               SEQUENCE LISTING

<110> Universidade do Algarve

<120> Isolated or artificial nucleotides for use in neurodegenerative diseases

<130> P1268.8

<150> PT117230
<151> 2021-05-13

<160> 17

<170> BiSSAP 1.3.6

<210> 1
<211> 1401
<212> DNA
<213> Artificial Sequence


<220> 
<223> G3BP1

<400> 1
atggtgatgg agaagcctag tcccctgctg gtcgggcggg aatttgtgag acagtattac      60

acactgctga accaggcccc agacatgctg catagatttt atggaaagaa ctcttcttat     120

gtccatgggg gattggattc aaatggaaag ccagcagatg cagtctacgg acagaaagaa     180

atccacagga aagtgatgtc acaaaacttc accaactgcc acaccaagat tcgccatgtt     240

gatgctcatg ccacgctaaa tgatggtgtg gtagtccagg tgatggggct tctctctaac     300

aacaaccagg ctttgaggag attcatgcaa acgtttgtcc ttgctcctga ggggtctgtt     360

gcaaataaat tctatgttca caatgatatc ttcagatacc aagatgaggt ctttggtggg     420

tttgtcactg agcctcagga ggagtctgaa gaagaagtag aggaacctga agaaagacag     480

caaacacctg aggtggtacc tgatgattct ggaactttct atgatcaggc agttgtcagt     540

aatgacatgg aagaacattt agaggagcct gttgctgaac cagagcctga tcctgaacca     600

gaaccagaac aagaacctgt atctgaaatc caagaggaaa agcctgagcc agtattagaa     660

gaaactgccc ctgaggatgc tcagaagagt tcttctccag cacctgcaga catagctcag     720

acagtacagg aagacttgag gacattttct tgggcatctg tgaccagtaa gaatcttcca     780

cccagtggag ctgttccagt tactgggata ccacctcatg ttgttaaagt accagcttca     840

cagccccgtc cagagtctaa gcctgaatct cagattccac cacaaagacc tcagcgggat     900

caaagagtgc gagaacaacg aataaatatt cctccccaaa ggggacccag accaatccgt     960

gaggctggtg agcaaggtga cattgaaccc cgaagaatgg tgagacaccc tgacagtcac    1020

caactcttca ttggcaacct gcctcatgaa gtggacaaat cagagcttaa agatttcttt    1080

caaagttatg gaaacgtggt ggagttgcgc attaacagtg gtgggaaatt acccaatttt    1140

ggttttgttg tgtttgatga ttctgagcct gttcagaaag tccttagcaa caggcccatc    1200

atgttcagag gtgaggtccg tctgaatgtc gaagagaaga agactcgagc tgccagggaa    1260

ggcgaccgac gagataatcg ccttcgggga cctggaggcc ctcgaggtgg gctgggtggt    1320

ggaatgagag gccctccccg tggaggcatg gtgcagaaac caggatttgg agtgggaagg    1380

gggcttgcgc cacggcagta g                                              1401


<210> 2
<211> 369
<212> DNA
<213> Artificial Sequence


<220> 
<223> G3BP1 NTF2-like domain

<400> 2
gtcgggcggg aatttgtgag acagtattac acactgctga accaggcccc agacatgctg      60

catagatttt atggaaagaa ctcttcttat gtccatgggg gattggattc aaatggaaag     120

ccagcagatg cagtctacgg acagaaagaa atccacagga aagtgatgtc acaaaacttc     180

accaactgcc acaccaagat tcgccatgtt gatgctcatg ccacgctaaa tgatggtgtg     240

gtagtccagg tgatggggct tctctctaac aacaaccagg ctttgaggag attcatgcaa     300

acgtttgtcc ttgctcctga ggggtctgtt gcaaataaat tctatgttca caatgatatc     360

ttcagatac                                                             369


<210> 3
<211> 228
<212> DNA
<213> Artificial Sequence


<220> 
<223> G3BP1 RRM

<400> 3
caccaactct tcattggcaa cctgcctcat gaagtggaca aatcagagct taaagatttc     60

tttcaaagtt atggaaacgt ggtggagttg cgcattaaca gtggtgggaa attacccaat    120

tttggttttg ttgtgtttga tgattctgag cctgttcaga aagtccttag caacaggccc    180

atcatgttca gaggtgaggt ccgtctgaat gtcgaagaga agaagact                 228


<210> 4
<211> 1032
<212> DNA
<213> Artificial Sequence


<220> 
<223> G3BP1 deletion NTF2-like domain

<400> 4
atggtgatgg agaagcctag tcccctgctg caagatgagg tctttggtgg gtttgtcact      60

gagcctcagg aggagtctga agaagaagta gaggaacctg aagaaagaca gcaaacacct     120

gaggtggtac ctgatgattc tggaactttc tatgatcagg cagttgtcag taatgacatg     180

gaagaacatt tagaggagcc tgttgctgaa ccagagcctg atcctgaacc agaaccagaa     240

caagaacctg tatctgaaat ccaagaggaa aagcctgagc cagtattaga agaaactgcc     300

cctgaggatg ctcagaagag ttcttctcca gcacctgcag acatagctca gacagtacag     360

gaagacttga ggacattttc ttgggcatct gtgaccagta agaatcttcc acccagtgga     420

gctgttccag ttactgggat accacctcat gttgttaaag taccagcttc acagccccgt     480

ccagagtcta agcctgaatc tcagattcca ccacaaagac ctcagcggga tcaaagagtg     540

cgagaacaac gaataaatat tcctccccaa aggggaccca gaccaatccg tgaggctggt     600

gagcaaggtg acattgaacc ccgaagaatg gtgagacacc ctgacagtca ccaactcttc     660

attggcaacc tgcctcatga agtggacaaa tcagagctta aagatttctt tcaaagttat     720

ggaaacgtgg tggagttgcg cattaacagt ggtgggaaat tacccaattt tggttttgtt     780

gtgtttgatg attctgagcc tgttcagaaa gtccttagca acaggcccat catgttcaga     840

ggtgaggtcc gtctgaatgt cgaagagaag aagactcgag ctgccaggga aggcgaccga     900

cgagataatc gccttcgggg acctggaggc cctcgaggtg ggctgggtgg tggaatgaga     960

ggccctcccc gtggaggcat ggtgcagaaa ccaggatttg gagtgggaag ggggcttgcg    1020

ccacggcagt ag                                                        1032


<210> 5
<211> 1173
<212> DNA
<213> Artificial Sequence


<220> 
<223> G3BP1 deletion RRM

<400> 5
atggtgatgg agaagcctag tcccctgctg gtcgggcggg aatttgtgag acagtattac      60

acactgctga accaggcccc agacatgctg catagatttt atggaaagaa ctcttcttat     120

gtccatgggg gattggattc aaatggaaag ccagcagatg cagtctacgg acagaaagaa     180

atccacagga aagtgatgtc acaaaacttc accaactgcc acaccaagat tcgccatgtt     240

gatgctcatg ccacgctaaa tgatggtgtg gtagtccagg tgatggggct tctctctaac     300

aacaaccagg ctttgaggag attcatgcaa acgtttgtcc ttgctcctga ggggtctgtt     360

gcaaataaat tctatgttca caatgatatc ttcagatacc aagatgaggt ctttggtggg     420

tttgtcactg agcctcagga ggagtctgaa gaagaagtag aggaacctga agaaagacag     480

caaacacctg aggtggtacc tgatgattct ggaactttct atgatcaggc agttgtcagt     540

aatgacatgg aagaacattt agaggagcct gttgctgaac cagagcctga tcctgaacca     600

gaaccagaac aagaacctgt atctgaaatc caagaggaaa agcctgagcc agtattagaa     660

gaaactgccc ctgaggatgc tcagaagagt tcttctccag cacctgcaga catagctcag     720

acagtacagg aagacttgag gacattttct tgggcatctg tgaccagtaa gaatcttcca     780

cccagtggag ctgttccagt tactgggata ccacctcatg ttgttaaagt accagcttca     840

cagccccgtc cagagtctaa gcctgaatct cagattccac cacaaagacc tcagcgggat     900

caaagagtgc gagaacaacg aataaatatt cctccccaaa ggggacccag accaatccgt     960

gaggctggtg agcaaggtga cattgaaccc cgaagaatgg tgagacaccc tgacagtcga    1020

gctgccaggg aaggcgaccg acgagataat cgccttcggg gacctggagg ccctcgaggt    1080

gggctgggtg gtggaatgag aggccctccc cgtggaggca tggtgcagaa accaggattt    1140

ggagtgggaa gggggcttgc gccacggcag tag                                 1173


<210> 6
<211> 1401
<212> DNA
<213> Artificial Sequence


<220> 
<223> G3BP1 pospho Ser149A

<400> 6
atggtgatgg agaagcctag tcccctgctg gtcgggcggg aatttgtgag acagtattac      60

acactgctga accaggcccc agacatgctg catagatttt atggaaagaa ctcttcttat     120

gtccatgggg gattggattc aaatggaaag ccagcagatg cagtctacgg acagaaagaa     180

atccacagga aagtgatgtc acaaaacttc accaactgcc acaccaagat tcgccatgtt     240

gatgctcatg ccacgctaaa tgatggtgtg gtagtccagg tgatggggct tctctctaac     300

aacaaccagg ctttgaggag attcatgcaa acgtttgtcc ttgctcctga ggggtctgtt     360

gcaaataaat tctatgttca caatgatatc ttcagatacc aagatgaggt ctttggtggg     420

tttgtcactg agcctcagga ggaggctgaa gaagaagtag aggaacctga agaaagacag     480

caaacacctg aggtggtacc tgatgattct ggaactttct atgatcaggc agttgtcagt     540

aatgacatgg aagaacattt agaggagcct gttgctgaac cagagcctga tcctgaacca     600

gaaccagaac aagaacctgt atctgaaatc caagaggaaa agcctgagcc agtattagaa     660

gaaactgccc ctgaggatgc tcagaagagt tcttctccag cacctgcaga catagctcag     720

acagtacagg aagacttgag gacattttct tgggcatctg tgaccagtaa gaatcttcca     780

cccagtggag ctgttccagt tactgggata ccacctcatg ttgttaaagt accagcttca     840

cagccccgtc cagagtctaa gcctgaatct cagattccac cacaaagacc tcagcgggat     900

caaagagtgc gagaacaacg aataaatatt cctccccaaa ggggacccag accaatccgt     960

gaggctggtg agcaaggtga cattgaaccc cgaagaatgg tgagacaccc tgacagtcac    1020

caactcttca ttggcaacct gcctcatgaa gtggacaaat cagagcttaa agatttcttt    1080

caaagttatg gaaacgtggt ggagttgcgc attaacagtg gtgggaaatt acccaatttt    1140

ggttttgttg tgtttgatga ttctgagcct gttcagaaag tccttagcaa caggcccatc    1200

atgttcagag gtgaggtccg tctgaatgtc gaagagaaga agactcgagc tgccagggaa    1260

ggcgaccgac gagataatcg ccttcgggga cctggaggcc ctcgaggtgg gctgggtggt    1320

ggaatgagag gccctccccg tggaggcatg gtgcagaaac caggatttgg agtgggaagg    1380

gggcttgcgc cacggcagta g                                              1401


<210> 7
<211> 1401
<212> DNA
<213> Artificial Sequence


<220> 
<223> G3BP1 pospho Ser149D

<400> 7
atggtgatgg agaagcctag tcccctgctg gtcgggcggg aatttgtgag acagtattac      60

acactgctga accaggcccc agacatgctg catagatttt atggaaagaa ctcttcttat     120

gtccatgggg gattggattc aaatggaaag ccagcagatg cagtctacgg acagaaagaa     180

atccacagga aagtgatgtc acaaaacttc accaactgcc acaccaagat tcgccatgtt     240

gatgctcatg ccacgctaaa tgatggtgtg gtagtccagg tgatggggct tctctctaac     300

aacaaccagg ctttgaggag attcatgcaa acgtttgtcc ttgctcctga ggggtctgtt     360

gcaaataaat tctatgttca caatgatatc ttcagatacc aagatgaggt ctttggtggg     420

tttgtcactg agcctcagga ggaggatgaa gaagaagtag aggaacctga agaaagacag     480

caaacacctg aggtggtacc tgatgattct ggaactttct atgatcaggc agttgtcagt     540

aatgacatgg aagaacattt agaggagcct gttgctgaac cagagcctga tcctgaacca     600

gaaccagaac aagaacctgt atctgaaatc caagaggaaa agcctgagcc agtattagaa     660

gaaactgccc ctgaggatgc tcagaagagt tcttctccag cacctgcaga catagctcag     720

acagtacagg aagacttgag gacattttct tgggcatctg tgaccagtaa gaatcttcca     780

cccagtggag ctgttccagt tactgggata ccacctcatg ttgttaaagt accagcttca     840

cagccccgtc cagagtctaa gcctgaatct cagattccac cacaaagacc tcagcgggat     900

caaagagtgc gagaacaacg aataaatatt cctccccaaa ggggacccag accaatccgt     960

gaggctggtg agcaaggtga cattgaaccc cgaagaatgg tgagacaccc tgacagtcac    1020

caactcttca ttggcaacct gcctcatgaa gtggacaaat cagagcttaa agatttcttt    1080

caaagttatg gaaacgtggt ggagttgcgc attaacagtg gtgggaaatt acccaatttt    1140

ggttttgttg tgtttgatga ttctgagcct gttcagaaag tccttagcaa caggcccatc    1200

atgttcagag gtgaggtccg tctgaatgtc gaagagaaga agactcgagc tgccagggaa    1260

ggcgaccgac gagataatcg ccttcgggga cctggaggcc ctcgaggtgg gctgggtggt    1320

ggaatgagag gccctccccg tggaggcatg gtgcagaaac caggatttgg agtgggaagg    1380

gggcttgcgc cacggcagta g                                              1401


<210> 8
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primers

<400> 8
ctgagcctca ggaggaggct gaagaagaag tagag                                35


<210> 9
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primers

<400> 9
ctctacttct tcttcagcct cctcctgagg ctcag                                35


<210> 10
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primers

<400> 10
ctgagcctca ggaggaggat gaagaagaag tagag                                35


<210> 11
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primers

<400> 11
ctctacttct tcttcatcct cctcctgagg ctcag                                35


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primers

<400> 12
gaaatccaag aggaaaagcc                                                20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primers

<400> 13
cccaagaaaa tgtcctcaag                                                20


<210> 14
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primers

<400> 14
acagttgcca tgtagacc                                                  18


<210> 15
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primers

<400> 15
ttgagcacag ggtacttta                                                 19


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primers

<400> 16
agggatttga atcacgtttg                                                20


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primers

<400> 17
tttactggca acatcaacag                                                20


