                         SEQUENCE LISTING

<110>  Cellibre, Inc.
 
<120>  ENGINEERED CELLS, ENZYMES, AND METHODS FOR PRODUCING CANNABINOIDS

<130>  CELB-003-WO1

<140>  PCT/US2022/029326
<141>  2022-05-13

<150>  63/188,648
<151>  2021-05-14

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  395
<212>  PRT
<213>  Unknown

<220>
<223>  MPT1 (membrane-bound prenyltransferase)

<400>  1

Met Gly Leu Ser Ser Val Cys Thr Phe Ser Phe Gln Thr Asn Tyr His 
1               5                   10                  15      


Thr Leu Leu Asn Pro His Asn Asn Asn Pro Lys Thr Ser Leu Leu Cys 
            20                  25                  30          


Tyr Arg His Pro Lys Thr Pro Ile Lys Tyr Ser Tyr Asn Asn Phe Pro 
        35                  40                  45              


Ser Lys His Cys Ser Thr Lys Ser Phe His Leu Gln Asn Lys Cys Ser 
    50                  55                  60                  


Glu Ser Leu Ser Ile Ala Lys Asn Ser Ile Arg Ala Ala Thr Thr Asn 
65                  70                  75                  80  


Gln Thr Glu Pro Pro Glu Ser Asp Asn His Ser Val Ala Thr Lys Ile 
                85                  90                  95      


Leu Asn Phe Gly Lys Ala Cys Trp Lys Leu Gln Arg Pro Tyr Thr Ile 
            100                 105                 110         


Ile Ala Phe Thr Ser Cys Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu 
        115                 120                 125             


His Asn Thr Asn Leu Ile Ser Trp Ser Leu Met Phe Lys Ala Phe Phe 
    130                 135                 140                 


Phe Leu Val Ala Val Leu Cys Ile Ala Ser Phe Thr Thr Thr Ile Asn 
145                 150                 155                 160 


Gln Ile Tyr Asp Leu His Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro 
                165                 170                 175     


Leu Ala Ser Gly Glu Ile Ser Val Asn Thr Ala Trp Ile Met Ser Ile 
            180                 185                 190         


Ile Val Ala Leu Phe Gly Leu Ile Ile Thr Ile Lys Met Lys Gly Gly 
        195                 200                 205             


Pro Leu Tyr Ile Phe Gly Tyr Cys Phe Gly Ile Phe Gly Gly Ile Val 
    210                 215                 220                 


Tyr Ser Val Pro Pro Phe Arg Trp Lys Gln Asn Pro Ser Thr Ala Phe 
225                 230                 235                 240 


Leu Leu Asn Phe Leu Ala His Ile Ile Thr Asn Phe Thr Phe Tyr Tyr 
                245                 250                 255     


Ala Ser Arg Ala Ala Leu Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe 
            260                 265                 270         


Thr Phe Leu Leu Ala Phe Met Lys Ser Met Gly Ser Ala Leu Ala Leu 
        275                 280                 285             


Ile Lys Asp Ala Ser Asp Val Glu Gly Asp Thr Lys Phe Gly Ile Ser 
    290                 295                 300                 


Thr Leu Ala Ser Lys Tyr Gly Ser Arg Asn Leu Thr Leu Phe Cys Ser 
305                 310                 315                 320 


Gly Ile Val Leu Leu Ser Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile 
                325                 330                 335     


Trp Pro Gln Ala Phe Asn Ser Asn Val Met Leu Leu Ser His Ala Ile 
            340                 345                 350         


Leu Ala Phe Trp Leu Ile Leu Gln Thr Arg Asp Phe Ala Leu Thr Asn 
        355                 360                 365             


Tyr Asp Pro Glu Ala Gly Arg Arg Phe Tyr Glu Phe Met Trp Lys Leu 
    370                 375                 380                 


Tyr Tyr Ala Glu Tyr Leu Val Tyr Val Phe Ile 
385                 390                 395 


<210>  2
<211>  309
<212>  PRT
<213>  Unknown

<220>
<223>  MPT4 (membrane-bound prenyltransferase)

<400>  2

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Leu Val Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys 
                245                 250                 255     


Ser Asn Ile Met Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  3

<400>  3
000

<210>  4
<211>  344
<212>  PRT
<213>  Unknown

<220>
<223>  GPS1.1 (geranyl diphosphate synthase)

<400>  4

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys 
            340                 


<210>  5
<211>  371
<212>  PRT
<213>  Unknown

<220>
<223>  GPS2 (geranyl diphosphate synthase)

<400>  5

Met Lys Asp Val Ser Leu Ser Ser Phe Asp Ala His Asp Leu Asp Leu 
1               5                   10                  15      


Asp Lys Phe Pro Glu Val Val Arg Asp Arg Leu Thr Gln Phe Leu Asp 
            20                  25                  30          


Ala Gln Glu Leu Thr Ile Ala Asp Ile Gly Ala Pro Val Thr Asp Ala 
        35                  40                  45              


Val Ala His Leu Arg Ser Phe Val Leu Asn Gly Gly Lys Arg Ile Arg 
    50                  55                  60                  


Pro Leu Tyr Ala Trp Ala Gly Phe Leu Ala Ala Gln Gly His Lys Asn 
65                  70                  75                  80  


Ser Ser Glu Lys Leu Glu Ser Val Leu Asp Ala Ala Ala Ser Leu Glu 
                85                  90                  95      


Phe Ile Gln Ala Cys Ala Leu Ile His Asp Asp Ile Ile Asp Ser Ser 
            100                 105                 110         


Asp Thr Arg Arg Gly Ala Pro Thr Val His Arg Ala Val Glu Ala Asp 
        115                 120                 125             


His Arg Ala Asn Asn Phe Glu Gly Asp Pro Glu His Phe Gly Val Ser 
    130                 135                 140                 


Val Ser Ile Leu Ala Gly Asp Met Ala Leu Val Trp Ala Glu Asp Met 
145                 150                 155                 160 


Leu Gln Asp Ser Gly Leu Ser Ala Glu Ala Leu Ala Arg Thr Arg Asp 
                165                 170                 175     


Ala Trp Arg Gly Met Arg Thr Glu Val Ile Gly Gly Gln Leu Leu Asp 
            180                 185                 190         


Ile Tyr Leu Glu Ser His Ala Asn Glu Ser Val Glu Leu Ala Asp Ser 
        195                 200                 205             


Val Asn Arg Phe Lys Thr Ala Ala Tyr Thr Ile Ala Arg Pro Leu His 
    210                 215                 220                 


Leu Gly Ala Ser Ile Ala Gly Gly Ser Pro Gln Leu Ile Asp Ala Leu 
225                 230                 235                 240 


Leu His Tyr Gly His Asp Ile Gly Ile Ala Phe Gln Leu Arg Asp Asp 
                245                 250                 255     


Leu Leu Gly Val Phe Gly Asp Pro Ala Ile Thr Gly Lys Pro Ala Gly 
            260                 265                 270         


Asp Asp Ile Arg Glu Gly Lys Arg Thr Val Leu Leu Ala Leu Ala Leu 
        275                 280                 285             


Gln Arg Ala Asp Lys Gln Ser Pro Glu Ala Ala Thr Ala Ile Arg Ala 
    290                 295                 300                 


Gly Val Gly Lys Val Thr Ser Pro Glu Asp Ile Ala Val Ile Thr Glu 
305                 310                 315                 320 


His Ile Arg Ala Thr Gly Ala Glu Glu Glu Val Glu Gln Arg Ile Ser 
                325                 330                 335     


Gln Leu Thr Glu Ser Gly Leu Ala His Leu Asp Asp Val Asp Ile Pro 
            340                 345                 350         


Asp Glu Val Arg Ala Gln Leu Arg Ala Leu Ala Ile Arg Ser Thr Glu 
        355                 360                 365             


Arg Arg Met 
    370     


<210>  6
<211>  310
<212>  PRT
<213>  Unknown

<220>
<223>  GPS3 (geranyl diphosphate synthase)

<400>  6

Met Gln Leu Leu Asn Pro Pro Gln Lys Gly Lys Lys Ala Val Glu Phe 
1               5                   10                  15      


Asp Phe Asn Lys Tyr Met Asp Ser Lys Ala Met Thr Val Asn Glu Ala 
            20                  25                  30          


Leu Asn Lys Ala Ile Pro Leu Arg Tyr Pro Gln Lys Ile Tyr Glu Ser 
        35                  40                  45              


Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg Pro Val Leu 
    50                  55                  60                  


Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Thr Glu Glu Leu Ala Ile 
65                  70                  75                  80  


Pro Thr Ala Cys Ala Ile Glu Met Ile His Thr Met Ser Leu Met His 
                85                  90                  95      


Asp Asp Leu Pro Cys Ile Asp Asn Asp Asp Leu Arg Arg Gly Lys Pro 
            100                 105                 110         


Thr Asn His Lys Ile Phe Gly Glu Asp Thr Ala Val Thr Ala Gly Asn 
        115                 120                 125             


Ala Leu His Ser Tyr Ala Phe Glu His Ile Ala Val Ser Thr Ser Lys 
    130                 135                 140                 


Thr Val Gly Ala Asp Arg Ile Leu Arg Met Val Ser Glu Leu Gly Arg 
145                 150                 155                 160 


Ala Thr Gly Ser Glu Gly Val Met Gly Gly Gln Met Val Asp Ile Ala 
                165                 170                 175     


Ser Glu Gly Asp Pro Ser Ile Asp Leu Gln Thr Leu Glu Trp Ile His 
            180                 185                 190         


Ile His Lys Thr Ala Met Leu Leu Glu Cys Ser Val Val Cys Gly Ala 
        195                 200                 205             


Ile Ile Gly Gly Ala Ser Glu Ile Val Ile Glu Arg Ala Arg Arg Tyr 
    210                 215                 220                 


Ala Arg Cys Val Gly Leu Leu Phe Gln Val Val Asp Asp Ile Leu Asp 
225                 230                 235                 240 


Val Thr Lys Ser Ser Asp Glu Leu Gly Lys Thr Ala Gly Lys Asp Leu 
                245                 250                 255     


Ile Ser Asp Lys Ala Thr Tyr Pro Lys Leu Met Gly Leu Glu Lys Ala 
            260                 265                 270         


Lys Glu Phe Ser Asp Glu Leu Leu Asn Arg Ala Lys Gly Glu Leu Ser 
        275                 280                 285             


Cys Phe Asp Pro Val Lys Ala Ala Pro Leu Leu Gly Leu Ala Asp Tyr 
    290                 295                 300                 


Val Ala Phe Arg Gln Asn 
305                 310 


<210>  7
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  F1 linker

<400>  7

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala Glu Ala Ala Ala Lys Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser 
    


<210>  8
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  F2 linker

<400>  8

Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser 
            20                  25                  


<210>  9
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  F3 linker

<400>  9

Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly Gly Ser Pro Gly 
            20                  25                  30          


Pro Gly Pro Gly Gly Gly Ser 
        35                  


<210>  10
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  F4 linker

<400>  10

Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser 
1               5                   10                  15      


Ser Ser Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser 
            20                  25                  30          


Ser Ser Ser Gly 
        35      


<210>  11
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  F5 linker

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  12
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  F6 linker

<400>  12

Gly Gly Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Lys Gly Gly 
            


<210>  13
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  F7 linker

<400>  13

Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Pro Ala 
1               5                   10                  15      


Pro Ala Pro Ala Gly 
            20      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  F8 linker

<400>  14

Gly Thr Pro Thr Pro Thr Pro Thr Pro Thr Gly 
1               5                   10      


<210>  15
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  F9 linker

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  16
<211>  692
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-MPT4, geranyl diphosphate synthase, membrane-bound 
       prenyltransferase fusion protein

<400>  16

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys 
385                 390                 395                 400 


Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile Ala 
                405                 410                 415     


Cys Gly Leu Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser 
            420                 425                 430         


Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser 
        435                 440                 445             


Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile 
    450                 455                 460                 


Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser 
465                 470                 475                 480 


Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu 
                485                 490                 495     


Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr 
            500                 505                 510         


Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg 
        515                 520                 525             


Trp Lys Gln Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His 
    530                 535                 540                 


Val Gly Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly 
545                 550                 555                 560 


Leu Pro Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met 
                565                 570                 575     


Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile 
            580                 585                 590         


Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly 
        595                 600                 605             


Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr 
    610                 615                 620                 


Leu Val Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser 
625                 630                 635                 640 


Asn Ile Met Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe 
                645                 650                 655     


Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg 
            660                 665                 670         


Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val 
        675                 680                 685             


Tyr Val Phe Ile 
    690         


<210>  17
<211>  668
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F5-MPT4, geranyl diphosphate synthase, membrane-bound 
       prenyltransferase fusion protein

<400>  17

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser Ile Ala Thr Lys 
        355                 360                 365             


Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro Tyr Val 
    370                 375                 380                 


Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Arg Glu Leu 
385                 390                 395                 400 


Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp Lys Ala Phe 
                405                 410                 415     


Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala Ile Met 
            420                 425                 430         


Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro Asp Leu 
        435                 440                 445             


Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile Leu Ser 
    450                 455                 460                 


Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu Lys Ser 
465                 470                 475                 480 


Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala Gly Phe 
                485                 490                 495     


Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe Thr Asn 
            500                 505                 510         


Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr Ser Tyr 
        515                 520                 525             


Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg Pro Ala 
    530                 535                 540                 


Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr Ile Ala 
545                 550                 555                 560 


Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr Gly Val 
                565                 570                 575     


Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe Val Val 
            580                 585                 590         


Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile Gly Ile 
        595                 600                 605             


Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser His Ala 
    610                 615                 620                 


Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala Leu Ala 
625                 630                 635                 640 


Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile Trp Leu 
                645                 650                 655     


Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
            660                 665             


<210>  18
<211>  683
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F9-MPT4, geranyl diphosphate synthase, membrane-bound 
       prenyltransferase fusion protein

<400>  18

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser Ile Ala Thr Lys Ile 
    370                 375                 380                 


Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro Tyr Val Val 
385                 390                 395                 400 


Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Arg Glu Leu Phe 
                405                 410                 415     


Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp Lys Ala Phe Phe 
            420                 425                 430         


Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala Ile Met Asn 
        435                 440                 445             


Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro 
    450                 455                 460                 


Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile 
465                 470                 475                 480 


Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu Lys Ser Ala 
                485                 490                 495     


Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala 
            500                 505                 510         


Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe Thr Asn Phe 
        515                 520                 525             


Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr Ser Tyr Ser 
    530                 535                 540                 


Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg Pro Ala Phe 
545                 550                 555                 560 


Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr Ile Ala Phe 
                565                 570                 575     


Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser 
            580                 585                 590         


Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe Val Val Ser 
        595                 600                 605             


Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile Gly Ile Ile 
    610                 615                 620                 


Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser His Ala Ile 
625                 630                 635                 640 


Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn 
                645                 650                 655     


Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu 
            660                 665                 670         


Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
        675                 680             


<210>  19
<211>  705
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F10-MPT4, geranyl diphosphate synthase, membrane-bound 
       prenyltransferase fusion protein

<400>  19

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 
        355                 360                 365             


Lys Ala Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Glu 
    370                 375                 380                 


Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly Met Ser Asp Asn 
385                 390                 395                 400 


Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu 
                405                 410                 415     


Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu 
            420                 425                 430         


Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu 
        435                 440                 445             


Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe 
    450                 455                 460                 


Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile 
465                 470                 475                 480 


Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr 
                485                 490                 495     


Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr 
            500                 505                 510         


Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly 
        515                 520                 525             


Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln 
    530                 535                 540                 


Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu 
545                 550                 555                 560 


Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe 
                565                 570                 575     


Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met 
            580                 585                 590         


Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp 
        595                 600                 605             


Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn 
    610                 615                 620                 


Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser 
625                 630                 635                 640 


Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met 
                645                 650                 655     


Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg 
            660                 665                 670         


Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe 
        675                 680                 685             


Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe 
    690                 695                 700                 


Ile 
705 


<210>  20
<211>  658
<212>  PRT
<213>  Artificial

<220>
<223>  GPS3-F11-MPT4, geranyl diphosphate synthase, membrane-bound 
       prenyltransferase fusion protein

<400>  20

Met Gln Leu Leu Asn Pro Pro Gln Lys Gly Lys Lys Ala Val Glu Phe 
1               5                   10                  15      


Asp Phe Asn Lys Tyr Met Asp Ser Lys Ala Met Thr Val Asn Glu Ala 
            20                  25                  30          


Leu Asn Lys Ala Ile Pro Leu Arg Tyr Pro Gln Lys Ile Tyr Glu Ser 
        35                  40                  45              


Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg Pro Val Leu 
    50                  55                  60                  


Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Thr Glu Glu Leu Ala Ile 
65                  70                  75                  80  


Pro Thr Ala Cys Ala Ile Glu Met Ile His Thr Met Ser Leu Met His 
                85                  90                  95      


Asp Asp Leu Pro Cys Ile Asp Asn Asp Asp Leu Arg Arg Gly Lys Pro 
            100                 105                 110         


Thr Asn His Lys Ile Phe Gly Glu Asp Thr Ala Val Thr Ala Gly Asn 
        115                 120                 125             


Ala Leu His Ser Tyr Ala Phe Glu His Ile Ala Val Ser Thr Ser Lys 
    130                 135                 140                 


Thr Val Gly Ala Asp Arg Ile Leu Arg Met Val Ser Glu Leu Gly Arg 
145                 150                 155                 160 


Ala Thr Gly Ser Glu Gly Val Met Gly Gly Gln Met Val Asp Ile Ala 
                165                 170                 175     


Ser Glu Gly Asp Pro Ser Ile Asp Leu Gln Thr Leu Glu Trp Ile His 
            180                 185                 190         


Ile His Lys Thr Ala Met Leu Leu Glu Cys Ser Val Val Cys Gly Ala 
        195                 200                 205             


Ile Ile Gly Gly Ala Ser Glu Ile Val Ile Glu Arg Ala Arg Arg Tyr 
    210                 215                 220                 


Ala Arg Cys Val Gly Leu Leu Phe Gln Val Val Asp Asp Ile Leu Asp 
225                 230                 235                 240 


Val Thr Lys Ser Ser Asp Glu Leu Gly Lys Thr Ala Gly Lys Asp Leu 
                245                 250                 255     


Ile Ser Asp Lys Ala Thr Tyr Pro Lys Leu Met Gly Leu Glu Lys Ala 
            260                 265                 270         


Lys Glu Phe Ser Asp Glu Leu Leu Asn Arg Ala Lys Gly Glu Leu Ser 
        275                 280                 285             


Cys Phe Asp Pro Val Lys Ala Ala Pro Leu Leu Gly Leu Ala Asp Tyr 
    290                 295                 300                 


Val Ala Phe Arg Gln Asn Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala 
305                 310                 315                 320 


Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                325                 330                 335     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp 
            340                 345                 350         


Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys 
        355                 360                 365             


Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile Ala Cys Gly 
    370                 375                 380                 


Leu Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly 
385                 390                 395                 400 


Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn 
                405                 410                 415     


Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg 
            420                 425                 430         


Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu 
        435                 440                 445             


Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val 
    450                 455                 460                 


Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe 
465                 470                 475                 480 


Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys 
                485                 490                 495     


Gln Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly 
            500                 505                 510         


Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro 
        515                 520                 525             


Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val 
    530                 535                 540                 


Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly 
545                 550                 555                 560 


Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg 
                565                 570                 575     


Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val 
            580                 585                 590         


Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile 
        595                 600                 605             


Met Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr 
    610                 615                 620                 


Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe 
625                 630                 635                 640 


Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val 
                645                 650                 655     


Phe Ile 
        


<210>  21
<211>  719
<212>  PRT
<213>  Artificial

<220>
<223>  GPS2-F11-MPT4, geranyl diphosphate synthase, membrane-bound 
       prenyltransferase fusion protein

<400>  21

Met Lys Asp Val Ser Leu Ser Ser Phe Asp Ala His Asp Leu Asp Leu 
1               5                   10                  15      


Asp Lys Phe Pro Glu Val Val Arg Asp Arg Leu Thr Gln Phe Leu Asp 
            20                  25                  30          


Ala Gln Glu Leu Thr Ile Ala Asp Ile Gly Ala Pro Val Thr Asp Ala 
        35                  40                  45              


Val Ala His Leu Arg Ser Phe Val Leu Asn Gly Gly Lys Arg Ile Arg 
    50                  55                  60                  


Pro Leu Tyr Ala Trp Ala Gly Phe Leu Ala Ala Gln Gly His Lys Asn 
65                  70                  75                  80  


Ser Ser Glu Lys Leu Glu Ser Val Leu Asp Ala Ala Ala Ser Leu Glu 
                85                  90                  95      


Phe Ile Gln Ala Cys Ala Leu Ile His Asp Asp Ile Ile Asp Ser Ser 
            100                 105                 110         


Asp Thr Arg Arg Gly Ala Pro Thr Val His Arg Ala Val Glu Ala Asp 
        115                 120                 125             


His Arg Ala Asn Asn Phe Glu Gly Asp Pro Glu His Phe Gly Val Ser 
    130                 135                 140                 


Val Ser Ile Leu Ala Gly Asp Met Ala Leu Val Trp Ala Glu Asp Met 
145                 150                 155                 160 


Leu Gln Asp Ser Gly Leu Ser Ala Glu Ala Leu Ala Arg Thr Arg Asp 
                165                 170                 175     


Ala Trp Arg Gly Met Arg Thr Glu Val Ile Gly Gly Gln Leu Leu Asp 
            180                 185                 190         


Ile Tyr Leu Glu Ser His Ala Asn Glu Ser Val Glu Leu Ala Asp Ser 
        195                 200                 205             


Val Asn Arg Phe Lys Thr Ala Ala Tyr Thr Ile Ala Arg Pro Leu His 
    210                 215                 220                 


Leu Gly Ala Ser Ile Ala Gly Gly Ser Pro Gln Leu Ile Asp Ala Leu 
225                 230                 235                 240 


Leu His Tyr Gly His Asp Ile Gly Ile Ala Phe Gln Leu Arg Asp Asp 
                245                 250                 255     


Leu Leu Gly Val Phe Gly Asp Pro Ala Ile Thr Gly Lys Pro Ala Gly 
            260                 265                 270         


Asp Asp Ile Arg Glu Gly Lys Arg Thr Val Leu Leu Ala Leu Ala Leu 
        275                 280                 285             


Gln Arg Ala Asp Lys Gln Ser Pro Glu Ala Ala Thr Ala Ile Arg Ala 
    290                 295                 300                 


Gly Val Gly Lys Val Thr Ser Pro Glu Asp Ile Ala Val Ile Thr Glu 
305                 310                 315                 320 


His Ile Arg Ala Thr Gly Ala Glu Glu Glu Val Glu Gln Arg Ile Ser 
                325                 330                 335     


Gln Leu Thr Glu Ser Gly Leu Ala His Leu Asp Asp Val Asp Ile Pro 
            340                 345                 350         


Asp Glu Val Arg Ala Gln Leu Arg Ala Leu Ala Ile Arg Ser Thr Glu 
        355                 360                 365             


Arg Arg Met Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
    370                 375                 380                 


Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser Ile 
                405                 410                 415     


Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg 
            420                 425                 430         


Pro Tyr Val Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly 
        435                 440                 445             


Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp 
    450                 455                 460                 


Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala 
465                 470                 475                 480 


Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys 
                485                 490                 495     


Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp 
            500                 505                 510         


Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys 
        515                 520                 525             


Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe 
    530                 535                 540                 


Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro 
545                 550                 555                 560 


Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe 
                565                 570                 575     


Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp 
            580                 585                 590         


Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met 
        595                 600                 605             


Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys 
    610                 615                 620                 


Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr 
625                 630                 635                 640 


Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser 
                645                 650                 655     


Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu 
            660                 665                 670         


Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu 
        675                 680                 685             


Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe 
    690                 695                 700                 


Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
705                 710                 715                 


<210>  22
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21 (recombinant membrane-bound prenyltransferase)

<400>  22

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  23
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT26 (recombinant membrane-bound prenyltransferase)

<400>  23

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Trp Leu Ile 
            260                 265                 270         


Leu Gln Thr Arg Asp Phe Ala Leu Thr Asn Tyr Asp Pro Glu Ala Gly 
        275                 280                 285             


Arg Arg Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  24
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT31 (recombinant membrane-bound prenyltransferase)

<400>  24

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Ala 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Arg Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Leu His 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Ala Ser Gly Glu Ile 
                85                  90                  95      


Ser Val Asn Thr Ala Trp Ile Met Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Leu Val Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys 
                245                 250                 255     


Ser Asn Ile Met Ile Leu Ser His Ala Ile Leu Ala Phe Trp Leu Ile 
            260                 265                 270         


Leu Gln Thr Arg Asp Phe Ala Leu Thr Asn Tyr Asp Pro Glu Ala Gly 
        275                 280                 285             


Arg Arg Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Leu 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  25
<211>  692
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-MPT21, geranyl diphosphate synthase, recombinant 
       membrane-bound prenyltransferase fusion protein

<400>  25

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys 
385                 390                 395                 400 


Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile Ala 
                405                 410                 415     


Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile Ser 
            420                 425                 430         


Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser 
        435                 440                 445             


Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile 
    450                 455                 460                 


Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser 
465                 470                 475                 480 


Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu 
                485                 490                 495     


Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr 
            500                 505                 510         


Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg 
        515                 520                 525             


Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser His 
    530                 535                 540                 


Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu Gly 
545                 550                 555                 560 


Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe Met 
                565                 570                 575     


Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile 
            580                 585                 590         


Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly 
        595                 600                 605             


Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr 
    610                 615                 620                 


Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn Ser 
625                 630                 635                 640 


Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe 
                645                 650                 655     


Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg 
            660                 665                 670         


Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val 
        675                 680                 685             


Tyr Val Phe Ile 
    690         


<210>  26
<211>  692
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-MPT26, geranyl diphosphate synthase, recombinant 
       membrane-bound prenyltransferase fusion protein

<400>  26

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys 
385                 390                 395                 400 


Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile Ala 
                405                 410                 415     


Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile Ser 
            420                 425                 430         


Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser 
        435                 440                 445             


Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile 
    450                 455                 460                 


Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser 
465                 470                 475                 480 


Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu 
                485                 490                 495     


Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr 
            500                 505                 510         


Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg 
        515                 520                 525             


Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser His 
    530                 535                 540                 


Val Gly Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly 
545                 550                 555                 560 


Leu Pro Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met 
                565                 570                 575     


Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile 
            580                 585                 590         


Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly 
        595                 600                 605             


Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr 
    610                 615                 620                 


Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn Ser 
625                 630                 635                 640 


Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Trp Leu Ile Leu 
                645                 650                 655     


Gln Thr Arg Asp Phe Ala Leu Thr Asn Tyr Asp Pro Glu Ala Gly Arg 
            660                 665                 670         


Arg Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val 
        675                 680                 685             


Tyr Val Phe Ile 
    690         


<210>  27
<211>  692
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-MPT31, geranyl diphosphate synthase, recombinant 
       membrane-bound prenyltransferase fusion protein

<400>  27

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Ala Cys 
385                 390                 395                 400 


Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile Ala 
                405                 410                 415     


Cys Gly Leu Phe Gly Arg Glu Leu Leu His Asn Thr Asn Leu Ile Ser 
            420                 425                 430         


Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser 
        435                 440                 445             


Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Leu His Ile 
    450                 455                 460                 


Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Ala Ser Gly Glu Ile Ser 
465                 470                 475                 480 


Val Asn Thr Ala Trp Ile Met Ser Ile Ile Val Ala Leu Thr Gly Leu 
                485                 490                 495     


Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr 
            500                 505                 510         


Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg 
        515                 520                 525             


Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser His 
    530                 535                 540                 


Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu Gly 
545                 550                 555                 560 


Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe Met 
                565                 570                 575     


Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile 
            580                 585                 590         


Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly 
        595                 600                 605             


Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr 
    610                 615                 620                 


Leu Val Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser 
625                 630                 635                 640 


Asn Ile Met Ile Leu Ser His Ala Ile Leu Ala Phe Trp Leu Ile Leu 
                645                 650                 655     


Gln Thr Arg Asp Phe Ala Leu Thr Asn Tyr Asp Pro Glu Ala Gly Arg 
            660                 665                 670         


Arg Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Leu Val 
        675                 680                 685             


Tyr Val Phe Ile 
    690         


<210>  28
<211>  52
<212>  PRT
<213>  Artificial

<220>
<223>  F10 linker

<400>  28

Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Glu Ala Ala Ala Lys 
            20                  25                  30          


Glu Ala Ala Ala Lys Ala Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 
        35                  40                  45              


Lys Ala Gly Gly 
    50          


<210>  29
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  F11 linker

<400>  29

Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser 
        35                  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  F12 linker

<400>  30

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  31
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  F13 linker

<400>  31

Gly Gly Ser Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe Gly 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  F14 linker

<400>  32

Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Pro Ala 
1               5                   10                  15      


Pro Ala Pro Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly 
            20                  25                  30          


Gly 
    


<210>  33
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  F15 linker

<400>  33

Gly Gly Ser Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Ala Gly Gly Ser Gly Gly 
            20          


<210>  34
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  F16 linker

<400>  34

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  35
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  F17 linker

<400>  35

Gly Gly Gly Gly Ser 
1               5   


<210>  36
<211>  48
<212>  PRT
<213>  Artificial

<220>
<223>  F18 linker

<400>  36

Gly Gly Gly Gly Ser Leu Glu Asp Pro Ala Val Trp Glu Ala Gly Lys 
1               5                   10                  15      


Val Val Ala Lys Gly Val Gly Thr Ala Asp Ile Thr Ala Thr Thr Ser 
            20                  25                  30          


Asn Gly Leu Ile Ala Ser Ser Glu Glu Ala Asp Asn Ala Ala Thr Ser 
        35                  40                  45              


<210>  37
<211>  285
<212>  PRT
<213>  Artificial

<220>
<223>  APT73.74 (mutant soluble aromatic prenyltransferase)

<400>  37

Met Asp Glu Val Tyr Ala Ala Val Glu Gln Thr Ser Arg Leu Leu Asp 
1               5                   10                  15      


Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp Lys Ala Phe Gly 
            20                  25                  30          


Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met Ala Ala Gly Glu 
        35                  40                  45              


Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu Arg Pro Glu Gly 
    50                  55                  60                  


Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe Ile Glu Pro Thr 
65                  70                  75                  80  


Asp His Pro Val Gly Ser Val Leu Ala Glu Val Gly Lys Arg Phe Ala 
                85                  90                  95      


Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly Gly Phe Lys Lys 
            100                 105                 110         


Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro Leu Ala Gln Phe 
        115                 120                 125             


Ala Glu Val Pro Ser Val Pro Pro Cys Leu Ala Gly His Val Glu Thr 
    130                 135                 140                 


Leu Thr Arg Leu Gly Phe Asp Asp Lys Val Ser Ile Ile Gly Val Asn 
145                 150                 155                 160 


Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala Ser Ala Val Asp 
                165                 170                 175     


Thr Gly Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly Tyr Pro Glu Pro 
            180                 185                 190         


Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe Arg Leu Tyr Pro 
        195                 200                 205             


Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile Cys Phe Ala Val 
    210                 215                 220                 


His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His Asp Glu Pro Thr 
225                 230                 235                 240 


Glu Ala Phe Ala Arg Gln Val Pro His Val Tyr Glu Gly Gly Arg Glu 
                245                 250                 255     


Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala Ser Tyr Tyr Lys 
            260                 265                 270         


Leu Ala Ala Leu Tyr Gln Lys Ala Arg Arg Cys Leu His 
        275                 280                 285 


<210>  38
<211>  285
<212>  PRT
<213>  Artificial

<220>
<223>  APT73.77 (mutant soluble aromatic prenyltransferase)

<400>  38

Met Asp Glu Val Tyr Ala Ala Val Glu Gln Thr Ser Arg Leu Leu Asp 
1               5                   10                  15      


Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp Lys Ala Phe Gly 
            20                  25                  30          


Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met Ala Ala Gly Glu 
        35                  40                  45              


Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu Arg Pro Glu Gly 
    50                  55                  60                  


Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe Ile Glu Pro Thr 
65                  70                  75                  80  


Asp His Pro Val Gly Ser Val Leu Ala Glu Val Gly Lys Arg Phe Ala 
                85                  90                  95      


Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly Gly Phe Lys Lys 
            100                 105                 110         


Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro Leu Ala Gln Phe 
        115                 120                 125             


Ala Glu Val Pro Ser Val Pro Pro Cys Leu Ala Gly His Val Glu Thr 
    130                 135                 140                 


Leu Thr Arg Leu Gly Phe Asp Asp Lys Val Ser Ile Ile Gly Val Asn 
145                 150                 155                 160 


Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala Ser Ala Val Asp 
                165                 170                 175     


Thr Gly Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly Tyr Pro Glu Pro 
            180                 185                 190         


Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe Arg Leu Tyr Pro 
        195                 200                 205             


Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile Cys Phe Ala Val 
    210                 215                 220                 


His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His Asp Glu Pro Thr 
225                 230                 235                 240 


Glu Ala Phe Ala Arg Gln Val Pro His Val Tyr Glu Gly Gly Arg Glu 
                245                 250                 255     


Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala Ser Tyr Tyr Lys 
            260                 265                 270         


Leu Ala Ala Leu Tyr Gln Lys Ala Arg Arg Cys Leu Asp 
        275                 280                 285 


<210>  39
<211>  284
<212>  PRT
<213>  Unknown

<220>
<223>  APT89.38 (soluble aromatic prenyltransferase)

<400>  39

Met Asp Glu Val Tyr Ala Ala Val Glu Arg Thr Ser Arg Leu Leu Asp 
1               5                   10                  15      


Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp Lys Ala Phe Gly 
            20                  25                  30          


Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met Ala Ala Gly Glu 
        35                  40                  45              


Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu Arg Pro Glu Gly 
    50                  55                  60                  


Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe Ile Glu Pro Thr 
65                  70                  75                  80  


Asp His Pro Val Gly Ser Val Leu Ala Glu Val Asn Lys Arg Cys Glu 
                85                  90                  95      


Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly Gly Phe Lys Lys 
            100                 105                 110         


Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro Leu Ala Glu Phe 
        115                 120                 125             


Ala Arg Ile Pro Ser Val Pro Pro Cys Leu Ala Gly His Val Asp Thr 
    130                 135                 140                 


Leu Thr Arg Leu Gly Leu Asp Asp Lys Val Ser Ala Ile Gly Val Asn 
145                 150                 155                 160 


Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala Ser Ala Val Ala 
                165                 170                 175     


Thr Asp Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly Tyr Pro Glu Pro 
            180                 185                 190         


Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe Arg Leu Tyr Pro 
        195                 200                 205             


Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile Cys Phe Ala Val 
    210                 215                 220                 


His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His Asp Glu Pro Thr 
225                 230                 235                 240 


Glu Ala Phe Ala Arg Glu Val Pro His Val Tyr Glu Gly Gly Arg Glu 
                245                 250                 255     


Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala Ala Tyr Tyr Lys 
            260                 265                 270         


Leu Ala Ala Glu Tyr Gln Lys Glu Arg Arg Cys Leu 
        275                 280                 


<210>  40

<400>  40
000

<210>  41

<400>  41
000

<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45

<400>  45
000

<210>  46

<400>  46
000

<210>  47

<400>  47
000

<210>  48

<400>  48
000

<210>  49

<400>  49
000

<210>  50

<400>  50
000

<210>  51

<400>  51
000

<210>  52
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT4.1 (point mutant, membrane-bound prenyltransferase)

<400>  52

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Leu Val Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys 
                245                 250                 255     


Ser Asn Ile Met Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  53
<211>  683
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F9-MPT4.1, geranyl diphosphate synthase, point mutant 
       membrane-bound prenyltransferase fusion protein

<400>  53

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser Ile Ala Thr Lys Ile 
    370                 375                 380                 


Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro Tyr Val Val 
385                 390                 395                 400 


Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Arg Glu Leu Phe 
                405                 410                 415     


Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp Lys Ala Phe Phe 
            420                 425                 430         


Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala Ile Met Asn 
        435                 440                 445             


Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro 
    450                 455                 460                 


Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile 
465                 470                 475                 480 


Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu Lys Ser Ala 
                485                 490                 495     


Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala 
            500                 505                 510         


Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe Thr Asn Phe 
        515                 520                 525             


Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr Ser Tyr Ser 
    530                 535                 540                 


Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg Pro Ala Phe 
545                 550                 555                 560 


Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr Ile Ala Phe 
                565                 570                 575     


Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser 
            580                 585                 590         


Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe Val Val Ser 
        595                 600                 605             


Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile Gly Ile Ile 
    610                 615                 620                 


Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser His Ala Ile 
625                 630                 635                 640 


Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn 
                645                 650                 655     


Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu 
            660                 665                 670         


Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
        675                 680             


<210>  54
<211>  668
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F5-MPT4.1, geranyl diphosphate synthase, point mutant 
       membrane-bound prenyltransferase fusion protein

<400>  54

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser Ile Ala Thr Lys 
        355                 360                 365             


Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro Tyr Ala 
    370                 375                 380                 


Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Arg Glu Leu 
385                 390                 395                 400 


Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp Lys Ala Phe 
                405                 410                 415     


Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala Ile Met 
            420                 425                 430         


Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro Asp Leu 
        435                 440                 445             


Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile Leu Ser 
    450                 455                 460                 


Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu Lys Ser 
465                 470                 475                 480 


Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala Gly Phe 
                485                 490                 495     


Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe Thr Asn 
            500                 505                 510         


Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr Ser Tyr 
        515                 520                 525             


Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg Pro Ala 
    530                 535                 540                 


Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr Ile Ala 
545                 550                 555                 560 


Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr Gly Val 
                565                 570                 575     


Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe Val Val 
            580                 585                 590         


Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile Gly Ile 
        595                 600                 605             


Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser His Ala 
    610                 615                 620                 


Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala Leu Ala 
625                 630                 635                 640 


Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile Trp Leu 
                645                 650                 655     


Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
            660                 665             


<210>  55
<211>  705
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F10-MPT4.1, geranyl diphosphate synthase, point mutant 
       membrane-bound prenyltransferase fusion protein

<400>  55

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 
        355                 360                 365             


Lys Ala Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Glu 
    370                 375                 380                 


Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly Met Ser Asp Asn 
385                 390                 395                 400 


Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu 
                405                 410                 415     


Gln Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu 
            420                 425                 430         


Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu 
        435                 440                 445             


Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe 
    450                 455                 460                 


Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile 
465                 470                 475                 480 


Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr 
                485                 490                 495     


Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr 
            500                 505                 510         


Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly 
        515                 520                 525             


Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln 
    530                 535                 540                 


Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu 
545                 550                 555                 560 


Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe 
                565                 570                 575     


Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met 
            580                 585                 590         


Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp 
        595                 600                 605             


Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn 
    610                 615                 620                 


Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser 
625                 630                 635                 640 


Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met 
                645                 650                 655     


Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg 
            660                 665                 670         


Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe 
        675                 680                 685             


Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe 
    690                 695                 700                 


Ile 
705 


<210>  56
<211>  692
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-MPT4.1, geranyl diphosphate synthase, point mutant 
       membrane-bound prenyltransferase fusion protein

<400>  56

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys 
385                 390                 395                 400 


Trp Lys Leu Gln Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala 
                405                 410                 415     


Cys Gly Leu Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser 
            420                 425                 430         


Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser 
        435                 440                 445             


Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile 
    450                 455                 460                 


Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser 
465                 470                 475                 480 


Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu 
                485                 490                 495     


Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr 
            500                 505                 510         


Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg 
        515                 520                 525             


Trp Lys Gln Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His 
    530                 535                 540                 


Val Gly Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly 
545                 550                 555                 560 


Leu Pro Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met 
                565                 570                 575     


Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile 
            580                 585                 590         


Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly 
        595                 600                 605             


Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr 
    610                 615                 620                 


Leu Val Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser 
625                 630                 635                 640 


Asn Ile Met Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe 
                645                 650                 655     


Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg 
            660                 665                 670         


Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val 
        675                 680                 685             


Tyr Val Phe Ile 
    690         


<210>  57
<211>  658
<212>  PRT
<213>  Artificial

<220>
<223>  GPS3-F11-MPT4.1, geranyl diphosphate synthase, point mutant 
       membrane-bound prenyltransferase fusion protein

<400>  57

Met Gln Leu Leu Asn Pro Pro Gln Lys Gly Lys Lys Ala Val Glu Phe 
1               5                   10                  15      


Asp Phe Asn Lys Tyr Met Asp Ser Lys Ala Met Thr Val Asn Glu Ala 
            20                  25                  30          


Leu Asn Lys Ala Ile Pro Leu Arg Tyr Pro Gln Lys Ile Tyr Glu Ser 
        35                  40                  45              


Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg Pro Val Leu 
    50                  55                  60                  


Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Thr Glu Glu Leu Ala Ile 
65                  70                  75                  80  


Pro Thr Ala Cys Ala Ile Glu Met Ile His Thr Met Ser Leu Met His 
                85                  90                  95      


Asp Asp Leu Pro Cys Ile Asp Asn Asp Asp Leu Arg Arg Gly Lys Pro 
            100                 105                 110         


Thr Asn His Lys Ile Phe Gly Glu Asp Thr Ala Val Thr Ala Gly Asn 
        115                 120                 125             


Ala Leu His Ser Tyr Ala Phe Glu His Ile Ala Val Ser Thr Ser Lys 
    130                 135                 140                 


Thr Val Gly Ala Asp Arg Ile Leu Arg Met Val Ser Glu Leu Gly Arg 
145                 150                 155                 160 


Ala Thr Gly Ser Glu Gly Val Met Gly Gly Gln Met Val Asp Ile Ala 
                165                 170                 175     


Ser Glu Gly Asp Pro Ser Ile Asp Leu Gln Thr Leu Glu Trp Ile His 
            180                 185                 190         


Ile His Lys Thr Ala Met Leu Leu Glu Cys Ser Val Val Cys Gly Ala 
        195                 200                 205             


Ile Ile Gly Gly Ala Ser Glu Ile Val Ile Glu Arg Ala Arg Arg Tyr 
    210                 215                 220                 


Ala Arg Cys Val Gly Leu Leu Phe Gln Val Val Asp Asp Ile Leu Asp 
225                 230                 235                 240 


Val Thr Lys Ser Ser Asp Glu Leu Gly Lys Thr Ala Gly Lys Asp Leu 
                245                 250                 255     


Ile Ser Asp Lys Ala Thr Tyr Pro Lys Leu Met Gly Leu Glu Lys Ala 
            260                 265                 270         


Lys Glu Phe Ser Asp Glu Leu Leu Asn Arg Ala Lys Gly Glu Leu Ser 
        275                 280                 285             


Cys Phe Asp Pro Val Lys Ala Ala Pro Leu Leu Gly Leu Ala Asp Tyr 
    290                 295                 300                 


Val Ala Phe Arg Gln Asn Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala 
305                 310                 315                 320 


Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                325                 330                 335     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp 
            340                 345                 350         


Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys 
        355                 360                 365             


Leu Gln Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly 
    370                 375                 380                 


Leu Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly 
385                 390                 395                 400 


Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn 
                405                 410                 415     


Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg 
            420                 425                 430         


Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu 
        435                 440                 445             


Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val 
    450                 455                 460                 


Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe 
465                 470                 475                 480 


Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys 
                485                 490                 495     


Gln Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly 
            500                 505                 510         


Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro 
        515                 520                 525             


Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val 
    530                 535                 540                 


Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly 
545                 550                 555                 560 


Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg 
                565                 570                 575     


Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val 
            580                 585                 590         


Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile 
        595                 600                 605             


Met Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr 
    610                 615                 620                 


Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe 
625                 630                 635                 640 


Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val 
                645                 650                 655     


Phe Ile 
        


<210>  58
<211>  719
<212>  PRT
<213>  Artificial

<220>
<223>  GPS2-F11-MPT4.1, geranyl diphosphate synthase, point mutant 
       membrane-bound prenyltransferase fusion protein

<400>  58

Met Lys Asp Val Ser Leu Ser Ser Phe Asp Ala His Asp Leu Asp Leu 
1               5                   10                  15      


Asp Lys Phe Pro Glu Val Val Arg Asp Arg Leu Thr Gln Phe Leu Asp 
            20                  25                  30          


Ala Gln Glu Leu Thr Ile Ala Asp Ile Gly Ala Pro Val Thr Asp Ala 
        35                  40                  45              


Val Ala His Leu Arg Ser Phe Val Leu Asn Gly Gly Lys Arg Ile Arg 
    50                  55                  60                  


Pro Leu Tyr Ala Trp Ala Gly Phe Leu Ala Ala Gln Gly His Lys Asn 
65                  70                  75                  80  


Ser Ser Glu Lys Leu Glu Ser Val Leu Asp Ala Ala Ala Ser Leu Glu 
                85                  90                  95      


Phe Ile Gln Ala Cys Ala Leu Ile His Asp Asp Ile Ile Asp Ser Ser 
            100                 105                 110         


Asp Thr Arg Arg Gly Ala Pro Thr Val His Arg Ala Val Glu Ala Asp 
        115                 120                 125             


His Arg Ala Asn Asn Phe Glu Gly Asp Pro Glu His Phe Gly Val Ser 
    130                 135                 140                 


Val Ser Ile Leu Ala Gly Asp Met Ala Leu Val Trp Ala Glu Asp Met 
145                 150                 155                 160 


Leu Gln Asp Ser Gly Leu Ser Ala Glu Ala Leu Ala Arg Thr Arg Asp 
                165                 170                 175     


Ala Trp Arg Gly Met Arg Thr Glu Val Ile Gly Gly Gln Leu Leu Asp 
            180                 185                 190         


Ile Tyr Leu Glu Ser His Ala Asn Glu Ser Val Glu Leu Ala Asp Ser 
        195                 200                 205             


Val Asn Arg Phe Lys Thr Ala Ala Tyr Thr Ile Ala Arg Pro Leu His 
    210                 215                 220                 


Leu Gly Ala Ser Ile Ala Gly Gly Ser Pro Gln Leu Ile Asp Ala Leu 
225                 230                 235                 240 


Leu His Tyr Gly His Asp Ile Gly Ile Ala Phe Gln Leu Arg Asp Asp 
                245                 250                 255     


Leu Leu Gly Val Phe Gly Asp Pro Ala Ile Thr Gly Lys Pro Ala Gly 
            260                 265                 270         


Asp Asp Ile Arg Glu Gly Lys Arg Thr Val Leu Leu Ala Leu Ala Leu 
        275                 280                 285             


Gln Arg Ala Asp Lys Gln Ser Pro Glu Ala Ala Thr Ala Ile Arg Ala 
    290                 295                 300                 


Gly Val Gly Lys Val Thr Ser Pro Glu Asp Ile Ala Val Ile Thr Glu 
305                 310                 315                 320 


His Ile Arg Ala Thr Gly Ala Glu Glu Glu Val Glu Gln Arg Ile Ser 
                325                 330                 335     


Gln Leu Thr Glu Ser Gly Leu Ala His Leu Asp Asp Val Asp Ile Pro 
            340                 345                 350         


Asp Glu Val Arg Ala Gln Leu Arg Ala Leu Ala Ile Arg Ser Thr Glu 
        355                 360                 365             


Arg Arg Met Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
    370                 375                 380                 


Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser Ile 
                405                 410                 415     


Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg 
            420                 425                 430         


Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly 
        435                 440                 445             


Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp 
    450                 455                 460                 


Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala 
465                 470                 475                 480 


Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys 
                485                 490                 495     


Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp 
            500                 505                 510         


Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys 
        515                 520                 525             


Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe 
    530                 535                 540                 


Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro 
545                 550                 555                 560 


Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe 
                565                 570                 575     


Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp 
            580                 585                 590         


Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met 
        595                 600                 605             


Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys 
    610                 615                 620                 


Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr 
625                 630                 635                 640 


Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser 
                645                 650                 655     


Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu 
            660                 665                 670         


Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu 
        675                 680                 685             


Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe 
    690                 695                 700                 


Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
705                 710                 715                 


<210>  59
<211>  646
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F16-APT73.74, geranyl diphosphate synthase, mutant soluble
       aromatic prenyltransferase fusion protein

<400>  59

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Gly Ser Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Asp Glu Val Tyr Ala Ala 
        355                 360                 365             


Val Glu Gln Thr Ser Arg Leu Leu Asp Val Pro Cys Ser Pro Asp Arg 
    370                 375                 380                 


Phe Glu Pro Val Trp Lys Ala Phe Gly Asp Gln Leu Pro Asp Ser His 
385                 390                 395                 400 


Leu Val Phe Ser Met Ala Ala Gly Glu Ala His Arg Gly Glu Leu Asp 
                405                 410                 415     


Phe Asp Phe Ser Leu Arg Pro Glu Gly Ala Asp Pro Tyr Thr Thr Ala 
            420                 425                 430         


Leu Glu His Gly Phe Ile Glu Pro Thr Asp His Pro Val Gly Ser Val 
        435                 440                 445             


Leu Ala Glu Val Gly Lys Arg Phe Ala Ile Ala Ser Tyr Gly Val Glu 
    450                 455                 460                 


Tyr Gly Val Val Gly Gly Phe Lys Lys Ser Tyr Ala Phe Phe Pro Leu 
465                 470                 475                 480 


Asp Asp Phe Pro Pro Leu Ala Gln Phe Ala Glu Val Pro Ser Val Pro 
                485                 490                 495     


Pro Cys Leu Ala Gly His Val Glu Thr Leu Thr Arg Leu Gly Phe Asp 
            500                 505                 510         


Asp Lys Val Ser Ile Ile Gly Val Asn Tyr Arg Lys Asn Thr Leu Asn 
        515                 520                 525             


Val Tyr Leu Ala Ala Ser Ala Val Asp Thr Gly Asp Lys Leu Ala Leu 
    530                 535                 540                 


Leu Arg Ala Phe Gly Tyr Pro Glu Pro Asp Ala Arg Val Arg Gln Phe 
545                 550                 555                 560 


Ile Glu Arg Ser Phe Arg Leu Tyr Pro Thr Phe Asn Trp Asp Ser Ser 
                565                 570                 575     


Ala Ala Glu Arg Ile Cys Phe Ala Val His Thr Gln Gln Pro Gly Glu 
            580                 585                 590         


Leu Pro Ala Pro His Asp Glu Pro Thr Glu Ala Phe Ala Arg Gln Val 
        595                 600                 605             


Pro His Val Tyr Glu Gly Gly Arg Glu Phe Val Ser Gly Val Ala Leu 
    610                 615                 620                 


Ala Pro Ser Gly Ala Ser Tyr Tyr Lys Leu Ala Ala Leu Tyr Gln Lys 
625                 630                 635                 640 


Ala Arg Arg Cys Leu His 
                645     


<210>  60
<211>  634
<212>  PRT
<213>  Artificial

<220>
<223>  APT73.74-F17-GPS1.1, mutant soluble aromatic prenyltransferase, 
       geranyl diphosphate synthase fusion protein

<400>  60

Met Asp Glu Val Tyr Ala Ala Val Glu Gln Thr Ser Arg Leu Leu Asp 
1               5                   10                  15      


Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp Lys Ala Phe Gly 
            20                  25                  30          


Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met Ala Ala Gly Glu 
        35                  40                  45              


Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu Arg Pro Glu Gly 
    50                  55                  60                  


Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe Ile Glu Pro Thr 
65                  70                  75                  80  


Asp His Pro Val Gly Ser Val Leu Ala Glu Val Gly Lys Arg Phe Ala 
                85                  90                  95      


Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly Gly Phe Lys Lys 
            100                 105                 110         


Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro Leu Ala Gln Phe 
        115                 120                 125             


Ala Glu Val Pro Ser Val Pro Pro Cys Leu Ala Gly His Val Glu Thr 
    130                 135                 140                 


Leu Thr Arg Leu Gly Phe Asp Asp Lys Val Ser Ile Ile Gly Val Asn 
145                 150                 155                 160 


Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala Ser Ala Val Asp 
                165                 170                 175     


Thr Gly Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly Tyr Pro Glu Pro 
            180                 185                 190         


Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe Arg Leu Tyr Pro 
        195                 200                 205             


Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile Cys Phe Ala Val 
    210                 215                 220                 


His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His Asp Glu Pro Thr 
225                 230                 235                 240 


Glu Ala Phe Ala Arg Gln Val Pro His Val Tyr Glu Gly Gly Arg Glu 
                245                 250                 255     


Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala Ser Tyr Tyr Lys 
            260                 265                 270         


Leu Ala Ala Leu Tyr Gln Lys Ala Arg Arg Cys Leu His Gly Gly Gly 
        275                 280                 285             


Gly Ser Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser 
    290                 295                 300                 


Glu Glu Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala 
305                 310                 315                 320 


Val Gln Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys 
                325                 330                 335     


Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly 
            340                 345                 350         


Lys Lys Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly 
        355                 360                 365             


Trp Leu Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile 
    370                 375                 380                 


Met Asp Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys 
385                 390                 395                 400 


Pro Lys Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser 
                405                 410                 415     


Gly Ile Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr 
            420                 425                 430         


Ile Asp Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu 
        435                 440                 445             


Gly Gln Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu 
    450                 455                 460                 


Asn Arg Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr 
465                 470                 475                 480 


Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala 
                485                 490                 495     


Gly Ile Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile 
            500                 505                 510         


Pro Leu Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe 
        515                 520                 525             


Gly Asp Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn 
    530                 535                 540                 


Lys Cys Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu 
545                 550                 555                 560 


Gln Arg Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys 
                565                 570                 575     


Glu Leu Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp 
            580                 585                 590         


Tyr Leu Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile 
        595                 600                 605             


Glu Gln Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala 
    610                 615                 620                 


Phe Leu Ala Lys Ile Tyr Lys Arg Gln Lys 
625                 630                 


<210>  61
<211>  677
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F18-APT73.74, geranyl diphosphate synthase, mutant soluble
       aromatic prenyltransferase fusion protein

<400>  61

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Gly Gly Ser Leu Glu Asp 
            340                 345                 350         


Pro Ala Val Trp Glu Ala Gly Lys Val Val Ala Lys Gly Val Gly Thr 
        355                 360                 365             


Ala Asp Ile Thr Ala Thr Thr Ser Asn Gly Leu Ile Ala Ser Ser Glu 
    370                 375                 380                 


Glu Ala Asp Asn Ala Ala Thr Ser Met Asp Glu Val Tyr Ala Ala Val 
385                 390                 395                 400 


Glu Gln Thr Ser Arg Leu Leu Asp Val Pro Cys Ser Pro Asp Arg Phe 
                405                 410                 415     


Glu Pro Val Trp Lys Ala Phe Gly Asp Gln Leu Pro Asp Ser His Leu 
            420                 425                 430         


Val Phe Ser Met Ala Ala Gly Glu Ala His Arg Gly Glu Leu Asp Phe 
        435                 440                 445             


Asp Phe Ser Leu Arg Pro Glu Gly Ala Asp Pro Tyr Thr Thr Ala Leu 
    450                 455                 460                 


Glu His Gly Phe Ile Glu Pro Thr Asp His Pro Val Gly Ser Val Leu 
465                 470                 475                 480 


Ala Glu Val Gly Lys Arg Phe Ala Ile Ala Ser Tyr Gly Val Glu Tyr 
                485                 490                 495     


Gly Val Val Gly Gly Phe Lys Lys Ser Tyr Ala Phe Phe Pro Leu Asp 
            500                 505                 510         


Asp Phe Pro Pro Leu Ala Gln Phe Ala Glu Val Pro Ser Val Pro Pro 
        515                 520                 525             


Cys Leu Ala Gly His Val Glu Thr Leu Thr Arg Leu Gly Phe Asp Asp 
    530                 535                 540                 


Lys Val Ser Ile Ile Gly Val Asn Tyr Arg Lys Asn Thr Leu Asn Val 
545                 550                 555                 560 


Tyr Leu Ala Ala Ser Ala Val Asp Thr Gly Asp Lys Leu Ala Leu Leu 
                565                 570                 575     


Arg Ala Phe Gly Tyr Pro Glu Pro Asp Ala Arg Val Arg Gln Phe Ile 
            580                 585                 590         


Glu Arg Ser Phe Arg Leu Tyr Pro Thr Phe Asn Trp Asp Ser Ser Ala 
        595                 600                 605             


Ala Glu Arg Ile Cys Phe Ala Val His Thr Gln Gln Pro Gly Glu Leu 
    610                 615                 620                 


Pro Ala Pro His Asp Glu Pro Thr Glu Ala Phe Ala Arg Gln Val Pro 
625                 630                 635                 640 


His Val Tyr Glu Gly Gly Arg Glu Phe Val Ser Gly Val Ala Leu Ala 
                645                 650                 655     


Pro Ser Gly Ala Ser Tyr Tyr Lys Leu Ala Ala Leu Tyr Gln Lys Ala 
            660                 665                 670         


Arg Arg Cys Leu His 
        675         


<210>  62
<211>  677
<212>  PRT
<213>  Artificial

<220>
<223>  APT73.74-F18-GPS1.1, mutant soluble aromatic prenyltransferase, 
       geranyl diphosphate synthase fusion protein

<400>  62

Met Asp Glu Val Tyr Ala Ala Val Glu Gln Thr Ser Arg Leu Leu Asp 
1               5                   10                  15      


Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp Lys Ala Phe Gly 
            20                  25                  30          


Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met Ala Ala Gly Glu 
        35                  40                  45              


Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu Arg Pro Glu Gly 
    50                  55                  60                  


Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe Ile Glu Pro Thr 
65                  70                  75                  80  


Asp His Pro Val Gly Ser Val Leu Ala Glu Val Gly Lys Arg Phe Ala 
                85                  90                  95      


Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly Gly Phe Lys Lys 
            100                 105                 110         


Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro Leu Ala Gln Phe 
        115                 120                 125             


Ala Glu Val Pro Ser Val Pro Pro Cys Leu Ala Gly His Val Glu Thr 
    130                 135                 140                 


Leu Thr Arg Leu Gly Phe Asp Asp Lys Val Ser Ile Ile Gly Val Asn 
145                 150                 155                 160 


Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala Ser Ala Val Asp 
                165                 170                 175     


Thr Gly Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly Tyr Pro Glu Pro 
            180                 185                 190         


Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe Arg Leu Tyr Pro 
        195                 200                 205             


Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile Cys Phe Ala Val 
    210                 215                 220                 


His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His Asp Glu Pro Thr 
225                 230                 235                 240 


Glu Ala Phe Ala Arg Gln Val Pro His Val Tyr Glu Gly Gly Arg Glu 
                245                 250                 255     


Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala Ser Tyr Tyr Lys 
            260                 265                 270         


Leu Ala Ala Leu Tyr Gln Lys Ala Arg Arg Cys Leu His Gly Gly Gly 
        275                 280                 285             


Gly Ser Leu Glu Asp Pro Ala Val Trp Glu Ala Gly Lys Val Val Ala 
    290                 295                 300                 


Lys Gly Val Gly Thr Ala Asp Ile Thr Ala Thr Thr Ser Asn Gly Leu 
305                 310                 315                 320 


Ile Ala Ser Ser Glu Glu Ala Asp Asn Ala Ala Thr Ser Met Ser Lys 
                325                 330                 335     


Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu Leu Val Gln 
            340                 345                 350         


Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln Trp Phe Ser 
        355                 360                 365             


Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn Arg Gly Leu 
    370                 375                 380                 


Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys Glu Leu Asp 
385                 390                 395                 400 


Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu Ile Glu Leu 
                405                 410                 415     


Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp Glu Ser Lys 
            420                 425                 430         


Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys Val Gly Met 
        435                 440                 445             


Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile Tyr Ile Leu 
    450                 455                 460                 


Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp Leu Val Glu 
465                 470                 475                 480 


Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln Leu Val Asp 
                485                 490                 495     


Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg Phe Ser Leu 
            500                 505                 510         


Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr Tyr Ser Phe 
        515                 520                 525             


Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile Thr Asn Pro 
    530                 535                 540                 


Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu Gly Glu Tyr 
545                 550                 555                 560 


Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp Pro Glu Phe 
                565                 570                 575     


Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu 
            580                 585                 590         


Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg Gln Ile Leu 
        595                 600                 605             


Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu Val Ile Lys 
    610                 615                 620                 


Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu Asp Tyr Glu 
625                 630                 635                 640 


Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln Val Asp Glu 
                645                 650                 655     


Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu Ala Lys Ile 
            660                 665                 670         


Tyr Lys Arg Gln Lys 
        675         


<210>  63
<211>  646
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F16-APT73.77, geranyl diphosphate synthase, mutant soluble
       aromatic prenyltransferase fusion protein

<400>  63

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Gly Ser Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Asp Glu Val Tyr Ala Ala 
        355                 360                 365             


Val Glu Gln Thr Ser Arg Leu Leu Asp Val Pro Cys Ser Pro Asp Arg 
    370                 375                 380                 


Phe Glu Pro Val Trp Lys Ala Phe Gly Asp Gln Leu Pro Asp Ser His 
385                 390                 395                 400 


Leu Val Phe Ser Met Ala Ala Gly Glu Ala His Arg Gly Glu Leu Asp 
                405                 410                 415     


Phe Asp Phe Ser Leu Arg Pro Glu Gly Ala Asp Pro Tyr Thr Thr Ala 
            420                 425                 430         


Leu Glu His Gly Phe Ile Glu Pro Thr Asp His Pro Val Gly Ser Val 
        435                 440                 445             


Leu Ala Glu Val Gly Lys Arg Phe Ala Ile Ala Ser Tyr Gly Val Glu 
    450                 455                 460                 


Tyr Gly Val Val Gly Gly Phe Lys Lys Ser Tyr Ala Phe Phe Pro Leu 
465                 470                 475                 480 


Asp Asp Phe Pro Pro Leu Ala Gln Phe Ala Glu Val Pro Ser Val Pro 
                485                 490                 495     


Pro Cys Leu Ala Gly His Val Glu Thr Leu Thr Arg Leu Gly Phe Asp 
            500                 505                 510         


Asp Lys Val Ser Ile Ile Gly Val Asn Tyr Arg Lys Asn Thr Leu Asn 
        515                 520                 525             


Val Tyr Leu Ala Ala Ser Ala Val Asp Thr Gly Asp Lys Leu Ala Leu 
    530                 535                 540                 


Leu Arg Ala Phe Gly Tyr Pro Glu Pro Asp Ala Arg Val Arg Gln Phe 
545                 550                 555                 560 


Ile Glu Arg Ser Phe Arg Leu Tyr Pro Thr Phe Asn Trp Asp Ser Ser 
                565                 570                 575     


Ala Ala Glu Arg Ile Cys Phe Ala Val His Thr Gln Gln Pro Gly Glu 
            580                 585                 590         


Leu Pro Ala Pro His Asp Glu Pro Thr Glu Ala Phe Ala Arg Gln Val 
        595                 600                 605             


Pro His Val Tyr Glu Gly Gly Arg Glu Phe Val Ser Gly Val Ala Leu 
    610                 615                 620                 


Ala Pro Ser Gly Ala Ser Tyr Tyr Lys Leu Ala Ala Leu Tyr Gln Lys 
625                 630                 635                 640 


Ala Arg Arg Cys Leu Asp 
                645     


<210>  64
<211>  634
<212>  PRT
<213>  Artificial

<220>
<223>  APT73.77-F17-GPS1.1, mutant soluble aromatic prenyltransferase, 
       geranyl diphosphate synthase fusion protein

<400>  64

Met Asp Glu Val Tyr Ala Ala Val Glu Gln Thr Ser Arg Leu Leu Asp 
1               5                   10                  15      


Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp Lys Ala Phe Gly 
            20                  25                  30          


Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met Ala Ala Gly Glu 
        35                  40                  45              


Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu Arg Pro Glu Gly 
    50                  55                  60                  


Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe Ile Glu Pro Thr 
65                  70                  75                  80  


Asp His Pro Val Gly Ser Val Leu Ala Glu Val Gly Lys Arg Phe Ala 
                85                  90                  95      


Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly Gly Phe Lys Lys 
            100                 105                 110         


Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro Leu Ala Gln Phe 
        115                 120                 125             


Ala Glu Val Pro Ser Val Pro Pro Cys Leu Ala Gly His Val Glu Thr 
    130                 135                 140                 


Leu Thr Arg Leu Gly Phe Asp Asp Lys Val Ser Ile Ile Gly Val Asn 
145                 150                 155                 160 


Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala Ser Ala Val Asp 
                165                 170                 175     


Thr Gly Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly Tyr Pro Glu Pro 
            180                 185                 190         


Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe Arg Leu Tyr Pro 
        195                 200                 205             


Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile Cys Phe Ala Val 
    210                 215                 220                 


His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His Asp Glu Pro Thr 
225                 230                 235                 240 


Glu Ala Phe Ala Arg Gln Val Pro His Val Tyr Glu Gly Gly Arg Glu 
                245                 250                 255     


Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala Ser Tyr Tyr Lys 
            260                 265                 270         


Leu Ala Ala Leu Tyr Gln Lys Ala Arg Arg Cys Leu Asp Gly Gly Gly 
        275                 280                 285             


Gly Ser Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser 
    290                 295                 300                 


Glu Glu Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala 
305                 310                 315                 320 


Val Gln Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys 
                325                 330                 335     


Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly 
            340                 345                 350         


Lys Lys Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly 
        355                 360                 365             


Trp Leu Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile 
    370                 375                 380                 


Met Asp Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys 
385                 390                 395                 400 


Pro Lys Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser 
                405                 410                 415     


Gly Ile Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr 
            420                 425                 430         


Ile Asp Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu 
        435                 440                 445             


Gly Gln Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu 
    450                 455                 460                 


Asn Arg Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr 
465                 470                 475                 480 


Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala 
                485                 490                 495     


Gly Ile Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile 
            500                 505                 510         


Pro Leu Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe 
        515                 520                 525             


Gly Asp Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn 
    530                 535                 540                 


Lys Cys Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu 
545                 550                 555                 560 


Gln Arg Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys 
                565                 570                 575     


Glu Leu Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp 
            580                 585                 590         


Tyr Leu Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile 
        595                 600                 605             


Glu Gln Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala 
    610                 615                 620                 


Phe Leu Ala Lys Ile Tyr Lys Arg Gln Lys 
625                 630                 


<210>  65
<211>  677
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F18-APT73.77, geranyl diphosphate synthase, mutant soluble
       aromatic prenyltransferase fusion protein

<400>  65

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Gly Gly Ser Leu Glu Asp 
            340                 345                 350         


Pro Ala Val Trp Glu Ala Gly Lys Val Val Ala Lys Gly Val Gly Thr 
        355                 360                 365             


Ala Asp Ile Thr Ala Thr Thr Ser Asn Gly Leu Ile Ala Ser Ser Glu 
    370                 375                 380                 


Glu Ala Asp Asn Ala Ala Thr Ser Met Asp Glu Val Tyr Ala Ala Val 
385                 390                 395                 400 


Glu Gln Thr Ser Arg Leu Leu Asp Val Pro Cys Ser Pro Asp Arg Phe 
                405                 410                 415     


Glu Pro Val Trp Lys Ala Phe Gly Asp Gln Leu Pro Asp Ser His Leu 
            420                 425                 430         


Val Phe Ser Met Ala Ala Gly Glu Ala His Arg Gly Glu Leu Asp Phe 
        435                 440                 445             


Asp Phe Ser Leu Arg Pro Glu Gly Ala Asp Pro Tyr Thr Thr Ala Leu 
    450                 455                 460                 


Glu His Gly Phe Ile Glu Pro Thr Asp His Pro Val Gly Ser Val Leu 
465                 470                 475                 480 


Ala Glu Val Gly Lys Arg Phe Ala Ile Ala Ser Tyr Gly Val Glu Tyr 
                485                 490                 495     


Gly Val Val Gly Gly Phe Lys Lys Ser Tyr Ala Phe Phe Pro Leu Asp 
            500                 505                 510         


Asp Phe Pro Pro Leu Ala Gln Phe Ala Glu Val Pro Ser Val Pro Pro 
        515                 520                 525             


Cys Leu Ala Gly His Val Glu Thr Leu Thr Arg Leu Gly Phe Asp Asp 
    530                 535                 540                 


Lys Val Ser Ile Ile Gly Val Asn Tyr Arg Lys Asn Thr Leu Asn Val 
545                 550                 555                 560 


Tyr Leu Ala Ala Ser Ala Val Asp Thr Gly Asp Lys Leu Ala Leu Leu 
                565                 570                 575     


Arg Ala Phe Gly Tyr Pro Glu Pro Asp Ala Arg Val Arg Gln Phe Ile 
            580                 585                 590         


Glu Arg Ser Phe Arg Leu Tyr Pro Thr Phe Asn Trp Asp Ser Ser Ala 
        595                 600                 605             


Ala Glu Arg Ile Cys Phe Ala Val His Thr Gln Gln Pro Gly Glu Leu 
    610                 615                 620                 


Pro Ala Pro His Asp Glu Pro Thr Glu Ala Phe Ala Arg Gln Val Pro 
625                 630                 635                 640 


His Val Tyr Glu Gly Gly Arg Glu Phe Val Ser Gly Val Ala Leu Ala 
                645                 650                 655     


Pro Ser Gly Ala Ser Tyr Tyr Lys Leu Ala Ala Leu Tyr Gln Lys Ala 
            660                 665                 670         


Arg Arg Cys Leu Asp 
        675         


<210>  66
<211>  677
<212>  PRT
<213>  Artificial

<220>
<223>  APT73.77-F18-GPS1.1, mutant soluble aromatic prenyltransferase, 
       geranyl diphosphate synthase fusion protein

<400>  66

Met Asp Glu Val Tyr Ala Ala Val Glu Gln Thr Ser Arg Leu Leu Asp 
1               5                   10                  15      


Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp Lys Ala Phe Gly 
            20                  25                  30          


Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met Ala Ala Gly Glu 
        35                  40                  45              


Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu Arg Pro Glu Gly 
    50                  55                  60                  


Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe Ile Glu Pro Thr 
65                  70                  75                  80  


Asp His Pro Val Gly Ser Val Leu Ala Glu Val Gly Lys Arg Phe Ala 
                85                  90                  95      


Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly Gly Phe Lys Lys 
            100                 105                 110         


Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro Leu Ala Gln Phe 
        115                 120                 125             


Ala Glu Val Pro Ser Val Pro Pro Cys Leu Ala Gly His Val Glu Thr 
    130                 135                 140                 


Leu Thr Arg Leu Gly Phe Asp Asp Lys Val Ser Ile Ile Gly Val Asn 
145                 150                 155                 160 


Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala Ser Ala Val Asp 
                165                 170                 175     


Thr Gly Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly Tyr Pro Glu Pro 
            180                 185                 190         


Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe Arg Leu Tyr Pro 
        195                 200                 205             


Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile Cys Phe Ala Val 
    210                 215                 220                 


His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His Asp Glu Pro Thr 
225                 230                 235                 240 


Glu Ala Phe Ala Arg Gln Val Pro His Val Tyr Glu Gly Gly Arg Glu 
                245                 250                 255     


Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala Ser Tyr Tyr Lys 
            260                 265                 270         


Leu Ala Ala Leu Tyr Gln Lys Ala Arg Arg Cys Leu Asp Gly Gly Gly 
        275                 280                 285             


Gly Ser Leu Glu Asp Pro Ala Val Trp Glu Ala Gly Lys Val Val Ala 
    290                 295                 300                 


Lys Gly Val Gly Thr Ala Asp Ile Thr Ala Thr Thr Ser Asn Gly Leu 
305                 310                 315                 320 


Ile Ala Ser Ser Glu Glu Ala Asp Asn Ala Ala Thr Ser Met Ser Lys 
                325                 330                 335     


Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu Leu Val Gln 
            340                 345                 350         


Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln Trp Phe Ser 
        355                 360                 365             


Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn Arg Gly Leu 
    370                 375                 380                 


Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys Glu Leu Asp 
385                 390                 395                 400 


Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu Ile Glu Leu 
                405                 410                 415     


Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp Glu Ser Lys 
            420                 425                 430         


Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys Val Gly Met 
        435                 440                 445             


Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile Tyr Ile Leu 
    450                 455                 460                 


Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp Leu Val Glu 
465                 470                 475                 480 


Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln Leu Val Asp 
                485                 490                 495     


Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg Phe Ser Leu 
            500                 505                 510         


Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr Tyr Ser Phe 
        515                 520                 525             


Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile Thr Asn Pro 
    530                 535                 540                 


Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu Gly Glu Tyr 
545                 550                 555                 560 


Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp Pro Glu Phe 
                565                 570                 575     


Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu 
            580                 585                 590         


Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg Gln Ile Leu 
        595                 600                 605             


Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu Val Ile Lys 
    610                 615                 620                 


Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu Asp Tyr Glu 
625                 630                 635                 640 


Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln Val Asp Glu 
                645                 650                 655     


Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu Ala Lys Ile 
            660                 665                 670         


Tyr Lys Arg Gln Lys 
        675         


<210>  67
<211>  645
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F16-APT89.38, geranyl diphosphate synthase, soluble 
       aromatic prenyltransferase fusion protein

<400>  67

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Gly Ser Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Asp Glu Val Tyr Ala Ala 
        355                 360                 365             


Val Glu Arg Thr Ser Arg Leu Leu Asp Val Pro Cys Ser Pro Asp Arg 
    370                 375                 380                 


Phe Glu Pro Val Trp Lys Ala Phe Gly Asp Gln Leu Pro Asp Ser His 
385                 390                 395                 400 


Leu Val Phe Ser Met Ala Ala Gly Glu Ala His Arg Gly Glu Leu Asp 
                405                 410                 415     


Phe Asp Phe Ser Leu Arg Pro Glu Gly Ala Asp Pro Tyr Thr Thr Ala 
            420                 425                 430         


Leu Glu His Gly Phe Ile Glu Pro Thr Asp His Pro Val Gly Ser Val 
        435                 440                 445             


Leu Ala Glu Val Asn Lys Arg Cys Glu Ile Ala Ser Tyr Gly Val Glu 
    450                 455                 460                 


Tyr Gly Val Val Gly Gly Phe Lys Lys Ser Tyr Ala Phe Phe Pro Leu 
465                 470                 475                 480 


Asp Asp Phe Pro Pro Leu Ala Glu Phe Ala Arg Ile Pro Ser Val Pro 
                485                 490                 495     


Pro Cys Leu Ala Gly His Val Asp Thr Leu Thr Arg Leu Gly Leu Asp 
            500                 505                 510         


Asp Lys Val Ser Ala Ile Gly Val Asn Tyr Arg Lys Asn Thr Leu Asn 
        515                 520                 525             


Val Tyr Leu Ala Ala Ser Ala Val Ala Thr Asp Asp Lys Leu Ala Leu 
    530                 535                 540                 


Leu Arg Ala Phe Gly Tyr Pro Glu Pro Asp Ala Arg Val Arg Gln Phe 
545                 550                 555                 560 


Ile Glu Arg Ser Phe Arg Leu Tyr Pro Thr Phe Asn Trp Asp Ser Ser 
                565                 570                 575     


Ala Ala Glu Arg Ile Cys Phe Ala Val His Thr Gln Gln Pro Gly Glu 
            580                 585                 590         


Leu Pro Ala Pro His Asp Glu Pro Thr Glu Ala Phe Ala Arg Glu Val 
        595                 600                 605             


Pro His Val Tyr Glu Gly Gly Arg Glu Phe Val Ser Gly Val Ala Leu 
    610                 615                 620                 


Ala Pro Ser Gly Ala Ala Tyr Tyr Lys Leu Ala Ala Glu Tyr Gln Lys 
625                 630                 635                 640 


Glu Arg Arg Cys Leu 
                645 


<210>  68
<211>  633
<212>  PRT
<213>  Artificial

<220>
<223>  APT89.38-F17-GPS1.1, soluble aromatic prenyltransferase, geranyl 
       diphosphate synthase fusion protein

<400>  68

Met Asp Glu Val Tyr Ala Ala Val Glu Arg Thr Ser Arg Leu Leu Asp 
1               5                   10                  15      


Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp Lys Ala Phe Gly 
            20                  25                  30          


Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met Ala Ala Gly Glu 
        35                  40                  45              


Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu Arg Pro Glu Gly 
    50                  55                  60                  


Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe Ile Glu Pro Thr 
65                  70                  75                  80  


Asp His Pro Val Gly Ser Val Leu Ala Glu Val Asn Lys Arg Cys Glu 
                85                  90                  95      


Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly Gly Phe Lys Lys 
            100                 105                 110         


Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro Leu Ala Glu Phe 
        115                 120                 125             


Ala Arg Ile Pro Ser Val Pro Pro Cys Leu Ala Gly His Val Asp Thr 
    130                 135                 140                 


Leu Thr Arg Leu Gly Leu Asp Asp Lys Val Ser Ala Ile Gly Val Asn 
145                 150                 155                 160 


Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala Ser Ala Val Ala 
                165                 170                 175     


Thr Asp Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly Tyr Pro Glu Pro 
            180                 185                 190         


Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe Arg Leu Tyr Pro 
        195                 200                 205             


Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile Cys Phe Ala Val 
    210                 215                 220                 


His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His Asp Glu Pro Thr 
225                 230                 235                 240 


Glu Ala Phe Ala Arg Glu Val Pro His Val Tyr Glu Gly Gly Arg Glu 
                245                 250                 255     


Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala Ala Tyr Tyr Lys 
            260                 265                 270         


Leu Ala Ala Glu Tyr Gln Lys Glu Arg Arg Cys Leu Gly Gly Gly Gly 
        275                 280                 285             


Ser Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu 
    290                 295                 300                 


Glu Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val 
305                 310                 315                 320 


Gln Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu 
                325                 330                 335     


Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys 
            340                 345                 350         


Lys Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp 
        355                 360                 365             


Leu Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met 
    370                 375                 380                 


Asp Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro 
385                 390                 395                 400 


Lys Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly 
                405                 410                 415     


Ile Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile 
            420                 425                 430         


Asp Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly 
        435                 440                 445             


Gln Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn 
    450                 455                 460                 


Arg Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala 
465                 470                 475                 480 


Tyr Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly 
                485                 490                 495     


Ile Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro 
            500                 505                 510         


Leu Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly 
        515                 520                 525             


Asp Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys 
    530                 535                 540                 


Cys Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln 
545                 550                 555                 560 


Arg Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu 
                565                 570                 575     


Leu Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr 
            580                 585                 590         


Leu Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu 
        595                 600                 605             


Gln Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe 
    610                 615                 620                 


Leu Ala Lys Ile Tyr Lys Arg Gln Lys 
625                 630             


<210>  69
<211>  676
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F18-APT89.38, geranyl diphosphate synthase, soluble 
       aromatic prenyltransferase fusion protein

<400>  69

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Gly Gly Ser Leu Glu Asp 
            340                 345                 350         


Pro Ala Val Trp Glu Ala Gly Lys Val Val Ala Lys Gly Val Gly Thr 
        355                 360                 365             


Ala Asp Ile Thr Ala Thr Thr Ser Asn Gly Leu Ile Ala Ser Ser Glu 
    370                 375                 380                 


Glu Ala Asp Asn Ala Ala Thr Ser Met Asp Glu Val Tyr Ala Ala Val 
385                 390                 395                 400 


Glu Arg Thr Ser Arg Leu Leu Asp Val Pro Cys Ser Pro Asp Arg Phe 
                405                 410                 415     


Glu Pro Val Trp Lys Ala Phe Gly Asp Gln Leu Pro Asp Ser His Leu 
            420                 425                 430         


Val Phe Ser Met Ala Ala Gly Glu Ala His Arg Gly Glu Leu Asp Phe 
        435                 440                 445             


Asp Phe Ser Leu Arg Pro Glu Gly Ala Asp Pro Tyr Thr Thr Ala Leu 
    450                 455                 460                 


Glu His Gly Phe Ile Glu Pro Thr Asp His Pro Val Gly Ser Val Leu 
465                 470                 475                 480 


Ala Glu Val Asn Lys Arg Cys Glu Ile Ala Ser Tyr Gly Val Glu Tyr 
                485                 490                 495     


Gly Val Val Gly Gly Phe Lys Lys Ser Tyr Ala Phe Phe Pro Leu Asp 
            500                 505                 510         


Asp Phe Pro Pro Leu Ala Glu Phe Ala Arg Ile Pro Ser Val Pro Pro 
        515                 520                 525             


Cys Leu Ala Gly His Val Asp Thr Leu Thr Arg Leu Gly Leu Asp Asp 
    530                 535                 540                 


Lys Val Ser Ala Ile Gly Val Asn Tyr Arg Lys Asn Thr Leu Asn Val 
545                 550                 555                 560 


Tyr Leu Ala Ala Ser Ala Val Ala Thr Asp Asp Lys Leu Ala Leu Leu 
                565                 570                 575     


Arg Ala Phe Gly Tyr Pro Glu Pro Asp Ala Arg Val Arg Gln Phe Ile 
            580                 585                 590         


Glu Arg Ser Phe Arg Leu Tyr Pro Thr Phe Asn Trp Asp Ser Ser Ala 
        595                 600                 605             


Ala Glu Arg Ile Cys Phe Ala Val His Thr Gln Gln Pro Gly Glu Leu 
    610                 615                 620                 


Pro Ala Pro His Asp Glu Pro Thr Glu Ala Phe Ala Arg Glu Val Pro 
625                 630                 635                 640 


His Val Tyr Glu Gly Gly Arg Glu Phe Val Ser Gly Val Ala Leu Ala 
                645                 650                 655     


Pro Ser Gly Ala Ala Tyr Tyr Lys Leu Ala Ala Glu Tyr Gln Lys Glu 
            660                 665                 670         


Arg Arg Cys Leu 
        675     


<210>  70
<211>  676
<212>  PRT
<213>  Artificial

<220>
<223>  APT89.38-F18-GPS1.1, soluble aromatic prenyltransferase, geranyl 
       diphosphate synthase fusion protein

<400>  70

Met Asp Glu Val Tyr Ala Ala Val Glu Arg Thr Ser Arg Leu Leu Asp 
1               5                   10                  15      


Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp Lys Ala Phe Gly 
            20                  25                  30          


Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met Ala Ala Gly Glu 
        35                  40                  45              


Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu Arg Pro Glu Gly 
    50                  55                  60                  


Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe Ile Glu Pro Thr 
65                  70                  75                  80  


Asp His Pro Val Gly Ser Val Leu Ala Glu Val Asn Lys Arg Cys Glu 
                85                  90                  95      


Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly Gly Phe Lys Lys 
            100                 105                 110         


Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro Leu Ala Glu Phe 
        115                 120                 125             


Ala Arg Ile Pro Ser Val Pro Pro Cys Leu Ala Gly His Val Asp Thr 
    130                 135                 140                 


Leu Thr Arg Leu Gly Leu Asp Asp Lys Val Ser Ala Ile Gly Val Asn 
145                 150                 155                 160 


Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala Ser Ala Val Ala 
                165                 170                 175     


Thr Asp Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly Tyr Pro Glu Pro 
            180                 185                 190         


Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe Arg Leu Tyr Pro 
        195                 200                 205             


Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile Cys Phe Ala Val 
    210                 215                 220                 


His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His Asp Glu Pro Thr 
225                 230                 235                 240 


Glu Ala Phe Ala Arg Glu Val Pro His Val Tyr Glu Gly Gly Arg Glu 
                245                 250                 255     


Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala Ala Tyr Tyr Lys 
            260                 265                 270         


Leu Ala Ala Glu Tyr Gln Lys Glu Arg Arg Cys Leu Gly Gly Gly Gly 
        275                 280                 285             


Ser Leu Glu Asp Pro Ala Val Trp Glu Ala Gly Lys Val Val Ala Lys 
    290                 295                 300                 


Gly Val Gly Thr Ala Asp Ile Thr Ala Thr Thr Ser Asn Gly Leu Ile 
305                 310                 315                 320 


Ala Ser Ser Glu Glu Ala Asp Asn Ala Ala Thr Ser Met Ser Lys Ala 
                325                 330                 335     


Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu Leu Val Gln Leu 
            340                 345                 350         


Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln Trp Phe Ser Asp 
        355                 360                 365             


Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn Arg Gly Leu Ser 
    370                 375                 380                 


Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys Glu Leu Asp Asp 
385                 390                 395                 400 


Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu Ile Glu Leu Leu 
                405                 410                 415     


Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp Glu Ser Lys Thr 
            420                 425                 430         


Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys Val Gly Met Ile 
        435                 440                 445             


Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile Tyr Ile Leu Leu 
    450                 455                 460                 


Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp Leu Val Glu Leu 
465                 470                 475                 480 


Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln Leu Val Asp Leu 
                485                 490                 495     


Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg Phe Ser Leu Asp 
            500                 505                 510         


Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr Tyr Ser Phe Tyr 
        515                 520                 525             


Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile Thr Asn Pro Lys 
    530                 535                 540                 


Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe 
545                 550                 555                 560 


Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp Pro Glu Phe Ile 
                565                 570                 575     


Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val 
            580                 585                 590         


Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg Gln Ile Leu Glu 
        595                 600                 605             


Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu Val Ile Lys Lys 
    610                 615                 620                 


Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu Asp Tyr Glu Glu 
625                 630                 635                 640 


Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln Val Asp Glu Ser 
                645                 650                 655     


Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu Ala Lys Ile Tyr 
            660                 665                 670         


Lys Arg Gln Lys 
        675     


<210>  71
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.1 (recombinant membrane-bound prenyltransferase)

<400>  71

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Phe Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  72
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.2 (recombinant membrane-bound prenyltransferase)

<400>  72

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Met Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  73
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.3 (recombinant membrane-bound prenyltransferase)

<400>  73

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  74
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.4 (recombinant membrane-bound prenyltransferase)

<400>  74

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Ala Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  75
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.5 (recombinant membrane-bound prenyltransferase)

<400>  75

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Thr Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  76
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.6 (recombinant membrane-bound prenyltransferase)

<400>  76

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Val Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  77
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.7 (recombinant membrane-bound prenyltransferase)

<400>  77

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ala Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  78
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.8 (recombinant membrane-bound prenyltransferase)

<400>  78

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Gly Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  79
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.9 (recombinant membrane-bound prenyltransferase)

<400>  79

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ser Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  80
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.10 (recombinant membrane-bound prenyltransferase)

<400>  80

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Met Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  81
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.11 (recombinant membrane-bound prenyltransferase)

<400>  81

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Val Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  82
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.12 (recombinant membrane-bound prenyltransferase)

<400>  82

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Glu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  83
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.13 (recombinant membrane-bound prenyltransferase)

<400>  83

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ala Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  84
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.14 (recombinant membrane-bound prenyltransferase)

<400>  84

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Gly Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  85
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.15 (recombinant membrane-bound prenyltransferase)

<400>  85

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Val Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  86
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.16 (recombinant membrane-bound prenyltransferase)

<400>  86

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Gly Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  87
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.17 (recombinant membrane-bound prenyltransferase)

<400>  87

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Gln Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  88
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.18 (recombinant membrane-bound prenyltransferase)

<400>  88

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Ala Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  89
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.19 (recombinant membrane-bound prenyltransferase)

<400>  89

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ala Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  90
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.20 (recombinant membrane-bound prenyltransferase)

<400>  90

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Gly Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  91
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  MPT21.22 (recombinant membrane-bound prenyltransferase)

<400>  91

Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr 
1               5                   10                  15      


Cys Trp Lys Leu Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile 
            20                  25                  30          


Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile 
        35                  40                  45              


Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu 
    50                  55                  60                  


Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp 
65                  70                  75                  80  


Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met 
                85                  90                  95      


Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly 
            100                 105                 110         


Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile 
        115                 120                 125             


Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile 
    130                 135                 140                 


Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser 
145                 150                 155                 160 


His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu 
                165                 170                 175     


Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe 
            180                 185                 190         


Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp 
        195                 200                 205             


Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu 
    210                 215                 220                 


Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn 
225                 230                 235                 240 


Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn 
                245                 250                 255     


Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile 
            260                 265                 270         


Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser 
        275                 280                 285             


Arg Gln Phe Phe Glu Phe Leu Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe 
    290                 295                 300                 


Val Tyr Val Phe Ile 
305                 


<210>  92
<211>  832
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-PKC1.1-F11-MPT4, geranyl diphosphate synthase, 
       polyketide cyclase, membrane-bound prenyltransferase fusion 
       protein

<400>  92

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr Glu 
385                 390                 395                 400 


Ala Gln Lys Glu Glu Phe Phe Lys Thr Phe Val Asn Leu Val Asn Ile 
                405                 410                 415     


Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln Lys 
            420                 425                 430         


Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu Ser 
        435                 440                 445             


Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly Phe 
    450                 455                 460                 


Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp Tyr 
465                 470                 475                 480 


Thr Pro Arg Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                485                 490                 495     


Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser 
        515                 520                 525             


Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln 
    530                 535                 540                 


Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe 
545                 550                 555                 560 


Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met 
                565                 570                 575     


Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe 
            580                 585                 590         


Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn 
        595                 600                 605             


Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala 
    610                 615                 620                 


Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile 
625                 630                 635                 640 


Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile 
                645                 650                 655     


Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr 
            660                 665                 670         


Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala 
        675                 680                 685             


Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val 
    690                 695                 700                 


Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly 
705                 710                 715                 720 


Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala 
                725                 730                 735     


Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met 
            740                 745                 750         


Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile 
        755                 760                 765             


Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile 
    770                 775                 780                 


Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu 
785                 790                 795                 800 


Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu 
                805                 810                 815     


Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
            820                 825                 830         


<210>  93
<211>  832
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-PKC1.1-F11-MPT4.1, geranyl diphosphate synthase, 
       polyketide cyclase, point mutant membrane-bound prenyltransferase
       fusion protein

<400>  93

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr Glu 
385                 390                 395                 400 


Ala Gln Lys Glu Glu Phe Phe Lys Thr Phe Val Asn Leu Val Asn Ile 
                405                 410                 415     


Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln Lys 
            420                 425                 430         


Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu Ser 
        435                 440                 445             


Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly Phe 
    450                 455                 460                 


Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp Tyr 
465                 470                 475                 480 


Thr Pro Arg Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                485                 490                 495     


Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser 
        515                 520                 525             


Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln 
    530                 535                 540                 


Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe 
545                 550                 555                 560 


Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met 
                565                 570                 575     


Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe 
            580                 585                 590         


Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn 
        595                 600                 605             


Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala 
    610                 615                 620                 


Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile 
625                 630                 635                 640 


Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile 
                645                 650                 655     


Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr 
            660                 665                 670         


Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala 
        675                 680                 685             


Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val 
    690                 695                 700                 


Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly 
705                 710                 715                 720 


Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala 
                725                 730                 735     


Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met 
            740                 745                 750         


Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile 
        755                 760                 765             


Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile 
    770                 775                 780                 


Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu 
785                 790                 795                 800 


Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu 
                805                 810                 815     


Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
            820                 825                 830         


<210>  94
<211>  832
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-PKC1.1-F11-MPT21.3, geranyl diphosphate synthase, 
       polyketide cyclase, recombinant membrane-bound prenyltransferase 
       fusion protein

<400>  94

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr Glu 
385                 390                 395                 400 


Ala Gln Lys Glu Glu Phe Phe Lys Thr Phe Val Asn Leu Val Asn Ile 
                405                 410                 415     


Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln Lys 
            420                 425                 430         


Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu Ser 
        435                 440                 445             


Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly Phe 
    450                 455                 460                 


Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp Tyr 
465                 470                 475                 480 


Thr Pro Arg Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                485                 490                 495     


Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser 
        515                 520                 525             


Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln 
    530                 535                 540                 


Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe 
545                 550                 555                 560 


Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile Ser Trp Gly Leu Met 
                565                 570                 575     


Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe 
            580                 585                 590         


Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn 
        595                 600                 605             


Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala 
    610                 615                 620                 


Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile 
625                 630                 635                 640 


Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile 
                645                 650                 655     


Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Asn 
            660                 665                 670         


Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala 
        675                 680                 685             


Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu Gly Leu Pro Phe Glu 
    690                 695                 700                 


Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe Met Thr Val Met Gly 
705                 710                 715                 720 


Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala 
                725                 730                 735     


Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met 
            740                 745                 750         


Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Val Ala Ala Ile 
        755                 760                 765             


Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn Ser Asn Val Met Leu 
    770                 775                 780                 


Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu 
785                 790                 795                 800 


Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu 
                805                 810                 815     


Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
            820                 825                 830         


<210>  95
<211>  846
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-PKC4.33-F11-MPT4.1, geranyl diphosphate synthase, 
       polyketide cyclase, point mutant membrane-bound prenyltransferase
       fusion protein

<400>  95

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Gly Glu Ala Asn Lys Gly Val Val Lys His Val Ile Ile Leu Lys Phe 
385                 390                 395                 400 


Lys Glu Gly Ile Thr Glu Ala Gln Lys Glu Glu Met Phe Lys Thr Tyr 
                405                 410                 415     


Val Asn Leu Val Asn Leu Val Pro Ala Met Lys Ala Val Gln Trp Gly 
            420                 425                 430         


Lys Leu Glu Val Asn Asn Lys Leu Gly Asn Gly Gly Tyr Thr His Ile 
        435                 440                 445             


Val Glu Ser Thr Phe Glu Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile 
    450                 455                 460                 


His Pro Ala His Val Gly Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu 
465                 470                 475                 480 


Lys Leu Leu Ile Phe Asp Tyr Thr Pro Thr Ile Val Leu Pro Asn Ser 
                485                 490                 495     


Ser Tyr Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser Ile Ala 
    530                 535                 540                 


Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro 
545                 550                 555                 560 


Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Arg 
                565                 570                 575     


Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp Lys 
            580                 585                 590         


Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala 
        595                 600                 605             


Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro 
    610                 615                 620                 


Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile 
625                 630                 635                 640 


Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu 
                645                 650                 655     


Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala 
            660                 665                 670         


Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe 
        675                 680                 685             


Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr 
    690                 695                 700                 


Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg 
705                 710                 715                 720 


Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr 
                725                 730                 735     


Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr 
            740                 745                 750         


Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe 
        755                 760                 765             


Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile 
    770                 775                 780                 


Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser 
785                 790                 795                 800 


His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala 
                805                 810                 815     


Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile 
            820                 825                 830         


Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
        835                 840                 845     


<210>  96
<211>  846
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-PKC4.33-F11-MPT21.3, geranyl diphosphate synthase, 
       polyketide cyclase, recombinant membrane-bound prenyltransferase 
       fusion protein

<400>  96

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Gly Glu Ala Asn Lys Gly Val Val Lys His Val Ile Ile Leu Lys Phe 
385                 390                 395                 400 


Lys Glu Gly Ile Thr Glu Ala Gln Lys Glu Glu Met Phe Lys Thr Tyr 
                405                 410                 415     


Val Asn Leu Val Asn Leu Val Pro Ala Met Lys Ala Val Gln Trp Gly 
            420                 425                 430         


Lys Leu Glu Val Asn Asn Lys Leu Gly Asn Gly Gly Tyr Thr His Ile 
        435                 440                 445             


Val Glu Ser Thr Phe Glu Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile 
    450                 455                 460                 


His Pro Ala His Val Gly Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu 
465                 470                 475                 480 


Lys Leu Leu Ile Phe Asp Tyr Thr Pro Thr Ile Val Leu Pro Asn Ser 
                485                 490                 495     


Ser Tyr Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser Ile Ala 
    530                 535                 540                 


Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro 
545                 550                 555                 560 


Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Lys 
                565                 570                 575     


Glu Leu Leu His Asn Thr Asn Leu Ile Ser Trp Gly Leu Met Trp Lys 
            580                 585                 590         


Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala 
        595                 600                 605             


Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro 
    610                 615                 620                 


Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile 
625                 630                 635                 640 


Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu 
                645                 650                 655     


Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala 
            660                 665                 670         


Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Asn Pro Ser 
        675                 680                 685             


Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr 
    690                 695                 700                 


Ser Tyr Tyr Ala Ser Arg Ala Ala Leu Gly Leu Pro Phe Glu Leu Arg 
705                 710                 715                 720 


Pro Ser Phe Thr Phe Leu Leu Ala Phe Met Thr Val Met Gly Met Thr 
                725                 730                 735     


Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr 
            740                 745                 750         


Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe 
        755                 760                 765             


Val Val Ser Gly Val Leu Leu Leu Asn Tyr Val Ala Ala Ile Leu Ala 
    770                 775                 780                 


Gly Ile Ile Trp Pro Gln Ala Phe Asn Ser Asn Val Met Leu Leu Ser 
785                 790                 795                 800 


His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala 
                805                 810                 815     


Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile 
            820                 825                 830         


Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
        835                 840                 845     


<210>  97
<211>  768
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-PKC4.33-MPT4.1, geranyl diphosphate synthase, polyketide 
       cyclase, point mutant membrane-bound prenyltransferase fusion 
       protein

<400>  97

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Met Gly Glu Ala Asn Lys Gly Val 
            340                 345                 350         


Val Lys His Val Ile Ile Leu Lys Phe Lys Glu Gly Ile Thr Glu Ala 
        355                 360                 365             


Gln Lys Glu Glu Met Phe Lys Thr Tyr Val Asn Leu Val Asn Leu Val 
    370                 375                 380                 


Pro Ala Met Lys Ala Val Gln Trp Gly Lys Leu Glu Val Asn Asn Lys 
385                 390                 395                 400 


Leu Gly Asn Gly Gly Tyr Thr His Ile Val Glu Ser Thr Phe Glu Ser 
                405                 410                 415     


Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly Phe 
            420                 425                 430         


Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp Tyr 
        435                 440                 445             


Thr Pro Thr Ile Val Leu Pro Asn Ser Ser Tyr Met Ser Asp Asn Ser 
    450                 455                 460                 


Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln 
465                 470                 475                 480 


Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe 
                485                 490                 495     


Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met 
            500                 505                 510         


Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe 
        515                 520                 525             


Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn 
    530                 535                 540                 


Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala 
545                 550                 555                 560 


Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile 
                565                 570                 575     


Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile 
            580                 585                 590         


Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr 
        595                 600                 605             


Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala 
    610                 615                 620                 


Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val 
625                 630                 635                 640 


Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly 
                645                 650                 655     


Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala 
            660                 665                 670         


Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met 
        675                 680                 685             


Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile 
    690                 695                 700                 


Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile 
705                 710                 715                 720 


Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu 
                725                 730                 735     


Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu 
            740                 745                 750         


Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
        755                 760                 765             


<210>  98
<211>  768
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-PKC4.33-MPT21.3, geranyl diphosphate synthase, polyketide 
       cyclase, recombinant membrane-bound prenyltransferase fusion 
       protein

<400>  98

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Met Gly Glu Ala Asn Lys Gly Val 
            340                 345                 350         


Val Lys His Val Ile Ile Leu Lys Phe Lys Glu Gly Ile Thr Glu Ala 
        355                 360                 365             


Gln Lys Glu Glu Met Phe Lys Thr Tyr Val Asn Leu Val Asn Leu Val 
    370                 375                 380                 


Pro Ala Met Lys Ala Val Gln Trp Gly Lys Leu Glu Val Asn Asn Lys 
385                 390                 395                 400 


Leu Gly Asn Gly Gly Tyr Thr His Ile Val Glu Ser Thr Phe Glu Ser 
                405                 410                 415     


Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly Phe 
            420                 425                 430         


Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp Tyr 
        435                 440                 445             


Thr Pro Thr Ile Val Leu Pro Asn Ser Ser Tyr Met Ser Asp Asn Ser 
    450                 455                 460                 


Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln 
465                 470                 475                 480 


Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe 
                485                 490                 495     


Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile Ser Trp Gly Leu Met 
            500                 505                 510         


Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe 
        515                 520                 525             


Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn 
    530                 535                 540                 


Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala 
545                 550                 555                 560 


Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile 
                565                 570                 575     


Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile 
            580                 585                 590         


Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Asn 
        595                 600                 605             


Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala 
    610                 615                 620                 


Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu Gly Leu Pro Phe Glu 
625                 630                 635                 640 


Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe Met Thr Val Met Gly 
                645                 650                 655     


Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala 
            660                 665                 670         


Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met 
        675                 680                 685             


Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Val Ala Ala Ile 
    690                 695                 700                 


Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn Ser Asn Val Met Leu 
705                 710                 715                 720 


Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu 
                725                 730                 735     


Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu 
            740                 745                 750         


Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
        755                 760                 765             


<210>  99
<211>  832
<212>  PRT
<213>  Artificial

<220>
<223>  PKC1.1-F11-GPS1.1-F11-MPT4.1, geranyl diphosphate synthase, 
       polyketide cyclase, point mutant membrane-bound prenyltransferase
       fusion protein

<400>  99

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Phe Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala 
            100                 105                 110         


Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Lys Ala 
    130                 135                 140                 


Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu Leu Val Gln Leu 
145                 150                 155                 160 


Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln Trp Phe Ser Asp 
                165                 170                 175     


Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn Arg Gly Leu Ser 
            180                 185                 190         


Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys Glu Leu Asp Asp 
        195                 200                 205             


Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu Ile Glu Leu Leu 
    210                 215                 220                 


Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp Glu Ser Lys Thr 
225                 230                 235                 240 


Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys Val Gly Met Ile 
                245                 250                 255     


Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile Tyr Ile Leu Leu 
            260                 265                 270         


Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp Leu Val Glu Leu 
        275                 280                 285             


Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln Leu Val Asp Leu 
    290                 295                 300                 


Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg Phe Ser Leu Asp 
305                 310                 315                 320 


Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr Tyr Ser Phe Tyr 
                325                 330                 335     


Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile Thr Asn Pro Lys 
            340                 345                 350         


Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe 
        355                 360                 365             


Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp Pro Glu Phe Ile 
    370                 375                 380                 


Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val 
385                 390                 395                 400 


Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg Gln Ile Leu Glu 
                405                 410                 415     


Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu Val Ile Lys Lys 
            420                 425                 430         


Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu Asp Tyr Glu Glu 
        435                 440                 445             


Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln Val Asp Glu Ser 
    450                 455                 460                 


Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu Ala Lys Ile Tyr 
465                 470                 475                 480 


Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                485                 490                 495     


Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser 
        515                 520                 525             


Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln 
    530                 535                 540                 


Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe 
545                 550                 555                 560 


Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met 
                565                 570                 575     


Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe 
            580                 585                 590         


Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn 
        595                 600                 605             


Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala 
    610                 615                 620                 


Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile 
625                 630                 635                 640 


Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile 
                645                 650                 655     


Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr 
            660                 665                 670         


Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala 
        675                 680                 685             


Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val 
    690                 695                 700                 


Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly 
705                 710                 715                 720 


Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala 
                725                 730                 735     


Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met 
            740                 745                 750         


Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile 
        755                 760                 765             


Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile 
    770                 775                 780                 


Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu 
785                 790                 795                 800 


Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu 
                805                 810                 815     


Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
            820                 825                 830         


<210>  100
<211>  846
<212>  PRT
<213>  Artificial

<220>
<223>  PKC4.33-F11-GPS1.1-F11-MPT4.1, polyketide cyclase, geranyl 
       diphosphate synthase, point mutant prenyltransferase fusion 
       protein

<400>  100

Met Gly Glu Ala Asn Lys Gly Val Val Lys His Val Ile Ile Leu Lys 
1               5                   10                  15      


Phe Lys Glu Gly Ile Thr Glu Ala Gln Lys Glu Glu Met Phe Lys Thr 
            20                  25                  30          


Tyr Val Asn Leu Val Asn Leu Val Pro Ala Met Lys Ala Val Gln Trp 
        35                  40                  45              


Gly Lys Leu Glu Val Asn Asn Lys Leu Gly Asn Gly Gly Tyr Thr His 
    50                  55                  60                  


Ile Val Glu Ser Thr Phe Glu Ser Val Glu Thr Ile Gln Asp Tyr Ile 
65                  70                  75                  80  


Ile His Pro Ala His Val Gly Phe Gly Asp Val Tyr Arg Ser Phe Trp 
                85                  90                  95      


Glu Lys Leu Leu Ile Phe Asp Tyr Thr Pro Thr Ile Val Leu Pro Asn 
            100                 105                 110         


Ser Ser Tyr Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
        115                 120                 125             


Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Lys Ala Lys Phe 
145                 150                 155                 160 


Glu Ser Val Phe Pro Arg Ile Ser Glu Glu Leu Val Gln Leu Leu Arg 
                165                 170                 175     


Asp Glu Gly Leu Pro Gln Asp Ala Val Gln Trp Phe Ser Asp Ser Leu 
            180                 185                 190         


Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val 
        195                 200                 205             


Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys Glu Leu Asp Asp Glu Glu 
    210                 215                 220                 


Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu Ile Glu Leu Leu Gln Ala 
225                 230                 235                 240 


Phe Trp Leu Val Ser Asp Asp Ile Met Asp Glu Ser Lys Thr Arg Arg 
                245                 250                 255     


Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys Val Gly Met Ile Ala Ile 
            260                 265                 270         


Trp Asp Ala Phe Met Leu Glu Ser Gly Ile Tyr Ile Leu Leu Lys Lys 
        275                 280                 285             


His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp Leu Val Glu Leu Phe His 
    290                 295                 300                 


Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln Leu Val Asp Leu Leu Thr 
305                 310                 315                 320 


Ala Pro Glu Asp Glu Val Asp Leu Asn Arg Phe Ser Leu Asp Lys His 
                325                 330                 335     


Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro 
            340                 345                 350         


Val Val Leu Ala Met Tyr Val Ala Gly Ile Thr Asn Pro Lys Asp Leu 
        355                 360                 365             


Gln Gln Ala Met Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Val 
    370                 375                 380                 


Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp Pro Glu Phe Ile Gly Lys 
385                 390                 395                 400 


Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Asn Lys 
                405                 410                 415     


Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg Gln Ile Leu Glu Asp Asn 
            420                 425                 430         


Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu Val Ile Lys Lys Leu Tyr 
        435                 440                 445             


Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu Asp Tyr Glu Glu Glu Val 
    450                 455                 460                 


Val Gly Asp Ile Lys Lys Lys Ile Glu Gln Val Asp Glu Ser Arg Gly 
465                 470                 475                 480 


Phe Lys Lys Glu Val Leu Asn Ala Phe Leu Ala Lys Ile Tyr Lys Arg 
                485                 490                 495     


Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser Ile Ala 
    530                 535                 540                 


Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro 
545                 550                 555                 560 


Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Arg 
                565                 570                 575     


Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu Met Trp Lys 
            580                 585                 590         


Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala 
        595                 600                 605             


Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro 
    610                 615                 620                 


Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile 
625                 630                 635                 640 


Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu 
                645                 650                 655     


Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala 
            660                 665                 670         


Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Tyr Pro Phe 
        675                 680                 685             


Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr 
    690                 695                 700                 


Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe Val Trp Arg 
705                 710                 715                 720 


Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met Gly Met Thr 
                725                 730                 735     


Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr 
            740                 745                 750         


Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe 
        755                 760                 765             


Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser Ile Ser Ile 
    770                 775                 780                 


Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met Ile Leu Ser 
785                 790                 795                 800 


His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala 
                805                 810                 815     


Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile 
            820                 825                 830         


Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
        835                 840                 845     


<210>  101
<211>  807
<212>  PRT
<213>  Artificial

<220>
<223>  PKC4.33-GPS1.1-F11-MPT4.1, polyketide cyclase, geranyl 
       diphosphate synthase, point mutant prenyltransferase fusion 
       protein

<400>  101

Met Gly Glu Ala Asn Lys Gly Val Val Lys His Val Ile Ile Leu Lys 
1               5                   10                  15      


Phe Lys Glu Gly Ile Thr Glu Ala Gln Lys Glu Glu Met Phe Lys Thr 
            20                  25                  30          


Tyr Val Asn Leu Val Asn Leu Val Pro Ala Met Lys Ala Val Gln Trp 
        35                  40                  45              


Gly Lys Leu Glu Val Asn Asn Lys Leu Gly Asn Gly Gly Tyr Thr His 
    50                  55                  60                  


Ile Val Glu Ser Thr Phe Glu Ser Val Glu Thr Ile Gln Asp Tyr Ile 
65                  70                  75                  80  


Ile His Pro Ala His Val Gly Phe Gly Asp Val Tyr Arg Ser Phe Trp 
                85                  90                  95      


Glu Lys Leu Leu Ile Phe Asp Tyr Thr Pro Thr Ile Val Leu Pro Asn 
            100                 105                 110         


Ser Ser Tyr Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile 
        115                 120                 125             


Ser Glu Glu Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp 
    130                 135                 140                 


Ala Val Gln Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly 
145                 150                 155                 160 


Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr 
                165                 170                 175     


Gly Lys Lys Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu 
            180                 185                 190         


Gly Trp Leu Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp 
        195                 200                 205             


Ile Met Asp Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu 
    210                 215                 220                 


Lys Pro Lys Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu 
225                 230                 235                 240 


Ser Gly Ile Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr 
                245                 250                 255     


Tyr Ile Asp Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu 
            260                 265                 270         


Leu Gly Gln Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp 
        275                 280                 285             


Leu Asn Arg Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys 
    290                 295                 300                 


Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val 
305                 310                 315                 320 


Ala Gly Ile Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu 
                325                 330                 335     


Ile Pro Leu Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn 
            340                 345                 350         


Phe Gly Asp Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp 
        355                 360                 365             


Asn Lys Cys Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro 
    370                 375                 380                 


Glu Gln Arg Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser 
385                 390                 395                 400 


Lys Glu Leu Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln 
                405                 410                 415     


Asp Tyr Leu Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys 
            420                 425                 430         


Ile Glu Gln Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn 
        435                 440                 445             


Ala Phe Leu Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala 
    450                 455                 460                 


Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly 
            500                 505                 510         


His Thr Cys Trp Lys Leu Gln Arg Pro Tyr Ala Val Lys Gly Met Ile 
        515                 520                 525             


Ser Ile Ala Cys Gly Leu Phe Gly Arg Glu Leu Phe Asn Asn Arg His 
    530                 535                 540                 


Leu Phe Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro 
545                 550                 555                 560 


Ile Leu Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp 
                565                 570                 575     


Val Asp Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly 
            580                 585                 590         


Glu Met Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu 
        595                 600                 605             


Thr Gly Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val 
    610                 615                 620                 


Phe Ile Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro 
625                 630                 635                 640 


Pro Ile Arg Trp Lys Gln Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile 
                645                 650                 655     


Ser Ser His Val Gly Leu Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser 
            660                 665                 670         


Ala Leu Gly Leu Pro Phe Val Trp Arg Pro Ala Phe Ser Phe Ile Ile 
        675                 680                 685             


Ala Phe Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile 
    690                 695                 700                 


Ser Asp Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr 
705                 710                 715                 720 


Lys Leu Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu 
                725                 730                 735     


Leu Asn Tyr Leu Val Ser Ile Ser Ile Gly Ile Ile Trp Pro Gln Val 
            740                 745                 750         


Phe Lys Ser Asn Ile Met Ile Leu Ser His Ala Ile Leu Ala Phe Cys 
        755                 760                 765             


Leu Ile Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala 
    770                 775                 780                 


Pro Ser Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu 
785                 790                 795                 800 


Tyr Phe Val Tyr Val Phe Ile 
                805         


<210>  102
<211>  832
<212>  PRT
<213>  Artificial

<220>
<223>  PKC1.1-F11-GPS1.1-F11-MPT21.3, polyketide cyclase, geranyl 
       diphosphate synthase, recombinant membrane-bound 
       prenyltransferase fusion protein

<400>  102

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Phe Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala 
            100                 105                 110         


Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Lys Ala 
    130                 135                 140                 


Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu Leu Val Gln Leu 
145                 150                 155                 160 


Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln Trp Phe Ser Asp 
                165                 170                 175     


Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn Arg Gly Leu Ser 
            180                 185                 190         


Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys Glu Leu Asp Asp 
        195                 200                 205             


Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu Ile Glu Leu Leu 
    210                 215                 220                 


Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp Glu Ser Lys Thr 
225                 230                 235                 240 


Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys Val Gly Met Ile 
                245                 250                 255     


Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile Tyr Ile Leu Leu 
            260                 265                 270         


Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp Leu Val Glu Leu 
        275                 280                 285             


Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln Leu Val Asp Leu 
    290                 295                 300                 


Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg Phe Ser Leu Asp 
305                 310                 315                 320 


Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr Tyr Ser Phe Tyr 
                325                 330                 335     


Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile Thr Asn Pro Lys 
            340                 345                 350         


Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe 
        355                 360                 365             


Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp Pro Glu Phe Ile 
    370                 375                 380                 


Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val 
385                 390                 395                 400 


Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg Gln Ile Leu Glu 
                405                 410                 415     


Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu Val Ile Lys Lys 
            420                 425                 430         


Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu Asp Tyr Glu Glu 
        435                 440                 445             


Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln Val Asp Glu Ser 
    450                 455                 460                 


Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu Ala Lys Ile Tyr 
465                 470                 475                 480 


Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                485                 490                 495     


Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser 
        515                 520                 525             


Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln 
    530                 535                 540                 


Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe 
545                 550                 555                 560 


Gly Lys Glu Leu Leu His Asn Thr Asn Leu Ile Ser Trp Gly Leu Met 
                565                 570                 575     


Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe 
            580                 585                 590         


Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn 
        595                 600                 605             


Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala 
    610                 615                 620                 


Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile 
625                 630                 635                 640 


Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile 
                645                 650                 655     


Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Asn 
            660                 665                 670         


Pro Ser Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala 
        675                 680                 685             


Phe Thr Ser Tyr Tyr Ala Ser Arg Ala Ala Leu Gly Leu Pro Phe Glu 
    690                 695                 700                 


Leu Arg Pro Ser Phe Thr Phe Leu Leu Ala Phe Met Thr Val Met Gly 
705                 710                 715                 720 


Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala 
                725                 730                 735     


Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met 
            740                 745                 750         


Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Val Ala Ala Ile 
        755                 760                 765             


Leu Ala Gly Ile Ile Trp Pro Gln Ala Phe Asn Ser Asn Val Met Leu 
    770                 775                 780                 


Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu 
785                 790                 795                 800 


Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu 
                805                 810                 815     


Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
            820                 825                 830         


<210>  103
<211>  846
<212>  PRT
<213>  Artificial

<220>
<223>  PKC4.33-F11-GPS1.1-F11-MPT21.3, polyketide cyclase, geranyl 
       diphosphate synthase, recombinant membrane-bound 
       prenyltransferase fusion protein

<400>  103

Met Gly Glu Ala Asn Lys Gly Val Val Lys His Val Ile Ile Leu Lys 
1               5                   10                  15      


Phe Lys Glu Gly Ile Thr Glu Ala Gln Lys Glu Glu Met Phe Lys Thr 
            20                  25                  30          


Tyr Val Asn Leu Val Asn Leu Val Pro Ala Met Lys Ala Val Gln Trp 
        35                  40                  45              


Gly Lys Leu Glu Val Asn Asn Lys Leu Gly Asn Gly Gly Tyr Thr His 
    50                  55                  60                  


Ile Val Glu Ser Thr Phe Glu Ser Val Glu Thr Ile Gln Asp Tyr Ile 
65                  70                  75                  80  


Ile His Pro Ala His Val Gly Phe Gly Asp Val Tyr Arg Ser Phe Trp 
                85                  90                  95      


Glu Lys Leu Leu Ile Phe Asp Tyr Thr Pro Thr Ile Val Leu Pro Asn 
            100                 105                 110         


Ser Ser Tyr Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
        115                 120                 125             


Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Lys Ala Lys Phe 
145                 150                 155                 160 


Glu Ser Val Phe Pro Arg Ile Ser Glu Glu Leu Val Gln Leu Leu Arg 
                165                 170                 175     


Asp Glu Gly Leu Pro Gln Asp Ala Val Gln Trp Phe Ser Asp Ser Leu 
            180                 185                 190         


Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val 
        195                 200                 205             


Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys Glu Leu Asp Asp Glu Glu 
    210                 215                 220                 


Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu Ile Glu Leu Leu Gln Ala 
225                 230                 235                 240 


Phe Trp Leu Val Ser Asp Asp Ile Met Asp Glu Ser Lys Thr Arg Arg 
                245                 250                 255     


Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys Val Gly Met Ile Ala Ile 
            260                 265                 270         


Trp Asp Ala Phe Met Leu Glu Ser Gly Ile Tyr Ile Leu Leu Lys Lys 
        275                 280                 285             


His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp Leu Val Glu Leu Phe His 
    290                 295                 300                 


Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln Leu Val Asp Leu Leu Thr 
305                 310                 315                 320 


Ala Pro Glu Asp Glu Val Asp Leu Asn Arg Phe Ser Leu Asp Lys His 
                325                 330                 335     


Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro 
            340                 345                 350         


Val Val Leu Ala Met Tyr Val Ala Gly Ile Thr Asn Pro Lys Asp Leu 
        355                 360                 365             


Gln Gln Ala Met Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Val 
    370                 375                 380                 


Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp Pro Glu Phe Ile Gly Lys 
385                 390                 395                 400 


Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Leu Val Asn Lys 
                405                 410                 415     


Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg Gln Ile Leu Glu Asp Asn 
            420                 425                 430         


Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu Val Ile Lys Lys Leu Tyr 
        435                 440                 445             


Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu Asp Tyr Glu Glu Glu Val 
    450                 455                 460                 


Val Gly Asp Ile Lys Lys Lys Ile Glu Gln Val Asp Glu Ser Arg Gly 
465                 470                 475                 480 


Phe Lys Lys Glu Val Leu Asn Ala Phe Leu Ala Lys Ile Tyr Lys Arg 
                485                 490                 495     


Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn Ser Ile Ala 
    530                 535                 540                 


Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu Gln Arg Pro 
545                 550                 555                 560 


Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu Phe Gly Lys 
                565                 570                 575     


Glu Leu Leu His Asn Thr Asn Leu Ile Ser Trp Gly Leu Met Trp Lys 
            580                 585                 590         


Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe Phe Ala Ala 
        595                 600                 605             


Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile Asn Lys Pro 
    610                 615                 620                 


Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr Ala Trp Ile 
625                 630                 635                 640 


Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr Ile Lys Leu 
                645                 650                 655     


Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly Ile Phe Ala 
            660                 665                 670         


Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln Asn Pro Ser 
        675                 680                 685             


Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu Ala Phe Thr 
    690                 695                 700                 


Ser Tyr Tyr Ala Ser Arg Ala Ala Leu Gly Leu Pro Phe Glu Leu Arg 
705                 710                 715                 720 


Pro Ser Phe Thr Phe Leu Leu Ala Phe Met Thr Val Met Gly Met Thr 
                725                 730                 735     


Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp Ala Lys Tyr 
            740                 745                 750         


Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn Met Thr Phe 
        755                 760                 765             


Val Val Ser Gly Val Leu Leu Leu Asn Tyr Val Ala Ala Ile Leu Ala 
    770                 775                 780                 


Gly Ile Ile Trp Pro Gln Ala Phe Asn Ser Asn Val Met Leu Leu Ser 
785                 790                 795                 800 


His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg Glu Leu Ala 
                805                 810                 815     


Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe Glu Phe Ile 
            820                 825                 830         


Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe Ile 
        835                 840                 845     


<210>  104
<211>  807
<212>  PRT
<213>  Artificial

<220>
<223>  PKC4.33-GPS1.1-F11-MPT21.3, polyketide cyclase, geranyl 
       diphosphate synthase, recombinant membrane-bound 
       prenyltransferase fusion protein

<400>  104

Met Gly Glu Ala Asn Lys Gly Val Val Lys His Val Ile Ile Leu Lys 
1               5                   10                  15      


Phe Lys Glu Gly Ile Thr Glu Ala Gln Lys Glu Glu Met Phe Lys Thr 
            20                  25                  30          


Tyr Val Asn Leu Val Asn Leu Val Pro Ala Met Lys Ala Val Gln Trp 
        35                  40                  45              


Gly Lys Leu Glu Val Asn Asn Lys Leu Gly Asn Gly Gly Tyr Thr His 
    50                  55                  60                  


Ile Val Glu Ser Thr Phe Glu Ser Val Glu Thr Ile Gln Asp Tyr Ile 
65                  70                  75                  80  


Ile His Pro Ala His Val Gly Phe Gly Asp Val Tyr Arg Ser Phe Trp 
                85                  90                  95      


Glu Lys Leu Leu Ile Phe Asp Tyr Thr Pro Thr Ile Val Leu Pro Asn 
            100                 105                 110         


Ser Ser Tyr Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile 
        115                 120                 125             


Ser Glu Glu Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp 
    130                 135                 140                 


Ala Val Gln Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly 
145                 150                 155                 160 


Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr 
                165                 170                 175     


Gly Lys Lys Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu 
            180                 185                 190         


Gly Trp Leu Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp 
        195                 200                 205             


Ile Met Asp Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu 
    210                 215                 220                 


Lys Pro Lys Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu 
225                 230                 235                 240 


Ser Gly Ile Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr 
                245                 250                 255     


Tyr Ile Asp Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu 
            260                 265                 270         


Leu Gly Gln Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp 
        275                 280                 285             


Leu Asn Arg Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys 
    290                 295                 300                 


Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val 
305                 310                 315                 320 


Ala Gly Ile Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu 
                325                 330                 335     


Ile Pro Leu Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn 
            340                 345                 350         


Phe Gly Asp Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp 
        355                 360                 365             


Asn Lys Cys Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro 
    370                 375                 380                 


Glu Gln Arg Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser 
385                 390                 395                 400 


Lys Glu Leu Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln 
                405                 410                 415     


Asp Tyr Leu Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys 
            420                 425                 430         


Ile Glu Gln Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn 
        435                 440                 445             


Ala Phe Leu Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala 
    450                 455                 460                 


Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Met Ser Asp Asn Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly 
            500                 505                 510         


His Thr Cys Trp Lys Leu Gln Arg Pro Tyr Ala Val Lys Gly Met Ile 
        515                 520                 525             


Ser Ile Ala Cys Gly Leu Phe Gly Lys Glu Leu Leu His Asn Thr Asn 
    530                 535                 540                 


Leu Ile Ser Trp Gly Leu Met Trp Lys Ala Phe Phe Ala Leu Val Pro 
545                 550                 555                 560 


Ile Leu Ser Phe Asn Phe Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp 
                565                 570                 575     


Val Asp Ile Asp Arg Ile Asn Lys Pro Asp Leu Pro Leu Val Ser Gly 
            580                 585                 590         


Glu Met Ser Ile Glu Thr Ala Trp Ile Leu Ser Ile Ile Val Ala Leu 
        595                 600                 605             


Thr Gly Leu Ile Val Thr Ile Lys Leu Lys Ser Ala Pro Leu Phe Val 
    610                 615                 620                 


Phe Ile Tyr Ile Phe Gly Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro 
625                 630                 635                 640 


Pro Ile Arg Trp Lys Gln Asn Pro Ser Thr Asn Phe Leu Ile Thr Ile 
                645                 650                 655     


Ser Ser His Val Gly Leu Ala Phe Thr Ser Tyr Tyr Ala Ser Arg Ala 
            660                 665                 670         


Ala Leu Gly Leu Pro Phe Glu Leu Arg Pro Ser Phe Thr Phe Leu Leu 
        675                 680                 685             


Ala Phe Met Thr Val Met Gly Met Thr Ile Ala Phe Ala Lys Asp Ile 
    690                 695                 700                 


Ser Asp Ile Glu Gly Asp Ala Lys Tyr Gly Val Ser Thr Val Ala Thr 
705                 710                 715                 720 


Lys Leu Gly Ala Arg Asn Met Thr Phe Val Val Ser Gly Val Leu Leu 
                725                 730                 735     


Leu Asn Tyr Val Ala Ala Ile Leu Ala Gly Ile Ile Trp Pro Gln Ala 
            740                 745                 750         


Phe Asn Ser Asn Val Met Leu Leu Ser His Ala Ile Leu Ala Phe Cys 
        755                 760                 765             


Leu Ile Phe Gln Thr Arg Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala 
    770                 775                 780                 


Pro Ser Arg Gln Phe Phe Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu 
785                 790                 795                 800 


Tyr Phe Val Tyr Val Phe Ile 
                805         


<210>  105
<211>  660
<212>  PRT
<213>  Unknown

<220>
<223>  	HCS2 (hexanoyl-CoA synthetase)

<400>  105

Met Ala Ser Glu Glu Asn Asp Leu Val Phe Pro Ser Lys Glu Phe Ser 
1               5                   10                  15      


Gly Gln Ala Leu Val Ser Ser Pro Gln Gln Tyr Met Glu Met His Lys 
            20                  25                  30          


Arg Ser Met Asp Asp Pro Ala Ala Phe Trp Ser Asp Ile Ala Ser Glu 
        35                  40                  45              


Phe Tyr Trp Lys Gln Lys Trp Gly Asp Gln Val Phe Ser Glu Asn Leu 
    50                  55                  60                  


Asp Val Arg Lys Gly Pro Ile Ser Ile Glu Trp Phe Lys Gly Gly Ile 
65                  70                  75                  80  


Thr Asn Ile Cys Tyr Asn Cys Leu Asp Lys Asn Val Glu Ala Gly Leu 
                85                  90                  95      


Gly Asp Lys Thr Ala Ile His Trp Glu Gly Asn Glu Leu Gly Val Asp 
            100                 105                 110         


Ala Ser Leu Thr Tyr Ser Glu Leu Leu Gln Arg Val Cys Gln Leu Ala 
        115                 120                 125             


Asn Tyr Leu Lys Asp Asn Gly Val Lys Lys Gly Asp Ala Val Val Ile 
    130                 135                 140                 


Tyr Leu Pro Met Leu Met Glu Leu Pro Ile Ala Met Leu Ala Cys Ala 
145                 150                 155                 160 


Arg Ile Gly Ala Val His Ser Val Val Phe Ala Gly Phe Ser Ala Asp 
                165                 170                 175     


Ser Leu Ala Gln Arg Ile Val Asp Cys Lys Pro Asn Val Ile Leu Thr 
            180                 185                 190         


Cys Asn Ala Val Lys Arg Gly Pro Lys Thr Ile Asn Leu Lys Ala Ile 
        195                 200                 205             


Val Asp Ala Ala Leu Asp Gln Ser Ser Lys Asp Gly Val Ser Val Gly 
    210                 215                 220                 


Ile Cys Leu Thr Tyr Asp Asn Ser Leu Ala Thr Thr Arg Glu Asn Thr 
225                 230                 235                 240 


Lys Trp Gln Asn Gly Arg Asp Val Trp Trp Gln Asp Val Ile Ser Gln 
                245                 250                 255     


Tyr Pro Thr Ser Cys Glu Val Glu Trp Val Asp Ala Glu Asp Pro Leu 
            260                 265                 270         


Phe Leu Leu Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys Gly Val Leu 
        275                 280                 285             


His Thr Thr Gly Gly Tyr Met Ile Tyr Thr Ala Thr Thr Phe Lys Tyr 
    290                 295                 300                 


Ala Phe Asp Tyr Lys Ser Thr Asp Val Tyr Trp Cys Thr Ala Asp Cys 
305                 310                 315                 320 


Gly Trp Ile Gly Gly His Ser Tyr Val Thr Tyr Gly Pro Met Leu Asn 
                325                 330                 335     


Gly Ala Thr Val Val Val Phe Glu Gly Ala Pro Asn Tyr Pro Asp Pro 
            340                 345                 350         


Gly Arg Cys Trp Asp Ile Val Asp Lys Tyr Lys Val Ser Ile Phe Tyr 
        355                 360                 365             


Thr Ala Pro Thr Leu Val Arg Ser Leu Met Arg Asp Asp Asp Lys Phe 
    370                 375                 380                 


Val Thr Arg His Ser Arg Lys Ser Leu Arg Val Leu Gly Ser Ala Gly 
385                 390                 395                 400 


Glu Pro Ile Asn Pro Ser Ala Trp Arg Trp Phe Phe Asn Val Val Gly 
                405                 410                 415     


Asp Ser Arg Cys Pro Ile Ser Asp Thr Trp Gly Gln Thr Glu Thr Gly 
            420                 425                 430         


Gly Phe Met Ile Thr Pro Leu Pro Gly Ala Trp Pro Gln Lys Pro Gly 
        435                 440                 445             


Ser Ala Thr Phe Pro Phe Phe Gly Val Gln Pro Val Ile Val Asp Glu 
    450                 455                 460                 


Lys Gly Asn Glu Ile Glu Gly Glu Cys Ser Gly Tyr Leu Cys Val Lys 
465                 470                 475                 480 


Gly Ser Trp Pro Gly Ala Phe Arg Thr Leu Phe Gly Asp His Glu Arg 
                485                 490                 495     


Tyr Glu Thr Thr Tyr Phe Lys Pro Phe Ala Gly Tyr Tyr Phe Ser Gly 
            500                 505                 510         


Asp Gly Cys Ser Arg Asp Lys Asp Gly Tyr Tyr Trp Leu Thr Gly Arg 
        515                 520                 525             


Val Asp Asp Val Ile Asn Val Ser Gly His Arg Ile Gly Thr Ala Glu 
    530                 535                 540                 


Val Glu Ser Ala Leu Val Leu His Pro Gln Cys Ala Glu Ala Ala Val 
545                 550                 555                 560 


Val Gly Ile Glu His Glu Val Lys Gly Gln Gly Ile Tyr Ala Phe Val 
                565                 570                 575     


Thr Leu Leu Glu Gly Val Pro Tyr Ser Glu Glu Leu Arg Lys Ser Leu 
            580                 585                 590         


Val Leu Met Val Arg Asn Gln Ile Gly Ala Phe Ala Ala Pro Asp Arg 
        595                 600                 605             


Ile His Trp Ala Pro Gly Leu Pro Lys Thr Arg Ser Gly Lys Ile Met 
    610                 615                 620                 


Arg Arg Ile Leu Arg Lys Ile Ala Ser Arg Gln Leu Glu Glu Leu Gly 
625                 630                 635                 640 


Asp Thr Ser Thr Leu Ala Asp Pro Ser Val Val Asp Gln Leu Ile Ala 
                645                 650                 655     


Leu Ala Asp Val 
            660 


<210>  106
<211>  101
<212>  PRT
<213>  Unknown

<220>
<223>  PKC1.0 (polyketide cyclase)

<400>  106

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys 
            100     


<210>  107
<211>  101
<212>  PRT
<213>  Unknown

<220>
<223>  PKC1.1 (polyketide cyclase)

<400>  107

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Phe Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln 
        35                  40                  45              


Lys Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
    50                  55                  60                  


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
65                  70                  75                  80  


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
                85                  90                  95      


Tyr Thr Pro Arg Lys 
            100     


<210>  108
<211>  115
<212>  PRT
<213>  Unknown

<220>
<223>  PKC4.33 (polyketide cyclase)

<400>  108

Met Gly Glu Ala Asn Lys Gly Val Val Lys His Val Ile Ile Leu Lys 
1               5                   10                  15      


Phe Lys Glu Gly Ile Thr Glu Ala Gln Lys Glu Glu Met Phe Lys Thr 
            20                  25                  30          


Tyr Val Asn Leu Val Asn Leu Val Pro Ala Met Lys Ala Val Gln Trp 
        35                  40                  45              


Gly Lys Leu Glu Val Asn Asn Lys Leu Gly Asn Gly Gly Tyr Thr His 
    50                  55                  60                  


Ile Val Glu Ser Thr Phe Glu Ser Val Glu Thr Ile Gln Asp Tyr Ile 
65                  70                  75                  80  


Ile His Pro Ala His Val Gly Phe Gly Asp Val Tyr Arg Ser Phe Trp 
                85                  90                  95      


Glu Lys Leu Leu Ile Phe Asp Tyr Thr Pro Thr Ile Val Leu Pro Asn 
            100                 105                 110         


Ser Ser Tyr 
        115 


<210>  109
<211>  102
<212>  PRT
<213>  Unknown

<220>
<223>  PKC11 (polyketide cyclase)

<400>  109

Met Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr 
1               5                   10                  15      


Glu Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn 
            20                  25                  30          


Ile Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Leu Glu Val Asn 
        35                  40                  45              


Asn Lys Leu Gly Asn Gly Gly Tyr Thr His Ile Val Glu Val Thr Phe 
    50                  55                  60                  


Glu Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val 
65                  70                  75                  80  


Gly Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe 
                85                  90                  95      


Asp Tyr Thr Pro Arg Lys 
            100         


<210>  110
<211>  817
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-PKC1.1-F18-APT73.77, geranyl diphosphate synthase, 
       polyketide cyclase, mutant soluble aromatic prentyltransfeerase 
       fusion protein

<400>  110

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr Glu 
385                 390                 395                 400 


Ala Gln Lys Glu Glu Phe Phe Lys Thr Phe Val Asn Leu Val Asn Ile 
                405                 410                 415     


Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Asp Val Thr Gln Lys 
            420                 425                 430         


Asn Lys Glu Glu Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu Ser 
        435                 440                 445             


Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly Phe 
    450                 455                 460                 


Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp Tyr 
465                 470                 475                 480 


Thr Pro Arg Lys Gly Gly Gly Gly Ser Leu Glu Asp Pro Ala Val Trp 
                485                 490                 495     


Glu Ala Gly Lys Val Val Ala Lys Gly Val Gly Thr Ala Asp Ile Thr 
            500                 505                 510         


Ala Thr Thr Ser Asn Gly Leu Ile Ala Ser Ser Glu Glu Ala Asp Asn 
        515                 520                 525             


Ala Ala Thr Ser Met Asp Glu Val Tyr Ala Ala Val Glu Gln Thr Ser 
    530                 535                 540                 


Arg Leu Leu Asp Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp 
545                 550                 555                 560 


Lys Ala Phe Gly Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met 
                565                 570                 575     


Ala Ala Gly Glu Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu 
            580                 585                 590         


Arg Pro Glu Gly Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe 
        595                 600                 605             


Ile Glu Pro Thr Asp His Pro Val Gly Ser Val Leu Ala Glu Val Gly 
    610                 615                 620                 


Lys Arg Phe Ala Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly 
625                 630                 635                 640 


Gly Phe Lys Lys Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro 
                645                 650                 655     


Leu Ala Gln Phe Ala Glu Val Pro Ser Val Pro Pro Cys Leu Ala Gly 
            660                 665                 670         


His Val Glu Thr Leu Thr Arg Leu Gly Phe Asp Asp Lys Val Ser Ile 
        675                 680                 685             


Ile Gly Val Asn Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala 
    690                 695                 700                 


Ser Ala Val Asp Thr Gly Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly 
705                 710                 715                 720 


Tyr Pro Glu Pro Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe 
                725                 730                 735     


Arg Leu Tyr Pro Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile 
            740                 745                 750         


Cys Phe Ala Val His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His 
        755                 760                 765             


Asp Glu Pro Thr Glu Ala Phe Ala Arg Gln Val Pro His Val Tyr Glu 
    770                 775                 780                 


Gly Gly Arg Glu Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala 
785                 790                 795                 800 


Ser Tyr Tyr Lys Leu Ala Ala Leu Tyr Gln Lys Ala Arg Arg Cys Leu 
                805                 810                 815     


His 
    


<210>  111
<211>  831
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-PKC4.33-F18-APT73.77, geranyl diphosphate synthase, 
       polyketide cyclase, mutant soluble aromatic prenyltransferase 
       fusion protein

<400>  111

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Gly Glu Ala Asn Lys Gly Val Val Lys His Val Ile Ile Leu Lys Phe 
385                 390                 395                 400 


Lys Glu Gly Ile Thr Glu Ala Gln Lys Glu Glu Met Phe Lys Thr Tyr 
                405                 410                 415     


Val Asn Leu Val Asn Leu Val Pro Ala Met Lys Ala Val Gln Trp Gly 
            420                 425                 430         


Lys Leu Glu Val Asn Asn Lys Leu Gly Asn Gly Gly Tyr Thr His Ile 
        435                 440                 445             


Val Glu Ser Thr Phe Glu Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile 
    450                 455                 460                 


His Pro Ala His Val Gly Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu 
465                 470                 475                 480 


Lys Leu Leu Ile Phe Asp Tyr Thr Pro Thr Ile Val Leu Pro Asn Ser 
                485                 490                 495     


Ser Tyr Gly Gly Gly Gly Ser Leu Glu Asp Pro Ala Val Trp Glu Ala 
            500                 505                 510         


Gly Lys Val Val Ala Lys Gly Val Gly Thr Ala Asp Ile Thr Ala Thr 
        515                 520                 525             


Thr Ser Asn Gly Leu Ile Ala Ser Ser Glu Glu Ala Asp Asn Ala Ala 
    530                 535                 540                 


Thr Ser Met Asp Glu Val Tyr Ala Ala Val Glu Gln Thr Ser Arg Leu 
545                 550                 555                 560 


Leu Asp Val Pro Cys Ser Pro Asp Arg Phe Glu Pro Val Trp Lys Ala 
                565                 570                 575     


Phe Gly Asp Gln Leu Pro Asp Ser His Leu Val Phe Ser Met Ala Ala 
            580                 585                 590         


Gly Glu Ala His Arg Gly Glu Leu Asp Phe Asp Phe Ser Leu Arg Pro 
        595                 600                 605             


Glu Gly Ala Asp Pro Tyr Thr Thr Ala Leu Glu His Gly Phe Ile Glu 
    610                 615                 620                 


Pro Thr Asp His Pro Val Gly Ser Val Leu Ala Glu Val Gly Lys Arg 
625                 630                 635                 640 


Phe Ala Ile Ala Ser Tyr Gly Val Glu Tyr Gly Val Val Gly Gly Phe 
                645                 650                 655     


Lys Lys Ser Tyr Ala Phe Phe Pro Leu Asp Asp Phe Pro Pro Leu Ala 
            660                 665                 670         


Gln Phe Ala Glu Val Pro Ser Val Pro Pro Cys Leu Ala Gly His Val 
        675                 680                 685             


Glu Thr Leu Thr Arg Leu Gly Phe Asp Asp Lys Val Ser Ile Ile Gly 
    690                 695                 700                 


Val Asn Tyr Arg Lys Asn Thr Leu Asn Val Tyr Leu Ala Ala Ser Ala 
705                 710                 715                 720 


Val Asp Thr Gly Asp Lys Leu Ala Leu Leu Arg Ala Phe Gly Tyr Pro 
                725                 730                 735     


Glu Pro Asp Ala Arg Val Arg Gln Phe Ile Glu Arg Ser Phe Arg Leu 
            740                 745                 750         


Tyr Pro Thr Phe Asn Trp Asp Ser Ser Ala Ala Glu Arg Ile Cys Phe 
        755                 760                 765             


Ala Val His Thr Gln Gln Pro Gly Glu Leu Pro Ala Pro His Asp Glu 
    770                 775                 780                 


Pro Thr Glu Ala Phe Ala Arg Gln Val Pro His Val Tyr Glu Gly Gly 
785                 790                 795                 800 


Arg Glu Phe Val Ser Gly Val Ala Leu Ala Pro Ser Gly Ala Ser Tyr 
                805                 810                 815     


Tyr Lys Leu Ala Ala Leu Tyr Gln Lys Ala Arg Arg Cys Leu His 
            820                 825                 830     


<210>  112
<211>  744
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-PKC4.33-APT73.77, geranyl diphosphate synthase, polyketide
       cyclase, mutant soluble aromatic prenyltransferase fusion protein

<400>  112

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Met Gly Glu Ala Asn Lys Gly Val 
            340                 345                 350         


Val Lys His Val Ile Ile Leu Lys Phe Lys Glu Gly Ile Thr Glu Ala 
        355                 360                 365             


Gln Lys Glu Glu Met Phe Lys Thr Tyr Val Asn Leu Val Asn Leu Val 
    370                 375                 380                 


Pro Ala Met Lys Ala Val Gln Trp Gly Lys Leu Glu Val Asn Asn Lys 
385                 390                 395                 400 


Leu Gly Asn Gly Gly Tyr Thr His Ile Val Glu Ser Thr Phe Glu Ser 
                405                 410                 415     


Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly Phe 
            420                 425                 430         


Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp Tyr 
        435                 440                 445             


Thr Pro Thr Ile Val Leu Pro Asn Ser Ser Tyr Met Asp Glu Val Tyr 
    450                 455                 460                 


Ala Ala Val Glu Gln Thr Ser Arg Leu Leu Asp Val Pro Cys Ser Pro 
465                 470                 475                 480 


Asp Arg Phe Glu Pro Val Trp Lys Ala Phe Gly Asp Gln Leu Pro Asp 
                485                 490                 495     


Ser His Leu Val Phe Ser Met Ala Ala Gly Glu Ala His Arg Gly Glu 
            500                 505                 510         


Leu Asp Phe Asp Phe Ser Leu Arg Pro Glu Gly Ala Asp Pro Tyr Thr 
        515                 520                 525             


Thr Ala Leu Glu His Gly Phe Ile Glu Pro Thr Asp His Pro Val Gly 
    530                 535                 540                 


Ser Val Leu Ala Glu Val Gly Lys Arg Phe Ala Ile Ala Ser Tyr Gly 
545                 550                 555                 560 


Val Glu Tyr Gly Val Val Gly Gly Phe Lys Lys Ser Tyr Ala Phe Phe 
                565                 570                 575     


Pro Leu Asp Asp Phe Pro Pro Leu Ala Gln Phe Ala Glu Val Pro Ser 
            580                 585                 590         


Val Pro Pro Cys Leu Ala Gly His Val Glu Thr Leu Thr Arg Leu Gly 
        595                 600                 605             


Phe Asp Asp Lys Val Ser Ile Ile Gly Val Asn Tyr Arg Lys Asn Thr 
    610                 615                 620                 


Leu Asn Val Tyr Leu Ala Ala Ser Ala Val Asp Thr Gly Asp Lys Leu 
625                 630                 635                 640 


Ala Leu Leu Arg Ala Phe Gly Tyr Pro Glu Pro Asp Ala Arg Val Arg 
                645                 650                 655     


Gln Phe Ile Glu Arg Ser Phe Arg Leu Tyr Pro Thr Phe Asn Trp Asp 
            660                 665                 670         


Ser Ser Ala Ala Glu Arg Ile Cys Phe Ala Val His Thr Gln Gln Pro 
        675                 680                 685             


Gly Glu Leu Pro Ala Pro His Asp Glu Pro Thr Glu Ala Phe Ala Arg 
    690                 695                 700                 


Gln Val Pro His Val Tyr Glu Gly Gly Arg Glu Phe Val Ser Gly Val 
705                 710                 715                 720 


Ala Leu Ala Pro Ser Gly Ala Ser Tyr Tyr Lys Leu Ala Ala Leu Tyr 
                725                 730                 735     


Gln Lys Ala Arg Arg Cys Leu His 
            740                 


<210>  113
<211>  833
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-PKC11-F11-MPT4, geranyl diphosphate synthase, 
       polyketide cyclase, membrane-bound prenyltransferase fusion 
       protein

<400>  113

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr Glu 
385                 390                 395                 400 


Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn Ile 
                405                 410                 415     


Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Leu Glu Val Asn Asn 
            420                 425                 430         


Lys Leu Gly Asn Gly Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
        435                 440                 445             


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
    450                 455                 460                 


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
465                 470                 475                 480 


Tyr Thr Pro Arg Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala 
                485                 490                 495     


Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn 
        515                 520                 525             


Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu 
    530                 535                 540                 


Gln Arg Pro Tyr Val Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu 
545                 550                 555                 560 


Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu 
                565                 570                 575     


Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe 
            580                 585                 590         


Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile 
        595                 600                 605             


Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr 
    610                 615                 620                 


Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr 
625                 630                 635                 640 


Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly 
                645                 650                 655     


Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln 
            660                 665                 670         


Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu 
        675                 680                 685             


Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe 
    690                 695                 700                 


Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met 
705                 710                 715                 720 


Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp 
                725                 730                 735     


Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn 
            740                 745                 750         


Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser 
        755                 760                 765             


Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met 
    770                 775                 780                 


Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg 
785                 790                 795                 800 


Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe 
                805                 810                 815     


Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe 
            820                 825                 830         


Ile 
    


<210>  114
<211>  833
<212>  PRT
<213>  Artificial

<220>
<223>  GPS1.1-F11-PKC11-F11-MPT4.1, geranyl diphosphate synthase, 
       polyketide cyclase, point mutant membrane-bound, 
       prenyltransferase fusion protein

<400>  114

Met Ser Lys Ala Lys Phe Glu Ser Val Phe Pro Arg Ile Ser Glu Glu 
1               5                   10                  15      


Leu Val Gln Leu Leu Arg Asp Glu Gly Leu Pro Gln Asp Ala Val Gln 
            20                  25                  30          


Trp Phe Ser Asp Ser Leu Gln Tyr Asn Cys Val Gly Gly Lys Leu Asn 
        35                  40                  45              


Arg Gly Leu Ser Val Val Asp Thr Tyr Gln Leu Leu Thr Gly Lys Lys 
    50                  55                  60                  


Glu Leu Asp Asp Glu Glu Tyr Tyr Arg Leu Ala Leu Leu Gly Trp Leu 
65                  70                  75                  80  


Ile Glu Leu Leu Gln Ala Phe Trp Leu Val Ser Asp Asp Ile Met Asp 
                85                  90                  95      


Glu Ser Lys Thr Arg Arg Gly Gln Pro Cys Trp Tyr Leu Lys Pro Lys 
            100                 105                 110         


Val Gly Met Ile Ala Ile Trp Asp Ala Phe Met Leu Glu Ser Gly Ile 
        115                 120                 125             


Tyr Ile Leu Leu Lys Lys His Phe Arg Gln Glu Lys Tyr Tyr Ile Asp 
    130                 135                 140                 


Leu Val Glu Leu Phe His Asp Ile Ser Phe Lys Thr Glu Leu Gly Gln 
145                 150                 155                 160 


Leu Val Asp Leu Leu Thr Ala Pro Glu Asp Glu Val Asp Leu Asn Arg 
                165                 170                 175     


Phe Ser Leu Asp Lys His Ser Phe Ile Val Arg Tyr Lys Thr Ala Tyr 
            180                 185                 190         


Tyr Ser Phe Tyr Leu Pro Val Val Leu Ala Met Tyr Val Ala Gly Ile 
        195                 200                 205             


Thr Asn Pro Lys Asp Leu Gln Gln Ala Met Asp Val Leu Ile Pro Leu 
    210                 215                 220                 


Gly Glu Tyr Phe Gln Val Gln Asp Asp Tyr Leu Asp Asn Phe Gly Asp 
225                 230                 235                 240 


Pro Glu Phe Ile Gly Lys Ile Gly Thr Asp Ile Gln Asp Asn Lys Cys 
                245                 250                 255     


Ser Trp Leu Val Asn Lys Ala Leu Gln Lys Ala Thr Pro Glu Gln Arg 
            260                 265                 270         


Gln Ile Leu Glu Asp Asn Tyr Gly Val Lys Asp Lys Ser Lys Glu Leu 
        275                 280                 285             


Val Ile Lys Lys Leu Tyr Asp Asp Met Lys Ile Glu Gln Asp Tyr Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Glu Val Val Gly Asp Ile Lys Lys Lys Ile Glu Gln 
305                 310                 315                 320 


Val Asp Glu Ser Arg Gly Phe Lys Lys Glu Val Leu Asn Ala Phe Leu 
                325                 330                 335     


Ala Lys Ile Tyr Lys Arg Gln Lys Gly Gly Ala Glu Ala Ala Ala Lys 
            340                 345                 350         


Glu Ala Ala Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    370                 375                 380                 


Ala Val Lys His Leu Ile Val Leu Lys Phe Lys Asp Glu Ile Thr Glu 
385                 390                 395                 400 


Ala Gln Lys Glu Glu Phe Phe Lys Thr Tyr Val Asn Leu Val Asn Ile 
                405                 410                 415     


Ile Pro Ala Met Lys Asp Val Tyr Trp Gly Lys Leu Glu Val Asn Asn 
            420                 425                 430         


Lys Leu Gly Asn Gly Gly Tyr Thr His Ile Val Glu Val Thr Phe Glu 
        435                 440                 445             


Ser Val Glu Thr Ile Gln Asp Tyr Ile Ile His Pro Ala His Val Gly 
    450                 455                 460                 


Phe Gly Asp Val Tyr Arg Ser Phe Trp Glu Lys Leu Leu Ile Phe Asp 
465                 470                 475                 480 


Tyr Thr Pro Arg Lys Gly Gly Ala Glu Ala Ala Ala Lys Glu Ala Ala 
                485                 490                 495     


Ala Lys Ala Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Asp Asn 
        515                 520                 525             


Ser Ile Ala Thr Lys Ile Leu Asn Phe Gly His Thr Cys Trp Lys Leu 
    530                 535                 540                 


Gln Arg Pro Tyr Ala Val Lys Gly Met Ile Ser Ile Ala Cys Gly Leu 
545                 550                 555                 560 


Phe Gly Arg Glu Leu Phe Asn Asn Arg His Leu Phe Ser Trp Gly Leu 
                565                 570                 575     


Met Trp Lys Ala Phe Phe Ala Leu Val Pro Ile Leu Ser Phe Asn Phe 
            580                 585                 590         


Phe Ala Ala Ile Met Asn Gln Ile Tyr Asp Val Asp Ile Asp Arg Ile 
        595                 600                 605             


Asn Lys Pro Asp Leu Pro Leu Val Ser Gly Glu Met Ser Ile Glu Thr 
    610                 615                 620                 


Ala Trp Ile Leu Ser Ile Ile Val Ala Leu Thr Gly Leu Ile Val Thr 
625                 630                 635                 640 


Ile Lys Leu Lys Ser Ala Pro Leu Phe Val Phe Ile Tyr Ile Phe Gly 
                645                 650                 655     


Ile Phe Ala Gly Phe Ala Tyr Ser Val Pro Pro Ile Arg Trp Lys Gln 
            660                 665                 670         


Tyr Pro Phe Thr Asn Phe Leu Ile Thr Ile Ser Ser His Val Gly Leu 
        675                 680                 685             


Ala Phe Thr Ser Tyr Ser Ala Thr Thr Ser Ala Leu Gly Leu Pro Phe 
    690                 695                 700                 


Val Trp Arg Pro Ala Phe Ser Phe Ile Ile Ala Phe Met Thr Val Met 
705                 710                 715                 720 


Gly Met Thr Ile Ala Phe Ala Lys Asp Ile Ser Asp Ile Glu Gly Asp 
                725                 730                 735     


Ala Lys Tyr Gly Val Ser Thr Val Ala Thr Lys Leu Gly Ala Arg Asn 
            740                 745                 750         


Met Thr Phe Val Val Ser Gly Val Leu Leu Leu Asn Tyr Leu Val Ser 
        755                 760                 765             


Ile Ser Ile Gly Ile Ile Trp Pro Gln Val Phe Lys Ser Asn Ile Met 
    770                 775                 780                 


Ile Leu Ser His Ala Ile Leu Ala Phe Cys Leu Ile Phe Gln Thr Arg 
785                 790                 795                 800 


Glu Leu Ala Leu Ala Asn Tyr Ala Ser Ala Pro Ser Arg Gln Phe Phe 
                805                 810                 815     


Glu Phe Ile Trp Leu Leu Tyr Tyr Ala Glu Tyr Phe Val Tyr Val Phe 
            820                 825                 830         


Ile 
    


