                         SEQUENCE LISTING

<110>  ALPHA-5 INTEGRIN, LLC
 
<120>  ALPHA 5 BETA 1 INTEGRIN BINDING AGENTS AND USES THEREOF

<130>  14700-001-228

<140>
<141>

<150>  US 63/187,371
<151>  2021-05-11

<160>  154   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10 VH CDR1 (Exemplary, AbM)

<400>  1

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10 VH CDR2 (Exemplary, Kabat)

<400>  2

Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Thr Leu Lys Ser 
1               5                   10                  15      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10 VH CDR3 (Exemplary, Kabat, AbM)

<400>  3

His Tyr Asp Tyr Asp Gly Asp Trp Phe Ala Tyr 
1               5                   10      


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08 VL CDR1 (Exemplary, Kabat, AbM)

<400>  4

Thr Ala Ser Ser Arg Val Ser Ser Asn Ser Leu His 
1               5                   10          


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-3B06, A2-5D10, C-14D12 VL CDR2 (Exemplary, Kabat, 
       AbM)

<400>  5

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-3B06 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  6

His Gln Tyr Leu Arg Ser Pro Pro Thr 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10 VH CDR1 (IMGT)

<400>  7

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-3B06, A2-5D10, C-14D12 VH CDR2 (IMGT)

<400>  8

Ile Trp Ser Asp Gly Ser Thr 
1               5           


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10 VH CDR3 (IMGT)

<400>  9

Ala Arg His Tyr Asp Tyr Asp Gly Asp Trp Phe Ala Tyr 
1               5                   10              


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08 VL CDR1 (IMGT)

<400>  10

Ser Arg Val Ser Ser Asn Ser 
1               5           


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-3B06, A2-5D10, C-14D12 VL CDR2 (IMGT, Chothia)

<400>  11

Ser Thr Ser 
1           


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10 VH CDR1 (Kabat)

<400>  12

Ser Tyr Gly Val His 
1               5   


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10 VH CDR1 (Chothia)

<400>  13

Gly Phe Ser Leu Thr Ser Tyr 
1               5           


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-3B06, A2-5D10, C-14D12 VH CDR2 (Chothia)

<400>  14

Ser Asp Gly 
1           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10 VH CDR3 (Chothia)

<400>  15

Tyr Asp Tyr Asp Gly Asp Trp Phe Ala 
1               5                   


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08 VL CDR1 (Chothia)

<400>  16

Ser Ser Arg Val Ser Ser Asn Ser 
1               5               


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-3B06 VL CDR3 (Chothia)

<400>  17

Tyr Leu Arg Ser Pro Pro 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10 VH CDR1 (Contact)

<400>  18

Thr Ser Tyr Gly Val His 
1               5       


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-3B06, A2-5D10, C-14D12 VH CDR2 (Contact)

<400>  19

Trp Leu Val Val Ile Trp Ser Asp Gly Ser Thr Thr 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10 VH CDR3 (Contact)

<400>  20

Ala Arg His Tyr Asp Tyr Asp Gly Asp Trp Phe Ala 
1               5                   10          


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08 VL CDR1 (Contact)

<400>  21

Ser Ser Asn Ser Leu His Trp Tyr 
1               5               


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-5D10, C-14D12 VL CDR2 (Contact)

<400>  22

Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala 
1               5                   10  


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-3B06 VL CDR3 (Contact)

<400>  23

His Gln Tyr Leu Arg Ser Pro Pro 
1               5               


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08, A2-3B06, A2-5D10, C-14D12 VH CDR2 (AbM)

<400>  24

Val Ile Trp Ser Asp Gly Ser Thr Thr 
1               5                   


<210>  25
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08 VH Sequence

<400>  25

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Thr Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Asp Tyr Asp Gly Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  26
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08 VL Sequence

<400>  26

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Arg Val Ser Ser Asn 
            20                  25                  30          


Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VH CDR1 (Exemplary, AbM)

<400>  27

Gly Phe Ser Leu Thr Thr Tyr Gly Val His 
1               5                   10  


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06, C-14D12 VH CDR2 (Exemplary, Kabat)

<400>  28

Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VH CDR3 (Exemplary, Kabat, AbM)

<400>  29

His Gly Gly Leu Leu Arg Arg Asp Ala Met Asp Tyr 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VL CDR1 (Exemplary, Kabat, AbM)

<400>  30

Thr Ala Ser Ser Ser Val Ser Ser Asn Ser Phe His 
1               5                   10          


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VH CDR1 (IMGT)

<400>  31

Gly Phe Ser Leu Thr Thr Tyr Gly 
1               5               


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VH CDR3 (IMGT)

<400>  32

Val Arg His Gly Gly Leu Leu Arg Arg Asp Ala Met Asp Tyr 
1               5                   10                  


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VL CDR1 (IMGT)

<400>  33

Ser Ser Val Ser Ser Asn Ser 
1               5           


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VH CDR1 (Kabat)

<400>  34

Thr Tyr Gly Val His 
1               5   


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VH CDR1 (Chothia)

<400>  35

Gly Phe Ser Leu Thr Thr Tyr 
1               5           


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VH CDR3 (Chothia)

<400>  36

Gly Gly Leu Leu Arg Arg Asp Ala Met Asp 
1               5                   10  


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VL CDR1 (Chothia)

<400>  37

Ser Ser Ser Val Ser Ser Asn Ser 
1               5               


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VH CDR1 (Contact)

<400>  38

Thr Thr Tyr Gly Val His 
1               5       


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VH CDR3 (Contact)

<400>  39

Val Arg His Gly Gly Leu Leu Arg Arg Asp Ala Met Asp 
1               5                   10              


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VL CDR1 (Contact)

<400>  40

Ser Ser Asn Ser Phe His Trp Tyr 
1               5               


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VL CDR2 (Contact)

<400>  41

Leu Trp Leu Tyr Ser Thr Ser Asn Leu Ala 
1               5                   10  


<210>  42
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VH Sequence

<400>  42

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Asn Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Val 
                85                  90                  95      


Arg His Gly Gly Leu Leu Arg Arg Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  43
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-3B06 VL Sequence

<400>  43

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Leu Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-5D10 VL CDR1 (Exemplary, Kabat, AbM)

<400>  44

Thr Ala Ser Ser Ser Val Ser Ser Arg Cys Leu His 
1               5                   10          


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-5D10 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  45

His Gln Tyr Tyr Arg Ser Pro Pro Thr 
1               5                   


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-5D10 VL CDR1 (IMGT)

<400>  46

Ser Ser Val Ser Ser Arg Cys 
1               5           


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-5D10 VL CDR1 (Chothia)

<400>  47

Ser Ser Ser Val Ser Ser Arg Cys 
1               5               


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-5D10 VL CDR3 (Chothia)

<400>  48

Tyr Tyr Arg Ser Pro Pro 
1               5       


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-5D10 VL CDR1 (Contact)

<400>  49

Ser Ser Arg Cys Leu His Trp Tyr 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-5D10 VL CDR3 (Contact)

<400>  50

His Gln Tyr Tyr Arg Ser Pro Pro 
1               5               


<210>  51
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-5D10 VH Sequence

<400>  51

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Thr Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Asp Tyr Asp Gly Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  52
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-5D10 VL Sequence

<400>  52

Gln Ile Leu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Arg 
            20                  25                  30          


Cys Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Arg 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VH CDR1 (Exemplary, AbM)

<400>  53

Gly Tyr Thr Phe Thr Ile Tyr Trp Ile Asn 
1               5                   10  


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VH CDR2 (Exemplary, Kabat)

<400>  54

Lys Ile Tyr Pro Gly Ser Ile Ser Thr Asp Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VH CDR3 (Exemplary, Kabat, AbM)

<400>  55

Thr Gly Thr Gly Gly Leu Ala Tyr 
1               5               


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VL CDR1 (Exemplary, Kabat, AbM)

<400>  56

Arg Ala Ser Ser Ser Val Asn Tyr Met Tyr 
1               5                   10  


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VL CDR2 (Exemplary, Kabat, AbM)

<400>  57

Phe Thr Ser Ser Leu Ala Pro 
1               5           


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  58

Gln Gln Phe Thr Thr Ser Pro Phe Thr 
1               5                   


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VH CDR1 (IMGT)

<400>  59

Gly Tyr Thr Phe Thr Ile Tyr Trp 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VH CDR2 (IMGT)

<400>  60

Ile Tyr Pro Gly Ser Ile Ser Thr 
1               5               


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VH CDR3 (IMGT)

<400>  61

Ala Ile Thr Gly Thr Gly Gly Leu Ala Tyr 
1               5                   10  


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VL CDR1 (IMGT)

<400>  62

Ser Ser Val Asn Tyr 
1               5   


<210>  63
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VL CDR2 (IMGT, Chothia)

<400>  63

Phe Thr Ser 
1           


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VH CDR1 (Kabat)

<400>  64

Ile Tyr Trp Ile Asn 
1               5   


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VH CDR1 (Chothia)

<400>  65

Gly Tyr Thr Phe Thr Ile Tyr 
1               5           


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VH CDR2 (Chothia)

<400>  66

Pro Gly Ser Ile 
1               


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VH CDR3 (Chothia)

<400>  67

Gly Thr Gly Gly Leu Ala 
1               5       


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VL CDR1 (Chothia)

<400>  68

Ser Ser Ser Val Asn Tyr 
1               5       


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VL CDR3 (Chothia)

<400>  69

Phe Thr Thr Ser Pro Phe 
1               5       


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VH CDR1 (Contact)

<400>  70

Thr Ile Tyr Trp Ile Asn 
1               5       


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VH CDR2 (Contact)

<400>  71

Trp Ile Gly Lys Ile Tyr Pro Gly Ser Ile Ser Thr Asp 
1               5                   10              


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VH CDR3 (Contact)

<400>  72

Ala Ile Thr Gly Thr Gly Gly Leu Ala 
1               5                   


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VL CDR1 (Contact)

<400>  73

Asn Tyr Met Tyr Trp Tyr 
1               5       


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05, A2-7F01 VL CDR2 (Contact)

<400>  74

Leu Trp Ile Tyr Phe Thr Ser Ser Leu Ala 
1               5                   10  


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VL CDR3 (Contact)

<400>  75

Gln Gln Phe Thr Thr Ser Pro Phe 
1               5               


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VH CDR2 (AbM)

<400>  76

Lys Ile Tyr Pro Gly Ser Ile Ser Thr Asp 
1               5                   10  


<210>  77
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VH Sequence

<400>  77

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Tyr Pro Gly Ser Ile Ser Thr Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Thr Gly Thr Gly Gly Leu Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  78
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7A05 VL Sequence

<400>  78

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Phe Thr Ser Ser Leu Ala Pro Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Gly Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Thr Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VH CDR2 (Exemplary, Kabat)

<400>  79

Asn Ile Tyr Pro Gly Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VH CDR3 (Exemplary, Kabat, AbM)

<400>  80

Thr Gly Thr Gly Gly Phe Ala Tyr 
1               5               


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  81

Gln Gln Leu Thr Gly Ser Pro Phe Thr 
1               5                   


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VH CDR2 (IMGT)

<400>  82

Ile Tyr Pro Gly Ser Ser Ser Thr 
1               5               


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VH CDR3 (IMGT)

<400>  83

Ala Ile Thr Gly Thr Gly Gly Phe Ala Tyr 
1               5                   10  


<210>  84
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VH CDR2 (Chothia)

<400>  84

Pro Gly Ser Ser 
1               


<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VH CDR3 (Chothia)

<400>  85

Gly Thr Gly Gly Phe Ala 
1               5       


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VL CDR3 (Chothia)

<400>  86

Leu Thr Gly Ser Pro Phe 
1               5       


<210>  87
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VH CDR2 (Contact)

<400>  87

Trp Ile Gly Asn Ile Tyr Pro Gly Ser Ser Ser Thr Asn 
1               5                   10              


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VH CDR3 (Contact)

<400>  88

Ala Ile Thr Gly Thr Gly Gly Phe Ala 
1               5                   


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VL CDR3 (Contact)

<400>  89

Gln Gln Leu Thr Gly Ser Pro Phe 
1               5               


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VH CDR2 (AbM)

<400>  90

Asn Ile Tyr Pro Gly Ser Ser Ser Thr Asn 
1               5                   10  


<210>  91
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VH Sequence

<400>  91

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Ser Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Thr Gly Thr Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  92
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2-7F01 VL Sequence

<400>  92

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Asp Ala Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Phe Thr Ser Ser Leu Ala Pro Gly Val Pro Thr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Phe Ser Leu Thr Ile Ser Ser Met Glu Gly Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Leu Thr Gly Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VH CDR1 (Exemplary, AbM)

<400>  93

Gly Phe Ser Leu Thr Asp Tyr Gly Val His 
1               5                   10  


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VH CDR3 (Exemplary, Kabat, AbM)

<400>  94

His Ala Pro Ser Phe Ile Arg Tyr Gly Ser Arg Tyr Asp Ala Leu Asp 
1               5                   10                  15      


Tyr 
    


<210>  95
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VL CDR1 (Exemplary, Kabat, AbM)

<400>  95

Thr Ala Ser Ser Ser Val Thr Ser Ser Phe Leu His 
1               5                   10          


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  96

His Gln Tyr His Arg Ser Pro Pro Thr 
1               5                   


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VH CDR1 (IMGT)

<400>  97

Gly Phe Ser Leu Thr Asp Tyr Gly 
1               5               


<210>  98
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VH CDR3 (IMGT)

<400>  98

Ala Arg His Ala Pro Ser Phe Ile Arg Tyr Gly Ser Arg Tyr Asp Ala 
1               5                   10                  15      


Leu Asp Tyr 
            


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VL CDR1 (IMGT)

<400>  99

Ser Ser Val Thr Ser Ser Phe 
1               5           


<210>  100
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VH CDR1 (Kabat)

<400>  100

Asp Tyr Gly Val His 
1               5   


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VH CDR1 (Chothia)

<400>  101

Gly Phe Ser Leu Thr Asp Tyr 
1               5           


<210>  102
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VH CDR3 (Chothia)

<400>  102

Ala Pro Ser Phe Ile Arg Tyr Gly Ser Arg Tyr Asp Ala Leu Asp 
1               5                   10                  15  


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VL CDR1 (Chothia)

<400>  103

Ser Ser Ser Val Thr Ser Ser Phe 
1               5               


<210>  104
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VL CDR3 (Chothia)

<400>  104

Tyr His Arg Ser Pro Pro 
1               5       


<210>  105
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VH CDR1 (Contact)

<400>  105

Thr Asp Tyr Gly Val His 
1               5       


<210>  106
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VH CDR3 (Contact)

<400>  106

Ala Arg His Ala Pro Ser Phe Ile Arg Tyr Gly Ser Arg Tyr Asp Ala 
1               5                   10                  15      


Leu Asp 
        


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VL CDR1 (Contact)

<400>  107

Thr Ser Ser Phe Leu His Trp Tyr 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VL CDR3 (Contact)

<400>  108

His Gln Tyr His Arg Ser Pro Pro 
1               5               


<210>  109
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VH Sequence

<400>  109

Gln Val Gln Leu Lys Glu Ser Gly Pro Asp Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Thr Ser Lys Arg Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ala Pro Ser Phe Ile Arg Tyr Gly Ser Arg Tyr Asp Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  110
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-14D12 VL Sequence

<400>  110

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Thr Ala Ser Ser Ser Val Thr Ser Ser 
            20                  25                  30          


Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  111
<211>  1049
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full-length amino acid sequence of human alpha5 integrin

<400>  111

Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp  Ile Ile Ile Leu Ala  Ile Leu Phe 
        995                 1000                 1005             


Gly Leu  Leu Leu Leu Gly Leu  Leu Ile Tyr Ile Leu  Tyr Lys Leu 
    1010                 1015                 1020             


Gly Phe  Phe Lys Arg Ser Leu  Pro Tyr Gly Thr Ala  Met Glu Lys 
    1025                 1030                 1035             


Ala Gln  Leu Lys Pro Pro Ala  Thr Ser Asp Ala 
    1040                 1045                 


<210>  112
<211>  1053
<212>  PRT
<213>  Mus

<220>
<223>  Full-length amino acid sequence of mouse alpha5 integrin

<400>  112

Met Gly Ser Trp Thr Pro Arg Ser Pro Arg Ser Pro Leu His Ala Val 
1               5                   10                  15      


Leu Leu Arg Trp Gly Pro Arg Arg Leu Pro Pro Leu Leu Pro Leu Leu 
            20                  25                  30          


Leu Leu Leu Trp Pro Pro Pro Leu Gln Val Gly Gly Phe Asn Leu Asp 
        35                  40                  45              


Ala Glu Ala Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Leu Phe Gly 
    50                  55                  60                  


Phe Ser Val Glu Phe Tyr Arg Pro Gly Arg Asp Gly Val Ser Val Leu 
65                  70                  75                  80  


Val Gly Ala Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly 
                85                  90                  95      


Gly Ala Val Tyr Val Cys Pro Trp Gly Thr Ser Pro Ile Gln Cys Thr 
            100                 105                 110         


Thr Ile Gln Phe Asp Ser Lys Gly Ser Arg Ile Leu Glu Ser Ser Leu 
        115                 120                 125             


Tyr Ser Ala Lys Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp 
    130                 135                 140                 


Phe Gly Ala Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala 
145                 150                 155                 160 


Pro Leu Tyr Ser Trp Arg Thr Glu Lys Asp Pro Gln Asn Asp Pro Val 
                165                 170                 175     


Gly Thr Cys Tyr Leu Ser Thr Glu Asn Phe Thr Arg Ile Leu Glu Tyr 
            180                 185                 190         


Ala Pro Cys Arg Ser Asp Phe Gly Ser Ala Ala Gly Gln Gly Tyr Cys 
        195                 200                 205             


Gln Gly Gly Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu 
    210                 215                 220                 


Gly Gly Pro Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr 
225                 230                 235                 240 


Gln Glu Gln Ile Ser Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Pro 
                245                 250                 255     


Val Gln Gly Gln Leu Gln Thr Arg Gln Ala Ser Ser Val Tyr Asp Asp 
            260                 265                 270         


Ser Tyr Leu Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp 
        275                 280                 285             


Thr Glu Asp Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly 
    290                 295                 300                 


Tyr Val Thr Val Leu Asn Gly Ser Asp Ile His Ser Leu Tyr Asn Val 
305                 310                 315                 320 


Ser Gly Glu Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr 
                325                 330                 335     


Asp Thr Asn Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu 
            340                 345                 350         


Leu Met Glu Arg Thr Ala Asp Gly Arg Pro Gln Glu Val Gly Arg Val 
        355                 360                 365             


Tyr Ile Tyr Leu Gln Arg Pro Ala Gly Ile Asp Pro Thr Pro Thr Leu 
    370                 375                 380                 


Thr Leu Thr Gly Gln Asp Glu Phe Ser Arg Phe Gly Ser Ser Leu Thr 
385                 390                 395                 400 


Pro Leu Gly Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly 
                405                 410                 415     


Ala Pro Phe Gly Gly Glu Ala Gln Gln Gly Val Val Phe Ile Phe Pro 
            420                 425                 430         


Gly Gly Pro Gly Gly Leu Ser Thr Lys Pro Ser Gln Val Leu Gln Pro 
        435                 440                 445             


Leu Trp Ala Ala Gly Arg Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg 
    450                 455                 460                 


Gly Gly Arg Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly 
465                 470                 475                 480 


Ser Phe Gly Val Asp Lys Ala Leu Val Tyr Arg Gly Arg Pro Ile Ile 
                485                 490                 495     


Ser Ala Ser Ala Ser Leu Thr Ile Phe Pro Ser Met Phe Asn Pro Glu 
            500                 505                 510         


Glu Arg Ser Cys Ser Leu Glu Gly Asn Pro Val Ser Cys Ile Asn Leu 
        515                 520                 525             


Ser Phe Cys Leu Asn Ala Ser Gly Lys His Val Pro Asn Ser Ile Gly 
    530                 535                 540                 


Phe Glu Val Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val 
545                 550                 555                 560 


Arg Arg Ala Leu Phe Leu Thr Ser Lys Gln Ala Thr Leu Thr Gln Thr 
                565                 570                 575     


Leu Leu Ile Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile 
            580                 585                 590         


Tyr Leu Arg Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His 
        595                 600                 605             


Ile Ala Leu Asn Phe Ser Leu Asp Pro Lys Ala Pro Met Asp Ser His 
    610                 615                 620                 


Gly Leu Arg Pro Val Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp 
625                 630                 635                 640 


Lys Ala Gln Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro 
                645                 650                 655     


Asp Leu Gln Leu Asp Val Tyr Gly Glu Lys Lys His Val Tyr Leu Gly 
            660                 665                 670         


Asp Lys Asn Ala Leu Asn Leu Thr Phe His Ala Gln Asn Leu Gly Glu 
        675                 680                 685             


Gly Gly Ala Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Leu Glu Ala 
    690                 695                 700                 


Glu Tyr Ser Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser 
705                 710                 715                 720 


Cys Asp Tyr Phe Ala Val Asn Gln Ser Arg Gln Leu Val Cys Asp Leu 
                725                 730                 735     


Gly Asn Pro Met Lys Ala Gly Thr Ser Leu Trp Gly Gly Leu Arg Phe 
            740                 745                 750         


Thr Val Pro His Leu Gln Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe 
        755                 760                 765             


Gln Ile Leu Ser Lys Asn Leu Asn Asn Ser Gln Ser Asn Val Val Ser 
    770                 775                 780                 


Phe Pro Leu Ser Val Glu Ala Gln Ala Gln Val Ser Leu Asn Gly Val 
785                 790                 795                 800 


Ser Lys Pro Glu Ala Val Ile Phe Pro Val Ser Asp Trp Asn Pro Gln 
                805                 810                 815     


Asp Gln Pro Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val 
            820                 825                 830         


Tyr Glu Leu Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu 
        835                 840                 845             


Glu Leu Ser Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val 
    850                 855                 860                 


Thr Lys Val Thr Gly Leu Ser Asn Cys Thr Ser Asn Tyr Thr Pro Asn 
865                 870                 875                 880 


Ser Gln Gly Leu Glu Leu Asp Pro Glu Thr Ser Pro His His Leu Gln 
                885                 890                 895     


Lys Arg Glu Ala Pro Gly Arg Ser Ser Thr Ala Ser Gly Thr Gln Val 
            900                 905                 910         


Leu Lys Cys Pro Glu Ala Lys Cys Phe Arg Leu Arg Cys Glu Phe Gly 
        915                 920                 925             


Pro Leu His Arg Gln Glu Ser Arg Ser Leu Gln Leu His Phe Arg Val 
    930                 935                 940                 


Trp Ala Lys Thr Phe Leu Gln Arg Glu Tyr Gln Pro Phe Ser Leu Gln 
945                 950                 955                 960 


Cys Glu Ala Val Tyr Glu Ala Leu Lys Met Pro Tyr Gln Ile Leu Pro 
                965                 970                 975     


Arg Gln Leu Pro Gln Lys Lys Leu Gln Val Ala Thr Ala Val Gln Trp 
            980                 985                 990         


Thr Lys Ala Glu Gly Ser Asn Gly  Val Pro Leu Trp Ile  Ile Ile Leu 
        995                 1000                 1005             


Ala Ile  Leu Phe Gly Leu Leu  Leu Leu Gly Leu Leu  Ile Tyr Val 
    1010                 1015                 1020             


Leu Tyr  Lys Leu Gly Phe Phe  Lys Arg Ser Leu Pro  Tyr Gly Thr 
    1025                 1030                 1035             


Ala Met  Glu Lys Ala Gln Leu  Lys Pro Pro Ala Thr  Ser Asp Ala 
    1040                 1045                 1050             


<210>  113
<211>  798
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full-length amino acid sequence of human beta1 integrin

<400>  113

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  114
<211>  798
<212>  PRT
<213>  Mus

<220>
<223>  Full-length amino acid sequence of mouse beta1 integrin

<400>  114

Met Asn Leu Gln Leu Val Ser Trp Ile Gly Leu Ile Ser Leu Ile Cys 
1               5                   10                  15      


Ser Val Phe Gly Gln Thr Asp Lys Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Thr Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Gln Pro Ser Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Gln Thr Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Met Ala Glu Lys Leu Arg Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Leu Leu Lys Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Lys Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asp Arg Gly Glu Phe Phe Asn Glu Leu Val Gly Gln Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Val Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Gly Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Ser Lys Leu Pro Asp Gly Val Thr Ile Asn Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ala 
            420                 425                 430         


Asn Lys Cys Pro Asn Lys Glu Ser Glu Thr Ile Lys Ile Lys Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Val Leu Gln Phe Ile Cys Lys Cys 
    450                 455                 460                 


Asn Cys Gln Ser His Gly Ile Pro Ala Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Arg Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Tyr Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Gly Pro Cys Leu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Ala Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Pro Thr Cys Glu Thr Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Ala Gln Glu Cys Ser His Phe Asn Leu Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Glu Lys Leu Pro Gln Pro Val Gln Val Asp Pro Val 
        675                 680                 685             


Thr His Cys Lys Glu Lys Asp Ile Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Ala Ile Val His Val Val Glu Thr 
705                 710                 715                 720 


Pro Asp Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  115
<211>  1032
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full-length amino acid sequence of human alpha4 integrin

<400>  115

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210>  116
<211>  2477
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Full-length amino acid sequence of human fibronectin

<400>  116

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 
    1265                 1270                 1275             


Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 
    1280                 1285                 1290             


Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 
    1295                 1300                 1305             


Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 
    1310                 1315                 1320             


Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 
    1325                 1330                 1335             


Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 
    1340                 1345                 1350             


Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 
    1355                 1360                 1365             


Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 
    1370                 1375                 1380             


Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 
    1385                 1390                 1395             


Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 
    1400                 1405                 1410             


Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 
    1415                 1420                 1425             


Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 
    1430                 1435                 1440             


Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 
    1445                 1450                 1455             


Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 
    1460                 1465                 1470             


Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 
    1475                 1480                 1485             


Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 
    1490                 1495                 1500             


Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 
    1505                 1510                 1515             


Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 
    1520                 1525                 1530             


Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 
    1535                 1540                 1545             


Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 
    1550                 1555                 1560             


Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 
    1565                 1570                 1575             


Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 
    1580                 1585                 1590             


Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 
    1595                 1600                 1605             


Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 
    1610                 1615                 1620             


Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 
    1625                 1630                 1635             


Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 
    1640                 1645                 1650             


Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 
    1655                 1660                 1665             


Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 
    1670                 1675                 1680             


Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 
    1685                 1690                 1695             


Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 
    1700                 1705                 1710             


Pro Leu  Val Gln Thr Ala Val  Thr Asn Ile Asp Arg  Pro Lys Gly 
    1715                 1720                 1725             


Leu Ala  Phe Thr Asp Val Asp  Val Asp Ser Ile Lys  Ile Ala Trp 
    1730                 1735                 1740             


Glu Ser  Pro Gln Gly Gln Val  Ser Arg Tyr Arg Val  Thr Tyr Ser 
    1745                 1750                 1755             


Ser Pro  Glu Asp Gly Ile His  Glu Leu Phe Pro Ala  Pro Asp Gly 
    1760                 1765                 1770             


Glu Glu  Asp Thr Ala Glu Leu  Gln Gly Leu Arg Pro  Gly Ser Glu 
    1775                 1780                 1785             


Tyr Thr  Val Ser Val Val Ala  Leu His Asp Asp Met  Glu Ser Gln 
    1790                 1795                 1800             


Pro Leu  Ile Gly Thr Gln Ser  Thr Ala Ile Pro Ala  Pro Thr Asp 
    1805                 1810                 1815             


Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 
    1820                 1825                 1830             


Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 
    1835                 1840                 1845             


Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 
    1850                 1855                 1860             


Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 
    1865                 1870                 1875             


Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 
    1880                 1885                 1890             


Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 
    1895                 1900                 1905             


Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 
    1910                 1915                 1920             


Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 
    1925                 1930                 1935             


Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 
    1940                 1945                 1950             


Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 
    1955                 1960                 1965             


Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 
    1970                 1975                 1980             


Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 
    1985                 1990                 1995             


Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 
    2000                 2005                 2010             


Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 
    2015                 2020                 2025             


Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 
    2030                 2035                 2040             


Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 
    2045                 2050                 2055             


Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 
    2060                 2065                 2070             


Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Asp Glu Leu  Pro Gln Leu 
    2075                 2080                 2085             


Val Thr  Leu Pro His Pro Asn  Leu His Gly Pro Glu  Ile Leu Asp 
    2090                 2095                 2100             


Val Pro  Ser Thr Val Gln Lys  Thr Pro Phe Val Thr  His Pro Gly 
    2105                 2110                 2115             


Tyr Asp  Thr Gly Asn Gly Ile  Gln Leu Pro Gly Thr  Ser Gly Gln 
    2120                 2125                 2130             


Gln Pro  Ser Val Gly Gln Gln  Met Ile Phe Glu Glu  His Gly Phe 
    2135                 2140                 2145             


Arg Arg  Thr Thr Pro Pro Thr  Thr Ala Thr Pro Ile  Arg His Arg 
    2150                 2155                 2160             


Pro Arg  Pro Tyr Pro Pro Asn  Val Gly Glu Glu Ile  Gln Ile Gly 
    2165                 2170                 2175             


His Ile  Pro Arg Glu Asp Val  Asp Tyr His Leu Tyr  Pro His Gly 
    2180                 2185                 2190             


Pro Gly  Leu Asn Pro Asn Ala  Ser Thr Gly Gln Glu  Ala Leu Ser 
    2195                 2200                 2205             


Gln Thr  Thr Ile Ser Trp Ala  Pro Phe Gln Asp Thr  Ser Glu Tyr 
    2210                 2215                 2220             


Ile Ile  Ser Cys His Pro Val  Gly Thr Asp Glu Glu  Pro Leu Gln 
    2225                 2230                 2235             


Phe Arg  Val Pro Gly Thr Ser  Thr Ser Ala Thr Leu  Thr Gly Leu 
    2240                 2245                 2250             


Thr Arg  Gly Ala Thr Tyr Asn  Val Ile Val Glu Ala  Leu Lys Asp 
    2255                 2260                 2265             


Gln Gln  Arg His Lys Val Arg  Glu Glu Val Val Thr  Val Gly Asn 
    2270                 2275                 2280             


Ser Val  Asn Glu Gly Leu Asn  Gln Pro Thr Asp Asp  Ser Cys Phe 
    2285                 2290                 2295             


Asp Pro  Tyr Thr Val Ser His  Tyr Ala Val Gly Asp  Glu Trp Glu 
    2300                 2305                 2310             


Arg Met  Ser Glu Ser Gly Phe  Lys Leu Leu Cys Gln  Cys Leu Gly 
    2315                 2320                 2325             


Phe Gly  Ser Gly His Phe Arg  Cys Asp Ser Ser Arg  Trp Cys His 
    2330                 2335                 2340             


Asp Asn  Gly Val Asn Tyr Lys  Ile Gly Glu Lys Trp  Asp Arg Gln 
    2345                 2350                 2355             


Gly Glu  Asn Gly Gln Met Met  Ser Cys Thr Cys Leu  Gly Asn Gly 
    2360                 2365                 2370             


Lys Gly  Glu Phe Lys Cys Asp  Pro His Glu Ala Thr  Cys Tyr Asp 
    2375                 2380                 2385             


Asp Gly  Lys Thr Tyr His Val  Gly Glu Gln Trp Gln  Lys Glu Tyr 
    2390                 2395                 2400             


Leu Gly  Ala Ile Cys Ser Cys  Thr Cys Phe Gly Gly  Gln Arg Gly 
    2405                 2410                 2415             


Trp Arg  Cys Asp Asn Cys Arg  Arg Pro Gly Gly Glu  Pro Ser Pro 
    2420                 2425                 2430             


Glu Gly  Thr Thr Gly Gln Ser  Tyr Asn Gln Tyr Ser  Gln Arg Tyr 
    2435                 2440                 2445             


His Gln  Arg Thr Asn Thr Asn  Val Asn Cys Pro Ile  Glu Cys Phe 
    2450                 2455                 2460             


Met Pro  Leu Asp Val Gln Ala  Asp Arg Glu Asp Ser  Arg Glu 
    2465                 2470                 2475         


<210>  117
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary IgG heavy chain comprises any VH domain

<400>  117

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  118
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary IgG heavy chain comprises any VH domain

<400>  118

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  119
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary light chain (e.g., for pairing with an IgG heavy chain)
       comprises any VL domain

<400>  119

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Ser 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VH CDR1


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a naturally occurring amino acid (e.g., S, T, or D)

<400>  120

Gly Phe Ser Leu Thr Xaa Tyr Gly Val His 
1               5                   10  


<210>  121
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VH CDR2


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is a naturally occurring amino acid (e.g., N, Q, S, or A)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is a naturally occurring amino acid (e.g., A or T)

<400>  121

Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Xaa Ser Xaa Leu Lys Ser 
1               5                   10                  15      


<210>  122
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VH CDR3


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is a naturally occurring amino acid (e.g., Y, G, or A)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a naturally occurring amino acid (e.g., D, G, or P)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a naturally occurring amino acid (e.g., Y, L, or S)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a naturally occurring amino acid (e.g., D, L, or F)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a naturally occurring amino acid (e.g., G, R, or I)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a naturally occurring amino acid (e.g., D or R)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is a naturally occurring amino acid (e.g., W, D, or Y)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is a naturally occurring amino acid (e.g., F, A, or G)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a naturally occurring amino acid (e.g., absent, M, or S)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is a naturally occurring amino acid (e.g., D or A)

<400>  122

His Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr 
1               5                   10          


<210>  123
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VH CDR3


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is a naturally occurring amino acid (e.g., Y, G, or A)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a naturally occurring amino acid (e.g., D, G, or P)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a naturally occurring amino acid (e.g., Y, L, or S)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a naturally occurring amino acid (e.g., D, L, or F)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a naturally occurring amino acid (e.g., G, R, or I)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a naturally occurring amino acid (e.g., D or R)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is a naturally occurring amino acid (e.g., W, D, or Y)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is a naturally occurring amino acid (e.g., F, A, or G)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a naturally occurring amino acid (e.g., absent, M, or S)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is a naturally occurring amino acid (e.g., D or A)

<400>  123

His Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Tyr Asp Ala Leu Xaa 
1               5                   10                  15      


Tyr 
    


<210>  124
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VL CDR1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a naturally occurring amino acid (e.g., R or S)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a naturally occurring amino acid (e.g., S or T)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is a naturally occurring amino acid (e.g., N, R, or S)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a naturally occurring amino acid (e.g., S, F, C, A, or V)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is a naturally occurring amino acid (e.g., L or F)

<400>  124

Thr Ala Ser Ser Xaa Val Xaa Ser Xaa Xaa Xaa His 
1               5                   10          


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VL CDR2

<400>  125

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VL CDR3


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a naturally occurring amino acid (e.g., L, Y, or H)

<400>  126

His Gln Tyr Xaa Arg Ser Pro Pro Thr 
1               5                   


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VH CDR1

<400>  127

Gly Tyr Thr Phe Thr Ile Tyr Trp Ile Asn 
1               5                   10  


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VH CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is a naturally occurring amino acid (e.g., K or N)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a naturally occurring amino acid (e.g., I or S)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a naturally occurring amino acid (e.g., D or N)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is a naturally occurring amino acid (e.g., S or T)

<400>  128

Xaa Ile Tyr Pro Gly Ser Xaa Ser Thr Xaa Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Xaa 
    


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VH CDR3


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a naturally occurring amino acid (e.g., absent, L, or F)

<400>  129

Thr Gly Thr Gly Gly Xaa Ala Tyr 
1               5               


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VL CDR1

<400>  130

Arg Ala Ser Ser Ser Val Asn Tyr Met Tyr 
1               5                   10  


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VL CDR2

<400>  131

Phe Thr Ser Ser Leu Ala Pro 
1               5           


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence - VL CDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a naturally occurring amino acid (e.g., F or L)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a naturally occurring amino acid (e.g., T or G)

<400>  132

Gln Gln Xaa Thr Xaa Ser Pro Phe Thr 
1               5                   


<210>  133
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary Fc region sequence

<400>  133

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  134
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary variant Fc region ("silent Fc") sequence

<400>  134

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  135
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A-15B08-T62A VH Sequence

<400>  135

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Asp Tyr Asp Gly Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  136
<211>  119
<212>  PRT
<213>  Homo sapiens

<220>
<223>  A-15B08_HC_Low VH Sequence

<400>  136

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Val Phe 
65                  70                  75                  80  


Thr Met Thr Asn Leu Asp Thr Val Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Asp Tyr Asp Gly Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  137
<211>  108
<212>  PRT
<213>  Homo sapiens

<220>
<223>  A-15B08_LC_Low VL Sequence

<400>  137

Glu Ile Val Leu Thr Gln Ser Pro Gly Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Arg Ala Ser Ser Arg Val Ser Ser Asn 
            20                  25                  30          


Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Met Glu 
65                  70                  75                  80  


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  138
<211>  119
<212>  PRT
<213>  Homo sapiens

<220>
<223>  A-15B08_HC_Low+Mod VH Sequence

<400>  138

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Phe 
65                  70                  75                  80  


Thr Met Thr Asn Leu Asp Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Tyr Asp Tyr Asp Gly Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  139
<211>  108
<212>  PRT
<213>  Homo sapiens

<220>
<223>  A-15B08_LC_Low+Mod VL Sequence

<400>  139

Glu Ile Val Leu Thr Gln Ser Pro Gly Ile Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Arg Ala Ser Ser Arg Val Ser Ser Asn 
            20                  25                  30          


Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Met Glu 
65                  70                  75                  80  


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  140
<211>  117
<212>  PRT
<213>  Homo sapiens

<220>
<223>  A2-7A05_HC_Low VH Sequence

<400>  140

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Tyr Pro Gly Ser Ile Ser Thr Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Thr Gly Thr Gly Gly Leu Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  141
<211>  106
<212>  PRT
<213>  Homo sapiens

<220>
<223>  A2-7A05_LC_Low VL Sequence

<400>  141

Glu Asn Val Leu Thr Gln Ser Pro Gly Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Phe Thr Ser Ser Arg Ala Pro Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Arg Met Glu Gly Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Thr Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  142
<211>  117
<212>  PRT
<213>  Homo sapiens

<220>
<223>  A2-7A05_HC_Low+Mod VH Sequence

<400>  142

Gln Val Gln Leu Val Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Tyr Pro Gly Ser Ile Ser Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Thr Gly Thr Gly Gly Leu Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  143
<211>  106
<212>  PRT
<213>  Homo sapiens

<220>
<223>  A2-7A05_LC_Low+Mod VL Sequence

<400>  143

Glu Asn Val Leu Thr Gln Ser Pro Gly Ile Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              


Phe Thr Ser Ser Arg Ala Pro Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Arg Met Glu Gly Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Thr Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  144
<211>  125
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C-14D12_HC_Low VH Sequence

<400>  144

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Arg Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Leu Asp Thr Val Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ala Pro Ser Phe Ile Arg Tyr Gly Ser Arg Tyr Asp Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  145
<211>  108
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C-14D12_LC_Low VL Sequence

<400>  145

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Thr Ser Ser 
            20                  25                  30          


Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Met Glu 
65                  70                  75                  80  


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  146
<211>  125
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C-14D12_HC_Low+Mod VH Sequence

<400>  146

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Thr Thr Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Leu Asp Thr Val Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ala Pro Ser Phe Ile Arg Tyr Gly Ser Arg Tyr Asp Ala Leu 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  147
<211>  108
<212>  PRT
<213>  Homo sapiens

<220>
<223>  C-14D12_LC_Low+Mod VL Sequence

<400>  147

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Thr Ser Ser 
            20                  25                  30          


Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Met Glu 
65                  70                  75                  80  


Ala Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  148
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1

<400>  148

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  149
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4

<400>  149

Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215                 220         


<210>  150
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N297A/Q (N297A or N297Q)

<400>  150

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  151
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LALA (L234A, L235A)

<400>  151

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  152
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LALAPS (L234A, L235A, P331S)

<400>  152

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  153
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LALAPG (L234A, L235A, P329G)

<400>  153

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  154
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TM (L234F, L235E, P331S)

<400>  154

Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


