      240

ctccagatga actctttgag ggcggaggac accgccgtgt actattgtgc taaggacaaa      300

gcagtagagg ctttcgacat ttgggggcag ggaactatgg tcaccgtgtc cagtgctagc      360

gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      420

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag      480

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag      540

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac      600

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc      660

aacaggggag agtgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt gcaccctgcc cccatcccgg     1080

gacgagctga ccaagaacca ggtcagcctg tcctgcgcgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctcgtcagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            1359


<210>  191
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-1 LCDR1

<400>  191

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  192
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-1 LCDR3

<400>  192

Cys Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe 
1               5                   10      


<210>  193
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-1 VL

<400>  193

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  194
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-1

<400>  194

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
        195                 200                 205             


Glu Pro Lys Ser Cys 
    210             


<210>  195
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-1 VL

<400>  195
gacattcaga tgacccaatc cccgtcaagt ctttctgcat ctgttggaga ccgagtcaca       60

atcacatgtc aagcaagtca agatataagc aactacctta attggtatca gcagaaaccg      120

gggaaggccc ccaagctgtt gatttatgat gcgtctaatc ttgagacggg agtcccatcc      180

cgattcagcg ggtctgggtc tggcacggat ttcacattta caataagctc ccttcaacca      240

gaggacattg ccacatatta ctgtcagcaa tacgataatt tgccgctgac gtttggaggt      300

gggactaagg ttgagattaa acgg                                             324


<210>  196
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-1

<400>  196
gacattcaga tgacccaatc cccgtcaagt ctttctgcat ctgttggaga ccgagtcaca       60

atcacatgtc aagcaagtca agatataagc aactacctta attggtatca gcagaaaccg      120

gggaaggccc ccaagctgtt gatttatgat gcgtctaatc ttgagacggg agtcccatcc      180

cgattcagcg ggtctgggtc tggcacggat ttcacattta caataagctc ccttcaacca      240

gaggacattg ccacatatta ctgtcagcaa tacgataatt tgccgctgac gtttggaggt      300

gggactaagg ttgagattaa acggtcgagt gctagcacca agggcccatc ggtcttcccc      360

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      480

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      540

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      600

aacaccaagg tggacaagaa agttgagccc aaatcttgtt ag                         642


<210>  197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-2 LCDR1

<400>  197

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  198
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-2 LCDR3

<400>  198

Cys Gln Gln Tyr Gly Ser Ser Pro Pro Thr Phe 
1               5                   10      


<210>  199
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-2 VL

<400>  199

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  200
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-2

<400>  200

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  201
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-2 VL

<400>  201
gaaatagtat tgacgcagtc cccagggact ctgtccctta gtcccggtgg tcgcgctacg       60

ctgagttgcc gagcctccca atcagtgtca agttcttatc ttgcttggta tcagcaaaag      120

cctggtcagg ccccaaggct tctcatctat ggcgcttcat caagagcgac tggtattcca      180

gaccgcttta gtggttcagg aagtggaacc gactttacgc tcactatctc aagactcgaa      240

cctgaagact ttgcagttta ttactgtcag cagtatggga gcagcccacc tacattcggt      300

caaggcacga aggtcgagat taagaga                                          327


<210>  202
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0203 LIGHT CHAIN-2

<400>  202
gaaatagtat tgacgcagtc cccagggact ctgtccctta gtcccggtgg tcgcgctacg       60

ctgagttgcc gagcctccca atcagtgtca agttcttatc ttgcttggta tcagcaaaag      120

cctggtcagg ccccaaggct tctcatctat ggcgcttcat caagagcgac tggtattcca      180

gaccgcttta gtggttcagg aagtggaacc gactttacgc tcactatctc aagactcgaa      240

cctgaagact ttgcagttta ttactgtcag cagtatggga gcagcccacc tacattcggt      300

caaggcacga aggtcgagat taagagaacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttag                   648


<210>  203
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-KNOB-1 HCDR1

<400>  203

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  204
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-KNOB-1 HCDR2

<400>  204

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  205
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-KNOB-1 HCDR3

<400>  205

Ala Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile 
1               5                   10          


<210>  206
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-KNOB-1 VH

<400>  206

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  207
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-KNOB-1 HEAVY CHAIN

<400>  207

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  208
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-KNOB-1 VH

<400>  208
caggtccagc tgcaagagtc cgggccgggc ctcgtaaaac cctctgagac actgtccctg       60

acttgcacgg tgtctggtgg ttctatctca tcctactatt ggtcctggat tagacagccc      120

ccagggaagg gccttgagtg gatcgggtac atatattatt cagggagcac taactacaat      180

ccttcactca agtcacgagt gactatatcc gttgacacga gcaaaaacca gttttccctc      240

aaattgagta gcgttacagc agcggataca gcagtctatt actgtgcaag aggtctcacg      300

ggaggggacg ccttcgatat atggggccag ggtacgatgg tgaccgttag ttcc            354


<210>  209
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-KNOB-1 HEAVY CHAIN

<400>  209
caggtccagc tgcaagagtc cgggccgggc ctcgtaaaac cctctgagac actgtccctg       60

acttgcacgg tgtctggtgg ttctatctca tcctactatt ggtcctggat tagacagccc      120

ccagggaagg gccttgagtg gatcgggtac atatattatt cagggagcac taactacaat      180

ccttcactca agtcacgagt gactatatcc gttgacacga gcaaaaacca gttttccctc      240

aaattgagta gcgttacagc agcggataca gcagtctatt actgtgcaag aggtctcacg      300

ggaggggacg ccttcgatat atggggccag ggtacgatgg tgaccgttag ttccgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgccac catgccggga cgagctgacc     1080

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatga                                         1347


<210>  210
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-HOLE-2 HCDR1

<400>  210

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  211
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-HOLE-2 HCDR2

<400>  211

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  212
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-HOLE-2 HCDR3

<400>  212

Ala Lys Asp Lys Ala Val Glu Ala Phe Asp Ile 
1               5                   10      


<210>  213
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-HOLE-2 VH

<400>  213

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Lys Ala Val Glu Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  214
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-HOLE-2 HEAVY CHAIN

<400>  214

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Lys Ala Val Glu Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
    130                 135                 140                 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
145                 150                 155                 160 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
                165                 170                 175     


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
            180                 185                 190         


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
        195                 200                 205             


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  215
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-HOLE-2 VH

<400>  215
gaggttcagc ttgtagagtc cggtggcggt ctcgttcaac ccggcgggag cctgaggctg       60

tcttgcgcgg cttcaggatt cacatttagt tcctacgcca tgtcctgggt cagacaagca      120

ccaggaaaag ggttggagtg ggtgtcagtt atctcaggtt ccggaggctc aaccagttac      180

gccgacagcg tcaaaggtcg gttcacgatc tcccgagaca attcaaagaa taccctttat      240

ctccagatga actctttgag ggcggaggac accgccgtgt actattgtgc taaggacaaa      300

gcagtagagg ctttcgacat ttgggggcag ggaactatgg tcaccgtgtc cagt            354


<210>  216
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0803 IGG1-HOLE-2 HEAVY CHAIN

<400>  216
gaggttcagc ttgtagagtc cggtggcggt ctcgttcaac ccggcgggag cctgaggctg       60

tcttgcgcgg cttcaggatt cacatttagt tcctacgcca tgtcctgggt cagacaagca      120

ccaggaaaag ggttggagtg ggtgtcagtt atctcaggtt ccggaggctc aaccagttac      180

gccgacagcg tcaaaggtcg gttcacgatc tcccgagaca attcaaagaa taccctttat      240

ctccagatga actctttgag ggcggaggac accgccgtgt actattgtgc taaggacaaa      300

gcagtagagg ctttcgacat ttgggggcag ggaactatgg tcaccgtgtc cagtgctagc      360

gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      420

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag      480

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag      540

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac      600

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc      660

aacaggggag agtgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt gcaccctgcc cccatcccgg     1080

gacgagctga ccaagaacca ggtcagcctg tcctgcgcgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctcgtcagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            1359


<210>  217
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-1 LCDR1

<400>  217

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  218
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-1 LCDR3

<400>  218

Cys Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe 
1               5                   10      


<210>  219
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-1 VL

<400>  219

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  220
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-1

<400>  220

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
        195                 200                 205             


Glu Pro Lys Ser Cys 
    210             


<210>  221
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-1 VL

<400>  221
gacattcaga tgacccaatc cccgtcaagt ctttctgcat ctgttggaga ccgagtcaca       60

atcacatgtc aagcaagtca agatataagc aactacctta attggtatca gcagaaaccg      120

gggaaggccc ccaagctgtt gatttatgat gcgtctaatc ttgagacggg agtcccatcc      180

cgattcagcg ggtctgggtc tggcacggat ttcacattta caataagctc ccttcaacca      240

gaggacattg ccacatatta ctgtcagcaa tacgataatt tgccgctgac gtttggaggt      300

gggactaagg ttgagattaa acgg                                             324


<210>  222
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-1

<400>  222
gacattcaga tgacccaatc cccgtcaagt ctttctgcat ctgttggaga ccgagtcaca       60

atcacatgtc aagcaagtca agatataagc aactacctta attggtatca gcagaaaccg      120

gggaaggccc ccaagctgtt gatttatgat gcgtctaatc ttgagacggg agtcccatcc      180

cgattcagcg ggtctgggtc tggcacggat ttcacattta caataagctc ccttcaacca      240

gaggacattg ccacatatta ctgtcagcaa tacgataatt tgccgctgac gtttggaggt      300

gggactaagg ttgagattaa acggtcgagt gctagcacca agggcccatc ggtcttcccc      360

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      480

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      540

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      600

aacaccaagg tggacaagaa agttgagccc aaatcttgtt ag                         642


<210>  223
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-2 LCDR1

<400>  223

Gln Ser Val Leu Tyr Ser Ser Asn Asn Glu Asn Tyr 
1               5                   10          


<210>  224
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-2 LCDR3

<400>  224

Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  225
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-2 VL

<400>  225

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  226
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-2

<400>  226

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  227
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-2 VL

<400>  227
gacattgtaa tgacacagag ccccgactcc ctggccgtgt ctttgggcga gagagcaacc       60

attaattgta agtctagcca aagtgtcctg tattcatcta acaacgagaa ttatttggcc      120

tggtatcaac agaagcctgg acagccaccg aaacttctta tctattgggc gtcaaccaga      180

gagagcggtg tgccagaccg gtttagcgga tctggttctg gaactgattt tactttgacc      240

atatctagcc tccaggcgga agacgtagcg gtctattact gccaacagta ttattccacc      300

ccgttgacct tcggaggcgg aacaaaggtt gaaatcaaga ga                         342


<210>  228
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0803 LIGHT CHAIN-2

<400>  228
gacattgtaa tgacacagag ccccgactcc ctggccgtgt ctttgggcga gagagcaacc       60

attaattgta agtctagcca aagtgtcctg tattcatcta acaacgagaa ttatttggcc      120

tggtatcaac agaagcctgg acagccaccg aaacttctta tctattgggc gtcaaccaga      180

gagagcggtg tgccagaccg gtttagcgga tctggttctg gaactgattt tactttgacc      240

atatctagcc tccaggcgga agacgtagcg gtctattact gccaacagta ttattccacc      300

ccgttgacct tcggaggcgg aacaaaggtt gaaatcaaga gaacggtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660

tag                                                                    663


<210>  229
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFSFTSYW

<400>  229

Gly Phe Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  230
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-KNOB-1 HCDR2

<400>  230

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  231
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-KNOB-1 HCDR3

<400>  231

Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile 
1               5                   10      


<210>  232
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-KNOB-1 VH

<400>  232

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  233
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-KNOB-1 HEAVY CHAIN

<400>  233

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Glu Asp Val Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  234
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-KNOB-1 VH

<400>  234
gaagttcaac ttgttcaaag cggcgcagag gtaaagaaac ctggagagag tctcaaaatc       60

agttgcaagg gatcaggatt ctcatttact tcctactgga taggttgggt ccgacaaatg      120

cctgggaagg gtctcgaatg gatggggatc atatatcctg gagattcaga cacaagatac      180

tccccatctt tccaggggca ggttactatt agtgcggaca aaagtatctc aacagcgtat      240

ctccagtggt ccagtctcaa ggcgagcgat actgcgatgt attattgtgc gaggggtggt      300

tatgaggacg tgttcgatat ttgggggcag ggcacgatgg tcacggtatc ttcc            354


<210>  235
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-KNOB-1 HEAVY CHAIN

<400>  235
gaagttcaac ttgttcaaag cggcgcagag gtaaagaaac ctggagagag tctcaaaatc       60

agttgcaagg gatcaggatt ctcatttact tcctactgga taggttgggt ccgacaaatg      120

cctgggaagg gtctcgaatg gatggggatc atatatcctg gagattcaga cacaagatac      180

tccccatctt tccaggggca ggttactatt agtgcggaca aaagtatctc aacagcgtat      240

ctccagtggt ccagtctcaa ggcgagcgat actgcgatgt attattgtgc gaggggtggt      300

tatgaggacg tgttcgatat ttgggggcag ggcacgatgg tcacggtatc ttccgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgccac catgccggga cgagctgacc     1080

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatga                                         1347


<210>  236
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-HOLE-2 HCDR1

<400>  236

Gly Phe Thr Phe Thr Gly Tyr Ser 
1               5               


<210>  237
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-HOLE-2 HCDR2

<400>  237

Ile Asn Pro Ser Thr Gly Gly Thr 
1               5               


<210>  238
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-HOLE-2 HCDR3

<400>  238

Ala Arg Ser Arg Gly Asp Tyr 
1               5           


<210>  239
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-HOLE-2 VH

<400>  239

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ser Met Asn Trp Met Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  240
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-HOLE-2 HEAVY CHAIN

<400>  240

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ser Met Asn Trp Met Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        115                 120                 125             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    130                 135                 140                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
145                 150                 155                 160 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                165                 170                 175     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            180                 185                 190         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        195                 200                 205             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  241
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-HOLE-2 VH

<400>  241
gaggttcagc ttgtggaatc agggggtggg ctggtccagc ctgggggatc tttgcgactg       60

agttgtgctg cttcaggttt cacatttact ggctacagca tgaactggat gcggcaagcg      120

ccaggcaaag ggcttgaatg ggtggcggag atcaatccat ccacaggagg cacgaccgat      180

aaccagaaat ttaaggcgag gtttaccata agtagagata actctaaaaa cacgctctat      240

ctccaaatga acagtctgcg ggcggaggat actgcagtct actattgcgc ccgcagccga      300

ggggactatt gggggcaggg cactttggtt acagtgtcca gc                         342


<210>  242
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0213 IGG1-HOLE-2 HEAVY CHAIN

<400>  242
gaggttcagc ttgtggaatc agggggtggg ctggtccagc ctgggggatc tttgcgactg       60

agttgtgctg cttcaggttt cacatttact ggctacagca tgaactggat gcggcaagcg      120

ccaggcaaag ggcttgaatg ggtggcggag atcaatccat ccacaggagg cacgaccgat      180

aaccagaaat ttaaggcgag gtttaccata agtagagata actctaaaaa cacgctctat      240

ctccaaatga acagtctgcg ggcggaggat actgcagtct actattgcgc ccgcagccga      300

ggggactatt gggggcaggg cactttggtt acagtgtcca gcgctagcgt ggctgcacca      360

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg      420

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc      480

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac      540

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc      600

tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa agagcttcaa caggggagag      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtgc accctgcccc catcccggga cgagctgacc     1080

aagaaccagg tcagcctgtc ctgcgcggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct cgtcagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatga                                         1347


<210>  243
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-1 LCDR1

<400>  243

Ser Val Glu Tyr Tyr Gly Thr Ser 
1               5               


<210>  244
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-1 LCDR3

<400>  244

Gln Gln Ser Arg Lys Val Pro Trp Thr 
1               5                   


<210>  245
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-1 VH

<400>  245

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  246
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-1

<400>  246

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215         


<210>  247
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-1 VH

<400>  247
gacattcaga tgacacaatc cccctctagc ctgtcagcgt ccgtgggcga ccgagttacg       60

attacctgcc gagcatcaga atccgtagag tattatggca cgtctcttat gcaatggtat      120

cagcagaaac cgggtaaagc gccaaaactg ctcatctacg cggcgtctaa cgtggagtca      180

ggtgtacccg ccagattttc tggttcagga agcgggactg attttacatt gactataagc      240

tcactgcaac cggaagattt cgctacctac tattgtcaac aatcacggaa ggtcccatgg      300

accttcgggc agggtactaa agtcgagatt aaaagg                                336


<210>  248
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-1

<400>  248
gacattcaga tgacacaatc cccctctagc ctgtcagcgt ccgtgggcga ccgagttacg       60

attacctgcc gagcatcaga atccgtagag tattatggca cgtctcttat gcaatggtat      120

cagcagaaac cgggtaaagc gccaaaactg ctcatctacg cggcgtctaa cgtggagtca      180

ggtgtacccg ccagattttc tggttcagga agcgggactg attttacatt gactataagc      240

tcactgcaac cggaagattt cgctacctac tattgtcaac aatcacggaa ggtcccatgg      300

accttcgggc agggtactaa agtcgagatt aaaaggtcga gtgctagcac caagggccca      360

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      420

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      480

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      540

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      600

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg ttag            654


<210>  249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-2 LCDR1

<400>  249

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  250
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-2 LCDR3

<400>  250

Cys Gln Gln Tyr Gly Ser Ser Pro Pro Thr Phe 
1               5                   10      


<210>  251
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-2 VL

<400>  251

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  252
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-2

<400>  252

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  253
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-2 VL

<400>  253
gaaatagtat tgacgcagtc cccagggact ctgtccctta gtcccggtgg tcgcgctacg       60

ctgagttgcc gagcctccca atcagtgtca agttcttatc ttgcttggta tcagcaaaag      120

cctggtcagg ccccaaggct tctcatctat ggcgcttcat caagagcgac tggtattcca      180

gaccgcttta gtggttcagg aagtggaacc gactttacgc tcactatctc aagactcgaa      240

cctgaagact ttgcagttta ttactgtcag cagtatggga gcagcccacc tacattcggt      300

caaggcacga aggtcgagat taagaga                                          327


<210>  254
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0213 LIGHT CHAIN-2

<400>  254
gaaatagtat tgacgcagtc cccagggact ctgtccctta gtcccggtgg tcgcgctacg       60

ctgagttgcc gagcctccca atcagtgtca agttcttatc ttgcttggta tcagcaaaag      120

cctggtcagg ccccaaggct tctcatctat ggcgcttcat caagagcgac tggtattcca      180

gaccgcttta gtggttcagg aagtggaacc gactttacgc tcactatctc aagactcgaa      240

cctgaagact ttgcagttta ttactgtcag cagtatggga gcagcccacc tacattcggt      300

caaggcacga aggtcgagat taagagaacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttag                   648


<210>  255
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-KNOB-1 HCDR1

<400>  255

Gly Gly Ser Ile Ser Ser Tyr Tyr 
1               5               


<210>  256
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-KNOB-1 HCDR2

<400>  256

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  257
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-KNOB-1 HCDR3

<400>  257

Ala Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile 
1               5                   10          


<210>  258
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-KNOB-1 VH

<400>  258

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  259
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-KNOB-1 HEAVY CHAIN

<400>  259

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Thr Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  260
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-KNOB-1 VH

<400>  260
caggtccagc tgcaagagtc cgggccgggc ctcgtaaaac cctctgagac actgtccctg       60

acttgcacgg tgtctggtgg ttctatctca tcctactatt ggtcctggat tagacagccc      120

ccagggaagg gccttgagtg gatcgggtac atatattatt cagggagcac taactacaat      180

ccttcactca agtcacgagt gactatatcc gttgacacga gcaaaaacca gttttccctc      240

aaattgagta gcgttacagc agcggataca gcagtctatt actgtgcaag aggtctcacg      300

ggaggggacg ccttcgatat atggggccag ggtacgatgg tgaccgttag ttcc            354


<210>  261
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-KNOB-1 HEAVY CHAIN

<400>  261
caggtccagc tgcaagagtc cgggccgggc ctcgtaaaac cctctgagac actgtccctg       60

acttgcacgg tgtctggtgg ttctatctca tcctactatt ggtcctggat tagacagccc      120

ccagggaagg gccttgagtg gatcgggtac atatattatt cagggagcac taactacaat      180

ccttcactca agtcacgagt gactatatcc gttgacacga gcaaaaacca gttttccctc      240

aaattgagta gcgttacagc agcggataca gcagtctatt actgtgcaag aggtctcacg      300

ggaggggacg ccttcgatat atggggccag ggtacgatgg tgaccgttag ttccgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgccac catgccggga cgagctgacc     1080

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatga                                         1347


<210>  262
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-HOLE-2 HCDR1

<400>  262

Gly Phe Thr Phe Thr Gly Tyr Ser 
1               5               


<210>  263
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-HOLE-2 HCDR2

<400>  263

Ile Asn Pro Ser Thr Gly Gly Thr 
1               5               


<210>  264
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-HOLE-2 HCDR3

<400>  264

Ala Arg Ser Arg Gly Asp Tyr 
1               5           


<210>  265
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-HOLE-2 VH

<400>  265

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ser Met Asn Trp Met Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  266
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-HOLE-2 HEAVY CHAIN

<400>  266

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Gly Tyr 
            20                  25                  30          


Ser Met Asn Trp Met Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Asn Pro Ser Thr Gly Gly Thr Thr Asp Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        115                 120                 125             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    130                 135                 140                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
145                 150                 155                 160 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                165                 170                 175     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            180                 185                 190         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        195                 200                 205             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  267
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-HOLE-2 VH

<400>  267
gaggttcagc ttgtggaatc agggggtggg ctggtccagc ctgggggatc tttgcgactg       60

agttgtgctg cttcaggttt cacatttact ggctacagca tgaactggat gcggcaagcg      120

ccaggcaaag ggcttgaatg ggtggcggag atcaatccat ccacaggagg cacgaccgat      180

aaccagaaat ttaaggcgag gtttaccata agtagagata actctaaaaa cacgctctat      240

ctccaaatga acagtctgcg ggcggaggat actgcagtct actattgcgc ccgcagccga      300

ggggactatt gggggcaggg cactttggtt acagtgtcca gc                         342


<210>  268
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0813 IGG1-HOLE-2 HEAVY CHAIN

<400>  268
gaggttcagc ttgtggaatc agggggtggg ctggtccagc ctgggggatc tttgcgactg       60

agttgtgctg cttcaggttt cacatttact ggctacagca tgaactggat gcggcaagcg      120

ccaggcaaag ggcttgaatg ggtggcggag atcaatccat ccacaggagg cacgaccgat      180

aaccagaaat ttaaggcgag gtttaccata agtagagata actctaaaaa cacgctctat      240

ctccaaatga acagtctgcg ggcggaggat actgcagtct actattgcgc ccgcagccga      300

ggggactatt gggggcaggg cactttggtt acagtgtcca gcgctagcgt ggctgcacca      360

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg      420

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc      480

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac      540

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc      600

tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa agagcttcaa caggggagag      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtgc accctgcccc catcccggga cgagctgacc     1080

aagaaccagg tcagcctgtc ctgcgcggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct cgtcagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatga                                         1347


<210>  269
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-1 LCDR1

<400>  269

Ser Val Glu Tyr Tyr Gly Thr Ser 
1               5               


<210>  270
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-1 LCDR3

<400>  270

Gln Gln Ser Arg Lys Val Pro Trp Thr 
1               5                   


<210>  271
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-1 VL

<400>  271

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  272
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-1

<400>  272

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215         


<210>  273
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-1 VL

<400>  273
gacattcaga tgacacaatc cccctctagc ctgtcagcgt ccgtgggcga ccgagttacg       60

attacctgcc gagcatcaga atccgtagag tattatggca cgtctcttat gcaatggtat      120

cagcagaaac cgggtaaagc gccaaaactg ctcatctacg cggcgtctaa cgtggagtca      180

ggtgtacccg ccagattttc tggttcagga agcgggactg attttacatt gactataagc      240

tcactgcaac cggaagattt cgctacctac tattgtcaac aatcacggaa ggtcccatgg      300

accttcgggc agggtactaa agtcgagatt aaaagg                                336


<210>  274
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-1

<400>  274
gacattcaga tgacacaatc cccctctagc ctgtcagcgt ccgtgggcga ccgagttacg       60

attacctgcc gagcatcaga atccgtagag tattatggca cgtctcttat gcaatggtat      120

cagcagaaac cgggtaaagc gccaaaactg ctcatctacg cggcgtctaa cgtggagtca      180

ggtgtacccg ccagattttc tggttcagga agcgggactg attttacatt gactataagc      240

tcactgcaac cggaagattt cgctacctac tattgtcaac aatcacggaa ggtcccatgg      300

accttcgggc agggtactaa agtcgagatt aaaaggtcga gtgctagcac caagggccca      360

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      420

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      480

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      540

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      600

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg ttag            654


<210>  275
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-2 LCDR1

<400>  275

Gln Ser Val Leu Tyr Ser Ser Asn Asn Glu Asn Tyr 
1               5                   10          


<210>  276
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-2 LCDR3

<400>  276

Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  277
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-2 VL

<400>  277

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  278
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-2

<400>  278

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Glu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  279
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-2 VL

<400>  279
gacattgtaa tgacacagag ccccgactcc ctggccgtgt ctttgggcga gagagcaacc       60

attaattgta agtctagcca aagtgtcctg tattcatcta acaacgagaa ttatttggcc      120

tggtatcaac agaagcctgg acagccaccg aaacttctta tctattgggc gtcaaccaga      180

gagagcggtg tgccagaccg gtttagcgga tctggttctg gaactgattt tactttgacc      240

atatctagcc tccaggcgga agacgtagcg gtctattact gccaacagta ttattccacc      300

ccgttgacct tcggaggcgg aacaaaggtt gaaatcaaga ga                         342


<210>  280
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COV2-0813 LIGHT CHAIN-2

<400>  280
gacattgtaa tgacacagag ccccgactcc ctggccgtgt ctttgggcga gagagcaacc       60

attaattgta agtctagcca aagtgtcctg tattcatcta acaacgagaa ttatttggcc      120

tggtatcaac agaagcctgg acagccaccg aaacttctta tctattgggc gtcaaccaga      180

gagagcggtg tgccagaccg gtttagcgga tctggttctg gaactgattt tactttgacc      240

atatctagcc tccaggcgga agacgtagcg gtctattact gccaacagta ttattccacc      300

ccgttgacct tcggaggcgg aacaaaggtt gaaatcaaga gaacggtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660

tag                                                                    663


<210>  281
<211>  4178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Omicr-MB_VK2

<400>  281
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca      600

cttgtcacga attcagaaat agtattgacg cagtccccag ggactctgtc ccttagtccc      660

ggtggtcgcg ctacgctgag ttgccgagcc tcccaatcag tgtcaagttc ttatcttgct      720

tggtatcagc aaaagcctgg tcaggcccca aggcttctca tctatggcgc ttcatcaaga      780

gcgactggta ttccagaccg ctttagtggt tcaggaagtg gaaccgactt tacgctcact      840

atctcaagac tcgaacctga agactttgca gtttattact gtcagcagta tgggagcagc      900

ccacctacat tcggtcaagg cacgaaggtc gagattaaga gaacggtggc tgcaccatct      960

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc     1020

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc     1080

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc     1140

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc     1200

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     1260

tagagggagc tagctcgaca tgataagata cattgatgag tttggacaaa ccacaactag     1320

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtgaa     1380

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac     1440

aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc     1500

aagtaaaacc tctacaaatg tggtatggaa ttaattctaa aatacagcat agcaaaactt     1560

taacctccaa atcaagcctc tacttgaatc cttttctgag ggatgaataa ggcataggca     1620

tcaggggctg ttgccaatgt gcattagctg tttgcagcct caccttcttt catggagttt     1680

aagatatagt gtattttccc aaggtttgaa ctagctcttc atttctttat gttttaaatg     1740

cactgacctc ccacattccc tttttagtaa aatattcaga aataatttaa atacatcatt     1800

gcaatgaaaa taaatgtttt ttattaggca gaatccagat gctcaaggcc cttcataata     1860

tcccccagtt tagtagttgg acttagggaa caaaggaacc tttaatagaa attggacagc     1920

aagaaagcga gcttctagct ttagttcctg gtgtacttga gggggatgag ttcctcaatg     1980

gtggttttga ccagcttgcc attcatctca atgagcacaa agcagtcagg agcatagtca     2040

gagatgagct ctctgcacat gccacagggg ctgaccaccc tgatggatct gtccacctca     2100

tcagagtagg ggtgcctgac agccacaatg gtgtcaaagt ccttctgccc gttgctcaca     2160

gcagacccaa tggcaatggc ttcagcacag acagtgaccc tgccaatgta ggcctcaatg     2220

tggacagcag agatgatctc cccagtcttg gtcctgatgg ccgccccgac atggtgcttg     2280

ttgtcctcat agagcatggt gatcttctca gtggcgacct ccaccagctc cagatcctgc     2340

tgagagatgt tgaaggtctt catgatggct cctcctgtca ggagaggaaa gagaagaagg     2400

ttagtacaat tgctatagtg agttgtatta tactatgctt atgattaatt gtcaaactag     2460

ggctgcaggg ttcatagtgc cacttttcct gcactgcccc atctcctgcc caccctttcc     2520

caggcataga cagtcagtga cttaccaaac tcacaggagg gagaaggcag aagcttgaga     2580

cagacccgcg ggaccgccga actgcgaggg gacgtggcta gggcggcttc ttttatggtg     2640

cgccggccct cggaggcagg gcgctcgggg aggcctagcg gccaatctgc ggtggcagga     2700

ggcggggccg aaggccgtgc ctgaccaatc cggagcacat aggagtctca gccccccgcc     2760

ccaaagcaag gggaagtcac gcgcctgtag cgccagcgtg ttgtgaaatg ggggcttggg     2820

ggggttgggg ccctgactag tcaaaacaaa ctcccattga cgtcaatggg gtggagactt     2880

ggaaatcccc gtgagtcaaa ccgctatcca cgcccattga tgtactgcca aaaccgcatc     2940

atcatggtaa tagcgatgac taatacgtag atgtactgcc aagtaggaaa gtcccataag     3000

gtcatgtact gggcataatg ccaggcgggc catttaccgt cattgacgtc aatagggggc     3060

gtacttggca tatgatacac ttgatgtact gccaagtggg cagtttaccg taaatactcc     3120

acccattgac gtcaatggaa agtccctatt ggcgttacta tgggaacata cgtcattatt     3180

gacgtcaatg ggcgggggtc gttgggcggt cagccaggcg ggccatttac cgtaagttat     3240

gtaacgcctg caggttaatt aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3300

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3360

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3420

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3480

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3540

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3600

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3660

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3720

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta     3780

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3840

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3900

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     3960

aaaactcacg ttaagggatt ttggtcatgg ctagttaatt aacatttaaa tcagcggccg     4020

caataaaata tctttatttt cattacatct gtgtgttggt tttttgtgtg aatcgtaact     4080

aacatacgct ctccatcaaa acaaaacgaa acaaaacaaa ctagcaaaat aggctgtccc     4140

cagtgcaagt gcaggtgcca gaacatttct ctatcgaa                             4178


<210>  282
<211>  4193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Omicr-MB_VK8

<400>  282
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca      600

cttgtcacga attcagacat tgtaatgaca cagagccccg actccctggc cgtgtctttg      660

ggcgagagag caaccattaa ttgtaagtct agccaaagtg tcctgtattc atctaacaac      720

gagaattatt tggcctggta tcaacagaag cctggacagc caccgaaact tcttatctat      780

tgggcgtcaa ccagagagag cggtgtgcca gaccggttta gcggatctgg ttctggaact      840

gattttactt tgaccatatc tagcctccag gcggaagacg tagcggtcta ttactgccaa      900

cagtattatt ccaccccgtt gaccttcgga ggcggaacaa aggttgaaat caagagaacg      960

gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact     1020

gcctctgttg tgtgcctgct gaataacttc tatcccagag aggccaaagt acagtggaag     1080

gtggataacg ccctccaatc gggtaactcc caggagagtg tcacagagca ggacagcaag     1140

gacagcacct acagcctcag cagcaccctg acgctgagca aagcagacta cgagaaacac     1200

aaagtctacg cctgcgaagt cacccatcag ggcctgagct cgcccgtcac aaagagcttc     1260

aacaggggag agtgttagag ggagctagct cgacatgata agatacattg atgagtttgg     1320

acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat     1380

tgctttattt gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat     1440

aaacaagtta acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggaggtgtgg     1500

gaggtttttt aaagcaagta aaacctctac aaatgtggta tggaattaat tctaaaatac     1560

agcatagcaa aactttaacc tccaaatcaa gcctctactt gaatcctttt ctgagggatg     1620

aataaggcat aggcatcagg ggctgttgcc aatgtgcatt agctgtttgc agcctcacct     1680

tctttcatgg agtttaagat atagtgtatt ttcccaaggt ttgaactagc tcttcatttc     1740

tttatgtttt aaatgcactg acctcccaca ttcccttttt agtaaaatat tcagaaataa     1800

tttaaataca tcattgcaat gaaaataaat gttttttatt aggcagaatc cagatgctca     1860

aggcccttca taatatcccc cagtttagta gttggactta gggaacaaag gaacctttaa     1920

tagaaattgg acagcaagaa agcgagcttc tagctttagt tcctggtgta cttgaggggg     1980

atgagttcct caatggtggt tttgaccagc ttgccattca tctcaatgag cacaaagcag     2040

tcaggagcat agtcagagat gagctctctg cacatgccac aggggctgac caccctgatg     2100

gatctgtcca cctcatcaga gtaggggtgc ctgacagcca caatggtgtc aaagtccttc     2160

tgcccgttgc tcacagcaga cccaatggca atggcttcag cacagacagt gaccctgcca     2220

atgtaggcct caatgtggac agcagagatg atctccccag tcttggtcct gatggccgcc     2280

ccgacatggt gcttgttgtc ctcatagagc atggtgatct tctcagtggc gacctccacc     2340

agctccagat cctgctgaga gatgttgaag gtcttcatga tggctcctcc tgtcaggaga     2400

ggaaagagaa gaaggttagt acaattgcta tagtgagttg tattatacta tgcttatgat     2460

taattgtcaa actagggctg cagggttcat agtgccactt ttcctgcact gccccatctc     2520

ctgcccaccc tttcccaggc atagacagtc agtgacttac caaactcaca ggagggagaa     2580

ggcagaagct tgagacagac ccgcgggacc gccgaactgc gaggggacgt ggctagggcg     2640

gcttctttta tggtgcgccg gccctcggag gcagggcgct cggggaggcc tagcggccaa     2700

tctgcggtgg caggaggcgg ggccgaaggc cgtgcctgac caatccggag cacataggag     2760

tctcagcccc ccgccccaaa gcaaggggaa gtcacgcgcc tgtagcgcca gcgtgttgtg     2820

aaatgggggc ttgggggggt tggggccctg actagtcaaa acaaactccc attgacgtca     2880

atggggtgga gacttggaaa tccccgtgag tcaaaccgct atccacgccc attgatgtac     2940

tgccaaaacc gcatcatcat ggtaatagcg atgactaata cgtagatgta ctgccaagta     3000

ggaaagtccc ataaggtcat gtactgggca taatgccagg cgggccattt accgtcattg     3060

acgtcaatag ggggcgtact tggcatatga tacacttgat gtactgccaa gtgggcagtt     3120

taccgtaaat actccaccca ttgacgtcaa tggaaagtcc ctattggcgt tactatggga     3180

acatacgtca ttattgacgt caatgggcgg gggtcgttgg gcggtcagcc aggcgggcca     3240

tttaccgtaa gttatgtaac gcctgcaggt taattaagaa catgtgagca aaaggccagc     3300

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     3360

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     3420

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     3480

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     3540

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     3600

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     3660

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     3720

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     3780

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     3840

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc     3900

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg     3960

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catggctagt taattaacat     4020

ttaaatcagc ggccgcaata aaatatcttt attttcatta catctgtgtg ttggtttttt     4080

gtgtgaatcg taactaacat acgctctcca tcaaaacaaa acgaaacaaa acaaactagc     4140

aaaataggct gtccccagtg caagtgcagg tgccagaaca tttctctatc gaa            4193


<210>  283
<211>  4836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPR146 pfuse-IgG1-Knob-MB.08-VH-CH1-CH2-CH3

<400>  283
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cgcaggtcca gctgcaagag tccgggccgg      660

gcctcgtaaa accctctgag acactgtccc tgacttgcac ggtgtctggt ggttctatct      720

catcctacta ttggtcctgg attagacagc ccccagggaa gggccttgag tggatcgggt      780

acatatatta ttcagggagc actaactaca atccttcact caagtcacga gtgactatat      840

ccgttgacac gagcaaaaac cagttttccc tcaaattgag tagcgttaca gcagcggata      900

cagcagtcta ttactgtgca agaggtctca cgggagggga cgccttcgat atatggggcc      960

agggtacgat ggtgaccgtt agttccgcta gcaccaaggg cccatcggtc ttccccctgg     1020

caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg gtcaaggact     1080

acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca     1140

ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg gtgaccgtgc     1200

cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag cccagcaaca     1260

ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca tgcccaccgt     1320

gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg     1380

acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg     1440

aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga     1500

caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc     1560

tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc     1620

cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt     1680

acaccctgcc accatgccgg gacgagctga ccaagaacca ggtcagcctg tggtgcctgg     1740

tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga     1800

acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca     1860

agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc     1920

atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg ggtaaatgag     1980

tcctagctgg ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat     2040

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     2100

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     2160

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggaatt     2220

aattctaaaa tacagcatag caaaacttta acctccaaat caagcctcta cttgaatcct     2280

tttctgaggg atgaataagg cataggcatc aggggctgtt gccaatgtgc attagctgtt     2340

tgcagcctca ccttctttca tggagtttaa gatatagtgt attttcccaa ggtttgaact     2400

agctcttcat ttctttatgt tttaaatgca ctgacctccc acattccctt tttagtaaaa     2460

tattcagaaa taatttaaat acatcattgc aatgaaaata aatgtttttt attaggcaga     2520

atccagatgc tcaaggccct tcataatatc ccccagttta gtagttggac ttagggaaca     2580

aaggaacctt taatagaaat tggacagcaa gaaagcgagc ttctagctta tcctcagtcc     2640

tgctcctctg ccacaaagtg cacgcagttg ccggccgggt cgcgcagggc gaactcccgc     2700

ccccacggct gctcgccgat ctcggtcatg gccggcccgg aggcgtcccg gaagttcgtg     2760

gacacgacct ccgaccactc ggcgtacagc tcgtccaggc cgcgcaccca cacccaggcc     2820

agggtgttgt ccggcaccac ctggtcctgg accgcgctga tgaacagggt cacgtcgtcc     2880

cggaccacac cggcgaagtc gtcctccacg aagtcccggg agaacccgag ccggtcggtc     2940

cagaactcga ccgctccggc gacgtcgcgc gcggtgagca ccggaacggc actggtcaac     3000

ttggccatga tggctcctcc tgtcaggaga ggaaagagaa gaaggttagt acaattgcta     3060

tagtgagttg tattatacta tgcagatata ctatgccaat gattaattgt caaactaggg     3120

ctgcagggtt catagtgcca cttttcctgc actgccccat ctcctgccca ccctttccca     3180

ggcatagaca gtcagtgact taccaaactc acaggaggga gaaggcagaa gcttgagaca     3240

gacccgcggg accgccgaac tgcgagggga cgtggctagg gcggcttctt ttatggtgcg     3300

ccggccctcg gaggcagggc gctcggggag gcctagcggc caatctgcgg tggcaggagg     3360

cggggccgaa ggccgtgcct gaccaatccg gagcacatag gagtctcagc cccccgcccc     3420

aaagcaaggg gaagtcacgc gcctgtagcg ccagcgtgtt gtgaaatggg ggcttggggg     3480

ggttggggcc ctgactagtc aaaacaaact cccattgacg tcaatggggt ggagacttgg     3540

aaatccccgt gagtcaaacc gctatccacg cccattgatg tactgccaaa accgcatcat     3600

catggtaata gcgatgacta atacgtagat gtactgccaa gtaggaaagt cccataaggt     3660

catgtactgg gcataatgcc aggcgggcca tttaccgtca ttgacgtcaa tagggggcgt     3720

acttggcata tgatacactt gatgtactgc caagtgggca gtttaccgta aatactccac     3780

ccattgacgt caatggaaag tccctattgg cgttactatg ggaacatacg tcattattga     3840

cgtcaatggg cgggggtcgt tgggcggtca gccaggcggg ccatttaccg taagttatgt     3900

aacgcctgca ggttaattaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3960

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     4020

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     4080

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     4140

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     4200

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     4260

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     4320

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4380

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     4440

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4500

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4560

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4620

aactcacgtt aagggatttt ggtcatggct agttaattaa catttaaatc agcggccgca     4680

ataaaatatc tttattttca ttacatctgt gtgttggttt tttgtgtgaa tcgtaactaa     4740

catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag gctgtcccca     4800

gtgcaagtgc aggtgccaga acatttctct atcgaa                               4836


<210>  284
<211>  4184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPR148 pFUSE-IgG-Clone13A-VL-CH1

<400>  284
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca      600

cttgtcacga attcagacat tcagatgaca caatccccct ctagcctgtc agcgtccgtg      660

ggcgaccgag ttacgattac ctgccgagca tcagaatccg tagagtatta tggcacgtct      720

cttatgcaat ggtatcagca gaaaccgggt aaagcgccaa aactgctcat ctacgcggcg      780

tctaacgtgg agtcaggtgt acccgccaga ttttctggtt caggaagcgg gactgatttt      840

acattgacta taagctcact gcaaccggaa gatttcgcta cctactattg tcaacaatca      900

cggaaggtcc catggacctt cgggcagggt actaaagtcg agattaaaag gtcgagtgct      960

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc     1020

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg     1080

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga     1140

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     1200

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa     1260

tcttgttaga gggagcaagc tcgacatgat aagatacatt gatgagtttg gacaaaccac     1320

aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt     1380

tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt     1440

aacaacaaca attgcattca ttttatgttt caggttcagg gggaggtgtg ggaggttttt     1500

taaagcaagt aaaacctcta caaatgtggt atggaattaa ttctaaaata cagcatagca     1560

aaactttaac ctccaaatca agcctctact tgaatccttt tctgagggat gaataaggca     1620

taggcatcag gggctgttgc caatgtgcat tagctgtttg cagcctcacc ttctttcatg     1680

gagtttaaga tatagtgtat tttcccaagg tttgaactag ctcttcattt ctttatgttt     1740

taaatgcact gacctcccac attccctttt tagtaaaata ttcagaaata atttaaatac     1800

atcattgcaa tgaaaataaa tgttttttat taggcagaat ccagatgctc aaggcccttc     1860

ataatatccc ccagtttagt agttggactt agggaacaaa ggaaccttta atagaaattg     1920

gacagcaaga aagcgagctt ctagctttag ttcctggtgt acttgagggg gatgagttcc     1980

tcaatggtgg ttttgaccag cttgccattc atctcaatga gcacaaagca gtcaggagca     2040

tagtcagaga tgagctctct gcacatgcca caggggctga ccaccctgat ggatctgtcc     2100

acctcatcag agtaggggtg cctgacagcc acaatggtgt caaagtcctt ctgcccgttg     2160

ctcacagcag acccaatggc aatggcttca gcacagacag tgaccctgcc aatgtaggcc     2220

tcaatgtgga cagcagagat gatctcccca gtcttggtcc tgatggccgc cccgacatgg     2280

tgcttgttgt cctcatagag catggtgatc ttctcagtgg cgacctccac cagctccaga     2340

tcctgctgag agatgttgaa ggtcttcatg atggctcctc ctgtcaggag aggaaagaga     2400

agaaggttag tacaattgct atagtgagtt gtattatact atgcttatga ttaattgtca     2460

aactagggct gcagggttca tagtgccact tttcctgcac tgccccatct cctgcccacc     2520

ctttcccagg catagacagt cagtgactta ccaaactcac aggagggaga aggcagaagc     2580

ttgagacaga cccgcgggac cgccgaactg cgaggggacg tggctagggc ggcttctttt     2640

atggtgcgcc ggccctcgga ggcagggcgc tcggggaggc ctagcggcca atctgcggtg     2700

gcaggaggcg gggccgaagg ccgtgcctga ccaatccgga gcacatagga gtctcagccc     2760

cccgccccaa agcaagggga agtcacgcgc ctgtagcgcc agcgtgttgt gaaatggggg     2820

cttggggggg ttggggccct gactagtcaa aacaaactcc cattgacgtc aatggggtgg     2880

agacttggaa atccccgtga gtcaaaccgc tatccacgcc cattgatgta ctgccaaaac     2940

cgcatcatca tggtaatagc gatgactaat acgtagatgt actgccaagt aggaaagtcc     3000

cataaggtca tgtactgggc ataatgccag gcgggccatt taccgtcatt gacgtcaata     3060

gggggcgtac ttggcatatg atacacttga tgtactgcca agtgggcagt ttaccgtaaa     3120

tactccaccc attgacgtca atggaaagtc cctattggcg ttactatggg aacatacgtc     3180

attattgacg tcaatgggcg ggggtcgttg ggcggtcagc caggcgggcc atttaccgta     3240

agttatgtaa cgcctgcagg ttaattaaga acatgtgagc aaaaggccag caaaaggcca     3300

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     3360

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     3420

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     3480

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta     3540

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     3600

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     3660

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     3720

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat     3780

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat     3840

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc     3900

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt     3960

ggaacgaaaa ctcacgttaa gggattttgg tcatggctag ttaattaaca tttaaatcag     4020

cggccgcaat aaaatatctt tattttcatt acatctgtgt gttggttttt tgtgtgaatc     4080

gtaactaaca tacgctctcc atcaaaacaa aacgaaacaa aacaaactag caaaataggc     4140

tgtccccagt gcaagtgcag gtgccagaac atttctctat cgaa                      4184


<210>  285
<211>  4836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPR149 pfuse-IgG1-Hole-Clone13A-VH-CKappa-CH2-CH3

<400>  285
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggaggttca gcttgtggaa tcagggggtg      660

ggctggtcca gcctggggga tctttgcgac tgagttgtgc tgcttcaggt ttcacattta      720

ctggctacag catgaactgg atgcggcaag cgccaggcaa agggcttgaa tgggtggcgg      780

agatcaatcc atccacagga ggcacgaccg ataaccagaa atttaaggcg aggtttacca      840

taagtagaga taactctaaa aacacgctct atctccaaat gaacagtctg cgggcggagg      900

atactgcagt ctactattgc gcccgcagcc gaggggacta ttgggggcag ggcactttgg      960

ttacagtgtc cagcgctagc gtggctgcac catctgtctt catcttcccg ccatctgatg     1020

agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc tatcccagag     1080

aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc caggagagtg     1140

tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg acgctgagca     1200

aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag ggcctgagct     1260

cgcccgtcac aaagagcttc aacaggggag agtgtgacaa aactcacaca tgcccaccgt     1320

gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg     1380

acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg     1440

aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga     1500

caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc     1560

tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc     1620

cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt     1680

gcaccctgcc cccatcccgg gacgagctga ccaagaacca ggtcagcctg tcctgcgcgg     1740

tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga     1800

acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctcgtcagca     1860

agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc     1920

atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg ggtaaatgag     1980

tcctagctgg ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat     2040

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     2100

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     2160

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggaatt     2220

aattctaaaa tacagcatag caaaacttta acctccaaat caagcctcta cttgaatcct     2280

tttctgaggg atgaataagg cataggcatc aggggctgtt gccaatgtgc attagctgtt     2340

tgcagcctca ccttctttca tggagtttaa gatatagtgt attttcccaa ggtttgaact     2400

agctcttcat ttctttatgt tttaaatgca ctgacctccc acattccctt tttagtaaaa     2460

tattcagaaa taatttaaat acatcattgc aatgaaaata aatgtttttt attaggcaga     2520

atccagatgc tcaaggccct tcataatatc ccccagttta gtagttggac ttagggaaca     2580

aaggaacctt taatagaaat tggacagcaa gaaagcgagc ttctagctta tcctcagtcc     2640

tgctcctctg ccacaaagtg cacgcagttg ccggccgggt cgcgcagggc gaactcccgc     2700

ccccacggct gctcgccgat ctcggtcatg gccggcccgg aggcgtcccg gaagttcgtg     2760

gacacgacct ccgaccactc ggcgtacagc tcgtccaggc cgcgcaccca cacccaggcc     2820

agggtgttgt ccggcaccac ctggtcctgg accgcgctga tgaacagggt cacgtcgtcc     2880

cggaccacac cggcgaagtc gtcctccacg aagtcccggg agaacccgag ccggtcggtc     2940

cagaactcga ccgctccggc gacgtcgcgc gcggtgagca ccggaacggc actggtcaac     3000

ttggccatga tggctcctcc tgtcaggaga ggaaagagaa gaaggttagt acaattgcta     3060

tagtgagttg tattatacta tgcagatata ctatgccaat gattaattgt caaactaggg     3120

ctgcagggtt catagtgcca cttttcctgc actgccccat ctcctgccca ccctttccca     3180

ggcatagaca gtcagtgact taccaaactc acaggaggga gaaggcagaa gcttgagaca     3240

gacccgcggg accgccgaac tgcgagggga cgtggctagg gcggcttctt ttatggtgcg     3300

ccggccctcg gaggcagggc gctcggggag gcctagcggc caatctgcgg tggcaggagg     3360

cggggccgaa ggccgtgcct gaccaatccg gagcacatag gagtctcagc cccccgcccc     3420

aaagcaaggg gaagtcacgc gcctgtagcg ccagcgtgtt gtgaaatggg ggcttggggg     3480

ggttggggcc ctgactagtc aaaacaaact cccattgacg tcaatggggt ggagacttgg     3540

aaatccccgt gagtcaaacc gctatccacg cccattgatg tactgccaaa accgcatcat     3600

catggtaata gcgatgacta atacgtagat gtactgccaa gtaggaaagt cccataaggt     3660

catgtactgg gcataatgcc aggcgggcca tttaccgtca ttgacgtcaa tagggggcgt     3720

acttggcata tgatacactt gatgtactgc caagtgggca gtttaccgta aatactccac     3780

ccattgacgt caatggaaag tccctattgg cgttactatg ggaacatacg tcattattga     3840

cgtcaatggg cgggggtcgt tgggcggtca gccaggcggg ccatttaccg taagttatgt     3900

aacgcctgca ggttaattaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3960

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     4020

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     4080

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     4140

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     4200

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     4260

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     4320

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4380

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     4440

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4500

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4560

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4620

aactcacgtt aagggatttt ggtcatggct agttaattaa catttaaatc agcggccgca     4680

ataaaatatc tttattttca ttacatctgt gtgttggttt tttgtgtgaa tcgtaactaa     4740

catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag gctgtcccca     4800

gtgcaagtgc aggtgccaga acatttctct atcgaa                               4836


<210>  286
<211>  4175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPR150 pFUSE-IgG-MB2-VL-CH1

<400>  286
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca      600

cttgtcacga attcagaaat agtattgacg cagtccccag ggactctgtc ccttagtccc      660

ggtggtcgcg ctacgctgag ttgccgagcc tcccaatcag tgtcaagttc ttatcttgct      720

tggtatcagc aaaagcctgg tcaggcccca aggcttctca tctatggcgc ttcatcaaga      780

gcgactggta ttccagaccg ctttagtggt tcaggaagtg gaaccgactt tacgctcact      840

atctcaagac tcgaacctga agactttgca gtttattact gtcagcagta tgggagcagc      900

ccacctacat tcggtcaagg cacgaaggtc gagattaaga gatcgagtgc tagcaccaag      960

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     1020

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc     1080

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     1140

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     1200

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgttag     1260

agggagcaag ctcgacatga taagatacat tgatgagttt ggacaaacca caactagaat     1320

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtgaaatt     1380

tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac     1440

aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag     1500

taaaacctct acaaatgtgg tatggaatta attctaaaat acagcatagc aaaactttaa     1560

cctccaaatc aagcctctac ttgaatcctt ttctgaggga tgaataaggc ataggcatca     1620

ggggctgttg ccaatgtgca ttagctgttt gcagcctcac cttctttcat ggagtttaag     1680

atatagtgta ttttcccaag gtttgaacta gctcttcatt tctttatgtt ttaaatgcac     1740

tgacctccca cattcccttt ttagtaaaat attcagaaat aatttaaata catcattgca     1800

atgaaaataa atgtttttta ttaggcagaa tccagatgct caaggccctt cataatatcc     1860

cccagtttag tagttggact tagggaacaa aggaaccttt aatagaaatt ggacagcaag     1920

aaagcgagct tctagcttta gttcctggtg tacttgaggg ggatgagttc ctcaatggtg     1980

gttttgacca gcttgccatt catctcaatg agcacaaagc agtcaggagc atagtcagag     2040

atgagctctc tgcacatgcc acaggggctg accaccctga tggatctgtc cacctcatca     2100

gagtaggggt gcctgacagc cacaatggtg tcaaagtcct tctgcccgtt gctcacagca     2160

gacccaatgg caatggcttc agcacagaca gtgaccctgc caatgtaggc ctcaatgtgg     2220

acagcagaga tgatctcccc agtcttggtc ctgatggccg ccccgacatg gtgcttgttg     2280

tcctcataga gcatggtgat cttctcagtg gcgacctcca ccagctccag atcctgctga     2340

gagatgttga aggtcttcat gatggctcct cctgtcagga gaggaaagag aagaaggtta     2400

gtacaattgc tatagtgagt tgtattatac tatgcttatg attaattgtc aaactagggc     2460

tgcagggttc atagtgccac ttttcctgca ctgccccatc tcctgcccac cctttcccag     2520

gcatagacag tcagtgactt accaaactca caggagggag aaggcagaag cttgagacag     2580

acccgcggga ccgccgaact gcgaggggac gtggctaggg cggcttcttt tatggtgcgc     2640

cggccctcgg aggcagggcg ctcggggagg cctagcggcc aatctgcggt ggcaggaggc     2700

ggggccgaag gccgtgcctg accaatccgg agcacatagg agtctcagcc ccccgcccca     2760

aagcaagggg aagtcacgcg cctgtagcgc cagcgtgttg tgaaatgggg gcttgggggg     2820

gttggggccc tgactagtca aaacaaactc ccattgacgt caatggggtg gagacttgga     2880

aatccccgtg agtcaaaccg ctatccacgc ccattgatgt actgccaaaa ccgcatcatc     2940

atggtaatag cgatgactaa tacgtagatg tactgccaag taggaaagtc ccataaggtc     3000

atgtactggg cataatgcca ggcgggccat ttaccgtcat tgacgtcaat agggggcgta     3060

cttggcatat gatacacttg atgtactgcc aagtgggcag tttaccgtaa atactccacc     3120

cattgacgtc aatggaaagt ccctattggc gttactatgg gaacatacgt cattattgac     3180

gtcaatgggc gggggtcgtt gggcggtcag ccaggcgggc catttaccgt aagttatgta     3240

acgcctgcag gttaattaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     3300

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     3360

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     3420

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     3480

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     3540

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     3600

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     3660

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     3720

cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct     3780

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     3840

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     3900

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa     3960

actcacgtta agggattttg gtcatggcta gttaattaac atttaaatca gcggccgcaa     4020

taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat cgtaactaac     4080

atacgctctc catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg ctgtccccag     4140

tgcaagtgca ggtgccagaa catttctcta tcgaa                                4175


<210>  287
<211>  4172
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPR151 pFUSE-IgG-PB3-VL-CH1

<400>  287
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca      600

cttgtcacga attcagacat tcagatgacc caatccccgt caagtctttc tgcatctgtt      660

ggagaccgag tcacaatcac atgtcaagca agtcaagata taagcaacta ccttaattgg      720

tatcagcaga aaccggggaa ggcccccaag ctgttgattt atgatgcgtc taatcttgag      780

acgggagtcc catcccgatt cagcgggtct gggtctggca cggatttcac atttacaata      840

agctcccttc aaccagagga cattgccaca tattactgtc agcaatacga taatttgccg      900

ctgacgtttg gaggtgggac taaggttgag attaaacggt cgagtgctag caccaagggc      960

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg     1020

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc     1080

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc     1140

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg     1200

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgttagagg     1260

gagcaagctc gacatgataa gatacattga tgagtttgga caaaccacaa ctagaatgca     1320

gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg tgaaatttgt     1380

gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat     1440

tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta aagcaagtaa     1500

aacctctaca aatgtggtat ggaattaatt ctaaaataca gcatagcaaa actttaacct     1560

ccaaatcaag cctctacttg aatccttttc tgagggatga ataaggcata ggcatcaggg     1620

gctgttgcca atgtgcatta gctgtttgca gcctcacctt ctttcatgga gtttaagata     1680

tagtgtattt tcccaaggtt tgaactagct cttcatttct ttatgtttta aatgcactga     1740

cctcccacat tcccttttta gtaaaatatt cagaaataat ttaaatacat cattgcaatg     1800

aaaataaatg ttttttatta ggcagaatcc agatgctcaa ggcccttcat aatatccccc     1860

agtttagtag ttggacttag ggaacaaagg aacctttaat agaaattgga cagcaagaaa     1920

gcgagcttct agctttagtt cctggtgtac ttgaggggga tgagttcctc aatggtggtt     1980

ttgaccagct tgccattcat ctcaatgagc acaaagcagt caggagcata gtcagagatg     2040

agctctctgc acatgccaca ggggctgacc accctgatgg atctgtccac ctcatcagag     2100

taggggtgcc tgacagccac aatggtgtca aagtccttct gcccgttgct cacagcagac     2160

ccaatggcaa tggcttcagc acagacagtg accctgccaa tgtaggcctc aatgtggaca     2220

gcagagatga tctccccagt cttggtcctg atggccgccc cgacatggtg cttgttgtcc     2280

tcatagagca tggtgatctt ctcagtggcg acctccacca gctccagatc ctgctgagag     2340

atgttgaagg tcttcatgat ggctcctcct gtcaggagag gaaagagaag aaggttagta     2400

caattgctat agtgagttgt attatactat gcttatgatt aattgtcaaa ctagggctgc     2460

agggttcata gtgccacttt tcctgcactg ccccatctcc tgcccaccct ttcccaggca     2520

tagacagtca gtgacttacc aaactcacag gagggagaag gcagaagctt gagacagacc     2580

cgcgggaccg ccgaactgcg aggggacgtg gctagggcgg cttcttttat ggtgcgccgg     2640

ccctcggagg cagggcgctc ggggaggcct agcggccaat ctgcggtggc aggaggcggg     2700

gccgaaggcc gtgcctgacc aatccggagc acataggagt ctcagccccc cgccccaaag     2760

caaggggaag tcacgcgcct gtagcgccag cgtgttgtga aatgggggct tgggggggtt     2820

ggggccctga ctagtcaaaa caaactccca ttgacgtcaa tggggtggag acttggaaat     2880

ccccgtgagt caaaccgcta tccacgccca ttgatgtact gccaaaaccg catcatcatg     2940

gtaatagcga tgactaatac gtagatgtac tgccaagtag gaaagtccca taaggtcatg     3000

tactgggcat aatgccaggc gggccattta ccgtcattga cgtcaatagg gggcgtactt     3060

ggcatatgat acacttgatg tactgccaag tgggcagttt accgtaaata ctccacccat     3120

tgacgtcaat ggaaagtccc tattggcgtt actatgggaa catacgtcat tattgacgtc     3180

aatgggcggg ggtcgttggg cggtcagcca ggcgggccat ttaccgtaag ttatgtaacg     3240

cctgcaggtt aattaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     3300

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     3360

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     3420

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     3480

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     3540

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     3600

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     3660

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     3720

agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg     3780

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     3840

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     3900

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     3960

cacgttaagg gattttggtc atggctagtt aattaacatt taaatcagcg gccgcaataa     4020

aatatcttta ttttcattac atctgtgtgt tggttttttg tgtgaatcgt aactaacata     4080

cgctctccat caaaacaaaa cgaaacaaaa caaactagca aaataggctg tccccagtgc     4140

aagtgcaggt gccagaacat ttctctatcg aa                                   4172


<210>  288
<211>  4848
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPR152 pfuse-IgG1-Hole-MB2-VH-CKappa-CH2-CH3

<400>  288
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggaagttca acttgttcaa agcggcgcag      660

aggtaaagaa acctggagag agtctcaaaa tcagttgcaa gggatcagga ttctcattta      720

cttcctactg gataggttgg gtccgacaaa tgcctgggaa gggtctcgaa tggatgggga      780

tcatatatcc tggagattca gacacaagat actccccatc tttccagggg caggttacta      840

ttagtgcgga caaaagtatc tcaacagcgt atctccagtg gtccagtctc aaggcgagcg      900

atactgcgat gtattattgt gcgaggggtg gttatgagga cgtgttcgat atttgggggc      960

agggcacgat ggtcacggta tcttccgcta gcgtggctgc accatctgtc ttcatcttcc     1020

cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact     1080

tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact     1140

cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc     1200

tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc     1260

agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgtgac aaaactcaca     1320

catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc ctcttccccc     1380

caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg     1440

acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc     1500

ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt gtggtcagcg     1560

tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca     1620

acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg cagccccgag     1680

aaccacaggt gtgcaccctg cccccatccc gggacgagct gaccaagaac caggtcagcc     1740

tgtcctgcgc ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg gagagcaatg     1800

ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac ggctccttct     1860

tcctcgtcag caagctcacc gtggacaaga gcaggtggca gcaggggaac gtcttctcat     1920

gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc tccctgtctc     1980

cgggtaaatg agtcctagct ggccagacat gataagatac attgatgagt ttggacaaac     2040

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt     2100

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     2160

gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg     2220

tggtatggaa ttaattctaa aatacagcat agcaaaactt taacctccaa atcaagcctc     2280

tacttgaatc cttttctgag ggatgaataa ggcataggca tcaggggctg ttgccaatgt     2340

gcattagctg tttgcagcct caccttcttt catggagttt aagatatagt gtattttccc     2400

aaggtttgaa ctagctcttc atttctttat gttttaaatg cactgacctc ccacattccc     2460

tttttagtaa aatattcaga aataatttaa atacatcatt gcaatgaaaa taaatgtttt     2520

ttattaggca gaatccagat gctcaaggcc cttcataata tcccccagtt tagtagttgg     2580

acttagggaa caaaggaacc tttaatagaa attggacagc aagaaagcga gcttctagct     2640

tatcctcagt cctgctcctc tgccacaaag tgcacgcagt tgccggccgg gtcgcgcagg     2700

gcgaactccc gcccccacgg ctgctcgccg atctcggtca tggccggccc ggaggcgtcc     2760

cggaagttcg tggacacgac ctccgaccac tcggcgtaca gctcgtccag gccgcgcacc     2820

cacacccagg ccagggtgtt gtccggcacc acctggtcct ggaccgcgct gatgaacagg     2880

gtcacgtcgt cccggaccac accggcgaag tcgtcctcca cgaagtcccg ggagaacccg     2940

agccggtcgg tccagaactc gaccgctccg gcgacgtcgc gcgcggtgag caccggaacg     3000

gcactggtca acttggccat gatggctcct cctgtcagga gaggaaagag aagaaggtta     3060

gtacaattgc tatagtgagt tgtattatac tatgcagata tactatgcca atgattaatt     3120

gtcaaactag ggctgcaggg ttcatagtgc cacttttcct gcactgcccc atctcctgcc     3180

caccctttcc caggcataga cagtcagtga cttaccaaac tcacaggagg gagaaggcag     3240

aagcttgaga cagacccgcg ggaccgccga actgcgaggg gacgtggcta gggcggcttc     3300

ttttatggtg cgccggccct cggaggcagg gcgctcgggg aggcctagcg gccaatctgc     3360

ggtggcagga ggcggggccg aaggccgtgc ctgaccaatc cggagcacat aggagtctca     3420

gccccccgcc ccaaagcaag gggaagtcac gcgcctgtag cgccagcgtg ttgtgaaatg     3480

ggggcttggg ggggttgggg ccctgactag tcaaaacaaa ctcccattga cgtcaatggg     3540

gtggagactt ggaaatcccc gtgagtcaaa ccgctatcca cgcccattga tgtactgcca     3600

aaaccgcatc atcatggtaa tagcgatgac taatacgtag atgtactgcc aagtaggaaa     3660

gtcccataag gtcatgtact gggcataatg ccaggcgggc catttaccgt cattgacgtc     3720

aatagggggc gtacttggca tatgatacac ttgatgtact gccaagtggg cagtttaccg     3780

taaatactcc acccattgac gtcaatggaa agtccctatt ggcgttacta tgggaacata     3840

cgtcattatt gacgtcaatg ggcgggggtc gttgggcggt cagccaggcg ggccatttac     3900

cgtaagttat gtaacgcctg caggttaatt aagaacatgt gagcaaaagg ccagcaaaag     3960

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     4020

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     4080

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     4140

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     4200

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     4260

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     4320

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     4380

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca     4440

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     4500

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     4560

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     4620

cagtggaacg aaaactcacg ttaagggatt ttggtcatgg ctagttaatt aacatttaaa     4680

tcagcggccg caataaaata tctttatttt cattacatct gtgtgttggt tttttgtgtg     4740

aatcgtaact aacatacgct ctccatcaaa acaaaacgaa acaaaacaaa ctagcaaaat     4800

aggctgtccc cagtgcaagt gcaggtgcca gaacatttct ctatcgaa                  4848


<210>  289
<211>  4848
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPR153 pfuse-IgG1-Hole-PB3-VH-CKappa-CH2-CH3

<400>  289
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggaggttca gcttgtagag tccggtggcg      660

gtctcgttca acccggcggg agcctgaggc tgtcttgcgc ggcttcagga ttcacattta      720

gttcctacgc catgtcctgg gtcagacaag caccaggaaa agggttggag tgggtgtcag      780

ttatctcagg ttccggaggc tcaaccagtt acgccgacag cgtcaaaggt cggttcacga      840

tctcccgaga caattcaaag aatacccttt atctccagat gaactctttg agggcggagg      900

acaccgccgt gtactattgt gctaaggaca aagcagtaga ggctttcgac atttgggggc      960

agggaactat ggtcaccgtg tccagtgcta gcgtggctgc accatctgtc ttcatcttcc     1020

cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact     1080

tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa tcgggtaact     1140

cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc     1200

tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc     1260

agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgtgac aaaactcaca     1320

catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc ctcttccccc     1380

caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg     1440

acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc     1500

ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt gtggtcagcg     1560

tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca     1620

acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg cagccccgag     1680

aaccacaggt gtgcaccctg cccccatccc gggacgagct gaccaagaac caggtcagcc     1740

tgtcctgcgc ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg gagagcaatg     1800

ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac ggctccttct     1860

tcctcgtcag caagctcacc gtggacaaga gcaggtggca gcaggggaac gtcttctcat     1920

gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc tccctgtctc     1980

cgggtaaatg agtcctagct ggccagacat gataagatac attgatgagt ttggacaaac     2040

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt     2100

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     2160

gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg     2220

tggtatggaa ttaattctaa aatacagcat agcaaaactt taacctccaa atcaagcctc     2280

tacttgaatc cttttctgag ggatgaataa ggcataggca tcaggggctg ttgccaatgt     2340

gcattagctg tttgcagcct caccttcttt catggagttt aagatatagt gtattttccc     2400

aaggtttgaa ctagctcttc atttctttat gttttaaatg cactgacctc ccacattccc     2460

tttttagtaa aatattcaga aataatttaa atacatcatt gcaatgaaaa taaatgtttt     2520

ttattaggca gaatccagat gctcaaggcc cttcataata tcccccagtt tagtagttgg     2580

acttagggaa caaaggaacc tttaatagaa attggacagc aagaaagcga gcttctagct     2640

tatcctcagt cctgctcctc tgccacaaag tgcacgcagt tgccggccgg gtcgcgcagg     2700

gcgaactccc gcccccacgg ctgctcgccg atctcggtca tggccggccc ggaggcgtcc     2760

cggaagttcg tggacacgac ctccgaccac tcggcgtaca gctcgtccag gccgcgcacc     2820

cacacccagg ccagggtgtt gtccggcacc acctggtcct ggaccgcgct gatgaacagg     2880

gtcacgtcgt cccggaccac accggcgaag tcgtcctcca cgaagtcccg ggagaacccg     2940

agccggtcgg tccagaactc gaccgctccg gcgacgtcgc gcgcggtgag caccggaacg     3000

gcactggtca acttggccat gatggctcct cctgtcagga gaggaaagag aagaaggtta     3060

gtacaattgc tatagtgagt tgtattatac tatgcagata tactatgcca atgattaatt     3120

gtcaaactag ggctgcaggg ttcatagtgc cacttttcct gcactgcccc atctcctgcc     3180

caccctttcc caggcataga cagtcagtga cttaccaaac tcacaggagg gagaaggcag     3240

aagcttgaga cagacccgcg ggaccgccga actgcgaggg gacgtggcta gggcggcttc     3300

ttttatggtg cgccggccct cggaggcagg gcgctcgggg aggcctagcg gccaatctgc     3360

ggtggcagga ggcggggccg aaggccgtgc ctgaccaatc cggagcacat aggagtctca     3420

gccccccgcc ccaaagcaag gggaagtcac gcgcctgtag cgccagcgtg ttgtgaaatg     3480

ggggcttggg ggggttgggg ccctgactag tcaaaacaaa ctcccattga cgtcaatggg     3540

gtggagactt ggaaatcccc gtgagtcaaa ccgctatcca cgcccattga tgtactgcca     3600

aaaccgcatc atcatggtaa tagcgatgac taatacgtag atgtactgcc aagtaggaaa     3660

gtcccataag gtcatgtact gggcataatg ccaggcgggc catttaccgt cattgacgtc     3720

aatagggggc gtacttggca tatgatacac ttgatgtact gccaagtggg cagtttaccg     3780

taaatactcc acccattgac gtcaatggaa agtccctatt ggcgttacta tgggaacata     3840

cgtcattatt gacgtcaatg ggcgggggtc gttgggcggt cagccaggcg ggccatttac     3900

cgtaagttat gtaacgcctg caggttaatt aagaacatgt gagcaaaagg ccagcaaaag     3960

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     4020

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     4080

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     4140

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     4200

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     4260

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     4320

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     4380

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca     4440

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     4500

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     4560

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     4620

cagtggaacg aaaactcacg ttaagggatt ttggtcatgg ctagttaatt aacatttaaa     4680

tcagcggccg caataaaata tctttatttt cattacatct gtgtgttggt tttttgtgtg     4740

aatcgtaact aacatacgct ctccatcaaa acaaaacgaa acaaaacaaa ctagcaaaat     4800

aggctgtccc cagtgcaagt gcaggtgcca gaacatttct ctatcgaa                  4848


<210>  290
<211>  4836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPR154 pfuse-IgG1-Knob-MB.02-VH-CH1-CH2-CH3

<400>  290
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggaagttca acttgttcaa agcggcgcag      660

aggtaaagaa acctggagag agtctcaaaa tcagttgcaa gggatcagga ttctcattta      720

cttcctactg gataggttgg gtccgacaaa tgcctgggaa gggtctcgaa tggatgggga      780

tcatatatcc tggagattca gacacaagat actccccatc tttccagggg caggttacta      840

ttagtgcgga caaaagtatc tcaacagcgt atctccagtg gtccagtctc aaggcgagcg      900

atactgcgat gtattattgt gcgaggggtg gttatgagga cgtgttcgat atttgggggc      960

agggcacgat ggtcacggta tcttccgcta gcaccaaggg cccatcggtc ttccccctgg     1020

caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg gtcaaggact     1080

acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca     1140

ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg gtgaccgtgc     1200

cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag cccagcaaca     1260

ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca tgcccaccgt     1320

gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg     1380

acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg     1440

aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga     1500

caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc     1560

tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc     1620

cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt     1680

acaccctgcc accatgccgg gacgagctga ccaagaacca ggtcagcctg tggtgcctgg     1740

tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga     1800

acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca     1860

agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc     1920

atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg ggtaaatgag     1980

tcctagctgg ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat     2040

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     2100

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     2160

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggaatt     2220

aattctaaaa tacagcatag caaaacttta acctccaaat caagcctcta cttgaatcct     2280

tttctgaggg atgaataagg cataggcatc aggggctgtt gccaatgtgc attagctgtt     2340

tgcagcctca ccttctttca tggagtttaa gatatagtgt attttcccaa ggtttgaact     2400

agctcttcat ttctttatgt tttaaatgca ctgacctccc acattccctt tttagtaaaa     2460

tattcagaaa taatttaaat acatcattgc aatgaaaata aatgtttttt attaggcaga     2520

atccagatgc tcaaggccct tcataatatc ccccagttta gtagttggac ttagggaaca     2580

aaggaacctt taatagaaat tggacagcaa gaaagcgagc ttctagctta tcctcagtcc     2640

tgctcctctg ccacaaagtg cacgcagttg ccggccgggt cgcgcagggc gaactcccgc     2700

ccccacggct gctcgccgat ctcggtcatg gccggcccgg aggcgtcccg gaagttcgtg     2760

gacacgacct ccgaccactc ggcgtacagc tcgtccaggc cgcgcaccca cacccaggcc     2820

agggtgttgt ccggcaccac ctggtcctgg accgcgctga tgaacagggt cacgtcgtcc     2880

cggaccacac cggcgaagtc gtcctccacg aagtcccggg agaacccgag ccggtcggtc     2940

cagaactcga ccgctccggc gacgtcgcgc gcggtgagca ccggaacggc actggtcaac     3000

ttggccatga tggctcctcc tgtcaggaga ggaaagagaa gaaggttagt acaattgcta     3060

tagtgagttg tattatacta tgcagatata ctatgccaat gattaattgt caaactaggg     3120

ctgcagggtt catagtgcca cttttcctgc actgccccat ctcctgccca ccctttccca     3180

ggcatagaca gtcagtgact taccaaactc acaggaggga gaaggcagaa gcttgagaca     3240

gacccgcggg accgccgaac tgcgagggga cgtggctagg gcggcttctt ttatggtgcg     3300

ccggccctcg gaggcagggc gctcggggag gcctagcggc caatctgcgg tggcaggagg     3360

cggggccgaa ggccgtgcct gaccaatccg gagcacatag gagtctcagc cccccgcccc     3420

aaagcaaggg gaagtcacgc gcctgtagcg ccagcgtgtt gtgaaatggg ggcttggggg     3480

ggttggggcc ctgactagtc aaaacaaact cccattgacg tcaatggggt ggagacttgg     3540

aaatccccgt gagtcaaacc gctatccacg cccattgatg tactgccaaa accgcatcat     3600

catggtaata gcgatgacta atacgtagat gtactgccaa gtaggaaagt cccataaggt     3660

catgtactgg gcataatgcc aggcgggcca tttaccgtca ttgacgtcaa tagggggcgt     3720

acttggcata tgatacactt gatgtactgc caagtgggca gtttaccgta aatactccac     3780

ccattgacgt caatggaaag tccctattgg cgttactatg ggaacatacg tcattattga     3840

cgtcaatggg cgggggtcgt tgggcggtca gccaggcggg ccatttaccg taagttatgt     3900

aacgcctgca ggttaattaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3960

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     4020

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     4080

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     4140

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     4200

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     4260

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     4320

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4380

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     4440

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4500

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4560

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4620

aactcacgtt aagggatttt ggtcatggct agttaattaa catttaaatc agcggccgca     4680

ataaaatatc tttattttca ttacatctgt gtgttggttt tttgtgtgaa tcgtaactaa     4740

catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag gctgtcccca     4800

gtgcaagtgc aggtgccaga acatttctct atcgaa                               4836


