                         SEQUENCE LISTING

<110>  MAMMOTH BIOSCIENCES, INC.
 
<120>  EFFECTOR PROTEINS AND METHODS OF USE

<130>  203477-709601/PCT

<150>  63/186,700
<151>  2021-05-10

<150>  63/220,137
<151>  2021-07-09

<150>  63/220,286
<151>  2021-07-09

<150>  63/290,600
<151>  2021-12-16

<150>  63/316,358
<151>  2022-03-03

<160>  943   

<170>  PatentIn version 3.5

<210>  1
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.298706

<400>  1

Met Ala Lys Lys Gly Thr Asn Arg Lys Lys Met Ile Val Lys Val Met 
1               5                   10                  15      


Lys Tyr Glu Leu Lys Tyr Glu Ser Gly Cys Ala Asp Phe Asn Glu Met 
            20                  25                  30          


Gln Asn Glu Leu Trp Lys Leu Gln Arg Gln Thr Arg Glu Val Met Asn 
        35                  40                  45              


Arg Thr Ile Gln Leu Cys Tyr His Trp Ser Tyr Val Gln Ala Asp Tyr 
    50                  55                  60                  


Cys Lys Gln His Gly Cys Ala Arg Arg Asp Val Lys Pro Cys Asp Val 
65                  70                  75                  80  


Tyr Glu Thr Asn Ala Thr Ser Leu Asp Gly Tyr Ile Tyr Gln Leu Phe 
                85                  90                  95      


Lys Asp Glu Tyr Pro Asn Phe Leu Met Ala Asn Leu Ile Ala Thr Leu 
            100                 105                 110         


Arg Lys Ala His Gln Lys Tyr Asp Ala Leu Leu Phe Asp Ile Gln Glu 
        115                 120                 125             


Gly Asn Ser Ser Ile Pro Ser Phe Lys Lys Asp Gln Pro Leu Ile Phe 
    130                 135                 140                 


Ser Lys Glu Ala Ile Arg Leu Pro Glu Cys Leu Ser Asp Lys Arg Gln 
145                 150                 155                 160 


Ile Thr Leu Phe Cys Phe Ser Lys Pro Tyr Lys Ser Ala His Pro Thr 
                165                 170                 175     


Leu Asp Lys Ile Thr Phe Ala Val Arg Ala Arg Ser Ala Ser Glu Lys 
            180                 185                 190         


Ser Ile Phe Asp His Ile Ile Ser Gly Lys Tyr Ala Leu Gly Glu Ser 
        195                 200                 205             


Gln Leu Val Tyr Glu Lys Lys Lys Trp Phe Phe Leu Leu Ser Tyr Lys 
    210                 215                 220                 


Phe Thr Pro Glu Ser Val Asp Val Asn Pro Glu Lys Val Leu Gly Val 
225                 230                 235                 240 


Asp Leu Gly Val Val Asn Ala Leu Cys Ala Gly Ser Val Glu Asn Pro 
                245                 250                 255     


His Asp Ser Leu Phe Ile Lys Gly Thr Glu Ala Ile Glu Gln Ile Arg 
            260                 265                 270         


Arg Leu Glu Ala Arg Lys Arg Asp Leu Gln Lys Gln Ala Arg Tyr Pro 
        275                 280                 285             


Gly Asp Gly Arg Ile Gly His Gly Thr Lys Thr Arg Val Ser Pro Val 
    290                 295                 300                 


Tyr Gln Thr Arg Asp Ala Ile Ala Arg Met Gln Asp Thr Leu Asn His 
305                 310                 315                 320 


Arg Trp Ser Arg Ala Leu Ile Asp Phe Ala Cys Lys Lys Gly Tyr Gly 
                325                 330                 335     


Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Ala Leu Glu Ser Glu 
            340                 345                 350         


Lys Pro Tyr Leu Lys His Trp Thr Tyr Phe Asp Leu Gln Ser Lys Ile 
        355                 360                 365             


Ile Tyr Lys Ala Glu Glu Lys Gly Ile Arg Val Val Lys Val Asn Pro 
    370                 375                 380                 


Lys Cys Thr Ser Arg Arg Cys Ser Ala Cys Gly Tyr Ile Ser Lys Glu 
385                 390                 395                 400 


Asn Arg Lys Asn Gln Val Glu Phe Leu Cys Val Asn Cys Gly Tyr His 
                405                 410                 415     


His Asn Ala Asp Tyr Asn Ala Ala Gln Asn Leu Ser Ile Pro Gln Ile 
            420                 425                 430         


Asp Arg Leu Ile Glu Lys Gln Leu Lys Glu Gln Glu Ser Glu Glu Asn 
        435                 440                 445             


Glu Ala Gly Ala Asn Pro Lys 
    450                 455 


<210>  2
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.280604

<400>  2

Met Ala Lys Gly Thr Leu Ser Lys Val Met Lys Tyr Glu Leu Arg Tyr 
1               5                   10                  15      


Leu Asp Gly Cys Gly Asp Phe Gln Asn Met Gln Lys Glu Leu Trp Thr 
            20                  25                  30          


Leu Gln Arg Gln Ser Arg Glu Ile Leu Asn Arg Thr Ile Gln Ile Ala 
        35                  40                  45              


Tyr His Trp Asp Tyr Thr Asp Arg Glu Gln Phe Lys Lys Thr Gly Gln 
    50                  55                  60                  


His Leu Asp Ile Lys Ala Glu Thr Gly Tyr Lys Arg Leu Asp Gly Tyr 
65                  70                  75                  80  


Ile Tyr Asp Ser Leu Lys Glu Asp Val Gln Asn Phe Ala Ser Val Asn 
                85                  90                  95      


Val Asn Ala Thr Ile Gln Lys Ala Trp Ala Lys Tyr Lys Ser Ser Lys 
            100                 105                 110         


Ile Asp Val Leu Arg Gly Asp Met Ser Leu Pro Ser Tyr Lys Ser Asp 
        115                 120                 125             


Gln Pro Leu Val Leu His Ala Gln Ser Met Lys Ile Phe Ser Ser Asp 
    130                 135                 140                 


Asp Asp Asp Val Leu Gln Val Thr Leu Phe Ser Asn Ala Tyr Lys Lys 
145                 150                 155                 160 


Ala Cys Asn Tyr Ser Asn Ile Arg Phe Ile Ile Gly Leu His Asp Ala 
                165                 170                 175     


Thr Gln Arg Thr Ile Ile Lys Lys Val Leu Ser Gly Asp Trp Gly Ile 
            180                 185                 190         


Gly Gln Ser Gln Ile Val Tyr Lys Arg Pro Lys Trp Phe Leu Tyr Leu 
        195                 200                 205             


Thr Tyr Asn Phe Ser Pro Glu Gln His Glu Val Asn Pro Asp Lys Ile 
    210                 215                 220                 


Leu Gly Val Asp Leu Gly Glu Ser Ile Ala Ile Tyr Ala Ser Ser Ile 
225                 230                 235                 240 


Gly Glu Tyr Gly Ser Leu Arg Ile Glu Gly Gly Glu Ile Ser Ala Phe 
                245                 250                 255     


Ala Lys Gln Leu Glu Ala Arg Lys Arg Ser Leu Gln Lys Gln Ala Ala 
            260                 265                 270         


Tyr Cys Gly Lys Gly Arg Ile Gly His Gly Thr Lys Ser Arg Val Ser 
        275                 280                 285             


Asp Val Tyr Lys Met Glu Asp Lys Ile Ala Asn Phe Arg Asn Thr Val 
    290                 295                 300                 


Asn His Arg Tyr Ser Lys Met Leu Ile Asp Tyr Ala Leu Lys His Met 
305                 310                 315                 320 


Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Lys Glu Thr 
                325                 330                 335     


Gly Phe Pro Lys Phe Leu Gln His Trp Thr Tyr Tyr Asp Leu Gln Gln 
            340                 345                 350         


Lys Ile Glu Ala Lys Ala Lys Glu His Gly Ile Asn Phe Ile Lys Val 
        355                 360                 365             


Asp Pro Ala Phe Thr Ser Gln Arg Cys Ser Lys Cys Gly Asn Ile Asp 
    370                 375                 380                 


Ser Glu Asn Arg Pro Ser Gln Ala Val Phe Cys Cys Lys Lys Cys Gly 
385                 390                 395                 400 


Tyr Lys Thr Asn Ala Asp Phe Asn Ala Ser 
                405                 410 


<210>  3
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.281060

<400>  3

Met Asn Val Thr Lys Val Met Arg Tyr Gln Leu Ile Tyr Gln Gly Gly 
1               5                   10                  15      


Gly Gly Asp Phe Glu Ser Leu Gln Asn Gln Leu Trp Glu Phe Gln Arg 
            20                  25                  30          


Gln Thr Arg Ala Ile Leu Asn Lys Thr Ile Gln Thr Met Tyr Leu Ala 
        35                  40                  45              


Thr Ala Asn Gln Glu Lys Phe Ser Glu Lys Ala Leu Tyr His Asp Leu 
    50                  55                  60                  


Cys Ala Glu Tyr Pro Asp Met Ile Ser Ser Thr Val Asn Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Ala Thr Lys Lys Tyr Arg Ser Ser Val Arg Glu Ile Leu Ala 
                85                  90                  95      


Gly Arg Met Ser Leu Pro Ser Tyr Lys Arg Asp His Pro Ile Leu Leu 
            100                 105                 110         


His Asn Gln Ser Val Ala Leu Lys Gln Gly Asn Gln Gly Ser Tyr Phe 
        115                 120                 125             


Ala Thr Ile Ser Val Phe Ser Arg Lys Tyr Gln Gln Gly Thr Pro Gly 
    130                 135                 140                 


Val Lys Gln Pro Ser Phe Gln Leu Ile Ala Lys Asp Asn Thr Gln Arg 
145                 150                 155                 160 


Thr Ile Leu Gln Arg Leu Leu Ser Gly Glu Tyr Lys Leu Gly Gln Cys 
                165                 170                 175     


Gln Leu Ile Tyr Ile Arg Pro Lys Trp Phe Leu Asn Val Ala Tyr Ser 
            180                 185                 190         


Phe Thr Pro Ser Glu Lys Ala Leu Asp Gln Glu Lys Val Leu Gly Val 
        195                 200                 205             


Asp Leu Gly Cys Val Tyr Ala Ile Tyr Ala Ser Ser Tyr Gly Asn His 
    210                 215                 220                 


Gly Ile Phe Lys Ile Ser Gly Asp Glu Ile Thr Ser Phe Glu Arg Lys 
225                 230                 235                 240 


Gln Ala Ala Ile Gln Asn Arg Ala Phe Lys Asn Asp Leu Thr Arg Ile 
                245                 250                 255     


Arg Glu Ile Glu Glu Arg Arg Lys Gln Lys Leu Glu Gln Ala Arg Tyr 
            260                 265                 270         


Cys Gly Glu Gly Arg Ile Gly His Gly Val Lys Thr Arg Val Ala Pro 
        275                 280                 285             


Ala Tyr Gln Asp Glu Gly Lys Ile Ser Arg Phe Arg Glu Thr Ile Asn 
    290                 295                 300                 


His Arg Tyr Ser Lys Ala Leu Val Asp Tyr Ala Glu Lys Asn Gly Tyr 
305                 310                 315                 320 


Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Ser Ser Thr Gly 
                325                 330                 335     


Phe Pro Lys Arg Leu Gln His Trp Thr Tyr Phe Asp Leu Gln Gln Lys 
            340                 345                 350         


Ile Lys Tyr Lys Ala Glu Glu Gln Gly Ile Lys Val Val Lys Ile Lys 
        355                 360                 365             


Pro Ala Tyr Thr Ser Gln Arg Cys Ser Arg Cys Gly His Ile Asp Pro 
    370                 375                 380                 


Ala Asn Arg Lys Ser Gln Ser Glu Phe Lys Cys Ile Ala Cys Gly Phe 
385                 390                 395                 400 


Ser Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ser Met Arg Asn 
                405                 410                 415     


Ile Glu Lys Ile Ile Gln Gly Lys Ala Asn 
            420                 425     


<210>  4
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.284933

<400>  4

Met Ala Lys Gly Thr Ile Thr Lys Val Met Lys Tyr Glu Leu Arg Tyr 
1               5                   10                  15      


Leu Gly Gly Phe Ser Asp Phe His Glu Met Gln Lys Glu Val Trp Gln 
            20                  25                  30          


Leu Gln Arg Gln Tyr Arg Glu Ile Leu Asn Lys Thr Ile Gln Ile Ala 
        35                  40                  45              


Leu His Trp Asp Tyr Val Ser Ala Gln Gln Phe Gly Glu Ser Gly Thr 
    50                  55                  60                  


Tyr Leu Asp Ile Arg Glu Glu Thr Gly Tyr Lys Thr Leu Asp Gly Tyr 
65                  70                  75                  80  


Ile Tyr Asn Cys Leu Lys Gly Ala Tyr Ser Glu Met Ala Ser Ala Asn 
                85                  90                  95      


Leu Asn Ala Ala Val Gln Lys Ala Trp Lys Lys Tyr Lys Asn Ser Lys 
            100                 105                 110         


Thr Gln Val Leu Gln Gly Val Met Ser Leu Pro Ser Tyr Lys Ser Asp 
        115                 120                 125             


Gln Pro Ile Leu Ile Asp Lys Gly Asn Val Lys Leu Ser Ala Glu Glu 
    130                 135                 140                 


Asn Asn Gly Arg Ala Val Leu Thr Leu Phe Ser Arg Asn Tyr Arg Asp 
145                 150                 155                 160 


Thr Arg Gly Leu Lys Gly Asn Val Glu Phe Ser Val Leu Leu His Asp 
                165                 170                 175     


Gly Thr Gln Lys Ser Ile Phe Arg Asn Leu Ile Asp Lys Thr Tyr Ala 
            180                 185                 190         


Leu Gly Gln Cys Gln Leu Val Tyr Glu Arg Lys Lys Trp Phe Leu Leu 
        195                 200                 205             


Leu Thr Tyr Ser Phe Thr Pro Ala Gly His Ala Leu Asp Pro Glu Lys 
    210                 215                 220                 


Ile Leu Gly Val Asp Leu Gly Glu Cys Tyr Ala Leu Tyr Ala Ser Ser 
225                 230                 235                 240 


Cys Tyr Ala Pro Gly Ile Leu Lys Ile Glu Gly Gly Glu Ile Ala Glu 
                245                 250                 255     


Tyr Ala Leu Arg Leu Glu Lys Arg Lys Arg Ser Leu Gln Gln Gln Ala 
            260                 265                 270         


Arg Tyr Cys Gly Glu Gly Arg Ile Gly His Gly Thr Lys Thr Arg Val 
        275                 280                 285             


Gly Val Val Tyr Lys Ala Glu Asp Arg Ile Ala Ser Phe Arg Glu Thr 
    290                 295                 300                 


Ile Asn His Arg Tyr Ser Lys Glu Leu Val Asp Tyr Ala Val Ser Asn 
305                 310                 315                 320 


Gly Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Ala Ile Gln Lys Asp 
                325                 330                 335     


Leu Gly Phe Pro Lys Arg Leu Arg His Trp Thr Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Met Lys Ile Thr Asn Lys Ala Lys Glu His Gly Ile Ala Val Val Lys 
        355                 360                 365             


Ile Asp Pro Arg Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly His Ile 
    370                 375                 380                 


Asp Pro Ala Asn Arg Pro Arg Gln Glu Glu Phe Cys Cys Thr Ala Cys 
385                 390                 395                 400 


Gly Tyr Ala Cys Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ser Ile 
                405                 410                 415     


Lys Gly Ile Glu Lys Ile Ile Gln Lys Met Leu Ser Ala Lys Ala Asp 
            420                 425                 430         


<210>  5
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.287908

<400>  5

Met Ser Lys Gly Met Leu Thr Lys Val Met Lys Tyr Thr Leu Arg Tyr 
1               5                   10                  15      


Val Gly Gly Cys Gly Asp Phe His Glu Met Gln Ser Ile Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Ala Val Leu Asn Lys Thr Ile Gln Ile Ala 
        35                  40                  45              


Phe Glu Trp Asp Tyr Arg Ser Arg Glu Ala Phe Gln Glu Thr Gly Glu 
    50                  55                  60                  


Tyr Leu Asp Val His Ala Glu Thr Gly Tyr Lys Arg Leu Asp Gly Tyr 
65                  70                  75                  80  


Ile Tyr Asn Cys Leu Lys Asn Glu Tyr Ala Asp Phe Ala Gly Lys Asn 
                85                  90                  95      


Leu Asn Ala Ala Ile Gln Thr Ala Trp Lys Lys Tyr Asn Gln Ser Lys 
            100                 105                 110         


Arg Asp Ile Gln Thr Gly Lys Met Ser Leu Pro Ser Tyr Arg Ser Asn 
        115                 120                 125             


Gln Pro Leu Ile Ile His Asn Asp Asn Val Met Ile Ser Gln Asp Met 
    130                 135                 140                 


Gln Ala Ala Pro Ser Val Arg Phe Thr Leu Leu Ser Leu Glu Tyr Lys 
145                 150                 155                 160 


Lys Ala His Asp Leu Asn Thr Asn Pro Thr Phe Glu Val Leu Ile Asn 
                165                 170                 175     


Asp Gly Thr Gln Arg Ala Ile Phe Glu Lys Val Arg Ser Gly Glu Tyr 
            180                 185                 190         


Lys Leu Gly Gln Cys Met Ile Gln Tyr Asp Lys Lys Lys Trp Phe Leu 
        195                 200                 205             


Leu Leu Thr Tyr Ser Phe Gln Pro Glu Lys Leu Thr Leu Asp Lys Asn 
    210                 215                 220                 


Lys Ile Leu Gly Val Asp Leu Gly Glu Thr Ile Val Ile Cys Ala Ser 
225                 230                 235                 240 


Ser Val Ser Glu Arg Gly Arg Phe Val Ile Asp Gly Gly Glu Ile Thr 
                245                 250                 255     


Arg Phe Ala Thr Gln Ile Glu Ala Arg Lys Arg Ser Gln Gln His Gln 
            260                 265                 270         


Ala Ala Tyr Cys Gly Glu Gly Arg Ile Gly His Gly Thr Lys Thr Arg 
        275                 280                 285             


Val Asp Ala Val Tyr Lys Thr Glu Asp Arg Ile Ala Asn Phe Arg Asp 
    290                 295                 300                 


Thr Ile Asn His Arg Tyr Ser Arg Ala Leu Val Asn Tyr Ala Val Lys 
305                 310                 315                 320 


His Gly Phe Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Ser 
                325                 330                 335     


Ser Asp Asp Phe Pro Lys Phe Leu Arg His Trp Thr Tyr Tyr Asp Leu 
            340                 345                 350         


Gln Ser Lys Ile Glu Ser Lys Ala Lys Glu Arg Gly Ile Ala Val Val 
        355                 360                 365             


Lys Val Asn Pro Arg Phe Thr Ser Arg Arg Cys Ser Lys Cys Gly Tyr 
    370                 375                 380                 


Ile Asp Glu Gly Asn Arg Lys Asp Gln Ala His Phe Cys Cys Leu Ser 
385                 390                 395                 400 


Cys Gly Phe Arg Ala Asn Ala Asp Phe Asn Ala Ser Gln Asn Leu Ser 
                405                 410                 415     


Ile Lys Gly Ile Asp Lys Ile Ile Glu Lys Glu Tyr Asn Ala Asn Ser 
            420                 425                 430         


Lys Gln Thr 
        435 


<210>  6
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.288518

<400>  6

Met Gly Lys Pro Ile Thr Lys Thr Met Lys Tyr Gln Ile His Tyr Ile 
1               5                   10                  15      


Asp Gly Cys Gly Asp Phe His Asn Met Gln Lys Glu Leu Trp Asp Leu 
            20                  25                  30          


Gln Arg Ile Val Arg Gln Ile Leu Asn Lys Thr Ile Asn Glu Ser Tyr 
        35                  40                  45              


Leu Trp Phe Val Arg Ser Glu Gln Tyr Tyr Arg Asp Thr Gly Glu Asn 
    50                  55                  60                  


Leu Ser Val Glu Glu Gln Thr Gly Tyr Lys Thr Leu Asp Gly His Ile 
65                  70                  75                  80  


Tyr Asn Leu Leu Lys Gln Glu Tyr Thr Gln Lys Leu Val Ser Asn Ser 
                85                  90                  95      


Leu Asn Ala Ser Ile Gln Ala Ala Tyr Lys Lys Met Lys Asp Ser Arg 
            100                 105                 110         


Arg Asp Val Met Ile Gly Thr Met Ser Leu Pro Ser Tyr Arg Ser Asp 
        115                 120                 125             


Gln Pro Ile Ile Ile Tyr Asn Lys Asn Ile Lys Phe Ser Ser His Pro 
    130                 135                 140                 


Glu His Gly Phe Val Val Asp Cys Ser Leu Phe Ser Asp Ala Tyr Lys 
145                 150                 155                 160 


Lys Ser Gln Gly Tyr Glu Lys Ser Val Lys Phe Gln Val Ser Val Asp 
                165                 170                 175     


Asp Asn Thr Gln Arg Ser Ile Phe Glu Asn Ile Leu Thr Gly Asn Tyr 
            180                 185                 190         


Lys His Gly Gln Cys Ser Ile Val Tyr Glu Lys Lys Lys Trp Phe Leu 
        195                 200                 205             


Leu Leu Thr Tyr Ser Phe Val Pro Glu Glu Thr Lys Leu Asp Pro Asp 
    210                 215                 220                 


Lys Ile Leu Gly Val Asp Val Gly Val Val Tyr Ala Leu Tyr Ala Ser 
225                 230                 235                 240 


Ser Lys Gly Asn His Gly Thr Phe Lys Ile Lys Gly Asp Glu Ala Ile 
                245                 250                 255     


Thr Phe Ile Gln Arg Val Glu Ala Arg Lys His Ser Arg Gln Leu Gln 
            260                 265                 270         


Gly Thr Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Thr Lys Thr Arg 
        275                 280                 285             


Val Gln Pro Val Tyr Asn Glu Arg Ala Leu Ile Ser Asn Phe Gln Asp 
    290                 295                 300                 


Thr Ile Asn His Arg Tyr Ser Lys Ala Leu Ile Asp Tyr Ala Lys Lys 
305                 310                 315                 320 


Asn Gly Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Glu 
                325                 330                 335     


Val Gln Gln Tyr Pro Lys Tyr Leu Gln His Trp Thr Tyr Tyr Asp Leu 
            340                 345                 350         


Gln Leu Lys Ile Gln Tyr Lys Ala Lys Glu Ala Gly Ile Gly Phe Val 
        355                 360                 365             


Lys Val Thr Pro Lys Tyr Thr Ser Gln Arg Cys Ser His Cys Gly Asn 
    370                 375                 380                 


Ile Asp Glu Ala Asn Arg Pro Lys Gln Asp Val Phe Arg Cys Thr Val 
385                 390                 395                 400 


Cys Gly Tyr Glu Arg Asn Ala Asp Tyr Asn Ala Ser Gln Asn Leu Ser 
                405                 410                 415     


Ile Lys Gly Ile Asp Arg Ile Ile Asp Asp Gln Leu Lys Gln Met Asn 
            420                 425                 430         


Lys Ala Asn Pro Lys Lys Thr Glu Asn Ala 
        435                 440         


<210>  7
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.293891

<400>  7

Met Ser Gly Gly Ala Ile Thr Lys Val Met Lys Tyr Asp Leu Thr Tyr 
1               5                   10                  15      


Lys Asp Gly Tyr Gly Asn Phe Lys Asp Met Gln Glu Ala Val Trp Lys 
            20                  25                  30          


Leu Ile Arg Asp Thr Arg Thr Ile Leu Asn Glu Thr Ile Lys Ile Ala 
        35                  40                  45              


Tyr His Trp Asp Tyr Leu Asn Glu Lys Ser Lys Arg Glu Thr Gly Glu 
    50                  55                  60                  


His Leu Asp Leu Leu Glu Glu Thr Gly Tyr Lys Arg Leu Asp Gly Tyr 
65                  70                  75                  80  


Ile Tyr Asp Asp Leu Lys Asp Arg Phe Pro Asp Phe Ala Ser Ser Asn 
                85                  90                  95      


Leu Asn Ala Ala Ile Gln Thr Ala Trp Lys Lys Tyr Lys Gln Ser Gln 
            100                 105                 110         


Lys Asp Val Tyr Ile Gly Lys Met Thr Leu Pro Ser Tyr Lys Ser Asp 
        115                 120                 125             


Gln Pro Leu Pro Ile Asn Lys Gln Ser Ile Lys Ile Tyr Asp Glu Glu 
    130                 135                 140                 


Arg Glu His Ile Val Glu Leu Asn Leu Phe Ser Thr Lys His Lys Lys 
145                 150                 155                 160 


Glu His Gly Leu Ala Ser Asn Val Arg Phe Arg Ile Asn Leu His Asp 
                165                 170                 175     


Asn Thr Gln His Ala Ile Tyr Glu Arg Val Leu Ser Gly Glu Tyr Thr 
            180                 185                 190         


Leu Gly Gln Cys Gln Leu Leu Tyr Asp Arg Pro Lys Trp Phe Phe Ile 
        195                 200                 205             


Leu Thr Tyr Ser Phe Lys Pro Ala Gln Asn Lys Leu Asp Pro Asp Lys 
    210                 215                 220                 


Ile Leu Gly Val Asp Met Gly Glu Thr Cys Ala Leu Tyr Ala Ser Thr 
225                 230                 235                 240 


Phe Gly Glu Gln Gly Ser Phe Val Ile Asn Gly Gly Glu Val Ser Glu 
                245                 250                 255     


Tyr Ala Lys Arg Glu Glu Ala Arg Lys Arg Ser Leu Gln Lys Gln Ala 
            260                 265                 270         


Ala Val Cys Gly Glu Gly Arg Ile Gly His Gly Thr Lys Thr Arg Val 
        275                 280                 285             


Ser Ser Val Tyr Lys Glu Gln Glu Arg Ile Ser Asn Phe Arg Asp Thr 
    290                 295                 300                 


Ile Asn His Arg Tyr Ser Lys Ala Leu Ile Glu Tyr Ala Val Lys Asn 
305                 310                 315                 320 


Gly Cys Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Arg Gln Ser 
                325                 330                 335     


Thr Asp Phe Pro Lys Phe Leu Arg His Trp Thr Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Gln Lys Ile Lys Thr Lys Ala Lys Glu Thr Gly Ile Ala Val Ser Met 
        355                 360                 365             


Ile Asp Pro Arg Tyr Thr Ser Gln Arg Cys Ser Arg Cys Gly His Ile 
    370                 375                 380                 


Asp Lys Ala Asn Arg Lys Asp Gln Ala His Phe His Cys Leu Lys Cys 
385                 390                 395                 400 


Gly Tyr Ser Cys Asn Ala Asp Phe Asn Ala Ser Gln Asn Ile Ser Ile 
                405                 410                 415     


Arg Gly Ile Asp Lys Ile Ile Gln Lys Glu Leu Gly Ala Lys Ala Lys 
            420                 425                 430         


Gln Thr Asp 
        435 


<210>  8
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.294270

<400>  8

Met Lys Glu Ile Ala Lys Val Met Lys Tyr Gln Leu Ile Tyr Leu Asp 
1               5                   10                  15      


Gly Gly Gly Asp Phe Tyr Glu Leu Gln Gln Thr Leu Trp Asp Leu Gln 
            20                  25                  30          


Arg Gln Thr Arg Glu Ile Leu Asn Lys Thr Ile Gln Ser Met Tyr Leu 
        35                  40                  45              


Ala Thr Ala Thr Asn Thr Ala Phe Glu Glu Asn Ala Leu Tyr His Arg 
    50                  55                  60                  


Phe Gly Ala Glu Tyr Pro Met Met Ala Ala Leu Asn Val Asn Ala Thr 
65                  70                  75                  80  


Leu Arg Thr Ala Lys Lys Arg Tyr Thr Ser Thr Ile Lys Glu Thr Leu 
                85                  90                  95      


Arg Gly Thr Met Ser Leu Pro Ser Tyr Lys Arg Asp Gln Pro Ile Leu 
            100                 105                 110         


Leu His Asn Gln Thr Ile His Leu Ala Leu Glu Asp Gly Gln Tyr Ser 
        115                 120                 125             


Ala Leu Phe Ser Val Tyr Ser Glu Lys Phe Gln Lys Ala His Glu Gly 
    130                 135                 140                 


Val Ala Arg Pro Arg Phe Ala Leu Met Ala Arg Asp Gly Thr Gln Arg 
145                 150                 155                 160 


Ala Ile Leu Asp Arg Leu Leu Asp Gly Ser Tyr Arg Leu Gly Gln Ser 
                165                 170                 175     


Gln Met Thr Tyr Glu Gln Lys Lys Trp Phe Leu Ser Leu Thr Tyr Lys 
            180                 185                 190         


Phe Val Pro Glu Val Arg Glu Leu Asp Lys Ser Lys Ile Leu Gly Val 
        195                 200                 205             


Asp Leu Gly Cys Val Tyr Ala Ile Tyr Ala Ser Ser Met Gln Gln Lys 
    210                 215                 220                 


Gly Ile Phe Lys Ile Ser Gly Asp Glu Ile Thr Glu Phe Glu Lys Arg 
225                 230                 235                 240 


Gln Ala Ala Met Gln Asn Arg Glu Pro Val Ser Thr Leu Glu Arg Val 
                245                 250                 255     


Glu Gln Leu Glu Gln Arg Arg Trp Gln Lys Gln Gln Gln Ala Arg Tyr 
            260                 265                 270         


Cys Gly Glu Gly Arg Val Gly His Gly Thr Gly Thr Arg Val Ala Pro 
        275                 280                 285             


Ala Tyr Arg Asp Ala Asp Lys Ile Ala Arg Phe Arg Asp Thr Ile Asn 
    290                 295                 300                 


His Arg Tyr Ser Lys Ala Leu Val Glu Tyr Ala Glu Lys Asn Gly Phe 
305                 310                 315                 320 


Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Glu Asp Thr Gly 
                325                 330                 335     


Phe Pro Lys Arg Leu Arg His Trp Thr Tyr Phe Asp Leu Gln Thr Lys 
            340                 345                 350         


Ile Gln Tyr Lys Ala Ala Glu Arg Gly Ile Thr Val Val Lys Ile Asp 
        355                 360                 365             


Pro Gln Tyr Thr Ser Gln Arg Cys Ser Arg Cys Gly Tyr Ile Asp Lys 
    370                 375                 380                 


Ala Asn Arg Ala Ser Gln Glu Lys Phe Leu Cys Gln Ser Cys Gly Phe 
385                 390                 395                 400 


Glu Ala Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ser Val Glu Lys 
                405                 410                 415     


Ile Asp Lys Leu Ile Ala Lys Asp Lys Lys Lys Leu Ala Arg Thr 
            420                 425                 430     


<210>  9
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.294491

<400>  9

Met Gly Gln Val Thr Lys Val Met Arg Tyr Gln Leu Ile Tyr Gln Asp 
1               5                   10                  15      


Gly Gly Gly Asp Phe Tyr Thr Val Gln Gln Glu Leu Trp Glu Leu Gln 
            20                  25                  30          


Arg Gln Thr Arg Glu Ile Leu Asn Lys Thr Ile Gln Thr Met Tyr Leu 
        35                  40                  45              


Ala Asp Ala Asn Lys Glu Lys Phe Asp Asn Ala Ala Glu Arg Thr Leu 
    50                  55                  60                  


Asn Arg Arg Phe Cys Val Asp His Pro Asp Met Tyr Thr Lys Thr Val 
65                  70                  75                  80  


Thr Ala Thr Leu Arg Lys Ala Lys Ala Lys Tyr Asn Ala Ser Gln Lys 
                85                  90                  95      


Glu Ile Leu Ala Gly Arg Met Ser Leu Pro Ser Tyr Lys Arg Asp Gln 
            100                 105                 110         


Pro Ile Leu Leu Asn Pro Gln Gly Phe Lys Ile Glu Glu Glu Ser Asp 
        115                 120                 125             


Ser Phe Phe Ala Ala Ile Ala Val Phe Ser Asp Lys Tyr Lys Asn Lys 
    130                 135                 140                 


His Pro Asp Val Asp Val Lys Arg Leu Arg Phe Arg Leu Val Val Lys 
145                 150                 155                 160 


Asp Gly Thr Gln Arg Ala Ile Ile Arg Arg Val Ile Ser Gly Glu Tyr 
                165                 170                 175     


Lys Leu Gly Arg Ser Gln Leu Leu Tyr Ser Lys Lys Lys Trp Phe Leu 
            180                 185                 190         


Asn Val Thr Tyr Ser Phe Glu Pro Ala Glu Lys Lys Val Asp Pro Asp 
        195                 200                 205             


Lys Ile Leu Gly Val Asp Leu Gly Cys Val Tyr Ala Ile Tyr Ala Ser 
    210                 215                 220                 


Ser Phe Gly Ser Pro Gly Val Phe Lys Ile Ser Gly Asp Glu Val Ser 
225                 230                 235                 240 


Ser Phe Glu Arg Lys Gln Ala Ala Ile Gln Asn Arg Ser Pro Lys Ser 
                245                 250                 255     


Thr Leu Glu Arg Val Glu Lys Ile Glu Glu Arg His Lys Gln Lys Gln 
            260                 265                 270         


Gln Gln Ala Arg Tyr Cys Gly Glu Gly Arg Ile Gly His Gly Thr Lys 
        275                 280                 285             


Thr Arg Ile Ala Pro Val Tyr Gln Asp Glu Asp Lys Ile Ala Arg Phe 
    290                 295                 300                 


Arg Asp Thr Val Asn His Arg Tyr Ser Lys Ala Leu Ile Asp Tyr Ala 
305                 310                 315                 320 


Glu Lys Asn Gly Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile 
                325                 330                 335     


Lys Ser Ala Thr Gly Phe Pro Lys Arg Leu Lys His Trp Thr Tyr Tyr 
            340                 345                 350         


Asp Leu Gln Thr Lys Ile Glu Tyr Lys Ala Glu Glu Arg Gly Ile Lys 
        355                 360                 365             


Val Val Lys Ile Asp Pro Arg Tyr Thr Ser Gln Arg Cys Ser Arg Cys 
    370                 375                 380                 


Gly Tyr Ile Asp Ser Gly Asn Arg Lys Ser Gln Ala Glu Phe Cys Cys 
385                 390                 395                 400 


Met Ala Cys Gly Phe Ser Cys Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
                405                 410                 415     


Ile Ser Ile Gly Gly Ile Ala Lys Ile Ile Ala Asp Lys Arg Lys Glu 
            420                 425                 430         


Ala Asp Ala Lys 
        435     


<210>  10
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.295047

<400>  10

Tyr Leu Asp Ile Arg Glu Glu Thr Gly Tyr Lys Thr Leu Asp Gly Tyr 
1               5                   10                  15      


Ile Tyr Asn Cys Leu Lys Gly Ala Tyr Ser Glu Met Ala Ser Ala Asn 
            20                  25                  30          


Leu Asn Ala Ala Val Gln Lys Ala Trp Lys Lys Tyr Lys Asn Ser Lys 
        35                  40                  45              


Thr Gln Val Leu Gln Gly Val Met Ser Leu Pro Ser Tyr Lys Ser Asp 
    50                  55                  60                  


Gln Pro Ile Leu Ile Asp Lys Gly Asn Val Lys Leu Ser Ala Glu Glu 
65                  70                  75                  80  


Asn Asn Gly Arg Ala Val Leu Thr Leu Phe Ser Arg Asn Tyr Arg Asp 
                85                  90                  95      


Thr Arg Gly Leu Lys Gly Asn Val Glu Phe Ser Val Leu Leu His Asp 
            100                 105                 110         


Gly Thr Gln Lys Ser Ile Phe Arg Asn Leu Ile Asp Lys Thr Tyr Ala 
        115                 120                 125             


Leu Gly Gln Cys Gln Leu Val Tyr Glu Arg Lys Lys Trp Phe Leu Leu 
    130                 135                 140                 


Leu Thr Tyr Ser Phe Thr Pro Ala Gly His Ala Leu Asp Pro Glu Lys 
145                 150                 155                 160 


Ile Leu Gly Val Asp Leu Gly Glu Cys Tyr Ala Leu Tyr Ala Ser Ser 
                165                 170                 175     


Cys Tyr Ala Pro Gly Ile Leu Lys Ile Glu Gly Gly Glu Ile Ala Glu 
            180                 185                 190         


Tyr Ala Leu Arg Leu Glu Lys Arg Lys Arg Ser Leu Gln Gln Gln Ala 
        195                 200                 205             


Arg Tyr Cys Gly Glu Gly Arg Ile Gly His Gly Thr Lys Thr Arg Val 
    210                 215                 220                 


Gly Val Val Tyr Lys Ala Glu Asp Arg Ile Ala Ser Phe Arg Glu Thr 
225                 230                 235                 240 


Ile Asn His Arg Tyr Ser Lys Glu Leu Val Asp Tyr Ala Val Ser Asn 
                245                 250                 255     


Gly Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Ala Ile Gln Lys Asp 
            260                 265                 270         


Leu Gly Phe Pro Lys Arg Leu Arg His Trp Thr Tyr Tyr Asp Leu Gln 
        275                 280                 285             


Met Lys Ile Thr Asn Lys Ala Lys Glu His Gly Ile Ala Val Val Lys 
    290                 295                 300                 


Ile Asp Pro Arg Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly His Ile 
305                 310                 315                 320 


Asp Pro Ala Asn Arg Pro Arg Gln Glu Glu Phe Cys Cys Thr Ala Cys 
                325                 330                 335     


Gly Tyr Ala Cys Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ser Ile 
            340                 345                 350         


Lys Gly Ile Glu Lys Ile Ile Gln Lys Met Leu Ser Ala Lys Ala Asp 
        355                 360                 365             


<210>  11
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.299588

<400>  11

Met Ala Glu Lys Thr Ile Val Lys Val Met Lys Phe Glu Leu Arg Tyr 
1               5                   10                  15      


Ile Asp Gly Ala Gly Glu Phe Ser Glu Met Gln Lys His Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Glu Val Leu Asn Lys Thr Ile Gln Met Gly 
        35                  40                  45              


Tyr Ala Leu Glu Cys Lys Arg Phe Ala His His Asp Lys Thr Gly Gln 
    50                  55                  60                  


Trp Leu Asp Asp Lys Glu Leu Thr Gly Ser Lys Tyr Lys Ala Val Ala 
65                  70                  75                  80  


Asp Tyr Ile Asn Ala Glu Leu Lys Glu Asp Tyr Asn Ile Phe Tyr Ser 
                85                  90                  95      


Asp Cys Arg Asn Ser Thr Val Arg Lys Ala Tyr Lys Lys Phe Lys Asp 
            100                 105                 110         


Ala Lys Asn Lys Ile Phe Ser Gly Glu Met Ser Leu Pro Ser Tyr Arg 
        115                 120                 125             


Ser Asn Gln Pro Ile Ile Ile His Asn Arg Asn Val Ile Ile Arg Gly 
    130                 135                 140                 


Asn Ala Glu Ser Ala Leu Val Gly Leu Lys Val Phe Ser Asp Gly Phe 
145                 150                 155                 160 


Lys Ala Leu His Gly Phe Pro Ala Ala Val Asn Phe Lys Leu Cys Val 
                165                 170                 175     


Lys Asp Gly Thr Gln Arg Ala Ile Ile Glu Asn Val Ile Ser Glu Ile 
            180                 185                 190         


Tyr Lys Ile Ser Glu Ser Gln Leu Ile Tyr Asp Asn Lys Lys Trp Phe 
        195                 200                 205             


Leu Ile Leu Ala Tyr Arg Phe Thr Gln Lys Lys Asn Asp Leu Asn Pro 
    210                 215                 220                 


Asp Lys Ile Leu Gly Val Asp Leu Gly Val Lys Phe Ala Val Tyr Ala 
225                 230                 235                 240 


Ser Ser Ile Gly Glu Tyr Gly Ser Phe Arg Ile Lys Gly Gly Glu Val 
                245                 250                 255     


Thr Glu Phe Ile Lys Arg Leu Glu Lys Arg Lys Lys Ser Leu Gln Asn 
            260                 265                 270         


Gln Ala Thr Val Cys Gly Asp Gly Arg Ile Gly His Gly Thr Lys Thr 
        275                 280                 285             


Arg Val Ala Asp Val Tyr Lys Ala Arg Asp Lys Ile Ser Asn Phe Gln 
    290                 295                 300                 


Asp Thr Ile Asn His Arg Tyr Ser Arg Ala Ile Val Asp Tyr Ala Arg 
305                 310                 315                 320 


Lys Asn Gly Tyr Gly Thr Ile Gln Leu Glu Lys Leu Asp Asn Ser Ile 
                325                 330                 335     


Glu Lys Lys Gly Asp Tyr Ser Pro Val Leu Val His Trp Thr Tyr Tyr 
            340                 345                 350         


Asp Leu Arg Thr Lys Met Glu Tyr Lys Ala Ala Glu Tyr Gly Ile Lys 
        355                 360                 365             


Val Ile Ala Val Glu Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys 
    370                 375                 380                 


Gly Tyr Ile Ser Ser Glu Asn Arg Lys Thr Gln Glu Ser Phe Glu Cys 
385                 390                 395                 400 


Ile Lys Cys Gly Tyr Lys Cys Asn Ala Asp Phe Asn Ala Ser Gln Asn 
                405                 410                 415     


Leu Ser Val Arg Asp Ile Asp Arg Ile Ile Asp Glu Tyr Leu Gly Ala 
            420                 425                 430         


Asn Pro Glu Leu Thr 
        435         


<210>  12
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.277328

<400>  12

Val Val Asn Val Ala Lys Gly Ala Leu Ser Lys Val Met Lys Phe Glu 
1               5                   10                  15      


Leu Ser Tyr Leu Asp Gly Cys Gly Asp Phe Gln Asn Met Gln Lys Glu 
            20                  25                  30          


Leu Trp Thr Leu Gln Arg Gln Thr Arg Glu Ile Leu Asn Arg Thr Ile 
        35                  40                  45              


Gln Ile Ala Tyr His Trp Asp Tyr Thr Asp Arg Glu His Phe Lys Lys 
    50                  55                  60                  


Thr Gly Gln His Leu Asp Val Lys Ser Glu Thr Gly Tyr Lys Arg Leu 
65                  70                  75                  80  


Asp Gly Tyr Ile Tyr Asp Glu Leu Lys Glu Thr Val Gln Asn Phe Ala 
                85                  90                  95      


Ser Val Asn Val Asn Ala Thr Ile Gln Lys Ala Trp Ala Lys Tyr Lys 
            100                 105                 110         


Ser Ser Lys Thr Asp Val Leu Arg Gly Asp Met Ser Leu Pro Ser Tyr 
        115                 120                 125             


Lys Ser Asp Gln Pro Leu Val Leu His Ala Gln Ser Ile Lys Leu Ser 
    130                 135                 140                 


Glu Asp Lys Asp Gly Pro Val Leu Gln Val Thr Leu Phe Ser Asn Ala 
145                 150                 155                 160 


His Lys Lys Ala Cys Asp Tyr Ser Asn Val Arg Phe Ala Phe Arg Leu 
                165                 170                 175     


His Asp Ala Thr Gln Arg Ala Ile Phe Lys Asn Val Leu Ser Gly Glu 
            180                 185                 190         


Tyr Gly Leu Gly Gln Ser Gln Ile Val Tyr Lys Arg Pro Lys Trp Phe 
        195                 200                 205             


Leu Tyr Leu Thr Tyr Asn Phe Ser Pro Glu Gln His Gly Leu Asp Pro 
    210                 215                 220                 


Asp Lys Ile Leu Gly Val Asp Leu Gly Glu Ser Ile Ala Leu Tyr Ala 
225                 230                 235                 240 


Ser Ser Leu Gly Asp Tyr Gly Ser Leu Arg Ile Glu Gly Gly Glu Val 
                245                 250                 255     


Thr Ala Phe Ala Lys Gln Leu Glu Ala Arg Lys Arg Ser Leu Gln Lys 
            260                 265                 270         


Gln Ala Ala His Cys Gly Glu Gly Arg Val Gly His Gly Thr Arg Ala 
        275                 280                 285             


Arg Val Ser Asp Val Tyr Lys Ala Glu Asp Lys Ile Ala Asn Phe Arg 
    290                 295                 300                 


Asn Thr Val Asn His Arg Tyr Ser Lys Lys Leu Ile Glu Tyr Ala Ile 
305                 310                 315                 320 


Gln Asn Arg Tyr Gly Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys 
                325                 330                 335     


Gln Asp Thr Gly Phe Pro Lys Phe Leu Gln His Trp Thr Tyr Tyr Asp 
            340                 345                 350         


Leu Gln Gln Lys Ile Glu Ala Lys Ala Lys Glu Asn Gly Ile Asn Phe 
        355                 360                 365             


Ile Lys Val Asp Pro Ser Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly 
    370                 375                 380                 


Asn Ile Asp Ser Asp Asn Arg Pro Ser Gln Ala Val Phe Cys Cys Thr 
385                 390                 395                 400 


Lys Cys Gly Phe Arg Ala Asn Ala Asp Phe Asn Ala Ser Gln Asn Leu 
                405                 410                 415     


Ser Ile Pro Glu Ile Asp Lys Ile Ile Lys Lys Glu Arg Gly Ala Asn 
            420                 425                 430         


Thr Lys 
        


<210>  13
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.297894

<400>  13

Met Ala Lys Lys Gly Thr Asn Arg Lys Lys Met Ile Val Lys Val Met 
1               5                   10                  15      


Lys Tyr Glu Leu Lys Tyr Glu Lys Gly Cys Ala Asp Phe Asn Glu Met 
            20                  25                  30          


Gln Asn Glu Leu Trp Lys Leu Gln Arg Gln Thr Arg Glu Val Met Asn 
        35                  40                  45              


Arg Thr Val Gln Leu Cys Tyr His Trp Asn Tyr Val Gln Ala Asp Tyr 
    50                  55                  60                  


Cys Lys Gln His Gly Cys Ala His Arg Asp Val Lys Pro Cys Asp Val 
65                  70                  75                  80  


Tyr Glu Thr Asn Ala Thr Ser Leu Asp Gly Tyr Ile Tyr Gln Leu Phe 
                85                  90                  95      


Lys Asp Glu Tyr Pro Asn Phe Leu Met Ala Asn Leu Ile Ala Thr Leu 
            100                 105                 110         


Arg Lys Ala His Gln Lys Tyr Asp Ala Leu Leu Pro Asp Ile Gln Glu 
        115                 120                 125             


Gly Asn Ser Ser Ile Pro Ser Phe Lys Lys Asp Gln Pro Leu Ile Phe 
    130                 135                 140                 


Ser Lys Glu Ala Ile His Leu Pro Glu Cys Leu Ser Asp Lys Arg Gln 
145                 150                 155                 160 


Ile Thr Leu Phe Cys Phe Ser Lys Pro Tyr Lys Ser Ala His Pro Thr 
                165                 170                 175     


Leu Asp Lys Ile Thr Phe Ala Val Arg Ala His Ser Ala Ser Glu Lys 
            180                 185                 190         


Ser Ile Phe Asp Asn Ile Ile Asn Gly Lys Tyr Ala Leu Gly Thr Ser 
        195                 200                 205             


Gln Leu Val Tyr Glu Lys Lys Lys Trp Phe Phe Leu Leu Ser Tyr Lys 
    210                 215                 220                 


Phe Thr Pro Glu Ser Val Asp Val Asn Pro Glu Lys Val Leu Gly Val 
225                 230                 235                 240 


Asp Leu Gly Val Val Asn Ala Leu Cys Ala Gly Ser Val Glu Asn Pro 
                245                 250                 255     


His Asp Ser Leu Phe Ile Lys Gly Thr Glu Ala Ile Glu Gln Ile Arg 
            260                 265                 270         


Arg Leu Glu Ala Arg Lys Arg Asp Leu Gln Lys Gln Ala Arg Tyr Pro 
        275                 280                 285             


Gly Asp Gly Arg Ile Gly His Gly Thr Lys Thr Arg Val Ser Pro Val 
    290                 295                 300                 


Tyr Gln Thr Arg Asp Ala Ile Ala Arg Met Gln Asp Thr Leu Asn His 
305                 310                 315                 320 


Arg Trp Ser Arg Ala Leu Ile Asp Phe Ala Cys Lys Lys Gly Tyr Gly 
                325                 330                 335     


Thr Ile Gln Met Glu Asp Leu Ser Gly Ile Lys Ala Met Glu Ser Glu 
            340                 345                 350         


Lys Pro Tyr Leu Lys His Trp Thr Tyr Phe Asp Leu Gln Ser Lys Ile 
        355                 360                 365             


Ile Tyr Lys Ala Glu Glu Lys Gly Ile Arg Val Val Lys Val Asn Pro 
    370                 375                 380                 


Lys Cys Thr Ser Arg Arg Cys Ser Ala Cys Gly Tyr Ile Ser Lys Glu 
385                 390                 395                 400 


Asn Arg Lys Asn Gln Ala Glu Phe Leu Cys Val Asn Cys Gly Tyr His 
                405                 410                 415     


His Asn Ala Asp Tyr Asn Ala Ala Gln Asn Leu Ser Ile Pro Gln Ile 
            420                 425                 430         


Asp Arg Leu Ile Glu Lys Gln Leu Lys Glu Gln Glu Ser Glu Glu Ser 
        435                 440                 445             


Glu Ala Gly Ala Asn Pro Lys 
    450                 455 


<210>  14
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.291449

<400>  14

Met Thr Glu Arg His Asp Asn Glu Ser Ser Lys Ile Lys Ala Glu Val 
1               5                   10                  15      


Ser Leu Leu Asn Ser Ser Val Pro Asp Phe Glu Lys Lys Arg His Val 
            20                  25                  30          


Lys Val Leu Lys Leu His Ile Leu Lys Pro Ala Gly Asp Met Lys Trp 
        35                  40                  45              


Asp Glu Leu Gly Ala Leu Leu Arg Asp Ala Arg Tyr Arg Val Phe Arg 
    50                  55                  60                  


Leu Ala Asn Leu Ala Ile Ser Glu Ala Tyr Leu Asp Phe His Lys Trp 
65                  70                  75                  80  


Arg Ser Gly Gly Asn Glu Gln Pro Lys Leu Lys Ile Ser Gln Leu Asn 
                85                  90                  95      


Arg Asn Leu Arg Ser Met Leu Glu Asp Glu Val Thr Gly Lys Gln Thr 
            100                 105                 110         


Lys Met Ile Lys Ser Asp Arg Tyr Ser Lys Ser Gly Ala Leu Pro Asp 
        115                 120                 125             


Ser Ile Val Ser Pro Leu Ser Met Tyr Lys Leu Gly Gly Leu Thr Ser 
    130                 135                 140                 


Lys Ser Lys Trp Ser Glu Val Leu Arg Gly Lys Ser Ser Leu Pro Thr 
145                 150                 155                 160 


Phe Lys Leu Asn Met Ala Ile Pro Val Arg Cys Asp Lys Pro Gly Asp 
                165                 170                 175     


Arg Arg Ile Glu Arg Thr Lys Asn Gly Asp Ala Glu Val Glu Leu Arg 
            180                 185                 190         


Ile Cys Leu Gln Pro Tyr Pro Arg Val Ile Ile Ala Thr Gly Arg Asn 
        195                 200                 205             


Ser Leu Gly Asp Gly Gln Arg Ala Ile Leu Asp Arg Leu Leu Asp Asn 
    210                 215                 220                 


Thr Lys Tyr Ser Glu Gln Gly Tyr Arg Gln Arg Cys Phe Glu Ile Lys 
225                 230                 235                 240 


Glu Asp Gln Arg Ser Gly Lys Trp His Leu Phe Val Thr Tyr Asp Phe 
                245                 250                 255     


Pro Ala Ile Glu Pro Ala Lys Asn Leu Ser Arg Glu Arg Ile Val Gly 
            260                 265                 270         


Val Asp Leu Gly Ala Ala Cys Pro Leu Tyr Ala Ala Ile Asn Thr Gly 
        275                 280                 285             


His Ala Arg Leu Gly Trp Lys His Phe Ser Pro Leu Ala Ala Arg Val 
    290                 295                 300                 


Arg Ala Leu Gln Asn Gln Thr Ile Arg Arg Arg Arg Gln Ile Leu Arg 
305                 310                 315                 320 


Gly Gly Lys Val Ser Leu Ser Glu Asp Ser Ala Arg Ser Gly His Gly 
                325                 330                 335     


Arg Lys Arg Lys Leu Lys Pro Ile Ser Lys Leu Glu Gly Lys Ile Asp 
            340                 345                 350         


Arg Ala Tyr Thr Thr Leu Asn His Gln Leu Ser Ala Thr Val Ile Lys 
        355                 360                 365             


Phe Ala Lys Asp Asn Gly Ala Gly Val Val Gln Met Glu Asp Leu Lys 
    370                 375                 380                 


Gly Leu Arg Glu Thr Leu Thr Gly Thr Phe Leu Gly Glu Arg Trp Arg 
385                 390                 395                 400 


Tyr Glu Glu Leu Gln Arg Phe Ile Arg Tyr Lys Ala Asp Glu Ala Gly 
                405                 410                 415     


Ile Glu Ile Arg Leu Val Asn Pro Gln Tyr Thr Ser Arg Arg Cys Ser 
            420                 425                 430         


Glu Cys Gly His Ile His Lys Asp Phe Thr Arg Glu Phe Arg Asp Lys 
        435                 440                 445             


Ser Arg Glu Gly Asn Lys Ser Val Arg Phe Leu Cys Pro Asp Cys Gly 
    450                 455                 460                 


Phe Thr Ala Asp Pro Asp Tyr Asn Ala Ala Arg Asn Leu Ala Ser Leu 
465                 470                 475                 480 


Asp Ile Ala Ala Ile Ile Glu Arg Gln Leu Glu Ile Gln Gly Leu Arg 
                485                 490                 495     


Lys His Asp Pro 
            500 


<210>  15
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.297599

<400>  15

Met Lys Glu Lys Ser Lys Thr Leu Val Lys Val Ala Arg Leu Arg Ile 
1               5                   10                  15      


Leu Lys Pro Ala Gly Asp Met Lys Trp Ser Glu Leu Gly Glu Met Leu 
            20                  25                  30          


Arg Thr Val Arg Tyr Arg Val Phe Arg Leu Ala Asn Leu Ala Val Ser 
        35                  40                  45              


Glu Ala Tyr Leu Gly Phe His Met Tyr Arg Thr Asn Arg Ala Thr Glu 
    50                  55                  60                  


Phe Lys Ala Glu Thr Ile Gly Lys Leu Ser Arg Arg Leu Arg Glu Met 
65                  70                  75                  80  


Leu Ile Glu Glu Gly Val Asp Glu Lys Asp Leu Ser Arg Tyr Ser Gln 
                85                  90                  95      


Thr Gly Ala Val Pro Asp Thr Val Ala Gly Ala Leu Gly Gln Tyr Lys 
            100                 105                 110         


Ile Arg Gly Ile Thr Ser Pro Thr Lys Trp Arg Gln Val Val Arg Gly 
        115                 120                 125             


Gln Ala Ala Leu Pro Thr Phe Arg Asn Asp Met Ala Ile Pro Ile Arg 
    130                 135                 140                 


Cys Asp Lys Gln Tyr Gln Arg Arg Leu Glu Lys Thr Glu Ala Gly Glu 
145                 150                 155                 160 


Ile Glu Val Glu Leu Met Ile Cys Arg Lys Pro Tyr Pro Arg Ile Val 
                165                 170                 175     


Leu Gly Thr Ala Asp Leu Gly Pro Gly Gln Arg Ala Ile Leu Glu Arg 
            180                 185                 190         


Leu Leu Gln Asn Thr Asp Asn Ser Ala Asp Gly Tyr Arg Gln Arg Leu 
        195                 200                 205             


Phe Glu Ala Lys Gln Asp Thr Gln Thr Lys Lys Trp Trp Leu Tyr Val 
    210                 215                 220                 


Thr Tyr Asp Phe Pro Arg Leu Lys Glu Gly Lys Leu Asn Gln Glu Ile 
225                 230                 235                 240 


Val Val Gly Val Asp Leu Gly Phe Ser Ile Pro Leu Tyr Val Ala Leu 
                245                 250                 255     


Asn Ile Gly His Ala Arg Leu Gly Arg Arg His Phe Gln Ala Leu Gly 
            260                 265                 270         


Asn Arg Ile Arg Ser Leu Gln Arg Gln Val Leu Ala Arg Arg Arg Ser 
        275                 280                 285             


Ile Gln Arg Gly Gly Arg Val Asn Ile Ser His Ser Thr Ala Arg Ser 
    290                 295                 300                 


Gly His Gly Arg Lys Arg Lys Leu Leu Pro Thr Glu Lys Leu Arg Gly 
305                 310                 315                 320 


Arg Ile Glu Lys Ser Tyr Ser Thr Leu Asn His Gln Leu Ser Ala Ser 
                325                 330                 335     


Val Ile Asp Phe Ala Lys Asn His His Ala Gly Thr Ile Gln Ile Glu 
            340                 345                 350         


Asp Leu Ala Asn Leu Lys Glu Glu Leu Ala Gly Thr Phe Ile Gly Ala 
        355                 360                 365             


Arg Trp Arg Tyr His Gln Leu Gln Gln Phe Leu Lys Tyr Lys Ala Glu 
    370                 375                 380                 


Glu Ala Gly Ile Thr Leu Asn Gln Val Asn Pro Arg Tyr Thr Ser Arg 
385                 390                 395                 400 


Arg Cys Ser Glu Cys Gly Phe Ile Asn Ile Asp Phe Asp Arg Ala Phe 
                405                 410                 415     


Arg Asp Ala Gly Arg Thr Glu Gly Arg Val Thr Lys Phe Leu Cys Pro 
            420                 425                 430         


Glu Cys Gly Tyr Glu Ala Asp Pro Asp Tyr Asn Ala Ala Arg Asn Ile 
        435                 440                 445             


Ser Ile Leu Asp Ile Asp Lys Leu Ile Arg Val Gln Cys Lys Lys Gln 
    450                 455                 460                 


Gly Leu Thr Tyr Asp Ala His 
465                 470     


<210>  16
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.286588

<400>  16

Met Pro Glu Arg Pro Lys Thr Val Asn Lys Val Ile Trp Phe Gln Ile 
1               5                   10                  15      


His Lys Pro Ala Gly Asp Met Thr Trp Lys Glu Leu Gly Asn Leu Leu 
            20                  25                  30          


Arg Glu Ala Arg Tyr Arg Val Phe Arg Leu Ala Asn Leu Ala Val Ser 
        35                  40                  45              


Glu Lys Tyr Leu Ser Phe His Met Trp Arg Thr Gly Gln Glu Tyr Lys 
    50                  55                  60                  


Ser Glu Thr Ile Gly Lys Leu Asn Arg Arg Leu Arg Glu Met Leu Ile 
65                  70                  75                  80  


Glu Glu Gly Val Glu Glu Glu Ser Gln Lys Arg Phe Ser Ala Thr Gly 
                85                  90                  95      


Ala Leu Pro Asp Thr Val Val Ser Thr Leu Ala Lys Gly Lys Leu Ala 
            100                 105                 110         


Ala Ile Thr Ser Lys Ser Lys Trp Lys Asp Val Val Asn Gly Lys Thr 
        115                 120                 125             


Ser Leu Pro Thr Phe Lys Leu Asn Met Ala Ile Pro Val Arg Cys Asp 
    130                 135                 140                 


Lys Ala Glu Gln Arg Arg Leu Arg Arg Thr Glu Ser Gly Asp Val Glu 
145                 150                 155                 160 


Leu Glu Leu Met Ile Cys Lys Gln Pro Tyr Pro Arg Val Val Leu Lys 
                165                 170                 175     


Thr Gly Lys Leu Lys Ser Gly Gln Arg Ala Ile Leu Asp Arg Leu Val 
            180                 185                 190         


Glu Asn Asn Asp Asn Ser Lys Glu Gly Tyr Ser Gln Arg Val Phe Glu 
        195                 200                 205             


Ile Lys Gln Val Glu Asn Asn Asp Gly Ser Lys Glu Trp Arg Leu Tyr 
    210                 215                 220                 


Ile Ser Tyr Thr Phe Pro Lys Lys Ala Val Glu Ala Asn Ala Asp Val 
225                 230                 235                 240 


Ala Val Gly Val Asp Ile Gly Phe Ser Val Pro Leu Val Ala Ala Val 
                245                 250                 255     


Asn Asn Gly Leu Glu Arg Leu Gly Tyr Asn Asp Phe Arg Ala Leu Asn 
            260                 265                 270         


Glu Arg Ile Arg Ser Leu Gln Arg Gln Val Leu Val Arg Arg Arg Ser 
        275                 280                 285             


Met Gln Ser Gly Gly Arg Asp Tyr Val Ser Thr Pro Thr Ala Arg Ser 
    290                 295                 300                 


Gly His Gly Arg Lys Arg Lys Leu Leu Pro Ile Gln Thr Leu Arg Lys 
305                 310                 315                 320 


Arg Trp Asp Asn Ala Tyr Thr Thr Leu Asn His Gln Leu Ser His Ala 
                325                 330                 335     


Val Val Ser Phe Ala Glu Asn His Gly Ala Ala Thr Ile Gln Ile Glu 
            340                 345                 350         


Asn Val Lys Ser Leu Lys Asp Glu Leu Arg Gly Thr Phe Leu Gly Gln 
        355                 360                 365             


Arg Trp Arg Tyr Phe Glu Leu Gln Gln Phe Leu Lys Tyr Lys Ala Asp 
    370                 375                 380                 


Glu Val Gly Ile Glu Leu Arg Glu Val Asn Ala Arg Tyr Thr Ser Arg 
385                 390                 395                 400 


Arg Cys Ser Glu Cys Gly Tyr Ile Asn Met Ala Phe Thr Arg Gln Ala 
                405                 410                 415     


Arg Asp Lys Gly Arg Val Asp Gly Lys Pro Met Glu Phe Val Cys Pro 
            420                 425                 430         


Glu Cys Gly Tyr Lys Ala His Pro Asp Tyr Asn Ala Ala Arg Asn Ile 
        435                 440                 445             


Ala Met Leu Asp Ile Glu Gln Lys Met Gln Val Gln Cys Lys Gln Gln 
    450                 455                 460                 


Gly Ile Thr Tyr Ala Asp Asp Ser Glu Val Leu 
465                 470                 475 


<210>  17
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.286910

<400>  17

Met Thr Trp Pro Glu Leu Gly Asn Met Leu Arg Thr Val Arg Tyr Arg 
1               5                   10                  15      


Val Phe Arg Leu Ala Asn Leu Ala Val Ser Glu Ala Tyr Leu Gly Phe 
            20                  25                  30          


His Met Phe Arg Thr Lys Arg Ala Glu Glu Phe Lys Ala Glu Thr Met 
        35                  40                  45              


Gly Lys Leu Ser Arg Arg Leu Arg Glu Met Leu Ile Glu Glu Gly Val 
    50                  55                  60                  


Asp Glu Lys Asp Leu Ser Arg Tyr Ser Gln Thr Gly Ala Val Pro Asp 
65                  70                  75                  80  


Thr Val Ala Gly Ala Leu Ser Gln Tyr Lys Ile Arg Gly Ile Thr Ser 
                85                  90                  95      


Pro Thr Lys Trp Arg Gln Ile Val Arg Gly Gln Val Ala Leu Pro Thr 
            100                 105                 110         


Phe Arg Asn Thr Met Ser Ile Pro Val Arg Cys Asp Lys Leu Tyr Gln 
        115                 120                 125             


Arg Arg Leu Glu Gln Gly Asp Ser Gly Glu Val Glu Val Glu Leu Met 
    130                 135                 140                 


Ile Cys Arg Asn Pro Tyr Pro Arg Val Val Leu Gly Thr Gly Asp Leu 
145                 150                 155                 160 


Asn Pro Gly Gln Gln Ala Ile Leu Glu Arg Leu Leu Gln Asn Thr Asp 
                165                 170                 175     


Asn Ser Ala Asp Gly Tyr Arg Gln Arg Leu Phe Glu Ile Lys Glu Asp 
            180                 185                 190         


Val Gln Thr Arg Lys Trp Trp Leu Tyr Val Thr Tyr Asp Phe Pro Lys 
        195                 200                 205             


Thr Thr Gly Lys Leu Asn Pro Glu Ile Val Val Gly Val Asp Leu Gly 
    210                 215                 220                 


Phe Ser Ile Pro Leu Tyr Val Ala Leu Asn Ser Gly His Ala Arg Leu 
225                 230                 235                 240 


Gly Tyr Leu His Phe Lys Ala Leu Gly Glu Arg Ile Lys Ser Leu Gln 
                245                 250                 255     


Lys Gln Val Met Ala Arg Arg Arg Ala Ile Gln Arg Gly Gly Arg Val 
            260                 265                 270         


Ser Ile Ser His Ser Thr Ala Arg Thr Gly His Gly Val Lys Arg Lys 
        275                 280                 285             


Leu Gln Pro Thr Glu Lys Leu Arg Gly Arg Ile Glu Lys Ser Tyr Ser 
    290                 295                 300                 


Thr Leu Asn His Gln Leu Ser Ala Ser Val Ile Asp Phe Ala Lys Asn 
305                 310                 315                 320 


His His Ala Gly Val Ile Gln Ile Glu Asp Leu Ser Gly Leu Lys Glu 
                325                 330                 335     


Gln Leu Thr Gly Thr Phe Ile Gly Ala Arg Trp Arg Tyr His Gln Leu 
            340                 345                 350         


Gln Gln Phe Leu Lys Tyr Lys Ala Glu Glu Ala Gly Ile Thr Leu Lys 
        355                 360                 365             


Gln Ile Asn Pro Arg Tyr Thr Ser Arg Arg Cys Ser Glu Cys Gly Phe 
    370                 375                 380                 


Ile Asn Met Asp Phe Asp Arg Ala Phe Arg Asp Ala Gly Arg Thr Tyr 
385                 390                 395                 400 


Gly Lys Val Thr Lys Phe Leu Cys Pro Glu Cys Gly Tyr Glu Ala Asp 
                405                 410                 415     


Pro Asp Tyr Asn Ala Ala Arg Asn Ile Ala Thr Leu Asp Ile Glu Lys 
            420                 425                 430         


Leu Ile Arg Val Gln Cys Glu Lys His Gly Leu Lys Phe Asp Ala His 
        435                 440                 445             


<210>  18
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.292335

<400>  18

Val Gly Lys Glu Gly Lys Arg Asn Val Lys Val Met Lys Ile Arg Ile 
1               5                   10                  15      


Leu Lys Pro Cys Asp Gly Met Thr Trp Asn Glu Leu Gly Gln Leu Leu 
            20                  25                  30          


Arg Asp Ala Arg Tyr Arg Val Phe Arg Leu Ala Asn Leu Thr Val Ser 
        35                  40                  45              


Glu Ala Tyr Leu Asn Phe His Leu Trp Arg Thr Gly Arg Ser Gln Glu 
    50                  55                  60                  


Phe Lys Lys Gln Thr Ile Gly Gln Leu Asn Arg Gln Leu Arg Asn Ile 
65                  70                  75                  80  


Leu Gln Gln Glu Lys Tyr Asp Asp Glu Lys Leu Asn Arg Tyr Ser Lys 
                85                  90                  95      


Thr Gly Ala Leu Pro Asp Thr Val Cys Ser Ala Leu Trp Gln Tyr Lys 
            100                 105                 110         


Leu Met Ala Val Met Lys Lys Ser Lys Trp Ser Glu Val Ile Arg Gly 
        115                 120                 125             


Lys Ser Ser Leu Pro Thr Phe Arg Asn Asp Met Ala Ile Pro Val Arg 
    130                 135                 140                 


Cys Asp Lys Pro Glu Gln Lys Arg Ile Glu Lys Thr Glu Gln Gly Gln 
145                 150                 155                 160 


Val Glu Ala Ala Leu Gln Val Cys Val Gln Pro Tyr Pro Arg Val Ile 
                165                 170                 175     


Leu Gly Thr His Thr Leu Gly Asp Gly Gln Asp Ala Ile Leu Lys Arg 
            180                 185                 190         


Leu Leu Asp Asn Gln Asn Gln Ala Ile Gly Gly Tyr Arg Gln Arg Ser 
        195                 200                 205             


Phe Glu Ile Lys Tyr Asp Glu Gln Lys Arg Trp Trp Leu Phe Ile Thr 
    210                 215                 220                 


Tyr Asp Phe Pro Ala Thr Glu Val Ala Thr Asp Lys Thr Ile Ala Val 
225                 230                 235                 240 


Gly Val Asp Leu Gly Val Ser Val Pro Leu Tyr Ala Ala Val Asn Asn 
                245                 250                 255     


Gly Pro Ala Arg Leu Gly Arg Arg Glu Phe Gly Gly Leu Gly Arg Arg 
            260                 265                 270         


Ile Arg Asp Leu Arg Asn Gln Thr Asp Ala Arg Arg Arg Ser Ile Gln 
        275                 280                 285             


Arg Ser Gly Arg Glu Gly Gln Ser Asp Asp Thr Ala Arg Ala Gly His 
    290                 295                 300                 


Gly Arg Lys Arg Lys Leu Leu Pro Ile His Ile Leu Glu Gly Arg Leu 
305                 310                 315                 320 


Asp Lys Ala Tyr Thr Thr Leu Asn His Gln Met Ser Ala Ala Val Ile 
                325                 330                 335     


Lys Phe Ala Ala Glu Gln Gly Ala Gly Ile Ile Gln Ile Glu Asn Leu 
            340                 345                 350         


Ala Gly Leu Gln Asp Glu Leu Arg Gly Thr Phe Ile Gly Gly Arg Trp 
        355                 360                 365             


Arg Tyr Arg Gln Leu Gln Asp Phe Leu Lys Tyr Lys Thr Gln Glu Met 
    370                 375                 380                 


Gly Ile Glu Leu Arg Gln Val Asn Pro Lys Tyr Thr Ser Arg Arg Cys 
385                 390                 395                 400 


Ser Lys Cys Gly Phe Ile His Lys Asp Phe Asp Arg Asp Tyr Arg Asn 
                405                 410                 415     


Arg His Ser Glu Asn Gly Lys Pro Ala Gln Phe Val Cys Pro Asn Pro 
            420                 425                 430         


Asp Cys Lys Tyr Glu Ser Asp Pro Asp Tyr Asn Ala Ala Arg Asn Leu 
        435                 440                 445             


Ala Thr Leu Asp Ile Glu Glu Gln Ile Arg Val Gln Cys Gln Lys Gln 
    450                 455                 460                 


Gly Leu Glu Tyr Asp Ser Lys Lys Asp Lys Asn Ala Leu 
465                 470                 475         


<210>  19
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.293576

<400>  19

Met Lys Glu Lys Ser Lys Thr Leu Val Lys Val Ala Arg Leu Arg Ile 
1               5                   10                  15      


Leu Lys Pro Ala Gly Asp Met Thr Trp Ser Glu Leu Gly Glu Met Leu 
            20                  25                  30          


Arg Thr Val Arg Tyr Arg Val Phe Arg Leu Ala Asn Leu Ala Val Ser 
        35                  40                  45              


Glu Ala Tyr Leu Gly Phe His Met Phe Arg Thr Gln Arg Ala Ala Glu 
    50                  55                  60                  


Phe Lys Ala Glu Thr Met Gly Lys Leu Ser Arg Arg Leu Arg Glu Met 
65                  70                  75                  80  


Leu Ile Glu Glu Gly Val Asp Glu Lys Glu Leu Asn Cys Tyr Ser Leu 
                85                  90                  95      


Thr Gly Ala Val Pro Asp Thr Val Ala Gly Ala Leu His Gln Tyr Lys 
            100                 105                 110         


Ile Arg Gly Ile Thr Ser Pro Thr Lys Trp Arg Gln Val Val Arg Gly 
        115                 120                 125             


Gln Ala Ala Leu Pro Thr Phe Arg Asn Asp Met Ser Ile Pro Ile Arg 
    130                 135                 140                 


Cys Asp Lys Pro Tyr Gln Arg Arg Leu Glu Lys Thr Glu Ala Gly Glu 
145                 150                 155                 160 


Val Glu Val Glu Leu Met Ile Cys Arg Lys Pro Tyr Pro Arg Ile Val 
                165                 170                 175     


Leu Gly Thr Ala Asp Val Gly Pro Gly Gln Glu Val Ile Leu Glu Arg 
            180                 185                 190         


Leu Leu Gln Asn Lys Asp Asn Ser Ser Asp Gly Tyr Arg Gln Arg Leu 
        195                 200                 205             


Phe Glu Ala Lys Gln Asp Arg Gln Thr Gly Lys Trp Trp Leu Tyr Val 
    210                 215                 220                 


Thr Tyr Asp Phe Pro Arg Pro Glu Glu Gly Glu Leu Asn Pro Glu Ile 
225                 230                 235                 240 


Val Val Gly Val Asp Leu Gly Phe Ser Val Pro Leu Tyr Val Ala Ile 
                245                 250                 255     


Asn Asn Gly Tyr Ala Arg Leu Gly Arg Arg His Phe Gln Ala Leu Gly 
            260                 265                 270         


Asn Arg Ile Arg Ser Leu Gln Arg Gln Val Leu Ala Arg Arg Arg Ser 
        275                 280                 285             


Ile Gln Arg Gly Gly Arg Val Asn Ile Ser His Asp Thr Ala Arg Ser 
    290                 295                 300                 


Gly His Gly Ile Lys Arg Lys Leu Leu Pro Thr Glu Lys Leu Arg Gly 
305                 310                 315                 320 


Arg Ile Glu Lys Ser Tyr Ser Thr Leu Asn His Gln Leu Ser Ala Ser 
                325                 330                 335     


Val Ile Asp Phe Thr Lys Asn His His Ala Gly Thr Ile Gln Ile Glu 
            340                 345                 350         


Asp Leu Ala Asn Leu Lys Glu Val Leu Ala Gly Thr Phe Ile Gly Ala 
        355                 360                 365             


Arg Trp Arg Tyr His Gln Leu Gln Gln Phe Leu Lys Tyr Lys Ala Asp 
    370                 375                 380                 


Glu Ala Gly Ile Thr Leu Lys Glu Val Asn Pro Arg Tyr Thr Ser Arg 
385                 390                 395                 400 


Arg Cys Ser Glu Cys Gly Phe Ile His Lys Asp Phe Asp Arg Ala Phe 
                405                 410                 415     


Arg Asp Ser Gly Arg Thr Asp Gly Lys Val Ala Arg Phe Val Cys Pro 
            420                 425                 430         


Glu Cys Gly Tyr Gly Pro Val Asp Pro Asp Tyr Asn Ala Ala Lys Asn 
        435                 440                 445             


Ile Ser Thr Leu Asp Ile Glu Lys His Ile Arg Val Gln Cys Lys Lys 
    450                 455                 460                 


Gln Gly Leu Glu Tyr Glu Val His 
465                 470         


<210>  20
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.294537

<400>  20

Met Lys Glu Lys Ala Lys Thr Leu Val Lys Val Ala Arg Leu Arg Ile 
1               5                   10                  15      


Leu Lys Pro Ala Gly Asp Met Thr Trp Pro Glu Leu Gly Asn Met Leu 
            20                  25                  30          


Arg Thr Val Arg Tyr Arg Val Phe Arg Leu Ala Asn Leu Ala Val Ser 
        35                  40                  45              


Glu Ala Tyr Leu Gly Phe His Met Phe Arg Thr Lys Arg Ala Glu Glu 
    50                  55                  60                  


Phe Lys Ala Glu Thr Met Gly Lys Leu Ser Arg Arg Leu Arg Glu Met 
65                  70                  75                  80  


Leu Ile Glu Glu Gly Val Asp Glu Lys Asp Leu Ser Arg Tyr Ser Gln 
                85                  90                  95      


Thr Gly Ala Val Pro Asp Thr Val Ala Gly Ala Leu Ser Gln Tyr Lys 
            100                 105                 110         


Ile Arg Gly Ile Thr Ser Pro Thr Lys Trp Arg Gln Ile Val Arg Gly 
        115                 120                 125             


Gln Val Ala Leu Pro Thr Phe Arg Asn Thr Met Ser Ile Pro Val Arg 
    130                 135                 140                 


Cys Asp Lys Leu Tyr Gln Arg Arg Leu Glu Gln Gly Asp Ser Gly Glu 
145                 150                 155                 160 


Val Glu Val Glu Leu Met Ile Cys Arg Asn Pro Tyr Pro Arg Val Val 
                165                 170                 175     


Leu Gly Thr Gly Asp Leu Asn Pro Gly Gln Gln Ala Ile Leu Glu Arg 
            180                 185                 190         


Leu Leu Gln Asn Thr Asp Asn Ser Ala Asp Gly Tyr Arg Gln Arg Leu 
        195                 200                 205             


Phe Glu Ile Lys Glu Asp Val Gln Thr Arg Lys Trp Trp Leu Tyr Val 
    210                 215                 220                 


Thr Tyr Asp Phe Pro Lys Thr Thr Gly Lys Leu Asn Pro Glu Ile Val 
225                 230                 235                 240 


Val Gly Val Asp Leu Gly Phe Ser Ile Pro Leu Tyr Val Ala Leu Asn 
                245                 250                 255     


Ser Gly His Ala Arg Leu Gly Tyr Leu His Phe Lys Ala Leu Gly Glu 
            260                 265                 270         


Arg Ile Lys Ser Leu Gln Lys Gln Val Met Ala Arg Arg Arg Ala Ile 
        275                 280                 285             


Gln Arg Gly Gly Arg Val Ser Ile Ser His Ser Thr Ala Arg Thr Gly 
    290                 295                 300                 


His Gly Val Lys Arg Lys Leu Gln Pro Thr Glu Lys Leu Arg Gly Arg 
305                 310                 315                 320 


Ile Glu Lys Ser Tyr Ser Thr Leu Asn His Gln Leu Ser Ala Ser Val 
                325                 330                 335     


Ile Asp Phe Ala Lys Asn His His Ala Gly Val Ile Gln Ile Glu Asp 
            340                 345                 350         


Leu Ser Gly Leu Lys Glu Gln Leu Thr Gly Thr Phe Ile Gly Ala Arg 
        355                 360                 365             


Trp Arg Tyr His Gln Leu Gln Gln Phe Leu Lys Tyr Lys Ala Glu Glu 
    370                 375                 380                 


Ala Gly Ile Thr Leu Lys Gln Ile Asn Pro Arg Tyr Thr Ser Arg Arg 
385                 390                 395                 400 


Cys Ser Glu Cys Gly Phe Ile Asn Met Asp Phe Asp Arg Ala Phe Arg 
                405                 410                 415     


Asp Ala Gly Arg Thr Tyr Gly Lys Val Thr Lys Phe Leu Cys Pro Glu 
            420                 425                 430         


Cys Gly Tyr Glu Ala Asp Pro Asp Tyr Asn Ala Ala Arg Asn Ile Ala 
        435                 440                 445             


Thr Leu Asp Ile Glu Lys Leu Ile Arg Val Gln Cys Glu Lys His Gly 
    450                 455                 460                 


Leu Lys Phe Asp Ala His 
465                 470 


<210>  21
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.298538

<400>  21

Met Ala Lys Lys Ala Lys Thr Met Phe Lys Val Thr Asn Phe Arg Ile 
1               5                   10                  15      


Leu Lys Pro Ala Gly Asp Met Thr Trp Lys Glu Leu Gly Gln Leu Leu 
            20                  25                  30          


Arg Asp Ala Arg Tyr Arg Thr Phe Arg Met Ala Asn Leu Ala Leu Ser 
        35                  40                  45              


Glu Ala Tyr Leu Asn Phe Tyr Leu Leu Lys Lys Gly Asp Leu Lys Glu 
    50                  55                  60                  


Tyr Lys Asn Val Lys Ile Gly Gln Ile Ala Lys Arg Leu Arg Asp Met 
65                  70                  75                  80  


Leu Ile Glu Glu Gly Val Asp Glu Glu Val Gln Asn Arg Phe Ser Pro 
                85                  90                  95      


Lys Val Ala Leu Pro Ala Tyr Val Tyr Ser Ala Leu Asp Gln Phe Lys 
            100                 105                 110         


Leu Arg Gly Leu Thr Ser Lys Ser Asn Trp Lys Lys Val Leu Arg Gly 
        115                 120                 125             


Gln Ala Ser Leu Pro Thr Phe Arg Leu Asn Met Ser Val Pro Ile Arg 
    130                 135                 140                 


Cys Asp Lys Pro Glu His Arg Arg Leu Glu Lys Thr Glu Asn Gly Asn 
145                 150                 155                 160 


Val Glu Val Asp Leu Met Ile Cys Arg Lys Pro Tyr Pro Arg Val Val 
                165                 170                 175     


Leu Glu Thr Leu Lys Leu Asp Gly Ser Ser Lys Ala Ile Leu Asp Arg 
            180                 185                 190         


Leu Leu Glu Asn Glu Asp Asn Ser Pro Gly Asn Tyr Arg Gln Arg Cys 
        195                 200                 205             


Phe Glu Val Lys Gln Asn Pro Arg Ser Asn Asp Trp Trp Leu Tyr Val 
    210                 215                 220                 


Thr Tyr Glu Met Pro Val Asp Lys Asp Lys Lys Leu Asp Pro Lys Val 
225                 230                 235                 240 


Ile Val Gly Val Asp Leu Gly Phe Ser Val Pro Leu Tyr Val Ala Ile 
                245                 250                 255     


Asn Asn Gly His Ala Arg Leu Gly Arg Arg His Phe Gln Ala Leu Gly 
            260                 265                 270         


Lys Arg Ile His Asn Leu Gln Asn Gln Val Leu Ala Arg Arg Arg Ser 
        275                 280                 285             


Ile Gln Arg Gly Gly Gln Val Asn Leu Ser His Ser Thr Ser Arg Ser 
    290                 295                 300                 


Gly His Gly Arg Lys Arg Lys Leu Gln Pro Thr Glu Lys Leu Gln Gln 
305                 310                 315                 320 


Lys Ile Asn Ser Ala Tyr Ser Thr Leu Asn His Gln Leu Ser Ser Ser 
                325                 330                 335     


Val Ile Asp Phe Ala Asn Asn His Lys Ala Gly Thr Ile Gln Ile Glu 
            340                 345                 350         


Asp Leu Glu Thr Leu Lys Glu Gln Leu Thr Gly Thr Tyr Ile Gly Arg 
        355                 360                 365             


Gln Trp Arg Tyr Tyr Gln Leu Gln Gln Phe Ile Glu Tyr Lys Ala Lys 
    370                 375                 380                 


Glu Asn Ser Ile Thr Val Lys Lys Ile Asn Pro Lys Tyr Thr Ser Arg 
385                 390                 395                 400 


Arg Cys Ser Met Cys Gly His Ile His Ala Asp Phe Asp Arg Thr Phe 
                405                 410                 415     


Arg Asp Arg Ser Ser Asn Lys Gly Phe Val Thr Lys Phe Ile Cys Pro 
            420                 425                 430         


Glu Cys Asn Phe Glu Ala Asp Pro Asp Tyr Asn Ala Ala Lys Asn Ile 
        435                 440                 445             


Ser Thr Leu Asp Ile Glu Asn Lys Ile Lys Leu Gln Cys Lys Lys Gln 
    450                 455                 460                 


Lys Ile Asp Tyr 
465             


<210>  22
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.19924

<400>  22

Met Pro Lys Ile Thr Arg Lys Ile Glu Leu Leu Phe Asp Arg Ser Gly 
1               5                   10                  15      


Leu Ser Glu Glu Glu Cys Lys Glu Lys Trp Arg Phe Ile Tyr Gln Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Val Ala Asn Arg Leu Val Asn Gln Leu Tyr 
        35                  40                  45              


Leu Ala Asp Glu Ile Asp Asp Ile Leu Arg Leu Ser Asp Gln Glu Tyr 
    50                  55                  60                  


Ile Ala Leu Arg Lys Lys Leu Ala Asn Lys Lys Leu Asp Glu Ala Thr 
65                  70                  75                  80  


Arg Ile Ser Leu Glu Glu Gln Met Ser Gln Val Met Lys Arg Val Asn 
                85                  90                  95      


Glu Arg Arg Ser Ala Ile Leu Gln Arg Pro Gln Gln Ser Phe Ala Tyr 
            100                 105                 110         


Ser Val Val Thr Asp Ser Asp Thr Glu Gly Leu Thr Ala Lys Ile Leu 
        115                 120                 125             


Asp Val Leu Lys Gln Asp Val Leu Ser His Tyr Lys Ala Asp Thr Lys 
    130                 135                 140                 


Glu Val Leu Lys Gly Glu Lys Ser Ile Ser Asn Tyr Lys Lys Gly Met 
145                 150                 155                 160 


Pro Ile Pro Phe Ala Phe Asn Asp Ser Leu Arg Leu Tyr Lys Glu Asp 
                165                 170                 175     


Gly Phe Phe Tyr Leu Lys Trp Tyr Asn Gly Ile Arg Phe Leu Leu Asn 
            180                 185                 190         


Phe Gly Arg Asp Ala Ser Asn Asn Gln Leu Ile Val Glu Arg Cys Leu 
        195                 200                 205             


Gly Ile Ser Lys Asp Glu Ile Ser Tyr Lys Ala Cys Ser Ser Ser Ile 
    210                 215                 220                 


Gln Ile Lys Lys Lys Gly Asn His Ser Lys Ile Phe Leu Leu Leu Val 
225                 230                 235                 240 


Val Asp Val Pro Val Glu Gln Tyr Ala Gln Lys Pro Asn Met Val Val 
                245                 250                 255     


Gly Val Asp Leu Gly Leu Asn Val Pro Ile Tyr Ala Ala Ser Asn Ser 
            260                 265                 270         


Thr Leu Glu Arg Lys Ala Ile Gly Ser Arg Glu Ala Phe Leu Asn Gln 
        275                 280                 285             


Arg Gly Ala Phe Gln Arg Arg Phe Arg Ala Leu Gln Arg Leu Gln Thr 
    290                 295                 300                 


Thr Lys Gly Gly Arg Gly Arg Leu His Lys Leu Glu Pro Leu Glu Arg 
305                 310                 315                 320 


Val Arg Glu Ala Glu Arg Asn Trp Val Arg Thr Gln Asn His Leu Phe 
                325                 330                 335     


Ser Arg Glu Val Ile Asn Phe Ala Ile Asp Val Gly Ala Ser Thr Ile 
            340                 345                 350         


Gln Met Glu Lys Leu Ala Asn Phe Gly Arg Asp Ala Gln Gly Glu Val 
        355                 360                 365             


Arg Glu Asp Lys Lys Tyr Val Leu Arg Asn Trp Ser Tyr Phe Glu Leu 
    370                 375                 380                 


Gln Asn Leu Ile Glu Tyr Lys Ala Lys Arg Ala Gly Ile Lys Val Lys 
385                 390                 395                 400 


Tyr Ile Asn Pro Ala Phe Thr Ser Gln Thr Cys Ser Glu Cys Gly Gln 
                405                 410                 415     


Leu Gly Glu Arg Asp Ser Ile His Phe Lys Cys Thr Asn Pro Asp Cys 
            420                 425                 430         


Pro Asn Cys Gly Lys Asp Ile His Ala Asp Tyr Asn Gly Ala Arg Asn 
        435                 440                 445             


Ile Ala Lys Ser Lys Asp Tyr Ile Lys 
    450                 455         


<210>  23
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  23

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  24
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.274559

<400>  24

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Asp Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Lys Lys Lys Val Ala Ala Thr Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ser Thr Glu Phe Glu Thr 
        115                 120                 125             


Lys Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Lys Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Thr Asp Ser 
                165                 170                 175     


Leu Arg Ile Lys Lys Asp Asn Lys Asp Phe Tyr Leu Leu Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Val Lys Leu Phe Leu Leu Leu Val Val Ser Ile Pro Lys Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Ser Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr Gly Gly Lys Gly Arg Thr 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Thr His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ser Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln His Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Ala Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Glu Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  25
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  25

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Gln Glu Arg Lys Asp Gln Trp Asn Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Gly Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Arg Ala Leu Glu Lys Ala Lys Lys Gln Lys Ala Pro 
65                  70                  75                  80  


Asp Glu Glu Val Ile Ala Glu Leu Ser Gln Gln Val Ala Thr Ala Glu 
                85                  90                  95      


Gln Glu Met Asp Glu Gln Ala Lys Ala Ile Cys Gln Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Thr Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Gly Gln Ile Leu Thr Cys Leu Arg Gln Gly Val Phe Ser 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ser Ile 
145                 150                 155                 160 


Arg Thr Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asp Ser 
                165                 170                 175     


Leu Arg Ile Gly Phe Glu Asp Gly Glu Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Arg Phe Asp Phe Gly Lys Asp Arg Ser Asn Asn Cys 
        195                 200                 205             


Leu Ile Val Gln Arg Cys Met Lys Met Asp Lys Asp Tyr Glu Gly Asp 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Met Val Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Pro Lys Phe Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu Arg Val 
                245                 250                 255     


Glu Leu Asn Lys Asn Ile Val Val Gly Val Asp Leu Gly Ile Asn Ala 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Thr Thr Pro Glu Arg Lys Gln Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Glu Arg Met Ala Phe Gln Arg Arg Phe 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr Gly Gly Arg Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu Gln Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Ile Asp Phe Ala 
            340                 345                 350         


Val Lys Ala Arg Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Thr Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly His Gln Gly Phe Arg Glu Gly Ile Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys Phe Gly Glu Lys Glu His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Glu Ile Ile 
    450                 455                 460                 


Lys Asn Asn Glu Glu 
465                 


<210>  26
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.288480

<400>  26

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Thr Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Arg Glu Leu Ala Arg Ala Glu Lys Gln Lys Lys Pro 
65                  70                  75                  80  


Asp Val Asp Ala Ile Ala Glu Leu Arg Glu Lys Val Thr Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Ser Asp Gln Glu Arg Ala Ile Cys Thr Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Ile Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Val Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Val Lys Leu Phe Leu Leu Leu Val Val Ser Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Thr 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Arg Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  27
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.288668

<400>  27

Met Pro Thr Met Thr Arg Lys Ile Glu Leu Lys Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Glu Glu Arg Lys Ala Gln Leu Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Asn Glu Phe Glu Lys Ala Lys Lys Lys Gly Asp Glu 
65                  70                  75                  80  


Glu Gln Ile Val Glu Leu Ser Leu Arg Val Ala Ala Ala Glu Lys Glu 
                85                  90                  95      


Leu Thr Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu Met Ser 
            100                 105                 110         


Thr Asp Thr Leu Ala Tyr Arg Phe Ala Asn Glu Ile Glu Ile Asn Val 
        115                 120                 125             


Phe Gly Gln Ile Leu Ala Cys Leu Lys Gln Gly Ile His Ser Thr Phe 
    130                 135                 140                 


Lys Lys Asp Ala Ala Asp Val Lys Arg Gly Glu Arg Ala Ile Arg Asn 
145                 150                 155                 160 


Phe Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Ser Lys Ser Ile Arg 
                165                 170                 175     


Ile Glu Asn Glu Gly Ser Asp Phe Tyr Leu Arg Trp Tyr Asn Gly Leu 
            180                 185                 190         


Arg Phe Arg Phe Asp Phe Gly Lys Asp Arg Ser Asn Asn Arg Leu Ile 
        195                 200                 205             


Val Ser Arg Cys Leu Asn Leu Asp Pro Asp Phe Glu Asp Glu Tyr Lys 
    210                 215                 220                 


Leu Ser Asn Ser Ser Leu Gln Met Val Lys Arg Asp Gly Arg Pro Lys 
225                 230                 235                 240 


Leu Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu Asn Val Glu Leu 
                245                 250                 255     


Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Ile Asn Ser Pro Ala 
            260                 265                 270         


Tyr Val Ala Thr Asn Ile Thr Met Glu Arg Gln Arg Ile Gly Ser Arg 
        275                 280                 285             


Asp Thr Phe Leu Asn Ala Arg Met Ala Ile Gln Arg Arg Phe Gln Ser 
    290                 295                 300                 


Leu Gln Lys Leu Gln Asn Thr Ala Gly Gly Arg Gly Arg Lys Lys Lys 
305                 310                 315                 320 


Leu Glu Pro Leu Glu Arg Leu Lys Glu Thr Glu Arg Asn Trp Val Arg 
                325                 330                 335     


Thr Gln Asn His Leu Phe Ser Arg Asp Val Val Gln Phe Ala Val Lys 
            340                 345                 350         


Thr Arg Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe Gly Lys 
        355                 360                 365             


Asp Asp Asp Gly Asn Ala Asp Glu Lys Lys Glu Phe Val Leu Arg Asn 
    370                 375                 380                 


Trp Ser Tyr Tyr Glu Leu Gln Thr Met Ile Lys Tyr Lys Ala Ala Lys 
385                 390                 395                 400 


Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser Arg Thr 
                405                 410                 415     


Cys Ser Trp Cys Gly His Glu Gly Asp Arg Lys Gly Glu Thr Phe Ile 
            420                 425                 430         


Cys Glu Asn Pro Glu Cys Glu Lys Tyr Gly Lys Lys Glu Asn Ala Asp 
        435                 440                 445             


Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Thr Asp Ile Ile Lys 
    450                 455                 460             


<210>  28
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.289206

<400>  28

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Gln Thr Pro 
65                  70                  75                  80  


Asp Glu Gly Leu Ile Ala Glu Leu Ser Arg Lys Leu Ser Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Ala Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Thr Leu Ser Tyr Asn Phe Ala Lys Glu Ile Glu Thr 
        115                 120                 125             


Asn Ile Phe Gly Gln Ile Leu Thr Cys Leu Arg Gln Gly Val Tyr Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Lys Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asn Ser 
                165                 170                 175     


Leu Lys Ile Glu Ser Asp Ser Gly Glu Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Leu Thr Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Met Ile Val Asn Arg Cys Met Lys Met Asp Glu Asp Phe Glu Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Leu Ala Lys Arg Asp Gly Lys 
225                 230                 235                 240 


Pro Lys Leu Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu His Val 
                245                 250                 255     


Lys Leu Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Val Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Thr Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Thr 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Asp Ala Glu Arg Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asn Phe Ala 
            340                 345                 350         


Val Gln Ala Arg Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Lys Asp Gly Asn Ala Asp Glu Lys Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Phe Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ser 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Val Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Gln Gly Asp Arg Lys Ser Thr Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Lys Cys Lys His Tyr Gly Glu Ser Ile His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Asn Asp Ile Val 
    450                 455                 460                 


Lys Glu Asn Glu 
465             


<210>  29
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.290598

<400>  29

Met Pro Lys Ile Thr Arg Lys Ile Glu Met Thr Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Thr Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Met Lys His Ala Asp Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Lys Ala Glu Lys Lys Ser Pro Asp 
65                  70                  75                  80  


Glu Asp Leu Ile Ala Glu Leu Arg Glu Lys Leu Ala Ala Ala Glu Gln 
                85                  90                  95      


Glu Met Thr Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu Met 
            100                 105                 110         


Ser Thr Gln Thr Leu Ala Tyr Lys Phe Ala Thr Glu Ile Glu Ile Asn 
        115                 120                 125             


Val Phe Gly Gln Ile Leu Ala Cys Leu Lys Gln Ala Ala Gln Ser Asn 
    130                 135                 140                 


Phe Lys Ser Asp Ala Lys Asp Val Lys Arg Gly Glu Arg Ala Ile Arg 
145                 150                 155                 160 


Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asp Asn Ile 
                165                 170                 175     


Arg Ile Asp Ala Asp Gly Asp Glu Phe Tyr Leu Arg Trp Tyr Asn Gly 
            180                 185                 190         


Leu Arg Phe His Leu Thr Phe Gly Lys Asp Lys Ser Asn Asn Arg Met 
        195                 200                 205             


Ile Val Lys Arg Cys Leu Lys Met Asp Lys Asp Phe Glu Gly Glu Tyr 
    210                 215                 220                 


Lys Leu Cys Asn Ser Ser Ile Gln Met Val Lys Arg Asp Gly Lys Pro 
225                 230                 235                 240 


Lys Leu Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu His Val Glu 
                245                 250                 255     


Leu Asn Lys Asn Val Val Val Gly Val Asp Leu Gly Val Asn Val Pro 
            260                 265                 270         


Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly Glu 
        275                 280                 285             


Arg Glu His Phe Leu Asn Thr Arg Met Gln Ile Gln Arg Arg Tyr Lys 
    290                 295                 300                 


Ser Leu Gln Arg Leu Lys Ala Thr Ala Gly Gly Lys Gly Arg Thr Lys 
305                 310                 315                 320 


Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp Val 
                325                 330                 335     


His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asn Phe Ala Val 
            340                 345                 350         


Gln Thr His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe Gly 
        355                 360                 365             


Lys Asp Asp Asp Gly Asn Ala Asp Glu Gln Lys Glu Phe Val Leu Arg 
    370                 375                 380                 


Asn Trp Ser Phe Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala Ala 
385                 390                 395                 400 


Lys Tyr Gly Ile Lys Val Glu Lys Val Lys Pro Ala Tyr Thr Ser Lys 
                405                 410                 415     


Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Gln Gly Val Thr Phe 
            420                 425                 430         


Ile Cys Glu Asn Pro Ala Cys Lys Gln Cys Gly Glu Lys Val His Ala 
        435                 440                 445             


Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile Lys 
    450                 455                 460                 


Lys Asn Glu 
465         


<210>  30
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.290816

<400>  30

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu His Leu Cys Thr Asp Gly 
1               5                   10                  15      


Leu Thr Asp Glu Gln Gln Lys Ala Gln Arg Leu Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Val Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Leu Lys His Asp Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Ser Arg Glu Leu Ala Arg Ala Glu Lys Lys His Asp Asp 
65                  70                  75                  80  


Glu Leu Thr Thr Glu Leu Arg Gly Lys Leu Ala Ala Ala Glu Arg Glu 
                85                  90                  95      


Met Thr Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu Met Ser 
            100                 105                 110         


Thr Gln Ser Leu Ser Tyr Arg Leu Val Thr Glu Leu Glu Thr Lys Ile 
        115                 120                 125             


Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Tyr Ala Thr Phe 
    130                 135                 140                 


Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile Arg Asn 
145                 150                 155                 160 


Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asn Asp Ser Val Arg 
                165                 170                 175     


Ile Glu Tyr Asp Glu Lys Glu Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Asp Ile Arg Phe Lys Phe His Phe Gly Arg Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Ser Arg Cys Leu Lys Leu Asp Lys Asp Tyr Glu Gly Asp 
    210                 215                 220                 


Tyr Gln Leu Cys Asn Ser Ser Ile Gln Ile Val Lys Arg Asp Gly Ser 
225                 230                 235                 240 


Thr Lys Phe Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Arg Ile Val Val Gly Val Asp Leu Gly Ile Asn Tyr 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Cys Thr Glu Glu Arg Met Tyr Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Thr Arg Met Gln Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Lys Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Ser 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Asn Ala Glu Arg Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Leu Lys Val Val Asn Phe Ala 
            340                 345                 350         


Val Gln Thr His Ala Ala Thr Ile His Leu Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asp Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Ser Met Ile Glu Tyr Lys Ala 
385                 390                 395                 400 


Lys Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Gln Thr Cys Ser Trp Cys Gly Gln Arg Gly Phe Arg Gln Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys Cys Gly Glu Lys Glu Asn 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Val Ile 
    450                 455                 460                 


Lys Asp Lys Asn Glu 
465                 


<210>  31
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.295071

<400>  31

Thr Pro Phe Val Leu Tyr Phe Gln Asn Tyr Ser Leu Ser Leu Arg Gln 
1               5                   10                  15      


His Ile Thr Leu Tyr Ser Met Pro Thr Ile Thr Arg Lys Ile Glu Leu 
            20                  25                  30          


Thr Leu Cys Thr Glu Gly Leu Ser Asp Gln Glu Arg Lys Asp Gln Trp 
        35                  40                  45              


Asn Leu Leu Tyr His Ile Asn Asp Asn Leu Tyr Arg Ala Ala Asn Asn 
    50                  55                  60                  


Ile Ser Ser Lys Leu Tyr Leu Asp Asp His Val Gly Ser Met Val Arg 
65                  70                  75                  80  


Leu Lys His Ala Glu Tyr Leu Ser Leu Leu Arg Ala Met Glu Lys Ala 
                85                  90                  95      


Lys Lys Gln Lys Ala Pro Asp Glu Glu Val Ile Ala Glu Leu Ser Gln 
            100                 105                 110         


Gln Val Ala Ala Ala Glu Gln Glu Met Asp Glu Gln Ala Lys Ala Ile 
        115                 120                 125             


Cys Gln Tyr Ala Thr Glu Met Ser Thr Gln Thr Leu Ser Tyr Arg Phe 
    130                 135                 140                 


Ala Thr Glu Leu Glu Thr Asn Ile Phe Gly Gln Ile Leu Thr Cys Leu 
145                 150                 155                 160 


Arg Gln Gly Val Phe Ser Thr Phe Asn Ser Asp Ala Arg Asp Val Lys 
                165                 170                 175     


Arg Gly Glu Arg Ser Ile Arg Thr Tyr Lys Lys Gly Met Pro Ile Pro 
            180                 185                 190         


Phe Pro Trp Asn Asp Ser Leu Arg Ile Gly Phe Glu Asp Gly Glu Phe 
        195                 200                 205             


Tyr Leu Arg Trp Tyr Asn Gly Leu Arg Phe Arg Phe Asp Phe Gly Lys 
    210                 215                 220                 


Asp Arg Ser Asn Asn Arg Leu Ile Val Gln Arg Cys Met Lys Met Asp 
225                 230                 235                 240 


Lys Asp Tyr Glu Gly Asp Tyr Lys Leu Cys Asn Ser Ser Ile Gln Met 
                245                 250                 255     


Val Lys Arg Glu Gly Lys Pro Lys Phe Phe Leu Leu Leu Val Val Asn 
            260                 265                 270         


Ile Pro Gln Glu Arg Val Glu Leu Asn Lys Asn Ile Val Val Gly Val 
        275                 280                 285             


Asp Leu Gly Ile Asn Ala Pro Ala Tyr Val Ala Thr Asn Thr Thr Pro 
    290                 295                 300                 


Glu Arg Lys Gln Ile Gly Asp Arg Glu His Phe Leu Asn Glu Arg Met 
305                 310                 315                 320 


Ala Phe Gln Arg Arg Phe Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr 
                325                 330                 335     


Gly Gly Arg Gly Arg Ala Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg 
            340                 345                 350         


Lys Ala Glu Gln Asn Trp Val His Thr Gln Asn His Leu Phe Ser Arg 
        355                 360                 365             


Glu Val Ile Asp Phe Ala Val Lys Ala Arg Ala Ala Thr Ile His Met 
    370                 375                 380                 


Glu Asp Leu Ser Gly Phe Gly Lys Asp Arg Asp Gly Asn Ala Asp Glu 
385                 390                 395                 400 


Arg Lys Glu Phe Val Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn 
                405                 410                 415     


Met Ile Thr Tyr Lys Ala Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile 
            420                 425                 430         


Arg Pro Ala Tyr Thr Ser Lys Thr Cys Ser Trp Cys Gly His Gln Gly 
        435                 440                 445             


Phe Arg Glu Gly Ile Thr Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys 
    450                 455                 460                 


Phe Gly Glu Lys Glu His Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala 
465                 470                 475                 480 


Asn Ser Lys Glu Ile Ile Lys Asn Asn Glu Glu 
                485                 490     


<210>  32
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.295231

<400>  32

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu His Leu Cys Thr Glu Glu 
1               5                   10                  15      


Leu Ser Asp Glu Gln Gln Lys Ala Gln Arg Leu Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Val Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Leu Lys His Asp Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Arg Glu Leu Ala Arg Ala Glu Lys Lys Ala Asp Asp 
65                  70                  75                  80  


Glu Leu Ala Thr Gln Leu Arg Glu Lys Leu Val Ala Ala Glu Arg Glu 
                85                  90                  95      


Met Thr Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu Met Ser 
            100                 105                 110         


Thr Gln Ser Leu Ser Tyr Arg Phe Val Thr Glu Leu Glu Thr Lys Ile 
        115                 120                 125             


Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Tyr Ala Thr Phe 
    130                 135                 140                 


Asn Ser Asp Ser Arg Asp Val Lys Arg Gly Glu Arg Ala Ile Arg Asn 
145                 150                 155                 160 


Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser Val Arg 
                165                 170                 175     


Ile Glu Tyr Glu Glu Lys Glu Lys Asp Phe Phe Leu Arg Trp Tyr Asn 
            180                 185                 190         


Asp Ile Arg Phe Lys Phe His Phe Gly Arg Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Ser Arg Cys Met Lys Leu Asp Lys Asp Tyr Glu Gly Asp 
    210                 215                 220                 


Tyr Gln Leu Cys Asn Ser Ser Ile Gln Ile Val Lys Arg Asp Gly Ser 
225                 230                 235                 240 


Thr Lys Tyr Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Ile Asn Tyr 
            260                 265                 270         


Pro Ala Phe Ala Ala Thr Asn Cys Thr Glu Glu Arg Met Ser Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Thr Arg Met Gln Phe Gln Arg Arg Phe 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr Gly Gly Lys Gly Arg Asn 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Leu Lys Val Val Asn Phe Ala 
            340                 345                 350         


Val Gln Ala His Ala Ala Thr Ile His Leu Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asp Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Lys Tyr Lys Ala 
385                 390                 395                 400 


Lys Lys Phe Gly Ile Gln Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Gln Thr Cys Ser Trp Cys Gly Gln Arg Gly Phe Arg Gln Gly Ile Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys Cys Gly Glu Lys Glu Asn 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Asp Lys Asp Glu 
465                 


<210>  33
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.292139

<400>  33

Met Pro Ile Ile Thr Arg Lys Ile Glu Leu His Ile Ser Lys Glu Gly 
1               5                   10                  15      


Leu Ser Ala Glu Asp Tyr Lys Ala Gln Trp Gln Tyr Leu Arg Gln Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Met Ala Ala Asn Arg Val Ser Ser His Cys Phe 
        35                  40                  45              


Leu Asn Asp Glu Tyr Lys Tyr Arg Leu Cys Leu Gln Ile Pro Asp Tyr 
    50                  55                  60                  


Ile Asp Ile Glu Lys Gln Leu Lys Asp Ser Lys Arg Ala Arg Leu Ser 
65                  70                  75                  80  


Lys Glu Glu Leu Gly Gln Leu Lys Lys Arg Lys Lys Glu Leu Glu Asn 
                85                  90                  95      


Thr Val Lys Gly Arg Phe Gln Asp Glu Phe Glu Lys Asn Ser Leu Tyr 
            100                 105                 110         


Thr Ile Ile Ser Asn Glu Phe Gly Glu Ile Ile Pro Gly Gln Ile Leu 
        115                 120                 125             


Thr Cys Leu Arg Gln Cys Val Gln Ser Lys Tyr Asn Arg Ala Lys Glu 
    130                 135                 140                 


Glu Leu Glu Lys Gly Glu Arg Ala Ile Ser Thr Tyr Lys Lys Gly Met 
145                 150                 155                 160 


Pro Ile Pro Phe Pro Ile Asn Lys Ser Ile Arg Leu Gln Lys Gln Gly 
                165                 170                 175     


Glu Asp Phe Val Leu Lys Trp Tyr Asn Lys Ile Val Phe Lys Leu His 
            180                 185                 190         


Phe Gly Arg Asp Arg Ser Asn Asn Arg Val Ile Val Glu Arg Leu Ile 
        195                 200                 205             


Gln Ser Ala Leu Asn Asp Lys Gln Lys Gly Glu Asp Tyr Val Met Asn 
    210                 215                 220                 


Asn Ser Ser Ile Gln Leu Val Glu Lys Asp Lys Met Thr Lys Ile Phe 
225                 230                 235                 240 


Leu Leu Leu Ser Met Asp Ile Pro Thr Gln Lys Arg Lys Leu Asp Ser 
                245                 250                 255     


Glu Leu Val Leu Gly Val Asp Leu Gly Leu Asn Phe Pro Leu Tyr Tyr 
            260                 265                 270         


Ala Thr Asn Gln Ser Ala Asn Ile His Asp His Ile Gly Asp Lys Asp 
        275                 280                 285             


Ile Phe Leu Lys Glu Arg Met Val Phe Gln Arg Arg Phe Lys Glu Leu 
    290                 295                 300                 


Gln Arg Leu Gln Cys Thr Gln Gly Gly Arg Gly Arg Lys Lys Lys Leu 
305                 310                 315                 320 


Glu Pro Leu Glu Lys Leu Arg Asp Lys Glu Arg Asn Trp Val Arg Thr 
                325                 330                 335     


Lys Asn His Ile Phe Ser Arg Glu Val Ile Lys Val Ala Leu His Leu 
            340                 345                 350         


Gly Ala Gly Thr Ile His Leu Glu Asn Leu His Asn Phe Gly Lys Asp 
        355                 360                 365             


Gly Asn Gly Glu Leu Lys Asn Ser Lys Lys Phe Val Phe Arg Asn Trp 
    370                 375                 380                 


Ser Tyr Phe Glu Leu Gln Ser Met Ile Glu Tyr Lys Ala Lys Met Glu 
385                 390                 395                 400 


Gly Ile Thr Val Lys Tyr Val Asn Pro Ala Tyr Thr Ser Gln Thr Cys 
                405                 410                 415     


Ser Val Cys Gly Met Ile Gly Glu Arg Lys Glu Gln Ala Val Phe Arg 
            420                 425                 430         


Cys Met Asn Ser Ser Cys Leu Glu Tyr Gly Lys Glu Val Asn Ala Asp 
        435                 440                 445             


Phe Asn Ala Ala Arg Asn Ile Ala Lys Ala Lys Met 
    450                 455                 460 


<210>  34
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.279423

<400>  34

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Asp Gly 
1               5                   10                  15      


Leu Ser Asp Asp Leu Arg Lys Asp Gln Trp Gln Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ala Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Gly Leu Ile Lys Glu Leu Ala Lys Ala Arg Lys Arg Ala Asp Asp 
65                  70                  75                  80  


Glu Ala Val Arg Asp Leu Cys Ser Lys Leu Ala Val Ala Glu Gln Glu 
                85                  90                  95      


Met Asn Glu Gln Ala Lys Ala Ile Cys Asp Tyr Ala Thr Glu Met Ser 
            100                 105                 110         


Thr Gln Thr Leu Ser Tyr Asn Phe Ala Lys Glu Ile Glu Thr Asn Ile 
        115                 120                 125             


Phe Gly Gln Ile Leu Thr Cys Leu Arg Gln Gly Val Leu Leu Asn Phe 
    130                 135                 140                 


Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile Arg Asn 
145                 150                 155                 160 


Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asp Thr Ile Lys 
                165                 170                 175     


Ile Val Ser Glu Gly Asp Glu Phe Tyr Leu Arg Trp Phe Ser Gly Leu 
            180                 185                 190         


Arg Phe His Leu Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg Met Ile 
        195                 200                 205             


Val Arg Arg Cys Leu Lys Met Glu Gln Asp Phe Asp Glu Glu Tyr Lys 
    210                 215                 220                 


Ile Ser Asn Ser Ser Ile Gln Val Ala Lys Arg Asp Gly Lys Gln Lys 
225                 230                 235                 240 


Leu Phe Leu Leu Leu Val Val Gln Ile Pro Gln Glu Gln Val Val Leu 
                245                 250                 255     


Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Val Asn Val Pro Ala 
            260                 265                 270         


Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly Asp Arg 
        275                 280                 285             


Glu His Phe Leu Asn Thr Arg Met Gln Phe Gln Arg Arg Tyr Lys Ser 
    290                 295                 300                 


Leu Gln Arg Leu Lys Thr Thr Glu Gly Gly Arg Gly Arg Ala Lys Lys 
305                 310                 315                 320 


Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp Val His 
                325                 330                 335     


Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asn Phe Ala Leu Gln 
            340                 345                 350         


Thr Gln Ala Ala Thr Ile Asn Met Glu Asp Leu Ser Gly Phe Gly Lys 
        355                 360                 365             


Asp Asn Asp Gly Asn Ala Asp Glu Cys Lys Glu Phe Val Leu Arg Asn 
    370                 375                 380                 


Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Val Tyr Lys Ala Ser Lys 
385                 390                 395                 400 


Tyr Gly Ile Arg Val Gln Lys Ile Arg Pro Ala Tyr Thr Ser Lys Thr 
                405                 410                 415     


Cys Ser Trp Cys Gly His Met Gly Phe Arg Glu Gly Val Thr Phe Ile 
            420                 425                 430         


Cys Glu Asn Pro Asp Cys Lys Gln Phe Gly Glu Lys Val His Ala Asp 
        435                 440                 445             


Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Glu Ile Ile Lys Asn 
    450                 455                 460                 


Asp Glu 
465     


<210>  35
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.20054

<400>  35

Met Ser Lys Thr Val Thr Lys Thr Val Lys Ile Ala Leu Ile Cys Glu 
1               5                   10                  15      


His Thr Asn Lys Tyr Gly Glu Lys Val Asp Tyr Lys Asp Ile Asn Lys 
            20                  25                  30          


Leu Leu Trp Lys Leu Gln Lys Gln Thr Arg Glu Leu Lys Asn Lys Thr 
        35                  40                  45              


Ile Gln Leu Cys Trp Glu Tyr Asn Asn Phe Ser Cys Asp Tyr Tyr Lys 
    50                  55                  60                  


Glu His His Glu Tyr Pro Asn Met Glu Asp Ile Leu Lys Tyr Lys Arg 
65                  70                  75                  80  


Ile Asn Gly Phe Val Glu Asn Lys Leu Lys Thr Val Asn Asp Leu Tyr 
                85                  90                  95      


Ser Ser Asn Cys Ser Thr Thr Ile Leu Ser Thr Cys Asn Glu Phe Gln 
            100                 105                 110         


Asn Tyr Arg Ser Glu Phe Leu Lys Gly Thr Arg Ser Ile Asn Ser Tyr 
        115                 120                 125             


Lys Ser Asp Gln Pro Leu Asp Leu His Lys Gly Ala Ile Lys Leu Glu 
    130                 135                 140                 


His Asp Gly Lys Asp Phe Tyr Val Ser Leu Lys Leu Leu Lys Arg Ser 
145                 150                 155                 160 


Ala Phe Asn Ala Met Glu Phe Lys Gly Ser Asp Ile Arg Phe Lys Leu 
                165                 170                 175     


Asn Val Lys Asp Lys Asp Lys Ser Thr Leu Lys Ile Leu Glu Ser Cys 
            180                 185                 190         


Tyr Asp Lys Ile Tyr Ser Ile Ser Ala Ser Lys Met Thr Tyr Asp Arg 
        195                 200                 205             


Lys Ala Gly Lys Trp Phe Leu Leu Leu Ala Tyr Ser Phe Thr Pro Ala 
    210                 215                 220                 


Lys Thr Glu Asn Leu Asp Pro Glu Lys Ile Leu Gly Val Asp Leu Gly 
225                 230                 235                 240 


Ile Lys Ile Pro Ile Cys Ala Ser Val Tyr Gly Asp Leu Asp Arg Leu 
                245                 250                 255     


Thr Ile Glu Gly Gly Lys Ile Glu Glu Phe Arg Arg Arg Val Glu Ala 
            260                 265                 270         


Arg Lys Arg Ser Leu Gln Lys Gln Gly Lys Gln Cys Gly Asp Gly Arg 
        275                 280                 285             


Ile Gly His Gly Thr Lys Lys Arg Ile Lys Pro Ile Thr Asp Ile Gly 
    290                 295                 300                 


Asp Lys Ile Ala Arg Phe Arg Asp Thr Glu Asn His Ile Tyr Ser Arg 
305                 310                 315                 320 


Tyr Leu Ile Glu Tyr Ala Val Lys Lys Gly Cys Gly Thr Ile Gln Met 
                325                 330                 335     


Glu Lys Leu Glu Gly Ile Thr Arg Glu Lys Asp Ile Phe Leu Lys Asn 
            340                 345                 350         


Trp Thr Tyr Phe Asp Leu Gln Lys Lys Ile Glu Tyr Lys Ala Lys Glu 
        355                 360                 365             


Lys Gly Ile Lys Val Val Tyr Ile Glu Pro Ala Tyr Thr Ser Lys Arg 
    370                 375                 380                 


Cys Ser Ser Cys Gly Phe Ile Asp Thr Asp Asn Arg Leu Asp Gln Ala 
385                 390                 395                 400 


His Phe Lys Cys Leu Lys Cys Gly Phe Asn Glu Asn Ala Asp Tyr Asn 
                405                 410                 415     


Ala Ser Gln Asn Ile Gly Ile Lys Asn Ile Asp Lys Ile Ile Lys Glu 
            420                 425                 430         


Glu His Lys Ser Ala Ser Asp Lys Leu Thr Ser Glu 
        435                 440                 


<210>  36
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.282673

<400>  36

Val Ile Ile Leu Thr Lys Val Val Lys Leu Tyr Leu Ile Ser Glu Gln 
1               5                   10                  15      


Ile Asn Lys Glu Gly Gln Lys Ile Asp Tyr Gln Arg Ile Asn Ser Ile 
            20                  25                  30          


Leu Trp Asp Leu Gln Lys Gln Thr Arg Asp Ile Lys Asn Arg Thr Val 
        35                  40                  45              


Gln Leu Cys Trp Glu Trp Met Asn Phe Ser Ser Asp Tyr Cys Lys Thr 
    50                  55                  60                  


Gln Glu Glu Tyr Pro Lys Glu Arg Asp Ile Leu Gly Tyr Thr Leu Glu 
65                  70                  75                  80  


Gly Tyr Val Tyr Asp Tyr Phe Lys Thr Gly Tyr Asp Leu Tyr Thr Gly 
                85                  90                  95      


Asn Ile Ser Thr Ser Ser Arg Glu Val Cys Ser Ser Phe Lys Asn Val 
            100                 105                 110         


Lys Lys Glu Ile Leu Lys Gly Glu Arg Ser Ile Leu Ser Tyr Lys Ala 
        115                 120                 125             


Asn Gln Pro Leu Asp Leu His Lys Lys Ala Ile Ser Leu Glu Tyr Asp 
    130                 135                 140                 


Asn Phe Asn Phe Phe Val Lys Leu Lys Leu Leu Asn Arg Thr Gly Lys 
145                 150                 155                 160 


Lys Lys Tyr Asp Ile Thr Glu Asp Ile Asn Phe Lys Ile Gln Val Asn 
                165                 170                 175     


Asp Lys Ser Thr Arg Thr Ile Leu Glu Arg Cys Tyr Asp Lys Glu Tyr 
            180                 185                 190         


Lys Ile Ser Gly Ser Lys Leu Ile Tyr Glu Lys Lys Lys Lys Leu Trp 
        195                 200                 205             


Arg Leu Asn Leu Cys Tyr Ser Phe Glu Asn Ser Gln Val Glu Thr Leu 
    210                 215                 220                 


Glu Lys Asp Lys Ile Leu Gly Ile Asp Leu Gly Ile Val Tyr Pro Leu 
225                 230                 235                 240 


Met Ala Ser Ile Tyr Gly Glu Tyr Asp Arg Phe Ser Ile Lys Gly Gly 
                245                 250                 255     


Glu Ile Glu Glu Phe Arg Arg Arg Thr Glu Ala Arg Lys Arg Ser Ile 
            260                 265                 270         


Leu Gln Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Arg 
        275                 280                 285             


Asn Lys Arg Thr Gln Pro Ala Tyr Lys Ile Asn Asp Lys Ile Ala Arg 
    290                 295                 300                 


Phe Arg Asp Thr Ala Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr 
305                 310                 315                 320 


Ala Val Lys Lys Asn Cys Gly Ile Ile Gln Met Glu Asn Leu Thr Gly 
                325                 330                 335     


Ile Ser Asp Asn Thr Asp Cys Phe Leu Lys Asp Trp Ser Tyr Tyr Asp 
            340                 345                 350         


Leu Gln Thr Lys Ile Glu Asn Lys Ala Lys Glu Met Gly Ile Lys Val 
        355                 360                 365             


Val Tyr Ile Lys Ala Gln Tyr Thr Ser Gln Arg Cys Ser Arg Cys Gly 
    370                 375                 380                 


Tyr Ile Asp Val Asn Asn Arg Ile Arg Gln Ala Leu Phe Lys Cys Gln 
385                 390                 395                 400 


Asn Cys Gly Tyr Glu Thr Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile 
                405                 410                 415     


Gly Met Tyr Asp Ile Glu Asn Ile Ile Glu Glu Thr Leu Lys Ile Gln 
            420                 425                 430         


Ser Ala Asn Val Lys Gln Ser 
        435                 


<210>  37
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.282952

<400>  37

Met Thr Lys Val Thr Lys Val Tyr Leu Ile Ser Glu Gln Ile Asp Lys 
1               5                   10                  15      


Asp Gly Asn Lys Ile Asp Phe Lys Lys Ile Ser Glu Leu Leu Trp Asn 
            20                  25                  30          


Leu Gln Met Gln Thr Arg Asp Ile Lys Asn Lys Cys Val Gln Leu Cys 
        35                  40                  45              


Trp Glu Trp Leu Asn Phe Ser Ser Asp Tyr Tyr Lys Lys Ser Glu Glu 
    50                  55                  60                  


Tyr Pro Lys Glu Lys Asp Thr Leu Gly Tyr Thr Leu Ser Gly Phe Val 
65                  70                  75                  80  


Tyr Asp Arg Ile Lys Asn Gly Ser Asp Leu Tyr Ser Ser Asn Leu Ser 
                85                  90                  95      


Thr Ser Ser Arg Asp Thr Cys Thr Ala Phe Ser Asn Tyr Lys Lys Glu 
            100                 105                 110         


Met Leu Lys Gly Glu Arg Ser Val Leu Ser Phe Lys Ala Asn Gln Pro 
        115                 120                 125             


Leu Asp Ile His Asn Lys Ala Ile Lys Leu Ser Tyr Glu Asn Gly Asn 
    130                 135                 140                 


Phe Phe Val Ala Leu Lys Met Leu Asn Arg Ala Gly Lys Glu Lys Tyr 
145                 150                 155                 160 


Gly Ile Lys Asp Asp Leu Arg Phe Arg Met Gln Val Arg Asp Lys Ser 
                165                 170                 175     


Val Arg Thr Ile Leu Glu Arg Leu Met Asn Asp Glu Tyr Lys Val Ser 
            180                 185                 190         


Ala Ser Lys Leu Met Tyr Asp Lys Lys Lys Lys Leu Trp Lys Leu Asn 
        195                 200                 205             


Leu Cys Tyr Ser Phe Asp Asn His Val Ile Ser Thr Leu Asp Thr Glu 
    210                 215                 220                 


Lys Ile Met Gly Val Asp Leu Gly Val Val Tyr Pro Ile Met Ala Ser 
225                 230                 235                 240 


Val Asn Gly Asp Tyr Ala Arg Phe Ser Ile Lys Gly Gly Glu Ile Glu 
                245                 250                 255     


Ala Phe Arg Ser Arg Val Glu Ala Arg Arg Arg Ser Leu Leu Asn Gln 
            260                 265                 270         


Ser Arg Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Arg Lys Lys Arg 
        275                 280                 285             


Thr Glu Pro Ala Thr Gln Ile Ala Asp Lys Ile Ala Arg Phe Arg Asp 
    290                 295                 300                 


Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Asp Tyr Ala Ile Lys 
305                 310                 315                 320 


Asn Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr Gly Ile Thr Ser 
                325                 330                 335     


Ser Ala Glu His Phe Leu Lys Glu Trp Ser Tyr Phe Asp Leu Gln Thr 
            340                 345                 350         


Lys Ile Glu Ser Lys Ala Lys Glu Ala Gly Ile Lys Val Val Tyr Ile 
        355                 360                 365             


Asn Pro Lys Phe Thr Ser Gln Arg Cys Asn Lys Cys Gly Tyr Ile His 
    370                 375                 380                 


Thr Asp Asn Arg Pro Val Gln Ala Arg Phe Cys Cys Gln Lys Cys Gly 
385                 390                 395                 400 


Tyr Glu Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Gly Thr Lys 
                405                 410                 415     


His Ile Asp Val Ile Ile Glu Glu Thr Leu Lys Met Gln Cys Glu Pro 
            420                 425                 430         


Glu Thr Pro Thr Glu 
        435         


<210>  38
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.283262

<400>  38

Met Asn Lys Val Val Lys Leu Ala Leu Ile Cys Glu Gln Ser Asp Lys 
1               5                   10                  15      


Asp Asn Ser Pro Val Asp Tyr Lys Lys Ile Asn Glu Ile Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Glu Ile Lys Asn Lys Ala Ile Gln Tyr Cys 
        35                  40                  45              


Trp Glu Tyr Asn Asn Phe Ser Ser Asp Tyr Tyr Lys Lys Phe Asn Glu 
    50                  55                  60                  


Tyr Pro Lys Glu Lys Asp Ile Leu Ser Tyr Thr Leu Val Gly Phe Val 
65                  70                  75                  80  


Asn Asp Lys Phe Lys Thr Gly Asn Asp Leu Tyr Ser Gly Asn Cys Ser 
                85                  90                  95      


Thr Thr Val Arg Asn Ala Cys Thr Glu Phe Lys Asn Ser Lys Lys Glu 
            100                 105                 110         


Leu Ile Lys Gly Ser Arg Ser Ile Ile Asn Tyr Arg Ser Asn Gln Pro 
        115                 120                 125             


Leu Asp Ile His Asn Lys Cys Ile Arg Ile Glu Phe Glu Asn Asn Cys 
    130                 135                 140                 


Phe Tyr Thr Tyr Leu Lys Leu Leu Asn Arg Pro Ala Phe Lys Lys Tyr 
145                 150                 155                 160 


Asn Phe Ala Asn Thr Glu Ile Lys Phe Lys Ile Leu Val Arg Asp Asn 
                165                 170                 175     


Ser Thr Lys Thr Ile Leu Glu Arg Cys Ile Ser Asn Glu Tyr Glu Ile 
            180                 185                 190         


Ala Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Cys Trp Phe Leu 
        195                 200                 205             


Asn Leu Val Tyr Ala Phe Glu Ile Lys Ser Asn Asn Ser Leu Asp Pro 
    210                 215                 220                 


Asn Lys Ile Leu Gly Val Asp Leu Gly Ile His Tyr Pro Ile Cys Ala 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Leu Asp Arg Phe Thr Ile Asp Gly Gly Glu Ile 
                245                 250                 255     


Asp Glu Phe Arg Arg Arg Val Glu Ser Arg Lys Ile Ser Met Leu Lys 
            260                 265                 270         


Gln Gly Lys Asn Cys Gly Asp Gly Arg Ile Gly His Gly Ile Lys Ala 
        275                 280                 285             


Arg Asn Lys Pro Val Tyr Asn Ile Glu Asp Lys Ile Ala Arg Phe Arg 
    290                 295                 300                 


Asp Thr Ala Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr Ala Val 
305                 310                 315                 320 


Lys His Thr Cys Gly Thr Ile Gln Met Glu Asp Leu Thr Gly Ile Thr 
                325                 330                 335     


Asp Ile Ala Asn Arg Phe Leu Lys Asn Trp Ser Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Thr Lys Ile Glu Tyr Lys Ala Lys Glu Ala Gly Ile Asn Ile Val Tyr 
        355                 360                 365             


Ile Asp Pro Lys Asn Thr Ser Arg Arg Cys Ser Lys Cys Gly Tyr Ile 
    370                 375                 380                 


Asp Lys Glu Asn Arg Glu Thr Gln Ser Arg Phe Ile Cys Leu Lys Cys 
385                 390                 395                 400 


Gly Phe Lys Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Gly Ile 
                405                 410                 415     


Lys Asp Ile Asp Lys Leu Ile Lys Glu Asp Val His 
            420                 425             


<210>  39
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.284833

<400>  39

Val Thr Leu Leu Val Lys Val Val Lys Ile Tyr Leu Ile Ser Glu Gln 
1               5                   10                  15      


Phe Asp Lys Ala Gly Asn Gln Ile Asp Tyr Lys Glu Val Asn Lys Ile 
            20                  25                  30          


Leu Trp Glu Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Thr Val 
        35                  40                  45              


Gln Leu Leu Trp Glu Trp Asn Asn Phe Ser Ser Asp Tyr Val Lys Ala 
    50                  55                  60                  


Ser Gly Ile Tyr Pro Lys Ala Lys Asp Ile Phe Gly Tyr Ser Ser Val 
65                  70                  75                  80  


His Gly Gln Ala Asn Lys Glu Leu Arg Thr Lys Leu Ala Leu Asn Ser 
                85                  90                  95      


Ser Asn Leu Ser Thr Thr Thr Met Asp Val Cys Lys Ile Phe Asn Thr 
            100                 105                 110         


Tyr Lys Lys Glu Val Trp Glu Gly Lys Arg Ser Val Pro Ser Tyr Lys 
        115                 120                 125             


Ser Asp Gln Pro Leu Asp Leu His Lys Glu Ser Ile Lys Leu Ile Tyr 
    130                 135                 140                 


Glu Asn Asn Glu Phe Tyr Val Arg Leu Ala Leu Leu Lys Lys Ala Glu 
145                 150                 155                 160 


Phe Ala Lys Tyr Gly Phe Lys Asp Gly Phe Arg Phe Lys Met Gln Val 
                165                 170                 175     


Lys Asp Asn Ser Thr Lys Thr Ile Leu Glu Arg Cys Phe Asp Glu Val 
            180                 185                 190         


Tyr Lys Ile Asn Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Lys 
        195                 200                 205             


Trp Lys Leu Asn Leu Ser Tyr Ser Phe Asp Asn Lys Asn Ile Ser Glu 
    210                 215                 220                 


Leu Asp Lys Glu Lys Ile Leu Gly Val Asp Val Gly Val Asn Cys Pro 
225                 230                 235                 240 


Leu Val Ala Ser Val Phe Gly Asp Arg Asp Arg Phe Ile Ile Lys Gly 
                245                 250                 255     


Gly Glu Ile Glu Lys Phe Arg Lys Ser Val Glu Ala Arg Arg Arg Ser 
            260                 265                 270         


Met Leu Glu Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly 
        275                 280                 285             


Arg Lys Lys Arg Thr Glu Pro Ala Leu Asn Ile Gly Asp Lys Ile Ala 
    290                 295                 300                 


Arg Phe Arg Asp Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Glu 
305                 310                 315                 320 


Tyr Ala Val Lys Lys Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr 
                325                 330                 335     


Gly Ile Thr Ser Lys Ser Asp Arg Phe Leu Lys Asp Trp Thr Tyr Tyr 
            340                 345                 350         


Asp Leu Gln Thr Lys Ile Glu Asn Lys Ala Lys Glu Val Gly Ile Asn 
        355                 360                 365             


Val Val Tyr Ile Ala Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys 
    370                 375                 380                 


Gly Tyr Ile His Lys Asp Asn Arg Pro Asn Gln Ala Lys Phe Arg Cys 
385                 390                 395                 400 


Leu Glu Cys Asp Phe Glu Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
                405                 410                 415     


Ile Gly Ile Lys Asn Ile Asp Lys Ile Ile Glu Lys Asp Leu Gln Lys 
            420                 425                 430         


Gln Glu Ser Glu Val Gln Val Asn Glu Asn Lys 
        435                 440             


<210>  40
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.287700

<400>  40

Met Asn Lys Val Val Lys Leu Ala Leu Ile Cys Glu Gln Ser Asp Lys 
1               5                   10                  15      


Asn Asn Ser Pro Val Asp Tyr Lys Lys Val Asn Glu Ile Leu Trp Glu 
            20                  25                  30          


Leu Gln Lys Gln Thr Arg Glu Ile Lys Asn Lys Thr Ile Gln Tyr Cys 
        35                  40                  45              


Trp Glu Tyr Tyr Asn Phe Ser Ser Asp Tyr Tyr Lys Lys Phe Asn Lys 
    50                  55                  60                  


Tyr Pro Lys Glu Lys Asp Ile Leu Ser Tyr Thr Leu Trp Gly Phe Ile 
65                  70                  75                  80  


Asn Asp Lys Phe Lys Thr Gly Asn Asp Leu Tyr Ser Gly Asn Cys Ser 
                85                  90                  95      


Ala Thr Thr Lys Lys Val Ile Lys Glu Phe Lys Asn Ser Lys Lys Glu 
            100                 105                 110         


Leu Ile Arg Gly Ser Arg Ser Ile Ile Asn Tyr Lys Ser Asn Gln Pro 
        115                 120                 125             


Leu Asn Ile His Asn Lys Cys Ile His Leu Gln Phe Lys Asn Asn Asn 
    130                 135                 140                 


Phe Tyr Val Ser Ile Asn Leu Leu Asn Arg Arg Ser Phe Lys Lys Tyr 
145                 150                 155                 160 


Asn Phe Ala Asn Thr Ala Ile Lys Phe Lys Ile Leu Val Arg Asp Asn 
                165                 170                 175     


Ser Thr Lys Ala Ile Leu Glu Arg Cys Ile Ser Asn Glu Tyr Lys Ile 
            180                 185                 190         


Ser Glu Ser Gln Leu Ile Tyr Asn Lys Lys Lys Lys Cys Trp Phe Leu 
        195                 200                 205             


Asn Leu Ser Tyr Ala Phe Glu Ile Lys Ser Asn Asn Ser Leu Asp Pro 
    210                 215                 220                 


Asn Lys Ile Leu Gly Val Asp Leu Gly Ile His Tyr Pro Ile Cys Ala 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Leu Asp Arg Phe Thr Ile Asp Gly Gly Glu Ile 
                245                 250                 255     


Asp Glu Phe Arg Arg Arg Val Glu Ser Arg Lys Ile Ser Met Leu Lys 
            260                 265                 270         


Gln Gly Lys Asn Cys Gly Asp Gly Arg Ile Gly His Gly Ile Lys Ala 
        275                 280                 285             


Arg Asn Lys Pro Val Tyr Asn Ile Glu Asp Lys Ile Ala Arg Phe Arg 
    290                 295                 300                 


Asp Thr Ala Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr Ala Val 
305                 310                 315                 320 


Lys Asn Asn Cys Gly Thr Ile Gln Met Glu Asp Leu Thr Gly Ile Thr 
                325                 330                 335     


Asp Asn Ala Asn Arg Phe Leu Lys Asn Trp Ser Tyr Tyr Asp Leu Gln 
            340                 345                 350         


Thr Lys Ile Glu Tyr Lys Ala Lys Glu Ala Ser Ile Asn Val Val Tyr 
        355                 360                 365             


Ile Asn Pro Glu Asn Thr Ser Arg Arg Cys Ser Lys Cys Gly Tyr Ile 
    370                 375                 380                 


Asp Lys Glu Asn Arg Lys Thr Gln Ser Ser Phe Ile Cys Leu Lys Cys 
385                 390                 395                 400 


Gly Phe Lys Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Ser Ile 
                405                 410                 415     


Lys Asp Ile Asp Lys Leu Ile Lys Glu Asp Val His 
            420                 425             


<210>  41
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.291507

<400>  41

Val Thr Leu Leu Val Lys Val Val Lys Ile His Leu Ile Ser Glu Gln 
1               5                   10                  15      


Phe Asp Lys Ala Gly Asn Arg Ile Asp Tyr Glu Glu Val Asn Lys Ile 
            20                  25                  30          


Leu Trp Glu Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Thr Val 
        35                  40                  45              


Gln Leu Leu Trp Glu Trp Asn Asn Phe Ser Ser Asp Tyr Val Lys Ala 
    50                  55                  60                  


Ser Gly Ile Tyr Pro Lys Ala Lys Asp Ile Phe Gly Tyr Ser Ser Val 
65                  70                  75                  80  


His Gly Gln Ala Asn Lys Glu Leu Arg Thr Lys Leu Ala Leu Asn Ser 
                85                  90                  95      


Ser Asn Leu Ser Thr Thr Thr Met Asp Val Cys Lys Asn Phe Asn Thr 
            100                 105                 110         


Tyr Lys Lys Glu Val Trp Lys Gly Lys Arg Ser Val Pro Ser Tyr Lys 
        115                 120                 125             


Ser Asp Gln Pro Leu Asp Leu His Lys Asp Ser Ile Lys Leu Ile Tyr 
    130                 135                 140                 


Glu Asn Asn Gln Phe Tyr Val Arg Leu Ala Leu Leu Lys Lys Ala Glu 
145                 150                 155                 160 


Phe Ala Lys Tyr Gly Phe Lys Asp Gly Phe His Phe Lys Met Gln Val 
                165                 170                 175     


Lys Asp Asn Ser Thr Lys Thr Ile Leu Glu Arg Cys Phe Asp Glu Val 
            180                 185                 190         


Tyr Lys Ile Asn Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Lys 
        195                 200                 205             


Trp Lys Leu Asn Leu Ser Tyr Ser Phe Asp Asn Lys Asn Ile Ser Glu 
    210                 215                 220                 


Leu Asp Lys Glu Lys Ile Leu Gly Val Asp Val Gly Val Ser Tyr Pro 
225                 230                 235                 240 


Leu Val Ala Ser Val Phe Gly Asp Arg Asp Arg Phe Lys Ile Lys Gly 
                245                 250                 255     


Gly Glu Ile Glu Lys Phe Arg Lys Ser Val Glu Ala Arg Arg Arg Ser 
            260                 265                 270         


Met Leu Glu Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly 
        275                 280                 285             


Arg Lys Lys Arg Thr Glu Pro Ala Leu Asn Ile Gly Asp Lys Ile Ala 
    290                 295                 300                 


Arg Phe Arg Asp Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Glu 
305                 310                 315                 320 


Tyr Ala Val Lys Lys Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr 
                325                 330                 335     


Gly Ile Thr Ser Lys Ala Asp Arg Phe Leu Lys Asp Trp Thr Tyr Tyr 
            340                 345                 350         


Asp Leu Gln Thr Lys Ile Glu Asn Lys Ala Lys Glu Val Gly Ile Asn 
        355                 360                 365             


Val Val Tyr Ile Ala Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys 
    370                 375                 380                 


Gly Tyr Ile His Lys Asp Asn Arg Pro Asn Gln Ala Lys Phe Arg Cys 
385                 390                 395                 400 


Leu Glu Cys Asp Phe Glu Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
                405                 410                 415     


Ile Gly Ile Lys Asn Ile Asp Lys Ile Ile Glu Lys Asp Leu Gln Lys 
            420                 425                 430         


Gln Glu Ser Glu Val Gln Val Asn Glu Asn Lys 
        435                 440             


<210>  42
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.293410

<400>  42

Leu Ile Trp Lys Asp Ala Leu Gly Gly Ile Ile Leu Thr Lys Ile Val 
1               5                   10                  15      


Lys Leu Tyr Leu Ile Ser Glu Gln Ile Asp Lys Asp Gly Asn Arg Val 
            20                  25                  30          


Asp Tyr Lys Glu Ile Asn Ser Ile Leu Trp Asn Leu Gln Lys Gln Thr 
        35                  40                  45              


Arg Asp Ile Lys Asn Lys Thr Val Gln Leu Cys Trp Glu Trp Met Asn 
    50                  55                  60                  


Phe Ser Ser Asp Tyr Tyr Lys Lys Asn Glu Leu Tyr Pro Asn Glu Lys 
65                  70                  75                  80  


Glu Ile Leu Asn Leu Thr Leu Arg Gly Tyr Ala Tyr Asp His Phe Lys 
                85                  90                  95      


Gln Gly Tyr Asp Leu Tyr Ser Ser Asn Ile Ser Val Leu Thr Glu Ala 
            100                 105                 110         


Val Cys Gly Ala Phe Lys Asn Ala Lys Lys Glu Met Leu Asn Gly Glu 
        115                 120                 125             


Lys Ser Val Leu Ser Tyr Lys Ala Glu Gln Pro Leu Asp Ile His Lys 
    130                 135                 140                 


Lys Cys Ile Lys Leu Glu Tyr Asp Lys Asn Phe Tyr Val Lys Leu Lys 
145                 150                 155                 160 


Met Leu Asn Lys Ala Gly Lys Lys Lys Tyr Gly Ile Glu Asp Asp Leu 
                165                 170                 175     


Asn Phe Lys Ile Gln Val Glu Asp Lys Ser Thr Arg Thr Ile Leu Glu 
            180                 185                 190         


Arg Cys Ile Asp Gly Glu Tyr Val Val Ser Gly Ser Lys Leu Ile Tyr 
        195                 200                 205             


Asp Lys Lys Lys Lys Leu Trp Lys Leu Asn Leu Cys Tyr Ser Phe Lys 
    210                 215                 220                 


Ala Asn Glu Ile Glu Ser Leu Asp Lys Asn Lys Ile Leu Gly Ile Asp 
225                 230                 235                 240 


Leu Gly Ile Ala Cys Pro Leu Met Ala Ser Val Asn Gly Glu Phe Asp 
                245                 250                 255     


Arg Phe Ser Ile Lys Gly Gly Glu Ile Glu Thr Phe Arg Lys Arg Ile 
            260                 265                 270         


Glu Ala Arg Lys Arg Ser Val Leu His Gln Thr Lys Tyr Cys Gly Asp 
        275                 280                 285             


Gly Arg Ile Gly His Gly Arg Asn Lys Arg Thr Glu Pro Ala Tyr Lys 
    290                 295                 300                 


Ile Asn Asp Lys Ile Ala Arg Phe Arg Asp Thr Ala Asn His Lys Tyr 
305                 310                 315                 320 


Ser Arg Ala Leu Ile Asp Tyr Ala Ile Arg Lys Asn Cys Gly Met Ile 
                325                 330                 335     


Gln Met Glu Asn Leu Thr Gly Ile Ser Asp Lys Lys Glu His Phe Leu 
            340                 345                 350         


Lys Glu Trp Ser Tyr Tyr Asp Leu Gln Thr Lys Ile Glu Asn Lys Ala 
        355                 360                 365             


Lys Glu Lys Gly Ile Lys Ile Val Tyr Ile Asn Pro Glu Tyr Thr Ser 
    370                 375                 380                 


Gln Arg Cys Ser Lys Cys Gly Tyr Ile Asp Ala Asn Asn Arg Glu Leu 
385                 390                 395                 400 


Arg Ala Val Phe Lys Cys Gln Lys Cys Gly Phe Glu Ala Asp Ala Asp 
                405                 410                 415     


Tyr Asn Ala Ser Gln Asn Ile Gly Ile Lys Asn Ile Glu Asp Ile Ile 
            420                 425                 430         


Glu Asn Thr Leu Lys Ile Ser Ser Ala Asn Glu Lys Gln Thr Lys Asn 
        435                 440                 445             


Thr 
    


<210>  43
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.295105

<400>  43

Val Phe Tyr Ser Thr Phe Leu Cys Tyr Ile Leu Thr Lys Tyr Ile Asp 
1               5                   10                  15      


Phe Ser Ala Asn Glu Cys Tyr Asn Ile Asn Thr Ser Ser Glu Val Lys 
            20                  25                  30          


Gln Leu Met Asn Lys Val Val Lys Leu Ala Leu Ile Cys Glu Gln Ser 
        35                  40                  45              


Asp Lys Asp Asn Ser Pro Val Asp Tyr Lys Lys Ile Asn Glu Ile Leu 
    50                  55                  60                  


Trp Glu Leu Gln Lys Gln Thr Arg Glu Ile Lys Asn Lys Ala Ile Gln 
65                  70                  75                  80  


Tyr Cys Trp Glu Tyr Asn Asn Phe Ser Ser Asp Tyr Tyr Lys Lys Phe 
                85                  90                  95      


Asn Glu Tyr Pro Lys Glu Lys Asp Ile Leu Ser Tyr Thr Leu Val Gly 
            100                 105                 110         


Phe Val Asn Asp Lys Phe Lys Thr Gly Asn Asp Leu Tyr Ser Gly Asn 
        115                 120                 125             


Cys Ser Thr Thr Val Arg Asn Ala Cys Thr Glu Phe Lys Asn Ser Lys 
    130                 135                 140                 


Lys Glu Leu Ile Lys Gly Ser Arg Ser Ile Ile Asn Tyr Arg Ser Asn 
145                 150                 155                 160 


Gln Pro Leu Asp Ile His Asn Lys Cys Ile Arg Ile Glu Phe Glu Asn 
                165                 170                 175     


Asn Cys Phe Tyr Thr Tyr Leu Lys Leu Leu Asn Arg Pro Ala Phe Lys 
            180                 185                 190         


Lys Tyr Asn Phe Ala Asn Thr Glu Ile Lys Phe Lys Ile Leu Val Arg 
        195                 200                 205             


Asp Asn Ser Thr Lys Thr Ile Leu Glu Arg Cys Ile Ser Asn Glu Tyr 
    210                 215                 220                 


Glu Ile Ala Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Lys Cys Trp 
225                 230                 235                 240 


Phe Leu Asn Leu Val Tyr Ala Phe Glu Ile Lys Ser Asn Asn Ser Leu 
                245                 250                 255     


Asp Pro Asn Lys Ile Leu Gly Val Asp Leu Gly Ile His Tyr Pro Ile 
            260                 265                 270         


Cys Ala Ser Val Tyr Gly Ser Leu Asp Arg Phe Thr Ile Asp Gly Gly 
        275                 280                 285             


Glu Ile Asp Glu Phe Arg Arg Arg Val Glu Ser Arg Lys Ile Ser Met 
    290                 295                 300                 


Leu Lys Gln Gly Lys Asn Cys Gly Asp Gly Arg Ile Gly His Gly Ile 
305                 310                 315                 320 


Lys Ala Arg Asn Lys Pro Val Tyr Asn Ile Glu Asp Lys Ile Ala Arg 
                325                 330                 335     


Phe Arg Asp Thr Ala Asn His Lys Tyr Ser Arg Ala Leu Ile Glu Tyr 
            340                 345                 350         


Ala Val Lys His Thr Cys Gly Thr Ile Gln Met Glu Asp Leu Thr Gly 
        355                 360                 365             


Ile Thr Asp Ile Ala Asn Arg Phe Leu Lys Asn Trp Ser Tyr Tyr Asp 
    370                 375                 380                 


Leu Gln Thr Lys Ile Glu Tyr Lys Ala Lys Glu Ala Gly Ile Asn Ile 
385                 390                 395                 400 


Val Tyr Ile Asp Pro Lys Asn Thr Ser Arg Arg Cys Ser Lys Cys Gly 
                405                 410                 415     


Tyr Ile Asp Lys Glu Asn Arg Glu Thr Gln Ser Arg Phe Ile Cys Leu 
            420                 425                 430         


Lys Cys Gly Phe Lys Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile 
        435                 440                 445             


Gly Ile Lys Asp Ile Asp Lys Leu Ile Lys Glu Asp Val His 
    450                 455                 460         


<210>  44
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.295187

<400>  44

Leu Ile Ser Glu Gln Ile Asp Lys Asp Gly Asn Arg Val Asp Tyr Lys 
1               5                   10                  15      


Glu Ile Asn Ser Ile Leu Trp Asn Leu Gln Lys Gln Thr Arg Asp Ile 
            20                  25                  30          


Lys Asn Lys Thr Val Gln Leu Cys Trp Glu Trp Met Asn Phe Ser Ser 
        35                  40                  45              


Asp Tyr Tyr Lys Lys Asn Glu Leu Tyr Pro Asn Glu Lys Glu Ile Leu 
    50                  55                  60                  


Asn Leu Thr Leu Arg Gly Tyr Ala Tyr Asp His Phe Lys Gln Gly Tyr 
65                  70                  75                  80  


Asp Leu Tyr Ser Ser Asn Ile Ser Val Leu Thr Glu Ala Val Cys Gly 
                85                  90                  95      


Ala Phe Lys Asn Ala Lys Lys Glu Met Leu Asn Gly Glu Lys Ser Val 
            100                 105                 110         


Leu Ser Tyr Lys Ala Glu Gln Pro Leu Asp Ile His Lys Lys Cys Ile 
        115                 120                 125             


Lys Leu Glu Tyr Asp Lys Asn Phe Tyr Val Lys Leu Lys Met Leu Asn 
    130                 135                 140                 


Lys Ala Gly Lys Lys Lys Tyr Gly Ile Glu Asp Asp Leu Asn Phe Lys 
145                 150                 155                 160 


Ile Gln Val Glu Asp Lys Ser Thr Arg Thr Ile Leu Glu Arg Cys Ile 
                165                 170                 175     


Asp Gly Glu Tyr Val Val Ser Gly Ser Lys Leu Ile Tyr Asp Lys Lys 
            180                 185                 190         


Lys Lys Leu Trp Lys Leu Asn Leu Cys Tyr Ser Phe Lys Ala Asn Glu 
        195                 200                 205             


Ile Glu Ser Leu Asp Lys Asn Lys Ile Leu Gly Ile Asp Leu Gly Ile 
    210                 215                 220                 


Ala Cys Pro Leu Met Ala Ser Val Asn Gly Glu Phe Asp Arg Phe Ser 
225                 230                 235                 240 


Ile Lys Gly Gly Glu Ile Glu Thr Phe Arg Lys Arg Ile Glu Ala Arg 
                245                 250                 255     


Lys Arg Ser Val Leu His Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile 
            260                 265                 270         


Gly His Gly Arg Asn Lys Arg Thr Glu Pro Ala Tyr Lys Ile Asn Asp 
        275                 280                 285             


Lys Ile Ala Arg Phe Arg Asp Thr Ala Asn His Lys Tyr Ser Arg Ala 
    290                 295                 300                 


Leu Ile Asp Tyr Ala Ile Arg Lys Asn Cys Gly Met Ile Gln Met Glu 
305                 310                 315                 320 


Asn Leu Thr Gly Ile Ser Asp Asn Lys Glu His Phe Leu Lys Glu Trp 
                325                 330                 335     


Ser Tyr Tyr Asp Leu Gln Thr Lys Ile Glu Asn Lys Ala Lys Glu Lys 
            340                 345                 350         


Gly Ile Lys Ile Val Tyr Ile Asn Pro Glu Tyr Thr Ser Gln Arg Cys 
        355                 360                 365             


Ser Lys Cys Gly Tyr Ile Asp Ala Asn Asn Arg Glu Leu Arg Ala Val 
    370                 375                 380                 


Phe Lys Cys Gln Asn Cys Gly Phe Glu Ala Asp Ala Asp Tyr Asn Ala 
385                 390                 395                 400 


Ser Gln Asn Ile Gly Ile Lys Asn Ile Glu Asp Ile Ile Glu Asn Thr 
                405                 410                 415     


Leu Lys Ile Ser Ser Ala Asn Glu Lys Gln Thr Lys Asn Thr 
            420                 425                 430 


<210>  45
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.295929

<400>  45

Leu Val Lys Val Val Lys Ile Tyr Leu Ile Ser Glu Gln Val Asp Glu 
1               5                   10                  15      


Gln Gly Lys Asp Val Asp Tyr Asn Thr Ile Cys Gly Val Leu Trp Asp 
            20                  25                  30          


Leu Gln Trp Glu Thr Arg Glu Ile Lys Asn Lys Thr Val Gln Leu Cys 
        35                  40                  45              


Trp Glu Trp Ser Gly Phe Ser Ser Asp Tyr Tyr Lys Lys Tyr Gly Glu 
    50                  55                  60                  


Tyr Pro Lys Glu Lys Asn Leu Leu Asp Tyr Thr Met Gly Gly Phe Val 
65                  70                  75                  80  


Tyr Asp Lys Leu Lys Ser Lys Tyr His Leu Tyr Thr Ala Asn Leu Ser 
                85                  90                  95      


Thr Thr Ser Gln Asn Thr Cys Gly Ile Phe Arg Thr Tyr Lys Val Asp 
            100                 105                 110         


Phe Val Lys Gly Asn Arg Ser Val Leu Ser Phe Lys Ala Asp Gln Pro 
        115                 120                 125             


Leu Asp Val His Lys Lys Ser Ile Ser Ile Asp Arg Ile Asp Asp Asn 
    130                 135                 140                 


Tyr Phe Val Lys Leu Lys Leu Leu Asn Lys Ser Gly Ile Gln Lys Tyr 
145                 150                 155                 160 


Gly Ile Arg Asp Asp Phe His Phe Arg Met Leu Val Lys Asp Asn Ser 
                165                 170                 175     


Thr Lys Thr Ile Leu Glu Arg Cys Val Gly Gly Asp Tyr Lys Ala Ala 
            180                 185                 190         


Ala Ser Lys Ile Ile Tyr Asp Lys Lys Lys Lys Met Trp Cys Leu Asn 
        195                 200                 205             


Leu Ser Tyr Glu Phe Asp Val Asn Thr Ala Lys Asp Leu Asn Lys Asn 
    210                 215                 220                 


Arg Ile Leu Gly Ile Asp Ile Gly Ile Val Tyr Pro Val Val Ala Ser 
225                 230                 235                 240 


Val Asn Gly Glu Leu Asp Arg Phe Val Ile Gln Gly Gly Glu Ile Glu 
                245                 250                 255     


Thr Phe Arg Arg Arg Val Glu Asn Arg Lys Lys Ser Leu Leu Lys Gln 
            260                 265                 270         


Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly Arg Asn Lys Arg 
        275                 280                 285             


Thr Glu Pro Val Asp Ile Ile Ser Asp Gln Ile Ala Arg Phe Arg Asn 
    290                 295                 300                 


Thr Ala Asn His Lys Tyr Ser Arg Ala Val Ile Asp Tyr Ala Val Arg 
305                 310                 315                 320 


Lys Gln Cys Gly Thr Ile Gln Met Glu Asn Leu Lys Gly Ile Thr Asp 
                325                 330                 335     


Lys Ser Asp Arg Phe Leu Lys Asn Trp Ser Tyr Tyr Asp Leu Gln Gln 
            340                 345                 350         


Lys Ile Glu Tyr Lys Ala Lys Glu Lys Gly Ile Asn Val Val Phe Ile 
        355                 360                 365             


Asn Pro Lys Tyr Thr Ser Gln Arg Cys Ser Arg Cys Gly Tyr Ile Asp 
    370                 375                 380                 


Ser Ala Asn Arg Pro Lys Leu Pro Asn Gln Ser Lys Phe Leu Cys Ile 
385                 390                 395                 400 


Lys Cys Gly Phe Thr Glu Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile 
                405                 410                 415     


Ala Leu Tyr Asn Ile Glu Lys Leu Ile Asp Ala Glu Ala 
            420                 425                 


<210>  46
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.298706 guide nucleic acid

<400>  46
cguugcagcu cgcacguugg cacugguuga agguauuaaa uacucguauu gcu              53


<210>  47
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.280604 guide nucleic acid

<400>  47
guugcaacuc acgcgcguau guggcuugaa gguauuaaau acucguauug cu               52


<210>  48
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.281060 guide nucleic acid

<400>  48
guugcaauuc auaucuccgg guggauugaa gguauuaaau acucguauug cu               52


<210>  49
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.284933 guide nucleic acid

<400>  49
guugcagcgu gcgcgagcgu guggcuugaa gguauuaaau acucguauug cu               52


<210>  50
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.287908 guide nucleic acid

<400>  50
guugcaacuc gcacgugaau gcgacuugaa gguauuaaau acucguauug cu               52


<210>  51
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.288518 guide nucleic acid

<400>  51
gaugcaacuc guguguaugu gcgaguugaa gguauuaaau acucguauug cu               52


<210>  52
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.293891 guide nucleic acid

<400>  52
gacgcaacuc gcgcgcgggc auguauugag gguauuaaau acucguauug cu               52


<210>  53
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.294270 guide nucleic acid

<400>  53
gaugcaucug acacagcugg gugaguugaa gguauuaaau acucguauug cu               52


<210>  54
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.294491 guide nucleic acid

<400>  54
guugcaacac auguaugugg gugaguugaa gguauuaaau acucguauug cu               52


<210>  55
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295047 guide nucleic acid

<400>  55
guugcagcgu gcgcgagcgu guggcuugaa gguauuaaau acucguauug cu               52


<210>  56
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.299588 guide nucleic acid

<400>  56
guugcaauuu guauacgagu gugacuugaa gguauuaaau acucguauug cu               52


<210>  57
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.277328 guide nucleic acid

<400>  57
gcugcaacac gcgcggguac gcggguugaa gguauuaaau acucguauug cu               52


<210>  58
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.297894 guide nucleic acid

<400>  58
guugcaacuc gcacguuggc acugauugaa gguauuaaau acucguauug cu               52


<210>  59
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.291449 guide nucleic acid

<400>  59
gcuguagccc ugcucaaauu guagggcgca ugcagguauu aaauacucgu auug             54


<210>  60
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.297599 guide nucleic acid

<400>  60
guuguagucg accugaaucu guggggugcu uacagguauu aaauacucgu auugcu           56


<210>  61
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286588 guide nucleic acid

<400>  61
gguguaugua accgcaauuu gaagggugca uacagguauu aaauacucgu auugcu           56


<210>  62
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286910 guide nucleic acid

<400>  62
guuggaaucg accuuaauuu gaggugugcu uacagguauu aaauacucgu auugcu           56


<210>  63
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286910 guide nucleic acid

<400>  63
gcugaaagag cagagaauuu guugugugca uacagguauu aaauacucgu auugcu           56


<210>  64
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.293576 guide nucleic acid

<400>  64
guuggagucg gcuugaaucu gcggggugcu uacagguauu aaauacucgu auugcu           56


<210>  65
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.294537 guide nucleic acid

<400>  65
guuggaaucg accuuaauuu gaggugugcu uacagguauu aaauacucgu auugcu           56


<210>  66
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.298538 guide nucleic acid

<400>  66
guuguaagag acccgaauuu uagcugugua uacagguauu aaauacucgu auugcu           56


<210>  67
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19924 guide nucleic acid

<400>  67
guugugaaug caggcauuuu ugaugguaaa uccaacuauu aaauacucgu auugcu           56


<210>  68
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952 guide nucleic acid

<400>  68
acugucagac aaugcaaaau gugugguaca uccaacuauu aaauacucgu auugcu           56


<210>  69
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.274559 guide nucleic acid

<400>  69
gcugucagua guaguaaaaa uggggguaca uccaacuauu aaauacucgu auugcu           56


<210>  70
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251 guide nucleic acid

<400>  70
acugucagua caugcaaaaa ugaggguaca uccaacuauu aaauacucgu auugcu           56


<210>  71
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.288480 guide nucleic acid

<400>  71
acugucagac aaugcaaaau gagugguaca uccaacuauu aaauacucgu auugcu           56


<210>  72
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.288668 guide nucleic acid

<400>  72
gcuguuagaa cauacaaaau gaaagguaca uccaacuauu aaauacucgu auugcu           56


<210>  73
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.289206 guide nucleic acid

<400>  73
gcugcauguc auggcaaaag gaaagguaca uccaacuauu aaauacucgu auugcu           56


<210>  74
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.290598 guide nucleic acid

<400>  74
gcugucagac accuaaaaaa ugaggguaca uccaacuauu aaauacucgu auugcu           56


<210>  75
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.290816 guide nucleic acid

<400>  75
gcugugaguc acaguaaaaa ugaagguaua uccaacuauu aaauacucgu auugcu           56


<210>  76
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295071 guide nucleic acid

<400>  76
acugucagua caugcaaaaa ugaggguaca uccaacuauu aaauacucgu auugcu           56


<210>  77
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295231 guide nucleic acid

<400>  77
gcugugaguc acaguaaaaa ugaagguaua uccaacuauu aaauacucgu auugcu           56


<210>  78
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.292139 guide nucleic acid

<400>  78
gauguauaug cuaugauuuu guaugguaca uccaacuauu aaauacucgu auugcu           56


<210>  79
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.279423 guide nucleic acid

<400>  79
gcugucagua guaguaaaaa uggggguaca uccaacuauu aaauacucgu auugcu           56


<210>  80
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.20054 guide nucleic acid

<400>  80
guugagcucu gcauuacgca gaugaaugac gaguauuaaa uacucguauu gcu              53


<210>  81
<211>  131
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.282673 guide nucleic acid

<400>  81
auaagggcgg cucagcgucc uaaagucgag aaaguaugcg uaaacuucuu ucauagaauu       60

gcagauacuc ucggcaaggu aaaaacccua caaauuuaau ccuuguaggc gacuuauauu      120

uguguauauu u                                                           131


<210>  82
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.282952 guide nucleic acid

<400>  82
guugcaaucu gcguacaggc guaagaugug aguauuaaau acucguauug cu               52


<210>  83
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.283262 guide nucleic acid

<400>  83
gaucauaucu gcuuguaugg guaugcugcg aguauuaaau acucguauug cu               52


<210>  84
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.284833 guide nucleic acid

<400>  84
guugcaacuu acgcauaggu guaaaauacg aguauuaaau acucguauug cu               52


<210>  85
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.287700 guide nucleic acid

<400>  85
gauuauaucu gcuuguaugg guauacugcg aguauuaaau acucguauug cu               52


<210>  86
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.291507 guide nucleic acid

<400>  86
guugcaacuu acgcauaggu guaaaauacg aguauuaaau acucguauug cu               52


<210>  87
<211>  58
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.293410 guide nucleic acid

<400>  87
ucagcucaca accuacauau gcauacaaga uauaucguua uuaaauacuc guauugcu         58


<210>  88
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295105 guide nucleic acid

<400>  88
gaucauaucu gcuuguaugg guaugcugcg aguauuaaau acucguauug cu               52


<210>  89
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295187 guide nucleic acid

<400>  89
gauauaucuu guaugcauau guagguugug aguauuaaau acucguauug cu               52


<210>  90
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295929 guide nucleic acid

<400>  90
guugcaauga acguaugugc augaggugug aguauuaaau acucguauug cu               52


<210>  91
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.298706 guide nucleic acid

<400>  91
ggggcgucuu cccgucccua aaucgagaua gcagccauuu uucuucauuu uugaagacgg       60

ucuugcacuc gaaaagguca ag                                                82


<210>  92
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.280604 guide nucleic acid

<400>  92
ggggcgacuu cccgccccaa aaucgagaaa gugacuguca gacuuugcua ugcaaagcaa       60

guaauacacu cgagaaggua aaga                                              84


<210>  93
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.281060 guide nucleic acid

<400>  93
agggcgacuu cccguccuaa aaucgagaaa gugacaauuc agucucgcau uucgagcauu       60

guaauacacu cgaaaagguu aag                                               83


<210>  94
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.284933 guide nucleic acid

<400>  94
ggggcgacuu cccgucccaa aaucgagaaa guggucguaa gucucgaucg gaucgaagca       60

gacaauacac ucgaaaaggu uaagu                                             85


<210>  95
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.287908 guide nucleic acid

<400>  95
ggggcgacuu cccgucccua aaucgagaaa guggcgguaa gacuucgguc uucgaagcgc       60

gcaauacacu cgaaaagguu aa                                                82


<210>  96
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.288518 guide nucleic acid

<400>  96
ggggcgacuu cccgucccaa aaucgagaaa gugacaguaa uucuuuguuu uacagagguu       60

guaauacacu cgauaagguu aag                                               83


<210>  97
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.293891 guide nucleic acid

<400>  97
ggggcgaccu cccgucccaa aaucgagaaa guggccguca gacuucucgc ugagaagcac       60

gcaauacacu cgaaaaggua aag                                               83


<210>  98
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.294270 guide nucleic acid

<400>  98
agggcgacuu cccguccuga aaucgagaaa gugacaagga aagcgcaauu uugcgccguu       60

guaauacacu cgagaagguc aag                                               83


<210>  99
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.294491 guide nucleic acid

<400>  99
agggcgacuu cccguccuaa aaucgagaua gugacaaguc agucucuuau gaggagcauu       60

guaauacacu cgagaagguc aag                                               83


<210>  100
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295047 guide nucleic acid

<400>  100
ggggcgacuu cccgucccaa aaucgagaaa guggucguaa gucucgaucg gaucgaagca       60

gacaauacac ucgaaaaggu uaagu                                             85


<210>  101
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.299588 guide nucleic acid

<400>  101
agggcgacuu cacguccuca aaucgagaaa gugagcguaa gacuuggcuu cugucaagcg       60

guuaauacac ucgagaaggu uaa                                               83


<210>  102
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.277328 guide nucleic acid

<400>  102
ggggcgacuu cccgucccga aaucgagaaa gugaccguca gacucugcuu ugcagagcag       60

guaauacacu cgagaaggua aag                                               83


<210>  103
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.297894 guide nucleic acid

<400>  103
ggggcgucuu cccgucccua aaucgagaua gcagccauuu uucuucauuu uuugaagacg       60

gucuugcacu cgaaaagguc aag                                               83


<210>  104
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.291449 guide nucleic acid

<400>  104
cacgcuagcu gaaaagcaac cgcguacacg cggacgaacg gccgaccugc ucggccugaa       60

gguugagaag guuauguaua agaggagaaa aucccccuuc auaaucgcuc accaagcucc      120

caauuuacau auuuu                                                       135


<210>  105
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.291449 guide nucleic acid

<400>  105
cggccgaccu gcucggccug aagguugaga agguuaugua uaagaggaga aaaucccccu       60

ucauaaucgc ucaccaagcu cccaauuuac auauuuu                                97


<210>  106
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.297599 guide nucleic acid

<400>  106
uauugcgcua gccauaaugg caaucgcgua caggcaacug aaggccgacc uguacggccu       60

uaagguugag aaggcacaug uaaguggaaa aaugcuuucc cguuguguuc gcucaccaag      120

cacacacguu uuuuu                                                       135


<210>  107
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.297599 guide nucleic acid

<400>  107
gaaggccgac cuguacggcc uuaagguuga gaaggcacau guaaguggaa aaaugcuuuc       60

ccguuguguu cgcucaccaa gcacacacgu uuuuuu                                 96


<210>  108
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286588 guide nucleic acid

<400>  108
aggucgccgu uuacguugcg ucacaagggc gcgcgggcga ccgaaggccg aucuguacgg       60

ccugcagguu gagaaggcac auauuagagg aaaauugcuu cccuuugugu ucgcucaccg      120

aguauuccuu guuuuuu                                                     137


<210>  109
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286588 guide nucleic acid

<400>  109
aucuguacgg ccugcagguu gagaaggcac auauuagagg aaaauugcuu cccuuugugu       60

ucgcucaccg aguauuccuu guuuuuu                                           87


<210>  110
<211>  138
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286910 guide nucleic acid

<400>  110
caauguuucg cuaaccuuua agguaaucgc gggcaggcga cugaaggccg accuguacgg       60

ccuuaaggcu gagaaggcac auguaagugg aaaaaugcuu ucccguugug uucgcucacc      120

aagcacauuu guuuuuuu                                                    138


<210>  111
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286910 guide nucleic acid

<400>  111
gaaggccgac cuguacggcc uuaaggcuga gaaggcacau guaaguggaa aaaugcuuuc       60

ccguuguguu cgcucaccaa gcacauuugu uuuuuu                                 96


<210>  112
<211>  136
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.292335 guide nucleic acid

<400>  112
aggccguuau caacguuucg cggaagagcg gacgaacggc ugaaggccga ccuguacggc       60

cuaaagguug agaaggcaca uguaagagga aaaucgcuuc ccuuuguguu cgcucaccgg      120

guacacgcgu uuuuuu                                                      136


<210>  113
<211>  93
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.292335 guide nucleic acid

<400>  113
aggccgaccu guacggccua aagguugaga aggcacaugu aagaggaaaa ucgcuucccu       60

uuguguucgc ucaccgggua cacgcguuuu uuu                                    93


<210>  114
<211>  142
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.293576 guide nucleic acid

<400>  114
ucguaaaugu ugcgcuagcc auaauggcaa ucgcguacag gcaacugaag gccgaccugu       60

acggccuuaa gguugagaag gcacauguca guggaaaaau gcuuucccuu uguguucgcu      120

caccaagcac acgcgguuuu uu                                               142


<210>  115
<211>  95
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.293576 guide nucleic acid

<400>  115
aaggccgacc uguacggccu uaagguugag aaggcacaug ucaguggaaa aaugcuuucc       60

cuuuguguuc gcucaccaag cacacgcggu uuuuu                                  95


<210>  116
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.294537 guide nucleic acid

<400>  116
aauguuucgc uaaccuuuaa gguaaucgcg ggcaggcgac ugaaggccga ccuguacggc       60

cuuaaggcug agaaggcaca uguaagugga aaaaugcuuu cccguugugu ucgcucacca      120

agcacauuug uuuuuuu                                                     137


<210>  117
<211>  95
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.294537 guide nucleic acid

<400>  117
aaggccgacc uguacggccu uaaggcugag aaggcacaug uaaguggaaa aaugcuuucc       60

cguuguguuc gcucaccaag cacauuuguu uuuuu                                  95


<210>  118
<211>  148
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.298538 guide nucleic acid

<400>  118
ggucguugua aaacguaacg cuagccuuau ggcaaucgcg aacgaacgac ugaaggccga       60

ccuguacggc cugaaggaug agaaggcaca uauuagagga aaaaaauggu ucccuuugug      120

accgcucacc aaacacaugu uuauuuuu                                         148


<210>  119
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.298538 guide nucleic acid

<400>  119
aaggccgacc uguacggccu gaaggaugag aaggcacaua uuagaggaaa aaaaugguuc       60

ccuuugugac cgcucaccaa acacauguuu auuuuu                                 96


<210>  120
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19924 guide nucleic acid

<400>  120
augaauagga uucguccuau ggggcaguug guugcccuua gccugaggca uuuauugcac       60

ucgggaagua ccauuucuca                                                   80


<210>  121
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.274559 guide nucleic acid

<400>  121
augaauagga uuuauccuau ggggcaguug guugcccuua gccugaggca uuuaaugcac       60

ucgggaagua ccuuuucuca                                                   80


<210>  122
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251 guide nucleic acid

<400>  122
aagaauagga uucauccuau ggggcaguug guugcccuua gccugaggaa uuuaauucac       60

ucgggaagua ccuuucucau                                                   80


<210>  123
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.288668 guide nucleic acid

<400>  123
auggauagga uucguccuau ggggcaguug ggaccaugua augcccuuag ccugaggaau       60

ucauuucacu cgggaaguau                                                   80


<210>  124
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.290816 guide nucleic acid

<400>  124
augaauagga uuuauccuau ggggcaguug gaugcccuua gccugaggca uuuauugcac       60

ucgggaagua ccuuuucuca                                                   80


<210>  125
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.292139 guide nucleic acid

<400>  125
uauuuucuaa ugggguuguu ggaaagagcu uuuacugaaa uuuguaaagg ugcccugaac       60

uugagaauug aaaaauuacu cgag                                              84


<210>  126
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.292139 guide nucleic acid

<400>  126
augggguugu uggaaagagc uuuuacugaa auuuguaaag gugcccugaa cuugagaauu       60

gaaaaauuac ucgag                                                        75


<210>  127
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.279423 guide nucleic acid

<400>  127
augaauagga uuuauccuau ggggcaguug guugcccuua gccugaggca uuuaaugcac       60

ucgggaagua ccuuuucuca                                                   80


<210>  128
<211>  122
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.20054 guide nucleic acid

<400>  128
uucgggcggc ucggcguccg uaaaucgaga aagagcuugu aauuccugau ucuaucaggu       60

gaagcaacac ucgguaaggu auaacaauac acauguauaa uccguguauu uaaguucauu      120

uu                                                                     122


<210>  129
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.20054 guide nucleic acid

<400>  129
uucgggcggc ucggcguccg uaaaucgaga aagagcuugu aauuccugau ucuaucaggu       60

gaagcaacac ucgguaaggu auaac                                             85


<210>  130
<211>  131
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.282673 guide nucleic acid

<400>  130
auaagggcgg cucagcgucc uaaagucgag aaaguaugcg uaaacuucuu ucauagaauu       60

gcagauacuc ucggcaaggu aaaaacccua caaauuuaau ccuuguaggc gacuuauauu      120

uguguauauu u                                                           131


<210>  131
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.282673 guide nucleic acid

<400>  131
auaagggcgg cucagcgucc uaaagucgag aaaguaugcg uaaacuucuu ucauagaauu       60

gcagauacuc ucggcaaggu aaaa                                              84


<210>  132
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.282952 guide nucleic acid

<400>  132
auucuuuccu cggaaagugg uagauacucu cgguaaggua aacuguguau gaacaguuug       60

aaauccugca cauaaaaucc gugcaggcau cuuauaguuu ugugcaucuu u               111


<210>  133
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.282952 guide nucleic acid

<400>  133
auucuuuccu cggaaagugg uagauacucu cgguaaggua aacuguguau gaacaguuug       60

aaauccugca cauaaaaucc gugcaggcau c                                      91


<210>  134
<211>  129
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.283262 guide nucleic acid

<400>  134
uucgggcggc ucggcguccg uaaaccgaga aaguauaugu aagucugaau uuauucagcg       60

uuagauacac ucgguaaggu ucaaacaaua cauauucaau ccauguauuc aguauauuug      120

uacauuuuu                                                              129


<210>  135
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.283262 guide nucleic acid

<400>  135
uucgggcggc ucggcguccg uaaaccgaga aaguauaugu aagucugaau uuauucagcg       60

uuagauacac ucgguaaggu ucaaac                                            86


<210>  136
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.284833 guide nucleic acid

<400>  136
uucagggcga cucggcgucc uaaaaucgag aaaguguaca uaaauuuuua acaaaauacg       60

guaaauacuc ucgguaaggu uuuaacgugc acauaauaau ccgugcaaca ggguuacacu      120

uuugugcaau uuu                                                         133


<210>  137
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.284833 guide nucleic acid

<400>  137
uucagggcga cucggcgucc uaaaaucgag aaaguguaca uaaauuuuua acaaaauacg       60

guaaauacuc ucgguaaggu uuuaac                                            86


<210>  138
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.287700 guide nucleic acid

<400>  138
uucgggcggc ucggcguccg uaaaccgaga aaguauaugu aagucugaau uuauucagcg       60

uuagauacac ucgguaaggu uuaaac                                            86


<210>  139
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.291507 guide nucleic acid

<400>  139
uucagggcga cucggcgucc uaaaaucgag aaaguguaca uaaguuuuua acaaaauacg       60

guaaauacuc ucgguaaggu uuuaacgugc acauaauaau ccgugcaaca ggguuacacu      120

uuugugcaau uuu                                                         133


<210>  140
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.291507 guide nucleic acid

<400>  140
uucagggcga cucggcgucc uaaaaucgag aaaguguaca uaaguuuuua acaaaauacg       60

guaaauacuc ucgguaaggu uuuaacg                                           87


<210>  141
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.293410 guide nucleic acid

<400>  141
uauuaagggc ggcucagcgu ccuuaagucg agaaaguaua cauaaauuuc uuauauagaa       60

uaguagauac ucucggcaag guauaaaccc uacaaauuua auccuuguag gcaacuuaua      120

uuuguauuua uuu                                                         133


<210>  142
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.293410 guide nucleic acid

<400>  142
uauuaagggc ggcucagcgu ccuuaagucg agaaaguaua cauaaauuuc uuauauagaa       60

uaguagauac ucucggcaag guauaaacc                                         89


<210>  143
<211>  130
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295105 guide nucleic acid

<400>  143
uuucgggcgg cucggcgucc guaaaccgag aaaguauaug uaagucugaa uuuauucagc       60

guuagauaca cucgguaagg uucaaacaau acauauucaa uccauguauu caguauauuu      120

guacauuuuu                                                             130


<210>  144
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295105 guide nucleic acid

<400>  144
uuucgggcgg cucggcgucc guaaaccgag aaaguauaug uaagucugaa uuuauucagc       60

guuagauaca cucgguaagg uucaaac                                           87


<210>  145
<211>  134
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295187 guide nucleic acid

<400>  145
auauuaaggg cggcucagcg uccuuaaguc gagaaaguau acauaaauuu cuuauauaga       60

auaguagaua cucucggcaa gguauaaacc cuacaaauuu aauccuugua ggcaacuuau      120

auuuguauuu auuu                                                        134


<210>  146
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295187 guide nucleic acid

<400>  146
auauuaaggg cggcucagcg uccuuaaguc gagaaaguau acauaaauuu cuuauauaga       60

auaguagaua cucucggcaa gguauaaac                                         89


<210>  147
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295929 guide nucleic acid

<400>  147
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc cacaaugaaa auccugugga caccguauaa      120

uaugugcaug uuu                                                         133


<210>  148
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.295929 guide nucleic acid

<400>  148
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc                                        90


<210>  149
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19924 guide nucleic acid

<400>  149
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacua uuaaauacuc guauugcu                               98


<210>  150
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.274559 guide nucleic acid

<400>  150
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacu auuaaauacu cguauugcu                              99


<210>  151
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251 guide nucleic acid

<400>  151
auggggcagu ugguugcccu uagccugagg aauuuaauuc acucgggaag uaccuuucuc       60

augaaauggu acauccaacu auuaaauacu cguauugcu                              99


<210>  152
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.290816 guide nucleic acid

<400>  152
auggggcagu uggaugcccu uagccugagg cauuuauugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacu auuaaauacu cguauugcu                              99


<210>  153
<211>  136
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasM.292139 guide nucleic acid

<400>  153
ttattagaaa tgaaatattt tctaatgggg ttgttggaaa gagcttttac tgaaatttgt       60

aaaggtgccc tgaacttgag aattgaaaaa ttactcgagg aaatggtaca tccaactatt      120

aaatactcgt attgct                                                      136


<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169

<400>  169
000

<210>  170
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  170

Gly Ser Gly Gly Ser 
1               5   


<210>  171
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  171

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  172
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  172

Gly Gly Gly Ser 
1               


<210>  173
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  173

Gly Gly Ser Gly 
1               


<210>  174
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  174

Gly Gly Ser Gly Gly 
1               5   


<210>  175
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  175

Gly Ser Gly Ser Gly 
1               5   


<210>  176
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  176

Gly Ser Gly Gly Gly 
1               5   


<210>  177
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  177

Gly Gly Gly Ser Gly 
1               5   


<210>  178
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  178

Gly Ser Ser Ser Gly 
1               5   


<210>  179

<400>  179
000

<210>  180
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  180
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguuc                               98


<210>  181
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  181
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaaccc cggguaagcc ugucugcu                               98


<210>  182
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  182
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaaccg ugcuguuucc uccccacg                               98


<210>  183
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  183
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacgu gccuuaguuu cuucaucu                               98


<210>  184
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  184
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacgg gggcgggggg gagaaaaa                               98


<210>  185
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  185
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacgc gcccuccgau cuggggug                               98


<210>  186
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Engineered guide nucleic acid

<400>  186
tggggcagtt ggttgccctt agcctgaggc atttattgca ctcgggaagt accatttctc       60

agaaatggta catccaac                                                     78


<210>  187
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS Sequence


<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  187

Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Arg 
1               5                   10                  15      


Lys Arg 
        


<210>  188
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS Sequence


<220>
<221>  misc_feature
<222>  (3)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  188

Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys 
1               5                   10                  15      


Arg Lys Arg 
            


<210>  189
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS Sequence


<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa = Lysine/ Arginine

<400>  189

Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Arg 
1               5                   10                  15      


Xaa Xaa 
        


<210>  190
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS Sequence


<220>
<221>  misc_feature
<222>  (3)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = Lysine/ Arginine

<400>  190

Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys 
1               5                   10                  15      


Arg Xaa Xaa 
            


<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000

<210>  200
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosomal escape protein


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is independently selected from lysine, histidine, and 
       arginine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is independently selected from lysine, histidine, and 
       arginine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is independently selected from lysine, histidine, and 
       arginine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is independently selected from lysine, histidine, and 
       arginine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is independently selected from lysine, histidine, and 
       arginine

<400>  200

Gly Leu Phe Xaa Ala Leu Leu Xaa Leu Leu Xaa Ser Leu Trp Xaa Leu 
1               5                   10                  15      


Leu Leu Xaa Ala 
            20  


<210>  201
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endosomal escape protein

<400>  201

Gly Leu Phe His Ala Leu Leu His Leu Leu His Ser Leu Trp His Leu 
1               5                   10                  15      


Leu Leu His Ala 
            20  


<210>  202
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.19498

<400>  202

Leu His Glu Thr Glu Lys Ser Leu Lys Phe Ala Glu Lys Tyr Ile Ala 
1               5                   10                  15      


Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Glu Gly 
            20                  25                  30          


Leu Ser Asp Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
        35                  40                  45              


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
    50                  55                  60                  


Leu Asp Glu His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
65                  70                  75                  80  


Leu Ser Leu Gln Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Val Asp 
                85                  90                  95      


Asp Ala Ile Ile Val Glu Leu Thr Arg Lys Leu Ala Val Ala Glu Lys 
            100                 105                 110         


Glu Met Thr Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu Met 
        115                 120                 125             


Ser Thr Asn Thr Leu Ala Tyr Asn Phe Ala Lys Glu Ile Glu Thr Lys 
    130                 135                 140                 


Ile Phe Gly Gln Ile Leu Ala Cys Leu Glu Asn Asn Ala His Ala Leu 
145                 150                 155                 160 


Phe Val Asp Asp Ser Pro Asn Val Arg Arg Gly Glu Arg Ala Ile Arg 
                165                 170                 175     


Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Arg Ser Ile 
            180                 185                 190         


Lys Ile Glu Ala Asp Gly Gly Glu Phe Tyr Leu Arg Trp Tyr Asn Gly 
        195                 200                 205             


Leu Arg Phe Leu Leu Thr Phe Gly Lys Asp Arg Ser Asn Asn Arg Leu 
    210                 215                 220                 


Ile Val Lys Arg Cys Met Lys Met Asp Glu Val Phe Glu Gly Glu Tyr 
225                 230                 235                 240 


Lys Leu Cys Asn Ser Ser Ile Gln Leu Ala Lys Arg Asp Gly Lys Pro 
                245                 250                 255     


Lys Leu Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu His Val Glu 
            260                 265                 270         


Leu Asn Lys Asn Ile Val Val Gly Val Asp Leu Gly Val Asn Val Pro 
        275                 280                 285             


Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly Asp 
    290                 295                 300                 


Arg Glu His Phe Leu Asn Thr Arg Met Thr Phe Gln Lys Arg Tyr Lys 
305                 310                 315                 320 


Ser Leu Gln Arg Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Thr Lys 
                325                 330                 335     


Lys Leu Glu Pro Leu Glu Arg Leu Arg Asp Ala Glu Arg Asn Trp Val 
            340                 345                 350         


His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asn Phe Ala Val 
        355                 360                 365             


Gln Ala Arg Ala Ala Thr Ile Asn Ile Glu Asp Leu Ser Gly Phe Gly 
    370                 375                 380                 


Lys Asp Asn Asp Gly Asn Ala Asp Glu Lys Lys Glu Phe Val Leu Arg 
385                 390                 395                 400 


Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Thr Tyr Lys Ala Ser 
                405                 410                 415     


Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Asp Tyr Thr Ser Lys 
            420                 425                 430         


Thr Cys Ser Trp Cys Gly Gln Gln Gly Phe Arg Glu Gly Val Thr Phe 
        435                 440                 445             


Ile Cys Glu Asn Pro Glu Cys Lys Gln His Gly Glu Lys Ile His Ala 
    450                 455                 460                 


Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile Lys 
465                 470                 475                 480 


Lys Asn Glu 
            


<210>  203
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.19548

<400>  203

Met Ala Glu Thr Lys Arg Leu Gln Lys Val Ala Lys Phe Gln Ile Val 
1               5                   10                  15      


Lys Pro Val Asn Met Ser Trp Asp Glu Leu Gly Arg Met Leu Arg Asp 
            20                  25                  30          


Val Arg Tyr Arg Leu Ser Arg Leu Ala Asn Met Ala Val Ser Glu Thr 
        35                  40                  45              


Tyr Gln Asn Leu His Gln Arg Tyr Arg Leu Lys Asn Gln Asp Ala Pro 
    50                  55                  60                  


Lys Ser Leu Lys Ile Gly Gln Leu Ser Arg Asn Leu Arg Lys Ile Leu 
65                  70                  75                  80  


Arg Glu Glu Gly Val Glu Glu Glu Asn Leu Ser Lys Tyr Ser Lys Thr 
                85                  90                  95      


Cys Val Leu Pro Asp Thr Ile Thr Gly Ala Phe Ser Arg Tyr Lys Leu 
            100                 105                 110         


Ser Ser Ile Asp Trp Arg Lys Val Leu Thr Gly Lys Ile Ser Val Pro 
        115                 120                 125             


Asn Tyr Lys Thr Asn Leu Ser Ile Pro Ile Arg Cys Asp Lys Pro His 
    130                 135                 140                 


Gln Arg Arg Leu Glu Leu Thr Glu Thr Gly Glu Ile Glu Ala Asp Leu 
145                 150                 155                 160 


Met Ile Cys Asn Lys Pro Tyr Pro Arg Val Leu Leu Ser Thr Arg Thr 
                165                 170                 175     


Ile Ser Asp Gly Gln Arg Thr Val Leu Glu Arg Leu Val Ser Asn Lys 
            180                 185                 190         


Thr Asn Phe Leu Pro Gly Tyr Arg His Arg Phe Phe Glu Val Lys Glu 
        195                 200                 205             


Lys Lys Gly Lys Trp Glu Leu Ser Val Thr Tyr Asp Phe Pro Lys Ala 
    210                 215                 220                 


Glu Ala Thr Arg Leu His Pro Asp Ile Ile Val Gly Val Asp Leu Gly 
225                 230                 235                 240 


Trp Ser Val Pro Leu Tyr Ala Ala Ile Asn Asn Gly Tyr Ala Arg Ile 
                245                 250                 255     


Gly Tyr Arg Lys Phe Glu Pro Leu Ala Lys Arg Ile Lys His Leu Gln 
            260                 265                 270         


Lys Gln Ile Lys Gly Arg Arg Phe Ser Thr Gln Lys Gly Gly Val Lys 
        275                 280                 285             


Asp Leu Ala Gln Pro Thr Ala Arg Ala Gly His Gly Arg Lys Arg Ile 
    290                 295                 300                 


Leu Lys Pro Ile Glu Lys Leu Glu Tyr Lys Ile Asp Asn Ala Tyr Thr 
305                 310                 315                 320 


Thr Leu Asn His Gln Leu Ser His Cys Val Val Glu Phe Ala Lys Asn 
                325                 330                 335     


Asn Gly Ala Gly Leu Ile Gln Ile Glu Asn Leu Glu Gly Leu Lys Asp 
            340                 345                 350         


Asp Leu Ser Gly Thr Phe Ile Gly Gln Asn Trp Arg Tyr Asn Gln Leu 
        355                 360                 365             


Gln Asn Phe Ile Lys Tyr Lys Ala Asp Glu Ala Gly Ile Lys Val His 
    370                 375                 380                 


Pro Val Asn Pro Cys Tyr Thr Ser Arg Arg Cys Ser His Cys Gly Phe 
385                 390                 395                 400 


Ile His Ile Ser Phe Asp Arg Glu Tyr Arg Asp Lys Asn Arg Lys Asn 
                405                 410                 415     


Gly Lys Ala Thr Met Phe Glu Cys Pro Lys Gly Cys Lys Pro Leu Asn 
            420                 425                 430         


Ala Asp Tyr Asn Ala Ala Lys Asn Leu Ala Thr Phe Asp Ile Glu Glu 
        435                 440                 445             


Lys Ile Arg Leu Gln Cys Lys Gln Gln Ser Ile Glu Tyr Lys Glu Leu 
    450                 455                 460                 


Pro Lys Asp 
465         


<210>  204
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.19910

<400>  204

Met Pro Gly Thr Glu Lys Arg Leu Gln Lys Val Ala Thr Phe Glu Ile 
1               5                   10                  15      


Val Lys Pro Val Asn Met Ser Trp Pro Glu Phe Gly Lys Met Leu Arg 
            20                  25                  30          


Asp Val Arg Tyr Arg Tyr Trp Arg Leu Ala Asn Met Ala Val Cys Glu 
        35                  40                  45              


Asn Tyr Met Arg Phe Tyr Gln Trp Arg Thr Gln Gln Thr Asp Ala Asn 
    50                  55                  60                  


Asp Arg Tyr Lys Val Lys Thr Leu Asn Arg Ile Leu Arg Lys Met Leu 
65                  70                  75                  80  


Ile Glu Glu Lys Asn Ala Asp Glu Lys Glu Leu Ser Arg Tyr Ser Arg 
                85                  90                  95      


Asp Gly Ala Val Ser Gly Tyr Ile Cys Gly Ala Phe Glu Lys Thr Lys 
            100                 105                 110         


Leu Ser Ala Val Lys Ser Ser Ser Lys Trp Lys Lys Val Ile Ala Gly 
        115                 120                 125             


Lys Glu Ser Leu Pro Leu Phe Lys Lys Asp Leu Ala Ile Pro Ile Asn 
    130                 135                 140                 


Cys Ser Asp His Gln Pro Arg Leu Ile Glu Arg Thr Gln Ser Gly Glu 
145                 150                 155                 160 


Tyr Glu Val Asp Leu Arg Ile Cys Gln Gln Pro Tyr Pro Arg Val Leu 
                165                 170                 175     


Leu Ser Thr Ala Lys Ile Ser Asp Gly Gln Lys Ala Ile Leu Glu Arg 
            180                 185                 190         


Leu Val Ser Asn Glu Thr Asn Ser Leu Pro Gly Tyr Arg His Arg Phe 
        195                 200                 205             


Phe Glu Ile Lys Glu Lys Arg Asn Lys Trp Tyr Leu Ser Val Ser Tyr 
    210                 215                 220                 


Asp Phe Pro Lys Ile Asp Ala Thr Arg Leu His Pro Asn Ile Ile Val 
225                 230                 235                 240 


Gly Val Asp Leu Gly Trp Ser Val Pro Leu Tyr Ala Ala Ile Ser Asn 
                245                 250                 255     


Gly Tyr Ala Arg Ile Gly Tyr Arg Lys Leu Lys Ala Leu Gly Asp Arg 
            260                 265                 270         


Ile Lys Ala Leu Gln Arg Gln Thr Ile Ala Arg Arg Arg Ser Ile Gln 
        275                 280                 285             


Arg Thr Gly Glu Gln Asp Leu Ser Ala Pro Thr Ala Arg Ser Gly His 
    290                 295                 300                 


Gly Arg Lys Arg Ile Leu His Pro Ile Glu Lys Leu Glu Gly Lys Ile 
305                 310                 315                 320 


Asp Asn Ala Tyr Lys Thr Leu Asn His Gln Leu Ser His Cys Val Ile 
                325                 330                 335     


Glu Phe Ala Lys Asn His Gly Ala Gly Leu Ile Gln Val Glu Asn Leu 
            340                 345                 350         


Lys Gly Leu Ala Glu Glu Leu Ser Gly Thr Phe Ile Gly Gln Asn Trp 
        355                 360                 365             


Arg Tyr Asn Gln Leu Gln Glu Phe Ile Lys Tyr Lys Ala Lys Glu Ala 
    370                 375                 380                 


Gly Ile Glu Val Lys Glu Val Asn Pro Cys Tyr Thr Ser Arg Arg Cys 
385                 390                 395                 400 


Ser Glu Cys Gly Phe Ile His Lys Glu Phe Thr Phe Glu Tyr Arg Gln 
                405                 410                 415     


Ala Asn Lys Lys Thr Asp Lys Ala Thr Met Phe Glu Cys Pro Lys Cys 
            420                 425                 430         


Gly Tyr Lys Ala Ile Ala Asp Tyr Asn Ala Ala Arg Asn Leu Ala Asn 
        435                 440                 445             


Pro Asp Ile Ala Glu Lys Ile Arg Leu Gln Cys Lys Glu Gln Gly Ile 
    450                 455                 460                 


Glu Tyr Lys Glu Leu Pro Lys Asp 
465                 470         


<210>  205
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.19948

<400>  205

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu His Phe Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Glu Lys Gln Lys Glu Gln Arg Gln Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Leu Lys His Ala Asp Tyr 
    50                  55                  60                  


Leu Ser Leu Gln Arg Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Asp Glu Leu Ile Thr Glu Leu Ser Arg Lys Leu Ser Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ala Thr Ser Thr Leu Ala Tyr Asn Phe Ala Lys Glu Met Glu Thr 
        115                 120                 125             


Glu Ile Phe Gly Gln Ile Leu Ala Cys Leu Glu Asn Asn Ala His Ala 
    130                 135                 140                 


Val Phe Val Asp Asp Ser Leu Ser Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Lys Asn 
                165                 170                 175     


Ile Lys Ile Glu Thr Lys Asp Cys Glu Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Ile Arg Phe Arg Leu His Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Gln Arg Cys Leu Lys Leu Asp Asp Asn Phe Glu Ser Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Leu Asp Lys Arg Asp Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Asn Ile Val Val Gly Val Asp Leu Gly Leu Asn Tyr 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ser Thr Glu Glu Arg Lys Tyr Ile Gly 
        275                 280                 285             


Asp Arg Asp His Phe Leu Lys Ile Arg Met Gln Phe Gln Ser Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu Arg Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Asp Val Val Asn Phe Ala 
            340                 345                 350         


Val Gln Thr His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Lys Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Ser Met Ile Glu Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Gln Gly Asp Arg Lys Ser Thr Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys His Tyr Gly Glu Ser Ile His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Val 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  206
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.265291

<400>  206

Met Ser Lys Ile Thr Arg Lys Ile Glu Ile Ile Pro Asp Ile Asp Gly 
1               5                   10                  15      


Ile Thr His Glu Glu Ser Asn Lys Lys Cys Tyr Asn Thr Phe Tyr Lys 
            20                  25                  30          


Phe Asp Arg Lys Leu Tyr Lys Val Ala Asn Leu Leu Val Ser Gln Leu 
        35                  40                  45              


Tyr Gly Leu Asp Asn Leu Leu Ser Leu Met Arg Leu Gln Asn Asp Glu 
    50                  55                  60                  


Tyr Val Lys Cys Gln Ser Lys Leu Ser Phe Lys Ser Ile Thr Asp Ala 
65                  70                  75                  80  


Thr Lys Glu Glu Ile Lys Lys Arg Met Gln Glu Ile Asp Ala Glu Leu 
                85                  90                  95      


Val Ser Met Lys Asn Asp Ile Ala Pro Lys His Pro Gln Thr Tyr Ser 
            100                 105                 110         


Tyr Arg Ala Val Thr Ser Ser Glu Tyr Ala Lys Asp Ile Pro Ser Asp 
        115                 120                 125             


Ile Leu Asn Asn Leu Lys Gln Asp Val Tyr Gln His Phe Asn Glu Asn 
    130                 135                 140                 


Lys Lys Glu Gln Ile Arg Gly Glu Arg Ser Leu Ala Thr Tyr Lys Lys 
145                 150                 155                 160 


Gly Met Pro Ile Pro Phe Ser Phe Glu Lys Arg His Val Ile Ile Cys 
                165                 170                 175     


Asp Gly Asp Asn Tyr Tyr Leu Pro Trp Phe Glu Asp Thr Arg Phe Arg 
            180                 185                 190         


Leu Asn Phe Gly Arg Asp Arg Ser Asn Asn Arg Ala Ile Ile Asp Asn 
        195                 200                 205             


Cys Ile Lys Thr Lys Lys Tyr Lys Leu Cys Ala Ala Ala Lys Ile Gln 
    210                 215                 220                 


Leu Lys Glu Arg Lys Leu Phe Leu Leu Ile Thr Val Asp Ile Pro Lys 
225                 230                 235                 240 


Ala Glu Ser Val Pro Val Lys Gly Lys Val Met Gly Val Asp Leu Gly 
                245                 250                 255     


Val Ile Asn Pro Ala Tyr Val Ala Val Asn Asp Gly Pro Glu Arg Ser 
            260                 265                 270         


Arg Ile Gly Asn Gly Glu Ala Phe Gln Lys Gln Arg Asp Val Phe Arg 
        275                 280                 285             


Arg Arg Phe Arg Glu Leu Gln Arg Ser Gln Leu Thr Gln Gly Gly His 
    290                 295                 300                 


Gly Arg Lys His Lys Thr Lys Ala Thr Glu Ile Leu Arg Gly Lys Glu 
305                 310                 315                 320 


Arg Asn Trp Val Gln Thr Glu Asn His Arg Ile Ser Arg Glu Ile Val 
                325                 330                 335     


Asn Leu Ala Ser Arg Trp Lys Val Glu Thr Ile Gln Met Glu Ser Leu 
            340                 345                 350         


Lys Gly Phe Gly Lys Asn Gln Glu Gly Glu Val Glu Tyr Asn His Lys 
        355                 360                 365             


Arg Leu Leu Gly Arg Trp Ser Tyr Phe Glu Leu Gln Lys Asp Ile Glu 
    370                 375                 380                 


Tyr Lys Ala Ala Met Ala Gly Ile Ala Val Gln Tyr Val Asn Pro Ala 
385                 390                 395                 400 


Tyr Thr Ser Gln Thr Cys His Val Cys Gly Gln Arg Gly Asn Arg Ile 
                405                 410                 415     


Glu Arg Asp Thr Phe Ile Cys Thr Asn Pro Glu Cys Thr Cys Tyr Asn 
            420                 425                 430         


Gln Ala Gln Asp Ala Asp Met Asn Ala Ala Ile Asn Ile Ala Lys Ser 
        435                 440                 445             


Lys Asp Val Ile Lys 
    450             


<210>  207
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.270012

<400>  207

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Asp Gly 
1               5                   10                  15      


Leu Ser Asp Glu Glu Arg Lys Ala Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Gln Lys Glu Leu Ala Lys Ala Glu Arg Gln Lys Met Pro 
65                  70                  75                  80  


Asp Val Asp Val Ile Glu Glu Leu Arg Glu Arg Leu Ser Ala Ala Glu 
                85                  90                  95      


Gln Glu Met Ser Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Asn Thr Leu Ala Tyr Arg Phe Ala Thr Glu Ile Glu Thr 
        115                 120                 125             


Asn Ile Phe Gly Gln Ile Leu Ala Arg Leu Glu Asn Asn Ala Gln Ala 
    130                 135                 140                 


Val Phe Leu Thr Asp Ala Pro Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asn Ser 
                165                 170                 175     


Ile Lys Ile Glu Cys Glu Gly Gly Glu Phe Tyr Leu Arg Trp Tyr Ser 
            180                 185                 190         


Gly Leu Arg Phe His Phe Asn Phe Gly Lys Asp Arg Ser Gly Asn Arg 
        195                 200                 205             


Leu Ile Val Gln Arg Cys Leu Lys Leu Asp Lys Glu Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Met Val Lys Arg Asp Gly Ser 
225                 230                 235                 240 


Thr Lys Phe Phe Leu Leu Met Val Val Asn Ile Pro Gln Glu Tyr Val 
                245                 250                 255     


Glu Leu Asn Lys His Ile Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Pro Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Thr Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Thr Thr Ala Gly Gly Lys Gly Arg Thr 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Gln Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asn Phe Ala 
            340                 345                 350         


Leu Gln Thr His Ala Ala Thr Ile His Leu Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Ser Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Thr Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Arg Val Glu Lys Ile Arg Pro Ala Phe Thr Ser 
                405                 410                 415     


Arg Thr Cys Ser Cys Cys Gly His Glu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Gln Gln Phe Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  208
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.272451

<400>  208

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Glu Thr Leu Ala Tyr Lys Phe Ala Thr Glu Ile Glu Thr 
        115                 120                 125             


Asn Val Phe Gly Gln Ile Leu Ala Cys Leu Lys Gln Ala Ala Gln Ser 
    130                 135                 140                 


Asn Phe Lys Asn Asp Ala Lys Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asp Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Val Lys Leu Phe Leu Leu Leu Val Val Ser Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Thr Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Thr 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Thr His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Phe Tyr Glu Leu Gln Asn Met Ile Thr Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Cys Cys Gly Arg Gln Gly Phe Arg Ser Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Tyr Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Glu Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  209
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.274429

<400>  209

Met Lys Asn Asn Val Glu Glu Lys Arg Pro Asp Lys Glu Lys Arg Leu 
1               5                   10                  15      


Thr Lys Val Ala Thr Phe Gln Ile Val Lys Pro Val Asn Met Ser Trp 
            20                  25                  30          


Ser Glu Phe Gly Lys Met Leu Arg Asp Val Arg Tyr Arg Leu Ser Arg 
        35                  40                  45              


Leu Ala Asn Met Ala Val Ser Glu Ala Tyr Gln Asn Leu His Gln Arg 
    50                  55                  60                  


Tyr Arg Leu Lys Asn Gln Asn Ala Pro Lys Ser Val Lys Ile Gly Gln 
65                  70                  75                  80  


Ile Ser Arg Asp Leu Arg Lys Ile Leu Leu Glu Glu Gly Leu Glu Glu 
                85                  90                  95      


Glu Asn Leu Ser Lys Tyr Ser Lys Met Cys Val Leu Pro Asp Thr Ile 
            100                 105                 110         


Thr Gly Ala Phe Ser Arg Tyr Lys Leu Ser Thr Ile Asp Trp Arg Lys 
        115                 120                 125             


Val Leu Thr Gly Lys Ile Ser Ile Pro Asn Tyr Lys Ala Asn Leu Ser 
    130                 135                 140                 


Ile Pro Ile Arg Cys Asp Lys Pro Gln Gln Arg Arg Leu Glu Arg Thr 
145                 150                 155                 160 


Glu Thr Gly Glu Ile Glu Val Asp Leu Met Ile Cys Asn Lys Pro Tyr 
                165                 170                 175     


Pro Arg Val Leu Leu Ser Thr Arg Thr Ile Ser Asp Gly Gln Arg Ser 
            180                 185                 190         


Val Leu Glu Arg Leu Val Leu Asn Asn Ala Asn Ser Leu Pro Gly Tyr 
        195                 200                 205             


Arg His Arg Ile Phe Glu Ile Lys Glu Lys Arg Asn Glu Trp Tyr Leu 
    210                 215                 220                 


Ser Val Thr Tyr Asp Phe Pro Lys Ala Glu Thr Thr Lys Leu His Ser 
225                 230                 235                 240 


Asp Ile Ile Val Gly Val Asp Leu Gly Trp Ser Val Pro Leu Tyr Ala 
                245                 250                 255     


Ala Ile Asn Asn Gly Tyr Ala Arg Ile Gly Tyr Lys Gln Leu Lys Pro 
            260                 265                 270         


Leu Gly Asp Ser Ile Lys Ala Leu Gln Arg Gln Thr Ile Ala Arg Arg 
        275                 280                 285             


Arg Ser Ile Gln Arg Gly Gly Thr Gln Asp Leu Ala Ala Pro Thr Ala 
    290                 295                 300                 


Arg Ser Gly His Gly Ile Lys Arg Ile Leu Gln Pro Ile Glu Lys Leu 
305                 310                 315                 320 


Glu Gly Lys Ile Asp Asn Ala Tyr Lys Thr Leu Asn His Gln Leu Ser 
                325                 330                 335     


His Cys Val Ile Glu Phe Ala Lys Asn His Gly Ala Gly Val Ile Gln 
            340                 345                 350         


Ile Glu Asn Leu Lys Gly Leu Ala Glu Glu Leu Ser Gly Thr Phe Ile 
        355                 360                 365             


Gly Gln Asn Trp Arg Tyr Tyr Gln Leu Gln Glu Phe Ile Lys Tyr Lys 
    370                 375                 380                 


Ala Lys Glu Ala Gly Ile Ile Val Lys Glu Val Asn Pro Phe Tyr Thr 
385                 390                 395                 400 


Ser Arg Arg Cys Ser Glu Cys Gly Tyr Ile His Lys Asp Phe Thr Phe 
                405                 410                 415     


Glu Tyr Arg Gln Ala Asn Arg Lys Asn Gly Lys Ser Thr Met Phe Glu 
            420                 425                 430         


Cys Pro Lys Lys Glu Glu Lys Gly Cys Lys Pro Leu Asn Ala Asp Tyr 
        435                 440                 445             


Asn Ala Ala Arg Asn Leu Ala Thr Ser Asp Ile Glu Asp Lys Ile Arg 
    450                 455                 460                 


Leu Gln Cys Lys Glu Gln Gly Ile Glu Tyr Lys Glu Ile Lys Glu Lys 
465                 470                 475                 480 


<210>  210
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.277378

<400>  210

Val Thr Leu Leu Val Lys Val Val Lys Ile His Leu Ile Ser Glu Gln 
1               5                   10                  15      


Phe Asp Lys Ala Gly Asn Arg Ile Asp Tyr Lys Glu Val Asn Lys Ile 
            20                  25                  30          


Leu Trp Glu Leu Gln Lys Gln Thr Arg Glu Ala Lys Asn Lys Thr Val 
        35                  40                  45              


Gln Leu Leu Trp Glu Trp Asn Asn Phe Ser Ser Asp Tyr Val Lys Ala 
    50                  55                  60                  


Ser Gly Ile Tyr Pro Lys Ala Lys Asp Ile Phe Gly Tyr Ser Ser Val 
65                  70                  75                  80  


His Gly Gln Ala Asn Lys Glu Leu Arg Thr Lys Leu Ile Leu Asn Ser 
                85                  90                  95      


Ser Asn Leu Ser Thr Thr Thr Met Asp Val Cys Lys Ile Phe Asn Thr 
            100                 105                 110         


Tyr Lys Lys Glu Val Trp Glu Gly Lys Arg Ser Val Pro Ser Tyr Lys 
        115                 120                 125             


Ser Asp Gln Pro Leu Asp Leu His Asn Asp Ser Ile Lys Leu Ile Tyr 
    130                 135                 140                 


Glu Asn Lys Glu Phe Tyr Val Arg Leu Gly Leu Leu Asn Arg Ala Gly 
145                 150                 155                 160 


Phe Ala Lys Tyr Gly Phe Lys Asp Gly Phe Arg Phe Lys Met Gln Val 
                165                 170                 175     


Lys Asp Asn Ser Thr Lys Thr Ile Leu Glu Arg Cys Phe Asp Gly Ile 
            180                 185                 190         


Tyr Thr Ile Val Ala Ser Lys Leu Leu Tyr Asp Gln Lys Lys Asn Arg 
        195                 200                 205             


Trp Lys Leu Asn Leu Ser Tyr Ser Phe Asp Asn Lys Asn Ile Ser Glu 
    210                 215                 220                 


Leu Asp Lys Glu Lys Ile Leu Gly Val Asp Val Gly Val Ser Cys Pro 
225                 230                 235                 240 


Leu Val Ala Ser Val Phe Gly Asp Arg Asp Arg Phe Ile Ile Lys Gly 
                245                 250                 255     


Gly Glu Ile Glu Lys Phe Arg Lys Ser Val Glu Ala Arg Arg Arg Ser 
            260                 265                 270         


Met Leu Glu Gln Thr Lys Tyr Cys Gly Asp Gly Arg Ile Gly His Gly 
        275                 280                 285             


Arg Lys Lys Arg Thr Glu Pro Ala Leu Asn Ile Gly Asp Lys Ile Ala 
    290                 295                 300                 


Arg Phe Arg Asp Thr Thr Asn His Lys Tyr Ser Arg Ala Leu Ile Glu 
305                 310                 315                 320 


Tyr Ala Val Lys Lys Gly Cys Gly Thr Ile Gln Met Glu Lys Leu Thr 
                325                 330                 335     


Gly Ile Thr Ser Lys Ala Asp Arg Phe Leu Lys Asp Trp Thr Tyr Tyr 
            340                 345                 350         


Asp Leu Gln Thr Lys Ile Glu Asn Lys Ala Lys Glu Val Gly Ile Asn 
        355                 360                 365             


Val Val Tyr Ile Ala Pro Lys Tyr Thr Ser Gln Arg Cys Ser Lys Cys 
    370                 375                 380                 


Gly Tyr Ile His Lys Asp Asn Arg Pro Asn Gln Ala Lys Phe Arg Cys 
385                 390                 395                 400 


Leu Lys Cys Asp Phe Glu Ser Asn Ala Asp Tyr Asn Ala Ser Gln Asn 
                405                 410                 415     


Ile Gly Ile Lys Asn Ile Asp Lys Thr Ile Lys Lys Glu Arg Lys Lys 
            420                 425                 430         


Gln Lys Ser Glu Ala Gln Val Asn Glu Lys 
        435                 440         


<210>  211
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.280852

<400>  211

Met Ala Gly Lys Lys Lys Asp Lys Asp Val Ile Asn Lys Thr Leu Ser 
1               5                   10                  15      


Val Arg Ile Ile Arg Pro Arg Tyr Ser Asp Asp Ile Glu Lys Glu Ile 
            20                  25                  30          


Ser Asp Glu Lys Ala Lys Arg Lys Gln Asp Gly Lys Thr Gly Glu Leu 
        35                  40                  45              


Asp Arg Ala Phe Phe Ser Glu Leu Lys Ser Arg Asn Pro Asp Ile Ile 
    50                  55                  60                  


Thr Asn Asp Glu Leu Phe Pro Leu Phe Thr Glu Ile Gln Lys Asn Leu 
65                  70                  75                  80  


Thr Glu Ile Tyr Asn Lys Ser Ile Ser Leu Leu Tyr Met Lys Leu Ile 
                85                  90                  95      


Val Glu Glu Glu Gly Gly Ser Thr Ala Ser Ala Leu Ser Ala Gly Pro 
            100                 105                 110         


Tyr Lys Glu Cys Lys Ala Arg Phe Asn Ser Tyr Ile Ser Leu Gly Leu 
        115                 120                 125             


Arg Gln Lys Ile Gln Ser Asn Phe Arg Arg Lys Glu Leu Lys Gly Phe 
    130                 135                 140                 


Gln Val Ser Leu Pro Thr Ala Lys Ser Asp Arg Phe Pro Ile Pro Phe 
145                 150                 155                 160 


Cys His Gln Val Glu Asn Gly Lys Gly Gly Phe Lys Val Tyr Glu Thr 
                165                 170                 175     


Gly Asp Asp Phe Ile Phe Glu Val Pro Leu Ile Lys Tyr Thr Ala Thr 
            180                 185                 190         


Asn Lys Lys Ser Thr Ser Gly Lys Asn Tyr Thr Lys Val Gln Leu Asn 
        195                 200                 205             


Asn Pro Pro Val Pro Met Asn Val Pro Leu Leu Leu Ser Thr Met Arg 
    210                 215                 220                 


Arg Arg Gln Thr Lys Lys Gly Met Gln Trp Asn Lys Asp Glu Gly Thr 
225                 230                 235                 240 


Asn Ala Glu Leu Arg Arg Val Met Ser Gly Glu Tyr Lys Val Ser Tyr 
                245                 250                 255     


Ala Glu Ile Ile Arg Arg Thr Arg Phe Gly Lys His Asp Asp Trp Phe 
            260                 265                 270         


Val Asn Phe Ser Ile Lys Phe Lys Asn Lys Thr Asp Glu Leu Asn Gln 
        275                 280                 285             


Asn Val Arg Gly Gly Ile Asp Ile Gly Val Ser Asn Pro Leu Val Cys 
    290                 295                 300                 


Ala Val Thr Asn Gly Leu Asp Arg Tyr Ile Val Ala Asn Asn Asp Ile 
305                 310                 315                 320 


Met Ala Phe Asn Glu Arg Ala Met Ala Arg Arg Arg Thr Leu Leu Arg 
                325                 330                 335     


Lys Asn Arg Phe Lys Arg Ser Gly His Gly Ala Lys Asn Lys Leu Glu 
            340                 345                 350         


Pro Ile Thr Val Leu Thr Glu Lys Asn Glu Arg Phe Arg Lys Ser Ile 
        355                 360                 365             


Leu Gln Arg Trp Ala Arg Glu Val Ala Glu Phe Phe Lys Arg Thr Ser 
    370                 375                 380                 


Ala Ser Val Val Asn Met Glu Asp Leu Ser Gly Ile Thr Glu Arg Glu 
385                 390                 395                 400 


Asp Phe Phe Ser Thr Lys Leu Arg Thr Thr Trp Asn Tyr Arg Leu Met 
                405                 410                 415     


Gln Thr Thr Ile Glu Asn Lys Leu Lys Glu Tyr Gly Ile Ala Val Asn 
            420                 425                 430         


Tyr Ile Ser Pro Lys Tyr Thr Ser Gln Thr Cys His Ser Cys Gly Lys 
        435                 440                 445             


Arg Asn Asp Tyr Phe Thr Phe Ser Tyr Arg Ser Glu Asn Asn Tyr Pro 
    450                 455                 460                 


Pro Phe Glu Cys Lys Glu Cys Asn Lys Val Lys Cys Asn Ala Asp Phe 
465                 470                 475                 480 


Asn Ala Ala Lys Asn Ile Ala Leu Lys Val Val Leu 
                485                 490         


<210>  212
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.281050

<400>  212

Met Pro Asp Thr Asp Lys Gly Lys Arg Leu Thr Lys Val Ala Thr Phe 
1               5                   10                  15      


Gln Ile Val Lys Pro Val Asn Met Ser Trp Asn Glu Phe Gly Lys Met 
            20                  25                  30          


Leu His Asp Val Arg Tyr Arg Tyr Trp Arg Leu Ala Asn Met Ala Val 
        35                  40                  45              


Cys Glu Asn Tyr Met Arg Phe Tyr Arg Trp Arg Thr Gln Gln Thr Asp 
    50                  55                  60                  


Thr Asn Asp His Tyr Lys Val Lys Ile Ile Asn Gly Ile Leu Arg Lys 
65                  70                  75                  80  


Met Leu Ile Glu Glu Lys Asn Ala Asp Glu Lys Glu Leu Ser Arg Tyr 
                85                  90                  95      


Ser Arg Asp Gly Ala Val Ser Gly Tyr Val Tyr Gly Ala Phe Thr Gln 
            100                 105                 110         


Thr Lys Leu Ser Ala Ile Thr Ser Lys Ser Lys Trp Gly Glu Val Ile 
        115                 120                 125             


Lys Gly Lys Ser Ala Leu Pro Leu Phe Lys Arg Asp Thr Ser Ile Pro 
    130                 135                 140                 


Ile Met Cys Thr Asp Lys Lys Pro Ser Met Ile Glu Lys Thr Ala Ser 
145                 150                 155                 160 


Gly Glu Tyr Glu Val Asp Leu Arg Ile Cys Leu Lys Asp Lys Gln Leu 
                165                 170                 175     


Arg Pro Asn Gly Tyr Pro Ser Val Leu Leu Ser Thr Thr Lys Ile Ser 
            180                 185                 190         


Asp Gly Gln Lys Ala Val Leu Glu Arg Leu Val Ser Asn Lys Thr Asn 
        195                 200                 205             


Ser Leu Pro Gly Tyr Arg His Arg Phe Phe Glu Val Lys Glu Lys Arg 
    210                 215                 220                 


Gly Asp Trp Tyr Leu Ser Val Ser Tyr Asp Phe Pro Gln Ala Glu Ala 
225                 230                 235                 240 


Thr Arg Leu His Pro Asp Ile Ile Val Gly Val Asp Leu Gly Trp Ser 
                245                 250                 255     


Val Pro Leu Tyr Ala Ala Ile Asn Asn Gly Tyr Ala Arg Ile Gly Trp 
            260                 265                 270         


Arg Lys Leu Glu Pro Leu Ala Lys Ser Ile Lys His Leu Gln Lys Gln 
        275                 280                 285             


Thr Ile Val Arg Arg Arg Ser Phe Gln Lys Gly Gly Lys Lys Asp Leu 
    290                 295                 300                 


Ala Ala Ser Thr Ala Arg Thr Gly His Gly Ile Lys Arg Ile Leu Gln 
305                 310                 315                 320 


Pro Ile Glu Lys Leu Glu Gly Lys Ile Asp Asn Ala Tyr Lys Thr Leu 
                325                 330                 335     


Asn His Gln Leu Ser His Cys Ile Ile Glu Phe Ala Lys Asn His Gly 
            340                 345                 350         


Ala Gly Val Ile Gln Ile Glu Asn Leu Lys Gly Leu Ala Glu Glu Leu 
        355                 360                 365             


Ser Gly Thr Phe Ile Gly Gln Asn Trp Arg Tyr His Gln Leu Gln Glu 
    370                 375                 380                 


Phe Ile Lys Tyr Lys Ala Glu Glu Ala Gly Ile Ala Val Lys Glu Val 
385                 390                 395                 400 


Asn Pro Arg Tyr Thr Ser Arg Arg Cys Ser Lys Cys Gly Tyr Ile His 
                405                 410                 415     


Ile Gly Phe Asp Arg Glu Tyr Arg Asp Lys Asn Arg Lys Asn Gly Lys 
            420                 425                 430         


Ser Thr Met Phe Glu Cys Pro Glu Cys Ser Lys Arg Ile Lys Asp Tyr 
        435                 440                 445             


Lys Pro Leu Asn Ala Asp Tyr Asn Ala Ala Lys Asn Leu Ala Thr Ala 
    450                 455                 460                 


Asp Ile Glu Glu Lys Ile Arg Leu Gln Cys Lys Glu Gln Gly Ile Glu 
465                 470                 475                 480 


Tyr Lys Glu Leu Pro Lys Asp 
                485         


<210>  213
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.285333

<400>  213

Met Pro Thr Ile Thr Arg Lys Ile Lys Leu Glu Leu Cys Thr Lys Gly 
1               5                   10                  15      


Leu Ser Glu Glu Glu Arg Lys Ala Gln Trp Asn Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Ser Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Leu Val Trp Leu Lys His Lys Glu His 
    50                  55                  60                  


Gln Thr Leu Lys Ala Asp Leu Ala Lys Ala Lys Lys Gln Lys Ile Gln 
65                  70                  75                  80  


Asp Glu Lys Thr Ile Ala Glu Leu Glu Ser Arg Leu Lys Ser Cys Glu 
                85                  90                  95      


Ser Glu Met Ser Asp Gln Glu Leu Ala Ile Cys Lys Tyr Thr Asp Glu 
            100                 105                 110         


Met Ser Ser Lys Thr Leu Ser Tyr Lys Phe Ala Thr Glu Leu Glu Leu 
        115                 120                 125             


Asn Ile Tyr Ala Gln Ile Leu Thr Gln Val Gln Ser Lys Val Tyr Ala 
    130                 135                 140                 


Asp Phe Gln Asn Asp Gln Lys Asp Val Arg Asp Gly Lys Arg Ala Ile 
145                 150                 155                 160 


Arg Thr Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Arg Asn Asn 
                165                 170                 175     


Ile Arg Met Glu Pro Val Lys Lys Gly Arg Glu Tyr Glu Phe Tyr Ile 
            180                 185                 190         


Lys Trp Tyr Asn Asp Ile Arg Phe Gln Leu Ile Phe Gly Lys Asp Arg 
        195                 200                 205             


Ser Asn Asn Arg Leu Ile Leu Gln Arg Cys Phe Lys Leu Asp Glu Asn 
    210                 215                 220                 


Cys Val Glu Asp Tyr Gln Met Arg Thr Ser Ser Ile Lys Met Val Lys 
225                 230                 235                 240 


Gly Ala Asn Gly Thr Glu Leu Phe Leu Tyr Leu Val Val Asp Ile Pro 
                245                 250                 255     


Gln Glu Lys His Ile Leu Asn Asn Lys Ile Val Val Gly Val Asp Leu 
            260                 265                 270         


Gly Ile Asn Val Pro Ala Tyr Val Ala Thr Asn Val Thr Asp Asp Arg 
        275                 280                 285             


Lys Ala Ile Gly Asp Arg Glu His Phe Leu Asn Thr Arg Met Ala Ile 
    290                 295                 300                 


Ser Lys Arg Phe His Ser Phe Gln Arg Leu Lys Gly Thr Thr Gly Gly 
305                 310                 315                 320 


Arg Gly Lys Thr Lys Lys Leu Glu Pro Leu Glu Arg Leu Lys Glu Lys 
                325                 330                 335     


Glu Arg Asn Trp Val His Thr Gln Asn His Leu Phe Ser Arg Asp Val 
            340                 345                 350         


Ile Thr Phe Ala Leu His Val Lys Ala Ala Thr Ile Gln Met Glu Asp 
        355                 360                 365             


Leu Ser Gly Tyr Gly Lys Asp Asp Glu Gly Asn Val Val Glu Glu Lys 
    370                 375                 380                 


Lys Phe Leu Leu Gly Lys Trp Ser Tyr Tyr Glu Leu Gln Glu Met Ile 
385                 390                 395                 400 


Lys Tyr Lys Ala Lys Lys Val Gly Met Arg Val Asn Phe Ile Lys Pro 
                405                 410                 415     


Ala Tyr Ser Ser Gln Thr Cys Ser Trp Cys Gly Glu Arg Gly Glu Arg 
            420                 425                 430         


Asn Ser Thr Ser Phe Val Cys Thr Asn Ser Glu Cys Ser His Tyr Gly 
        435                 440                 445             


Glu Asp Leu His Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Arg Ser 
    450                 455                 460                 


Lys Asn Ile Ile Arg Tyr Glu 
465                 470     


<210>  214
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.286285

<400>  214

Met Ile Ile Thr Arg Lys Ile Gln Ile Leu Phe Ala Ala Gln Gly Glu 
1               5                   10                  15      


Glu Phe Lys Lys Asp Lys Asp Thr Leu Tyr Lys Trp Ser Asn Ile Val 
            20                  25                  30          


His His Ala Ser Asn Ile Val Ala Ser Asn Lys Tyr Val Cys Asp His 
        35                  40                  45              


Leu Gln Gly Met Val Tyr Leu Thr Glu Glu Gly Lys Glu Ala Val Ser 
    50                  55                  60                  


Glu Leu Ser Gln Lys Val Asp Asp Ile Phe Asn Thr Ser Arg Met Asn 
65                  70                  75                  80  


Thr Thr Tyr Arg Met Ile Ser Ser Leu Tyr Lys Gly Glu Ile Pro Thr 
                85                  90                  95      


Asp Ile Leu Ser Cys Val Asn Met Gln Val Ser Lys Leu Tyr Asn Lys 
            100                 105                 110         


Glu Arg Lys Lys Met Ala Asp Gly Asp Arg Ser Leu Arg Ser Tyr Arg 
        115                 120                 125             


Ser Asn Ile Pro Ile Pro Phe Ser Ala Asn Ser Leu Met Arg Lys Trp 
    130                 135                 140                 


Lys Tyr Ala Asp Lys Glu Tyr Ser Phe Asp Leu Phe Gly Ile Pro Phe 
145                 150                 155                 160 


Lys Val Val Leu Gly Lys Asp Lys Ser Asn Asn Arg Ser Ile Leu Glu 
                165                 170                 175     


Arg Leu Met Asp Gly Thr Tyr Lys Ala Ala Thr Ser Ser Ile Lys Ile 
            180                 185                 190         


Gln Asn Cys Glu Asp Glu Thr Gly Lys Lys Thr Arg Lys Phe Phe Leu 
        195                 200                 205             


Leu Leu Cys Val Glu Ile Pro Asp Lys Ser Tyr Ala Gly Arg Glu Asp 
    210                 215                 220                 


Asn Ile Leu Phe Ala Glu Leu Ser Ile Asp His Pro Leu Leu Val Ser 
225                 230                 235                 240 


Phe Pro Ile Lys Lys Glu Glu Ser Lys Pro Ile Pro Ile Gly Asn Lys 
                245                 250                 255     


Gln Ser Tyr Leu Tyr Lys Arg Leu Gln Ile Gln Lys Gly Leu Asp Ser 
            260                 265                 270         


Cys Lys Ala Ser Cys Lys Trp Asn Lys Gly Gly Arg Gly Arg Lys Arg 
        275                 280                 285             


Lys Met Lys Ser Thr Glu Arg Phe Lys Ala Lys Glu His Asn Phe Val 
    290                 295                 300                 


Asp Ala Tyr Met His Gln Ile Ser Ala Ala Leu Ile Lys Phe Ala Ile 
305                 310                 315                 320 


Lys His Asp Ile Gly Lys Leu Cys Leu Val Asp Val Asp Lys Lys Ile 
                325                 330                 335     


Lys Glu Ala Lys Glu Ser Pro Phe Val Leu Arg Asn Trp Ser Tyr Tyr 
            340                 345                 350         


Ser Leu Leu Thr Lys Ile Gln Tyr Lys Ala Lys Met Asn Gly Ile Thr 
        355                 360                 365             


Val Val Met Val Asp Lys Asn Val Leu 
    370                 375         


<210>  215
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.286678

<400>  215

Met Pro Thr Ile Thr Arg Lys Ile Arg Leu His Leu Cys Thr Asp Gly 
1               5                   10                  15      


Leu Ser Glu Glu Glu Arg Lys Ala Gln Trp Lys Met Leu Tyr Arg Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Ile Ser Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Thr Ser Leu Lys Thr Glu Leu Leu Lys Ala Lys Lys Ala Asp Asp Glu 
65                  70                  75                  80  


Glu Thr Val Ala Glu Leu Glu Ala Arg Ile Asn Val Leu Asn Ala Glu 
                85                  90                  95      


Leu Ser Ala Gln Glu Glu Ala Ile Cys Ser Tyr Ala Thr Glu Met Ala 
            100                 105                 110         


Thr Arg Thr Leu Ala Gly Lys Phe Ala Ser Glu Leu Asp Leu Asn Ile 
        115                 120                 125             


Tyr Gly Gln Ile Leu Ala Glu Val Lys Ser Val Val Phe Lys Asn Phe 
    130                 135                 140                 


Asn Ser Asp Ser Lys Asp Val Arg Glu Gly Lys Arg Ser Ile Arg Thr 
145                 150                 155                 160 


Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Lys Thr Ile Arg 
                165                 170                 175     


Leu Glu Ala Val Lys Lys Glu Ser Ser Ser Lys His Asp Glu Asp Glu 
            180                 185                 190         


Tyr Glu Val Tyr Leu Asn Trp Tyr Lys Ser Ser Arg Thr Glu Lys Lys 
        195                 200                 205             


Ala Ile Arg Phe Arg Leu Asp Phe Gly Lys Asp Lys Ser Asn Asn Gln 
    210                 215                 220                 


Gln Ile Val Lys Arg Cys Leu Asn Leu Asp Asn Thr Ser Ser Glu Ser 
225                 230                 235                 240 


Tyr Gln Leu Gln Thr Ser Ser Ile Gln Met Lys Lys Gly Ser Glu Gly 
                245                 250                 255     


Ala Glu Leu Tyr Leu Leu Leu Val Val Asn Ile Pro Gln Asp Gln His 
            260                 265                 270         


Val Leu Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Ile Asn Val 
        275                 280                 285             


Pro Ala Tyr Val Ala Thr Asn Cys Thr Glu Glu Arg Lys Ser Ile Gly 
    290                 295                 300                 


Asp Arg Glu His Phe Leu Asn Ala Arg Ile Ala Phe His Arg Arg Phe 
305                 310                 315                 320 


His Ser Phe Gln Lys Leu Lys Gly Thr Thr Gly Gly Arg Gly Arg Lys 
                325                 330                 335     


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Glu Lys Glu Arg Asn Trp 
            340                 345                 350         


Val His Thr Gln Asn His Leu Ile Ser Arg Asp Val Ile Asn Phe Ala 
        355                 360                 365             


Leu Gln Thr Lys Ala Ala Thr Ile Gln Met Glu Asp Leu Ser Gly Tyr 
    370                 375                 380                 


Gly Lys Asp Glu Glu Gly Asn Val Lys Pro Glu Asn Lys Phe Leu Gln 
385                 390                 395                 400 


Ser Arg Trp Ser Tyr Phe Glu Leu Gln Ser Met Ile Lys Tyr Lys Ala 
                405                 410                 415     


Ala Lys Cys Gly Ile Lys Val Asn Leu Ile Asn Pro Ser Tyr Thr Ser 
            420                 425                 430         


Gln Thr Cys Ser Trp Cys Gly Gln Met Gly Val Arg Glu Ser Thr Ser 
        435                 440                 445             


Phe Val Cys Gln Asn Pro Glu Cys Lys Lys Tyr Gly Lys Asp Ile His 
    450                 455                 460                 


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Arg Ser Asn Lys Thr Val 
465                 470                 475                 480 


Lys Asn Glu 
            


<210>  216
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.287128

<400>  216

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Arg Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Glu Glu Arg Lys Ala Gln Trp Met Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Ser Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Gln Ser Thr Ala Ala Glu Leu Leu Lys Ala Lys Lys Asn Asn Ala Asp 
65                  70                  75                  80  


Glu Gly Thr Ile Ser Thr Leu Glu Asp Lys Val Glu Thr Leu Lys Thr 
                85                  90                  95      


Glu Met Ser Ala Gln Gly Ile Ala Ile Cys Asn Tyr Ala Thr Glu Met 
            100                 105                 110         


Ala Thr Arg Thr Leu Ala Gly Lys Phe Ala Ser Glu Leu Glu Leu Asn 
        115                 120                 125             


Ile Tyr Gly Gln Ile Leu Ala Glu Val Lys Asn Val Val His Thr Asn 
    130                 135                 140                 


Phe Thr Asn Asp Ala Lys Glu Val Arg Glu Gly Lys Arg Ser Ile Arg 
145                 150                 155                 160 


Thr Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Lys Ser Ile 
                165                 170                 175     


Lys Ile Glu Pro Val Lys Ala Ser Ser Gln Asn Glu Gly Gln Asp Asp 
            180                 185                 190         


Tyr Glu Phe Tyr Leu Lys Trp Tyr Asn Gly Leu Lys Phe Ile Leu His 
        195                 200                 205             


Phe Gly Lys Asp Arg Ser Asn Asn Arg Gln Ile Leu Lys Arg Cys Phe 
    210                 215                 220                 


Gly Leu Asp Asn Leu Cys Asn Glu Arg Tyr Gln Met Arg Thr Ser Ser 
225                 230                 235                 240 


Ile Gln Met Lys Lys Gly Ser Asn Gly Met Glu Leu Tyr Leu Leu Leu 
                245                 250                 255     


Val Leu Ser Ile Pro Lys Glu Gln His Ser Leu Asn Lys Lys Val Val 
            260                 265                 270         


Val Gly Val Asp Leu Gly Ile Asn Val Pro Ala Tyr Val Ala Thr Asn 
        275                 280                 285             


Cys Thr Glu Glu Arg Arg Ala Ile Gly Asp Arg Glu Gln Phe Leu Asn 
    290                 295                 300                 


Thr Arg Met Ala Ile Ile Arg Arg Lys His Ser Phe Gln Arg Leu Lys 
305                 310                 315                 320 


Gly Thr Ala Gly Gly Arg Gly Arg Lys Lys Lys Leu Asp Pro Leu Glu 
                325                 330                 335     


Arg Leu Arg Glu Thr Glu Arg Asn Trp Val His Thr Gln Asn His Leu 
            340                 345                 350         


Tyr Ser Arg Asp Ile Ile Lys Phe Ala Leu Glu Thr Lys Ala Ala Thr 
        355                 360                 365             


Ile Gln Met Glu Lys Leu Lys Gly Phe Gly Arg Asp Asp Asn Gly Asn 
    370                 375                 380                 


Val Ile Glu Glu Lys Lys Phe Leu Leu Gly Lys Trp Ser Tyr Tyr Glu 
385                 390                 395                 400 


Leu Gln Asn Met Ile Lys Tyr Lys Ala Gly Lys Val Gly Ile Lys Val 
                405                 410                 415     


Asn Phe Ile Ala Pro Ala Tyr Thr Ser Gln Thr Cys Ser Cys Cys Gly 
            420                 425                 430         


Val Arg Asp Asp Arg Asn Arg Lys Ser Thr Ser Phe Ile Cys His Asn 
        435                 440                 445             


Pro Asp Cys Gln Met Tyr Gly Lys Glu Ile His Ala Asp Tyr Asn Ala 
    450                 455                 460                 


Ala Arg Asn Ile Ala Arg Ser Lys Asn Val Ile Lys Asp Glu 
465                 470                 475             


<210>  217
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.287826

<400>  217

Met Pro Ala Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Met Lys His Ala Asp Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Asp Glu Leu Ile Ala Glu Leu Arg Glu Lys Leu Ser Leu Ala Glu 
                85                  90                  95      


Gln Glu Met Thr Asp Gln Glu Leu Ala Ile Cys Asn Tyr Ala Thr Glu 
            100                 105                 110         


Met Ala Thr Ser Thr Leu Ala Tyr Asn Phe Ala Lys Glu Ile Glu Thr 
        115                 120                 125             


Glu Ile Phe Gly Gln Ile Leu Ala Cys Leu Glu Asn Asn Ala His Ala 
    130                 135                 140                 


Val Phe Val Asp Asp Ser Pro Thr Val Arg Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Lys Ser 
                165                 170                 175     


Ile Arg Ile Val Glu Lys Asp Gly Glu Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Met Arg Phe Leu Leu Thr Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Ile Ile Met Lys Arg Cys Leu Lys Met Asp Gln Asp Phe Glu Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Met Val Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Ile Val Val Asn Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Asn Ile Val Val Gly Val Asp Leu Gly Val Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Thr Arg Met Gln Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Thr 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asn Phe Ala 
            340                 345                 350         


Val Gln Thr Arg Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Gln Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Phe Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Val Lys Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Gln Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Ala Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  218
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.287896

<400>  218

Met Ala Gly Gln Arg His Thr Lys Val Ala Lys Phe Gln Ile Leu Lys 
1               5                   10                  15      


Pro Ala Ala Asp Met Arg Trp Ser Glu Leu Gly Arg Leu Leu Arg Asp 
            20                  25                  30          


Ala Gln Tyr Arg Val Tyr Arg Leu Ala Asn Leu Ala Leu Ser Glu Lys 
        35                  40                  45              


Tyr Leu Arg Phe His Leu Phe Arg Thr Gly Gln Thr Glu Ser Leu Pro 
    50                  55                  60                  


Glu Cys Arg Ile Gly Arg Leu Asn Arg Gln Leu Arg Gln Met Leu Lys 
65                  70                  75                  80  


Asp Glu Gly Gly Ala Asp Asp Ser Val Leu Asp Arg Phe Ser Arg Thr 
                85                  90                  95      


Gly Ala Leu Pro Asp Thr Val Val Gly Ala Leu Trp Gln Tyr Arg Leu 
            100                 105                 110         


His Ala Leu Thr Lys Gly Glu Lys Trp Asn Lys Val Thr Arg Gly Glu 
        115                 120                 125             


Thr Ala Leu Pro Thr Phe Arg Arg Ser Met Ala Leu Pro Ile Arg Cys 
    130                 135                 140                 


Asp Lys Arg Ile His His Arg Leu Glu Arg Ala Ala Leu Asp Ser Val 
145                 150                 155                 160 


Glu Leu Asp Leu Met Ile Cys Thr Arg Pro Tyr Pro Arg Val Ile Leu 
                165                 170                 175     


Lys Thr Ala Lys Leu Asp Asp Gly Ala Ala Ala Ile Leu Glu Arg Leu 
            180                 185                 190         


Leu Asp Asn Glu Gly Gln Leu Leu Glu Gly Tyr Arg Gln Arg Cys Phe 
        195                 200                 205             


Glu Val Arg Tyr Ala Glu Asp Glu Lys Ala Trp Trp Leu His Val Thr 
    210                 215                 220                 


Tyr Asp Ser Pro Ala Thr Pro Ala Pro His Leu Ser Lys Asp Ile Ile 
225                 230                 235                 240 


Val Gly Val Asp Leu Gly Phe Ser Cys Pro Met Tyr Val Ala Leu Ser 
                245                 250                 255     


Asn Gly Asp Ala Arg Leu Gly Arg Arg Gln Phe Ala Ala Leu Ala Ala 
            260                 265                 270         


Arg Ile Arg Ser Leu Gln Thr Gln Val Met Ala Arg Arg Arg Gln Met 
        275                 280                 285             


Leu Ser Gly Gly Lys Ala Ser Leu Ser Gly Asp Thr Ala Arg Ser Gly 
    290                 295                 300                 


His Gly Arg Lys Arg Lys Leu Leu Pro Ile Glu Ser Leu Glu Gly Arg 
305                 310                 315                 320 


Ile Asn Arg Ala Tyr Thr Thr Leu Asn His Gln Leu Ser Ile Ser Val 
                325                 330                 335     


Val His Phe Ala Val His His Gly Ala Gly Val Ile Gln Ile Glu Asn 
            340                 345                 350         


Leu Glu Gly Leu Gln Asn Glu Leu Thr Gly Thr Phe Leu Gly Gln Arg 
        355                 360                 365             


Trp Arg Tyr His Gln Leu Gln Glu Phe Leu Asn Tyr Lys Ala Asn Glu 
    370                 375                 380                 


Ala Gly Ile Glu Val Arg Arg Val Asn Pro Arg Tyr Thr Ser Arg Arg 
385                 390                 395                 400 


Cys Ser Lys Cys Gly Tyr Ile His Val Asp Phe Asn Arg Ala Phe Arg 
                405                 410                 415     


Asp Ala Ala Arg Gln Glu Gly Lys Val Ala Arg Phe Cys Cys Pro Lys 
            420                 425                 430         


Cys Glu Tyr Glu Ala His Pro Asp Tyr Asn Ala Ala Arg Asn Leu Ala 
        435                 440                 445             


Thr Val Asp Ile Glu Gly Ile Ile Lys Val Gln Cys Glu Arg Gln Gly 
    450                 455                 460                 


Ile Asp Arg Pro Ser Val Glu Asn Gln Asp Glu Val Ala Lys 
465                 470                 475             


<210>  219
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.287936

<400>  219

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Gln Glu Arg Lys Asp Gln Trp Asn Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Gly Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Arg Ala Leu Glu Lys Ala Lys Lys Gln Lys Ala Pro 
65                  70                  75                  80  


Asp Glu Glu Val Ile Ala Glu Leu Ser Gln Gln Val Ala Thr Ala Glu 
                85                  90                  95      


Gln Glu Met Asp Glu Gln Ala Lys Ala Ile Cys Gln Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Thr Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Gly Gln Ile Leu Thr Cys Leu Arg Gln Gly Val Phe Ser 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ser Ile 
145                 150                 155                 160 


Arg Thr Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asp Ser 
                165                 170                 175     


Leu Arg Ile Gly Phe Glu Asp Gly Glu Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Arg Phe Asp Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Gln Arg Cys Met Lys Met Asp Lys Asp Tyr Glu Gly Asp 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Met Val Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Pro Lys Phe Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu Arg Val 
                245                 250                 255     


Glu Leu Asn Lys Asn Ile Val Val Gly Val Asp Leu Gly Ile Asn Ala 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Thr Thr Pro Glu Arg Lys Gln Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Glu Arg Met Ala Phe Gln Arg Arg Phe 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Ser Thr Thr Gly Gly Arg Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu Gln Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Ile Asp Phe Ala 
            340                 345                 350         


Val Lys Ala Arg Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Arg Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Thr Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly His Gln Gly Phe Arg Glu Gly Ile Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys Phe Gly Glu Lys Glu His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Glu Ile Ile 
    450                 455                 460                 


Lys Asn Asn Glu Glu 
465                 


<210>  220
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.288450

<400>  220

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Ser Leu Cys Thr Asp Gly 
1               5                   10                  15      


Leu Ser Asp Glu Gln Leu Lys Glu Gln Arg Gln Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Ala Ala Asn Asn Val Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Leu Lys His Ala Asp Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Arg Asp Leu Ala Arg Ala Glu Lys Gln Lys Ser Pro 
65                  70                  75                  80  


Asp Glu Ala Leu Ile Ser Glu Leu Arg Ser Lys Leu Ala Ala Ala Gln 
                85                  90                  95      


Arg Glu Met Thr Glu Gln Glu Leu Ala Ile Cys Arg Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Val Thr Glu Met Glu Thr 
        115                 120                 125             


His Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Tyr Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ser Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Ser Asp Ser 
                165                 170                 175     


Val Arg Ile Glu Gln Glu Ala Asp Glu Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Ile Arg Phe Arg Leu Val Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Lys Arg Cys Leu Lys Leu Asp Lys Asp Tyr Glu Gly Asp 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Val Gln Met Val Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Pro Lys Thr Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu Gln Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Ile Val Leu Gly Val Asp Leu Gly Ile Asn Tyr 
            260                 265                 270         


Pro Val Tyr Ala Ala Thr Asn Cys Thr Glu Glu Arg Ile Tyr Phe Gly 
        275                 280                 285             


Glu Arg Glu His Phe Leu Asn Thr Arg Met Gln Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr Gly Gly Lys Gly Arg Lys 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu Arg Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Gln Lys Thr Val Asp Phe Ala 
            340                 345                 350         


Leu Gln Thr His Ala Ala Thr Ile His Leu Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Arg Asp Ser Asp Gly Ser Ala Glu Glu Lys Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Gln Met Ile Thr Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Gln Thr Cys Ser Trp Cys Gly Gln Arg Gly Phe Arg Gln Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys Cys Gly Glu Lys Glu Gln 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Lys Ser Lys Asp Val Ile 
    450                 455                 460                 


Lys Asp Asp Asp Glu 
465                 


<210>  221
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.288712

<400>  221

Met Ser Ile Val Thr Arg Lys Ile Glu Leu Ile Pro Asp Ile Glu Asn 
1               5                   10                  15      


Leu Thr His Glu Glu Ser Asn Gln Arg Cys Tyr Lys Leu Leu Tyr Asn 
            20                  25                  30          


Ile Asp Lys Lys Leu Tyr Lys Leu Ala Asn Leu Leu Val Cys Gln Leu 
        35                  40                  45              


Phe Gly Leu Asp Asn Leu Leu Ser Leu Met Arg Leu Gln Asn Asp Glu 
    50                  55                  60                  


Tyr Val Lys Phe Gln Ser Lys Leu Ala Ser Lys Ser Ile Ser Lys Glu 
65                  70                  75                  80  


Thr Gln Lys Asn Ile Lys Glu His Met Lys Glu Ile Asp Lys Glu Leu 
                85                  90                  95      


Leu Ala Arg Lys Ala Glu Ile Ala Pro Lys Ser Pro Leu Thr Phe Ala 
            100                 105                 110         


Tyr Arg Ala Ile Lys Gly Ser Leu Tyr Ala Lys Asp Leu Pro Ser Asp 
        115                 120                 125             


Ile Phe Asn Thr Leu Lys Gln Asp Val Phe Lys His Phe Asn Glu Thr 
    130                 135                 140                 


Lys Lys Glu Gln Leu Arg Gly Glu Arg Ser Leu Ala Thr Tyr Lys Arg 
145                 150                 155                 160 


Gly Ile Pro Ile Pro Phe Ser Leu Met Lys Lys Asn Val Ile Val Ser 
                165                 170                 175     


Glu Gly Asp Asn Tyr Tyr Leu Thr Trp Phe Glu Glu Thr Arg Phe Lys 
            180                 185                 190         


Leu Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg Ala Ile Ile Asp Asn 
        195                 200                 205             


Cys Leu Lys Thr Asn Lys Tyr Lys Leu Cys Thr Ala Ala Lys Ile Gln 
    210                 215                 220                 


Leu Lys Asn Lys Lys Leu Phe Phe Leu Val Thr Val Asp Ile Pro Glu 
225                 230                 235                 240 


Thr Lys Asn Thr Ile Ile Lys Gly Lys Val Met Gly Val Asp Leu Gly 
                245                 250                 255     


Val Val His Pro Ala Tyr Val Ala Val Asn Asp Gly Pro Glu Arg Ser 
            260                 265                 270         


Leu Ile Gly Asp Gly Asp Ala Phe Gln Lys Gln Arg Asp Val Phe Arg 
        275                 280                 285             


Arg Arg Phe Lys Glu Leu Gln Arg Cys Gln Leu Thr Gln Gly Gly His 
    290                 295                 300                 


Gly Arg Lys His Lys Thr Lys Ala Thr Glu Ile Leu Arg Gly Lys Glu 
305                 310                 315                 320 


Arg Asn Trp Val Gln Thr Glu Asn His Arg Ile Ser Arg Lys Ile Val 
                325                 330                 335     


Asn Leu Ala Ile Arg Trp Lys Val Glu Ser Ile Gln Met Glu Asn Leu 
            340                 345                 350         


Lys Gly Phe Gly Lys Asp Ser Glu Gly Glu Val Glu Thr Lys His Lys 
        355                 360                 365             


Arg Leu Leu Gly Arg Trp Ser Tyr Phe Glu Leu Gln Lys Asp Ile Glu 
    370                 375                 380                 


Tyr Lys Ala Gln Lys Ala Gly Ile Lys Val Val Tyr Ile Asn Pro Ala 
385                 390                 395                 400 


Tyr Thr Ser Gln Thr Cys His Val Cys Gly Lys Lys Gly Asp Arg Thr 
                405                 410                 415     


Glu Arg Asp Thr Phe Ile Cys Leu Asn Thr Glu Cys Ser Cys Tyr Gly 
            420                 425                 430         


Lys Pro Gln Asp Ala Asp Met Asn Ala Ala Ile Asn Ile Ala Arg Ser 
        435                 440                 445             


Lys Asn Ile Val Lys 
    450             


<210>  222
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.289248

<400>  222

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Met Leu Cys Ser Glu Gly 
1               5                   10                  15      


Leu Ser Asp Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Gln Thr Pro 
65                  70                  75                  80  


Asp Glu Gly Leu Ile Ala Glu Leu Ser Arg Lys Leu Ser Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Ala Asp Gln Glu Leu Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Thr Leu Ser Tyr Asn Phe Ala Lys Glu Ile Glu Thr 
        115                 120                 125             


Asn Ile Phe Gly Gln Ile Leu Thr Cys Leu Arg Gln Gly Val Tyr Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Lys Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Lys Ser 
                165                 170                 175     


Leu Lys Ile Glu Ala Glu Gly Gly Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Leu Thr Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Met Ile Val Lys Arg Cys Met Lys Met Asp Glu Asp Phe Glu Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Leu Ala Lys Arg Asp Gly Lys 
225                 230                 235                 240 


Pro Lys Leu Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Val Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Thr Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Ala Gly Gly Lys Gly Arg Thr 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Asp Ala Glu Arg Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asn Phe Ala 
            340                 345                 350         


Val Gln Ala Arg Ala Ala Thr Ile His Met Glu Asp Met Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Lys Asp Gly Asn Ala Asp Glu Lys Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Phe Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ser 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Val Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Gln Gly Glu Arg Lys Ser Thr Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys His Tyr Gly Glu Ser Ile His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Asn Asp Ile Val 
    450                 455                 460                 


Lys Glu Asn Glu 
465             


<210>  223
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.289726

<400>  223

Met Val Ile Thr Arg Lys Ile Glu Val Phe Val Cys Glu Ser Asp Asn 
1               5                   10                  15      


Asp Leu Arg Arg Ser Tyr Tyr Glu Lys Leu Tyr Asp Ile Arg Asn Ile 
            20                  25                  30          


Ala Gln Glu Ala Ala Asn Arg Ala Thr Ser Met Leu Tyr Ala Ile Asp 
        35                  40                  45              


Asn Leu Ile Pro Cys Leu Asp Glu Asp Ser Arg Lys Leu Ile Gln Tyr 
    50                  55                  60                  


Ile Gly Ala Lys Gly Thr Pro Ala Ser Arg Gln Asn Ala Ala Tyr Thr 
65                  70                  75                  80  


Ile Met Ser His Leu Tyr Lys Asp Arg Met Pro Gly Ile Met Asp Met 
                85                  90                  95      


Leu Ser Asn Leu Ala Gln Tyr Val Thr Lys Asn Tyr Ser Glu Asp Arg 
            100                 105                 110         


Lys Arg Gly Met Tyr Lys Asn Ala Leu Arg Ser Tyr Lys Cys Ser Leu 
        115                 120                 125             


Pro Val Pro Tyr Gln Lys Lys Ser Phe Lys Gly Leu Arg Phe Asn Trp 
    130                 135                 140                 


Tyr Glu Asp Ser Asp Gly Asp Ala His Glu Gly Cys Phe Phe Ser Leu 
145                 150                 155                 160 


Ala Gly Val Pro Leu Gln Met Arg Phe Gly Arg Asp Arg Ser Asn Asn 
                165                 170                 175     


Arg Leu Ile Val Glu Arg Val Ile Ser Gly Glu Tyr Lys Met Cys Thr 
            180                 185                 190         


Ser Ser Leu Lys Phe Asp Gly Lys Lys Leu Phe Leu Leu Leu Cys Val 
        195                 200                 205             


Asp Ile Pro Lys Gln Glu Ala Asn Val Asp Pro Lys Lys Thr Leu Tyr 
    210                 215                 220                 


Ala Tyr Leu Gly Val Met Asn Pro Ile Ile Cys Thr Cys Asp Val Arg 
225                 230                 235                 240 


Ala Lys Gln Glu Tyr Asp Ser Gly Tyr Lys Cys Phe Glu Ile Gly Thr 
                245                 250                 255     


Lys Glu Glu Phe Asn Tyr Arg Arg Arg Gln Ile Gln Glu Ala Val Arg 
            260                 265                 270         


Arg Cys Gln Ile Asn Asn Arg Tyr Ser Ser Gly Gly Lys Gly Arg Lys 
        275                 280                 285             


Lys Lys Cys Gln Ala Ile Glu Arg Trp His Glu Lys Glu Lys Asn Tyr 
    290                 295                 300                 


Val Asp Thr Lys Leu His Thr Tyr Ser Arg Met Leu Val Asp Leu Ala 
305                 310                 315                 320 


Val Ala His Lys Cys Gly Thr Ile Val Leu Leu Asn Gln Lys Lys Arg 
                325                 330                 335     


Glu Asp Lys Ala Lys Asp Asp Asn Gln Asn Gly Glu Pro Phe Val Leu 
            340                 345                 350         


Arg Asn Trp Ser Tyr Tyr Asn Leu Lys Asp Lys Ile Gly Tyr Lys Cys 
        355                 360                 365             


Lys Leu Ala Gly Ile Lys Leu Val Gln Asp Lys Glu Glu Thr Glu Glu 
    370                 375                 380                 


Glu 
385 


<210>  224
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.289802

<400>  224

Met Val Ile Thr Arg Lys Ile Glu Val Phe Val Cys Glu Asp Ser Lys 
1               5                   10                  15      


Asp Leu Arg Lys Glu Tyr Tyr Asp Lys Ile Tyr Lys Cys Arg Asp Ile 
            20                  25                  30          


Ala Val Lys Thr Ala Asn Leu Gly Val Ser His Leu Phe Met Leu Asp 
        35                  40                  45              


Asn Thr Thr Pro Tyr Leu Ser Asp Asp Asp Arg Glu Lys Leu Thr Phe 
    50                  55                  60                  


Leu Gly Cys Ser Gly Lys Lys Ala Thr Lys Gln Asn Ala Pro Tyr Val 
65                  70                  75                  80  


Ala Ala Ser Glu Lys Phe Lys Gly Gln Ala Asp Met Ser Met Leu Ser 
                85                  90                  95      


Ser Val Leu Gln Asn Val Gly Lys Met Tyr Gln Asp Asp Lys Lys Lys 
            100                 105                 110         


Gly Met Trp Ser Lys Ser Leu Arg Ser Tyr Lys Ala Asn Met Pro Ile 
        115                 120                 125             


Pro Phe Lys Ala Ser Cys Tyr Arg Asn Leu Arg Phe Ala Asp Tyr Asn 
    130                 135                 140                 


Asp Lys Glu Asp Lys Pro His Asn Gly Cys Phe Phe Thr Leu Met Gly 
145                 150                 155                 160 


Ile Pro Phe Gln Cys Lys Phe Gly Lys Asp Arg Ser Gly Asn Arg Ile 
                165                 170                 175     


Ile Met Gln Ala Val Val Asp Gly Lys Tyr Lys Met Cys Thr Ser Ser 
            180                 185                 190         


Leu Gln Ile Asp Gly Lys Lys Ile Phe Leu Leu Leu Cys Val Asp Ile 
        195                 200                 205             


Pro Lys Lys Val Val Lys Leu Asp Glu Ser Lys Thr Leu Tyr Ala Phe 
    210                 215                 220                 


Leu Gly Val Met Asn Pro Ile Val Cys Thr Thr Asp Ile Lys Gln Lys 
225                 230                 235                 240 


Gly Asp Ile Asp Thr Asp Trp Lys Leu Trp Glu Ile Gly Thr Glu Ala 
                245                 250                 255     


Glu Phe Asn Tyr Arg Arg Arg Gln Ile Gln Glu Ala Val Lys Arg Cys 
            260                 265                 270         


Gln Val Asn Asn Arg Tyr Ser Arg Gly Gly His Gly Arg Phe Ala Lys 
        275                 280                 285             


Thr Lys Ala Ile Glu Arg Trp Arg Ala Val Glu Arg Asn Tyr Val Asp 
    290                 295                 300                 


Thr Lys Leu His Thr Tyr Ser Lys Met Leu Ile Asp Leu Ala Val Lys 
305                 310                 315                 320 


His Lys Cys Gly Lys Ile Val Leu Met Asn Gln Leu His Arg Glu Asp 
                325                 330                 335     


Ala Ala Lys Asp Asp Lys Phe Val Leu Arg Asn Trp Ser Tyr His Ser 
            340                 345                 350         


Leu Arg Thr Lys Ile Asp Tyr Lys Ala Lys Met Tyr Gly Ile Lys Val 
        355                 360                 365             


Glu Val Glu Lys 
    370         


<210>  225
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.290380

<400>  225

Met Pro Val Ile Thr Arg Lys Ile Lys Leu Asn Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Asp Glu Arg Lys Ala Gln Trp Lys Met Leu Tyr Arg Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Glu His Val Ser Ser Met Val Arg Leu Lys Asn Ala Glu Tyr 
    50                  55                  60                  


Thr Ser Leu Val Ser Asp Leu Met Lys Ala Lys Lys Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Ala Ile Thr Asp Leu Glu Ala Lys Ile Glu Ser Leu Lys Ser Glu 
                85                  90                  95      


Met Thr Ala Gln Glu Glu Ala Ile Cys Cys Tyr Ala Thr Glu Met Ala 
            100                 105                 110         


Thr Arg Thr Leu Ala Gly Lys Phe Ala Ser Glu Leu Asp Leu Asp Ile 
        115                 120                 125             


Tyr Gly Gln Ile Leu Ala Glu Val Lys Ser Val Val Phe Lys Asn Phe 
    130                 135                 140                 


Asn Ser Asp Ser Lys Glu Val Arg Glu Gly Asn Arg Ser Ile Arg Thr 
145                 150                 155                 160 


Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Lys Thr Ile Arg 
                165                 170                 175     


Leu Glu Ala Val Lys Lys Glu Leu Ser Gly Lys His Asp Glu Asp Glu 
            180                 185                 190         


Tyr Asp Phe Tyr Leu Asn Trp Tyr Lys Ser Ser Arg Thr Asp Lys Lys 
        195                 200                 205             


Ala Ile Arg Phe Arg Leu Tyr Phe Gly Lys Asp Lys Ser Asn Asn Gln 
    210                 215                 220                 


Gln Ile Val Lys Arg Cys Leu His Leu Asp Ser Thr Ser Ser Glu Asn 
225                 230                 235                 240 


Tyr Gln Met Gln Thr Ser Ser Ile Gln Met Lys Lys Gly Pro Glu Gly 
                245                 250                 255     


Ala Glu Leu Tyr Leu Leu Leu Val Val Asn Ile Pro Gln Glu Gln His 
            260                 265                 270         


Ala Leu Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Ile Asn Val 
        275                 280                 285             


Pro Ala Tyr Val Ala Thr Asn Cys Thr Glu Glu Arg Lys Ala Ile Gly 
    290                 295                 300                 


Asp Arg Asp His Phe Leu Asn Thr Arg Met Ala Phe Ser Arg Arg Phe 
305                 310                 315                 320 


His Ser Phe Gln Arg Leu Lys Gly Thr Ser Gly Gly Lys Gly Arg Lys 
                325                 330                 335     


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Glu Lys Glu Arg Asn Trp 
            340                 345                 350         


Val His Thr Gln Asn His Leu Ile Ser Arg Asp Val Ile Asn Phe Ala 
        355                 360                 365             


Leu Gln Val Lys Ala Ala Thr Ile Gln Met Glu Asp Leu Ser Gly Tyr 
    370                 375                 380                 


Gly Lys Asp Glu Glu Gly Asn Val Lys Pro Glu Asn Lys Phe Leu Gln 
385                 390                 395                 400 


Ser Lys Trp Ser Tyr Phe Glu Leu Gln Ser Met Ile Lys Tyr Lys Ala 
                405                 410                 415     


Ala Lys Cys Gly Ile Lys Val Asn Leu Ile Ala Pro Ala Tyr Thr Ser 
            420                 425                 430         


Gln Thr Cys Ser Trp Cys Gly Gln Met Gly Ile Arg Glu Ser Thr Ser 
        435                 440                 445             


Phe Val Cys Gln Asn Pro Glu Cys Lys Gln Tyr Gly Lys Asp Ile His 
    450                 455                 460                 


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Arg Ser Asn Lys Ile Val 
465                 470                 475                 480 


Lys Asn Glu 
            


<210>  226
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.292901

<400>  226

Met Arg Ile Ser Lys Thr Leu Ser Leu Arg Ile Val Arg Pro Phe Tyr 
1               5                   10                  15      


Thr Pro Glu Val Glu Ala Gly Ile Lys Ala Glu Lys Asp Lys Arg Glu 
            20                  25                  30          


Ala Gln Gly Gln Thr Arg Ser Leu Asp Ala Lys Phe Phe Asn Glu Leu 
        35                  40                  45              


Lys Lys Lys His Ser Glu Ile Ile Leu Ser Ser Glu Phe Tyr Ser Leu 
    50                  55                  60                  


Leu Ser Glu Val Gln Arg Gln Leu Thr Ser Ile Tyr Asn His Ala Met 
65                  70                  75                  80  


Ser Asn Leu Tyr His Lys Ile Ile Val Glu Gly Glu Lys Thr Ser Thr 
                85                  90                  95      


Ser Lys Ala Leu Ser Asn Ile Gly Tyr Asp Glu Cys Lys Ala Ile Phe 
            100                 105                 110         


Pro Ser Tyr Met Ala Leu Gly Leu Arg Gln Lys Ile Gln Ser Asn Phe 
        115                 120                 125             


Arg Arg Arg Asp Leu Lys Asn Phe Arg Met Ala Val Pro Thr Ala Lys 
    130                 135                 140                 


Ser Asp Lys Phe Pro Ile Pro Ile Tyr Arg Gln Val Asp Gly Ser Lys 
145                 150                 155                 160 


Gly Gly Phe Lys Ile Ser Glu Asn Asp Gly Lys Asp Phe Ile Val Glu 
                165                 170                 175     


Leu Pro Leu Val Asp Tyr Val Ala Glu Glu Val Lys Thr Ala Lys Gly 
            180                 185                 190         


Arg Phe Thr Lys Ile Asn Ile Ser Lys Pro Pro Lys Ile Lys Asn Ile 
        195                 200                 205             


Pro Val Ile Leu Ser Thr Leu Arg Arg Arg Gln Ser Gly Gln Trp Phe 
    210                 215                 220                 


Ser Asp Asp Gly Thr Asn Ala Glu Ile Arg Arg Val Ile Ser Gly Glu 
225                 230                 235                 240 


Tyr Lys Val Ser Trp Ile Glu Ile Val Arg Arg Thr Arg Phe Gly Lys 
                245                 250                 255     


His Asp Asp Trp Phe Val Asn Met Val Ile Lys Tyr Asp Lys Pro Glu 
            260                 265                 270         


Glu Gly Leu Asp Ser Lys Val Val Gly Gly Ile Asp Val Gly Val Ser 
        275                 280                 285             


Ser Pro Leu Val Cys Ala Leu Asn Asn Ser Leu Asp Arg Tyr Phe Val 
    290                 295                 300                 


Lys Ser Ser Asp Ile Ile Ala Phe Asn Lys Arg Ala Met Ala Arg Arg 
305                 310                 315                 320 


Arg Thr Leu Leu Arg Gln Asn Lys Tyr Lys Arg Ser Gly His Gly Ser 
                325                 330                 335     


Lys Asn Lys Leu Glu Pro Ile Thr Val Leu Thr Glu Lys Asn Glu Arg 
            340                 345                 350         


Phe Lys Lys Ser Ile Met Gln Arg Trp Ala Lys Glu Val Ala Glu Phe 
        355                 360                 365             


Phe Arg Gly Lys Gly Ala Ser Val Val Arg Met Glu Glu Leu Ser Gly 
    370                 375                 380                 


Leu Lys Glu Lys Asp Asn Phe Phe Ser Ser Tyr Leu Arg Met Tyr Trp 
385                 390                 395                 400 


Asn Tyr Gly Gln Leu Gln Gln Ile Ile Glu Asn Lys Leu Lys Glu Tyr 
                405                 410                 415     


Gly Ile Lys Val Asn Tyr Val Ser Pro Lys Asp Thr Ser Lys Lys Cys 
            420                 425                 430         


His Ser Cys Thr His Ile Asn Glu Phe Phe Thr Phe Glu Tyr Arg Gln 
        435                 440                 445             


Lys Asn Asn Phe Pro Leu Phe Lys Cys Glu Lys Cys Gly Val Glu Cys 
    450                 455                 460                 


Ser Ala Asp Tyr Asn Ala Ala Lys Asn Met Ala Ile Ala 
465                 470                 475         


<210>  227
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.293203

<400>  227

Met Glu Glu Lys Thr Lys Arg Leu Gln Lys Val Ala Lys Phe Gln Ile 
1               5                   10                  15      


Val Lys Pro Val Asn Met Thr Trp Val Glu Leu Gly Lys Met Leu Arg 
            20                  25                  30          


Asp Val Arg Tyr Arg Leu Trp Arg Leu Ala Asn Met Ala Val Cys Glu 
        35                  40                  45              


Asn Tyr Met Arg Phe Tyr Gln Trp Arg Ile Gly Lys Thr Asp Ala Asn 
    50                  55                  60                  


Glu Asn His Lys Val Lys Ile Leu Asn Arg Arg Leu Arg Glu Met Ile 
65                  70                  75                  80  


Ile Glu Glu Lys Gln Ala Asp Ala Lys Glu Leu Met Arg Tyr Ser Arg 
                85                  90                  95      


Asp Gly Val Val Ser Gly Tyr Ile Cys Gly Ala Phe Glu Lys Ile His 
            100                 105                 110         


Leu Ser Ala Ile Lys Asn Lys Ser Lys Trp Arg Glu Val Ile Arg Gly 
        115                 120                 125             


Lys Ser Asn Leu Pro Leu Phe Lys Arg Asp Leu Pro Ile Pro Ile Asn 
    130                 135                 140                 


Cys Ser Asp His Lys Pro Ser Leu Ile Ala Lys Thr Glu Ser Asp Glu 
145                 150                 155                 160 


Tyr Glu Val Asp Leu Arg Ile Cys Gln Lys Pro Tyr Pro Arg Val Leu 
                165                 170                 175     


Leu Ser Thr Ala Lys Ile Ser Gly Gly Glu Arg Ala Ile Leu Glu Arg 
            180                 185                 190         


Leu Val Ser Asn Lys Thr Asn Ser Leu Pro Gly Tyr Arg His Arg Phe 
        195                 200                 205             


Phe Glu Ile Lys Glu Lys Pro Lys Gly Arg Trp Asn Leu His Val Thr 
    210                 215                 220                 


Tyr Asp Phe Ala Arg Ser Glu Ala Thr Met Leu His Ser Asp Ile Ile 
225                 230                 235                 240 


Val Gly Val Asp Leu Gly Trp Ser Val Pro Leu Tyr Ala Ala Val Asn 
                245                 250                 255     


Lys Gly His Ala Arg Ile Gly Trp Arg Lys Leu Glu Pro Leu Ala Lys 
            260                 265                 270         


Arg Ile Arg His Leu Gln Lys Gln Val Lys Ala Arg Arg Leu Ser Val 
        275                 280                 285             


Gln Lys Gly Gly Gln Arg Asp Leu Ala Ala Pro Thr Ala Arg Ala Gly 
    290                 295                 300                 


His Gly Arg Lys Arg Ile Leu Gln Pro Ile Glu Lys Leu Glu Gly Lys 
305                 310                 315                 320 


Ile Asp Asp Ala Tyr Lys Thr Leu Asn His Gln Leu Ser His Cys Val 
                325                 330                 335     


Ile Glu Phe Ala Lys Asn Asn Gly Ala Gly Val Ile Gln Val Glu Asn 
            340                 345                 350         


Leu Glu Gly Leu Lys Asp Thr Leu Thr Gly Thr Phe Ile Gly Gln Asn 
        355                 360                 365             


Trp Arg Tyr Asn Gln Leu Gln Asn Tyr Ile Glu Tyr Lys Ala Lys Glu 
    370                 375                 380                 


Ala Gly Met Glu Leu Lys Lys Val Asn Pro Cys Gln Thr Ser Gln Arg 
385                 390                 395                 400 


Cys Ser Asn Cys Gly Phe Ile His Arg Asp Phe Thr Phe Glu Tyr Arg 
                405                 410                 415     


Gln Ala Asn Lys Lys Asn Gly Lys Ala Ala Met Phe Glu Cys Pro Glu 
            420                 425                 430         


Cys Ser Lys Lys Glu Asn Tyr Lys Pro Leu Asn Ala Asp Tyr Asn Ala 
        435                 440                 445             


Ala Arg Asn Leu Ala Thr Ala Gly Ile Glu Gly Lys Ile Arg Leu Gln 
    450                 455                 460                 


Cys Glu Lys Gln Gly Ile Glu Tyr Lys Gly Leu Pro Glu Glu 
465                 470                 475             


<210>  228
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.294190

<400>  228

Met Ser Lys Ile Thr Arg Lys Ile Glu Ile Ile Pro Asp Ile Glu Gly 
1               5                   10                  15      


Leu Thr His Asp Glu Ser Asn Lys Lys Cys Tyr Gly Ala Phe Tyr Thr 
            20                  25                  30          


Phe Asp Lys Asn Leu Tyr Lys Val Ala Asn Leu Leu Val Ser Gln Leu 
        35                  40                  45              


Tyr Gly Leu Asp Asn Leu Leu Ser Leu Met Arg Leu Gln Asn Asp Glu 
    50                  55                  60                  


Tyr Val Lys Cys Gln Ser Lys Leu Ser Leu Lys Ser Thr Thr Asp Ala 
65                  70                  75                  80  


Glu Lys Glu Asn Leu Lys Lys Arg Met Lys Lys Ile Asp Ala Glu Leu 
                85                  90                  95      


Val Ser Ile Lys Asn Gly Met Ala Pro Lys His Pro Gln Thr Phe Ala 
            100                 105                 110         


Tyr Arg Ala Val Thr Asn Cys Val Tyr Ala Lys Asn Ile Pro Ser Asp 
        115                 120                 125             


Ile Leu Asn Thr Leu Lys Gln Asp Val Tyr Lys His Phe Asn Asp Thr 
    130                 135                 140                 


Lys Lys Glu Gln Phe Leu Gly Glu Arg Ser Leu Thr Thr Tyr Lys Arg 
145                 150                 155                 160 


Gly Met Pro Val Pro Phe Ser Ile Glu Lys Lys His Ala Ile Val Cys 
                165                 170                 175     


Asp Gly Asp Asn Tyr Tyr Leu Pro Trp Phe Glu Asp Thr Arg Phe Arg 
            180                 185                 190         


Leu Asn Phe Gly Arg Asp Lys Ser Asn Asn Arg Ala Ile Ile Asp Asn 
        195                 200                 205             


Cys Ile Lys Thr Lys Arg Tyr Lys Leu Cys Ala Ala Ala Lys Ile Gln 
    210                 215                 220                 


Leu Lys Asp Lys Lys Leu Phe Leu Leu Val Thr Val Asp Ile Pro Ala 
225                 230                 235                 240 


Thr Glu Thr Thr Ser Val Lys Gly Lys Val Met Gly Val Asp Leu Gly 
                245                 250                 255     


Val Val Asn Pro Ala Tyr Val Ala Val Asn Asp Gly Pro Glu Arg Ser 
            260                 265                 270         


Arg Ile Gly Asn Gly Glu Ala Phe Gln Lys Gln Arg Asp Val Phe Arg 
        275                 280                 285             


Arg Arg Phe Arg Glu Leu Gln Arg Ser Gln Leu Thr Gln Gly Gly His 
    290                 295                 300                 


Gly Arg Lys His Lys Thr Lys Ala Thr Glu Thr Leu Arg Gly Lys Glu 
305                 310                 315                 320 


Arg Asn Trp Val Gln Thr Glu Asn His Arg Ile Ser Arg Glu Ile Val 
                325                 330                 335     


Asn Leu Ala Ser Arg Trp Lys Val Glu Cys Ile Gln Met Glu Ser Leu 
            340                 345                 350         


Lys Gly Tyr Gly Lys Asn Gln Glu Gly Glu Val Glu Asp Asn His Lys 
        355                 360                 365             


Arg Leu Leu Gly Arg Trp Ser Tyr Phe Glu Leu Gln Lys Asp Ile Glu 
    370                 375                 380                 


Tyr Lys Ala Ala Met Val Gly Ile Gln Val Lys Tyr Ile Asn Pro Ala 
385                 390                 395                 400 


Tyr Thr Ser Gln Thr Cys His Val Cys Gly Gln Arg Gly Asn Arg Ile 
                405                 410                 415     


Glu Arg Asp Thr Phe Ile Cys Thr Asn Pro Glu Cys Thr Cys Tyr Asn 
            420                 425                 430         


Gln Ala Gln Asp Ala Asp Met Asn Ala Ala Ile Asn Ile Ala Lys Ser 
        435                 440                 445             


Lys Asp Val Val Lys 
    450             


<210>  229
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.294406

<400>  229

Met Pro Thr Ile Thr Arg Lys Ile Glu Met Lys Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Gln Glu Arg Lys Asp Gln Trp Asn Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Leu Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Gly Leu Leu Arg Ala Leu Glu Lys Ala Lys Lys Gln Lys Ile Pro 
65                  70                  75                  80  


Asp Glu Glu Val Ile Ala Glu Leu Ser Gln Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Gln Glu Met Asp Asp Gln Ala Lys Ala Ile Cys Gln Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Gly Ile Phe Thr Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Thr Arg Asp Val Lys Arg Gly Glu Arg Ser Ile 
145                 150                 155                 160 


Arg Thr Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asn Asp Ser 
                165                 170                 175     


Leu Arg Ile Glu Leu Glu Asp Gly Glu Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Arg Phe Asp Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Arg Arg Cys Leu Asn Met Asp Glu Asp Tyr Glu Gly Asp 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Met Val Lys Arg Glu Gly Leu 
225                 230                 235                 240 


Ala Lys Phe Phe Leu Leu Met Val Val Asn Ile Pro Gln Glu Gln Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Ile Val Val Gly Val Asp Leu Gly Ile Asn Ala 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Ser Glu Arg Lys Gln Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Glu Arg Met Ala Phe Gln Arg Arg Phe 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr Gly Gly Arg Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu Gln Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Ile Asp Phe Ala 
            340                 345                 350         


Val Lys Ser Arg Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Arg Asp Gly Asn Ala Asp Asp Lys Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Ser Met Ile Thr Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly His Gln Gly Phe Arg Glu Gly Ile Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys Tyr Gly Glu Lys Glu His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Ile Glu Ile Val 
    450                 455                 460                 


Lys Asn Asn Glu Glu 
465                 


<210>  230
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.294601

<400>  230

Met Lys Asp Tyr Ile Arg Lys Thr Leu Ser Leu Arg Ile Leu Arg Pro 
1               5                   10                  15      


Tyr Tyr Gly Glu Glu Ile Glu Lys Glu Ile Ala Ala Ala Lys Lys Lys 
            20                  25                  30          


Ser Gln Ala Glu Gly Gly Asp Gly Ala Leu Asp Asn Lys Phe Trp Asp 
        35                  40                  45              


Arg Leu Lys Ala Glu His Pro Glu Ile Ile Ser Ser Arg Glu Phe Tyr 
    50                  55                  60                  


Asp Leu Leu Asp Ala Ile Gln Arg Glu Thr Thr Leu Tyr Tyr Asn Arg 
65                  70                  75                  80  


Ala Ile Ser Lys Leu Tyr His Ser Leu Ile Val Glu Arg Glu Gln Val 
                85                  90                  95      


Ser Thr Ala Lys Ala Leu Ser Ala Gly Pro Tyr His Glu Phe Arg Glu 
            100                 105                 110         


Lys Phe Asn Ala Tyr Ile Ser Leu Gly Leu Arg Glu Lys Ile Gln Ser 
        115                 120                 125             


Asn Phe Arg Arg Lys Glu Leu Ala Arg Tyr Gln Val Ala Leu Pro Thr 
    130                 135                 140                 


Ala Lys Ser Asp Thr Phe Pro Ile Pro Ile Tyr Lys Gly Phe Asp Lys 
145                 150                 155                 160 


Asn Gly Lys Gly Gly Phe Lys Val Arg Glu Ile Glu Asn Gly Asp Phe 
                165                 170                 175     


Val Ile Asp Leu Pro Leu Met Ala Tyr His Arg Val Gly Gly Lys Ala 
            180                 185                 190         


Gly Arg Glu Tyr Ile Glu Leu Asp Arg Pro Pro Ala Val Leu Asn Val 
        195                 200                 205             


Pro Val Ile Leu Ser Thr Ser Arg Arg Arg Ala Asn Lys Thr Trp Phe 
    210                 215                 220                 


Arg Asp Glu Gly Thr Asp Ala Glu Ile Arg Arg Val Met Ala Gly Glu 
225                 230                 235                 240 


Tyr Lys Val Ser Trp Val Glu Ile Leu Gln Arg Lys Arg Phe Gly Lys 
                245                 250                 255     


Pro Tyr Gly Gly Trp Tyr Val Asn Phe Thr Ile Lys Tyr Gln Pro Arg 
            260                 265                 270         


Asp Tyr Gly Leu Asp Pro Lys Val Lys Gly Gly Ile Asp Ile Gly Leu 
        275                 280                 285             


Ser Ser Pro Leu Val Cys Ala Val Thr Asn Ser Leu Ala Arg Leu Thr 
    290                 295                 300                 


Ile Arg Asp Asn Asp Leu Val Ala Phe Asn Arg Lys Ala Met Ala Arg 
305                 310                 315                 320 


Arg Arg Thr Leu Leu Arg Gln Asn Arg Tyr Lys Arg Ser Gly His Gly 
                325                 330                 335     


Ser Ala Asn Lys Leu Lys Pro Ile Glu Ala Leu Thr Glu Lys Asn Glu 
            340                 345                 350         


Leu Tyr Arg Lys Ala Ile Met Arg Arg Trp Ala Arg Glu Ala Ala Asp 
        355                 360                 365             


Phe Phe Arg Gln His Arg Ala Ala Thr Val Asn Met Glu Asp Leu Thr 
    370                 375                 380                 


Gly Ile Lys Asp Arg Glu Asp Tyr Phe Ser Gln Met Leu Arg Cys Tyr 
385                 390                 395                 400 


Trp Asn Tyr Ser Gln Leu Gln Thr Met Leu Glu Asn Lys Leu Lys Glu 
                405                 410                 415     


Tyr Gly Ile Ala Val Lys Tyr Ile Glu Pro Lys Asp Thr Ser Lys Thr 
            420                 425                 430         


Cys His Ser Cys Gly His Val Asn Glu Tyr Phe Asp Phe Asn Tyr Arg 
        435                 440                 445             


Ser Ala His Lys Phe Pro Met Phe Lys Cys Glu Lys Cys Gly Val Glu 
    450                 455                 460                 


Cys Gly Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Gln Ala 
465                 470                 475             


<210>  231
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.294655

<400>  231

Met Pro Phe Lys Val Leu Lys Leu Lys Ile Ile Lys Pro Val Asn Met 
1               5                   10                  15      


Asp Trp Asn Glu Leu Gly Gln Ser Ile Arg Asp Thr Arg Tyr Arg Val 
            20                  25                  30          


Tyr Arg Leu Ala Asn Leu Ala Val Ser Glu Ala Tyr Leu Ala Phe His 
        35                  40                  45              


Leu Trp Arg Ala Gly Lys Thr Asp Ala Ile Pro Lys Ala Thr Ala Gly 
    50                  55                  60                  


Gln Leu Asn Arg Arg Leu Arg Asp Met Leu Leu Glu Glu Ala Arg Thr 
65                  70                  75                  80  


Lys Ala Val Lys Asp Arg Lys Asn Thr Gly Glu Lys Gly Thr Glu Asp 
                85                  90                  95      


Asp Ala Lys Lys Ala Gln Lys Glu Met Asn Lys Phe Ser Lys Thr Gly 
            100                 105                 110         


Ala Leu Pro Asp Thr Val Ala Gly Ala Leu Phe Met Tyr Lys Val Lys 
        115                 120                 125             


Gly Leu Ile Ser Lys Gly Lys Trp Thr Gln Val Ile Arg Gly Lys Ser 
    130                 135                 140                 


Ala Leu Pro Thr Phe Arg Asn Asn Met Ala Ile Pro Ile Arg Cys Asp 
145                 150                 155                 160 


Lys Lys Thr Gln Arg Arg Leu Glu Arg Thr Glu Asn Gly Val Glu Leu 
                165                 170                 175     


Glu Leu Met Ile Arg Asn Lys Pro Tyr Pro Arg Val Leu Leu Gly Thr 
            180                 185                 190         


Gln Gly Ile Gly Glu Gly Ala Glu Ala Ile Ile Glu Arg Leu Leu Ser 
        195                 200                 205             


Asn Glu Ser Gln Ala Glu Gln Gly Tyr Lys Gln Arg Tyr Phe Glu Val 
    210                 215                 220                 


Arg Glu Asp Val Asn Arg Thr Trp Trp Leu Tyr Val Cys Tyr Ala Leu 
225                 230                 235                 240 


Pro Ala Ser Thr Pro Pro Arg Leu Asp Pro Ser Lys Ile Val Gly Val 
                245                 250                 255     


Asp Leu Gly Phe Thr Cys Pro Met Tyr Ala Ala Ile Ser Asn Gly His 
            260                 265                 270         


Ala Arg Leu Gly Tyr Arg Ala Phe Ser Ser Leu Ala Ala Arg Val Lys 
        275                 280                 285             


Ala Leu Lys Leu Arg Thr Met Arg Arg Arg Arg Glu Ile Gln Arg Gly 
    290                 295                 300                 


Gly Arg Thr Ile Val Ser Gly Glu Ala Ala Arg Ser Gly His Gly Arg 
305                 310                 315                 320 


Lys Arg Lys Leu Leu Gly Ile Glu Lys Leu Gln Gly Arg Val Asn Gln 
                325                 330                 335     


Ala Tyr Thr Thr Leu Asn His Gln Met Ser Ala Ala Val Val Lys Phe 
            340                 345                 350         


Ala Ile Glu Asn Gly Ala Gly Thr Ile Gln Val Glu Asn Leu Glu Gly 
        355                 360                 365             


Leu Arg Glu Glu Leu Ser Gly Thr Phe Leu Gly Gln Met Trp Arg Tyr 
    370                 375                 380                 


Phe Gln Leu Gln Glu Phe Leu Gln Tyr Lys Ala Glu Glu Asn Gly Ile 
385                 390                 395                 400 


Val Ile Arg Lys Val Asn Pro Arg Tyr Thr Ser Arg Arg Cys Ser Gln 
                405                 410                 415     


Cys Gly His Ile Asn Lys Glu Phe Thr Arg Lys Ala Arg Asp Arg Asn 
            420                 425                 430         


Ala Glu Gly Gly Tyr Ser Ala Lys Phe Lys Cys Pro Asp Cys Glu Tyr 
        435                 440                 445             


Glu Ala Asp Ala Asp Tyr Asn Ala Ala Lys Asn Leu Ala Val Asp Gly 
    450                 455                 460                 


Ile Glu Gly Ile Ile Glu Lys Gln Cys Gly Ser Gln Gly Ile Val Leu 
465                 470                 475                 480 


<210>  232
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.295201

<400>  232

Met Phe Leu Tyr Lys Glu Leu Lys Thr Met Ala Lys Thr Asn Ala Glu 
1               5                   10                  15      


Glu Gly Lys Ile Glu Asn Lys Glu Lys Arg Leu Thr Lys Val Ala Lys 
            20                  25                  30          


Phe Gln Ile Val Lys Pro Val Asn Met Thr Trp Pro Glu Phe Gly Lys 
        35                  40                  45              


Met Leu Gly Asp Val Arg Tyr Arg Leu Ser Arg Val Ala Asn Met Ala 
    50                  55                  60                  


Val Thr Glu Lys Tyr Leu Glu Ser Gln Gln Lys Arg Thr Gly Gln Lys 
65                  70                  75                  80  


Ile Gln Arg Glu Asn Thr Leu Val Thr Ile Ala Asn Arg Lys Leu Arg 
                85                  90                  95      


Glu Met Leu Lys Lys Glu Lys Val Lys Glu Glu Glu Leu Asp Arg Tyr 
            100                 105                 110         


Ser Arg Asp Gly Ala Val Ser Gly Tyr Val Thr Gly Pro Phe Glu His 
        115                 120                 125             


Asn Lys Leu Ser Ala Ile Ser Lys Arg Phe Lys Glu Val Leu Lys Gly 
    130                 135                 140                 


Asn Met Ser Leu Pro Asn Phe Lys Arg Glu Met Ala Ile Pro Ile Asn 
145                 150                 155                 160 


Cys Ser Asn Ala Lys Leu Ser Thr Ile Glu Lys Thr Glu Thr Gly Glu 
                165                 170                 175     


Tyr Val Val Asp Leu Arg Ile Ser Gln Lys Pro Trp Pro Arg Val Leu 
            180                 185                 190         


Leu Ser Thr Asn Arg Ile Ser Asn Gly Gln Arg Glu Ile Leu Glu Arg 
        195                 200                 205             


Leu Ala Ala Asn Lys Thr Phe Ser Asp Asp Gly Tyr Lys His Leu Phe 
    210                 215                 220                 


Phe Glu Val Lys Gln Gln Gly Lys Asp Trp Phe Leu Ser Val Thr Tyr 
225                 230                 235                 240 


Ser Phe Pro Lys Ser Glu Ala Pro Lys Leu His Lys Asp Ile Ile Val 
                245                 250                 255     


Gly Val Asp Leu Gly Trp Ser Val Pro Leu Tyr Ala Ala Val Asn Lys 
            260                 265                 270         


Gly Tyr Ala Arg Ile Gly Trp Gln Lys Phe Arg Pro Leu Ala Glu Arg 
        275                 280                 285             


Ile Lys His Leu Gln Lys Gln Val Lys Ala Arg Arg Ile Thr Ile Gln 
    290                 295                 300                 


Lys Gly Gly Gln Gln Asp Leu Ala Thr Pro Thr Ala Arg Thr Gly His 
305                 310                 315                 320 


Gly Arg Lys Arg Ile Leu Arg Pro Ile Glu Lys Leu Glu Arg Lys Ile 
                325                 330                 335     


Glu Asn Ala Tyr Thr Thr Leu Asn His Gln Leu Ser His Cys Val Ile 
            340                 345                 350         


Glu Phe Ala Lys Asn Asn Gly Ala Gly Val Ile Gln Ile Glu Asn Leu 
        355                 360                 365             


Ser Gly Leu Ala Asn Glu Leu Ser Gly Thr Tyr Ile Gly Gln Asn Trp 
    370                 375                 380                 


Arg Tyr Glu Gln Leu Gln Glu Tyr Ile Arg Tyr Lys Ala Glu Glu Ala 
385                 390                 395                 400 


Gly Ile Glu Val Lys His Val Asn Pro Cys Arg Thr Ser Gln Arg Cys 
                405                 410                 415     


Ser Glu Cys Gly Phe Ile Asn Asp Lys Phe Asn Phe Glu Tyr Arg Gln 
            420                 425                 430         


Ala Asn Arg Asn Asn Gly Met Ser Ala Met Phe Glu Cys Pro Glu Cys 
        435                 440                 445             


Lys Lys Asn Lys Lys Asp Tyr Lys Pro Ile Asn Ala Asp Tyr Asn Ala 
    450                 455                 460                 


Ala Lys Asn Leu Thr Thr Ala Asn Ile Asp Glu Ile Ile Arg Leu Gln 
465                 470                 475                 480 


Cys Lys Lys Gln Gly Ile Glu Tyr Lys Glu Leu Pro Lys Asp 
                485                 490                 


<210>  233
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.296640

<400>  233

Met Ser Lys Ile Thr Arg Lys Ile Glu Leu Ile Pro Asp Ile Glu Asn 
1               5                   10                  15      


Leu Thr His Glu Glu Ser Asn Gln Arg Cys Tyr Lys Val Phe Tyr Asn 
            20                  25                  30          


Ile Asp Asn Lys Leu Tyr Lys Val Ala Asn Leu Leu Val Cys Gln Leu 
        35                  40                  45              


Phe Gly Leu Asp Asn Leu Leu Ser Leu Met Arg Leu Gln Asn Asp Glu 
    50                  55                  60                  


Tyr Val Lys Cys Gln Ser Lys Leu Ala Ser Lys Ser Ile Ser Glu Glu 
65                  70                  75                  80  


Thr Lys Arg Asp Ile Lys Lys Arg Met Glu Ala Ile Asp Lys Glu Leu 
                85                  90                  95      


Leu Ala Arg Lys Asp Glu Ile Ala Pro Lys His Pro Gln Thr Phe Ala 
            100                 105                 110         


Tyr Arg Ala Ile Lys Asp Ser Asp Tyr Ala Lys Asp Leu Pro Ser Asp 
        115                 120                 125             


Ile Phe Asn Thr Leu Lys Gln Asp Val Phe Lys His Phe Asn Glu Thr 
    130                 135                 140                 


Lys Lys Glu Gln Leu Arg Gly Glu Arg Ser Leu Thr Thr Tyr Lys Arg 
145                 150                 155                 160 


Gly Ile Pro Val Pro Phe Asn Leu Met Lys Lys Asn Val Ile Val Ser 
                165                 170                 175     


Asp Gly Asp Asn Tyr Tyr Leu Thr Trp Phe Glu Glu Thr Arg Phe Lys 
            180                 185                 190         


Leu Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg Ala Ile Ile Asp Asn 
        195                 200                 205             


Cys Leu Lys Thr Asn Lys Tyr Lys Leu Cys Thr Ala Ala Lys Ile Gln 
    210                 215                 220                 


Leu Lys Asn Lys Lys Leu Phe Leu Leu Val Thr Val Asp Ile Pro Glu 
225                 230                 235                 240 


Thr Lys Asn Lys Ile Ile Lys Gly Lys Val Met Gly Val Asp Leu Gly 
                245                 250                 255     


Val Val His Pro Ala Tyr Val Ala Val Asn Asp Gly Pro Glu Arg Ser 
            260                 265                 270         


Leu Ile Gly Asp Gly Asp Ala Phe Gln Lys Gln Arg Asp Val Phe Arg 
        275                 280                 285             


Arg Arg Phe Arg Glu Leu Gln Arg Cys Gln Leu Thr Gln Gly Gly His 
    290                 295                 300                 


Gly Arg Lys His Lys Thr Lys Ala Thr Glu Asn Leu Arg Gly Lys Glu 
305                 310                 315                 320 


Arg Asn Trp Val Gln Thr Glu Asn His Arg Ile Ser Arg Glu Ile Val 
                325                 330                 335     


Asn Leu Ala Ile Arg Trp Arg Val Glu Thr Ile Gln Met Glu Asn Leu 
            340                 345                 350         


Lys Gly Phe Gly Lys Asp Ser Asp Gly Asp Val Glu Thr Lys His Gln 
        355                 360                 365             


Arg Leu Leu Gly Arg Trp Ser Tyr Phe Glu Leu Gln Lys Asp Ile Glu 
    370                 375                 380                 


Tyr Lys Ala Ala Met Ala Gly Ile Lys Val Val Tyr Val Asn Pro Ala 
385                 390                 395                 400 


Tyr Thr Ser Gln Thr Cys His Val Cys Gly Glu Arg Gly Asp Arg Thr 
                405                 410                 415     


Glu Arg Asp Thr Phe Ile Cys Thr Asn Thr Glu Cys Asp Cys Tyr Gly 
            420                 425                 430         


Lys Pro Gln Asp Ala Asp Met Asn Ala Ala Ile Asn Ile Ala Arg Ser 
        435                 440                 445             


Lys Asn Ile Val Lys 
    450             


<210>  234
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.296642

<400>  234

Met Thr Lys Val Val Lys Leu Pro Leu Ile Cys Glu Gln Ser Asp Lys 
1               5                   10                  15      


Asp Gly Asn Pro Ile Asp Tyr Lys Lys Ile Tyr Glu Ile Leu Phe Glu 
            20                  25                  30          


Leu Gln Arg Gln Thr Arg Glu Ile Lys Asn Lys Ser Ile Gln Tyr Cys 
        35                  40                  45              


Trp Glu Phe Ser Asn Phe Ser Ser Asp Tyr Tyr Lys Gln Asn His Glu 
    50                  55                  60                  


Tyr Pro Lys Glu Lys Asp Ile Leu Ser Tyr Thr Leu Val Gly Phe Val 
65                  70                  75                  80  


Asn Asp Lys Phe Lys Thr Gly Asn Asp Leu Tyr Ser Gly Asn Cys Ser 
                85                  90                  95      


Thr Thr Val Arg Gly Ala Cys Gly Glu Phe Lys Asn Ser Lys Thr Asp 
            100                 105                 110         


Phe Leu Lys Gly Thr Lys Ser Ile Ile Asn Tyr Lys Gly Asn Gln Pro 
        115                 120                 125             


Leu Asp Leu His Asn Lys Thr Ile Arg Phe Glu Cys Ile Gly Lys Asp 
    130                 135                 140                 


Tyr Tyr Ala Tyr Leu Lys Leu Leu Asn Arg Pro Ala Phe Gln Arg Asn 
145                 150                 155                 160 


Asn Phe Ser Ser Ser Glu Ile Lys Phe Lys Val Leu Val Tyr Asp Asn 
                165                 170                 175     


Ser Ser Lys Thr Ile Val Glu Arg Cys Ile Asp Asn Ile Tyr Lys Ile 
            180                 185                 190         


Ser Ala Ser Lys Leu Ile Tyr Asn Glu Lys Lys Lys Cys Trp Val Leu 
        195                 200                 205             


Asn Leu Ser Tyr Ser Phe Thr Asn Asn Asn Val Cys Glu Leu Asp Glu 
    210                 215                 220                 


Asn Lys Ile Leu Gly Val Asp Leu Gly Ile His Tyr Pro Ile Cys Ala 
225                 230                 235                 240 


Ser Val Asn Gly Glu Arg Lys Phe Phe Lys Ile Asp Gly Gly Glu Ile 
                245                 250                 255     


Asp His Thr Arg Arg Lys Ile Glu Val Arg Lys Lys Ser Leu Leu Lys 
            260                 265                 270         


Gln Gly Ser Ser Cys Gly Glu Gly Arg Ile Gly His Gly Ile Lys Thr 
        275                 280                 285             


Arg Asn Lys Pro Val Tyr Asn Ile Glu Asp Lys Ile Ala Cys Phe Arg 
    290                 295                 300                 


Asp Thr Ala Asn His Lys Tyr Ser Arg Ala Leu Ile Asn Tyr Ala Val 
305                 310                 315                 320 


Asn Asn Asn Cys Gly Ile Ile Gln Met Glu Lys Leu Thr Gly Ile Thr 
                325                 330                 335     


Ala Asp Ser Asp Arg Phe Leu Lys Asn Trp Ser Tyr Phe Asp Leu Gln 
            340                 345                 350         


Thr Lys Ile Glu Tyr Lys Ala Lys Glu Ala Gly Ile Thr Val Val Tyr 
        355                 360                 365             


Ile Asp Pro Gln Tyr Thr Ser Gln Arg Cys Ser Lys Cys Gly Tyr Ile 
    370                 375                 380                 


Ser Lys Glu Asn Arg Lys Val Gln Ala Lys Phe Cys Cys Gln Lys Cys 
385                 390                 395                 400 


Gly Tyr Glu Ala Asn Ala Asp Tyr Asn Ala Ser Gln Asn Ile Gly Ile 
                405                 410                 415     


Lys Asp Ile Asp Lys Ile Ile Lys Asn Thr Lys 
            420                 425         


<210>  235
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.298142

<400>  235

Val Pro Ile Thr Lys Thr Ile Ser Leu Arg Ile Leu Arg Pro Tyr Tyr 
1               5                   10                  15      


Pro Pro Glu Ile Glu Ala Lys Ile Lys Ala Glu Lys Glu Lys Arg Lys 
            20                  25                  30          


Glu Asn Gly Asp Thr Gly Ser Leu Asn Ser Ser Tyr Tyr Arg Glu Leu 
        35                  40                  45              


Lys Lys Glu Tyr Pro Ser Ile Ile Ile Asn Asp Glu Phe Phe Pro Leu 
    50                  55                  60                  


Leu Ser Glu Met Gln Arg Asn Ile Thr Ser Ile Tyr Asn Arg Thr Ile 
65                  70                  75                  80  


Ser His Leu Tyr His Arg Leu Ile Ile Lys Lys Glu Ser Ile Ser Thr 
                85                  90                  95      


Ala Lys Ala Leu Ser Glu Gly Pro Tyr Arg Asp Phe Lys Ser Thr Phe 
            100                 105                 110         


Asn Ser Tyr Ile Ala Leu Gly Leu Arg Gln Lys Val Gln Ser Asn Phe 
        115                 120                 125             


Arg Lys Lys Asp Leu Met Ala Phe Lys Ile Ala Leu Pro Thr Ala Lys 
    130                 135                 140                 


Ser Asp Lys Phe Pro Ile Pro Ile Tyr Met Gln Thr Asn Phe Lys Ile 
145                 150                 155                 160 


Lys Glu Ser Pro Asp Ser Asp Phe Ile Ile Glu Leu Pro Leu Val Glu 
                165                 170                 175     


Tyr Ile Ala Lys Glu Thr Lys Gly Lys Asn Lys Met Phe Thr Lys Val 
            180                 185                 190         


Glu Ile Leu Ser Pro Pro Lys Val Lys Asn Ile Pro Val Ile Leu Ser 
        195                 200                 205             


Thr Arg Arg Arg Lys Glu Ser Gly Gln Trp Phe Ser Asp Glu Gly Thr 
    210                 215                 220                 


Asn Ala Glu Ile Arg Arg Ile Ile Ser Gly Glu Tyr Lys Val Ser Trp 
225                 230                 235                 240 


Ile Glu Ile Val Lys Arg Thr Arg Phe Gly Lys His Asp Trp Phe Val 
                245                 250                 255     


Asn Met Val Ile Ser Phe Glu Glu Ser Gln Glu Gly Leu Asp Pro Asp 
            260                 265                 270         


Val Ile Gly Gly Ile Asp Ile Gly Val Ser Lys Pro Leu Ile Cys Ala 
        275                 280                 285             


Ile Asn Asn Ser Leu Asp Arg Tyr Ile Val Lys Gly Asp Asp Ile Ile 
    290                 295                 300                 


Ala Phe Asn Arg Arg Ala Leu Ser Arg Arg Arg Ser Leu Leu Arg Arg 
305                 310                 315                 320 


Asn Arg Leu Lys Arg Ser Gly His Gly Ser Arg Asn Lys Leu Glu Pro 
                325                 330                 335     


Ile Thr Val Leu Thr Glu Lys Asn Glu Arg Phe Lys Lys Ser Ile Met 
            340                 345                 350         


Gln Arg Trp Ala Lys Glu Val Ala Glu Phe Phe Lys Ser Lys Arg Ala 
        355                 360                 365             


Ser Ile Val Gln Met Glu Glu Leu Thr Gly Ile Lys Glu Arg Glu Asp 
    370                 375                 380                 


Phe Phe Ser Lys Thr Leu Arg Met Tyr Trp Asn Tyr Gly Gln Leu Gln 
385                 390                 395                 400 


Lys Thr Val Glu Asn Lys Leu Arg Glu Tyr Gly Ile Glu Val Arg Tyr 
                405                 410                 415     


Ala Ser Pro Lys Asp Thr Ser Arg Arg Cys His Ser Cys Gly His Ile 
            420                 425                 430         


Asn Asp Tyr Phe Thr Phe Glu Phe Arg Gln Gln Asn Asn Phe Pro Leu 
        435                 440                 445             


Phe Lys Cys Met Asn Cys Gly Ile Glu Cys Ser Ala Asp Tyr Asn Ala 
    450                 455                 460                 


Ala Arg Asn Ile Ala Ile Ala Arg 
465                 470         


<210>  236
<211>  1331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.298248

<400>  236

Met Asn Arg Ile Tyr Gln Gly Arg Val Ser Lys Val Glu Ile Pro Asp 
1               5                   10                  15      


Gly Lys Asp Glu Trp Lys Lys Leu Asp Asp Gly Glu Ser Ala Leu Trp 
            20                  25                  30          


Gln His His Gln Leu Phe Gln Asp Asp Val Asn Tyr Leu Leu Ala Ala 
        35                  40                  45              


Phe Ala Ala Leu Val Pro Thr Ser Cys Glu Asp Asp Ile Trp Lys Asp 
    50                  55                  60                  


Tyr Gln Ala Ala Ile Glu Arg Ser Trp Glu Ser Tyr Thr Gly Arg Gln 
65                  70                  75                  80  


Gly Ile Trp Asp Arg Pro Phe Glu Asn Ala Cys Val Ile Val Gly Cys 
                85                  90                  95      


Lys Lys Asp Ala Ser Phe Lys Glu Phe Arg Arg Lys Leu Asn Ser Leu 
            100                 105                 110         


Thr Gly Ser Lys Ala Ser Glu Lys Gln Lys Phe Glu Ala Leu Lys Gln 
        115                 120                 125             


Leu Phe Glu Pro Ala Thr Glu Ala Ala Lys Lys Leu Lys Lys His Asp 
    130                 135                 140                 


Glu Pro Val Glu Glu Ser Leu Lys Gly Lys Ala Lys Asp Leu Phe Gly 
145                 150                 155                 160 


Ser Thr Leu Val Asn Leu Cys Ala Gln Lys Thr Lys Val Thr Pro Arg 
                165                 170                 175     


Asp Val Ile Ala Lys Gln Arg Asn Arg Ala Ser Glu Cys Thr Lys Lys 
            180                 185                 190         


Val Asn Glu Gly Glu Arg Leu Lys Trp Ala Asp Val Phe Tyr Phe Lys 
        195                 200                 205             


Thr Asp Thr Ser Ala Ala Lys Trp Ser Arg Glu Asp Ala Ala Lys Asn 
    210                 215                 220                 


Ile Ile Gln Phe Leu Asp Lys Leu Leu Gly Glu Val Glu Glu Lys Glu 
225                 230                 235                 240 


Lys Asp Ala Lys Thr Ser Asp Gln Lys Lys Lys Met Ala Asp Leu Ala 
                245                 250                 255     


Glu Arg Leu Glu Lys Gln Lys Lys Pro Leu Ala Ala Trp Cys Asn Asn 
            260                 265                 270         


Ser Lys Thr Asp Leu Pro Thr Thr Glu Pro Thr Arg Lys Gly Ser Gly 
        275                 280                 285             


Gly Tyr Asp Leu Lys Ala Ala Val Leu Phe Ser Leu Gln Pro Asp Leu 
    290                 295                 300                 


Asp Gly Phe Arg Asp Ala Phe Leu Leu Phe Asn Gln Ala Arg Leu Lys 
305                 310                 315                 320 


Glu Glu Phe Ala Thr Thr Glu Lys Gly Asp Ala Ala Tyr Ile Ala Arg 
                325                 330                 335     


Met Ala Gly Gly Val Ala Arg Pro Val Phe Pro Phe Phe Cys Asp Val 
            340                 345                 350         


Trp Ala Gly Lys Val Asn Asp Glu Lys Ile Gly Gln Gly Ile Trp Pro 
        355                 360                 365             


Asp Phe Glu Lys Gln Ala Phe Ser Glu Val Phe Thr Lys Ile Gly Gln 
    370                 375                 380                 


Phe Ile Val Arg Gly Arg Lys Phe Glu Leu Arg Leu Ala Ile Ala Asp 
385                 390                 395                 400 


Gln Ile Ile Ala Lys Ile Glu Thr Gln Lys Lys Ser Asp Ala Arg Leu 
                405                 410                 415     


Gln Ala Val Glu Arg Ile Ala Glu Asp Leu Ala Asp Glu Leu Pro Asp 
            420                 425                 430         


Thr Ala Val Asp Glu Asn Gly Gln Lys Arg Pro Tyr Gly Ile Arg Glu 
        435                 440                 445             


Arg Thr Leu Lys Gly Trp Arg Lys Val Arg Pro Ala Trp Arg Glu Ala 
    450                 455                 460                 


Leu Lys Lys Thr Pro Asn Leu Thr Ala Glu Asp Leu Ile Lys Gln Lys 
465                 470                 475                 480 


Asn Arg Met Gln Glu Arg Gln Arg Glu Lys Tyr Gly Ser Ala Ser Leu 
                485                 490                 495     


Phe Asp Arg Leu Ala Lys Glu Pro Glu Ile Trp Asn His Asp Asp Lys 
            500                 505                 510         


Glu Asp Ala Val Glu Thr Trp Ala Asp Tyr Val Glu Asn Leu Glu Glu 
        515                 520                 525             


Lys Ala His Leu Glu Thr Glu Arg Leu Phe Ala Pro Ala His Ala Thr 
    530                 535                 540                 


Leu Ser Pro Arg Phe Phe Arg Trp Ser Glu Thr Asn Asn Lys Glu His 
545                 550                 555                 560 


Leu Glu Ala Ser Ser Pro Asp Val Pro Phe Glu Leu Lys Ala Asp Ala 
                565                 570                 575     


Leu Asp Leu Ser Lys Lys Glu Lys Ser Gln Ile Lys Ile His Phe Trp 
            580                 585                 590         


Ser Pro Arg Leu Trp Arg Asp Gly Leu Arg Gly Lys Lys Glu Asn Leu 
        595                 600                 605             


Asp Lys Asp Glu Pro Asp Gln Asn Trp Met Pro Pro Val Leu Arg Ala 
    610                 615                 620                 


Phe Val Lys Ala Arg Lys Trp Pro Cys Asp Lys Gln Ser Phe Ala Gly 
625                 630                 635                 640 


Ala Ser Val Arg Leu Ala Pro Arg Cys Lys Glu Asn Ile Gln Leu Val 
                645                 650                 655     


Phe Glu Pro Glu Leu His Thr Glu Ile Leu Ser Ala Lys Trp Lys Glu 
            660                 665                 670         


Asn Phe Pro Phe Ser Pro Ala Lys Asn Lys Glu Ser Glu Ser Val Gly 
        675                 680                 685             


Leu Phe Trp Pro Arg Thr Lys Glu Asp Lys Val Leu Trp Phe Asp Lys 
    690                 695                 700                 


Gly Glu Thr Arg Cys Leu Gly Val Asp Leu Gly Leu Thr Asn Ser Ala 
705                 710                 715                 720 


Ala Trp Gln Ile Leu Gln Ala Thr Asn Lys Asp Ala Thr Ala Lys Ala 
                725                 730                 735     


Pro Arg Leu Arg His Arg Leu Asn Pro Asp Ser Glu Lys Ala Ala Trp 
            740                 745                 750         


Phe Ala His Ser Ile Thr Asn Gly Ile Val Arg Val Ala Gly Glu Asp 
        755                 760                 765             


Cys Trp Gly Trp Arg Lys Phe Ala Pro Asp Glu Lys Ala Lys Leu Arg 
    770                 775                 780                 


Ala Glu Leu Lys Lys Pro Ala Gly Lys Arg Asn Ala Leu Cys Arg Lys 
785                 790                 795                 800 


Phe Leu Ser Leu Asn Arg Glu Ile Glu Phe Glu Thr Ala Thr His Ser 
                805                 810                 815     


Phe Leu Pro Glu Leu Ser Gly Ser Gly Gly Arg Asn Pro Thr Asp Asp 
            820                 825                 830         


Glu Thr Lys Glu Ala Ala Glu Phe Phe Ser Thr Leu Lys Thr Lys Gly 
        835                 840                 845             


Phe Asp Ile Thr Asp Arg Gln Pro Ser Trp Gly Lys Asn Leu Ser Phe 
    850                 855                 860                 


Pro Lys Gln Asn Asp Glu Leu Leu Trp Gly Leu Lys Arg Val Arg Ala 
865                 870                 875                 880 


Gln Leu Phe Arg Leu Asn Arg Trp Ser Glu Gln Leu Gly Lys Glu Arg 
                885                 890                 895     


Asp Ser Lys Pro Tyr Gln Ser Ala Ile Glu Ile Ile Gly Asn Leu Arg 
            900                 905                 910         


Ser Asp Asp Pro Leu Ile Glu Leu Ala Thr Leu Lys Ser Glu Pro Lys 
        915                 920                 925             


Arg Leu Lys Ser Arg Ile Ala Glu Leu Ala Gly Glu Tyr Leu Asp Cys 
    930                 935                 940                 


Phe Lys Thr Leu Leu Pro Arg Ile Ala Asp Arg Ile Leu Pro Trp Arg 
945                 950                 955                 960 


Arg Gly His Trp Ser Trp Lys Pro Cys Asp Asn Asp Trp His Arg Met 
                965                 970                 975     


Glu Leu Asp Ala Ser Lys Pro Arg Pro Glu Ala Leu Leu Ala Gly Gln 
            980                 985                 990         


Arg Gly Ile Ser Leu Pro Arg Leu  Asn Gln Leu Lys Asp  Leu Arg Gln 
        995                 1000                 1005             


Leu Ala  Gln Ser Leu Asn His  Leu Cys Arg Arg Lys  Gln Ile Lys 
    1010                 1015                 1020             


Arg Asn  Glu Thr Val Pro Glu  Pro Phe Glu Asp Cys  Arg Gln Ala 
    1025                 1030                 1035             


Met Glu  Asp Ala Arg Glu Asp  Arg Ala Lys Lys Ile  Ala His Glu 
    1040                 1045                 1050             


Val Phe  Ala Ile Ala Leu Gly  Val Glu Leu Ala Pro  Pro Pro Pro 
    1055                 1060                 1065             


Asp Lys  Gln Glu Arg Lys Gln  Thr Glu Ser Leu His  Gly Val Tyr 
    1070                 1075                 1080             


Arg Cys  Leu Glu Arg Gly Pro  Val Asn Phe Ile Ala  Leu Glu Asn 
    1085                 1090                 1095             


Leu Gly  Gly Tyr Asn Pro Ser  Ala Lys Gln Gly Arg  Arg Glu Asn 
    1100                 1105                 1110             


Arg Gln  Leu Ser Ser Trp Leu  Lys Gly Arg Ile His  Lys Ile Leu 
    1115                 1120                 1125             


Gly Glu  Leu Cys Glu Met Val  Gly Met Pro Ile Val  Leu Val Asn 
    1130                 1135                 1140             


Ala Glu  Tyr Thr Ser Arg Phe  Ser Ala Lys Asp His  Ser Pro Gly 
    1145                 1150                 1155             


Phe Arg  Ala Glu Glu Val Gln  Thr Asp Asp Ser Arg  Arg Ser Phe 
    1160                 1165                 1170             


Trp Gln  Arg Lys Ala Lys Glu  Glu Pro Ser Gly Trp  Gln Asn Glu 
    1175                 1180                 1185             


Phe Leu  Cys Trp Leu Asn Lys  Val Pro Asp Gly Lys  Ser Leu Leu 
    1190                 1195                 1200             


Leu Pro  Lys Lys Gly Gly Glu  Phe Phe Val Pro Leu  Gly Glu Gly 
    1205                 1210                 1215             


Thr Ser  Leu Tyr His Ala Asp  Leu Asn Ala Ala Tyr  Arg Ile Ala 
    1220                 1225                 1230             


Leu Arg  Ala Leu Ala His Arg  Asp Arg Ala Glu Leu  Leu Gly Gln 
    1235                 1240                 1245             


Thr Trp  Ile Glu Lys Lys Pro  Tyr Leu Val Asp Val  Ala Gly Val 
    1250                 1255                 1260             


Phe Pro  Asp Ser Ile Leu Arg  Asn Gly Cys Ala Phe  Lys Thr Ile 
    1265                 1270                 1275             


Ser Ser  Ser Glu Arg Leu Trp  Glu Lys Val Asn Gly  Asp Leu Ala 
    1280                 1285                 1290             


Met Gln  Arg Cys Arg Glu Ile  Asn Leu Ala Arg Phe  Ala Ser Trp 
    1295                 1300                 1305             


Lys Ile  Ala Leu Pro Gln Gln  Ile Ile Ser Glu Ala  Leu Pro Pro 
    1310                 1315                 1320             


Asp Glu  Glu Asp Asp Ile Pro  Met 
    1325                 1330     


<210>  237
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.298264

<400>  237

Met Ser Glu Ala Thr Lys Thr Leu Ala Tyr Arg Tyr Arg Leu Arg Leu 
1               5                   10                  15      


Thr Pro Ala Gln Glu Asp Ile Leu Asp Arg Ser Gln Glu Gln Leu Arg 
            20                  25                  30          


Leu Val Trp Asn His Leu Val Arg Ser Gln His Lys Val Glu His Glu 
        35                  40                  45              


Trp Arg His Gly Arg Ala Ala Ser Ile Lys Asn Glu Leu Leu Glu Leu 
    50                  55                  60                  


Ser Leu Ala Lys Asn Ala Thr Gly Gln Ala Ile Pro Ser Ala Arg Lys 
65                  70                  75                  80  


Ile Thr Glu Glu Arg Gly Val Ser Met Glu Glu Ala Leu Arg Leu Met 
                85                  90                  95      


Arg Gln Lys Phe Val Glu Lys Val Ser Ala Ile Pro Leu Arg Lys Lys 
            100                 105                 110         


Asp Gly Ser Arg Cys Leu Arg Ile Ala Arg Arg Lys Met Ala Thr Glu 
        115                 120                 125             


Tyr Ala Val Thr Val Val Asn Ala Lys Phe Lys His Tyr Tyr Gly Leu 
    130                 135                 140                 


Gly Ala Arg Met Cys Lys Val Leu Arg Asp Lys Phe Gln Lys Cys Ser 
145                 150                 155                 160 


Asp Met Trp Ile Lys Gly Lys Phe Arg Arg Pro Arg Phe Lys Arg Lys 
                165                 170                 175     


Gly Glu Ser Val Ala Leu Gln Arg Gln Val Gln Ser Asn Ser Pro Phe 
            180                 185                 190         


Lys Leu Lys Arg Phe Ser Asp Leu Ser Ala Leu Gly Gly Gln Ala Leu 
        195                 200                 205             


Lys Lys Cys Glu Val Ile Ile His Arg Pro Leu Pro Asp Ser Ala Glu 
    210                 215                 220                 


Ile Lys Gln Ile Ala Val Ser Gly Arg Arg Gly Gln Arg His Leu Ile 
225                 230                 235                 240 


Val Met Phe Lys Ala Ala Ser Ser Asp Val Ala Lys Asn Phe Pro Ala 
                245                 250                 255     


Thr Asn Arg Thr Ala Gly Val Asp Pro Gly Ile Lys Val Ala Leu Thr 
            260                 265                 270         


Ile Thr Pro Leu Asp Ser Pro Asp Phe Gly Thr Ser Asp Lys Ile Glu 
        275                 280                 285             


Lys Gln Pro Asp Leu Ala Arg Asp Ala Cys Phe Leu Lys Arg Leu Arg 
    290                 295                 300                 


Arg Leu Gln Arg Lys His Asp Arg Gln Arg Arg Gln Asn Asn Pro Glu 
305                 310                 315                 320 


Cys Phe Asp Glu Lys Gly Arg Trp Ile Lys Gly Lys Arg Leu His Asn 
                325                 330                 335     


Glu Ser Lys Asn Met Gln Arg Thr Gln Ser Arg Ile Thr Ala Met Asn 
            340                 345                 350         


Thr His Leu Ala Glu Ser Arg Arg Asp Phe Tyr His Asn Ala Ala Cys 
        355                 360                 365             


Glu Ile Leu Arg Ser Phe Asp Asn Val Ala Val Gly Lys Trp Arg Pro 
    370                 375                 380                 


Ala Gln Thr Arg Gln Arg Lys Pro Thr Thr Pro Ser Pro Lys Gly Leu 
385                 390                 395                 400 


Gly Ala Ala Arg Arg Ala Thr Asn Arg Ile Ser Tyr Asp His Ala Ile 
                405                 410                 415     


Ser Leu Phe Ile Ser Tyr Leu Lys Asp Lys Ala Glu Arg Ser Val Thr 
            420                 425                 430         


Thr Lys His Val Gln Glu Val Ser Glu Phe Gly Ser Thr Arg Ser Cys 
        435                 440                 445             


Pro Lys Cys Gly Lys Leu Thr Gly Pro Val Gly Thr Glu Gly Leu Ala 
    450                 455                 460                 


Val Arg Asp Trp Thr Cys Val Asn Cys Asn Thr Thr Phe Gln Arg Asp 
465                 470                 475                 480 


Ala Ala Ser Ala Trp Gln Ile Ala Lys Arg Phe Lys Ala Glu Val Ala 
                485                 490                 495     


Ser Thr Ser Gln Pro Ala Glu Ser Gln Asp Ser Ala Asn Ser Ala Ser 
            500                 505                 510         


Val Leu Thr Gln Val 
        515         


<210>  238
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.298446

<400>  238

Met Pro Thr Leu Thr Arg Lys Val Glu Leu Tyr Val Val Gly Asp Lys 
1               5                   10                  15      


Glu Glu Val Ser Arg Val Tyr Asp Tyr Ile Arg Leu Ala Met Asn Ala 
            20                  25                  30          


Thr Tyr Lys Cys Phe Asn Glu Cys Met Thr Ala Leu Tyr Ile Ala Gln 
        35                  40                  45              


Val Lys Glu Asp Thr Lys Glu Asp Arg Lys Glu Leu Asn His Leu Tyr 
    50                  55                  60                  


Ser Arg Gln Thr Tyr Thr Lys Lys Glu Thr Ala Phe Thr Asn Asp Ile 
65                  70                  75                  80  


Val Phe Pro Glu Gly Leu Ala Leu Ala Ala Tyr Val Asn Arg Met Ala 
                85                  90                  95      


Gln Gln Lys Phe Val Thr Ser Leu Lys Asn Gly Leu Met Tyr Gly Cys 
            100                 105                 110         


Val Ser Leu Pro Thr Phe Lys Lys Asp Cys Ala Val Pro Leu His Val 
        115                 120                 125             


Lys Phe Val Ser Leu Ala Gly Glu Lys Gly Thr Asn Thr Gly Phe Tyr 
    130                 135                 140                 


His Glu Tyr Ala Asp Val Asn Asp Leu Val Asn Ala Leu Glu Tyr Asp 
145                 150                 155                 160 


Asn Ser Pro Lys Val Phe Leu Arg Phe Pro Asn Asn Ile Thr Phe Gly 
                165                 170                 175     


Val Val Phe Gly Asn Pro Tyr Arg Gly Arg Glu Gln Arg Ser Val Phe 
            180                 185                 190         


Ser Lys Ile Phe Leu Gly Glu Tyr Lys Ile Gln Gly Ser Ser Ile Gln 
        195                 200                 205             


Ile Asn Ser Arg Gly Lys Ile Ile Leu Asn Leu Ser Met Glu Val Pro 
    210                 215                 220                 


Lys Lys Lys Met Glu His Ile Glu Gly Arg Val Val Gly Val Asp Val 
225                 230                 235                 240 


Gly Leu Ala Ile Pro Ala Met Cys Ala Ile Asn Asp Asp Asp Tyr Thr 
                245                 250                 255     


Arg Ser Ala Ile Gly Asn Ile Asp Asp Phe Leu Lys Val Arg Thr Gln 
            260                 265                 270         


Ile Gln Ser Gln Arg Arg Arg Leu Gln Lys Ser Leu Lys Asn Thr Ser 
        275                 280                 285             


Ser Gly His Gly Arg Thr Lys Lys Leu Lys Pro Leu Glu Arg Ile Ala 
    290                 295                 300                 


Glu Lys Glu Arg Asn Phe Ala Asn Thr Tyr Asn His Met Val Ser Lys 
305                 310                 315                 320 


Arg Val Val Asp Phe Ala Val Lys Asn Gly Ala Ser Gln Ile Asn Ile 
                325                 330                 335     


Glu Asp Leu Ser Gly Phe Ala Lys Asp Lys Asn Gly Lys Ser Val Glu 
            340                 345                 350         


Asp Asp Asn Met Lys Arg Val Leu Ser Asn Trp Ser Tyr Phe Glu Leu 
        355                 360                 365             


Gln Gln Gln Ile Arg Tyr Lys Ala Glu Gln Tyr Asp Ile Lys Val Arg 
    370                 375                 380                 


Thr Val Asn Pro Ala Tyr Thr Ser Gln Thr Cys Ser Tyr Cys Gly Gln 
385                 390                 395                 400 


Ile Gly Lys Arg Glu Thr Gln Ser Lys Phe Val Cys Thr Asn Pro Asp 
                405                 410                 415     


Cys Lys Cys His Lys Met Tyr Lys Lys Asp Trp Phe Asn Ala Asp Phe 
            420                 425                 430         


Asn Ala Ala Arg Asn Ile Ala Leu Ser Thr Asp Tyr Thr Asp Asp Glu 
        435                 440                 445             


Asp Gly Lys Lys Thr Lys Lys Lys Lys Ser Ala Lys Lys Lys Pro Glu 
    450                 455                 460                 


Lys Lys Thr Glu Glu Ala 
465                 470 


<210>  239
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.298612

<400>  239

Met Ser Gly Ala Ser Gly Gln Ile Thr Arg Asp Asn Lys Ala Gln Arg 
1               5                   10                  15      


Ser Gly Pro Asn Lys Gly Glu Met Ser Glu Asp His Ser Ser Thr Lys 
            20                  25                  30          


Arg Pro Lys Arg Val Val Lys Val Ala Lys Tyr Arg Ile Ile Lys Pro 
        35                  40                  45              


Val Gly Glu Met Thr Trp Pro Glu Leu Gly Glu Ile Leu Arg Thr Val 
    50                  55                  60                  


Arg Tyr Arg Val Phe Arg Leu Gly Asn Leu Ala Val Ser Glu Ala Tyr 
65                  70                  75                  80  


Leu Asn Phe His Ala Phe Arg Thr Gly Lys Ala Glu Glu Phe Lys Ser 
                85                  90                  95      


Glu Thr Ile Gly Lys Leu Ser Arg Arg Leu Arg Asp Met Leu Ile Ser 
            100                 105                 110         


Glu Gly Val Lys Lys Glu Asp Ile Asp Arg Tyr Ser Ala Thr Gly Ala 
        115                 120                 125             


Val Pro Asp Thr Val Ala Gly Ala Leu Gly Gln Tyr Lys Val Arg Gly 
    130                 135                 140                 


Ile Thr Ser Pro Ala Lys Trp Arg Gln Val Ile Arg Gly Thr Val Ser 
145                 150                 155                 160 


Leu Pro Thr Phe Arg Asn Asp Met Ala Ile Pro Val Arg Cys Asp Lys 
                165                 170                 175     


Pro Ala Gln Arg Arg Leu Glu Lys Ala Lys Ser Glu Glu Val Glu Val 
            180                 185                 190         


Asp Leu Met Ile Cys Arg Lys Pro Tyr Pro Arg Val Leu Ile Gly Thr 
        195                 200                 205             


Ala Asp Leu Gly Gly Gly Gln Gln Ala Ile Leu Glu Arg Leu Leu Asp 
    210                 215                 220                 


Asn Lys Asp Asn Ser Ser Asp Gly Tyr Arg Gln Arg Leu Phe Glu Ile 
225                 230                 235                 240 


Lys Gln Asp Thr Gln Ser Lys Lys Trp Phe Leu Phe Val Thr Tyr Asp 
                245                 250                 255     


Phe Pro Ser Ser Gly Ala Leu Pro Leu Asp Pro Asn Val Ala Val Gly 
            260                 265                 270         


Val Asp Leu Gly Val Ser Val Pro Leu Tyr Ala Ala Ile Asn Asn Gly 
        275                 280                 285             


His Ala Arg Leu Gly Arg Arg Gln Phe Gln Ala Leu Gly Ser Arg Ile 
    290                 295                 300                 


Arg Ser Leu Gln Thr Gln Val Asp Ala Arg Arg Arg Ala Ile Gln Arg 
305                 310                 315                 320 


Gly Gly Arg Ser Asp Val Ser Gln Ser Thr Ala Arg Ser Gly His Gly 
                325                 330                 335     


Val Arg Arg Lys Leu Gln Pro Thr Glu Lys Leu Arg Lys Arg Ile Asp 
            340                 345                 350         


Arg Ser Tyr Ser Thr Leu Asn His Gln Leu Ser Ala Ala Val Val Glu 
        355                 360                 365             


Phe Ala Lys Asn Gln Gly Ala Gly Thr Val Gln Met Glu Asp Leu Gly 
    370                 375                 380                 


Gly Leu Arg Glu Glu Leu Thr Gly Thr Phe Ile Gly Ala Arg Trp Arg 
385                 390                 395                 400 


Tyr His Gln Leu Gln Gln Phe Leu Glu Tyr Lys Cys Asp Glu Ala Gly 
                405                 410                 415     


Ile Thr Leu Asn Lys Val Asn Pro Met Tyr Thr Ser Arg Arg Cys Ser 
            420                 425                 430         


Glu Cys Gly Phe Ile Asp Lys Asp Phe Asp Arg Ala Phe Arg Asp Arg 
        435                 440                 445             


Ser Arg Ser Asp Gly Arg Val Ala Arg Phe Ile Cys Pro Glu Cys Ser 
    450                 455                 460                 


Tyr Glu Ala Asp Pro Asp Tyr Asn Ala Ala Arg Asn Ile Ala Thr Leu 
465                 470                 475                 480 


Asp Ile Asp Lys Leu Ile Arg Val Gln Cys Gln Lys Gln Gly Leu Lys 
                485                 490                 495     


Tyr Asp Ala Leu 
            500 


<210>  240
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.299584

<400>  240

Met Ile Ile Thr Arg Lys Ile Glu Leu Trp Leu Ser Glu Asp Asp Asn 
1               5                   10                  15      


Glu Leu Arg Lys Ala Lys Trp Ser Tyr Leu Lys Glu Leu Asn Asp Glu 
            20                  25                  30          


Val Tyr Arg Ala Ala Asn Phe Ile Val Asn Asn Gln Tyr Phe Asn Glu 
        35                  40                  45              


Ile Leu Glu Asn Arg Val Ile Met Gln Asp Thr Arg Leu Ile Asp Ile 
    50                  55                  60                  


Asp Ser Glu Ile Arg Lys Leu Tyr Lys Ser Arg Glu Lys Asn Lys Glu 
65                  70                  75                  80  


Lys Ile Asp Glu Leu Lys Lys Ile Lys Lys Ile Arg Tyr Gln Glu Ala 
                85                  90                  95      


Lys Asn Phe Tyr Gln Thr Ser Lys Gln Asn Val Thr Tyr Gln Leu Thr 
            100                 105                 110         


Ser Arg Glu Phe Pro Asn Ile Pro Ala Asn Ile Val Thr Ser Leu Asn 
        115                 120                 125             


Ala Ser Ile Ile Lys Thr Leu Lys Thr Glu Trp Asn Glu Ile Lys Ser 
    130                 135                 140                 


Gly Lys Arg Ala Val Arg Asn Tyr Arg Lys Gly Met Pro Ile Pro Phe 
145                 150                 155                 160 


Asn Phe Ser Ser Ser Gln Lys Trp Phe Glu Asn Lys Gly Glu Asp Ile 
                165                 170                 175     


Phe Leu Asn Trp Leu Gly Gly Leu Lys Phe Lys Leu Phe Phe Gly Arg 
            180                 185                 190         


Asp Lys Ser Asn Asn Arg Ala Ile Val Glu Arg Ala Ile Asn Lys Glu 
        195                 200                 205             


Tyr Lys Tyr Ala Asp Ser Ser Ile Gln Leu Lys Asp Lys Lys Ile Phe 
    210                 215                 220                 


Leu Leu Phe Val Val Asp Ile Pro Tyr Glu Lys Ala Asn Leu Asn Lys 
225                 230                 235                 240 


Asn Ile Ala Ala Gly Val Asp Leu Gly Ile Ala Phe Pro Ala Phe Cys 
                245                 250                 255     


Ala Leu Ser Glu Gly Tyr Ser Arg Leu Ser Ile Gly Asn Lys Glu Asp 
            260                 265                 270         


Leu Leu Lys Val Arg Leu Gln Met Gln Ser Arg Arg Lys Arg Leu Gln 
        275                 280                 285             


Lys Ala Leu Lys Ile Thr Ser Gly Gly Lys Gly Arg Thr Lys Lys Leu 
    290                 295                 300                 


Lys Ala Leu Glu Ser Leu Thr Asn Lys Glu Lys Asn Tyr Val Thr Thr 
305                 310                 315                 320 


Tyr Asn His Lys Val Ser Tyr Gln Val Ile Lys Phe Ala Lys Asp Asn 
                325                 330                 335     


Lys Ala Gly Ile Ile Lys Leu Glu Phe Leu Glu Gly Phe Gly Glu Asp 
            340                 345                 350         


Glu Lys Asn Lys Phe Ile Leu Arg Asn Trp Ser Phe Tyr Gln Leu Gln 
        355                 360                 365             


Lys Met Ile Glu Tyr Lys Ala Lys Arg Glu Gly Ile Glu Val Leu Tyr 
    370                 375                 380                 


Ile Asp Pro Tyr His Thr Ser Gln Thr Cys Ala Ile Cys Gly Asn Tyr 
385                 390                 395                 400 


Glu Glu Gly Gln Arg Glu Lys Gln Glu Asp Phe Ile Cys Lys Asn Pro 
                405                 410                 415     


Glu Cys Lys Asn Phe Glu Lys Ile Val Asn Ala Asp Tyr Asn Ala Ala 
            420                 425                 430         


Leu Asn Ile Ala Lys Ser Asn Lys Ile Val Ser Ser Ser Glu Gln Cys 
        435                 440                 445             


Glu Tyr Asn Lys Lys His Glu Asn Asn Val Leu 
    450                 455                 


<210>  241
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  241

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Arg Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  242
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  242

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Arg Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  243
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant  of CasM.19952

<400>  243

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Arg 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  244
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  244

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Arg Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  245
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  245

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Arg Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  246
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  246

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Arg Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  247
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  247

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Arg Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  248
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  248

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Arg Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  249
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  249

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Arg Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  250
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  250

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Arg Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  251
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  251

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Arg Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  252
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  252

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Arg Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  253
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  253

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Arg Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  254
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  254

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Arg Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  255
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  255

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Arg Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  256
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  256

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Arg Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  257
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  257

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Arg 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  258
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  258

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Arg Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  259
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  259

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Arg Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  260
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variants of CasM.19952

<400>  260

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Arg Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  261
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  261

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Arg Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  262
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  262

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Arg Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  263
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  263

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Arg Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  264
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  264

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Arg Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  265
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  265

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Arg Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  266
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  266

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Arg Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  267
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  267

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Arg Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  268
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  268

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Arg Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  269
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  269

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Arg Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  270
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  270

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Arg Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  271
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  271

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Arg Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  272
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  272

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Arg 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  273
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  273

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Arg Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  274
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  274

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Arg Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  275
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  275

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Arg Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  276
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  276

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Arg Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  277
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  277

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Arg Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  278
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  278

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Arg Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  279
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  279

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Arg Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  280
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  280

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Arg Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  281
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  281

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Arg Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  282
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  282

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Arg Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  283
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  283

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Arg Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  284
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  284

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Arg Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  285
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  285

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Arg Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  286
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  286

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Arg Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  287
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  287

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Arg Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  288
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  288

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Arg Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  289
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  289

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Arg Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  290
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  290

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Arg 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  291
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  291

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Arg Asn Glu 
465             


<210>  292
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  292

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Arg Glu 
465             


<210>  293
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of CasM.19952

<400>  293

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Arg 
465             


<210>  294
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M

<400>  294
gatggatgaa acccagacac                                                   20


<210>  295
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Amplicon Primers

<400>  295
tcgtcggcag cgtcagatgt gtataagaga cagcccaagt gaaataccct ggc              53


<210>  296
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Amplicon Primers

<400>  296
gtctcgtggg ctcggagatg tgtataagag acagcagtgg gggtgaattc agtg             54


<210>  297
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2M4

<400>  297

Gly Gly Cys Cys Gly Ala Gly Ala Thr Gly Thr Cys Thr Cys Gly Cys 
1               5                   10                  15      


Thr Cys Cys Gly 
            20  


<210>  298
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Forward Amplicon Primers

<400>  298

Thr Cys Gly Thr Cys Gly Gly Cys Ala Gly Cys Gly Thr Cys Ala Gly 
1               5                   10                  15      


Ala Thr Gly Thr Gly Thr Ala Thr Ala Ala Gly Ala Gly Ala Cys Ala 
            20                  25                  30          


Gly Cys Cys Thr Cys Thr Cys Thr Cys Thr Ala Ala Cys Cys Thr Gly 
        35                  40                  45              


Gly Cys Ala Cys Thr 
    50              


<210>  299
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Reverse Amplicon Primers

<400>  299

Gly Thr Cys Thr Cys Gly Thr Gly Gly Gly Cys Thr Cys Gly Gly Ala 
1               5                   10                  15      


Gly Ala Thr Gly Thr Gly Thr Ala Thr Ala Ala Gly Ala Gly Ala Cys 
            20                  25                  30          


Ala Gly Gly Ala Gly Gly Gly Thr Ala Gly Gly Ala Gly Ala Gly Ala 
        35                  40                  45              


Cys Thr Cys Ala Cys 
    50              


<210>  300
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VPR

<400>  300

Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
1               5                   10                  15      


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            20                  25                  30          


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        35                  40                  45              


Met Leu Ile Asn Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys 
    50                  55                  60                  


Val Gly Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu 
65                  70                  75                  80  


Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys 
                85                  90                  95      


Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile 
            100                 105                 110         


Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln 
        115                 120                 125             


Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe 
    130                 135                 140                 


Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu 
145                 150                 155                 160 


Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro 
                165                 170                 175     


Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro 
            180                 185                 190         


Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys 
        195                 200                 205             


Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu 
    210                 215                 220                 


Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp 
225                 230                 235                 240 


Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln 
                245                 250                 255     


Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro 
            260                 265                 270         


Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala 
        275                 280                 285             


Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu 
    290                 295                 300                 


Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp 
305                 310                 315                 320 


Met Asp Phe Ser Ala Leu Leu Gly Ser Gly Ser Gly Ser Arg Asp Ser 
                325                 330                 335     


Arg Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser 
            340                 345                 350         


Asp Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile Arg Pro 
        355                 360                 365             


Phe His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser 
    370                 375                 380                 


Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val Gly Ser Leu 
385                 390                 395                 400 


Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala Val Thr 
                405                 410                 415     


Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln 
            420                 425                 430         


Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro Gln Lys 
        435                 440                 445             


Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro Pro Pro 
    450                 455                 460                 


Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met Thr Glu 
465                 470                 475                 480 


Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu 
                485                 490                 495     


Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met His Ile Ser 
            500                 505                 510         


Thr Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe 
        515                 520             


<210>  301

<400>  301
000

<210>  302

<400>  302
000

<210>  303

<400>  303
000

<210>  304

<400>  304
000

<210>  305

<400>  305
000

<210>  306

<400>  306
000

<210>  307

<400>  307
000

<210>  308

<400>  308
000

<210>  309

<400>  309
000

<210>  310

<400>  310
000

<210>  311

<400>  311
000

<210>  312

<400>  312
000

<210>  313

<400>  313
000

<210>  314

<400>  314
000

<210>  315

<400>  315
000

<210>  316

<400>  316
000

<210>  317

<400>  317
000

<210>  318

<400>  318
000

<210>  319

<400>  319
000

<210>  320

<400>  320
000

<210>  321

<400>  321
000

<210>  322

<400>  322
000

<210>  323

<400>  323
000

<210>  324

<400>  324
000

<210>  325

<400>  325
000

<210>  326

<400>  326
000

<210>  327

<400>  327
000

<210>  328

<400>  328
000

<210>  329

<400>  329
000

<210>  330

<400>  330
000

<210>  331

<400>  331
000

<210>  332

<400>  332
000

<210>  333

<400>  333
000

<210>  334

<400>  334
000

<210>  335

<400>  335
000

<210>  336

<400>  336
000

<210>  337

<400>  337
000

<210>  338

<400>  338
000

<210>  339

<400>  339
000

<210>  340

<400>  340
000

<210>  341

<400>  341
000

<210>  342

<400>  342
000

<210>  343

<400>  343
000

<210>  344

<400>  344
000

<210>  345

<400>  345
000

<210>  346

<400>  346
000

<210>  347

<400>  347
000

<210>  348

<400>  348
000

<210>  349

<400>  349
000

<210>  350

<400>  350
000

<210>  351

<400>  351
000

<210>  352

<400>  352
000

<210>  353

<400>  353
000

<210>  354

<400>  354
000

<210>  355

<400>  355
000

<210>  356

<400>  356
000

<210>  357

<400>  357
000

<210>  358

<400>  358
000

<210>  359

<400>  359
000

<210>  360

<400>  360
000

<210>  361

<400>  361
000

<210>  362

<400>  362
000

<210>  363

<400>  363
000

<210>  364

<400>  364
000

<210>  365

<400>  365
000

<210>  366

<400>  366
000

<210>  367

<400>  367
000

<210>  368

<400>  368
000

<210>  369

<400>  369
000

<210>  370

<400>  370
000

<210>  371

<400>  371
000

<210>  372
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  372
agggcgacuu cccguccuga aaucgagaaa gugacaagga aagcgcaauu uugcgccguu       60

guaauacacu cgagaagguc aagguguaca uaguaauccg uacacgac                   108


<210>  373
<211>  149
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  373
agggcgacuu cccguccuga aaucgagaaa gugacaagga aagcgcaauu uugcgccguu       60

guaauacacu cgagaagguc aagguguaca uaguaauccg uacacgacga aagcugggug      120

aguugaaggu auuaaauacu cguauugcu                                        149


<210>  374
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  374
agggcgacuc ggcguccuaa aaucgagaaa guguacauaa guauuuaaca aaauacggua       60

aauacucucg guaagguuuu aacgugcaca uaauaauccg ugcaacaggg uuacacuuuu      120

guugaaaguu gcaacuuacg cauaggugua aaauacgagg uauuaaauac ucguauugcu      180


<210>  375
<211>  181
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  375
ggggcggcuc ggcgucccaa aaucgagaaa guauauguaa aucugaauuu auucaguagu       60

agauacacuc gauaagguau aaacaauaca cauuuuaauc cguguauuga acuuauuuag      120

cuauugaaag uugcaauucg uaugcgcagg uaaguuucga guauuaaaua cucguauugc      180

u                                                                      181


<210>  376
<211>  174
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  376
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc cacaaugaaa auccugugga caccguauaa      120

uaugugcaug uuugaaaugu gcaugaggug ugaguauuaa auacucguau ugcu            174


<210>  377
<211>  118
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  377
uucuuuccuc ggaaaguggu agauacucuc gguaagguaa acuguguaug aacaguuuga       60

aauccugcac auaaaaugaa acaggcguaa gaugugagua uuaaauacuc guauugcu        118


<210>  378
<211>  125
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  378
ucgggcggcu cggcguccgu aaaccgagaa aguauaugua agucugaauu uauucagcgu       60

uagauacacu cgguaagguu caaagaaaua uggguaugcu gcgaguauua aauacucgua      120

uugcu                                                                  125


<210>  379
<211>  167
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  379
ucgggcggcu cggcguccgu aaaccgagaa aguauaugua agucugaauu uauucagcgu       60

uagauacacu cgguaagguu caaacaauac auauucaauc cauguauuca guauauuugu      120

acauuugaaa uauggguaug cugcgaguau uaaauacucg uauugcu                    167


<210>  380
<211>  143
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  380
uagaagguuc acacaauuuc agggcgacuc ggcguccuaa aaucgagaaa guguacauaa       60

auuuuuaaca aaauacggua aauacucucg guaagguuuu aagaaauagg uguaaaauac      120

gaguauuaaa uacucguauu gcu                                              143


<210>  381
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  381
cagggcgacu cggcguccua aaaucgagaa aguguacaua aauuuuuaac aaaauacggu       60

aaauacucuc gguaagguuu uaacgugcac auaauaaucc gugcaacagg guuacacuuu      120

ugugcaauuu ugaaauaggu guaaaauacg aguauuaaau acucguauug cu              172


<210>  382
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  382
auaaguugcc gccgauaaau auugcgauag cccacgggca auugcgcaac cggcggcgau       60

aggccgacuc gaacggccug aaaguugaga aggcacaugu uggaggaaau uuuuuuccca      120

uuguguuuuc gcucacuaau acacgcaacu ugaaaugcgg uguaauucga gguauuaaau      180

acucguauug cu                                                          192


<210>  383
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  383
ggugugaacg accuuuuuuu gcgguguaau ucgagguauu aaauacucgu auugcu           56


<210>  384
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  384
uaggccgacu cgaacggccu gaaaguugag aaggcacaug uuggaggaaa uuuuuuuccc       60

auuguguuuu cgcucacuaa uacacgcaac uu                                     92


<210>  385
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  385
uaggccgacu cgaacggccu gaaaguugag aaggcacaug uuggaggaaa uuuuuuuccc       60

auuguguuuu cgcucacuaa uacacgcaac uugaaaugcg guguaauucg agguauuaaa      120

uacucguauu gcu                                                         133


<210>  386
<211>  136
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  386
uaggccgacu cgaacggccu gaaaguugag aaggcacaua uuagaggaaa uuuguuuccc       60

auuguguuuu cgcucacuaa uacacgcaag uuuugaaauu gcgguguacu ucgagguauu      120

aaauacucgu auugcu                                                      136


<210>  387
<211>  190
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  387
uugccggcgg caaaaauugc gauagccucc gggcaauugc gcaaucgccg gcgauaggcc       60

gacucgaacg gccugaaagu ugagaaggca cauauuagag gaaauuuguu ucccauugug      120

uuuucgcuca cuaauacacg caaguuuuga aauugcggug uacuucgagg uauuaaauac      180

ucguauugcu                                                             190


<210>  388
<211>  126
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  388
ggggcgacuu cccgucccaa aaucgagaaa guggucguaa gucucgaucg gaucgaagca       60

gacaauacac ucgaaaaggu uaagugaaaa gcguguggcu ugaagguauu aaauacucgu      120

auugcu                                                                 126


<210>  389
<211>  126
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  389
ggggcgacuu cccgucccaa aaucgagaaa guggucguaa gucucgaucg gaucgaagca       60

gacaauacac ucgaaaaggu uaagugaaaa gcguguggcu ugaagguauu aaauacucgu      120

auugcu                                                                 126


<210>  390
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  390
ggggcgacuu cccgucccua aaucgagaaa guggcgguaa gacuucgguc uucgaagcgc       60

gcaauacacu cgaaaagguu aagaaaugaa ugcgacuuga agguauuaaa uacucguauu      120

gcu                                                                    123


<210>  391
<211>  149
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  391
ggggcgacuu cccgucccua aaucgagaaa guggcgguaa gacuucgguc uucgaagcgc       60

gcaauacacu cgaaaagguu aagaugcaca uaguaauccg ugcaugggga aaugaaugcg      120

acuugaaggu auuaaauacu cguauugcu                                        149


<210>  392
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  392
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccgaaaau       60

ccaacuauua aauacucgua uugcu                                             85


<210>  393
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  393
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaaaggu acauccaacu auuaaauacu cguauugcu                              99


<210>  394
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  394
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaaggaa agguacaucc aacuauuaaa uacucguauu gcu                        103


<210>  395
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  395
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaaaaaa ggaaagguac auccaacuau uaaauacucg uauugcu                    107


<210>  396
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  396
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaaaugg caaaaggaaa gguacaucca acuauuaaau acucguauug cu              112


<210>  397
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  397
augaauagga uuuauccuau ggggcaguug guugcccuua gccugaggca uuuaaugcac       60

ucgggaagua ccuuuucuca gaaaagguac auccaacuau uaaauacucg uauugcu         117


<210>  398
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  398
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cauucgaggu acauccaacu auuaaauacu cguauugcu                              99


<210>  399
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  399
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaga aaagguacau       60

ccaacuauua aauacucgua uugcugu                                           87


<210>  400
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  400
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaga aaagguacau       60

ccaacuauua aauacucgua uugcugu                                           87


<210>  401
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  401
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaga aaagguacau       60

ccaacuauua aauacucgua uugcuguucg au                                     92


<210>  402
<211>  95
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  402
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaga aaagguacau       60

ccaacuauua aauacucgua uugcuguucg auuau                                  95


<210>  403
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  403
agggcgacuu cccguccuaa aaucgagaua gugacaaguc agucucuuau gaggagcauu       60

guaauacacu cgagaagguc aagguguaca uaguaauccg uacacgacg                  109


<210>  404

<400>  404
000

<210>  405
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  405
cguugcagcu cgcacguugg cacuggguug aagguauuaa auacucguau ugcu             54


<210>  406
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  406
ggggcgucuu cccgucccua aaucgagaua gcagccauuu uucuucauuu uugaagacgg       60

ucuugcacuc gaaaagguca aggaaauugg cacugguuga agguauuaaa uacucguauu      120

gcu                                                                    123


<210>  407
<211>  119
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  407
ggggcgucuu cccgucccua aaucgagaua gcagccauuu uucuucauuu uugaagacgg       60

ucuugcacuc gaaaagguca aggaaacacu gguugaaggu auuaaauacu cguauugcu       119


<210>  408
<211>  175
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  408
auauuaaggg cggcucagcg uccuuaaguc gagaaaguau acauaaauuu cuuauauaga       60

auaguagaua cucucggcaa gguauaaacc cuacaaauuu aauccuugua ggcaacuuau      120

auuuguauuu auuugaaaca uauguagguu gugaguauua aauacucgua uugcu           175


<210>  409
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  409
auauuaaggg cggcucagcg uccuuaaguc gagaaaguau acauaaauuu cuuauauaga       60

auaguagaua cucucggcaa gguauaaacc cuacaaauuu aauccuugua ggcaacuuau      120

auuuguauuu auuugaaaug uagguuguga guauuaaaua cucguauugc u               171


<210>  410
<211>  170
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  410
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc cacaaugaaa auccugugga caccguauaa      120

uaugugcaug uuugaaacau gaggugugag uauuaaauac ucguauugcu                 170


<210>  411
<211>  131
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  411
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc gaaaugugca ugagguguga guauuaaaua      120

cucguauugc u                                                           131


<210>  412
<211>  127
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  412
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc gaaacaugag gugugaguau uaaauacucg      120

uauugcu                                                                127


<210>  413
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  413
gaugugaacg accuuuuuuu gcggugugcu ucgagguauu aaauacucgu auugcu           56


<210>  414
<211>  151
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  414
uaugcugccg ccgauaaagg uugcgauagc uuucgggcaa uugcgcaacc ggcggcgaua       60

ggccgacucg aacggccuga aaguugagaa ggcacauauu agaggaaaau uguuucccau      120

uguguuuucg cucacuaaca cacgcaaauu u                                     151


<210>  415
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  415
aaugugaacg accuucuuuu gcgguguacu ucgagguauu aaauacucgu auugcu           56


<210>  416
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  416
auguugccgc cgauaaaggu uacgauagcc ugcgggcaau ugcguaaccg gcggcgauag       60

gccgacucga acggccugaa gguugagaag gcacaauaag uggaaaauuu guuucuuccc      120

auuguguucg cucaccaaua cacgcaauuu                                       150


<210>  417
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  417
auuguaggcg accuuuuuuu gcgauguagu ucgagguauu aaauacucgu auugcu           56


<210>  418
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  418
aaggccggcu cgaacggccu gaagguugag uuuaaaguca cauauaagcg gaaaaaucag       60

auuucccauu guguucgcuc accaauacgc gcaaauuu                               98


<210>  419
<211>  149
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  419
aacugccggu aagauuacga uagccgaaag gcaauugcgu augcggcagu uaaggccggc       60

ucgaacggcc ugaagguuga guuuaaaguc acauauaagc ggaaaaauca gauuucccau      120

uguguucgcu caccaauacg cgcaaauuu                                        149


<210>  420
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  420
guugcguuug cccgugauuu cgggugugua uacagguauu aaauacucgu auugcu           56


<210>  421
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  421
ggccacccug uuuggccuua aggugagaag ugugcgagua aguggugaaa aaucgcccgu       60

ugcccacgcu caccgaauga cccgcacg                                          88


<210>  422
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  422
gguggauauc aucuuaaaaa gugagguaca uccaacuauu aaauacucgu auugcu           56


<210>  423
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  423
gaauaauaau uucgauauga augaaaauag uugaauaaaa auauucaaau gggguuguug       60

gaaacccuua ugcugagggc uuaugccacu cgguaaguac cuuaa                      105


<210>  424
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  424
gggguuguug gaaacccuua ugcugagggc uuaugccacu cgguaaguac cuuaaa           56


<210>  425
<211>  165
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  425
gaauaauaau uucgauauga augaaaauag uugaauaaaa auauucaaau gggguuguug       60

gaaacccuua ugcugagggc uuaugccacu cgguaaguac cuuaagaaag guggauauca      120

ucuuaaaaag ugagguacau ccaacuauua aauacucgua uugcu                      165


<210>  426
<211>  116
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  426
gggguuguug gaaacccuua ugcugagggc uuaugccacu cgguaaguac cuuaaagaaa       60

gguggauauc aucuuaaaaa gugagguaca uccaacuauu aaauacucgu auugcu          116


<210>  427
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  427
ggcguauguc uaccugaaaa agaagguaua uccaacuauu aaauacucgu auugcu           56


<210>  428
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  428
aaguuuugaa uaacaauaau auucaaauug gggcuguugg gggcccuuau gcugagggau       60

uauuccacuc ggcaaguacc uauauuaaug gaggccag                               98


<210>  429
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  429
ggggcuguug ggggcccuua ugcugaggga uuauuccacu cggcaaguac cuauauuaau       60

ggaggccag                                                               69


<210>  430
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  430
gauguaaauc aucuauaaaa gaaagguaca uccaacuauu aaauacucgu auugcu           56


<210>  431
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  431
cuuuggauuu aaauauucaa cgggguuguu ggaaacccuu augcugaggg auuauuccac       60

ucgguaagua ccuuaaauag uuaua                                             85


<210>  432
<211>  64
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  432
gggguuguug gaaacccuua ugcugaggga uuauuccacu cgguaaguac cuuaaauagu       60

uaua                                                                    64


<210>  433
<211>  145
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  433
cuuuggauuu aaauauucaa cgggguuguu ggaaacccuu augcugaggg auuauuccac       60

ucgguaagua ccuuaaauag uuauagaaag auguaaauca ucuauaaaag aaagguacau      120

ccaacuauua aauacucgua uugcu                                            145


<210>  434
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  434
gggguuguug gaaacccuua ugcugaggga uuauuccacu cgguaaguac cuuaaauagu       60

uauagaaaga uguaaaucau cuauaaaaga aagguacauc caacuauuaa auacucguau      120

ugcu                                                                   124


<210>  435
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  435
aguguaugau uaccuguagu augagguaca uccaacuauu aaauacucgu auugcu           56


<210>  436
<211>  95
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  436
aaguuuugaa uaacaauauu auucaaauug gggcaguugg augcccuuau gcugagggau       60

uauuccacuc ggcaaguacc aauaauaaug gaugu                                  95


<210>  437
<211>  66
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  437
ggggcaguug gaugcccuua ugcugaggga uuauuccacu cggcaaguac caauaauaau       60

ggaugu                                                                  66


<210>  438
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  438
gauaguuuua acuuccauuu gaaauguaaa ugcaacuauu aaauacucgu auugcu           56


<210>  439
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  439
ugaaauauga aauaaauuuu auguaucauu uuuaaaaaac gggugguugc acauccgaag       60

ggugaggauu uuuucacuca cuaauacuac aaauggaaaa auuua                      105


<210>  440
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  440
cgggugguug cacauccgaa gggugaggau uuuuucacuc acuaauacua caaauggaaa       60

aauuuaaag                                                               69


<210>  441
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  441
auaggauucg uccuaugggg caguugguug cccuuagccu gaggcauuua uugcacucgg       60

gaaguuccuu aaucuaaugg cuuucagaaa agguacaucc aacuauuaaa uacucguauu      120

gcu                                                                    123


<210>  442
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  442
ggggcaguug guugcccuua gccugaggca uuuauugcac ucgggaaguu ccuuaaucua       60

auggcuuuca gaaaagguac auccaacuau uaaauacucg uauugcu                    107


<210>  443
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  443
auaggauuua uccuauaggg caguugguug cccuuagccu gaggcauuua augcacucgg       60

gaaguaccau auuucuuuag cuaucagaaa agguacaucc aacuauuaaa uacucguauu      120

gcu                                                                    123


<210>  444
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  444
agggcaguug guugcccuua gccugaggca uuuaaugcac ucgggaagua ccauauuucu       60

uuagcuauca gaaaagguac auccaacuau uaaauacucg uauugcu                    107


<210>  445
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  445
agggcaguug guugcccuua gccugaggca uuuaaugcac ucgggaagua ccauauuucu       60

uuagcuauca gaaaagguac auccaacuau uaaauacucg uauugcu                    107


<210>  446
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  446
ggggcaguug guugcccuua gccugaggca uuuauugcac ucgggaagua ccauuucuug       60

uugaagaaau gguacaucca acuauuaaau acucguauug cu                         102


<210>  447
<211>  131
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  447
aagauaugaa uaggaguauu ccuauggggc aguugguugc ccuuagccug agguauuuaa       60

ugcacucggg aaguacuuuc aacaguaucc guuagaaaag guacauccaa cuauuaaaua      120

cucguauugc u                                                           131


<210>  448
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  448
ggggcaguug guugcccuua gccugaggua uuuaaugcac ucgggaagua cuuucaacag       60

uauccguuag aaaagguaca uccaacuauu aaauacucgu auugcu                     106


<210>  449
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  449
aauaggauuu auccuauggg gcaguuggau gcccuuagcc ugaggcauuu uuauugcacu       60

cgggaaguac uuucuaaaua acuaucagaa agagcacauc caacuauuaa auacucguau      120

ugcu                                                                   124


<210>  450
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  450
ggggcaguug gaugcccuua gccugaggca uuuuuauugc acucgggaag uacuuucuaa       60

auaacuauca gaaagagcac auccaacuau uaaauacucg uauugcu                    107


<210>  451
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  451
auaggauuua uccuaugggg caguugguug cccuuagccu gaggcauuua augcacucgg       60

gaaguaccuu uucucauuga guggcagaaa ggguacaucc aacuauuaaa uacucguauu      120

gcu                                                                    123


<210>  452
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  452
ggggcaguug guugcccuua gccugaggca uuuaaugcac ucgggaagua ccuuuucuca       60

uugaguggca gaaaggguac auccaacuau uaaauacucg uauugcu                    107


<210>  453
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  453
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uuuuucauug agcaacagaa aagguauauc caacuauuaa auacucguau      120

ugcu                                                                   124


<210>  454
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  454
ggggcaguug guugcccuua gccugaggca uuuauugcac ucgggaagua ccuuuuuuca       60

uugagcaaca gaaaagguau auccaacuau uaaauacucg uauugcu                    107


<210>  455
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  455
aauaggaauu auccuauggg gcaguugguu guccuuagcc ugagguauuu auugcacucg       60

ggaaguacuu uuuacauuaa cuaucagaaa ggguacaucc aacuauuaaa uacucguauu      120

gcu                                                                    123


<210>  456
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  456
ggggcaguug guuguccuua gccugaggua uuuauugcac ucgggaagua cuuuuuacau       60

uaacuaucag aaaggguaca uccaacuauu aaauacucgu auugcu                     106


<210>  457
<211>  134
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  457
gaauaaugaa gaauaggauu cguccuaugg ggcaguuggu ugcccuuagc cugaggaauu       60

uaauucacuc gggaaguacu uuucuuauug ugugacagaa aggguacauc caacuauuaa      120

auacucguau ugcu                                                        134


<210>  458
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  458
ggggcaguug guugcccuua gccugaggaa uuuaauucac ucgggaagua cuuuucuuau       60

ugugugacag aaaggguaca uccaacuauu aaauacucgu auugcu                     106


<210>  459
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  459
guugcaacuu acgcauaggu guaaaauacg agguauuaaa uacucguauu gcu              53


<210>  460
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  460
agggcgacuc ggcguccuaa aaucgagaaa guguacauaa guauuuaaca aaauacggua       60

aauacucucg guaagguuuu aacgugcaca uaauaauccg ugcaacaggg uuacacuuuu      120

guu                                                                    123


<210>  461
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  461
guugcaauuc guaugcgcag guaaguuucg aguauuaaau acucguauug cu               52


<210>  462
<211>  125
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  462
ggggcggcuc ggcgucccaa aaucgagaaa guauauguaa aucugaauuu auucaguagu       60

agauacacuc gauaagguau aaacaauaca cauuuuaauc cguguauuga acuuauuuag      120

cuauu                                                                  125


<210>  463
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  463
cgggcgggcu guaccgccuu augcugagac uuuuucguac ucggcaaguc accuaauguu       60

gaaaggcuac auacagcuau uaaauacucg uauugcu                                97


<210>  464
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  464
gguguaugug caccauauau guaggugaca uacagcuauu aaauacucgu auugcu           56


<210>  465
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  465
uucggguggg cuguaccacc uuaagcggag ggaauuuucc acuccgcaag uuaccuaua        59


<210>  466
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  466
agggguagcu guuuacccug aaugugaggg gcuauugccc acucauaaac uaccuuuuga       60

aaaagguuga uacagcuauu aaauacucgu auugcu                                 96


<210>  467
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  467
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacaa gucaagccua accagggc                               98


<210>  468
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  468
gggguuguug gaaacccuua ugcugaggga uuauuccacu cgguaaguac cuuaaauagu       60

uauagaaaga uguaaaucau cuauaaaaga aagguacauc caacgccugg aggcuaucca      120

gcgu                                                                   124


<210>  469
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  469
augaauagga uucguccuau ggggcaguug guugcccuua gccugaggca uuuauugcac       60

ucgggaagua ccauuucuca gaaaugguac auccaaccgc uacucucucu uucuggc         117


<210>  470
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  470
augaauagga uucguccuau ggggcaguug guugcccuua gccugaggca uuuauugcac       60

ucgggaagua ccauuucuca gaaaugguac auccaacauc ucaucagggu acuccug         117


<210>  471
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  471
augaauagga uucguccuau ggggcaguug guugcccuua gccugaggca uuuauugcac       60

ucgggaagua ccauuucuca gaaaugguac auccaacgau ggaugaaacc cagacac         117


<210>  472
<211>  117
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  472
augaauagga uucguccuau ggggcaguug guugcccuua gccugaggca uuuauugcac       60

ucgggaagua ccauuucuca gaaaugguac auccaacacc agcuugacau cacagga         117


<210>  473
<211>  170
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  473
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc cacaaugaaa auccugugga caccguauaa      120

uaugugcaug uuugaaacau gaggugugag agugggggug aauucagugu                 170


<210>  474
<211>  170
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  474
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc cacaaugaaa auccugugga caccguauaa      120

uaugugcaug uuugaaacau gaggugugag auagaucgag acauguaagc                 170


<210>  475
<211>  170
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  475
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc cacaaugaaa auccugugga caccguauaa      120

uaugugcaug uuugaaacau gaggugugag auccauccga cauugaaguu                 170


<210>  476
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  476
auggggcagu ugguugcccu uagccugagg aauuuaauuc acucgggaag uaccuuucuc       60

augaaauggu acauccaacg gggaggguuu cucuuccgc                              99


<210>  477
<211>  174
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  477
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc cacaaugaaa auccugugga caccguauaa      120

uaugugcaug uuugaaaugu gcaugaggug ugaguggccu ggaggcuauc cagc            174


<210>  478
<211>  174
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  478
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc cacaaugaaa auccugugga caccguauaa      120

uaugugcaug uuugaaaugu gcaugaggug ugagaguggg ggugaauuca gugu            174


<210>  479
<211>  174
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  479
aaacaagggc ggcucaacgu ccuagaaucg agaaaguaug cguaagacuu auuuauugag       60

cgguagauac ucucgguaag guauaaauuc cacaaugaaa auccugugga caccguauaa      120

uaugugcaug uuugaaaugu gcaugaggug ugagaguggg ggugaauuca gugu            174


<210>  480
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  480
auggggcagu ugguugcccu uagccugagg aauuuaauuc acucgggaag uaccuuucuc       60

augaaauggu acauccaaca cugcucggac cugcauuuu                              99


<210>  481
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  481
auggggcagu ugguugcccu uagccugagg aauuuaauuc acucgggaag uaccuuucuc       60

augaaauggu acauccaacc ugcuuuuacu auuaguggu                              99


<210>  482
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  482
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc ugggcgcccg cuaaguuc                               98


<210>  483
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  483
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuu caggcgcccg cuaaguuc                               98


<210>  484
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  484
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgccua cuaaguuc                               98


<210>  485
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  485
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaauuc                               98


<210>  486
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  486
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcauccg cuaaguuc                               98


<210>  487
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  487
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaaccc uaggcgcccg cuaaguuc                               98


<210>  488
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  488
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uagaugcccg cuaaguuc                               98


<210>  489
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  489
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaaccu uaggcgcccg cuaaguuc                               98


<210>  490
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  490
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuagauuc                               98


<210>  491
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  491
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuggguuc                               98


<210>  492
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  492
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgccug cuaaguuc                               98


<210>  493
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  493
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaaacgcccg cuaaguuc                               98


<210>  494
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  494
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgccca uuaaguuc                               98


<210>  495
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  495
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg ccaaguuc                               98


<210>  496
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  496
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc cgggcgcccg cuaaguuc                               98


<210>  497
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  497
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuu uaggcgcccg cuaaguuc                               98


<210>  498
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  498
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg ccgaguuc                               98


<210>  499
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  499
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcuug cuaaguuc                               98


<210>  500
<211>  196
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  500
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc caggcgcccg cuaaguucug gggcaguugg uugcccuuag      120

ccugaggcau uuauugcacu cgggaaguac cauuucucag aaaugguaca uccaacucca      180

ggcgcccgcu aaguuc                                                      196


<210>  501
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  501
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuagguuc                               98


<210>  502
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  502
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc ugagcgcccg cuaaguuc                               98


<210>  503
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  503
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaagcgcccg cuaaguuc                               98


<210>  504
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  504
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uagacgcccg cuaaguuc                               98


<210>  505
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  505
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaagccc                               98


<210>  506
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  506
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg uuaaguuc                               98


<210>  507
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  507
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcacccg cuaaguuc                               98


<210>  508
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  508
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaagcuc                               98


<210>  509
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  509
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg ucaaguuc                               98


<210>  510
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  510
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgccca cuaaguuc                               98


<210>  511
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  511
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggugcccg cuaaguuc                               98


<210>  512
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  512
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcucg cuaaguuc                               98


<210>  513
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  513
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uagguacccg cuaaguuc                               98


<210>  514
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  514
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cugaguuc                               98


<210>  515
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  515
uggggcaguu ggaugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguuc                               98


<210>  516
<211>  95
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  516
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaag                                  95


<210>  517
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  517
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuacau       60

ccaacucuag gcgcccgcua aguuc                                             85


<210>  518
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  518
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguucgc auguccua                   108


<210>  519
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  519
aauaggauuc guccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguacca uugaaaaaug guacauccaa cucuaggcgc ccgcuaaguu c               111


<210>  520
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  520
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguucgc auguc                      105


<210>  521
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  521
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcguccg cuaaguuc                               98


<210>  522
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  522
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaagucc                               98


<210>  523
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  523
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaagucu                               98


<210>  524
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  524
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguucgc auguccu                    107


<210>  525
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  525
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu gccauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguuc                               98


<210>  526
<211>  114
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  526
aauaggauuc guccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguacca uuucucagaa augguacauc caacucuagg cgcccgcuaa guuc            114


<210>  527
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  527
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguucgc augucc                     106


<210>  528
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  528
uggggcaguu gguugcccuu agccugaggc auuuaaugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguuc                               98


<210>  529
<211>  104
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  529
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguucgc augu                       104


<210>  530
<211>  113
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  530
aauaggauuc guccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguacca uuugaaaaaa ugguacaucc aacucuaggc gcccgcuaag uuc             113


<210>  531
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  531
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguucgc a                          101


<210>  532
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  532
aauaggauuc guccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguacca gaaaugguac auccaacucu aggcgcccgc uaaguuc                    107


<210>  533
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  533
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguuu                               98


<210>  534
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  534
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguucgc                            100


<210>  535
<211>  95
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  535
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauugaaa       60

aaugguacau ccaacucuag gcgcccgcua aguuc                                  95


<210>  536
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  536
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuugaa       60

aaaaugguac auccaacucu aggcgcccgc uaaguuc                                97


<210>  537
<211>  115
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  537
aauaggauuc guccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguacca uuucgaaaga aaugguacau ccaacucuag gcgcccgcua aguuc           115


<210>  538
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  538
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accagaaaug       60

guacauccaa cucuaggcgc ccgcuaaguu c                                      91


<210>  539
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  539
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguucg                              99


<210>  540
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  540
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu acuauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguuc                               98


<210>  541
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  541
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguucgc aug                        103


<210>  542
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  542
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucga       60

aagaaauggu acauccaacu cuaggcgccc gcuaaguuc                              99


<210>  543
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  543
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua uauccaacuc uaggcgcccg cuaaguuc                               98


<210>  544
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  544
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguucgc au                         102


<210>  545
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  545
aauaggauuc guccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguacca ugaaaauggu acauccaacu cuaggcgccc gcuaaguuc                  109


<210>  546
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  546
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguu                                97


<210>  547
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  547
uggggcaguu gguugcccuu agccugagga auuuauuuca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaaguuc                               98


<210>  548
<211>  93
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  548
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accaugaaaa       60

ugguacaucc aacucuaggc gcccgcuaag uuc                                    93


<210>  549
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  549
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc uaggcgcccg cuaagu                                 96


<210>  550
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  550
guugcagaac ccgaauagac gaaugaagga augcaacuga acgcguggag gggcgcu          57


<210>  551
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  551
guugcagaac ccgaauagac gaaugaagga augcaacuuc ccaucacaug ucacuuu          57


<210>  552
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  552
guugcagaac ccgaauagac gaaugaagga augcaaccua uuaguggucg uuuuuuu          57


<210>  553
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  553
guugcagaac ccgaauagac gaaugaagga augcaacucg gggggcgggg gggagaa          57


<210>  554
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  554
guugcagaac ccgaauagac gaaugaagga augcaaccag acuggcccca gagaugc          57


<210>  555
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  555
guugcagaac ccgaauagac gaaugaagga augcaacuuc uguugauuug ucggggg          57


<210>  556
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  556
gcugucagua guaguaaaaa uggggguaca uccaacacau cuuucugugu gccaag           56


<210>  557
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  557
gcugucagua guaguaaaaa uggggguaca uccaaccagc caaaaggcau gcgcuc           56


<210>  558
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  558
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacau aagcgucaga gcgccgag                               98


<210>  559
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  559
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacuc ccaaaggcgc ggcgcuga                               98


<210>  560
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  560
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaacag aaaacggaaa cccagaag                               98


<210>  561
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  561
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaaccu uugcagacug gccccaga                               98


<210>  562
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  562
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaaca uaagcgucag agcgccgag                              99


<210>  563
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  563
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacc ggggccucug gcuccccca                              99


<210>  564
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  564
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacu cccaaaggcg cggcgcuga                              99


<210>  565
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  565
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacc auguccuagc accucuggg                              99


<210>  566
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  566
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacc gugcuguuuc cuccccacg                              99


<210>  567
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  567
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacg ggggcggggg ggagaaaaa                              99


<210>  568
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  568
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaaca gaaaacggaa acccagaag                              99


<210>  569
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  569
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacc uuugcagacu ggccccaga                              99


<210>  570
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  570
auggggcagu ugguugcccu uagccugagg aauuuaauuc acucgggaag uaccuuucuc       60

augaaauggu acauccaaca cuggcugggg caccauuag                              99


<210>  571
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  571
auggggcagu ugguugcccu uagccugagg aauuuaauuc acucgggaag uaccuuucuc       60

augaaauggu acauccaaca agucaagccu aaccagggc                              99


<210>  572
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  572
auggggcagu ugguugcccu uagccugagg aauuuaauuc acucgggaag uaccuuucuc       60

augaaauggu acauccaacg uggucguuuu uuucucccc                              99


<210>  573
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  573
auggggcagu ugguugcccu uagccugagg aauuuaauuc acucgggaag uaccuuucuc       60

augaaauggu acauccaaca uuugucgggg ggcgggggg                              99


<210>  574
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  574
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaaca cuggcugggg caccauuag                              99


<210>  575
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  575
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacc ugcuuuuacu auuaguggu                              99


<210>  576
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  576
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacu cuuccgccau agauaacua                              99


<210>  577
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  577
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacg uggucguuuu uuucucccc                              99


<210>  578
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  578
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacg uggucguuuu uuucucccc                              99


<210>  579
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  579
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaaca uuugucgggg ggcgggggg                              99


<210>  580
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  580
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacg uuggccaggc uggucuuga                              99


<210>  581
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  581
auggggcagu uggaugcccu uagccugagg cauuuauugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacc ggggccucug gcuccccca                              99


<210>  582
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  582
auggggcagu uggaugcccu uagccugagg cauuuauugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacu cccaaaggcg cggcgcuga                              99


<210>  583
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  583
auggggcagu uggaugcccu uagccugagg cauuuauugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacc ccggguaagc cugucugcu                              99


<210>  584
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  584
auggggcagu uggaugcccu uagccugagg cauuuauugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaaca gaaaacggaa acccagaag                              99


<210>  585
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  585
auggggcagu uggaugcccu uagccugagg cauuuauugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacc uuugcagacu ggccccaga                              99


<210>  586
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  586
auggggcagu uggaugcccu uagccugagg cauuuauugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacg cgcccuccga ucuggggug                              99


<210>  587
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  587
auggggcagu uggaugcccu uagccugagg cauuuauugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacc auguccuagc accucuggg                              99


<210>  588
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  588
auggggcagu uggaugcccu uagccugagg cauuuauugc acucgggaag uaccuuuucu       60

cagaaauggu acauccaacg ggggcggggg ggagaaaaa                              99


<210>  589
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  589
guuguagucg accugaaucu guggggugcu uacagggagc aguuaacugg cugggg           56


<210>  590
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  590
guuguagucg accugaaucu guggggugcu uacaggagag augcuaagug acuugc           56


<210>  591
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  591
guuguagucg accugaaucu guggggugcu uacaggcaga gaugcuaagu gacuug           56


<210>  592
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  592
gauauaucuu guaugcauau guagguugug aguuguaucc cuucaggaaa aa               52


<210>  593
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  593
guugcaauga acguaugugc augaggugug aggcggggcc ucuggcuccc cc               52


<210>  594
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  594
guugcaauga acguaugugc augaggugug agaucuguga gaggcagaag au               52


<210>  595
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  595
guugcagaac ccgaauagac gaaugaagga augcaacgaa aguucugugc caagaag          57


<210>  596
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  596
guugcagaac ccgaauagac gaaugaagga augcaacgcc uacggcgacg ggagggu          57


<210>  597
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  597
guugcagaac ccgaauagac gaaugaagga augcaacaau gcuaccuagc agaagga          57


<210>  598
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  598
gaugugaacg accuuuuuuu gcgguguacu ucgagguauu aaauacucgu auugcu           56


<210>  599
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  599
uauugucgcc gauaagguug cgauagccua cgggcaacug cgcaacuggc ggcgauaggc       60

cgacucgaac ggccugaagg ggccuuacgg ccugaaaaug agaaggcaca uauaagagaa      120

aauucguuuu ccguuguguu cgcucuaucc aauacacgca aauu                       164


<210>  600
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  600
gcugcacugc accgcccauu gauggugugc ucuagguauu aaauacucgu auugcu           56


<210>  601
<211>  155
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  601
accgaggccg cgaaaaacac aacgcuagcc gaaaggcaau cgcgggugcg cggccgaagg       60

ccgacuagag cggccugaag guugagaagc gugcauguaa acggcagaaa aaaugccuuu      120

uguacgcgcu caccgaacac gucugagcgg uuuuu                                 155


<210>  602
<211>  149
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  602
ggccgaccug uacggccuga aggaugagaa ggcacauaua aguggaaaau ugcuucccgu       60

uguguucgcu caccagguac uccuuaauug aaagcugcaa gagcuccuaa uuugaggggu      120

gcauacaggu auuaaauacu cguauugcu                                        149


<210>  603
<211>  216
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  603
aguaugaggc cgccgauaaa cguuucgcua gccugacagg caaucgcgaa cgggcggcug       60

aaggccgacc uguacggccu gaaggaugag aaggcacaua uaaguggaaa auugcuuccc      120

guuguguucg cucaccaggu acuccuuaau uuuuuugaaa gcugcaagag cuccuaauuu      180

gaggggugca uacagguauu aaauacucgu auugcu                                216


<210>  604
<211>  203
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  604
ugaaauauug auugaggucg ccguuuacgu ugcgucacaa gggcgcgcgg gcgaccgaag       60

gccgaucugu acggccugca gguugagaag gcacauauua gaggaaaauu gcuucccuuu      120

guguucgcuc accgaguauu ccuuguuuuu ugcggcaaga aacugucuua auuguuuucu      180

ggggcagaag uuacagccca aca                                              203


<210>  605
<211>  176
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  605
uauugcgcua gccauaaugg caaucgcgua caggcaacug aaggccgacc uguacggccu       60

uaagguugag aaggcacaug uaaguggaaa aaugcuuucc cguuguguuc gcucaccaag      120

cacacacguu uuuuugaaau guggggugcu uacagguauu aaauacucgu auugcu          176


<210>  606
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  606
gaaggccgac cuguacggcc uuaagguuga gaaggcacau guaaguggaa aaaugcuuuc       60

ccguuguguu cgcucaccaa gcacacacgu uuuuuugaaa uguggggugc uuacagguau      120

uaaauacucg uauugcu                                                     137


<210>  607
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  607
aaggccgacc tgtacggcct taaggttgag aaggcacatg tcagtggaaa aatgctttcc       60

ctttgtgttc gctcaccaag cacacgcggt ttttt                                  95


<210>  608
<211>  222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  608
atgaggttca ttgaaaagtt aactgaggtt gtcgtaaatg ttgcgctagc cataatggca       60

atcgcgtaca ggcaactgaa ggccgacctg tacggcctta aggttgagaa ggcacatgtc      120

agtggaaaaa tgctttccct ttgtgttcgc tcaccaagca cacgcggttt ttttaatgca      180

ataattgctt caaaggcctg taaaataatg atttacaacg aa                         222


<210>  609
<211>  226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  609
atgctcattg aaaagttaaa tgaggtcgcc atcaatgttt cgctaacctt taaggtaatc       60

gcgggcaggc gactgaaggc cgacctgtac ggccttaagg ctgagaaggc acatgtaagt      120

ggaaaaatgc tttcccgttg tgttcgctca ccaagcacat ttgttttttt aatgcagtta      180

ttgctccaac agcctgtaaa atctccagtt acaacagata gggttg                     226


<210>  610
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  610
ggggcaguug guugcccuua gccugaggca uuuauugcac ucgggaagua ccauuuccaa       60

uuaaacaaca gaaaugguac auccaacuau uaaauacucg uauugcu                    107


<210>  611
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  611
gaaggccgac ctgtacggcc ttaaggttga gaaggcacat gtaagtggaa aaatgctttc       60

ccgttgtgtt cgctcaccaa gcacacacgt tttttt                                 96


<210>  612
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  612
aacugccggu aagauuacga uagccgaaag gcaauugcgu augcggcagu uaaggccggc       60

ucgaacggcc ugaagguuga guuuaaaguc acauauaagc ggaaaaauca gauuucccau      120

uguguucgcu caccaauacg cgcaaauuug aaaauguagu ucgagguauu aaauacucgu      180

auugcu                                                                 186


<210>  613
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  cr/sgRNA guide nucleic acid

<400>  613
ggggcaguug gaugcccuua ugcugaggga uuauuccacu cggcaaguac caauaauaau       60

ggaugugaaa agguacaucc aacuauuaaa uacucguauu gcu                        103


<210>  614
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  cr/sgRNA guide nucleic acid

<400>  614
cgggugguug cacauccgaa gggugaggau uuuuucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaacuauu aaauacucgu auugcu                     106


<210>  615
<211>  201
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  615
uauugucgcc gauaagguug cgauagccua cgggcaacug cgcaacuggc ggcgauaggc       60

cgacucgaac ggccugaagg ggccuuacgg ccugaaaaug agaaggcaca uauaagagaa      120

aauucguuuu ccguuguguu cgcucuaucc aauacacgca aauugaaagu guacuucgag      180

guauuaaaua cucguauugc u                                                201


<210>  616
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  616
gggguuguug gaaacccuua ugcugaggga uuauuccacu cgguaaguac cuuaaauagu       60

uauagaaaga uguaaaucau cuauaaaaga aagguacauc caaccucaug acgcugcggc      120

ugug                                                                   124


<210>  617
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  617
gcuguaaguc auggaaaaau ggugaguaca uccaacuauu aaauacucgu auugcu           56


<210>  618
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  618
auaggaauua uccuaugggg caguugguug uccuuagccu gaggcauuua uugcacucgg       60

gaaguacuuu cgacauuaac                                                   80


<210>  619
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  619
uauggggcag uugguugucc uuagccugag gcauuuauug cacucgggaa guacuuucga       60

cauuaac                                                                 67


<210>  620
<211>  122
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  620
auaggaauua uccuaugggg caguugguug uccuuagccu gaggcauuua uugcacucgg       60

gaaguacuuu cgacauuaac gaaaauggug aguacaucca acuauuaaau acucguauug      120

cu                                                                     122


<210>  621
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  621
uauggggcag uugguugucc uuagccugag gcauuuauug cacucgggaa guacuuucga       60

cauuaacgaa aauggugagu acauccaacu auuaaauacu cguauugcu                  109


<210>  622
<211>  61
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TracrRNA guide nucleic acid

<400>  622
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

a                                                                       61


<210>  623

<400>  623
000

<210>  624
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Repeat sequence guide nucleic acid

<400>  624
ugguauaucc aac                                                          13


<210>  625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence guide nucleic acid

<400>  625
gugccuuagu uucuucaucu                                                   20


<210>  626
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  626
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua uauccaacgu gccuuaguuu cuucaucu                               98


<210>  627
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TracrRNA guide nucleic acid

<400>  627
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accau            55


<210>  628
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Repeat Sequence guide nucleic acid

<400>  628
uacauccaac                                                              10


<210>  629
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  629
ucuaggcgcc cgcuaaguuc                                                   20


<210>  630
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Repeat Sequence guide nucleic acid

<400>  630
ugguacaucc aac                                                          13


<210>  631
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  631
cgugcuguuu ccuccccaca                                                   20


<210>  632
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  632
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaaccg ugcuguuucc uccccaca                               98


<210>  633
<211>  48
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TracrRNA guide nucleic acid

<400>  633
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucggga                    48


<210>  634

<400>  634
000

<210>  635
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence

<400>  635
cgugcuguuu ccuccccacg                                                   20


<210>  636
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  636
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaga aaaaccgugc       60

uguuuccucc ccacg                                                        75


<210>  637
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TracrRNA guide nucleic acid

<400>  637
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uacc             54


<210>  638

<400>  638
000

<210>  639
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  639
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccgaaaau       60

ccaaccgugc uguuuccucc ccacg                                             85


<210>  640
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TracrRNA guide nucleic acid

<400>  640
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

ca                                                                      62


<210>  641
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Repeat Sequence guide nucleic acid

<400>  641
agguacaucc aac                                                          13


<210>  642
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  642
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaaaggu acauccaacc gugcuguuuc cuccccacg                              99


<210>  643

<400>  643
000

<210>  644
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  644
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaaccaa cucuaggcgc ccgcuaaguu c                                      91


<210>  645
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Repeat Sequence guide nucleic acid

<400>  645
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua cauccaac                                                     78


<210>  646
<211>  79
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Repeat Sequence guide nucleic acid

<400>  646
auggggcagu ugguugcccu uagccugagg aauuuaauuc acucgggaag uaccuuucuc       60

augaaauggu acauccaac                                                    79


<210>  647
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  647
ccccccacuc cccgcugcug                                                   20


<210>  648
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  648
aaguggcauc cucucugagc                                                   20


<210>  649
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  649
cuuccucguc ugcagccaca                                                   20


<210>  650
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  650
acuuuuccug uuuucucucu                                                   20


<210>  651
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  651
gguuccucgg ugacccuaga                                                   20


<210>  652
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  652
gugacccuag aaauuggagc                                                   20


<210>  653
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  653
ucugcagcca cagaauaugg                                                   20


<210>  654
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  654
aggagccaca gagcauugag                                                   20


<210>  655
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  655
gaggagggcg ggagacgagc                                                   20


<210>  656
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  656
ucucccgccc uccuccgaca                                                   20


<210>  657
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  657
ccaguuagag acuccgcgga                                                   20


<210>  658
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  658
cucugaucua gaccuaguua                                                   20


<210>  659
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  659
cgccggaagu aggacagagg                                                   20


<210>  660
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  660
aaaggagcga ggacucuuca                                                   20


<210>  661
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  661
cuccuuucga uuucuugucc                                                   20


<210>  662
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  662
auuucuuguc cugacacugg                                                   20


<210>  663
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  663
gaacaaggca aaggcuauaa                                                   20


<210>  664
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  664
aguuauaaua guguguggac                                                   20


<210>  665
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  665
aauauuagug uacuuuagac                                                   20


<210>  666
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  666
uugagccccu uccucgcugc                                                   20


<210>  667
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  667
aagguacaug ugcaggaugu                                                   20


<210>  668
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  668
gcaaccagua gcccuugcgu                                                   20


<210>  669
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  669
cacuuucuuu cuuuguccuu                                                   20


<210>  670
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  670
guguucagug gauuagaaac                                                   20


<210>  671
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  671
gagaagaagc ugcuacaucu                                                   20


<210>  672
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  672
uuaacaaaua uuauuagcag                                                   20


<210>  673
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  673
uccuaccccc accccauccc                                                   20


<210>  674
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  674
gagauggaca auggcccggg                                                   20


<210>  675
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  675
cuccguguac cucuguuccu                                                   20


<210>  676
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  676
guggagaaga uugaauucag                                                   20


<210>  677
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  677
uacggggugc ucuccaagaa                                                   20


<210>  678
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  678
ugggguaaaa aggacaagag                                                   20


<210>  679
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  679
aaaaggcgga cgcacuccgg                                                   20


<210>  680
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  680
ggggagggac uccguccaga                                                   20


<210>  681
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  681
gagaccauau ucuguggcug                                                   20


<210>  682
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  682
agguguauag guggaaagac                                                   20


<210>  683
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  683
uucucuucgg guuccucggu                                                   20


<210>  684
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  684
gagcaaauua cgauugaagu                                                   20


<210>  685
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  685
cgauugaagu uuagaaacau                                                   20


<210>  686
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  686
aaguuuagaa acaugguugg                                                   20


<210>  687
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  687
ucggaggagg gcgggagacg                                                   20


<210>  688
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  688
aucucuccug cggguaaaaa                                                   20


<210>  689
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  689
gcuuuucccu uccuucccuc                                                   20


<210>  690
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  690
acauuagcuu uucccuuccu                                                   20


<210>  691
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  691
acuaggucua gaucagagcg                                                   20


<210>  692
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  692
gcgccaaagg auggcuucuc                                                   20


<210>  693
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  693
ggagaagcca uccuuuggcg                                                   20


<210>  694
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  694
gggaacuaau cucaacgcug                                                   20


<210>  695
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  695
gucaaguuug ccuugucaag                                                   20


<210>  696
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  696
gccagccuug ccuugaccaa                                                   20


<210>  697
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  697
gucaaggcaa ggcuggccaa                                                   20


<210>  698
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  698
agauagugug gggaaggggc                                                   20


<210>  699
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  699
gcagugguuu cuaaggaaaa                                                   20


<210>  700
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  700
gagaaaaacu ggaaugacug                                                   20


<210>  701
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  701
guacaugcuu uagcuuuaaa                                                   20


<210>  702
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  702
agagauaaug gcaaaaguca                                                   20


<210>  703
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  703
guucggagaa gaagcugcua                                                   20


<210>  704
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  704
ugcgggggaa gauguagcag                                                   20


<210>  705
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  705
ucuuuuagaa uuugggagcc                                                   20


<210>  706
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  706
ggucauuguc uuuuagaauu                                                   20


<210>  707
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  707
ugggggaggg ccggagcugg                                                   20


<210>  708
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  708
ugggggaggg ccggagcugg                                                   20


<210>  709
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  709
ugggggaggg ccggagcugg                                                   20


<210>  710
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  710
gccagcgccg ccaggcucac                                                   20


<210>  711
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN10 linker

<400>  711

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 
1               5                   10  


<210>  712
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  712

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  713
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion effector sequences

<400>  713

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ser Lys Arg Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asn Val Leu Asn Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Asp Phe Tyr Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Ile Asn 
                165     


<210>  714
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion effector sequences

<400>  714

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Tyr Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Ser Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Arg Phe Phe Arg Met Pro Arg Arg Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  715
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  715
cuccguggcc uuagcugugc                                                   20


<210>  716
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  716
gugaggaagc accugagccc                                                   20


<210>  717
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  717
cugcaucccu gcucaggcua                                                   20


<210>  718
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  718
uccuggagag aacaggcaau                                                   20


<210>  719
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  719
cagcucucag ccaccuuccc                                                   20


<210>  720
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  720
ggaccuaaag aaacuggagu                                                   20


<210>  721
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  721
accagcuuga caucacagga                                                   20


<210>  722
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  722
gaacccaauc acugacaggu                                                   20


<210>  723
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TRAC_5

<400>  723
gugaauaggc agacagacuu                                                   20


<210>  724
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CIITA_15

<400>  724
cagaugcagu uauuguacaa                                                   20


<210>  725
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  725
cgagcacagc uaaggccacg                                                   20


<210>  726
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  726
cuccaucagc cacugaccug                                                   20


<210>  727
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide Spacer Sequences

<400>  727
gggacgaggg ugucucgcag                                                   20


<210>  728
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.286251

<400>  728

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Cys Thr Glu Gly 
1               5                   10                  15      


Leu Ser Asp Gln Glu Arg Lys Asp Gln Trp Asn Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Arg Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Gly Ser Met Val Arg Leu Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Arg Ala Leu Glu Lys Ala Lys Lys Gln Lys Ala Pro 
65                  70                  75                  80  


Asp Glu Glu Val Ile Ala Glu Leu Ser Gln Gln Val Ala Thr Ala Glu 
                85                  90                  95      


Gln Glu Met Asp Glu Gln Ala Lys Ala Ile Cys Gln Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Thr Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Gly Gln Ile Leu Thr Cys Leu Arg Gln Gly Val Phe Ser 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ser Ile 
145                 150                 155                 160 


Arg Thr Tyr Lys Lys Gly Met Pro Ile Pro Phe Pro Trp Asn Asp Ser 
                165                 170                 175     


Leu Arg Ile Gly Phe Glu Asp Gly Glu Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Arg Phe Asp Phe Gly Lys Asp Arg Ser Asn Asn Cys 
        195                 200                 205             


Leu Ile Val Gln Arg Cys Met Lys Met Asp Lys Asp Tyr Glu Gly Asp 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Met Val Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Pro Lys Phe Phe Leu Leu Leu Val Val Asn Ile Pro Gln Glu Arg Val 
                245                 250                 255     


Glu Leu Asn Lys Asn Ile Val Val Gly Val Ala Leu Gly Ile Asn Ala 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Thr Thr Pro Glu Arg Lys Gln Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Glu Arg Met Ala Phe Gln Arg Arg Phe 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Lys Gly Thr Thr Gly Gly Arg Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu Gln Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Ile Asp Phe Ala 
            340                 345                 350         


Val Lys Ala Arg Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Thr Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile Arg Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly His Gln Gly Phe Arg Glu Gly Ile Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Lys Phe Gly Glu Lys Glu His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Glu Ile Ile 
    450                 455                 460                 


Lys Asn Asn Glu Glu 
465                 


<210>  729
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  729

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Ala Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  730
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  730

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asn Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  731
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasM.19952

<400>  731

Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly 
1               5                   10                  15      


Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile 
            20                  25                  30          


Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr 
        35                  40                  45              


Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr 
    50                  55                  60                  


Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro 
65                  70                  75                  80  


Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu 
                85                  90                  95      


Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu 
            100                 105                 110         


Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr 
        115                 120                 125             


Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala 
    130                 135                 140                 


Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile 
145                 150                 155                 160 


Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser 
                165                 170                 175     


Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn 
            180                 185                 190         


Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu 
    210                 215                 220                 


Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys 
225                 230                 235                 240 


Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val 
                245                 250                 255     


Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val 
            260                 265                 270         


Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly 
        275                 280                 285             


Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr 
    290                 295                 300                 


Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala 
305                 310                 315                 320 


Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp 
                325                 330                 335     


Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala 
            340                 345                 350         


Val Lys Ser His Ala Ala Thr Ile His Met Gln Asp Leu Ser Gly Phe 
        355                 360                 365             


Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu 
    370                 375                 380                 


Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala 
385                 390                 395                 400 


Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser 
                405                 410                 415     


Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr 
            420                 425                 430         


Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His 
        435                 440                 445             


Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile 
    450                 455                 460                 


Lys Lys Asn Glu 
465             


<210>  732
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion effector sequences

<400>  732

Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His Ile 
1               5                   10                  15      


Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr Leu 
            20                  25                  30          


Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp 
        35                  40                  45              


Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly 
    50                  55                  60                  


Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser 
65                  70                  75                  80  


Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser 
                85                  90                  95      


Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe 
            100                 105                 110         


Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile 
        115                 120                 125             


Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp 
    130                 135                 140                 


Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys 
145                 150                 155                 160 


Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp Asp 
                165                 170                 175     


Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala Ile 
            180                 185                 190         


Leu Gln Asn Gln Gly Asn 
        195             


<210>  733

<400>  733
000

<210>  734
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN40

<400>  734

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
1               5                   10                  15      


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 
            20                  25                  30          


Gly Ser Ala Pro Gly Ser Pro Ala 
        35                  40  


<210>  735
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  XTEN80

<400>  735

Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 
1               5                   10                  15      


Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 
            20                  25                  30          


Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
        35                  40                  45              


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 
65                  70                  75                  80  


<210>  736
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  736
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uauuucauug agcaacagaa aggguacauc caacucuagg cgcccgcuaa      120

guuc                                                                   124


<210>  737
<211>  104
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  737
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uauuucauug agcaacagaa aggguacauc caac                       104


<210>  738
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  738
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uauuucauug agcaacagaa aggguacauc caacggacaa aguuuagggc      120

gucg                                                                   124


<210>  739
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  739
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uauuucauug agcaacagaa aggguacauc caacauaagc gucagagcgc      120

cgag                                                                   124


<210>  740
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  740
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uauuucauug agcaacagaa aggguacauc caaccuccgu ggccuuagcu      120

gugc                                                                   124


<210>  741
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  741
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uauuucauug agcaacagaa aggguacauc caacgaugga ugaaacccag      120

acac                                                                   124


<210>  742
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  742
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uauuucauug agcaacagaa aggguacauc caacugauga uucugcccuc      120

cucc                                                                   124


<210>  743
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  743
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uauuucauug agcaacagaa aggguacauc caacaguaca ucuucaagcc      120

aucc                                                                   124


<210>  744
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  744
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uauuucauug agcaacagaa aggguacauc caacgaccua agggagagcc      120

agga                                                                   124


<210>  745
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  745
aauaggauuu auccuauggg gcaguugguu gcccuuagcc ugaggcauuu auugcacucg       60

ggaaguaccu uauuucauug agcaacagaa aggguacauc caacggaaga uucugaugug      120

gaaa                                                                   124


<210>  746
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  746
ggggcaguug gaugcccuua ugcugaggga uuauuccacu cggcaaguac caauaauaau       60

ggaugugaaa agguacaucc aacugagugg ggcagugggg gcg                        103


<210>  747
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  747
ggggcaguug gaugcccuua ugcugaggga uuauuccacu cggcaaguac caauaauaau       60

ggaugugaaa agguacaucc aac                                               83


<210>  748
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  748
ggggcaguug gaugcccuua ugcugaggga uuauuccacu cggcaaguac caauaauaau       60

ggaugugaaa agguacaucc aacucggggg gcggggggga gaa                        103


<210>  749
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  749
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaaccuca cgucauccag cagaga                     106


<210>  750
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  750
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaac                                            86


<210>  751
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  751
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaacuugu gcuguaggaa gcucau                     106


<210>  752
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  752
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaacauga gagcaagugg gcugau                     106


<210>  753
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  753
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaacaggu ggcagcggcu ugaucc                     106


<210>  754
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  754
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaacgcca aaggcaugug agguac                     106


<210>  755
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  755
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaacgggc agcuggugga auuuuu                     106


<210>  756
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  756
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaaccagg uugagaacuu guugcu                     106


<210>  757
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  757
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaacuccc gacccucccg ucgccg                     106


<210>  758
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  758
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaacggac gagccuaccc gucccc                     106


<210>  759
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  759
cgggugguug cacauccgaa gggugaggau uuauucacuc acuaauacua caaauggaaa       60

aauuuaaagg aaaauguaaa ugcaacucgg ggggcggggg ggagaa                     106


<210>  760
<211>  214
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  760
ugaaauauug auugaggucg ccguuuacgu ugcgucacaa gggcgcgcgg gcgaccgaag       60

gccgaucugu acggccugca gguugagaag gcacauauua gaggaaaauu gcuucccuuu      120

guguucgcuc accgaguauu ccuuguuauu ugcggcaaga aacugucuua auuguuugaa      180

agggugcaua caggaccuca aauuccuccu caga                                  214


<210>  761
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  761
ugaaauauug auugaggucg ccguuuacgu ugcgucacaa gggcgcgcgg gcgaccgaag       60

gccgaucugu acggccugca gguugagaag gcacauauua gaggaaaauu gcuucccuuu      120

guguucgcuc accgaguauu ccuuguuauu ugcggcaaga aacugucuua auuguuugaa      180

agggugcaua cagg                                                        194


<210>  762
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  762
aagcaaccgc guacacgcgg acgaacggcc gaccugcucg gccugaaggu ugagaagguu       60

auguauaaga ggagaaaauc ccccuucaua aucgcucacc aagcucccaa uuuacauauu      120

uugaaagggc gcaugcagga ccucaaauuc cuccucaga                             159


<210>  763
<211>  139
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  763
aagcaaccgc guacacgcgg acgaacggcc gaccugcucg gccugaaggu ugagaagguu       60

auguauaaga ggagaaaauc ccccuucaua aucgcucacc aagcucccaa uuuacauauu      120

uugaaagggc gcaugcagg                                                   139


<210>  764
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  764
uauugcgcua gccauaaugg caaucgcgua caggcaacug aaggccgacc uguacggccu       60

uaagguugag aaggcacaug uaaguggaaa aaugcuuucc cguuguguuc gcucaccaag      120

cacacacguu ugaaaugugg ggugcuuaca ggauccaaca gccaggggga cu              172


<210>  765
<211>  152
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  765
uauugcgcua gccauaaugg caaucgcgua caggcaacug aaggccgacc uguacggccu       60

uaagguugag aaggcacaug uaaguggaaa aaugcuuucc cguuguguuc gcucaccaag      120

cacacacguu ugaaaugugg ggugcuuaca gg                                    152


<210>  766
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  766
uauugcgcua gccauaaugg caaucgcgua caggcaacug aaggccgacc uguacggccu       60

uaagguugag aaggcacaug uaaguggaaa aaugcuuucc cguuguguuc gcucaccaag      120

cacacacguu ugaaaugugg ggugcuuaca ggauccugug ugccccugau gc              172


<210>  767
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  767
uauugcgcua gccauaaugg caaucgcgua caggcaacug aaggccgacc uguacggccu       60

uaagguugag aaggcacaug uaaguggaaa aaugcuuucc cguuguguuc gcucaccaag      120

cacacacguu ugaaaugugg ggugcuuaca ggaccucaaa uuccuccuca ga              172


<210>  768
<211>  212
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  768
aguaugaggc cgccgauaaa cguuucgcua gccugacagg caaucgcgaa cgggcggcug       60

aaggccgacc uguacggccu gaaggaugag aaggcacaua uaaguggaaa auugcuuccc      120

guuguguucg cucaccaggu acuccuuaau uugaaagcug caagagcucc uaauuugagg      180

ggugcauaca ggagaaagag agaguagcgc ga                                    212


<210>  769
<211>  192
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  769
aguaugaggc cgccgauaaa cguuucgcua gccugacagg caaucgcgaa cgggcggcug       60

aaggccgacc uguacggccu gaaggaugag aaggcacaua uaaguggaaa auugcuuccc      120

guuguguucg cucaccaggu acuccuuaau uugaaagcug caagagcucc uaauuugagg      180

ggugcauaca gg                                                          192


<210>  770
<211>  212
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  770
aguaugaggc cgccgauaaa cguuucgcua gccugacagg caaucgcgaa cgggcggcug       60

aaggccgacc uguacggccu gaaggaugag aaggcacaua uaaguggaaa auugcuuccc      120

guuguguucg cucaccaggu acuccuuaau uugaaagcug caagagcucc uaauuugagg      180

ggugcauaca gguacuaugg gaucaagccg cu                                    212


<210>  771
<211>  212
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  771
aguaugaggc cgccgauaaa cguuucgcua gccugacagg caaucgcgaa cgggcggcug       60

aaggccgacc uguacggccu gaaggaugag aaggcacaua uaaguggaaa auugcuuccc      120

guuguguucg cucaccaggu acuccuuaau uugaaagcug caagagcucc uaauuugagg      180

ggugcauaca ggaccucaaa uuccuccuca ga                                    212


<210>  772
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  772
aacugccggu aagauuacga uagccgaaag gcaauugcgu augcggcagu uaaggccggc       60

ucgaacggcc ugaagguuga guuuaaaguc acauauaagc ggaaaaauca gauuucccau      120

uguguucgcu caccaauacg cgcaaauuug aaaauguagu ucgaggucca ggccuaagga      180

aggagu                                                                 186


<210>  773
<211>  166
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  773
aacugccggu aagauuacga uagccgaaag gcaauugcgu augcggcagu uaaggccggc       60

ucgaacggcc ugaagguuga guuuaaaguc acauauaagc ggaaaaauca gauuucccau      120

uguguucgcu caccaauacg cgcaaauuug aaaauguagu ucgagg                     166


<210>  774
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  774
aacugccggu aagauuacga uagccgaaag gcaauugcgu augcggcagu uaaggccggc       60

ucgaacggcc ugaagguuga guuuaaaguc acauauaagc ggaaaaauca gauuucccau      120

uguguucgcu caccaauacg cgcaaauuug aaaauguagu ucgagguugg ugaaguaggg      180

ccuccu                                                                 186


<210>  775
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  775
aacugccggu aagauuacga uagccgaaag gcaauugcgu augcggcagu uaaggccggc       60

ucgaacggcc ugaagguuga guuuaaaguc acauauaagc ggaaaaauca gauuucccau      120

uguguucgcu caccaauacg cgcaaauuug aaaauguagu ucgaggaauu ccggguaucc      180

caggag                                                                 186


<210>  776
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  776
aacugccggu aagauuacga uagccgaaag gcaauugcgu augcggcagu uaaggccggc       60

ucgaacggcc ugaagguuga guuuaaaguc acauauaagc ggaaaaauca gauuucccau      120

uguguucgcu caccaauacg cgcaaauuug aaaauguagu ucgagguuca uugcagaaag      180

agacau                                                                 186


<210>  777
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  777
aacugccggu aagauuacga uagccgaaag gcaauugcgu augcggcagu uaaggccggc       60

ucgaacggcc ugaagguuga guuuaaaguc acauauaagc ggaaaaauca gauuucccau      120

uguguucgcu caccaauacg cgcaaauuug aaaauguagu ucgaggagau cacgaggaau      180

acaaca                                                                 186


<210>  778
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  778
aacugccggu aagauuacga uagccgaaag gcaauugcgu augcggcagu uaaggccggc       60

ucgaacggcc ugaagguuga guuuaaaguc acauauaagc ggaaaaauca gauuucccau      120

uguguucgcu caccaauacg cgcaaauuug aaaauguagu ucgaggcagc cgggaggagc      180

agcaag                                                                 186


<210>  779
<211>  190
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  779
accgaggccg cgaaaaacac aacgcuagcc gaaaggcaau cgcgggugcg cggccgaagg       60

ccgacuagag cggccugaag guugagaagc gugcauguaa acggcagaaa aaaugccuuu      120

uguacgcgcu caccgaacac gucugagcgg uuugaaaggu gugcucuagg acuaugggau      180

caagccgcug                                                             190


<210>  780
<211>  170
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  780
accgaggccg cgaaaaacac aacgcuagcc gaaaggcaau cgcgggugcg cggccgaagg       60

ccgacuagag cggccugaag guugagaagc gugcauguaa acggcagaaa aaaugccuuu      120

uguacgcgcu caccgaacac gucugagcgg uuugaaaggu gugcucuagg                 170


<210>  781
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  781
gggguuguug gaaacccuua ugcugaggga uuauuccacu cgguaaguac cuuaaauagu       60

uauagaaaga uguaaaucau cuauaaaaga aagguacauc caacgccugg aggcuaucca      120

gcgu                                                                   124


<210>  782
<211>  104
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  782
gggguuguug gaaacccuua ugcugaggga uuauuccacu cgguaaguac cuuaaauagu       60

uauagaaaga uguaaaucau cuauaaaaga aagguacauc caac                       104


<210>  783
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  783
gggguuguug gaaacccuua ugcugaggga uuauuccacu cgguaaguac cuuaaauagu       60

uauagaaaga uguaaaucau cuauaaaaga aagguacauc caacacuuuc cauucucugc      120

ugga                                                                   124


<210>  784
<211>  131
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  784
aagauaugaa uaggaguauu ccuauggggc aguugguugc ccuuagccug agguauuuaa       60

ugcacucggg aaguacuuuc aacaguaucc guuagaaaag guacauccaa cguguugcug      120

gagggggccu u                                                           131


<210>  785
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  785
aagauaugaa uaggaguauu ccuauggggc aguugguugc ccuuagccug agguauuuaa       60

ugcacucggg aaguacuuuc aacaguaucc guuagaaaag guacauccaa c               111


<210>  786

<400>  786
000

<210>  787

<400>  787
000

<210>  788

<400>  788
000

<210>  789

<400>  789
000

<210>  790

<400>  790
000

<210>  791

<400>  791
000

<210>  792

<400>  792
000

<210>  793
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Prosite motif

<400>  793

Lys Gly Glu Thr Phe Val Phe Leu Leu Gly Arg Lys Asn Trp Ser Arg 
1               5                   10                  15      


Thr Tyr Tyr Phe Glu Asp Gln Leu Gln Asn Thr Met Lys Ile Glu Lys 
            20                  25                  30          


Tyr Lys Ala Lys Ala Glu Tyr Ala Gly Ile Lys Val Val Glu Lys Tyr 
        35                  40                  45              


Ile Val Asn Arg Pro Ala Lys Tyr Thr Ser Gln Arg Lys Arg Thr Cys 
    50                  55                  60                  


Ser Trp Lys Cys Gly Tyr Gln His Ile Gly Asp Lys Phe Arg Asp Asn 
65                  70                  75                  80  


Phe 
    


<210>  794
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Prosite motif

<400>  794

Thr Gln Leu Asn His Leu Arg Gln Tyr Phe Ser Arg Glu Ala Val Leu 
1               5                   10                  15      


Ile Val Asp Glu Asn Phe Tyr Ala Val Lys Asn His Gly Ala Gly Ala 
            20                  25                  30          


Thr Ile Gln His Met Glu Asp Asn Leu Ser Gly 
        35                  40              


<210>  795
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Prosite motif

<400>  795

Leu Asn Asp Lys Pro Asn Lys Glu Ile Lys Val Ile Val Leu Gly Val 
1               5                   10                  15      


Asp Leu Gly Ile Val Asn Ser Val Tyr Pro Leu Ala Tyr Ala Val Ala 
            20                  25                  30          


Ser Thr Val 
        35  


<210>  796
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Prosite motif

<400>  796

Gln Trp Gly Asn Leu Leu Tyr His Ile Asn Asp Asn Leu Tyr Lys Arg 
1               5                   10                  15      


Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr Leu Asp Asp Glu His Val 
            20                  25                  30          


Ser Ser Met Val Arg Leu Met Lys His Ala Asp Glu Tyr Leu 
        35                  40                  45      


<210>  797
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Prosite motif

<400>  797

Val Leu Lys Arg Gly Glu Lys Arg Ser Ala Ile Leu Pro Arg Asn Thr 
1               5                   10                  15      


Ser Tyr Phe Lys Arg Lys Ser Gly Asp Asn Met Gln Pro Ile Leu Pro 
            20                  25                  30          


Phe Ile His Pro Trp Cys 
        35              


<210>  798
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Prosite motif

<400>  798

Asn His Ala Asp Tyr Asn Ala Ala Ser Arg Gln Asn Ile Leu Ala Ser 
1               5                   10                  15      


Ile Asn Ser Lys Lys Asp Ile Asp 
            20                  


<210>  799
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Prosite motif

<400>  799

Arg Tyr Leu Cys Gly Lys Gly Thr Thr Gly Arg Gly Ile Gly His Lys 
1               5                   10                  15      


Gly Arg Lys Lys Arg Lys Arg Leu Glu Pro Leu Ile Glu Tyr Arg Lys 
            20                  25                  30          


Leu Arg Glu Asp Gly 
        35          


<210>  800
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS Sequence

<400>  800

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Glu Phe 
        


<210>  801
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-Myc NLS

<400>  801

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  802

<400>  802
000

<210>  803

<400>  803
000

<210>  804

<400>  804
000

<210>  805
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = Tryptophan/ Phenylalanine/ Tyrosine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  805

Lys Arg Xaa Xaa Xaa Xaa Ala Phe 
1               5               


<210>  806

<400>  806
000

<210>  807
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS Sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = Lysine/ Arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = Tryptophan/ Phenylalanine/ Tyrosine

<400>  807

Leu Gly Lys Arg Xaa Xaa 
1               5       


<210>  808
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS Sequence


<220>
<221>  misc_feature
<222>  (3)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  808

Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Arg Lys 
1               5                   10                  15      


Arg 
    


<210>  809
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS Sequence


<220>
<221>  misc_feature
<222>  (3)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = Lysine/ Arginine

<400>  809

Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Arg Xaa 
1               5                   10                  15      


Xaa 
    


<210>  810
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SV40 NLS

<400>  810

Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala Ala 
1               5                   10                  15  


<210>  811
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV cleavage

<400>  811

Glu Asn Leu Tyr Phe Gln Ser Asn Ala 
1               5                   


<210>  812
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full Uncleaved TEV-Cleavable and MBP tag sequence of CasM. 19952

<400>  812

Met Lys Ser Ser His His His His His His His His His His Gly Ser 
1               5                   10                  15      


Ser Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp 
            20                  25                  30          


Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp 
        35                  40                  45              


Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys 
    50                  55                  60                  


Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp 
65                  70                  75                  80  


Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu 
                85                  90                  95      


Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp 
            100                 105                 110         


Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val 
        115                 120                 125             


Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro 
    130                 135                 140                 


Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys 
145                 150                 155                 160 


Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp 
                165                 170                 175     


Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly 
            180                 185                 190         


Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala 
        195                 200                 205             


Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala 
    210                 215                 220                 


Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr 
225                 230                 235                 240 


Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser 
                245                 250                 255     


Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro 
            260                 265                 270         


Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser 
        275                 280                 285             


Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr 
    290                 295                 300                 


Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val 
305                 310                 315                 320 


Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala 
                325                 330                 335     


Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro 
            340                 345                 350         


Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala 
        355                 360                 365             


Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr 
    370                 375                 380                 


Asn Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly 
385                 390                 395                 400 


Ile Glu Glu Asn Leu Tyr Phe Gln Ser Asn Ala Met Pro Thr Ile Thr 
                405                 410                 415     


Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly Leu Ser Glu Glu Gln 
            420                 425                 430         


Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile Asn Asp Asn Leu Tyr 
        435                 440                 445             


Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr Leu Asp Asp His Val 
    450                 455                 460                 


Ser Ser Met Val Arg Met Lys His Ala Glu Tyr Leu Ser Leu Leu Lys 
465                 470                 475                 480 


Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro Asp Ala Asp Ala Ile 
                485                 490                 495     


Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu Lys Glu Met Thr Asp 
            500                 505                 510         


Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu Met Ser Thr Gln Ser 
        515                 520                 525             


Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr Asn Ile Phe Ala Lys 
    530                 535                 540                 


Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala Thr Phe Asn Ser Asp 
545                 550                 555                 560 


Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile Arg Asn Tyr Lys Lys 
                565                 570                 575     


Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser Leu Arg Ile Glu Lys 
            580                 585                 590         


Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn Gly Leu Arg Phe Leu 
        595                 600                 605             


Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg Leu Ile Val Glu Arg 
    610                 615                 620                 


Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu Tyr Lys Leu Cys Asn 
625                 630                 635                 640 


Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys Thr Lys Leu Phe Leu 
                645                 650                 655     


Leu Leu Val Val Lys Ile Pro Gln Glu His Val Glu Leu Asn Lys Lys 
            660                 665                 670         


Val Val Val Gly Val Asp Leu Gly Ile Asn Val Pro Ala Tyr Val Ala 
        675                 680                 685             


Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly Asp Arg Glu His Phe 
    690                 695                 700                 


Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr Lys Ser Leu Gln Arg 
705                 710                 715                 720 


Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala Lys Lys Leu Glu Pro 
                725                 730                 735     


Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp Val His Thr Gln Asn 
            740                 745                 750         


His Leu Phe Ser Arg Glu Val Val Asp Phe Ala Val Lys Ser His Ala 
        755                 760                 765             


Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe Gly Lys Asp Asn Asp 
    770                 775                 780                 


Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu Arg Asn Trp Ser Tyr 
785                 790                 795                 800 


Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala Ala Lys Tyr Gly Ile 
                805                 810                 815     


Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser Lys Thr Cys Ser Trp 
            820                 825                 830         


Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr Phe Ile Cys Glu Asn 
        835                 840                 845             


Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His Ala Asp Tyr Asn Ala 
    850                 855                 860                 


Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile Lys Lys Asn Glu 
865                 870                 875                 


<210>  813
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full cleaved TEV-Cleavable and MBP tag sequence of CasM. 19952

<400>  813

Ser Asn Ala Met Pro Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu 
1               5                   10                  15      


Thr Glu Gly Leu Ser Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu 
            20                  25                  30          


Tyr His Ile Asn Asp Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser 
        35                  40                  45              


Lys Leu Tyr Leu Asp Asp His Val Ser Ser Met Val Arg Met Lys His 
    50                  55                  60                  


Ala Glu Tyr Leu Ser Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln 
65                  70                  75                  80  


Lys Thr Pro Asp Ala Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala 
                85                  90                  95      


Ala Ala Glu Lys Glu Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr 
            100                 105                 110         


Ala Thr Glu Met Ser Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu 
        115                 120                 125             


Leu Glu Thr Asn Ile Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly 
    130                 135                 140                 


Val Phe Ala Thr Phe Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu 
145                 150                 155                 160 


Arg Ala Ile Arg Asn Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp 
                165                 170                 175     


Asp Lys Ser Leu Arg Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg 
            180                 185                 190         


Trp Tyr Asn Gly Leu Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser 
        195                 200                 205             


Asn Asn Arg Leu Ile Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr 
    210                 215                 220                 


Asp Gly Glu Tyr Lys Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg 
225                 230                 235                 240 


Glu Gly Lys Thr Lys Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln 
                245                 250                 255     


Glu His Val Glu Leu Asn Lys Lys Val Val Val Gly Val Asp Leu Gly 
            260                 265                 270         


Ile Asn Val Pro Ala Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys 
        275                 280                 285             


Ala Ile Gly Asp Arg Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln 
    290                 295                 300                 


Arg Arg Tyr Lys Ser Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys 
305                 310                 315                 320 


Gly Arg Ala Lys Lys Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu 
                325                 330                 335     


His Asn Trp Val His Thr Gln Asn His Leu Phe Ser Arg Glu Val Val 
            340                 345                 350         


Asp Phe Ala Val Lys Ser His Ala Ala Thr Ile His Met Glu Asp Leu 
        355                 360                 365             


Ser Gly Phe Gly Lys Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu 
    370                 375                 380                 


Phe Val Leu Arg Asn Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala 
385                 390                 395                 400 


Tyr Lys Ala Ala Lys Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala 
                405                 410                 415     


Tyr Thr Ser Lys Thr Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu 
            420                 425                 430         


Gly Val Thr Phe Ile Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu 
        435                 440                 445             


Lys Val His Ala Asp Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys 
    450                 455                 460                 


Asp Ile Ile Lys Lys Asn Glu 
465                 470     


<210>  814
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full sequence of His and GFP tagged CasM. 19952

<400>  814

Met Lys Ser Ser His His His His His His His Gly Ser Ser Met Pro 
1               5                   10                  15      


Thr Ile Thr Arg Lys Ile Glu Leu Thr Leu Leu Thr Glu Gly Leu Ser 
            20                  25                  30          


Glu Glu Gln Arg Lys Glu Gln Trp Gly Leu Leu Tyr His Ile Asn Asp 
        35                  40                  45              


Asn Leu Tyr Lys Ala Ala Asn Asn Ile Ser Ser Lys Leu Tyr Leu Asp 
    50                  55                  60                  


Asp His Val Ser Ser Met Val Arg Met Lys His Ala Glu Tyr Leu Ser 
65                  70                  75                  80  


Leu Leu Lys Glu Leu Ala Arg Ala Glu Lys Gln Lys Thr Pro Asp Ala 
                85                  90                  95      


Asp Ala Ile Ala Glu Leu Arg Lys Lys Val Ala Ala Ala Glu Lys Glu 
            100                 105                 110         


Met Thr Asp Gln Glu His Ala Ile Cys Lys Tyr Ala Thr Glu Met Ser 
        115                 120                 125             


Thr Gln Ser Leu Ser Tyr Arg Phe Ala Thr Glu Leu Glu Thr Asn Ile 
    130                 135                 140                 


Phe Ala Lys Ile Leu Asp Cys Leu Lys Gln Gly Val Phe Ala Thr Phe 
145                 150                 155                 160 


Asn Ser Asp Ala Arg Asp Val Lys Arg Gly Glu Arg Ala Ile Arg Asn 
                165                 170                 175     


Tyr Lys Lys Gly Met Pro Ile Pro Phe Ala Trp Asp Lys Ser Leu Arg 
            180                 185                 190         


Ile Glu Lys Asp Asn Lys Asp Phe Tyr Leu Arg Trp Tyr Asn Gly Leu 
        195                 200                 205             


Arg Phe Leu Phe Asn Phe Gly Lys Asp Arg Ser Asn Asn Arg Leu Ile 
    210                 215                 220                 


Val Glu Arg Cys Leu Lys Met Asp Ala Asp Tyr Asp Gly Glu Tyr Lys 
225                 230                 235                 240 


Leu Cys Asn Ser Ser Ile Gln Ile Ala Lys Arg Glu Gly Lys Thr Lys 
                245                 250                 255     


Leu Phe Leu Leu Leu Val Val Lys Ile Pro Gln Glu His Val Glu Leu 
            260                 265                 270         


Asn Lys Lys Val Val Val Gly Val Asp Leu Gly Ile Asn Val Pro Ala 
        275                 280                 285             


Tyr Val Ala Thr Asn Ile Thr Glu Glu Arg Lys Ala Ile Gly Asp Arg 
    290                 295                 300                 


Glu His Phe Leu Asn Ser Arg Met Ala Phe Gln Arg Arg Tyr Lys Ser 
305                 310                 315                 320 


Leu Gln Arg Leu Arg Gly Thr Ala Gly Gly Lys Gly Arg Ala Lys Lys 
                325                 330                 335     


Leu Glu Pro Leu Glu Arg Leu Arg Lys Ala Glu His Asn Trp Val His 
            340                 345                 350         


Thr Gln Asn His Leu Phe Ser Arg Glu Val Val Asp Phe Ala Val Lys 
        355                 360                 365             


Ser His Ala Ala Thr Ile His Met Glu Asp Leu Ser Gly Phe Gly Lys 
    370                 375                 380                 


Asp Asn Asp Gly Asn Ala Asp Glu Arg Lys Glu Phe Val Leu Arg Asn 
385                 390                 395                 400 


Trp Ser Tyr Tyr Glu Leu Gln Asn Met Ile Ala Tyr Lys Ala Ala Lys 
                405                 410                 415     


Tyr Gly Ile Lys Val Glu Lys Ile His Pro Ala Tyr Thr Ser Lys Thr 
            420                 425                 430         


Cys Ser Trp Cys Gly Gln Leu Gly Phe Arg Glu Gly Val Thr Phe Ile 
        435                 440                 445             


Cys Glu Asn Pro Glu Cys Lys Gln Cys Gly Glu Lys Val His Ala Asp 
    450                 455                 460                 


Tyr Asn Ala Ala Arg Asn Ile Ala Asn Ser Lys Asp Ile Ile Lys Lys 
465                 470                 475                 480 


Asn Glu Gly Ser Asp Gly Gly Ser Gly Gly Gly Ser Thr Ser Arg Asp 
                485                 490                 495     


His Met Val Leu His Glu Tyr Val Asn Ala Ala Gly Ile Thr 
            500                 505                 510 


<210>  815
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full uncleaved sequence of T2A tagged CasM. 19952

<400>  815

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Met Pro Thr Ile Thr Arg Lys Ile 
        35                  40                  45              


Glu Leu Thr Leu Leu Thr Glu Gly Leu Ser Glu Glu Gln Arg Lys Glu 
    50                  55                  60                  


Gln Trp Gly Leu Leu Tyr His Ile Asn Asp Asn Leu Tyr Lys Ala Ala 
65                  70                  75                  80  


Asn Asn Ile Ser Ser Lys Leu Tyr Leu Asp Asp His Val Ser Ser Met 
                85                  90                  95      


Val Arg Met Lys His Ala Glu Tyr Leu Ser Leu Leu Lys Glu Leu Ala 
            100                 105                 110         


Arg Ala Glu Lys Gln Lys Thr Pro Asp Ala Asp Ala Ile Ala Glu Leu 
        115                 120                 125             


Arg Lys Lys Val Ala Ala Ala Glu Lys Glu Met Thr Asp Gln Glu His 
    130                 135                 140                 


Ala Ile Cys Lys Tyr Ala Thr Glu Met Ser Thr Gln Ser Leu Ser Tyr 
145                 150                 155                 160 


Arg Phe Ala Thr Glu Leu Glu Thr Asn Ile Phe Ala Lys Ile Leu Asp 
                165                 170                 175     


Cys Leu Lys Gln Gly Val Phe Ala Thr Phe Asn Ser Asp Ala Arg Asp 
            180                 185                 190         


Val Lys Arg Gly Glu Arg Ala Ile Arg Asn Tyr Lys Lys Gly Met Pro 
        195                 200                 205             


Ile Pro Phe Ala Trp Asp Lys Ser Leu Arg Ile Glu Lys Asp Asn Lys 
    210                 215                 220                 


Asp Phe Tyr Leu Arg Trp Tyr Asn Gly Leu Arg Phe Leu Phe Asn Phe 
225                 230                 235                 240 


Gly Lys Asp Arg Ser Asn Asn Arg Leu Ile Val Glu Arg Cys Leu Lys 
                245                 250                 255     


Met Asp Ala Asp Tyr Asp Gly Glu Tyr Lys Leu Cys Asn Ser Ser Ile 
            260                 265                 270         


Gln Ile Ala Lys Arg Glu Gly Lys Thr Lys Leu Phe Leu Leu Leu Val 
        275                 280                 285             


Val Lys Ile Pro Gln Glu His Val Glu Leu Asn Lys Lys Val Val Val 
    290                 295                 300                 


Gly Val Asp Leu Gly Ile Asn Val Pro Ala Tyr Val Ala Thr Asn Ile 
305                 310                 315                 320 


Thr Glu Glu Arg Lys Ala Ile Gly Asp Arg Glu His Phe Leu Asn Ser 
                325                 330                 335     


Arg Met Ala Phe Gln Arg Arg Tyr Lys Ser Leu Gln Arg Leu Arg Gly 
            340                 345                 350         


Thr Ala Gly Gly Lys Gly Arg Ala Lys Lys Leu Glu Pro Leu Glu Arg 
        355                 360                 365             


Leu Arg Lys Ala Glu His Asn Trp Val His Thr Gln Asn His Leu Phe 
    370                 375                 380                 


Ser Arg Glu Val Val Asp Phe Ala Val Lys Ser His Ala Ala Thr Ile 
385                 390                 395                 400 


His Met Glu Asp Leu Ser Gly Phe Gly Lys Asp Asn Asp Gly Asn Ala 
                405                 410                 415     


Asp Glu Arg Lys Glu Phe Val Leu Arg Asn Trp Ser Tyr Tyr Glu Leu 
            420                 425                 430         


Gln Asn Met Ile Ala Tyr Lys Ala Ala Lys Tyr Gly Ile Lys Val Glu 
        435                 440                 445             


Lys Ile His Pro Ala Tyr Thr Ser Lys Thr Cys Ser Trp Cys Gly Gln 
    450                 455                 460                 


Leu Gly Phe Arg Glu Gly Val Thr Phe Ile Cys Glu Asn Pro Glu Cys 
465                 470                 475                 480 


Lys Gln Cys Gly Glu Lys Val His Ala Asp Tyr Asn Ala Ala Arg Asn 
                485                 490                 495     


Ile Ala Asn Ser Lys Asp Ile Ile Lys Lys Asn Glu Lys Arg Pro Ala 
            500                 505                 510         


Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Glu Phe Gly Ser 
        515                 520                 525             


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
    530                 535                 540                 


Pro Gly Pro 
545         


<210>  816
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleaved sequence of T2A tagged CasM. 19952

<400>  816

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Met Pro Thr Ile Thr Arg Lys Ile 
        35                  40                  45              


Glu Leu Thr Leu Leu Thr Glu Gly Leu Ser Glu Glu Gln Arg Lys Glu 
    50                  55                  60                  


Gln Trp Gly Leu Leu Tyr His Ile Asn Asp Asn Leu Tyr Lys Ala Ala 
65                  70                  75                  80  


Asn Asn Ile Ser Ser Lys Leu Tyr Leu Asp Asp His Val Ser Ser Met 
                85                  90                  95      


Val Arg Met Lys His Ala Glu Tyr Leu Ser Leu Leu Lys Glu Leu Ala 
            100                 105                 110         


Arg Ala Glu Lys Gln Lys Thr Pro Asp Ala Asp Ala Ile Ala Glu Leu 
        115                 120                 125             


Arg Lys Lys Val Ala Ala Ala Glu Lys Glu Met Thr Asp Gln Glu His 
    130                 135                 140                 


Ala Ile Cys Lys Tyr Ala Thr Glu Met Ser Thr Gln Ser Leu Ser Tyr 
145                 150                 155                 160 


Arg Phe Ala Thr Glu Leu Glu Thr Asn Ile Phe Ala Lys Ile Leu Asp 
                165                 170                 175     


Cys Leu Lys Gln Gly Val Phe Ala Thr Phe Asn Ser Asp Ala Arg Asp 
            180                 185                 190         


Val Lys Arg Gly Glu Arg Ala Ile Arg Asn Tyr Lys Lys Gly Met Pro 
        195                 200                 205             


Ile Pro Phe Ala Trp Asp Lys Ser Leu Arg Ile Glu Lys Asp Asn Lys 
    210                 215                 220                 


Asp Phe Tyr Leu Arg Trp Tyr Asn Gly Leu Arg Phe Leu Phe Asn Phe 
225                 230                 235                 240 


Gly Lys Asp Arg Ser Asn Asn Arg Leu Ile Val Glu Arg Cys Leu Lys 
                245                 250                 255     


Met Asp Ala Asp Tyr Asp Gly Glu Tyr Lys Leu Cys Asn Ser Ser Ile 
            260                 265                 270         


Gln Ile Ala Lys Arg Glu Gly Lys Thr Lys Leu Phe Leu Leu Leu Val 
        275                 280                 285             


Val Lys Ile Pro Gln Glu His Val Glu Leu Asn Lys Lys Val Val Val 
    290                 295                 300                 


Gly Val Asp Leu Gly Ile Asn Val Pro Ala Tyr Val Ala Thr Asn Ile 
305                 310                 315                 320 


Thr Glu Glu Arg Lys Ala Ile Gly Asp Arg Glu His Phe Leu Asn Ser 
                325                 330                 335     


Arg Met Ala Phe Gln Arg Arg Tyr Lys Ser Leu Gln Arg Leu Arg Gly 
            340                 345                 350         


Thr Ala Gly Gly Lys Gly Arg Ala Lys Lys Leu Glu Pro Leu Glu Arg 
        355                 360                 365             


Leu Arg Lys Ala Glu His Asn Trp Val His Thr Gln Asn His Leu Phe 
    370                 375                 380                 


Ser Arg Glu Val Val Asp Phe Ala Val Lys Ser His Ala Ala Thr Ile 
385                 390                 395                 400 


His Met Glu Asp Leu Ser Gly Phe Gly Lys Asp Asn Asp Gly Asn Ala 
                405                 410                 415     


Asp Glu Arg Lys Glu Phe Val Leu Arg Asn Trp Ser Tyr Tyr Glu Leu 
            420                 425                 430         


Gln Asn Met Ile Ala Tyr Lys Ala Ala Lys Tyr Gly Ile Lys Val Glu 
        435                 440                 445             


Lys Ile His Pro Ala Tyr Thr Ser Lys Thr Cys Ser Trp Cys Gly Gln 
    450                 455                 460                 


Leu Gly Phe Arg Glu Gly Val Thr Phe Ile Cys Glu Asn Pro Glu Cys 
465                 470                 475                 480 


Lys Gln Cys Gly Glu Lys Val His Ala Asp Tyr Asn Ala Ala Arg Asn 
                485                 490                 495     


Ile Ala Asn Ser Lys Asp Ile Ile Lys Lys Asn Glu Lys Arg Pro Ala 
            500                 505                 510         


Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Glu Phe Gly Ser 
        515                 520                 525             


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
    530                 535                 540                 


Pro Gly 
545     


<210>  817
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminus sequence of TEV-cleavable MBP tag before CasM. 19952

<400>  817

Met Lys Ser Ser His His His His His His His His His His Gly Ser 
1               5                   10                  15      


Ser Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp 
            20                  25                  30          


Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp 
        35                  40                  45              


Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys 
    50                  55                  60                  


Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp 
65                  70                  75                  80  


Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu 
                85                  90                  95      


Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp 
            100                 105                 110         


Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val 
        115                 120                 125             


Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro 
    130                 135                 140                 


Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys 
145                 150                 155                 160 


Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp 
                165                 170                 175     


Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly 
            180                 185                 190         


Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala 
        195                 200                 205             


Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala 
    210                 215                 220                 


Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr 
225                 230                 235                 240 


Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser 
                245                 250                 255     


Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro 
            260                 265                 270         


Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser 
        275                 280                 285             


Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr 
    290                 295                 300                 


Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val 
305                 310                 315                 320 


Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala 
                325                 330                 335     


Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro 
            340                 345                 350         


Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala 
        355                 360                 365             


Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr 
    370                 375                 380                 


Asn Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly 
385                 390                 395                 400 


Ile Glu Glu Asn Leu Tyr Phe Gln Ser Asn Ala 
                405                 410     


<210>  818
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10X His tag

<400>  818

His His His His His His His His His His 
1               5                   10  


<210>  819
<211>  367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MBP tag

<400>  819

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr 
        355                 360                 365         


<210>  820
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminus His6 tag plus linker before CasM. 19952

<400>  820

Met Lys Ser Ser His His His His His His His Gly Ser Ser 
1               5                   10                  


<210>  821
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminus Linker-GFP11 tag after CasM. 19952

<400>  821

Gly Ser Asp Gly Gly Ser Gly Gly Gly Ser Thr Ser Arg Asp His Met 
1               5                   10                  15      


Val Leu His Glu Tyr Val Asn Ala Ala Gly Ile Thr 
            20                  25              


<210>  822
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N terminus of T2A tagged effector protein

<400>  822

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala 
        35                  40  


<210>  823
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3x FLAG tag of N terminus of T2A tagged effector protein

<400>  823

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys 
            20              


<210>  824
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C terminus of T2A tagged effector protein

<400>  824

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Glu Phe Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
            20                  25                  30          


Val Glu Glu Asn Pro Gly Pro 
        35                  


<210>  825
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS (nucleoplasmin) of C terminus of T2A tagged effector protein

<400>  825

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  826
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A self-cleaving peptide sequence

<400>  826

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  827
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  827
cguugcagcu cgcacguugg cacugguuga agg                                    33


<210>  828
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  828
cguugcagcu cgcacguugg cacuggguug aagg                                   34


<210>  829
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  829
uuggcacugg uugaagg                                                      17


<210>  830
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  830
cacugguuga agg                                                          13


<210>  831
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  831
guugcaacuc acgcgcguau guggcuugaa gg                                     32


<210>  832
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  832
guugcaauuc auaucuccgg guggauugaa gg                                     32


<210>  833
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  833
agcguguggc uugaagg                                                      17


<210>  834
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  834
uguggcuuga agg                                                          13


<210>  835
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  835
guugcagcgu gcgcgagcgu guggcuugaa gg                                     32


<210>  836
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  836
guugcaacuc gcacgugaau gcgacuugaa gg                                     32


<210>  837
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  837
ugaaugcgac uugaagg                                                      17


<210>  838
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  838
gaugcaacuc guguguaugu gcgaguugaa gg                                     32


<210>  839
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  839
gacgcaacuc gcgcgcgggc auguauugag gg                                     32


<210>  840
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  840
gaugcaucug acacagcugg gugaguugaa gg                                     32


<210>  841
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  841
gcugggugag uugaagg                                                      17


<210>  842
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  842
guugcaacac auguaugugg gugaguugaa gg                                     32


<210>  843
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  843
guugcaauuu guauacgagu gugacuugaa gg                                     32


<210>  844
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  844
gcugcaacac gcgcggguac gcggguugaa gg                                     32


<210>  845
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  845
guugcaacuc gcacguuggc acugauugaa gg                                     32


<210>  846
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  846
gcuguagccc ugcucaaauu guagggcgca ugcagg                                 36


<210>  847
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  847
guuguagucg accugaaucu guggggugcu uacagg                                 36


<210>  848
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  848
guuguagucg accugaaucu guggggugcu uacagg                                 36


<210>  849
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  849
gguguaugua accgcaauuu gaagggugca uacagg                                 36


<210>  850
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  850
guuggaaucg accuuaauuu gaggugugcu uacagg                                 36


<210>  851
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  851
gcugaaagag cagagaauuu guugugugca uacagg                                 36


<210>  852
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  852
guuggagucg gcuugaaucu gcggggugcu uacagg                                 36


<210>  853
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  853
guuguaagag acccgaauuu uagcugugua uacagg                                 36


<210>  854
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  854
guugugaaug caggcauuuu ugaugguaaa uccaac                                 36


<210>  855
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  855
acugucagac aaugcaaaau gugugguaca uccaac                                 36


<210>  856
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  856
ugguacaucc                                                              10


<210>  857
<211>  65
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  857
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuacau       60

ccaac                                                                   65


<210>  858
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  858
ugguacaucc aacucuaggc gcc                                               23


<210>  859
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  859
aaugguacau ccaac                                                        15


<210>  860
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  860
ugguacaucc aacucuaggc                                                   20


<210>  861
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  861
ugguacaucc aacucuaggc gc                                                22


<210>  862
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  862
ugguacaucc aacucuaggc g                                                 21


<210>  863
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  863
ugguacaucc aacucuaggc g                                                 21


<210>  864
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  864
ugguacaucc aacucuaggc g                                                 21


<210>  865
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  865
ugguacaucc aacucu                                                       16


<210>  866
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  866
ugguacaucc aacuc                                                        15


<210>  867
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  867
ugguacaucc aacu                                                         14


<210>  868
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  868
ugguacaucc aacucuag                                                     18


<210>  869
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  869
ugguauaucc aac                                                          13


<210>  870
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  870
ugguacaucc aacucua                                                      17


<210>  871
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  871
augguacauc caac                                                         14


<210>  872
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  872
ugguacaucc aa                                                           12


<210>  873
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  873
ugguacaucc a                                                            11


<210>  874
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  874
gcugucagua guaguaaaaa uggggguaca uccaac                                 36


<210>  875
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  875
acugucagua caugcaaaaa ugaggguaca uccaac                                 36


<210>  876
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  876
acugucagac aaugcaaaau gagugguaca uccaac                                 36


<210>  877
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  877
gcuguuagaa cauacaaaau gaaagguaca uccaac                                 36


<210>  878
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  878
gcugcauguc auggcaaaag gaaagguaca uccaac                                 36


<210>  879
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  879
gcugucagac accuaaaaaa ugaggguaca uccaac                                 36


<210>  880
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  880
gcugugaguc acaguaaaaa ugaagguaua uccaac                                 36


<210>  881
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  881
gauguauaug cuaugauuuu guaugguaca uccaac                                 36


<210>  882
<211>  37
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  882
guugcagaac ccgaauagac gaaugaagga augcaac                                37


<210>  883
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  883
guugagcucu gcauuacgca gaugaaugac gag                                    33


<210>  884
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  884
gauauaucuu guaugcauau guagguugug ag                                     32


<210>  885
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  885
gauauaucuu guaugcauau guagguugug ag                                     32


<210>  886
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  886
gaugcaacuu agaugcauau guaaguugug ag                                     32


<210>  887
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  887
guugcaauga acguaugugc augaggugug ag                                     32


<210>  888
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  888
guugcaauuc guaugcgcag guaaguuucg ag                                     32


<210>  889
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  889
ugugcaugag gugugag                                                      17


<210>  890
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  890
guugcaaucu gcguacaggc guaagaugug ag                                     32


<210>  891
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  891
caggcguaag augugag                                                      17


<210>  892
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  892
gaucauaucu gcuuguaugg guaugcugcg ag                                     32


<210>  893
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  893
uauggguaug cugcgag                                                      17


<210>  894
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  894
guugcaacuu acgcauaggu guaaaauacg ag                                     32


<210>  895
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  895
gauuauaucu gcuuguaugg guauacugcg ag                                     32


<210>  896
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  896
ucagcucaca accuacauau gcauacaaga uauaucgu                               38


<210>  897
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  897
cauauguagg uugugag                                                      17


<210>  898
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  898
uguagguugu gag                                                          13


<210>  899
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  899
caugaggugu gag                                                          13


<210>  900
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  900
ugcgguguaa uucgagg                                                      17


<210>  901
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  901
gaugugaacg accuuuuuuu gcggugugcu ucgagg                                 36


<210>  902
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  902
gguggauauc aucuuaaaaa gugagguaca uccaac                                 36


<210>  903
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or u

<400>  903
crrnaggugu gaacgaccuu uuuuugcggu guaauucgag g                           41


<210>  904
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  904
uugcggugua cuucgagg                                                     18


<210>  905
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  905
agaagaagga uugggac                                                      17


<210>  906
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  906
aaugugaacg accuucuuuu gcgguguacu ucgagg                                 36


<210>  907
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  907
aagguugaua cagc                                                         14


<210>  908
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  908
gcuguaaguc auggaaaaau ggugaguaca uccaac                                 36


<210>  909
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  909
auggugagua cauccaac                                                     18


<210>  910
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  910
gagcacaucc aac                                                          13


<210>  911
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  911
ggguacaucc aac                                                          13


<210>  912
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  912
guugcguuug cccgugauuu cgggugugua uacagg                                 36


<210>  913
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  913
agguauaucc aac                                                          13


<210>  914
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  914
ggcguauguc uaccugaaaa agaagguaua uccaac                                 36


<210>  915
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  915
ggcuacauac agc                                                          13


<210>  916
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  916
gguguaugug caccauauau guaggugaca uacagc                                 36


<210>  917
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  917
aaaacaagga uugaaac                                                      17


<210>  918
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  918
gaugugaacg accuuuuuuu gcgguguacu ucgagg                                 36


<210>  919
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  919
guguacuucg agg                                                          13


<210>  920
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  920
gauguaaauc aucuauaaaa gaaagguaca uccaac                                 36


<210>  921
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  921
gguacaucca ac                                                           12


<210>  922
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  922
cguacgugga uugaaac                                                      17


<210>  923
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  923
gcugcacugc accgcccauu gauggugugc ucuagg                                 36


<210>  924
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  924
auuguaggcg accuuuuuuu gcgauguagu ucgagg                                 36


<210>  925
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  925
auguaguucg agg                                                          13


<210>  926
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  926
aguguaugau uaccuguagu augagguaca uccaac                                 36


<210>  927
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  927
gcugcaagag cuccuaauuu gaggggugca uacagg                                 36


<210>  928
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA guide nucleic acid

<400>  928
gauaguuuua acuuccauuu gaaauguaaa ugcaac                                 36


<210>  929
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  929
auguaaaugc aac                                                          13


<210>  930

<400>  930
000

<210>  931

<400>  931
000

<210>  932
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  932
uggggcaguu gguugcccuu agccugaggc auuuauugca cucgggaagu accauuucuc       60

agaaauggua uauccaac                                                     78


<210>  933
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  933
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaga aaaac            55


<210>  934
<211>  65
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  934
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccgaaaau       60

ccaac                                                                   65


<210>  935
<211>  79
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  935
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaaaggu acauccaac                                                    79


<210>  936
<211>  71
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  936
auggggcagu ugguugcccu uagccugagg cauuuaaugc acucgggaag uaccuuuucu       60

cagaaaccaa c                                                            71


<210>  937
<211>  136
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA guide nucleic acid

<400>  937
uuauuagaaa ugaaauauuu ucuaaugggg uuguuggaaa gagcuuuuac ugaaauuugu       60

aaaggugccc ugaacuugag aauugaaaaa uuacucgagg aaaugguaca uccaacuauu      120

aaauacucgu auugcu                                                      136


<210>  938
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA guide nucleic acid

<400>  938
cgauuccucc cuacaguagu uagguauagc cgaaagguag agacuaaauc uguaguugga       60

gugggccgcu ugcaucggcc uaaaguugag aagugucaga cucugauaac ccucaacgac      120

gauauucuuu auuucgguuc aaaguucugc acaaaacagg ugaguccuua uaaaccggug      180

ugcagaacg                                                              189


<210>  939
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA guide nucleic acid

<400>  939
cgauuccucc cuacaguagu uagguauagc cgaaagguag agacuaaauc uguaguugga       60

gugggccgcu ugcaucggcc uaaaguugag aagugucaga cucugauaac ccucaacgac      120

gauauucuuu auuucgguuc aaaguucugc acaaaacagg ugaguccuua uaaaccggug      180

ugcagaacg                                                              189


<210>  940
<211>  189
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA guide nucleic acid

<400>  940
cgauuccucc cuacaguagu uagguauagc cgaaagguag agacuaaauc uguaguugga       60

gugggccgcu ugcaucggcc uaaaguugag aagugucaga cucugauaac ccucaacgac      120

gauauucuuu auuucgguuc aaaguucugc acaaaacagg ugaguccuua uaaaccggug      180

ugcagaacg                                                              189


<210>  941
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  guide nucleic acid

<400>  941
augaauagga uucguccuau ggggcaguug guugcccuua gccugaggca uuuauugcac       60

ucgggaagua ccauuucuca gaaaugguac auccaac                                97


<210>  942
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  guide nucleic acid

<400>  942
ugguacaucc                                                              10


<210>  943
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  guide nucleic acid

<400>  943
ugguauaucc                                                              10


