               SEQUENCE LISTING

<110> Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO)
      Universitat Autònoma de Barcelona

<120> Recombinant TERT-encoding viral genomes and vectors

<130> 906 893

<150> EP21382441.0
<151> 2021-05-12

<160> 46

<170> BiSSAP 1.3.6

<210> 1
<211> 3786
<212> DNA
<213> Mus musculus


<220> 
<223> mTERT CDS + native 3' UTR

<400> 1
atgacccgcg ctcctcgttg ccccgcggtg cgctctctgc tgcgcagccg ataccgggag       60

gtgtggccgc tggcaacctt tgtgcggcgc ctggggcccg agggcaggcg gcttgtgcaa      120

cccggggacc cgaagatcta ccgcactttg gttgcccaat gcctagtgtg catgcactgg      180

ggctcacagc ctccacctgc cgacctttcc ttccaccagg tgtcatccct gaaagagctg      240

gtggccaggg ttgtgcagag actctgcgag cgcaacgaga gaaacgtgct ggcttttggc      300

tttgagctgc ttaacgaggc cagaggcggg cctcccatgg ccttcactag tagcgtgcgt      360

agctacttgc ccaacactgt tattgagacc ctgcgtgtca gtggtgcatg gatgctactg      420

ttgagccgag tgggcgacga cctgctggtc tacctgctgg cacactgtgc tctttatctt      480

ctggtgcccc ccagctgtgc ctaccaggtg tgtgggtctc ccctgtacca aatttgtgcc      540

accacggata tctggccctc tgtgtccgct agttacaggc ccacccgacc cgtgggcagg      600

aatttcacta accttaggtt cttacaacag atcaagagca gtagtcgcca ggaagcaccg      660

aaacccctgg ccttgccatc tcgaggtaca aagaggcatc tgagtctcac cagtacaagt      720

gtgccttcag ctaagaaggc cagatgctat cctgtcccga gagtggagga gggaccccac      780

aggcaggtgc taccaacccc atcaggcaaa tcatgggtgc caagtcctgc tcggtccccc      840

gaggtgccta ctgcagagaa agatttgtct tctaaaggaa aggtgtctga cctgagtctc      900

tctgggtcgg tgtgctgtaa acacaagccc agctccacat ctctgctgtc accaccccgc      960

caaaatgcct ttcagctcag gccatttatt gagaccagac atttccttta ctccagggga     1020

gatggccaag agcgtctaaa cccctcattc ctactcagca acctccagcc taacttgact     1080

ggggccagga gactggtgga gatcatcttt ctgggctcaa ggcctaggac atcaggacca     1140

ctctgcagga cacaccgtct atcgcgtcga tactggcaga tgcggcccct gttccaacag     1200

ctgctggtga accatgcaga gtgccaatat gtcagactcc tcaggtcaca ttgcaggttt     1260

cgaacagcaa accaacaggt gacagatgcc ttgaacacca gcccaccgca cctcatggat     1320

ttgctccgcc tgcacagcag tccctggcag gtatatggtt ttcttcgggc ctgtctctgc     1380

aaggtggtgt ctgctagtct ctggggtacc aggcacaatg agcgccgctt ctttaagaac     1440

ttaaagaagt tcatctcgtt ggggaaatac ggcaagctat cactgcagga actgatgtgg     1500

aagatgaaag tagaggattg ccactggctc cgcagcagcc cggggaagga ccgtgtcccc     1560

gctgcagagc accgtctgag ggagaggatc ctggctacgt tcctgttctg gctgatggac     1620

acatacgtgg tacagctgct taggtcattc ttttacatca cagagagcac attccagaag     1680

aacaggctct tcttctaccg taagagtgtg tggagcaagc tgcagagcat tggagtcagg     1740

caacaccttg agagagtgcg gctacgggag ctgtcacaag aggaggtcag gcatcaccag     1800

gacacctggc tagccatgcc catctgcaga ctgcgcttca tccccaagcc caacggcctg     1860

cggcccattg tgaacatgag ttatagcatg ggtaccagag ctttgggcag aaggaagcag     1920

gcccagcatt tcacccagcg tctcaagact ctcttcagca tgctcaacta tgagcggaca     1980

aaacatcctc accttatggg gtcttctgta ctgggtatga atgacatcta caggacctgg     2040

cgggcctttg tgctgcgtgt gcgtgctctg gaccagacac ccaggatgta ctttgttaag     2100

gcagatgtga ccggggccta tgatgccatc ccccagggta agctggtgga ggttgttgcc     2160

aatatgatca ggcactcgga gagcacgtac tgtatccgcc agtatgcagt ggtccggaga     2220

gatagccaag gccaagtcca caagtccttt aggagacagg tcaccaccct ctctgacctc     2280

cagccataca tgggccagtt ccttaagcat ctgcaggatt cagatgccag tgcactgagg     2340

aactccgttg tcatcgagca gagcatctct atgaatgaga gcagcagcag cctgtttgac     2400

ttcttcctgc acttcctgcg tcacagtgtc gtaaagattg gtgacaggtg ctatacgcag     2460

tgccagggca tcccccaggg ctccagccta tccaccctgc tctgcagtct gtgtttcgga     2520

gacatggaga acaagctgtt tgctgaggtg cagcgggatg ggttgctttt acgttttgtt     2580

gatgactttc tgttggtgac gcctcacttg gaccaagcaa aaaccttcct cagcaccctg     2640

gtccatggcg ttcctgagta tgggtgcatg ataaacttgc agaagacagt ggtgaacttc     2700

cctgtggagc ctggtaccct gggtggtgca gctccatacc agctgcctgc tcactgcctg     2760

tttccctggt gtggcttgct gctggacact cagactttgg aggtgttctg tgactactca     2820

ggttatgccc agacctcaat taagacgagc ctcaccttcc agagtgtctt caaagctggg     2880

aagaccatgc ggaacaagct cctgtcggtc ttgcggttga agtgtcacgg tctatttcta     2940

gacttgcagg tgaacagcct ccagacagtc tgcatcaata tatacaagat cttcctgctt     3000

caggcctaca ggttccatgc atgtgtgatt cagcttccct ttgaccagcg tgttaggaag     3060

aacctcacat tctttctggg catcatctcc agccaagcat cctgctgcta tgctatcctg     3120

aaggtcaaga atccaggaat gacactaaag gcctctggct cctttcctcc tgaagccgca     3180

cattggctct gctaccaggc cttcctgctc aagctggctg ctcattctgt catctacaaa     3240

tgtctcctgg gacctctgag gacagcccaa aaactgctgt gccggaagct cccagaggcg     3300

acaatgacca tccttaaagc tgcagctgac ccagccctaa gcacagactt tcagaccatt     3360

ttggactaac cctgtctcct tccgctagat gaacatgggc attgtagcct cagcactcct     3420

ggatccacgt cacaagaggg actggtcagt tgtgaggcta ggtcatcctc caaacctctg     3480

tgtcatgggt ggtatgggag attgtcccag tgccttgttt cctgtaacag gcttgatttc     3540

tttcctgatg ccctcaggga ggcagatcct atccctttta gtggcaggga tccactagca     3600

ccagcacatg aggagtgcac ccagtgcaca tgggcactgg gacagtggac aggtgtgaga     3660

ttcctgggcc ctggagtctt ttcacaccta accatggagc ctgtcccagt acatcagagt     3720

gcctcggaga tgaaaaagga catcgagcca gtgacctaaa ttacagcctg aatatactct     3780

gaattc                                                                3786


<210> 2
<211> 3369
<212> DNA
<213> Artificial sequence


<220> 
<223> mTERT CDS

<400> 2
atgacccgcg ctcctcgttg ccccgcggtg cgctctctgc tgcgcagccg ataccgggag       60

gtgtggccgc tggcaacctt tgtgcggcgc ctggggcccg agggcaggcg gcttgtgcaa      120

cccggggacc cgaagatcta ccgcactttg gttgcccaat gcctagtgtg catgcactgg      180

ggctcacagc ctccacctgc cgacctttcc ttccaccagg tgtcatccct gaaagagctg      240

gtggccaggg ttgtgcagag actctgcgag cgcaacgaga gaaacgtgct ggcttttggc      300

tttgagctgc ttaacgaggc cagaggcggg cctcccatgg ccttcactag tagcgtgcgt      360

agctacttgc ccaacactgt tattgagacc ctgcgtgtca gtggtgcatg gatgctactg      420

ttgagccgag tgggcgacga cctgctggtc tacctgctgg cacactgtgc tctttatctt      480

ctggtgcccc ccagctgtgc ctaccaggtg tgtgggtctc ccctgtacca aatttgtgcc      540

accacggata tctggccctc tgtgtccgct agttacaggc ccacccgacc cgtgggcagg      600

aatttcacta accttaggtt cttacaacag atcaagagca gtagtcgcca ggaagcaccg      660

aaacccctgg ccttgccatc tcgaggtaca aagaggcatc tgagtctcac cagtacaagt      720

gtgccttcag ctaagaaggc cagatgctat cctgtcccga gagtggagga gggaccccac      780

aggcaggtgc taccaacccc atcaggcaaa tcatgggtgc caagtcctgc tcggtccccc      840

gaggtgccta ctgcagagaa agatttgtct tctaaaggaa aggtgtctga cctgagtctc      900

tctgggtcgg tgtgctgtaa acacaagccc agctccacat ctctgctgtc accaccccgc      960

caaaatgcct ttcagctcag gccatttatt gagaccagac atttccttta ctccagggga     1020

gatggccaag agcgtctaaa cccctcattc ctactcagca acctccagcc taacttgact     1080

ggggccagga gactggtgga gatcatcttt ctgggctcaa ggcctaggac atcaggacca     1140

ctctgcagga cacaccgtct atcgcgtcga tactggcaga tgcggcccct gttccaacag     1200

ctgctggtga accatgcaga gtgccaatat gtcagactcc tcaggtcaca ttgcaggttt     1260

cgaacagcaa accaacaggt gacagatgcc ttgaacacca gcccaccgca cctcatggat     1320

ttgctccgcc tgcacagcag tccctggcag gtatatggtt ttcttcgggc ctgtctctgc     1380

aaggtggtgt ctgctagtct ctggggtacc aggcacaatg agcgccgctt ctttaagaac     1440

ttaaagaagt tcatctcgtt ggggaaatac ggcaagctat cactgcagga actgatgtgg     1500

aagatgaaag tagaggattg ccactggctc cgcagcagcc cggggaagga ccgtgtcccc     1560

gctgcagagc accgtctgag ggagaggatc ctggctacgt tcctgttctg gctgatggac     1620

acatacgtgg tacagctgct taggtcattc ttttacatca cagagagcac attccagaag     1680

aacaggctct tcttctaccg taagagtgtg tggagcaagc tgcagagcat tggagtcagg     1740

caacaccttg agagagtgcg gctacgggag ctgtcacaag aggaggtcag gcatcaccag     1800

gacacctggc tagccatgcc catctgcaga ctgcgcttca tccccaagcc caacggcctg     1860

cggcccattg tgaacatgag ttatagcatg ggtaccagag ctttgggcag aaggaagcag     1920

gcccagcatt tcacccagcg tctcaagact ctcttcagca tgctcaacta tgagcggaca     1980

aaacatcctc accttatggg gtcttctgta ctgggtatga atgacatcta caggacctgg     2040

cgggcctttg tgctgcgtgt gcgtgctctg gaccagacac ccaggatgta ctttgttaag     2100

gcagatgtga ccggggccta tgatgccatc ccccagggta agctggtgga ggttgttgcc     2160

aatatgatca ggcactcgga gagcacgtac tgtatccgcc agtatgcagt ggtccggaga     2220

gatagccaag gccaagtcca caagtccttt aggagacagg tcaccaccct ctctgacctc     2280

cagccataca tgggccagtt ccttaagcat ctgcaggatt cagatgccag tgcactgagg     2340

aactccgttg tcatcgagca gagcatctct atgaatgaga gcagcagcag cctgtttgac     2400

ttcttcctgc acttcctgcg tcacagtgtc gtaaagattg gtgacaggtg ctatacgcag     2460

tgccagggca tcccccaggg ctccagccta tccaccctgc tctgcagtct gtgtttcgga     2520

gacatggaga acaagctgtt tgctgaggtg cagcgggatg ggttgctttt acgttttgtt     2580

gatgactttc tgttggtgac gcctcacttg gaccaagcaa aaaccttcct cagcaccctg     2640

gtccatggcg ttcctgagta tgggtgcatg ataaacttgc agaagacagt ggtgaacttc     2700

cctgtggagc ctggtaccct gggtggtgca gctccatacc agctgcctgc tcactgcctg     2760

tttccctggt gtggcttgct gctggacact cagactttgg aggtgttctg tgactactca     2820

ggttatgccc agacctcaat taagacgagc ctcaccttcc agagtgtctt caaagctggg     2880

aagaccatgc ggaacaagct cctgtcggtc ttgcggttga agtgtcacgg tctatttcta     2940

gacttgcagg tgaacagcct ccagacagtc tgcatcaata tatacaagat cttcctgctt     3000

caggcctaca ggttccatgc atgtgtgatt cagcttccct ttgaccagcg tgttaggaag     3060

aacctcacat tctttctggg catcatctcc agccaagcat cctgctgcta tgctatcctg     3120

aaggtcaaga atccaggaat gacactaaag gcctctggct cctttcctcc tgaagccgca     3180

cattggctct gctaccaggc cttcctgctc aagctggctg ctcattctgt catctacaaa     3240

tgtctcctgg gacctctgag gacagcccaa aaactgctgt gccggaagct cccagaggcg     3300

acaatgacca tccttaaagc tgcagctgac ccagccctaa gcacagactt tcagaccatt     3360

ttggactaa                                                             3369


<210> 3
<211> 3369
<212> DNA
<213> Artificial sequence


<220> 
<223> moTERT

<400> 3
atgacaagag cccctagatg tcctgccgtc agaagcctgc tgagaagcag atacagagaa       60

gtgtggcccc tggccacctt cgtcagaagg cttggacctg aaggcagacg gctggttcaa      120

cctggcgacc ccaagatcta cagaaccctg gtggctcagt gcctcgtgtg tatgcactgg      180

ggatctcagc cacctcctgc cgatctgagc tttcaccagg tgtccagcct gaaagaactg      240

gtggccagag tggtgcagag actgtgcgag agaaacgaga ggaacgtgct ggccttcggc      300

ttcgagctgc tgaatgaagc tagaggcggc cctcctatgg ccttcacatc tagcgtgcgg      360

agctacctgc ctaacaccgt gatcgagaca ctgagagtgt ccggcgcttg gatgctgctg      420

ctgagcagag tgggagatga cctgctggtg tacctgctgg ctcactgtgc cctctatctg      480

ctggtgcctc ctagctgcgc ttaccaagtg tgcggaagcc ctctgtacca gatctgtgcc      540

accaccgaca tctggcctag cgtgtccgct tcctacagac ccacaagacc cgtgggcaga      600

aactttacca acctgagatt cctgcagcag atcaagagca gctccaggca agaggcccct      660

aagcctcttg ctctgcctag cagaggcacc aagagacacc tgagcctgac cagcacaagc      720

gtgccctctg ccaagaaagc cagatgctac cccgtgccta gagtggaaga gggcccacat      780

agacaggtgc tgcctacacc tagcggcaag agctgggttc catctcctgc tagaagccct      840

gaggtgccaa cagccgagaa ggacctgagc agcaagggca aagtgtccga cctgtctctg      900

agcggcagcg tgtgttgcaa gcacaagcct agcagcacca gcctgctgtc cccacctaga      960

cagaacgctt tccagctgag gccctttatc gagacaagac acttcctgta cagcagaggc     1020

gacggccaag agagactgaa ccctagcttc ctgctgtcta acctgcagcc taacctgacc     1080

ggcgctagaa ggctggtgga aatcatcttc ctgggcagca gacccagaac cagcggacct     1140

ctgtgtagaa cccacagact gagcagacgg tactggcaga tgaggcccct gttccagcag     1200

ctcctggtca accatgccga gtgtcagtat gtgcggctgc tgaggtccca ctgcagattc     1260

agaaccgcca accagcaagt gacagacgcc ctgaacacaa gccctccaca cctgatggat     1320

ctgctgagac tgcacagcag cccctggcag gtctacggct ttctgagagc ctgtctgtgc     1380

aaggtggtgt ccgcatctct gtggggcacc agacacaacg agagaagatt cttcaagaac     1440

ctgaagaagt tcatcagcct ggggaagtac ggcaagctgt ccctgcaaga actgatgtgg     1500

aagatgaagg tcgaggactg ccactggctg aggtctagcc ctggcaagga tagagtgcct     1560

gccgctgagc acaggctgag agagagaatc ctggccacat tcctgttctg gctgatggac     1620

acctacgtgg tgcagctgct gcggagcttc ttctacatca ccgagagcac cttccagaag     1680

aaccggctgt tcttctaccg caagagcgtg tggtccaagc tgcagagcat cggcgtcaga     1740

cagcacctgg aaagagtgcg cctgagagag ctgagccaag aggaagtgcg gcaccaccag     1800

gatacctggc tggccatgcc tatctgcaga ctgagattca tccccaagcc taacggcctg     1860

aggcctatcg tgaacatgag ctacagcatg ggcactagag ccctgggcag aagaaagcag     1920

gcccagcact tcacccagag gctgaaaacc ctgttctcca tgctgaacta cgagcggaca     1980

aagcaccctc atctgatggg ctcctctgtg ctgggcatga acgacatcta caggacctgg     2040

cgggccttcg tgctgagagt cagagcactg gaccagacac ctagaatgta cttcgtgaag     2100

gccgacgtga caggcgccta cgatgctatc cctcagggca aactggtgga agtggtggcc     2160

aacatgatca ggcacagcga gtccacctac tgcatcagac agtacgccgt cgtgcggaga     2220

gactctcagg gacaagtgca caagagcttc cgcagacaag tgaccacact gagcgatctg     2280

cagccctaca tgggccagtt tctgaagcac ctccaggaca gcgacgccag cgctctgaga     2340

aactctgtgg tcatcgagca gtccatctcc atgaacgagt ccagctccag cctgttcgac     2400

ttcttcctgc acttcctgcg gcacagcgtg gtcaagatcg gcgacagatg ttacacccag     2460

tgccagggca tcccacaggg aagcagtctg agcacactgc tgtgctccct gtgtttcggc     2520

gacatggaaa acaagctgtt cgccgaagtg cagcgcgacg gactgctcct gagatttgtg     2580

gacgacttcc tgctcgtgac ccctcacctg gatcaggcta agaccttcct gagcaccctg     2640

gtgcatggcg tgccagagta cggctgcatg atcaacctgc agaaaaccgt ggtcaacttc     2700

cccgtggaac ctggcactct tggaggcgct gctccttatc agctgcccgc tcattgtctg     2760

ttcccttggt gcggactgct gctggacaca cagaccctgg aagtgttctg cgactacagc     2820

ggctacgccc agaccagcat caagaccagc ctgaccttcc agtccgtgtt caaggccggc     2880

aagaccatga ggaacaagct gctgagtgtg ctgaggctga agtgccacgg cctgtttctg     2940

gacctgcaag tgaacagcct gcagaccgtg tgcatcaata tctacaagat ctttctgctg     3000

caagcctacc ggttccacgc ctgtgtgatt cagctgcctt tcgaccagag agtgcggaag     3060

aatctgacat tctttctggg catcatcagc agccaggcca gctgctgtta cgccatcctg     3120

aaagtgaaga accccggcat gaccctgaag gcctctggca gctttccacc tgaagctgcc     3180

cattggctgt gctaccaggc tttcctgctg aaactggctg cccacagcgt gatctacaag     3240

tgcctgctgg gcccactgag aacagcccag aaactgctgt gtcggaagct gcctgaagcc     3300

acaatgacaa tcctgaaggc tgccgccgat ccagctctga gcaccgactt ccagaccatc     3360

ctggactga                                                             3369


<210> 4
<211> 1122
<212> PRT
<213> Mus musculus


<220> 
<223> mTERT protein

<400> 4
Met Thr Arg Ala Pro Arg Cys Pro Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      
Arg Tyr Arg Glu Val Trp Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          
Pro Glu Gly Arg Arg Leu Val Gln Pro Gly Asp Pro Lys Ile Tyr Arg 
        35                  40                  45              
Thr Leu Val Ala Gln Cys Leu Val Cys Met His Trp Gly Ser Gln Pro 
    50                  55                  60                  
Pro Pro Ala Asp Leu Ser Phe His Gln Val Ser Ser Leu Lys Glu Leu 
65                  70                  75                  80  
Val Ala Arg Val Val Gln Arg Leu Cys Glu Arg Asn Glu Arg Asn Val 
                85                  90                  95      
Leu Ala Phe Gly Phe Glu Leu Leu Asn Glu Ala Arg Gly Gly Pro Pro 
            100                 105                 110         
Met Ala Phe Thr Ser Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Ile 
        115                 120                 125             
Glu Thr Leu Arg Val Ser Gly Ala Trp Met Leu Leu Leu Ser Arg Val 
    130                 135                 140                 
Gly Asp Asp Leu Leu Val Tyr Leu Leu Ala His Cys Ala Leu Tyr Leu 
145                 150                 155                 160 
Leu Val Pro Pro Ser Cys Ala Tyr Gln Val Cys Gly Ser Pro Leu Tyr 
                165                 170                 175     
Gln Ile Cys Ala Thr Thr Asp Ile Trp Pro Ser Val Ser Ala Ser Tyr 
            180                 185                 190         
Arg Pro Thr Arg Pro Val Gly Arg Asn Phe Thr Asn Leu Arg Phe Leu 
        195                 200                 205             
Gln Gln Ile Lys Ser Ser Ser Arg Gln Glu Ala Pro Lys Pro Leu Ala 
    210                 215                 220                 
Leu Pro Ser Arg Gly Thr Lys Arg His Leu Ser Leu Thr Ser Thr Ser 
225                 230                 235                 240 
Val Pro Ser Ala Lys Lys Ala Arg Cys Tyr Pro Val Pro Arg Val Glu 
                245                 250                 255     
Glu Gly Pro His Arg Gln Val Leu Pro Thr Pro Ser Gly Lys Ser Trp 
            260                 265                 270         
Val Pro Ser Pro Ala Arg Ser Pro Glu Val Pro Thr Ala Glu Lys Asp 
        275                 280                 285             
Leu Ser Ser Lys Gly Lys Val Ser Asp Leu Ser Leu Ser Gly Ser Val 
    290                 295                 300                 
Cys Cys Lys His Lys Pro Ser Ser Thr Ser Leu Leu Ser Pro Pro Arg 
305                 310                 315                 320 
Gln Asn Ala Phe Gln Leu Arg Pro Phe Ile Glu Thr Arg His Phe Leu 
                325                 330                 335     
Tyr Ser Arg Gly Asp Gly Gln Glu Arg Leu Asn Pro Ser Phe Leu Leu 
            340                 345                 350         
Ser Asn Leu Gln Pro Asn Leu Thr Gly Ala Arg Arg Leu Val Glu Ile 
        355                 360                 365             
Ile Phe Leu Gly Ser Arg Pro Arg Thr Ser Gly Pro Leu Cys Arg Thr 
    370                 375                 380                 
His Arg Leu Ser Arg Arg Tyr Trp Gln Met Arg Pro Leu Phe Gln Gln 
385                 390                 395                 400 
Leu Leu Val Asn His Ala Glu Cys Gln Tyr Val Arg Leu Leu Arg Ser 
                405                 410                 415     
His Cys Arg Phe Arg Thr Ala Asn Gln Gln Val Thr Asp Ala Leu Asn 
            420                 425                 430         
Thr Ser Pro Pro His Leu Met Asp Leu Leu Arg Leu His Ser Ser Pro 
        435                 440                 445             
Trp Gln Val Tyr Gly Phe Leu Arg Ala Cys Leu Cys Lys Val Val Ser 
    450                 455                 460                 
Ala Ser Leu Trp Gly Thr Arg His Asn Glu Arg Arg Phe Phe Lys Asn 
465                 470                 475                 480 
Leu Lys Lys Phe Ile Ser Leu Gly Lys Tyr Gly Lys Leu Ser Leu Gln 
                485                 490                 495     
Glu Leu Met Trp Lys Met Lys Val Glu Asp Cys His Trp Leu Arg Ser 
            500                 505                 510         
Ser Pro Gly Lys Asp Arg Val Pro Ala Ala Glu His Arg Leu Arg Glu 
        515                 520                 525             
Arg Ile Leu Ala Thr Phe Leu Phe Trp Leu Met Asp Thr Tyr Val Val 
    530                 535                 540                 
Gln Leu Leu Arg Ser Phe Phe Tyr Ile Thr Glu Ser Thr Phe Gln Lys 
545                 550                 555                 560 
Asn Arg Leu Phe Phe Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser 
                565                 570                 575     
Ile Gly Val Arg Gln His Leu Glu Arg Val Arg Leu Arg Glu Leu Ser 
            580                 585                 590         
Gln Glu Glu Val Arg His His Gln Asp Thr Trp Leu Ala Met Pro Ile 
        595                 600                 605             
Cys Arg Leu Arg Phe Ile Pro Lys Pro Asn Gly Leu Arg Pro Ile Val 
    610                 615                 620                 
Asn Met Ser Tyr Ser Met Gly Thr Arg Ala Leu Gly Arg Arg Lys Gln 
625                 630                 635                 640 
Ala Gln His Phe Thr Gln Arg Leu Lys Thr Leu Phe Ser Met Leu Asn 
                645                 650                 655     
Tyr Glu Arg Thr Lys His Pro His Leu Met Gly Ser Ser Val Leu Gly 
            660                 665                 670         
Met Asn Asp Ile Tyr Arg Thr Trp Arg Ala Phe Val Leu Arg Val Arg 
        675                 680                 685             
Ala Leu Asp Gln Thr Pro Arg Met Tyr Phe Val Lys Ala Asp Val Thr 
    690                 695                 700                 
Gly Ala Tyr Asp Ala Ile Pro Gln Gly Lys Leu Val Glu Val Val Ala 
705                 710                 715                 720 
Asn Met Ile Arg His Ser Glu Ser Thr Tyr Cys Ile Arg Gln Tyr Ala 
                725                 730                 735     
Val Val Arg Arg Asp Ser Gln Gly Gln Val His Lys Ser Phe Arg Arg 
            740                 745                 750         
Gln Val Thr Thr Leu Ser Asp Leu Gln Pro Tyr Met Gly Gln Phe Leu 
        755                 760                 765             
Lys His Leu Gln Asp Ser Asp Ala Ser Ala Leu Arg Asn Ser Val Val 
    770                 775                 780                 
Ile Glu Gln Ser Ile Ser Met Asn Glu Ser Ser Ser Ser Leu Phe Asp 
785                 790                 795                 800 
Phe Phe Leu His Phe Leu Arg His Ser Val Val Lys Ile Gly Asp Arg 
                805                 810                 815     
Cys Tyr Thr Gln Cys Gln Gly Ile Pro Gln Gly Ser Ser Leu Ser Thr 
            820                 825                 830         
Leu Leu Cys Ser Leu Cys Phe Gly Asp Met Glu Asn Lys Leu Phe Ala 
        835                 840                 845             
Glu Val Gln Arg Asp Gly Leu Leu Leu Arg Phe Val Asp Asp Phe Leu 
    850                 855                 860                 
Leu Val Thr Pro His Leu Asp Gln Ala Lys Thr Phe Leu Ser Thr Leu 
865                 870                 875                 880 
Val His Gly Val Pro Glu Tyr Gly Cys Met Ile Asn Leu Gln Lys Thr 
                885                 890                 895     
Val Val Asn Phe Pro Val Glu Pro Gly Thr Leu Gly Gly Ala Ala Pro 
            900                 905                 910         
Tyr Gln Leu Pro Ala His Cys Leu Phe Pro Trp Cys Gly Leu Leu Leu 
        915                 920                 925             
Asp Thr Gln Thr Leu Glu Val Phe Cys Asp Tyr Ser Gly Tyr Ala Gln 
    930                 935                 940                 
Thr Ser Ile Lys Thr Ser Leu Thr Phe Gln Ser Val Phe Lys Ala Gly 
945                 950                 955                 960 
Lys Thr Met Arg Asn Lys Leu Leu Ser Val Leu Arg Leu Lys Cys His 
                965                 970                 975     
Gly Leu Phe Leu Asp Leu Gln Val Asn Ser Leu Gln Thr Val Cys Ile 
            980                 985                 990         
Asn Ile Tyr Lys Ile Phe Leu Leu Gln Ala Tyr Arg Phe His Ala Cys 
        995                 1000                1005            
Val Ile Gln Leu Pro Phe Asp Gln Arg Val Arg Lys Asn Leu Thr Phe 
    1010                1015                1020                
Phe Leu Gly Ile Ile Ser Ser Gln Ala Ser Cys Cys Tyr Ala Ile Leu 
1025                1030                1035                1040
Lys Val Lys Asn Pro Gly Met Thr Leu Lys Ala Ser Gly Ser Phe Pro 
                1045                1050                1055    
Pro Glu Ala Ala His Trp Leu Cys Tyr Gln Ala Phe Leu Leu Lys Leu 
            1060                1065                1070        
Ala Ala His Ser Val Ile Tyr Lys Cys Leu Leu Gly Pro Leu Arg Thr 
        1075                1080                1085            
Ala Gln Lys Leu Leu Cys Arg Lys Leu Pro Glu Ala Thr Met Thr Ile 
    1090                1095                1100                
Leu Lys Ala Ala Ala Asp Pro Ala Leu Ser Thr Asp Phe Gln Thr Ile 
1105                1110                1115                1120
Leu Asp 
        

<210> 5
<211> 3399
<212> DNA
<213> Homo sapiens


<220> 
<223> hTERT long isoform

<400> 5
atgccgcgcg ctccccgctg ccgagccgtg cgctccctgc tgcgcagcca ctaccgcgag       60

gtgctgccgc tggccacgtt cgtgcggcgc ctggggcccc agggctggcg gctggtgcag      120

cgcggggacc cggcggcttt ccgcgcgctg gtggcccagt gcctggtgtg cgtgccctgg      180

gacgcacggc cgccccccgc cgccccctcc ttccgccagg tgtcctgcct gaaggagctg      240

gtggcccgag tgctgcagag gctgtgcgag cgcggcgcga agaacgtgct ggccttcggc      300

ttcgcgctgc tggacggggc ccgcgggggc ccccccgagg ccttcaccac cagcgtgcgc      360

agctacctgc ccaacacggt gaccgacgca ctgcggggga gcggggcgtg ggggctgctg      420

ctgcgccgcg tgggcgacga cgtgctggtt cacctgctgg cacgctgcgc gctctttgtg      480

ctggtggctc ccagctgcgc ctaccaggtg tgcgggccgc cgctgtacca gctcggcgct      540

gccactcagg cccggccccc gccacacgct agtggacccc gaaggcgtct gggatgcgaa      600

cgggcctgga accatagcgt cagggaggcc ggggtccccc tgggcctgcc agccccgggt      660

gcgaggaggc gcgggggcag tgccagccga agtctgccgt tgcccaagag gcccaggcgt      720

ggcgctgccc ctgagccgga gcggacgccc gttgggcagg ggtcctgggc ccacccgggc      780

aggacgcgtg gaccgagtga ccgtggtttc tgtgtggtgt cacctgccag acccgccgaa      840

gaagccacct ctttggaggg tgcgctctct ggcacgcgcc actcccaccc atccgtgggc      900

cgccagcacc acgcgggccc cccatccaca tcgcggccac cacgtccctg ggacacgcct      960

tgtcccccgg tgtacgccga gaccaagcac ttcctctact cctcaggcga caaggagcag     1020

ctgcggccct ccttcctact cagctctctg aggcccagcc tgactggcgc tcggaggctc     1080

gtggagacca tctttctggg ttccaggccc tggatgccag ggactccccg caggttgccc     1140

cgcctgcccc agcgctactg gcaaatgcgg cccctgtttc tggagctgct tgggaaccac     1200

gcgcagtgcc cctacggggt gctcctcaag acgcactgcc cgctgcgagc tgcggtcacc     1260

ccagcagccg gtgtctgtgc ccgggagaag ccccagggct ctgtggcggc ccccgaggag     1320

gaggacacag acccccgtcg cctggtgcag ctgctccgcc agcacagcag cccctggcag     1380

gtgtacggct tcgtgcgggc ctgcctgcgc cggctggtgc ccccaggcct ctggggctcc     1440

aggcacaacg aacgccgctt cctcaggaac accaagaagt tcatctccct ggggaagcat     1500

gccaagctct cgctgcagga gctgacgtgg aagatgagcg tgcgggactg cgcttggctg     1560

cgcaggagcc caggggttgg ctgtgttccg gccgcagagc accgtctgcg tgaggagatc     1620

ctggccaagt tcctgcactg gctgatgagt gtgtacgtcg tcgagctgct caggtctttc     1680

ttttatgtca cggagaccac gtttcaaaag aacaggctct ttttctaccg gaagagtgtc     1740

tggagcaagt tgcaaagcat tggaatcaga cagcacttga agagggtgca gctgcgggag     1800

ctgtcggaag cagaggtcag gcagcatcgg gaagccaggc ccgccctgct gacgtccaga     1860

ctccgcttca tccccaagcc tgacgggctg cggccgattg tgaacatgga ctacgtcgtg     1920

ggagccagaa cgttccgcag agaaaagagg gccgagcgtc tcacctcgag ggtgaaggca     1980

ctgttcagcg tgctcaacta cgagcgggcg cggcgccccg gcctcctggg cgcctctgtg     2040

ctgggcctgg acgatatcca cagggcctgg cgcaccttcg tgctgcgtgt gcgggcccag     2100

gacccgccgc ctgagctgta ctttgtcaag gtggatgtga cgggcgcgta cgacaccatc     2160

ccccaggaca ggctcacgga ggtcatcgcc agcatcatca aaccccagaa cacgtactgc     2220

gtgcgtcggt atgccgtggt ccagaaggcc gcccatgggc acgtccgcaa ggccttcaag     2280

agccacgtct ctaccttgac agacctccag ccgtacatgc gacagttcgt ggctcacctg     2340

caggagacca gcccgctgag ggatgccgtc gtcatcgagc agagctcctc cctgaatgag     2400

gccagcagtg gcctcttcga cgtcttccta cgcttcatgt gccaccacgc cgtgcgcatc     2460

aggggcaagt cctacgtcca gtgccagggg atcccgcagg gctccatcct ctccacgctg     2520

ctctgcagcc tgtgctacgg cgacatggag aacaagctgt ttgcggggat tcggcgggac     2580

gggctgctcc tgcgtttggt ggatgatttc ttgttggtga cacctcacct cacccacgcg     2640

aaaaccttcc tcaggaccct ggtccgaggt gtccctgagt atggctgcgt ggtgaacttg     2700

cggaagacag tggtgaactt ccctgtagaa gacgaggccc tgggtggcac ggcttttgtt     2760

cagatgccgg cccacggcct attcccctgg tgcggcctgc tgctggatac ccggaccctg     2820

gaggtgcaga gcgactactc cagctatgcc cggacctcca tcagagccag tctcaccttc     2880

aaccgcggct tcaaggctgg gaggaacatg cgtcgcaaac tctttggggt cttgcggctg     2940

aagtgtcaca gcctgtttct ggatttgcag gtgaacagcc tccagacggt gtgcaccaac     3000

atctacaaga tcctcctgct gcaggcgtac aggtttcacg catgtgtgct gcagctccca     3060

tttcatcagc aagtttggaa gaaccccaca tttttcctgc gcgtcatctc tgacacggcc     3120

tccctctgct actccatcct gaaagccaag aacgcaggga tgtcgctggg ggccaagggc     3180

gccgccggcc ctctgccctc cgaggccgtg cagtggctgt gccaccaagc attcctgctc     3240

aagctgactc gacaccgtgt cacctacgtg ccactcctgg ggtcactcag gacagcccag     3300

acgcagctga gtcggaagct cccggggacg acgctgactg ccctggaggc cgcagccaac     3360

ccggcactgc cctcagactt caagaccatc ctggactga                            3399


<210> 6
<211> 3399
<212> DNA
<213> Artificial sequence


<220> 
<223> hoTERT long isoform

<400> 6
atgcctagag cacctagatg tagagctgtg cggagcctgc tgcggagcca ctatagagaa       60

gttctgcccc tggccacctt cgtgcgtaga cttggacctc aaggatggcg gctggtgcag      120

agaggcgatc ctgctgcttt tagagccctg gtggcccagt gtctcgtgtg cgttccatgg      180

gatgctagac ctccaccagc tgctcccagc ttcagacagg tgtcctgcct gaaagaactg      240

gtggccagag tgctgcagcg gctgtgtgaa aggggcgcca aaaatgtgct ggccttcggc      300

tttgctctgc tggatggtgc tagaggcgga cctcctgagg cctttacaac aagcgtgcgg      360

agctacctgc ctaacaccgt gacagatgcc ctgagaggat ctggcgcttg gggactgctg      420

ctgagaagag tgggagatga cgtgctggtg catctgctgg ctagatgcgc cctgtttgtg      480

ctggtggctc ctagctgtgc ctaccaagtc tgtggccctc cactgtatca gctgggcgct      540

gctacacagg ctagaccacc tccacatgcc agcggaccta gaagaaggct gggctgcgaa      600

agagcctgga accactctgt tagagaagcc ggcgtgccac tgggattgcc tgcacctggt      660

gcaagaagaa gaggcggcag cgcctctaga tctctgcctc tgcctaagag gcctcggaga      720

ggtgctgctc ctgagcctga gagaacacct gttggccaag gctcttgggc ccatcctggc      780

agaacaagag gccctagcga tagaggcttc tgcgtggtgt ctcctgccag acctgccgag      840

gaagccacat ctcttgaagg cgccctgagc ggcacaagac actctcaccc atctgtgggc      900

agacagcacc atgccggacc tccaagcaca agcagaccac ctagaccttg ggacacccct      960

tgtcctccag tgtacgccga gacaaagcac ttcctgtaca gcagcggcga caaagagcag     1020

ctgaggccta gcttcctgct gtcctctctg aggccatctc tgaccggtgc tcggagactg     1080

gtggaaacca tcttcctggg cagcagacct tggatgcccg gcacacctag aaggctgcct     1140

agactgccac agcggtactg gcaaatgagg cccctgttcc tggaactgct gggcaatcac     1200

gctcagtgcc cttatggcgt gctgctgaaa acccactgtc ctctgagagc cgccgtgaca     1260

ccagcagctg gcgtttgtgc cagagagaag cctcaaggct ctgtggctgc ccctgaggaa     1320

gaggacacag atcctagacg actggtgcag ctcctgcggc agcattctag tccatggcag     1380

gtctacggat tcgtgcgggc ctgtctgaga aggcttgttc ctcctggact gtggggctcc     1440

agacacaacg agcggcggtt tctgcggaac accaagaagt tcatcagcct gggaaagcac     1500

gccaagctga gcctgcaaga gctgacctgg aagatgagcg tgcgggattg tgcatggctg     1560

agaaggtccc caggcgtggg atgtgttcct gccgctgaac acagactgcg ggaagagatc     1620

ctggccaagt tcctgcactg gctgatgtcc gtgtacgtgg tcgaactgct tcggagcttc     1680

ttctacgtga ccgagacaac cttccagaag aaccggctgt tcttctaccg gaagtccgtg     1740

tggtccaagc tgcagagcat cggcattcgg cagcacctga agagagtgca gctgagagag     1800

ctgagcgagg ctgaagtccg gcagcacaga gaagctagac cagctctgct gaccagcagg     1860

ctgagattca tccccaagcc tgatggcctg cggcctatcg tgaacatgga ctatgttgtg     1920

ggcgccagaa cctttcggag agagaagaga gccgagcggc tgacctctag agtgaaggcc     1980

ctgttcagcg tgctgaacta cgagagagcc agaaggcctg gactgctcgg agcctctgtt     2040

ctgggcctcg acgatatcca cagagcttgg cggacctttg tgctgagagt cagagcccag     2100

gatcctccac ctgagctgta cttcgtgaag gtggacgtga ccggcgccta cgacacaatc     2160

cctcaggaca gactgaccga agtgatcgcc agcatcatca agccccagaa cacctactgt     2220

gtgcggagat acgccgtggt gcagaaagcc gctcatggac atgtgcgcaa ggccttcaag     2280

tcccacgtgt ccacactgac cgacctgcag ccttacatga gacagttcgt ggcccatctg     2340

caagagacaa gccctctgag ggatgccgtg gtcatcgaac agagcagcag cctgaatgag     2400

gccagctccg gcctgtttga cgtgttcctc agattcatgt gccaccacgc cgtgcggatc     2460

agaggcaaga gctatgtgca gtgccagggc attccacagg gcagcatcct gagcacactg     2520

ctgtgcagcc tgtgctacgg cgacatggaa aacaagctgt tcgccggcat cagacgcgac     2580

ggcctgcttc tgagactggt cgacgatttc ctgctcgtga cccctcacct gacacacgcc     2640

aagacctttc tgagaacact cgtgcggggc gtgccagagt atggctgtgt ggtcaacctg     2700

agaaagaccg tggtcaactt ccccgtcgag gatgaagccc ttggcggcac agctttcgtg     2760

cagatgcctg ctcacggact gttcccttgg tgcggactgc tcctggacac cagaacactg     2820

gaagtgcaga gcgactacag cagctacgcc cggacatcta tcagagccag cctgaccttc     2880

aaccggggct ttaaggccgg cagaaacatg cggagaaagc tgtttggagt gctgcggctg     2940

aagtgccact ctttgtttct ggacctgcaa gtgaacagcc tgcagaccgt gtgcaccaac     3000

atctacaaga ttctgctgct gcaagcctac cggttccacg cctgtgttct gcagctgccc     3060

ttccaccagc aagtgtggaa gaaccctaca ttcttcctgc gcgtgatcag cgacaccgcc     3120

agcctgtgtt actccatcct gaaggccaag aacgccggca tgtctctggg agctaaaggc     3180

gctgctggac ctctgccttc tgaagcagtg cagtggctct gccaccaggc ctttctgctg     3240

aagctgacca gacacagagt gacctacgtg cccctgctgg gctcactgag aacagctcag     3300

acacagctga gcagaaagct gcctggcaca accctgacag ccctggaagc tgcagcaaac     3360

cctgctctgc ccagcgactt caagaccatc ctggattga                            3399


<210> 7
<211> 1132
<212> PRT
<213> Homo sapiens


<220> 
<223> hTERT long isoform protein

<400> 7
Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      
His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          
Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              
Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  
Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  
Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      
Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         
Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             
Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 
Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 
Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     
Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         
Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             
Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 
Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 
Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     
Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         
Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             
Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 
Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 
Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     
Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         
Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             
Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 
Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 
Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     
Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         
Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             
Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 
Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 
Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     
Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         
Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             
Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 
Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 
Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     
Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         
Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             
His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 
Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 
Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     
Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         
Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             
Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 
Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 
Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     
Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         
Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             
Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 
Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 
Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     
Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         
Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             
Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 
Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 
Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     
Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         
Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             
Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 
Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 
Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     
Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         
Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu Gln 
        995                 1000                1005            
Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln Gln 
    1010                1015                1020                
Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr Ala 
1025                1030                1035                1040
Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser Leu 
                1045                1050                1055    
Gly Ala Lys Gly Ala Ala Gly Pro Leu Pro Ser Glu Ala Val Gln Trp 
            1060                1065                1070        
Leu Cys His Gln Ala Phe Leu Leu Lys Leu Thr Arg His Arg Val Thr 
        1075                1080                1085            
Tyr Val Pro Leu Leu Gly Ser Leu Arg Thr Ala Gln Thr Gln Leu Ser 
    1090                1095                1100                
Arg Lys Leu Pro Gly Thr Thr Leu Thr Ala Leu Glu Ala Ala Ala Asn 
1105                1110                1115                1120
Pro Ala Leu Pro Ser Asp Phe Lys Thr Ile Leu Asp 
                1125                1130        

<210> 8
<211> 3210
<212> DNA
<213> Homo sapiens


<220> 
<223> hTERT short isoform

<400> 8
atgccgcgcg ctccccgctg ccgagccgtg cgctccctgc tgcgcagcca ctaccgcgag       60

gtgctgccgc tggccacgtt cgtgcggcgc ctggggcccc agggctggcg gctggtgcag      120

cgcggggacc cggcggcttt ccgcgcgctg gtggcccagt gcctggtgtg cgtgccctgg      180

gacgcacggc cgccccccgc cgccccctcc ttccgccagg tgtcctgcct gaaggagctg      240

gtggcccgag tgctgcagag gctgtgcgag cgcggcgcga agaacgtgct ggccttcggc      300

ttcgcgctgc tggacggggc ccgcgggggc ccccccgagg ccttcaccac cagcgtgcgc      360

agctacctgc ccaacacggt gaccgacgca ctgcggggga gcggggcgtg ggggctgctg      420

ctgcgccgcg tgggcgacga cgtgctggtt cacctgctgg cacgctgcgc gctctttgtg      480

ctggtggctc ccagctgcgc ctaccaggtg tgcgggccgc cgctgtacca gctcggcgct      540

gccactcagg cccggccccc gccacacgct agtggacccc gaaggcgtct gggatgcgaa      600

cgggcctgga accatagcgt cagggaggcc ggggtccccc tgggcctgcc agccccgggt      660

gcgaggaggc gcgggggcag tgccagccga agtctgccgt tgcccaagag gcccaggcgt      720

ggcgctgccc ctgagccgga gcggacgccc gttgggcagg ggtcctgggc ccacccgggc      780

aggacgcgtg gaccgagtga ccgtggtttc tgtgtggtgt cacctgccag acccgccgaa      840

gaagccacct ctttggaggg tgcgctctct ggcacgcgcc actcccaccc atccgtgggc      900

cgccagcacc acgcgggccc cccatccaca tcgcggccac cacgtccctg ggacacgcct      960

tgtcccccgg tgtacgccga gaccaagcac ttcctctact cctcaggcga caaggagcag     1020

ctgcggccct ccttcctact cagctctctg aggcccagcc tgactggcgc tcggaggctc     1080

gtggagacca tctttctggg ttccaggccc tggatgccag ggactccccg caggttgccc     1140

cgcctgcccc agcgctactg gcaaatgcgg cccctgtttc tggagctgct tgggaaccac     1200

gcgcagtgcc cctacggggt gctcctcaag acgcactgcc cgctgcgagc tgcggtcacc     1260

ccagcagccg gtgtctgtgc ccgggagaag ccccagggct ctgtggcggc ccccgaggag     1320

gaggacacag acccccgtcg cctggtgcag ctgctccgcc agcacagcag cccctggcag     1380

gtgtacggct tcgtgcgggc ctgcctgcgc cggctggtgc ccccaggcct ctggggctcc     1440

aggcacaacg aacgccgctt cctcaggaac accaagaagt tcatctccct ggggaagcat     1500

gccaagctct cgctgcagga gctgacgtgg aagatgagcg tgcgggactg cgcttggctg     1560

cgcaggagcc caggggttgg ctgtgttccg gccgcagagc accgtctgcg tgaggagatc     1620

ctggccaagt tcctgcactg gctgatgagt gtgtacgtcg tcgagctgct caggtctttc     1680

ttttatgtca cggagaccac gtttcaaaag aacaggctct ttttctaccg gaagagtgtc     1740

tggagcaagt tgcaaagcat tggaatcaga cagcacttga agagggtgca gctgcgggag     1800

ctgtcggaag cagaggtcag gcagcatcgg gaagccaggc ccgccctgct gacgtccaga     1860

ctccgcttca tccccaagcc tgacgggctg cggccgattg tgaacatgga ctacgtcgtg     1920

ggagccagaa cgttccgcag agaaaagagg gccgagcgtc tcacctcgag ggtgaaggca     1980

ctgttcagcg tgctcaacta cgagcgggcg cggcgccccg gcctcctggg cgcctctgtg     2040

ctgggcctgg acgatatcca cagggcctgg cgcaccttcg tgctgcgtgt gcgggcccag     2100

gacccgccgc ctgagctgta ctttgtcaag gtggatgtga cgggcgcgta cgacaccatc     2160

ccccaggaca ggctcacgga ggtcatcgcc agcatcatca aaccccagaa cacgtactgc     2220

gtgcgtcggt atgccgtggt ccagaaggcc gcccatgggc acgtccgcaa ggccttcaag     2280

agccacgtct ctaccttgac agacctccag ccgtacatgc gacagttcgt ggctcacctg     2340

caggagacca gcccgctgag ggatgccgtc gtcatcgagc agagctcctc cctgaatgag     2400

gccagcagtg gcctcttcga cgtcttccta cgcttcatgt gccaccacgc cgtgcgcatc     2460

aggggcaagt cctacgtcca gtgccagggg atcccgcagg gctccatcct ctccacgctg     2520

ctctgcagcc tgtgctacgg cgacatggag aacaagctgt ttgcggggat tcggcgggac     2580

gggctgctcc tgcgtttggt ggatgatttc ttgttggtga cacctcacct cacccacgcg     2640

aaaaccttcc tcagctatgc ccggacctcc atcagagcca gtctcacctt caaccgcggc     2700

ttcaaggctg ggaggaacat gcgtcgcaaa ctctttgggg tcttgcggct gaagtgtcac     2760

agcctgtttc tggatttgca ggtgaacagc ctccagacgg tgtgcaccaa catctacaag     2820

atcctcctgc tgcaggcgta caggtttcac gcatgtgtgc tgcagctccc atttcatcag     2880

caagtttgga agaaccccac atttttcctg cgcgtcatct ctgacacggc ctccctctgc     2940

tactccatcc tgaaagccaa gaacgcaggg atgtcgctgg gggccaaggg cgccgccggc     3000

cctctgccct ccgaggccgt gcagtggctg tgccaccaag cattcctgct caagctgact     3060

cgacaccgtg tcacctacgt gccactcctg gggtcactca ggacagccca gacgcagctg     3120

agtcggaagc tcccggggac gacgctgact gccctggagg ccgcagccaa cccggcactg     3180

ccctcagact tcaagaccat cctggactga                                      3210


<210> 9
<211> 3210
<212> DNA
<213> Artificial sequence


<220> 
<223> hoTERT short isoform

<400> 9
atgcctcggg ctcctagatg tagagccgtc agaagcctgc tgcggagcca ctatagagag       60

gtgctgcctc tggccacctt cgtgcgtaga cttggacctc aaggatggcg gctggtgcag      120

agaggcgatc ctgctgcttt tagagccctg gtggcccagt gtctcgtgtg cgttccatgg      180

gatgctagac ctccaccagc tgctcccagc ttcagacagg tgtcctgcct gaaagaactg      240

gtggccaggg tgctgcagag actgtgtgaa aggggcgcca agaacgtgct ggcctttgga      300

tttgctctgc tggatggcgc tagaggcgga cctcctgagg cctttacaac aagcgtgcgg      360

agctacctgc ctaacaccgt gacagatgcc ctgagaggat ctggcgcttg gggactgctg      420

ctgagaagag tgggagatga cgtgctggtg catctgctgg ccagatgcgc tctgtttgtg      480

ctggtggctc ctagctgcgc ctaccaagtt tgtggccctc cactgtatca gctgggcgct      540

gctacacagg ctagaccacc tccacatgcc agcggaccta gaagaaggct gggctgcgaa      600

agagcctgga accactctgt tagagaagcc ggcgtgccac tgggattgcc tgcaccaggt      660

gcaagaagaa gaggcggcag cgcctctaga tctctgcctc tgcctaagag gcctagaaga      720

ggggctgccc ctgagcctga gagaacacct gttggccaag gctcttgggc ccatcctggc      780

agaacaagag gccctagcga tagaggcttc tgcgtggtgt ctcctgccag acctgccgag      840

gaagccacat ctcttgaagg cgccctgagc ggcacaagac actctcaccc atctgtgggc      900

agacagcacc atgccggacc tccaagcaca agcagaccac ctagaccttg ggacacccct      960

tgtcctccag tgtacgccga gacaaagcac ttcctgtaca gcagcggcga caaagagcag     1020

ctgaggccta gcttcctgct gtcctctctg aggccatctc tgaccggtgc tcggagactg     1080

gtggaaacca tcttcctggg cagcagacct tggatgcccg gcacacctag aaggctgcct     1140

agactgccac agcggtactg gcaaatgagg cccctgttcc tggaactgct gggcaatcac     1200

gctcagtgcc cttatggcgt gctgctgaaa acccactgtc ctctgagagc cgccgtgaca     1260

ccagcagctg gcgtttgtgc cagagagaag cctcaaggct ctgtggccgc tcctgaggaa     1320

gaggacacag atcctagacg actggtgcag ctcctgagac agcacagctc tccatggcag     1380

gtctacggat ttgtgcgggc ctgtctgaga aggctcgttc ctcctggact gtggggctcc     1440

agacacaacg agcggcggtt tctgcggaac accaagaagt tcatcagcct gggaaagcac     1500

gccaagctga gcctgcaaga gctgacctgg aagatgagcg tgcgggattg tgcatggctg     1560

agaaggtccc caggcgtggg atgtgttcct gccgctgaac acagactgcg ggaagagatc     1620

ctggccaagt tcctgcactg gctgatgtcc gtgtacgtgg tcgaactgct tcggagcttc     1680

ttctacgtga ccgagacaac cttccagaag aaccggctgt tcttctaccg gaagtccgtg     1740

tggtccaagc tgcagagcat cggcatccgg cagcatctga agagagtgca gctgagagag     1800

ctgagcgaag ccgaagtgcg gcagcacaga gaagctagac cagctctgct gaccagcagg     1860

ctgagattca tccccaagcc tgatggcctg cggcctatcg tgaacatgga ctatgttgtg     1920

ggcgccagaa cctttcggag agagaagaga gccgagcggc tgacctctag agtgaaggcc     1980

ctgttcagcg tgctgaacta cgagagagcc agaaggccag gactgctggg agcctctgtt     2040

ctgggcctcg acgatatcca cagagcttgg cggacctttg tgctgagagt gcgagcccaa     2100

gatcctccac ctgagctgta cttcgtgaag gtggacgtga ccggcgccta cgacacaatc     2160

cctcaggaca gactgaccga agtgatcgcc agcatcatca agccccagaa cacctactgt     2220

gtgcggagat acgccgtggt gcagaaagcc gctcatggac atgtgcgcaa ggccttcaag     2280

tcccacgtgt ccacactgac cgacctgcag ccttacatga gacagttcgt ggcccatctg     2340

caagagacaa gccctctgag ggatgccgtg gtcatcgaac agagcagcag cctgaatgag     2400

gccagctccg gcctgtttga cgtgttcctc agattcatgt gccaccacgc cgtgcggatc     2460

agaggcaaga gctatgtgca gtgccagggc attcctcagg gcagcatcct gagcacactg     2520

ctgtgcagcc tgtgctacgg cgacatggaa aacaagctgt tcgccggcat cagacgcgac     2580

ggcctgcttc tgagactggt cgacgatttc ctgctcgtga cccctcacct gacacacgcc     2640

aagacctttc tgagctacgc ccggacctct atcagagcca gcctgacctt caaccggggc     2700

tttaaggccg gcagaaacat gcggagaaag ctgtttggag tgctgcggct gaagtgccac     2760

tctttgtttc tggacctgca agtgaacagc ctgcagaccg tgtgcaccaa catctacaag     2820

attctgctgc tgcaagccta ccggttccac gcctgtgttc tgcagctgcc ctttcaccag     2880

caagtgtgga agaaccctac attcttcctg cgcgtgatca gcgacaccgc cagcctgtgt     2940

tactccatcc tgaaggccaa aaacgccggc atgagcctgg gagctaaagg cgctgctgga     3000

cctctgcctt ctgaagcagt gcagtggctg tgtcaccagg cctttctgct gaagctgacc     3060

cggcacagag tgacatatgt gcctctgctg ggctccctga gaaccgctca aacacagctg     3120

agcagaaagc tgcctggcac aaccctgaca gccctggaag ctgcagcaaa ccctgctctg     3180

cccagcgact tcaagaccat cctggattga                                      3210


<210> 10
<211> 1069
<212> PRT
<213> Homo sapiens


<220> 
<223> hTERT short isoform protein

<400> 10
Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      
His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          
Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              
Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  
Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  
Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      
Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         
Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             
Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 
Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 
Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     
Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         
Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             
Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 
Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 
Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     
Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         
Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             
Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 
Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 
Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     
Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         
Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             
Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 
Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 
Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     
Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         
Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             
Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 
Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 
Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     
Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         
Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             
Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 
Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 
Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     
Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         
Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             
His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 
Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 
Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     
Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         
Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             
Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 
Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 
Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     
Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         
Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             
Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 
Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 
Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     
Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         
Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             
Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 
Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 
Lys Thr Phe Leu Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                885                 890                 895     
Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            900                 905                 910         
Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val 
        915                 920                 925             
Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu 
    930                 935                 940                 
Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln 
945                 950                 955                 960 
Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr 
                965                 970                 975     
Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser 
            980                 985                 990         
Leu Gly Ala Lys Gly Ala Ala Gly Pro Leu Pro Ser Glu Ala Val Gln 
        995                 1000                1005            
Trp Leu Cys His Gln Ala Phe Leu Leu Lys Leu Thr Arg His Arg Val 
    1010                1015                1020                
Thr Tyr Val Pro Leu Leu Gly Ser Leu Arg Thr Ala Gln Thr Gln Leu 
1025                1030                1035                1040
Ser Arg Lys Leu Pro Gly Thr Thr Leu Thr Ala Leu Glu Ala Ala Ala 
                1045                1050                1055    
Asn Pro Ala Leu Pro Ser Asp Phe Lys Thr Ile Leu Asp 
            1060                1065                

<210> 11
<211> 1597
<212> DNA
<213> Artificial sequence


<220> 
<223> SpB promoter full length

<400> 11
aataacaagc acgtttcagt tccaccttcc tgaggttcta ccaaggtcac tcagttccca      60

gtctttggtt actcattttt acacagtctt ggtggactcc catgatggca gctgtgtttg     120

ttgtactgac aaggacttga ggccaacaga aactacataa atccttgggt aaccttgagt     180

gtggcattag ccaccttgta tctaattctt tttttttttt tttttttgag acagagtgtt     240

acctggccaa catggtgtca ggagactgcc catcccaggg accaggagcc aggacaccct     300

cagctcagtc acatgtttaa tggccacatg tttaatggcc tcacactccc attccagagt     360

gcagcggtgc aatcatggct cactgcagcc gcgacctggt gggctcaagc gatcctcctg     420

ccccagcttt ctgagtagct gggaccagag acatgcacca ccacacaagg ttaatttttt     480

aatttttttg tagttatgga gtcttactat attggccagg ctggtctcaa actccagggc     540

tcaaaggatc ctccctcctc ggcctcccaa agtgccagga ttacaggagt gagccaccac     600

acccagcccc atctcttttc atcatggtac taattcctgc ccgtccaccc acaaaagcac     660

tgtagtgctt cccgagtata gaggcctgtg agcctccact agggagaggg ctcctgcaga     720

gatcagataa attgatcaca atggctgggg tggtggcaat gtgctaatgc tctctttctt     780

ccactcaaga tatcctctgt ctccctcagc ctgtgagctt tttctccagt gtgctctgcc     840

agtgggggcc ctgcctgaga gcccctgcag ctgcagagga cagtttcttt ctgctgaacc     900

atcgcagcta tgccccagcc cctaccctgg aggggtcccc aggggccatg ggcagcacct     960

cctgtatagg gctgtctggg agccactcca gggccacaga aatcttgtct ctgactcagg    1020

gtattttgtt ttctgttttg tgtaaatgct cttctgacta atgcaaacca tgtgtccata    1080

gaaccagaag atttttccag gggaaaaggt aaggaggtgg tgagagtgtc ctgggtctgc    1140

ccttccaggg cttgccctgg gttaagagcc aggcaggaag ctctcaagag cattgctcaa    1200

gagtagaggg ggcctgggag gcccagggag gggatgggag gggaacaccc aggctgcccc    1260

caaccagatg ccctccaccc tcctcaacct ccctcccacg gcctggagag gtgggaccag    1320

gtatggaggc ttgagagccc ctggttggag gaagccacaa gtccaggaac atgggagtct    1380

gggcaggggg caaaggaggc aggaacaggc catcagccag gacaggtggt aaggcaggca    1440

ggagtgttcc tgctgggaaa aggtgggatc aagcacctgg agggctcttc agagcaaaga    1500

caaacactga ggtcgctgcc actcctacag agcccccacg ccccgcccag ctataagggg    1560

ccatgcacca agcagggtac ccaggctgca gaggtgc                             1597


<210> 12
<211> 632
<212> DNA
<213> Artificial sequence


<220> 
<223> SpB promoter shortened

<400> 12
atagggctgt ctgggagcca ctccagggcc acagaaatct tgtctctgac tcagggtatt      60

ttgttttctg ttttgtgtaa atgctcttct gactaatgca aaccatgtgt ccatagaacc     120

agaagatttt tccaggggaa aaggtaagga ggtggtgaga gtgtcctggg tctgcccttc     180

cagggcttgc cctgggttaa gagccaggca ggaagctctc aagagcattg ctcaagagta     240

gagggggcct gggaggccca gggaggggat gggaggggaa cacccaggct gcccccaacc     300

agatgccctc caccctcctc aacctccctc ccacggcctg gagaggtggg accaggtatg     360

gaggcttgag agcccctggt tggaggaagc cacaagtcca ggaacatggg agtctgggca     420

gggggcaaag gaggcaggaa caggccatca gccaggacag gtggtaaggc aggcaggagt     480

gttcctgctg ggaaaaggtg ggatcaagca cctggagggc tcttcagagc aaagacaaac     540

actgaggtcg ctgccactcc tacagagccc ccacgccccg cccagctata aggggccatg     600

caccaagcag ggtacccagg ctgcagaggt gc                                   632


<210> 13
<211> 296
<212> DNA
<213> Artificial sequence


<220> 
<223> MLC2v promoter shortened

<400> 13
gttaacgttt aaacttagac aatggcagga cccagagcac agagcatcgt tcccaggcca     60

ggccccagcc actgtctctt taaccttgaa ggcatttttg ggtctcacgt gtccacccag    120

gcgggtgtcg gactttgaac ggctcttact tcagaagaac ggcatggggt gggggggctt    180

aggtggcctc tgcctcacct acaactgcca aaagtggtca tggggttatt tttaacccca    240

gggaagaggt atttattgtt ccacagcagg ggccggccag caggctcctt gaattc        296


<210> 14
<211> 380
<212> DNA
<213> Artificial sequence


<220> 
<223> CMV enhancer

<400> 14
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc      60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc     240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat     360

tagtcatcgc tattaccatg                                                 380


<210> 15
<211> 676
<212> DNA
<213> Artificial sequence


<220> 
<223> CMVenh-MLC2v promoter

<400> 15
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc      60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc     240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat     360

tagtcatcgc tattaccatg gttaacgttt aaacttagac aatggcagga cccagagcac     420

agagcatcgt tcccaggcca ggccccagcc actgtctctt taaccttgaa ggcatttttg     480

ggtctcacgt gtccacccag gcgggtgtcg gactttgaac ggctcttact tcagaagaac     540

ggcatggggt gggggggctt aggtggcctc tgcctcacct acaactgcca aaagtggtca     600

tggggttatt tttaacccca gggaagaggt atttattgtt ccacagcagg ggccggccag     660

caggctcctt gaattc                                                     676


<210> 16
<211> 544
<212> DNA
<213> Artificial sequence


<220> 
<223> TNT promoter shortened

<400> 16
ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt      60

ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag     120

tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg     180

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac     240

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat     300

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata     360

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca     420

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc     480

tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca ggatctgtcg     540

gcag                                                                  544


<210> 17
<211> 7
<212> RNA
<213> Artificial sequence


<220> 
<223> kozak sequence

<400> 17
accaugg                                                               7


<210> 18
<211> 225
<212> DNA
<213> Artificial sequence


<220> 
<223> BGH polyA

<400> 18
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc    120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt    180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                    225


<210> 19
<211> 141
<212> DNA
<213> Artificial sequence


<220> 
<223> 5' ITR AAV2

<400> 19
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc     60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca    120

actccatcac taggggttcc t                                              141


<210> 20
<211> 141
<212> DNA
<213> Artificial sequence


<220> 
<223> 3' ITR AAV2

<400> 20
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc    120

gagcgcgcag ctgcctgcag g                                              141


<210> 21
<211> 4638
<212> DNA
<213> Artificial sequence


<220> 
<223> AAV-SpB-moTERT recombinant adeno-associated virus genome

<400> 21
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgcg atatcatagg gctgtctggg agccactcca      180

gggccacaga aatcttgtct ctgactcagg gtattttgtt ttctgttttg tgtaaatgct      240

cttctgacta atgcaaacca tgtgtccata gaaccagaag atttttccag gggaaaaggt      300

aaggaggtgg tgagagtgtc ctgggtctgc ccttccaggg cttgccctgg gttaagagcc      360

aggcaggaag ctctcaagag cattgctcaa gagtagaggg ggcctgggag gcccagggag      420

gggatgggag gggaacaccc aggctgcccc caaccagatg ccctccaccc tcctcaacct      480

ccctcccacg gcctggagag gtgggaccag gtatggaggc ttgagagccc ctggttggag      540

gaagccacaa gtccaggaac atgggagtct gggcaggggg caaaggaggc aggaacaggc      600

catcagccag gacaggtggt aaggcaggca ggagtgttcc tgctgggaaa aggtgggatc      660

aagcacctgg agggctcttc agagcaaaga caaacactga ggtcgctgcc actcctacag      720

agcccccacg ccccgcccag ctataagggg ccatgcacca agcagggtac ccaggctgca      780

gaggtgcgaa ttcatttaaa ttctagatcg ctagcacgcg tgccaccatg acaagagccc      840

ctagatgtcc tgccgtcaga agcctgctga gaagcagata cagagaagtg tggcccctgg      900

ccaccttcgt cagaaggctt ggacctgaag gcagacggct ggttcaacct ggcgacccca      960

agatctacag aaccctggtg gctcagtgcc tcgtgtgtat gcactgggga tctcagccac     1020

ctcctgccga tctgagcttt caccaggtgt ccagcctgaa agaactggtg gccagagtgg     1080

tgcagagact gtgcgagaga aacgagagga acgtgctggc cttcggcttc gagctgctga     1140

atgaagctag aggcggccct cctatggcct tcacatctag cgtgcggagc tacctgccta     1200

acaccgtgat cgagacactg agagtgtccg gcgcttggat gctgctgctg agcagagtgg     1260

gagatgacct gctggtgtac ctgctggctc actgtgccct ctatctgctg gtgcctccta     1320

gctgcgctta ccaagtgtgc ggaagccctc tgtaccagat ctgtgccacc accgacatct     1380

ggcctagcgt gtccgcttcc tacagaccca caagacccgt gggcagaaac tttaccaacc     1440

tgagattcct gcagcagatc aagagcagct ccaggcaaga ggcccctaag cctcttgctc     1500

tgcctagcag aggcaccaag agacacctga gcctgaccag cacaagcgtg ccctctgcca     1560

agaaagccag atgctacccc gtgcctagag tggaagaggg cccacataga caggtgctgc     1620

ctacacctag cggcaagagc tgggttccat ctcctgctag aagccctgag gtgccaacag     1680

ccgagaagga cctgagcagc aagggcaaag tgtccgacct gtctctgagc ggcagcgtgt     1740

gttgcaagca caagcctagc agcaccagcc tgctgtcccc acctagacag aacgctttcc     1800

agctgaggcc ctttatcgag acaagacact tcctgtacag cagaggcgac ggccaagaga     1860

gactgaaccc tagcttcctg ctgtctaacc tgcagcctaa cctgaccggc gctagaaggc     1920

tggtggaaat catcttcctg ggcagcagac ccagaaccag cggacctctg tgtagaaccc     1980

acagactgag cagacggtac tggcagatga ggcccctgtt ccagcagctc ctggtcaacc     2040

atgccgagtg tcagtatgtg cggctgctga ggtcccactg cagattcaga accgccaacc     2100

agcaagtgac agacgccctg aacacaagcc ctccacacct gatggatctg ctgagactgc     2160

acagcagccc ctggcaggtc tacggctttc tgagagcctg tctgtgcaag gtggtgtccg     2220

catctctgtg gggcaccaga cacaacgaga gaagattctt caagaacctg aagaagttca     2280

tcagcctggg gaagtacggc aagctgtccc tgcaagaact gatgtggaag atgaaggtcg     2340

aggactgcca ctggctgagg tctagccctg gcaaggatag agtgcctgcc gctgagcaca     2400

ggctgagaga gagaatcctg gccacattcc tgttctggct gatggacacc tacgtggtgc     2460

agctgctgcg gagcttcttc tacatcaccg agagcacctt ccagaagaac cggctgttct     2520

tctaccgcaa gagcgtgtgg tccaagctgc agagcatcgg cgtcagacag cacctggaaa     2580

gagtgcgcct gagagagctg agccaagagg aagtgcggca ccaccaggat acctggctgg     2640

ccatgcctat ctgcagactg agattcatcc ccaagcctaa cggcctgagg cctatcgtga     2700

acatgagcta cagcatgggc actagagccc tgggcagaag aaagcaggcc cagcacttca     2760

cccagaggct gaaaaccctg ttctccatgc tgaactacga gcggacaaag caccctcatc     2820

tgatgggctc ctctgtgctg ggcatgaacg acatctacag gacctggcgg gccttcgtgc     2880

tgagagtcag agcactggac cagacaccta gaatgtactt cgtgaaggcc gacgtgacag     2940

gcgcctacga tgctatccct cagggcaaac tggtggaagt ggtggccaac atgatcaggc     3000

acagcgagtc cacctactgc atcagacagt acgccgtcgt gcggagagac tctcagggac     3060

aagtgcacaa gagcttccgc agacaagtga ccacactgag cgatctgcag ccctacatgg     3120

gccagtttct gaagcacctc caggacagcg acgccagcgc tctgagaaac tctgtggtca     3180

tcgagcagtc catctccatg aacgagtcca gctccagcct gttcgacttc ttcctgcact     3240

tcctgcggca cagcgtggtc aagatcggcg acagatgtta cacccagtgc cagggcatcc     3300

cacagggaag cagtctgagc acactgctgt gctccctgtg tttcggcgac atggaaaaca     3360

agctgttcgc cgaagtgcag cgcgacggac tgctcctgag atttgtggac gacttcctgc     3420

tcgtgacccc tcacctggat caggctaaga ccttcctgag caccctggtg catggcgtgc     3480

cagagtacgg ctgcatgatc aacctgcaga aaaccgtggt caacttcccc gtggaacctg     3540

gcactcttgg aggcgctgct ccttatcagc tgcccgctca ttgtctgttc ccttggtgcg     3600

gactgctgct ggacacacag accctggaag tgttctgcga ctacagcggc tacgcccaga     3660

ccagcatcaa gaccagcctg accttccagt ccgtgttcaa ggccggcaag accatgagga     3720

acaagctgct gagtgtgctg aggctgaagt gccacggcct gtttctggac ctgcaagtga     3780

acagcctgca gaccgtgtgc atcaatatct acaagatctt tctgctgcaa gcctaccggt     3840

tccacgcctg tgtgattcag ctgcctttcg accagagagt gcggaagaat ctgacattct     3900

ttctgggcat catcagcagc caggccagct gctgttacgc catcctgaaa gtgaagaacc     3960

ccggcatgac cctgaaggcc tctggcagct ttccacctga agctgcccat tggctgtgct     4020

accaggcttt cctgctgaaa ctggctgccc acagcgtgat ctacaagtgc ctgctgggcc     4080

cactgagaac agcccagaaa ctgctgtgtc ggaagctgcc tgaagccaca atgacaatcc     4140

tgaaggctgc cgccgatcca gctctgagca ccgacttcca gaccatcctg gactgagaat     4200

tcggatccga ttcgagcatt taaatacgtg gagctcgctg atcagcctcg actgtgcctt     4260

ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg     4320

ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt     4380

gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca     4440

atagcaggca tgctggggat gcggtgggct ctatggccac gtggatatcg cggccgcagg     4500

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     4560

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     4620

cgcgcagctg cctgcagg                                                   4638


<210> 22
<211> 4676
<212> DNA
<213> Artificial sequence


<220> 
<223> AAV9-CMVenh-MLC2v-moTERT

<400> 22
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgcg atatcgacat tgattattga ctagttatta      180

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      240

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      300

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      360

ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      420

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      480

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggttaa      540

cgtttaaact tagacaatgg caggacccag agcacagagc atcgttccca ggccaggccc      600

cagccactgt ctctttaacc ttgaaggcat ttttgggtct cacgtgtcca cccaggcggg      660

tgtcggactt tgaacggctc ttacttcaga agaacggcat ggggtggggg ggcttaggtg      720

gcctctgcct cacctacaac tgccaaaagt ggtcatgggg ttatttttaa ccccagggaa      780

gaggtattta ttgttccaca gcaggggccg gccagcaggc tccttgaatt catttaaatt      840

ctagatcgct agcacgcgtg ccaccatgac aagagcccct agatgtcctg ccgtcagaag      900

cctgctgaga agcagataca gagaagtgtg gcccctggcc accttcgtca gaaggcttgg      960

acctgaaggc agacggctgg ttcaacctgg cgaccccaag atctacagaa ccctggtggc     1020

tcagtgcctc gtgtgtatgc actggggatc tcagccacct cctgccgatc tgagctttca     1080

ccaggtgtcc agcctgaaag aactggtggc cagagtggtg cagagactgt gcgagagaaa     1140

cgagaggaac gtgctggcct tcggcttcga gctgctgaat gaagctagag gcggccctcc     1200

tatggccttc acatctagcg tgcggagcta cctgcctaac accgtgatcg agacactgag     1260

agtgtccggc gcttggatgc tgctgctgag cagagtggga gatgacctgc tggtgtacct     1320

gctggctcac tgtgccctct atctgctggt gcctcctagc tgcgcttacc aagtgtgcgg     1380

aagccctctg taccagatct gtgccaccac cgacatctgg cctagcgtgt ccgcttccta     1440

cagacccaca agacccgtgg gcagaaactt taccaacctg agattcctgc agcagatcaa     1500

gagcagctcc aggcaagagg cccctaagcc tcttgctctg cctagcagag gcaccaagag     1560

acacctgagc ctgaccagca caagcgtgcc ctctgccaag aaagccagat gctaccccgt     1620

gcctagagtg gaagagggcc cacatagaca ggtgctgcct acacctagcg gcaagagctg     1680

ggttccatct cctgctagaa gccctgaggt gccaacagcc gagaaggacc tgagcagcaa     1740

gggcaaagtg tccgacctgt ctctgagcgg cagcgtgtgt tgcaagcaca agcctagcag     1800

caccagcctg ctgtccccac ctagacagaa cgctttccag ctgaggccct ttatcgagac     1860

aagacacttc ctgtacagca gaggcgacgg ccaagagaga ctgaacccta gcttcctgct     1920

gtctaacctg cagcctaacc tgaccggcgc tagaaggctg gtggaaatca tcttcctggg     1980

cagcagaccc agaaccagcg gacctctgtg tagaacccac agactgagca gacggtactg     2040

gcagatgagg cccctgttcc agcagctcct ggtcaaccat gccgagtgtc agtatgtgcg     2100

gctgctgagg tcccactgca gattcagaac cgccaaccag caagtgacag acgccctgaa     2160

cacaagccct ccacacctga tggatctgct gagactgcac agcagcccct ggcaggtcta     2220

cggctttctg agagcctgtc tgtgcaaggt ggtgtccgca tctctgtggg gcaccagaca     2280

caacgagaga agattcttca agaacctgaa gaagttcatc agcctgggga agtacggcaa     2340

gctgtccctg caagaactga tgtggaagat gaaggtcgag gactgccact ggctgaggtc     2400

tagccctggc aaggatagag tgcctgccgc tgagcacagg ctgagagaga gaatcctggc     2460

cacattcctg ttctggctga tggacaccta cgtggtgcag ctgctgcgga gcttcttcta     2520

catcaccgag agcaccttcc agaagaaccg gctgttcttc taccgcaaga gcgtgtggtc     2580

caagctgcag agcatcggcg tcagacagca cctggaaaga gtgcgcctga gagagctgag     2640

ccaagaggaa gtgcggcacc accaggatac ctggctggcc atgcctatct gcagactgag     2700

attcatcccc aagcctaacg gcctgaggcc tatcgtgaac atgagctaca gcatgggcac     2760

tagagccctg ggcagaagaa agcaggccca gcacttcacc cagaggctga aaaccctgtt     2820

ctccatgctg aactacgagc ggacaaagca ccctcatctg atgggctcct ctgtgctggg     2880

catgaacgac atctacagga cctggcgggc cttcgtgctg agagtcagag cactggacca     2940

gacacctaga atgtacttcg tgaaggccga cgtgacaggc gcctacgatg ctatccctca     3000

gggcaaactg gtggaagtgg tggccaacat gatcaggcac agcgagtcca cctactgcat     3060

cagacagtac gccgtcgtgc ggagagactc tcagggacaa gtgcacaaga gcttccgcag     3120

acaagtgacc acactgagcg atctgcagcc ctacatgggc cagtttctga agcacctcca     3180

ggacagcgac gccagcgctc tgagaaactc tgtggtcatc gagcagtcca tctccatgaa     3240

cgagtccagc tccagcctgt tcgacttctt cctgcacttc ctgcggcaca gcgtggtcaa     3300

gatcggcgac agatgttaca cccagtgcca gggcatccca cagggaagca gtctgagcac     3360

actgctgtgc tccctgtgtt tcggcgacat ggaaaacaag ctgttcgccg aagtgcagcg     3420

cgacggactg ctcctgagat ttgtggacga cttcctgctc gtgacccctc acctggatca     3480

ggctaagacc ttcctgagca ccctggtgca tggcgtgcca gagtacggct gcatgatcaa     3540

cctgcagaaa accgtggtca acttccccgt ggaacctggc actcttggag gcgctgctcc     3600

ttatcagctg cccgctcatt gtctgttccc ttggtgcgga ctgctgctgg acacacagac     3660

cctggaagtg ttctgcgact acagcggcta cgcccagacc agcatcaaga ccagcctgac     3720

cttccagtcc gtgttcaagg ccggcaagac catgaggaac aagctgctga gtgtgctgag     3780

gctgaagtgc cacggcctgt ttctggacct gcaagtgaac agcctgcaga ccgtgtgcat     3840

caatatctac aagatctttc tgctgcaagc ctaccggttc cacgcctgtg tgattcagct     3900

gcctttcgac cagagagtgc ggaagaatct gacattcttt ctgggcatca tcagcagcca     3960

ggccagctgc tgttacgcca tcctgaaagt gaagaacccc ggcatgaccc tgaaggcctc     4020

tggcagcttt ccacctgaag ctgcccattg gctgtgctac caggctttcc tgctgaaact     4080

ggctgcccac agcgtgatct acaagtgcct gctgggccca ctgagaacag cccagaaact     4140

gctgtgtcgg aagctgcctg aagccacaat gacaatcctg aaggctgccg ccgatccagc     4200

tctgagcacc gacttccaga ccatcctgga ctgagaattc ggatccgatt cgagcattta     4260

aatacgtgga gctcgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     4320

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     4380

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     4440

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     4500

ggtgggctct atggccacgt ggatatcgcg gccgcaggaa cccctagtga tggagttggc     4560

cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg     4620

cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcagctgcc tgcagg         4676


<210> 23
<211> 4536
<212> DNA
<213> Artificial sequence


<220> 
<223> AAV9-TNT-moTert

<400> 23
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgcg atatcctcag tccattagga gccagtagcc      180

tggaagatgt ctttaccccc agcatcagtt caagtggagc agcacataac tcttgccctc      240

tgccttccaa gattctggtg ctgagactta tggagtgtct tggaggttgc cttctgcccc      300

ccaaccctgc tcccagctgg ccctcccagg cctgggttgc tggcctctgc tttatcagga      360

ttctcaagag ggacagctgg tttatgttgc atgactgttc cctgcatatc tgctctggtt      420

ttaaatagct tatctgagca gctggaggac cacatgggct tatatggcgt ggggtacatg      480

ttcctgtagc cttgtccctg gcacctgcca aaatagcagc caacaccccc cacccccacc      540

gccatccccc tgccccaccc gtcccctgtc gcacattcct ccctccgcag ggctggctca      600

ccaggcccca gcccacatgc ctgcttaaag ccctctccat cctctgcctc acccagtccc      660

cgctgagact gagcagacgc ctccaggatc tgtcggcagg aattatcgct agcacgcgtg      720

ccaccatgac aagagcccct agatgtcctg ccgtcagaag cctgctgaga agcagataca      780

gagaagtgtg gcccctggcc accttcgtca gaaggcttgg acctgaaggc agacggctgg      840

ttcaacctgg cgaccccaag atctacagaa ccctggtggc tcagtgcctc gtgtgtatgc      900

actggggatc tcagccacct cctgccgatc tgagctttca ccaggtgtcc agcctgaaag      960

aactggtggc cagagtggtg cagagactgt gcgagagaaa cgagaggaac gtgctggcct     1020

tcggcttcga gctgctgaat gaagctagag gcggccctcc tatggccttc acatctagcg     1080

tgcggagcta cctgcctaac accgtgatcg agacactgag agtgtccggc gcttggatgc     1140

tgctgctgag cagagtggga gatgacctgc tggtgtacct gctggctcac tgtgccctct     1200

atctgctggt gcctcctagc tgcgcttacc aagtgtgcgg aagccctctg taccagatct     1260

gtgccaccac cgacatctgg cctagcgtgt ccgcttccta cagacccaca agacccgtgg     1320

gcagaaactt taccaacctg agattcctgc agcagatcaa gagcagctcc aggcaagagg     1380

cccctaagcc tcttgctctg cctagcagag gcaccaagag acacctgagc ctgaccagca     1440

caagcgtgcc ctctgccaag aaagccagat gctaccccgt gcctagagtg gaagagggcc     1500

cacatagaca ggtgctgcct acacctagcg gcaagagctg ggttccatct cctgctagaa     1560

gccctgaggt gccaacagcc gagaaggacc tgagcagcaa gggcaaagtg tccgacctgt     1620

ctctgagcgg cagcgtgtgt tgcaagcaca agcctagcag caccagcctg ctgtccccac     1680

ctagacagaa cgctttccag ctgaggccct ttatcgagac aagacacttc ctgtacagca     1740

gaggcgacgg ccaagagaga ctgaacccta gcttcctgct gtctaacctg cagcctaacc     1800

tgaccggcgc tagaaggctg gtggaaatca tcttcctggg cagcagaccc agaaccagcg     1860

gacctctgtg tagaacccac agactgagca gacggtactg gcagatgagg cccctgttcc     1920

agcagctcct ggtcaaccat gccgagtgtc agtatgtgcg gctgctgagg tcccactgca     1980

gattcagaac cgccaaccag caagtgacag acgccctgaa cacaagccct ccacacctga     2040

tggatctgct gagactgcac agcagcccct ggcaggtcta cggctttctg agagcctgtc     2100

tgtgcaaggt ggtgtccgca tctctgtggg gcaccagaca caacgagaga agattcttca     2160

agaacctgaa gaagttcatc agcctgggga agtacggcaa gctgtccctg caagaactga     2220

tgtggaagat gaaggtcgag gactgccact ggctgaggtc tagccctggc aaggatagag     2280

tgcctgccgc tgagcacagg ctgagagaga gaatcctggc cacattcctg ttctggctga     2340

tggacaccta cgtggtgcag ctgctgcgga gcttcttcta catcaccgag agcaccttcc     2400

agaagaaccg gctgttcttc taccgcaaga gcgtgtggtc caagctgcag agcatcggcg     2460

tcagacagca cctggaaaga gtgcgcctga gagagctgag ccaagaggaa gtgcggcacc     2520

accaggatac ctggctggcc atgcctatct gcagactgag attcatcccc aagcctaacg     2580

gcctgaggcc tatcgtgaac atgagctaca gcatgggcac tagagccctg ggcagaagaa     2640

agcaggccca gcacttcacc cagaggctga aaaccctgtt ctccatgctg aactacgagc     2700

ggacaaagca ccctcatctg atgggctcct ctgtgctggg catgaacgac atctacagga     2760

cctggcgggc cttcgtgctg agagtcagag cactggacca gacacctaga atgtacttcg     2820

tgaaggccga cgtgacaggc gcctacgatg ctatccctca gggcaaactg gtggaagtgg     2880

tggccaacat gatcaggcac agcgagtcca cctactgcat cagacagtac gccgtcgtgc     2940

ggagagactc tcagggacaa gtgcacaaga gcttccgcag acaagtgacc acactgagcg     3000

atctgcagcc ctacatgggc cagtttctga agcacctcca ggacagcgac gccagcgctc     3060

tgagaaactc tgtggtcatc gagcagtcca tctccatgaa cgagtccagc tccagcctgt     3120

tcgacttctt cctgcacttc ctgcggcaca gcgtggtcaa gatcggcgac agatgttaca     3180

cccagtgcca gggcatccca cagggaagca gtctgagcac actgctgtgc tccctgtgtt     3240

tcggcgacat ggaaaacaag ctgttcgccg aagtgcagcg cgacggactg ctcctgagat     3300

ttgtggacga cttcctgctc gtgacccctc acctggatca ggctaagacc ttcctgagca     3360

ccctggtgca tggcgtgcca gagtacggct gcatgatcaa cctgcagaaa accgtggtca     3420

acttccccgt ggaacctggc actcttggag gcgctgctcc ttatcagctg cccgctcatt     3480

gtctgttccc ttggtgcgga ctgctgctgg acacacagac cctggaagtg ttctgcgact     3540

acagcggcta cgcccagacc agcatcaaga ccagcctgac cttccagtcc gtgttcaagg     3600

ccggcaagac catgaggaac aagctgctga gtgtgctgag gctgaagtgc cacggcctgt     3660

ttctggacct gcaagtgaac agcctgcaga ccgtgtgcat caatatctac aagatctttc     3720

tgctgcaagc ctaccggttc cacgcctgtg tgattcagct gcctttcgac cagagagtgc     3780

ggaagaatct gacattcttt ctgggcatca tcagcagcca ggccagctgc tgttacgcca     3840

tcctgaaagt gaagaacccc ggcatgaccc tgaaggcctc tggcagcttt ccacctgaag     3900

ctgcccattg gctgtgctac caggctttcc tgctgaaact ggctgcccac agcgtgatct     3960

acaagtgcct gctgggccca ctgagaacag cccagaaact gctgtgtcgg aagctgcctg     4020

aagccacaat gacaatcctg aaggctgccg ccgatccagc tctgagcacc gacttccaga     4080

ccatcctgga ctgagaattc ggatccgatt cgagcattta aatacgtgga gctcgctgat     4140

cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt     4200

ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat     4260

cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg     4320

gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggccacgt     4380

ggatatcgcg gccgcaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     4440

gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg     4500

cctcagtgag cgagcgagcg cgcagctgcc tgcagg                               4536


<210> 24
<211> 2027
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV9-CMV-null genome and AAV6-CMV-null virus genome

<400> 24
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg      60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag     120

gggttcctgc ggccgcacgc gtggagctag ttattaatag taatcaatta cggggtcatt     180

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg     240

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac     300

gtcaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt     360

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa     420

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta     480

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg     540

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg     600

gagtttgttt tgcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca     660

ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta     720

gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac     780

cgggaccgat ccagcctccg cggattcgaa tcccggccgg gaacggtgca ttggaacgcg     840

gattccccgt gccaagagtg acgtaagtac cgcctataga gtctataggc ccacaaaaaa     900

tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt ccctaatctc     960

tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt ctaaagaata    1020

acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat atttctgcat    1080

ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa tccagctacc    1140

attctgcttt tattttatgg ttgggataag gctggattat tctgagtcca agctaggccc    1200

ttttgctaat catgttcata cctcttatct tcctcccaca gctcctgggc aacgtgctgg    1260

tctgtgtgct ggcccatcac tttggcaaag aattgggatt cgaacatcga ttgaattccc    1320

cggggatcct ctagagtcga cctgcagaag cttgcctcga gcagcgctgc tcgagagatc    1380

tacgggtggc atccctgtga cccctcccca gtgcctctcc tggccctgga agttgccact    1440

ccagtgccca ccagccttgt cctaataaaa ttaagttgca tcattttgtc tgactaggtg    1500

tccttctata atattatggg gtggaggggg gtggtatgga gcaaggggca agttgggaag    1560

acaacctgta gggcctgcgg ggtctattgg gaaccaagct ggagtgcagt ggcacaatct    1620

tggctcactg caatctccgc ctcctgggtt caagcgattc tcctgcctca gcctcccgag    1680

ttgttgggat tccaggcatg catgaccagg ctcagctaat ttttgttttt ttggtagaga    1740

cggggtttca ccatattggc caggctggtc tccaactcct aatctcaggt gatctaccca    1800

ccttggcctc ccaaattgct gggattacag gcgtgaacca ctgctccctt ccctgtcctt    1860

ctgattttgt aggtaaccac gtgcggaccg agcggccgca ggaaccccta gtgatggagt    1920

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc    1980

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgc                  2027


<210> 25
<211> 5320
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV9-CMV-mTERT virus genome

<400> 25
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtggagc tagttattaa tagtaatcaa      180

ttacggggtc attagttcat agcccatata tggagttccg cgttacataa cttacggtaa      240

atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg      300

ttcccatagt aacgtcaata gggactttcc attgacgtca atgggtggag tatttacggt      360

aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg      420

tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc      480

ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg cggttttggc      540

agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca      600

ttgacgtcaa tgggagtttg ttttgcacca aaatcaacgg gactttccaa aatgtcgtaa      660

caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      720

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      780

ccatagaaga caccgggacc gatccagcct ccgcggattc gaatcccggc cgggaacggt      840

gcattggaac gcggattccc cgtgccaaga gtgacgtaag taccgcctat agagtctata      900

ggcccacaaa aaatgctttc ttcttttaat atactttttt gtttatctta tttctaatac      960

tttccctaat ctctttcttt cagggcaata atgatacaat gtatcatgcc tctttgcacc     1020

attctaaaga ataacagtga taatttctgg gttaaggcaa tagcaatatt tctgcatata     1080

aatatttctg catataaatt gtaactgatg taagaggttt catattgcta atagcagcta     1140

caatccagct accattctgc ttttatttta tggttgggat aaggctggat tattctgagt     1200

ccaagctagg cccttttgct aatcatgttc atacctctta tcttcctccc acagctcctg     1260

ggcaacgtgc tggtctgtgt gctggcccat cactttggca aagaattggg attcgaacat     1320

cgattgaatt catgacccgc gctcctcgtt gccccgcggt gcgctctctg ctgcgcagcc     1380

gataccggga ggtgtggccg ctggcaacct ttgtgcggcg cctggggccc gagggcaggc     1440

ggcttgtgca acccggggac ccgaagatct accgcacttt ggttgcccaa tgcctagtgt     1500

gcatgcactg gggctcacag cctccacctg ccgacctttc cttccaccag gtgtcatccc     1560

tgaaagagct ggtggccagg gttgtgcaga gactctgcga gcgcaacgag agaaacgtgc     1620

tggcttttgg ctttgagctg cttaacgagg ccagaggcgg gcctcccatg gccttcacta     1680

gtagcgtgcg tagctacttg cccaacactg ttattgagac cctgcgtgtc agtggtgcat     1740

ggatgctact gttgagccga gtgggcgacg acctgctggt ctacctgctg gcacactgtg     1800

ctctttatct tctggtgccc cccagctgtg cctaccaggt gtgtgggtct cccctgtacc     1860

aaatttgtgc caccacggat atctggccct ctgtgtccgc tagttacagg cccacccgac     1920

ccgtgggcag gaatttcact aaccttaggt tcttacaaca gatcaagagc agtagtcgcc     1980

aggaagcacc gaaacccctg gccttgccat ctcgaggtac aaagaggcat ctgagtctca     2040

ccagtacaag tgtgccttca gctaagaagg ccagatgcta tcctgtcccg agagtggagg     2100

agggacccca caggcaggtg ctaccaaccc catcaggcaa atcatgggtg ccaagtcctg     2160

ctcggtcccc cgaggtgcct actgcagaga aagatttgtc ttctaaagga aaggtgtctg     2220

acctgagtct ctctgggtcg gtgtgctgta aacacaagcc cagctccaca tctctgctgt     2280

caccaccccg ccaaaatgcc tttcagctca ggccatttat tgagaccaga catttccttt     2340

actccagggg agatggccaa gagcgtctaa acccctcatt cctactcagc aacctccagc     2400

ctaacttgac tggggccagg agactggtgg agatcatctt tctgggctca aggcctagga     2460

catcaggacc actctgcagg acacaccgtc tatcgcgtcg atactggcag atgcggcccc     2520

tgttccaaca gctgctggtg aaccatgcag agtgccaata tgtcagactc ctcaggtcac     2580

attgcaggtt tcgaacagca aaccaacagg tgacagatgc cttgaacacc agcccaccgc     2640

acctcatgga tttgctccgc ctgcacagca gtccctggca ggtatatggt tttcttcggg     2700

cctgtctctg caaggtggtg tctgctagtc tctggggtac caggcacaat gagcgccgct     2760

tctttaagaa cttaaagaag ttcatctcgt tggggaaata cggcaagcta tcactgcagg     2820

aactgatgtg gaagatgaaa gtagaggatt gccactggct ccgcagcagc ccggggaagg     2880

accgtgtccc cgctgcagag caccgtctga ggagaggatc ctggctacgt tcctgttctg     2940

gctgatggac acatacgtgg tacagctgct taggtcattc ttttacatca cagagagcac     3000

attccagaag aacaggctct tcttctaccg taagagtgtg tggagcaagc tgcagagcat     3060

tggagtcagg caacaccttg agagagtgcg gctacgggag ctgtcacaag aggaggtcag     3120

gcatcaccag gacacctggc tagccatgcc catctgcaga ctgcgcttca tccccaagcc     3180

caacggcctg cggcccattg tgaacatgag ttatagcatg ggtaccagag ctttgggcag     3240

aaggaagcag gcccagcatt tcacccagcg tctcaagact ctcttcagca tgctcaacta     3300

tgagcggaca aaacatcctc accttatggg gtcttctgta ctgggtatga atgacatcta     3360

caggacctgg cgggcctttg tgctgcgtgt gcgtgctctg gaccagacac ccaggatgta     3420

ctttgttaag gcagatgtga ccggggccta tgatgccatc cccccagggt aagctggtgg     3480

aggttgttgc caatatgatc aggcactcgg agagcacgta ctgtatccgc cagtatgcag     3540

tggtccggag agatagccaa ggccaagtcc acaagtcctt taggagacag gtcaccaccc     3600

tctctgacct ccagccatac atgggccagt tccttaagca tctgcaggat tcagatgcca     3660

gtgcactgag gaactccgtt gtcatcgagc agagcatctc tatgaatgag agcagcagca     3720

gcctgtttga cttcttcctg cacttcctgc gtcacagtgt cgtaaagatt ggtgacaggt     3780

gctatacgca gtgccagggc atcccccagg gctccagcct atccaccctg ctctgcagtc     3840

tgtgtttcgg agacatggag aacaagctgt ttgctgaggt gcagcgggat gggttgcttt     3900

tacgttttgt tgatgacttt ctgttggtga cgcctcactt ggaccaagca aaaaccttcc     3960

tcagcaccct ggtccatggc gttcctgagt atgggtgcat gataaacttg cagaagacag     4020

tggtgaactt ccctgtggag cctggtaccc tgggtggtgc agctccatac cagctgcctg     4080

ctcactgcct gtttccctgg tgtggcttgc tgctggacac tcagactttg gaggtgttct     4140

gtgactactc aggttatgcc cagacctcaa ttaagacgag cctcaccttc cagagtgtct     4200

tcaaagctgg gaagaccatg cggaacaagc tcctgtcggt cttgcggttg aagtgtcacg     4260

gtctatttct agacttgcag gtgaacagcc tccagacagt ctgcatcaat atatacaaga     4320

tcttcctgct tcaggcctac aggttccatg catgtgtgat tcagcttccc tttgaccagc     4380

gtgttaggaa gaacctcaca ttctttctgg gcatcatctc cagccaagca tcctgctgct     4440

atgctatcct gaaggtcaag aatccaggaa tgacactaaa ggcctctggc tcctttcctc     4500

ctgaagccgc acattggctc tgctaccagg ccttcctgct caagctggct gctcattctg     4560

tcatctacaa atgtctcctg ggacctctga ggacagccca aaaactgctg tgccggaagc     4620

tcccagaggc gacaatgacc atccttaaag ctgcagctga cccagcccta agcacagact     4680

ttcagaccat tttggactaa ccctgtctcc ttccgctaga tgaacatggg cattgtagcc     4740

tcagcactcc tggatccacg tcacaagagg gactggtcag ttgtgaggct aggtcatcct     4800

ccaaacctct gtgtcatggg tggtatggga gattgtccca gtgccttgtt tcctgtaaca     4860

ggcttgattt ctttcctgat gccctcaggg aggcagatcc tatccctttt agtggcaggg     4920

atccactagc accagcacat gaggagtgca cccagtgcac atgggcactg ggacagtgga     4980

caggtgtgag attcctgggc cctggagtct tttcacacct aaccatggga gcctgtccca     5040

gtacatcaga gtgcctcgga gatgaaaaag gacatcgagc cagtgaccta aattacagcc     5100

tgaatatact ctgaattccc cggggatcct ctagagtcga cctgcagaag ctgtaaccac     5160

gtgcggaccg agcggccgca ggaaccccta gtgatggagt tggccactcc ctctctgcgc     5220

gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg     5280

gcggcctcag tgagcgagcg agcgcgcagc tgcctgcagg                           5320


<210> 26
<211> 2831
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV-CMV-GFP recombinant adeno-associated virus genome

<400> 26
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgca cgcgtggagc tagttattaa tagtaatcaa     180

ttacggggtc attagttcat agcccatata tggagttccg cgttacataa cttacggtaa     240

atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg     300

ttcccatagt aacgtcaata gggactttcc attgacgtca atgggtggag tatttacggt     360

aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg     420

tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc     480

ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg cggttttggc     540

agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca     600

ttgacgtcaa tgggagtttg ttttgcacca aaatcaacgg gactttccaa aatgtcgtaa     660

caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag     720

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct     780

ccatagaaga caccgggacc gatccagcct ccgcggattc gaatcccggc cgggaacggt     840

gcattggaac gcggattccc cgtgccaaga gtgacgtaag taccgcctat agagtctata     900

ggcccacaaa aaatgctttc ttcttttaat atactttttt gtttatctta tttctaatac     960

tttccctaat ctctttcttt cagggcaata atgatacaat gtatcatgcc tctttgcacc    1020

attctaaaga ataacagtga taatttctgg gttaaggcaa tagcaatatt tctgcatata    1080

aatatttctg catataaatt gtaactgatg taagaggttt catattgcta atagcagcta    1140

caatccagct accattctgc ttttatttta tggttgggat aaggctggat tattctgagt    1200

ccaagctagg cccttttgct aatcatgttc atacctctta tcttcctccc acagctcctg    1260

ggcaacgtgc tggtctgtgt gctggcccat cactttggca aagaattggg attcgaacat    1320

tcgagcgcaa gcttgagcta gcgctaccgg tcgccaccat ggtgagcaag ggcgaggagc    1380

tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt    1440

tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca    1500

tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg    1560

gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg    1620

ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca    1680

agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg    1740

gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca    1800

gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga    1860

tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc    1920

ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc    1980

tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg    2040

ccgggatcac tctcggcatg gacgagctgt acaagtccgg actcagatct cgagctcaag    2100

cttcgaattc tgcagtcgac ggtaccgcgg gcccgggatc caccggatct agataactga    2160

tccgcgcgat ctacgggtgg catccctgtg acccctcccc agtgcctctc ctggccctgg    2220

aagttgccac tccagtgccc accagccttg tcctaataaa attaagttgc atcattttgt    2280

ctgactaggt gtccttctat aatattatgg ggtggagggg ggtggtatgg agcaaggggc    2340

aagttgggaa gacaacctgt agggcctgcg gggtctattg ggaaccaagc tggagtgcag    2400

tggcacaatc ttggctcact gcaatctccg cctcctgggt tcaagcgatt ctcctgcctc    2460

agcctcccga gttgttggga ttccaggcat gcatgaccag gctcagctaa tttttgtttt    2520

tttggtagag acggggtttc accatattgg ccaggctggt ctccaactcc taatctcagg    2580

tgatctaccc accttggcct cccaaattgc tgggattaca ggcgtgaacc actgctccct    2640

tccctgtcct tctgattttg taggtaacca cgtgcggacc gagcggccgc aggaacccct    2700

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc    2760

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag    2820

ctgcctgcag g                                                         2831


<210> 27
<211> 1962
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV-SpB-GFP recombinant adeno-associated virus genome

<400> 27
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgcg atatcatagg gctgtctggg agccactcca     180

gggccacaga aatcttgtct ctgactcagg gtattttgtt ttctgttttg tgtaaatgct     240

cttctgacta atgcaaacca tgtgtccata gaaccagaag atttttccag gggaaaaggt     300

aaggaggtgg tgagagtgtc ctgggtctgc ccttccaggg cttgccctgg gttaagagcc     360

aggcaggaag ctctcaagag cattgctcaa gagtagaggg ggcctgggag gcccagggag     420

gggatgggag gggaacaccc aggctgcccc caaccagatg ccctccaccc tcctcaacct     480

ccctcccacg gcctggagag gtgggaccag gtatggaggc ttgagagccc ctggttggag     540

gaagccacaa gtccaggaac atgggagtct gggcaggggg caaaggaggc aggaacaggc     600

catcagccag gacaggtggt aaggcaggca ggagtgttcc tgctgggaaa aggtgggatc     660

aagcacctgg agggctcttc agagcaaaga caaacactga ggtcgctgcc actcctacag     720

agcccccacg ccccgcccag ctataagggg ccatgcacca agcagggtac ccaggctgca     780

gaggtgcgaa ttcatttaaa ttctagagcc accatggtga gcaagggcga ggagctgttc     840

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc     900

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc     960

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg    1020

cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg    1080

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc    1140

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc    1200

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac    1260

aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc    1320

cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc    1380

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc    1440

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg    1500

atcactctcg gcatggacga gctgtacaag taaactcgag catttaaata cgtggagctc    1560

gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg    1620

tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa    1680

ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca    1740

gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg    1800

ccacgtggat atcgcggccg caggaacccc tagtgatgga gttggccact ccctctctgc    1860

gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc    1920

gggcggcctc agtgagcgag cgagcgcgca gctgcctgca gg                       1962


<210> 28
<211> 1214
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV6-SpB-null genome and AAV9-SpB-null virus genome

<400> 28
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgcg atatcatagg gctgtctggg agccactcca     180

gggccacaga aatcttgtct ctgactcagg gtattttgtt ttctgttttg tgtaaatgct     240

cttctgacta atgcaaacca tgtgtccata gaaccagaag atttttccag gggaaaaggt     300

aaggaggtgg tgagagtgtc ctgggtctgc ccttccaggg cttgccctgg gttaagagcc     360

aggcaggaag ctctcaagag cattgctcaa gagtagaggg ggcctgggag gcccagggag     420

gggatgggag gggaacaccc aggctgcccc caaccagatg ccctccaccc tcctcaacct     480

ccctcccacg gcctggagag gtgggaccag gtatggaggc ttgagagccc ctggttggag     540

gaagccacaa gtccaggaac atgggagtct gggcaggggg caaaggaggc aggaacaggc     600

catcagccag gacaggtggt aaggcaggca ggagtgttcc tgctgggaaa aggtgggatc     660

aagcacctgg agggctcttc agagcaaaga caaacactga ggtcgctgcc actcctacag     720

agcccccacg ccccgcccag ctataagggg ccatgcacca agcagggtac ccaggctgca     780

gaggtgcgaa ttcatttaaa tacgtggagc tcgctgatca gcctcgactg tgccttctag     840

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     900

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     960

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag    1020

caggcatgct ggggatgcgg tgggctctat ggccacgtgg atatcgcggc cgcaggaacc    1080

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg    1140

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg    1200

cagctgcctg cagg                                                      1214


<210> 29
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Set 1 Forward

<400> 29
tagccctggc aaggataga                                                 19


<210> 30
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Set 1 Reverse

<400> 30
gctctcggtg atgtagaaga ag                                             22


<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Set 2 Forward

<400> 31
caccagacac aacgagagaa g                                              21


<210> 32
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Set 2 reverse

<400> 32
ctcgaccttc atcttccaca tc                                             22


<210> 33
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> GFP forward primer

<400> 33
agctggacgg cgacgtaa                                                  18


<210> 34
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> GFP reverse primer

<400> 34
gtgcagatga acttcagggt ca                                             22


<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> moTERT forward primer

<400> 35
caccagacac aacgagagaa g                                              21


<210> 36
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> moTERT reverse primer

<400> 36
ctcgaccttc atcttccaca tc                                             22


<210> 37
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> FAM-Probe

<400> 37
agggacagct tgccgtactt cc                                             22


<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR2 forward primer

<400> 38
ggaaccccta gtgatggagt t                                              21


<210> 39
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR2 reverse primer

<400> 39
cggcctcagt gagcga                                                    16


<210> 40
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> HEX-Probe

<400> 40
cactccctct ctgcgcgctc g                                              21


<210> 41
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> moTERT forward primer

<400> 41
ggaagtgttc tgcgactaca g                                              21


<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> moTERT reverse primer

<400> 42
cagcttgttc ctcatggtct t                                              21


<210> 43
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> probe /56FAM

<220> 
<221> misc_feature
<222> 10
<223> /note="n= ZEN"

<400> 43
ctacgcccan gaccagcatc aagac                                          25


<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> hRplp0 forward primer

<400> 44
cagacagaca ctggcaacat                                                20


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> hRplp0 reverse primer

<400> 45
gcagcatcta caaccctgaa                                                20


<210> 46
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> Probe: /5HEX

<220> 
<221> misc_feature
<222> 10
<223> /note="n=ZEN"

<400> 46
aactctgcan ttctcgcttc ctgga                                          25


