                         SEQUENCE LISTING

<110>  BioLegend, Inc
 
<120>  Anti-CCR8 antibodies, antigen binding fragments thereof, and 
       agents and compositions and methods for making and using the same

<130>  BLD017WO1

<150>  63/187,839
<151>  2021-05-12

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  1

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


His Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Lys Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Arg Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Asp Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is S, G, Y, N, D, T or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Y, A or N

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is H, A or V

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is I, V or M

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is S, Y or N

<400>  2

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  3
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  3

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


His Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Lys Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Asp Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  4
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  4

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


His Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Arg Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Asp Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  5
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  5

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


His Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Ser Thr Thr Tyr Asn Ser Leu Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Ile Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Thr Val Val Lys Gly Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  6
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is V, R or E

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is I or L

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is W, R or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is G, T, P or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D, G or K

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is G, P or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is S, K, R, N or D

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is N, T, K or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Y, T or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is A, Y or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is K, T or Y

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is T, Y or N

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Y or E

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is N, A, I, K or V

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is S, D or F

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is A, L, S or K

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is L, V or G

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is S, G or D

<400>  6

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Lys Xaa 
            


<210>  7
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  7

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ala 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Asn Leu Lys Ser Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Asn Ile Met Gly Ile Thr Arg Gly Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  8

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Ala 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Pro Lys Asn Tyr Ala Thr Tyr Tyr Ile Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Asn Thr Met Gly Leu Thr Arg Ala Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120         


<210>  9
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Asp Thr Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Gly Gly Phe Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  10
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  10

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Lys Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Lys Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Ser Glu Met Gly Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  11
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Leu Arg Ser Lys Ser Asn Phe Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Arg Glu Leu Gly Pro Ser Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Leu Arg Ser Lys Ser Asn Phe Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Arg Glu Leu Gly Pro Ser Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  13
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  13

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Thr Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Arg Ala Thr Val Thr Thr Gly Arg Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  14
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Val Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Arg Glu Leu Gly Pro Tyr Ser Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  15
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is G, M or D

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is G, S or R

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is T, I, L, E, A, or D

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is V, T, G, L or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is V, R, G, M, L or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is K, G, A, F, P, T or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is S, G, Y, F, T or P

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is G, Y or D

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is F, V, Y, A, R, or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is A, D or M

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Y, M or D

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is D or Y

<400>  15

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Tyr 
1               5                   10                  


<210>  16
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Arg Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Gly Arg Gly Asn Leu Gly Lys Glu Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 125 


<210>  17
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Arg Leu Gln Val 
65                  70                  75                  80  


Glu Asp Ile Gly Ile Tyr Tyr Cys Leu Gln Ala Tyr Ser Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  18
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Q, K or R

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is A or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Q, E or K

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D, N or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is I or L

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is G, N, Y or L

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is N, R, S or H

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is W, R, Y or S

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is L or N

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is S, N, A or G

<400>  18

Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  G, N or R

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  T, A or M

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  T, N, K or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  N, S or T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  L or V

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  A, Q or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  D, T, E or S

<400>  19

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  20
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Gln Phe Ser Leu Lys Ile Ser Arg Leu Gln Val 
65                  70                  75                  80  


Glu Asp Ile Gly Ile Tyr Tyr Cys Leu Gln Ala Tyr Ile Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ser Lys 
            100                 105         


<210>  21
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Arg 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Arg Leu Gln Val 
65                  70                  75                  80  


Glu Asp Ile Gly Ile Tyr Tyr Cys Leu Gln Ala Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  22
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L, Q or M

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is A or H

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Y, N or L

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is S, D or E

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is V, W, S or Y

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is L, W, F or Y

<400>  22

Xaa Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  23
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn Ile Asn Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Gln Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Leu Gln His Asn Ser Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  24
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ala Ser Gln Asn Ile Asn Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Leu Gln His Asn Ser Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  25
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


His Asn Ala Lys Thr Val Ile Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Asp Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  26

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  27
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  27

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  28
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  28

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  29

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Ala Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  30
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  30

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  31
<211>  355
<212>  PRT
<213>  artificial sequence

<220>
<223>  full length CCR8

<400>  31

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  32
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  32

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  33
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH1

<400>  33

Ser Tyr His Ile Ser 
1               5   


<210>  34
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH2

<400>  34

Val Ile Trp Gly Asp Gly Ser Lys Thr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  35
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH3

<400>  35

Gly Gly Asp Ser Gly Phe Ala Tyr 
1               5               


<210>  36
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL1

<400>  36

Gln Ala Ser Gln Asp Ile Gly Asn Trp Leu Ser 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL2

<400>  37

Gly Thr Thr Asn Leu Ala Asp 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL3

<400>  38

Leu Gln Ala Tyr Ser Val Pro Leu Thr 
1               5                   


<210>  39
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH1

<400>  39

Gly Tyr His Val Ser 
1               5   


<210>  40
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH2

<400>  40

Val Ile Trp Gly Asp Gly Lys Thr Thr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  41
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH3

<400>  41

Gly Gly Thr Val Val Lys Gly Gly Phe Ala Tyr 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL1

<400>  42

Gln Ala Ser Gln Asp Ile Gly Asn Arg Leu Ser 
1               5                   10      


<210>  43
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL2

<400>  43

Gly Ala Thr Ser Leu Ala Asp 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL3

<400>  44

Leu Gln Ala Tyr Ile Val Pro Leu Thr 
1               5                   


<210>  45
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH1

<400>  45

Ser Tyr His Val Ser 
1               5   


<210>  46
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH2

<400>  46

Val Ile Trp Gly Asp Gly Arg Thr Thr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  47
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH3

<400>  47

Met Gly Ile Thr Arg Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL1

<400>  48

Lys Ala Ser Gln Asn Ile Asn Arg Tyr Leu Asn 
1               5                   10      


<210>  49
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL2

<400>  49

Asn Ala Asn Asn Leu Gln Thr 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL3

<400>  50

Leu Gln His Asn Ser Trp Pro Trp Thr 
1               5                   


<210>  51
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH1

<400>  51

Tyr Ala Ala Met Tyr 
1               5   


<210>  52
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH2

<400>  52

Val Ile Trp Thr Gly Gly Ser Thr Thr Tyr Asn Ser Leu Leu Lys Ser 
1               5                   10                  15      


<210>  53
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH3

<400>  53

Met Gly Leu Thr Arg Ala Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL1

<400>  54

Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  55
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL2

<400>  55

Asn Ala Asn Ser Leu Gln Thr 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL3

<400>  56

Gln His His Tyr Asp Ser Pro Trp Thr 
1               5                   


<210>  57
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH1

<400>  57

Asn Ala Ala Met Tyr 
1               5   


<210>  58
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH2

<400>  58

Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  59
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH3

<400>  59

Gly Gly Leu Gly Gly Phe Phe Asp Val 
1               5                   


<210>  60
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL1

<400>  60

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  61
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL2

<400>  61

Asn Ala Lys Thr Val Ile Glu 
1               5           


<210>  62
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL3

<400>  62

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  63
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH1

<400>  63

Asp Tyr Val Ile Ser 
1               5   


<210>  64
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH2

<400>  64

Arg Ile Arg Thr Lys Pro Lys Asn Tyr Ala Thr Tyr Tyr Ile Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  65
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH3

<400>  65

Gly Ser Glu Met Gly Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  66
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL2

<400>  66

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  67
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRL3

<400>  67

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  68
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH1

<400>  68

Thr Asn Ala Met Asn 
1               5   


<210>  69
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH2

<400>  69

Glu Ile Tyr Pro Gly Ser Asp Thr Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH3

<400>  70

Gly Arg Glu Leu Gly Pro Ser Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  71
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH1

<400>  71

Thr Tyr Ala Met Asn 
1               5   


<210>  72
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH2

<400>  72

Arg Ile Arg Ser Lys Ser Asn Lys Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  73
<211>  13
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH3

<400>  73

Asp Arg Ala Thr Val Thr Thr Gly Arg Ala Met Asp Tyr 
1               5                   10              


<210>  74
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH1

<400>  74

Ala Tyr Ala Met Asn 
1               5   


<210>  75
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH2

<400>  75

Arg Leu Arg Ser Lys Ser Asn Phe Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  76
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH3

<400>  76

Gly Arg Glu Leu Gly Pro Tyr Ser Ala Met Asp Tyr 
1               5                   10          


<210>  77
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH2

<400>  77

Arg Ile Arg Thr Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  78
<211>  19
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH2

<400>  78

Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Val Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  79
<211>  14
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH3

<400>  79

Gly Gly Arg Gly Asn Leu Gly Lys Glu Tyr Tyr Phe Asp Tyr 
1               5                   10                  


<210>  80
<211>  217
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Wild-type CH2-CH3 portion of Fc

<400>  80

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  81
<211>  465
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  heavy chain variable domain

<400>  81
atggctgtcc tggtgctgtt gctctgcctg ctgacatttc caagctgtgt cctgtcccag       60

gtccagctga aggagtcagg acctggcctg gtgaagccct cagagaccct gtctctcacc      120

tgcactgtct ctgggttctc attaaccagc tatcatataa gctgggttcg acagcctcca      180

ggaaagggtc tggagtggat gggagtaata tggggtgatg gaagtaaaac atataattca      240

gctctcaaat cccgactgag catcagcagg gacacctcca agagccaagt tttcttaaaa      300

atgaggagtc tgaaaactga agacacagcc acttactact gtgccagagg aggggattcg      360

ggctttgctt actggggcca aggcactctg gtcactgtct cttcagctga aacaacagcc      420

ccatctgtct atccactggc tcctggaact gctctcaaaa gtaac                      465


<210>  82
<211>  405
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  82
atggctgtcc tggtgctgtt gctctgcctg ctgacatttc caagctgtgt cctgtcccag       60

gtccagctga aggagtcagg acctggcctg gtgaagccct cagagaccct gtctctcacc      120

tgcactgtct ctgggttctc attaaccagc tatcatataa gctgggttcg acagcctcca      180

ggaaagggtc tggagtggat gggagtaata tggggtgatg gaagtaaaac atataattca      240

gctctcaaat cccgactgag catcagcagg gacacctcca agagccaagt tttcttaaaa      300

atgaggagtc tgaaaactga agacacagcc acttactact gtgccagagg aggggattcg      360

ggctttgctt actggggcca aggcactctg gtcactgtct cttca                      405


<210>  83
<211>  405
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  83
atggctgtcc tggtgctgtt gctctgcctg ctgacatttc caagctgtgt cctgtcccag       60

gtgcagctga aggagtcagg acctggcctg gtgaagccct cagagaccct gtctctcacc      120

tgcactgtct ctgggttctc attaaccagc tatcatataa gctgggttcg acagcctcca      180

ggaaagggtc tggagtggat gggagtaata tggggtgatg gaaagacaac atataattca      240

gctctcaaat cccgactgag catcagcagg gacacctcca agagccaagt tttcttaaaa      300

atgaacagtc tgaaaactga agacacagcc acttactact gtgccagagg aggggattcg      360

ggctttgctt actggggcca aggcactctg gtcactgtct cttca                      405


<210>  84
<211>  405
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  84
atggctgtcc tggtgctgtt gctctgcctg ctgacatttc caagctgtgt cctgtcccag       60

gtgcagctga aggagtcagg acctggcttg gtgaagccct cagagaccct gtctctcacc      120

tgcactgtct ctgggttctc attaaccggc tatcatgtaa gctgggttcg acagcctcca      180

ggaaagggtc tggagtggat gggagtaata tggggtgatg gaaggacaac atataattca      240

gctctcaaat cccgactgag catcagtagg gacacctcca agagccaagt tttcttaaaa      300

atgagcagtc tgaaaactga agacacagcc acttactact gtgccagagg aggggattcg      360

ggctttgctt actggggcca aggcactctg gtcactgtct cttca                      405


<210>  85
<211>  414
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  85
atggctgccc tggtgctgtt gctctgcctg ctgacatttc caagctgtgt cctgtcccag       60

gtgcagctga aggagtcagg acctggtctg gtgcagccct cacagacttt gtctctcacc      120

tgcactgtct ctggattctc actaaccagc tatcatgtaa gctgggttcg ccagcctcca      180

ggaaaaggtc tggagtggat gggagtaata tggactggtg gaagcacaac atataattca      240

cttctcaaat cccgactgag catcagcagg gacatctcca agagccaagt tttcttaaaa      300

atgaacagtc tgcaaactga agacacagcc acttactact gtgccagagg aggtacagtg      360

gtgaaggggg ggtttgctta ctggggccaa ggcactctgg tcactgtctc ttca            414


<210>  86
<211>  414
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  86
atggctgccc tggtgctgtt gctctgcctg ctgacatttc caagctgtgt cctgtcccag       60

gtgcagctga aggagtcagg acctggtctg gtgcagccct cacagacttt gtctctcacc      120

tgcactgtct ctggattctc actaaccagc tatcatgtaa gctgggttcg ccagcctcca      180

ggaaaaggtc tggagtggat gggagtaata tggactggtg gaagcacaac atataattca      240

cttctcaaat cccgactgag catcagcagg gacatctcca agagccaagt tttcttaaaa      300

atgaacagtc tgcaaactga agacacagcc acttactact gtgccagagg aggtacagtg      360

gtgaaggggg ggtttgctta ctggggccaa ggcactctgg tcactgtctc ttca            414


<210>  87
<211>  420
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  87
atgttggtgc tgcagtgggt tttggtgact gctctttttc aaggtgtgca ttgtgcggtg       60

cagcttgttg agtctggtgg aggattggtg cagcctaagg agtcattgaa aatctcatgt      120

gcagcctctg gattcacctt cagttatgct gccatgtact gggtccgcca gactccagga      180

aagggtctgg aatgggttgc tcgcataaga actaaaccta ataattatgc aacatattat      240

gctgattcag tgaaaggcag attcaccatc tccagagatg attcaaaaag catggtctac      300

ctacaaatgg ataacttgaa aagtgaggac acagccatgt attactgtaa tattatgggt      360

ataactaggg gctactactt tgattactgg ggccaaggag tcatggtcac agtctcctca      420


<210>  88
<211>  420
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavyy chain variable domain

<400>  88
atgttggtgc tgcagtgggt tttggtgact gctctttttc aaggtgtgca ttgtgcggtg       60

cagcttgttg agtctggtgg aggattggtg cagcctaagg agtcattgaa aatctcatgt      120

gcagcctctg gattcatctt cagtaatgct gccatgtact gggtccgcca ggctccagga      180

aagggtctgc aatgggttgc tcgcataaga actaaaccta agaattatgc aacatattat      240

attgattcag tgaaaggcag attcaccatc tccagagatg attcaaaaag catggtctac      300

ctacaaatgg ataacttgaa aactgaggac acagccatgt attactgtaa tactatgggt      360

ctaactaggg cctactactt tgattactgg ggccaaggag tcatggtcac agtctcctca      420


<210>  89
<211>  408
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  89
atggaatgga ggatctttct cttcatcctg tcaggaactg caggtgtcca ctcccaggtt       60

cagctgcagc agtctggacc tgagctggtg aagcctgggg cttcagtgaa gatgtcctgc      120

aaggcttctg gatacacatt cactgactat gttataagct gggtgaagca gaggactgga      180

cagggccttg agtggattgg agagatttat cctggaagtg atactactta ctacaatgag      240

aagttcaagg gcaaggccac actgactgca gacaaatcct ccaacacagc ctacatgcag      300

ctcagcagcc tgacatctga ggactctgcg gtctatttct gtgcaagagg gggtctagga      360

gggttcttcg atgtctgggg cgcagggacc acggtcaccg tctcctca                   408


<210>  90
<211>  426
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  90
atgctgttgg ggctgaagtg ggttttcttt gttgtttttt atcaaggtgt gcattgtgag       60

gtgcagcttg ttgagactgg tggaggattg gtgcagccta aagggtcatt gaaactctca      120

tgtgcagtct ctggattcac cttcaaaacc aatgccatga actgggtccg ccaggctcca      180

ggaaagggtt tggaatgggt tgctcgcata agaagtaaaa gtaataaata tgcaacatat      240

tatgccgatt cagtgaaaga caggttcacc atctccagag atgattcaca aagcatgctc      300

tatctgcaaa tgaacaactt gaaaactgag gacacagcca tgtattactg tgtgagagga      360

tcagagatgg ggtattacta tgctatggac tactggggtc aaggaacctc agtcaccgtc      420

tcctca                                                                 426


<210>  91
<211>  426
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  91
atgctgttgg ggctgaagtg ggttttcttt gttgtttttt atcaaggtgt gcattgtgag       60

gtgcagcttg ttgagtctgg tggaggattg gtgcagccta aagggtcatt gaaactctca      120

tgtgcagcct ctggattcgc cttcaatacc tacgccatga actgggtccg ccaggctcca      180

ggaaagggtt tggaatggat tgctcgctta agaagtaaaa gtaattttta tgcaacatat      240

tatgccgatt cagtgaaaga caggttcacc atctccagag atgattcaca aagcatgctc      300

tatctgcaaa tgaacaactt gaaaactgag gacacagccg tgtattactg tgtgagaggg      360

agggaactgg gaccctccta tgctatggac tactggggtc aaggaacctc agtcaccgtc      420

tcctca                                                                 426


<210>  92
<211>  426
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  92
atgctgttgg ggctgaagtg ggttttcttt gttgtttttt atcaaggtgt gcattgtgag       60

gtgcagcttg ttgagtctgg tggaggattg gtgcagccta aagggtcatt gaaactctca      120

tgtgcagcct ctggattcgc cttcaatacc tacgccatga actgggtccg ccaggctcca      180

ggaaagggtt tggaatggat tgctcgctta agaagtaaaa gtaattttta tgcaacatat      240

tatgccgatt cagtgaaaga caggttcacc atctccagag atgattcaca aagcatgctc      300

tatctgcaaa tgaacaactt gaaaactgag gacacagccg tgtattactg tgtgagaggg      360

agggaactgg gaccctccta tgctatggac tactggggtc aaggaacctc agtcaccgtc      420

tcctca                                                                 426


<210>  93
<211>  429
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  93
atgctgttgg ggctgaagtg ggttttcttt gttgtttttt atcaaggtgt gcattgtgag       60

gtgcagcttg ttgagactgg tggaggattg gtgcagccta aagggtcatt gaaactctca      120

tgtgcagcct ctggattcac cttcaatgcc tatgccatga actgggtccg ccaggctcca      180

ggaaagggtt tggaatgggt tgctcgcata agaactaaaa gtaataatta tgcaacatat      240

tatgccgatt cagtgaaaga caggttcacc atctccagag atgattcaca aaccatgctc      300

tatctgcaaa tgaacaactt gaaaactgag gacacagcca tgtattactg tgtgagagat      360

agggctactg tgactacggg gagggctatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctca                                                              429


<210>  94
<211>  426
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  94
atgctgttgg ggctgaagtg ggttttcttt gttgtttttt atcaaggtgt gcattgtgag       60

gtgcagcttg ttgagtctgg tggaggattg gtgcagccta aagggtcatt gaaactctca      120

tgtgcagcct ctggattcac cttcaatacc tacgccatga actgggtccg ccaggctcca      180

ggaaagggtt tggaatgggt tgctcgcata agaagtaaaa gtaataatta tgcaacatat      240

tatgtcgatt cagtgaaaga caggttcacc atctccagag atgattcaca aagcatgctc      300

tatctgcaaa taaacaactt aaaaactgag gacacagcca tgtattactg tgtgagaggg      360

agggaactgg gaccctactc tgctatggac tattggggtc aaggaacctc agtcaccgtc      420

tcctca                                                                 426


<210>  95
<211>  426
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  95
atgctgttgg ggctgaagtg ggttttcttt gttgtttttt atcaaggtgt gcattgtgag       60

gtgcagcttg ttgagtctgg tggaggattg gtgcagccta aagggtcatt gaaactctca      120

tgtgcagcct ctggattcac cttcaatacc tacgccatga actgggtccg ccaggctcca      180

ggaaagggtt tggaatgggt tgctcgcata agaagtaaaa gtaataatta tgcaacatat      240

tatgtcgatt cagtgaaaga caggttcacc atctccagag atgattcaca aagcatgctc      300

tatctgcaaa taaacaactt aaaaactgag gacacagcca tgtattactg tgtgagaggg      360

agggaactgg gaccctactc tgctatggac tattggggtc aaggaacctc agtcaccgtc      420

tcctca                                                                 426


<210>  96
<211>  432
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain variable domain

<400>  96
atgctgttgg ggctgaagtg ggttttcttt gttgtttttt atcaaggtgt gcattgtgag       60

gtgcagcttg ttgagtctgg tggaggattg gtgcagccta aagggtcatt gaaactctca      120

tgtgcagcct ctggattcac cttcaatacc tacgccatga actgggtccg ccaggctcca      180

ggaaagggtt tggaatgggt tgctcgcata agaactaaaa gtaataatta tgcaacatat      240

tatgccgatt cagtgaaaga caggttcacc atctccagag atgattcaaa aagaagggtc      300

tatctgcaaa tgaacaacct gaaaactgag gacacagcca tgtattactg tgtgaggggc      360

ggccggggta acctcgggaa ggagtactac tttgactact ggggccaagg caccactctc      420

acagtctcct ca                                                          432


<210>  97
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  97
atgaacgtgc ccactcaact ccttgggttg ctgatactct ggcttacagg tggtaaatgt       60

gacatccaga tgacacagtc tcctgcctcc ctgtctgcat ctctggaaga aattgtcacc      120

atcacatgcc aggcaagcca ggacattggt aattggttat catggtatca gcagaaacca      180

gggaaatctc ctcagctcct gatctatggt acaaccaact tggcagatgg ggtcccatca      240

aggttcagcg gcagtagatc tggcacacaa tattctctta agatcagcag actacaggtt      300

gaagatattg gaatctatta ctgtctacag gcttatagtg ttccgctcac gttcggttct      360

gggaccaagc tggagatcaa a                                                381


<210>  98
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  98
atgaacgtgc ccactcaact ccttgggttg ctgatactct ggcttacagg tggtaaatgt       60

gacatccaga tgacacagtc tcctgcctcc ctgtctgcat ctctggaaga aattgtcacc      120

atcacatgcc aggcaagcca ggacattggt aattggttat catggtatca gcagaaacca      180

gggaaatctc ctcagctcct gatctatggt acaaccaact tggcagatgg ggtcccatca      240

aggttcagcg gcagtagatc tggcacacaa tattctctta agatcagcag actacaggtt      300

gaagatattg gaatctatta ctgtctacag gcttatagtg ttccgctcac gttcggttct      360

gggaccaagc tggagatcaa a                                                381


<210>  99
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  99
atgaacgtgc ccactcaact ccttgggttg ctgatactct ggcttacagg tggtaaatgt       60

gacatccaga tgacacagtc tcctgcctcc ctgtctgcat ctctggaaga aattgtcacc      120

atcacatgcc aggcaagcca ggacattggt aattggttat catggtatca gcagaaacca      180

gggaaatctc ctcagctcct gatctatggt acaaccaact tggcagatgg ggtcccatca      240

aggttcagcg gcagtagatc tggcacacag tattctctta agatcagcag actacaggtt      300

gaagatattg gaatctatta ctgtctacag gcttatagtg ttccgctcac gttcggttct      360

gggaccaagc tggagatcaa a                                                381


<210>  100
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  100
atgaacgtgc ccactcaact ccttgggttg ctgatactct ggcttacagg tggtaaatgt       60

gacatccaga tgacacagtc tcctgcctcc ctgtctgcat ctctggaaga aattgtcacc      120

atcacatgcc aggcaagcca ggacattggt aattggttat catggtatca gcagaaacca      180

gggaaatctc ctcagctcct gatctatggt gcaaccagct tggcagatgg ggtcccatca      240

aggttcagcg gcagtagatc tggcacgcag ttttctctta agatcagcag actacaggtt      300

gaagatattg gaatctatta ctgtctacag gcttatattg ttccgctcac gttcggttct      360

gggaccaagc tggagagcaa a                                                381


<210>  101
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  101
atgaacgtgc ccactcaact ccttgggttg ctgatactct ggcttacagg tggtaaatgt       60

gacatccaga tgacacagtc tcctgcctcc ctgtctgcat ctctggagga aattgtcacc      120

atcacatgcc aggcaagcca ggacattggt aataggttat catggtatca acagaaacca      180

gggaaatctc ctcagctcct gatctatggt gcaaccagct tggcagatgg ggtcccatca      240

aggttcagcg gcagtagatc tggcacacag tattctctta agatcagcag actacaggtt      300

gaagatattg gaatctatta ctgtctacag gcttatagta ctccgctcac gttcggttct      360

gggaccaagc tggagatcaa a                                                381


<210>  102
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  102
atgaacgtgc ccactcaact ccttgggttg ctgatactct ggcttacagg tggtaaatgt       60

gacatccaga tgacacagtc tcctgcctcc ctgtctgcat ctctggagga aattgtcacc      120

atcacatgcc aggcaagcca ggacattggt aataggttat catggtatca acagaaacca      180

gggaaatctc ctcagctcct gatctatggt gcaaccagct tggcagatgg ggtcccatca      240

aggttcagcg gcagtagatc tggcacacag tattctctta agatcagcag actacaggtt      300

gaagatattg gaatctatta ctgtctacag gcttatagta ctccgctcac gttcggttct      360

gggaccaagc tggagatcaa a                                                381


<210>  103
<211>  378
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  103
atggctgcag ttcaactctt agggctgctg ctgctttggg tcccagccat gagatgtgac       60

atccagatga cccagtctcc ttcattcctg tctgcatctg tgggagacag agtcactatc      120

aactgcaaag caagtcagaa tattaacagg tacttaaact ggtaccagca acaacttgga      180

gaagctccca aactcctgat atataatgca aacaatttgc aaacgggcat cccatcaagg      240

ttcagtggca gtagatctgg tactgatttc acactcacca tcagcagcct gcagcctgaa      300

gatgttgcca catatttctg cttgcagcat aatagttggc cgtggacgtt cggtggaggc      360

accaagctgg aattgaaa                                                    378


<210>  104
<211>  378
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  104
atggctgcag ttcaactctt agggctgctg ctgctttggg tcccagccat gagatgtgac       60

atccagatga cccagtctcc ttcattcctg tctgcatctg tgggagacag agtcactatc      120

aactgcaaag caagtcagaa tattaacagg tacttaaact ggtaccagca aaagcttgga      180

gaagctccca aactcctgat atataatgca aacagtttgc aaacgggcat cccatcaagg      240

ttcagtggca gtggatctgg tactgatttc acactcacca tcagaagcct acagcctgaa      300

gatgttgcca catatttctg cttgcagcat aatagttggc cgtggacgtt cggtggaggc      360

accaagctgg aattgaaa                                                    378


<210>  105
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  105
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacagg tgccagatgt       60

gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc      120

atcacatgtc gagcaagtga aaatatttac agttatttag catggtatca gcagaaacag      180

ggaaaatctc ctcagctcct ggtccataat gcaaagaccg taatagaagg tgtgccatca      240

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      300

gaagattttg ggagttatta ctgtcaacat cattatgata gtccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  106
<211>  396
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  106
atgaggtgcc tagctgagtt cctggggctg cttgtgctct ggatccctgg agccattggg       60

gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc      120

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      180

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      300

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcct      360

ttcacgttcg gaggggggac caagctggaa ataaaa                                396


<210>  107
<211>  396
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  107
atgaggtgcc tagctgagtt cctggggctg cttgtgctct ggatccctgg agccattggg       60

gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc      120

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      180

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      300

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatccg      360

tacacgttcg gaggggggac caagctggaa ataaaa                                396


<210>  108
<211>  396
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  108
atgaggtgcc tagctgagtt cctggggctg cttgtgctct ggatccctgg agccattggg       60

gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc      120

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      180

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      300

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatccg      360

tacacgttcg gaggggggac caagctggaa ataaaa                                396


<210>  109
<211>  396
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  109
atgaggtgcc tagctgagtt cctggggctg cttgtgctct ggatccctgg agccattggg       60

gatattgtga tgactcaggc tgcaccctct ctacctgtca ctcctggaga gtcagtatcc      120

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      180

ttcctgcaga gggcaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      300

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcca      360

ttcacgttcg gctcggggac aaagttggaa ataaaa                                396


<210>  110
<211>  396
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  110
atgaggtgcc tagctgagtt cctggggctg cttgtgctct ggatccctgg agccattggg       60

gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc      120

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      180

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      300

agtagagtgg aggctgagga tgtgggtctt tattactgta tgcaacatct agaatatccg      360

ttcacgttcg gaggggggac caagctggaa ataaaa                                396


<210>  111
<211>  396
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  111
atgaggtgcc tagctgagtt cctggggctg cttgtgctct ggatccctgg agccattggg       60

gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc      120

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      180

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      300

agtagagtgg aggctgagga tgtgggtctt tattactgta tgcaacatct agaatatccg      360

ttcacgttcg gaggggggac caagctggaa ataaaa                                396


<210>  112
<211>  396
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain variable domain

<400>  112
atgaggtgcc tagctgagtt cctggggctg cttgtgctct ggatccctgg agccattggg       60

gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc      120

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      180

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      300

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcct      360

ttcacgttcg gaggggggac caagctggaa ataaaa                                396


