                         SEQUENCE LISTING

<110>  Fondazione Telethon
 
<120>  VECTOR SYSTEM

<130>  P122384PCT

<140>  PCT/EP2022/062989
<141>  2022-05-12

<150>  EP21173687.1
<151>  2021-05-12

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary CBA promoter

<400>  1
gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt       60

ttgtatttat ttatttttta attattttgt gcagcgatgg gggcggggcg gggcgaggcg      120

gagaggtgcg gcggcagcca atcggagcgg cgcgctccga aagtttcctt ttatggcgag      180

gcggcggcgg cggcggctct ataaaaagcg aagcgcgcgg cgggcgg                    227


<210>  2
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example CMV enhancer

<400>  2
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattacca                                                    378


<210>  3
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example SV40 intron sequence

<400>  3
ctctaaggta aatataaaat ttttaagtgt ataatgtgtt aaactactga ttctaattgt       60

ttctctcttt tagattccaa cctttggaac tga                                    93


<210>  4
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example MVM intron sequence

<400>  4
aagaggtaag ggtttaaggg atggttggtt ggtggggtat taatgtttaa ttacctggag       60

cacctgcctg aaatcacttt ttttcaggtt gg                                     92


<210>  5
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example splice donor sequence

<400>  5
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ct                                                82


<210>  6
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example splice acceptor sequence

<400>  6
gataggcacc tattggtctt actgacatcc actttgcctt tctctccaca g                51


<210>  7
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary recombinogenic region sequence (AK)

<400>  7
gggatttttc cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac       60

gcgaatttta acaaaat                                                      77


<210>  8
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary polyadenylation sequence

<400>  8
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctgggga                                         208


<210>  9
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example 5' ITR

<400>  9
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  10
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example 3' ITR

<400>  10
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  11
<211>  6648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example MYO7A nucleotide sequence

<400>  11
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggcatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

aacaagccca tgaacatcat ctccctcatc gatgaggaga gcaagttccc caagggcaca     1560

gacaccacca tgttacacaa gctgaactcc cagcacaagc tcaacgccaa ctacatcccc     1620

cccaagaaca accatgagac ccagtttggc atcaaccatt ttgcaggcat cgtctactat     1680

gagacccaag gcttcctgga gaagaaccga gacaccctgc atggggacat tatccagctg     1740

gtccactcct ccaggaacaa gttcatcaag cagatcttcc aggccgatgt cgccatgggc     1800

gccgagacca ggaagcgctc gcccacactt agcagccagt tcaagcggtc actggagctg     1860

ctgatgcgca cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa gcccaatgag     1920

ttcaagaagc ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg gtactcagga     1980

atgatggaga ccatccgaat ccgccgagct ggctacccca tccgctacag cttcgtagag     2040

tttgtggagc ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa gcagggcgac     2100

ctccgcggga cttgccagcg catggctgag gctgtgctgg gcacccacga tgactggcag     2160

ataggcaaaa ccaagatctt tctgaaggac caccatgaca tgctgctgga agtggagcgg     2220

gacaaagcca tcaccgacag agtcatcctc cttcagaaag tcatccgggg attcaaagac     2280

aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt     2340

cacaactgta ggaagaacta cgggctgatg cgtctgggct tcctgcggct gcaggccctg     2400

caccgctccc ggaagctgca ccagcagtac cgcctggccc gccagcgcat catccagttc     2460

caggcccgct gccgcgccta tctggtgcgc aaggccttcc gccaccgcct ctgggctgtg     2520

ctcaccgtgc aggcctatgc ccggggcatg atcgcccgca ggctgcacca acgcctcagg     2580

gctgagtatc tgtggcgcct cgaggctgag aaaatgcggc tggcggagga agagaagctt     2640

cggaaggaga tgagcgccaa gaaggccaag gaggaggccg agcgcaagca tcaggagcgc     2700

ctggcccagc tggctcgtga ggacgctgag cgggagctga aggagaagga ggccgctcgg     2760

cggaagaagg agctcctgga gcagatggaa agggcccgcc atgagcctgt caatcactca     2820

gacatggtgg acaagatgtt tggcttcctg gggacttcag gtggcctgcc aggccaggag     2880

ggccaggcac ctagtggctt tgaggacctg gagcgagggc ggagggagat ggtggaggag     2940

gacctggatg cagccctgcc cctgcctgac gaggatgagg aggacctctc tgagtataaa     3000

tttgccaagt tcgcggccac ctacttccag gggacaacta cgcactccta cacccggcgg     3060

ccactcaaac agccactgct ctaccatgac gacgagggtg accagctggc agccctggcg     3120

gtctggatca ccatcctccg cttcatgggg gacctccctg agcccaagta ccacacagcc     3180

atgagtgatg gcagtgagaa gatccctgtg atgaccaaga tttatgagac cctgggcaag     3240

aagacgtaca agagggagct gcaggccctg cagggcgagg gcgaggccca gctccccgag     3300

ggccagaaga agagcagtgt gaggcacaag ctggtgcatt tgactctgaa aaagaagtcc     3360

aagctcacag aggaggtgac caagaggctg catgacgggg agtccacagt gcagggcaac     3420

agcatgctgg aggaccggcc cacctccaac ctggagaagc tgcacttcat catcggcaat     3480

ggcatcctgc ggccagcact ccgggacgag atctactgcc agatcagcaa gcagctgacc     3540

cacaacccct ccaagagcag ctatgcccgg ggctggattc tcgtgtctct ctgcgtgggc     3600

tgtttcgccc cctccgagaa gtttgtcaag tacctgcgga acttcatcca cgggggcccg     3660

cccggctacg ccccgtactg tgaggagcgc ctgagaagga cctttgtcaa tgggacacgg     3720

acacagccgc ccagctggct ggagctgcag gccaccaagt ccaagaagcc aatcatgttg     3780

cccgtgacat tcatggatgg gaccaccaag accctgctga cggactcggc aaccacggcc     3840

aaggagctct gcaacgcgct ggccgacaag atctctctca aggaccggtt cgggttctcc     3900

ctctacattg ccctgtttga caaggtgtcc tccctgggca gcggcagtga ccacgtcatg     3960

gacgccatct cccagtgcga gcagtacgcc aaggagcagg gcgcccagga gcgcaacgcc     4020

ccctggaggc tcttcttccg caaagaggtc ttcacgccct ggcacagccc ctccgaggac     4080

aacgtggcca ccaacctcat ctaccagcag gtggtgcgag gagtcaagtt tggggagtac     4140

aggtgtgaga aggaggacga cctggctgag ctggcctccc agcagtactt tgtagactat     4200

ggctctgaga tgatcctgga gcgcctcctg aacctcgtgc ccacctacat ccccgaccgc     4260

gagatcacgc ccctgaagac gctggagaag tgggcccagc tggccatcgc cgcccacaag     4320

aaggggattt atgcccagag gagaactgat gcccagaagg tcaaagagga tgtggtcagt     4380

tatgcccgct tcaagtggcc cttgctcttc tccaggtttt atgaagccta caaattctca     4440

ggccccagtc tccccaagaa cgacgtcatc gtggccgtca actggacggg tgtgtacttt     4500

gtggatgagc aggagcaggt acttctggag ctgtccttcc cagagatcat ggccgtgtcc     4560

agcagcaggg agtgccgtgt ctggctctca ctgggctgct ctgatcttgg ctgtgctgcg     4620

cctcactcag gctgggcagg actgaccccg gcggggccct gttctccgtg ttggtcctgc     4680

aggggagcga aaacgacggc ccccagcttc acgctggcca ccatcaaggg ggacgaatac     4740

accttcacct ccagtaatgc tgaggacatt cgtgacctgg tggtcacctt cctagagggg     4800

ctccggaaga gatctaagta tgttgtggcc ctgcaggata accccaaccc cgcaggcgag     4860

gagtcaggct tcctcagctt tgccaaggga gacctcatca tcctggacca tgacacgggc     4920

gagcaggtca tgaactcggg ctgggccaac ggcatcaatg agaggaccaa gcagcgtggg     4980

gacttcccca ccgactgtgt gtacgtcatg cccactgtca ccatgccacc tcgtgagatt     5040

gtggccctgg tcaccatgac tcccgatcag aggcaggacg ttgtccggct cttgcagctg     5100

cgaacggcgg agcccgaggt gcgtgccaag ccctacacgc tggaggagtt ttcctatgac     5160

tacttcaggc ccccacccaa gcacacgctg agccgtgtca tggtgtccaa ggcccgaggc     5220

aaggaccggc tgtggagcca cacgcgggaa ccgctcaagc aggcgctgct caagaagctc     5280

ctgggcagtg aggagctctc gcaggaggcc tgcctggcct tcattgctgt gctcaagtac     5340

atgggcgact acccgtccaa gaggacacgc tccgtcaatg agctcaccga ccagatcttt     5400

gagggtcccc tgaaagccga gcccctgaag gacgaggcat atgtgcagat cctgaagcag     5460

ctgaccgaca accacatcag gtacagcgag gagcggggtt gggagctgct ctggctgtgc     5520

acgggccttt tcccacccag caacatcctc ctgccccacg tgcagcgctt cctgcagtcc     5580

cgaaagcact gcccactcgc catcgactgc ctgcaacggc tccagaaagc cctgagaaac     5640

gggtcccgga agtaccctcc gcacctggtg gaggtggagg ccatccagca caagaccacc     5700

cagattttcc acaaggtcta cttccctgat gacactgacg aggccttcga agtggagtcc     5760

agcaccaagg ccaaggactt ctgccagaac atcgccacca ggctgctcct caagtcctca     5820

gagggattca gcctctttgt caaaattgca gacaaggtca tcagcgttcc tgagaatgac     5880

ttcttctttg actttgttcg acacttgaca gactggataa agaaagctcg gcccatcaag     5940

gacggaattg tgccctcact cacctaccag gtgttcttca tgaagaagct gtggaccacc     6000

acggtgccag ggaaggatcc catggccgat tccatcttcc actattacca ggagttgccc     6060

aagtatctcc gaggctacca caagtgcacg cgggaggagg tgctgcagct gggggcgctg     6120

atctacaggg tcaagttcga ggaggacaag tcctacttcc ccagcatccc caagctgctg     6180

cgggagctgg tgccccagga ccttatccgg caggtctcac ctgatgactg gaagcggtcc     6240

atcgtcgcct acttcaacaa gcacgcaggg aagtccaagg aggaggccaa gctggccttc     6300

ctgaagctca tcttcaagtg gcccaccttt ggctcagcct tcttcgaggt gaagcaaact     6360

acggagccaa acttccctga gatcctccta attgccatca acaagtatgg ggtcagcctc     6420

atcgatccca aaacgaagga tatcctcacc actcatccct tcaccaagat ctccaactgg     6480

agcagcggca acacctactt ccacatcacc attgggaact tggtgcgcgg gagcaaactg     6540

ctctgcgaga cgtcactggg ctacaagatg gatgacctcc tgacttccta cattagccag     6600

atgctcacag ccatgagcaa acagcggggc tccaggagcg gcaagtga                  6648


<210>  12
<211>  3108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example 5' end portion of a MYO7A transgene

<400>  12
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggcatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

aacaagccca tgaacatcat ctccctcatc gatgaggaga gcaagttccc caagggcaca     1560

gacaccacca tgttacacaa gctgaactcc cagcacaagc tcaacgccaa ctacatcccc     1620

cccaagaaca accatgagac ccagtttggc atcaaccatt ttgcaggcat cgtctactat     1680

gagacccaag gcttcctgga gaagaaccga gacaccctgc atggggacat tatccagctg     1740

gtccactcct ccaggaacaa gttcatcaag cagatcttcc aggccgatgt cgccatgggc     1800

gccgagacca ggaagcgctc gcccacactt agcagccagt tcaagcggtc actggagctg     1860

ctgatgcgca cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa gcccaatgag     1920

ttcaagaagc ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg gtactcagga     1980

atgatggaga ccatccgaat ccgccgagct ggctacccca tccgctacag cttcgtagag     2040

tttgtggagc ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa gcagggcgac     2100

ctccgcggga cttgccagcg catggctgag gctgtgctgg gcacccacga tgactggcag     2160

ataggcaaaa ccaagatctt tctgaaggac caccatgaca tgctgctgga agtggagcgg     2220

gacaaagcca tcaccgacag agtcatcctc cttcagaaag tcatccgggg attcaaagac     2280

aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt     2340

cacaactgta ggaagaacta cgggctgatg cgtctgggct tcctgcggct gcaggccctg     2400

caccgctccc ggaagctgca ccagcagtac cgcctggccc gccagcgcat catccagttc     2460

caggcccgct gccgcgccta tctggtgcgc aaggccttcc gccaccgcct ctgggctgtg     2520

ctcaccgtgc aggcctatgc ccggggcatg atcgcccgca ggctgcacca acgcctcagg     2580

gctgagtatc tgtggcgcct cgaggctgag aaaatgcggc tggcggagga agagaagctt     2640

cggaaggaga tgagcgccaa gaaggccaag gaggaggccg agcgcaagca tcaggagcgc     2700

ctggcccagc tggctcgtga ggacgctgag cgggagctga aggagaagga ggccgctcgg     2760

cggaagaagg agctcctgga gcagatggaa agggcccgcc atgagcctgt caatcactca     2820

gacatggtgg acaagatgtt tggcttcctg gggacttcag gtggcctgcc aggccaggag     2880

ggccaggcac ctagtggctt tgaggacctg gagcgagggc ggagggagat ggtggaggag     2940

gacctggatg cagccctgcc cctgcctgac gaggatgagg aggacctctc tgagtataaa     3000

tttgccaagt tcgcggccac ctacttccag gggacaacta cgcactccta cacccggcgg     3060

ccactcaaac agccactgct ctaccatgac gacgagggtg accagctg                  3108


<210>  13
<211>  3540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example 3' end portion of a MYO7A transgene

<400>  13
gcagccctgg cggtctggat caccatcctc cgcttcatgg gggacctccc tgagcccaag       60

taccacacag ccatgagtga tggcagtgag aagatccctg tgatgaccaa gatttatgag      120

accctgggca agaagacgta caagagggag ctgcaggccc tgcagggcga gggcgaggcc      180

cagctccccg agggccagaa gaagagcagt gtgaggcaca agctggtgca tttgactctg      240

aaaaagaagt ccaagctcac agaggaggtg accaagaggc tgcatgacgg ggagtccaca      300

gtgcagggca acagcatgct ggaggaccgg cccacctcca acctggagaa gctgcacttc      360

atcatcggca atggcatcct gcggccagca ctccgggacg agatctactg ccagatcagc      420

aagcagctga cccacaaccc ctccaagagc agctatgccc ggggctggat tctcgtgtct      480

ctctgcgtgg gctgtttcgc cccctccgag aagtttgtca agtacctgcg gaacttcatc      540

cacgggggcc cgcccggcta cgccccgtac tgtgaggagc gcctgagaag gacctttgtc      600

aatgggacac ggacacagcc gcccagctgg ctggagctgc aggccaccaa gtccaagaag      660

ccaatcatgt tgcccgtgac attcatggat gggaccacca agaccctgct gacggactcg      720

gcaaccacgg ccaaggagct ctgcaacgcg ctggccgaca agatctctct caaggaccgg      780

ttcgggttct ccctctacat tgccctgttt gacaaggtgt cctccctggg cagcggcagt      840

gaccacgtca tggacgccat ctcccagtgc gagcagtacg ccaaggagca gggcgcccag      900

gagcgcaacg ccccctggag gctcttcttc cgcaaagagg tcttcacgcc ctggcacagc      960

ccctccgagg acaacgtggc caccaacctc atctaccagc aggtggtgcg aggagtcaag     1020

tttggggagt acaggtgtga gaaggaggac gacctggctg agctggcctc ccagcagtac     1080

tttgtagact atggctctga gatgatcctg gagcgcctcc tgaacctcgt gcccacctac     1140

atccccgacc gcgagatcac gcccctgaag acgctggaga agtgggccca gctggccatc     1200

gccgcccaca agaaggggat ttatgcccag aggagaactg atgcccagaa ggtcaaagag     1260

gatgtggtca gttatgcccg cttcaagtgg cccttgctct tctccaggtt ttatgaagcc     1320

tacaaattct caggccccag tctccccaag aacgacgtca tcgtggccgt caactggacg     1380

ggtgtgtact ttgtggatga gcaggagcag gtacttctgg agctgtcctt cccagagatc     1440

atggccgtgt ccagcagcag ggagtgccgt gtctggctct cactgggctg ctctgatctt     1500

ggctgtgctg cgcctcactc aggctgggca ggactgaccc cggcggggcc ctgttctccg     1560

tgttggtcct gcaggggagc gaaaacgacg gcccccagct tcacgctggc caccatcaag     1620

ggggacgaat acaccttcac ctccagtaat gctgaggaca ttcgtgacct ggtggtcacc     1680

ttcctagagg ggctccggaa gagatctaag tatgttgtgg ccctgcagga taaccccaac     1740

cccgcaggcg aggagtcagg cttcctcagc tttgccaagg gagacctcat catcctggac     1800

catgacacgg gcgagcaggt catgaactcg ggctgggcca acggcatcaa tgagaggacc     1860

aagcagcgtg gggacttccc caccgactgt gtgtacgtca tgcccactgt caccatgcca     1920

cctcgtgaga ttgtggccct ggtcaccatg actcccgatc agaggcagga cgttgtccgg     1980

ctcttgcagc tgcgaacggc ggagcccgag gtgcgtgcca agccctacac gctggaggag     2040

ttttcctatg actacttcag gcccccaccc aagcacacgc tgagccgtgt catggtgtcc     2100

aaggcccgag gcaaggaccg gctgtggagc cacacgcggg aaccgctcaa gcaggcgctg     2160

ctcaagaagc tcctgggcag tgaggagctc tcgcaggagg cctgcctggc cttcattgct     2220

gtgctcaagt acatgggcga ctacccgtcc aagaggacac gctccgtcaa tgagctcacc     2280

gaccagatct ttgagggtcc cctgaaagcc gagcccctga aggacgaggc atatgtgcag     2340

atcctgaagc agctgaccga caaccacatc aggtacagcg aggagcgggg ttgggagctg     2400

ctctggctgt gcacgggcct tttcccaccc agcaacatcc tcctgcccca cgtgcagcgc     2460

ttcctgcagt cccgaaagca ctgcccactc gccatcgact gcctgcaacg gctccagaaa     2520

gccctgagaa acgggtcccg gaagtaccct ccgcacctgg tggaggtgga ggccatccag     2580

cacaagacca cccagatttt ccacaaggtc tacttccctg atgacactga cgaggccttc     2640

gaagtggagt ccagcaccaa ggccaaggac ttctgccaga acatcgccac caggctgctc     2700

ctcaagtcct cagagggatt cagcctcttt gtcaaaattg cagacaaggt catcagcgtt     2760

cctgagaatg acttcttctt tgactttgtt cgacacttga cagactggat aaagaaagct     2820

cggcccatca aggacggaat tgtgccctca ctcacctacc aggtgttctt catgaagaag     2880

ctgtggacca ccacggtgcc agggaaggat cccatggccg attccatctt ccactattac     2940

caggagttgc ccaagtatct ccgaggctac cacaagtgca cgcgggagga ggtgctgcag     3000

ctgggggcgc tgatctacag ggtcaagttc gaggaggaca agtcctactt ccccagcatc     3060

cccaagctgc tgcgggagct ggtgccccag gaccttatcc ggcaggtctc acctgatgac     3120

tggaagcggt ccatcgtcgc ctacttcaac aagcacgcag ggaagtccaa ggaggaggcc     3180

aagctggcct tcctgaagct catcttcaag tggcccacct ttggctcagc cttcttcgag     3240

gtgaagcaaa ctacggagcc aaacttccct gagatcctcc taattgccat caacaagtat     3300

ggggtcagcc tcatcgatcc caaaacgaag gatatcctca ccactcatcc cttcaccaag     3360

atctccaact ggagcagcgg caacacctac ttccacatca ccattgggaa cttggtgcgc     3420

gggagcaaac tgctctgcga gacgtcactg ggctacaaga tggatgacct cctgacttcc     3480

tacattagcc agatgctcac agccatgagc aaacagcggg gctccaggag cggcaagtga     3540


<210>  14
<211>  4488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector

<400>  14
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcc ttatcgggaa ttcgccctta agctagcgtg ccacctggtc gacattgatt      240

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      300

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      360

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      420

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      480

tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      540

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      600

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      660

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      720

gcggggcgag gcggagaggt gcggcggcag ccaatcggag cggcgcgctc cgaaagtttc      780

cttttatggc gaggcggcgg cggcggcggc tctataaaaa gcgaagcgcg cggcgggcgg      840

ctgcagaagt tggtcgtgag gcactgggca gctctaaggt aaatataaaa tttttaagtg      900

tataatgtgt taaactactg attctaattg tttctctctt ttagattcca acctttggaa      960

ctgagtgtcc aggcggccgc catggtgatt cttcagcagg gggaccatgt gtggatggac     1020

ctgagattgg ggcaggagtt cgacgtgccc atcggggcgg tggtgaagct ctgcgactct     1080

gggcaggtcc aggtggtgga tgatgaagac aatgaacact ggatctctcc gcagaacgca     1140

acgcacatca agcctatgca ccccacgtcg gtccacggcg tggaggacat gatccgcctg     1200

ggggacctca acgaggcggg catcttgcgc aacctgctta tccgctaccg ggaccacctc     1260

atctacacgt atacgggctc catcctggtg gctgtgaacc cctaccagct gctctccatc     1320

tactcgccag agcacatccg ccagtatacc aacaagaaga ttggggagat gcccccccac     1380

atctttgcca ttgctgacaa ctgctacttc aacatgaaac gcaacagccg agaccagtgc     1440

tgcatcatca gtggggaatc tggggccggg aagacggaga gcacaaagct gatcctgcag     1500

ttcctggcag ccatcagtgg gcagcactcg tggattgagc agcaggtctt ggaggccacc     1560

cccattctgg aagcatttgg gaatgccaag accatccgca atgacaactc aagccgtttc     1620

ggaaagtaca tcgacatcca cttcaacaag cggggcgcca tcgagggcgc gaagattgag     1680

cagtacctgc tggaaaagtc acgtgtctgt cgccaggccc tggatgaaag gaactaccac     1740

gtgttctact gcatgctgga gggcatgagt gaggatcaga agaagaagct gggcttgggc     1800

caggcctctg actacaacta cttggccatg ggtaactgca taacctgtga gggccgggtg     1860

gacagccagg agtacgccaa catccgctcc gccatgaagg tgctcatgtt cactgacacc     1920

gagaactggg agatctcgaa gctcctggct gccatcctgc acctgggcaa cctgcagtat     1980

gaggcacgca catttgaaaa cctggatgcc tgtgaggttc tcttctcccc atcgctggcc     2040

acagctgcat ccctgcttga ggtgaacccc ccagacctga tgagctgcct gactagccgc     2100

accctcatca cccgcgggga gacggtgtcc accccactga gcagggaaca ggcactggac     2160

gtgcgcgacg ccttcgtaaa ggggatctac gggcggctgt tcgtgtggat tgtggacaag     2220

atcaacgcag caatttacaa gcctccctcc caggatgtga agaactctcg caggtccatc     2280

ggcctcctgg acatctttgg gtttgagaac tttgctgtga acagctttga gcagctctgc     2340

atcaacttcg ccaatgagca cctgcagcag ttctttgtgc ggcacgtgtt caagctggag     2400

caggaggaat atgacctgga gagcattgac tggctgcaca tcgagttcac tgacaaccag     2460

gatgccctgg acatgattgc caacaagccc atgaacatca tctccctcat cgatgaggag     2520

agcaagttcc ccaagggcac agacaccacc atgttacaca agctgaactc ccagcacaag     2580

ctcaacgcca actacatccc ccccaagaac aaccatgaga cccagtttgg catcaaccat     2640

tttgcaggca tcgtctacta tgagacccaa ggcttcctgg agaagaaccg agacaccctg     2700

catggggaca ttatccagct ggtccactcc tccaggaaca agttcatcaa gcagatcttc     2760

caggccgatg tcgccatggg cgccgagacc aggaagcgct cgcccacact tagcagccag     2820

ttcaagcggt cactggagct gctgatgcgc acgctgggtg cctgccagcc cttctttgtg     2880

cgatgcatca agcccaatga gttcaagaag cccatgctgt tcgaccggca cctgtgcgtg     2940

cgccagctgc ggtactcagg aatgatggag accatccgaa tccgccgagc tggctacccc     3000

atccgctaca gcttcgtaga gtttgtggag cggtaccgtg tgctgctgcc aggtgtgaag     3060

ccggcctaca agcagggcga cctccgcggg acttgccagc gcatggctga ggctgtgctg     3120

ggcacccacg atgactggca gataggcaaa accaagatct ttctgaagga ccaccatgac     3180

atgctgctgg aagtggagcg ggacaaagcc atcaccgaca gagtcatcct ccttcagaaa     3240

gtcatccggg gattcaaaga caggtctaac tttctgaagc tgaagaacgc tgccacactg     3300

atccagaggc actggcgggg tcacaactgt aggaagaact acgggctgat gcgtctgggc     3360

ttcctgcggc tgcaggccct gcaccgctcc cggaagctgc accagcagta ccgcctggcc     3420

cgccagcgca tcatccagtt ccaggcccgc tgccgcgcct atctggtgcg caaggccttc     3480

cgccaccgcc tctgggctgt gctcaccgtg caggcctatg cccggggcat gatcgcccgc     3540

aggctgcacc aacgcctcag ggctgagtat ctgtggcgcc tcgaggctga gaaaatgcgg     3600

ctggcggagg aagagaagct tcggaaggag atgagcgcca agaaggccaa ggaggaggcc     3660

gagcgcaagc atcaggagcg cctggcccag ctggctcgtg aggacgctga gcgggagctg     3720

aaggagaagg aggccgctcg gcggaagaag gagctcctgg agcagatgga aagggcccgc     3780

catgagcctg tcaatcactc agacatggtg gacaagatgt ttggcttcct ggggacttca     3840

ggtggcctgc caggccagga gggccaggca cctagtggct ttgaggacct ggagcgaggg     3900

cggagggaga tggtggagga ggacctggat gcagccctgc ccctgcctga cgaggatgag     3960

gaggacctct ctgagtataa atttgccaag ttcgcggcca cctacttcca ggggacaact     4020

acgcactcct acacccggcg gccactcaaa cagccactgc tctaccatga cgacgagggt     4080

gaccagctgg taagtatcaa ggttacaaga caggtttaag gagaccaata gaaactgggc     4140

ttgtcgagac agagaagact cttgcgtttc tgggattttt ccgatttcgg cctattggtt     4200

aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgtttat     4260

aatttcaggt ggcatctttc caattgaagg gcgaattccg atcttcctag agcatggcta     4320

cgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     4380

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     4440

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcag                  4488


<210>  15
<211>  4383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector

<400>  15
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttatatgatc agggattttt ccgatttcgg cctattggtt      240

aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgtttat      300

aatttcaggt ggcatctttc gataggcacc tattggtctt actgacatcc actttgcctt      360

tctctccaca ggcagccctg gcggtctgga tcaccatcct ccgcttcatg ggggacctcc      420

ctgagcccaa gtaccacaca gccatgagtg atggcagtga gaagatccct gtgatgacca      480

agatttatga gaccctgggc aagaagacgt acaagaggga gctgcaggcc ctgcagggcg      540

agggcgaggc ccagctcccc gagggccaga agaagagcag tgtgaggcac aagctggtgc      600

atttgactct gaaaaagaag tccaagctca cagaggaggt gaccaagagg ctgcatgacg      660

gggagtccac agtgcagggc aacagcatgc tggaggaccg gcccacctcc aacctggaga      720

agctgcactt catcatcggc aatggcatcc tgcggccagc actccgggac gagatctact      780

gccagatcag caagcagctg acccacaacc cctccaagag cagctatgcc cggggctgga      840

ttctcgtgtc tctctgcgtg ggctgtttcg ccccctccga gaagtttgtc aagtacctgc      900

ggaacttcat ccacgggggc ccgcccggct acgccccgta ctgtgaggag cgcctgagaa      960

ggacctttgt caatgggaca cggacacagc cgcccagctg gctggagctg caggccacca     1020

agtccaagaa gccaatcatg ttgcccgtga cattcatgga tgggaccacc aagaccctgc     1080

tgacggactc ggcaaccacg gccaaggagc tctgcaacgc gctggccgac aagatctctc     1140

tcaaggaccg gttcgggttc tccctctaca ttgccctgtt tgacaaggtg tcctccctgg     1200

gcagcggcag tgaccacgtc atggacgcca tctcccagtg cgagcagtac gccaaggagc     1260

agggcgccca ggagcgcaac gccccctgga ggctcttctt ccgcaaagag gtcttcacgc     1320

cctggcacag cccctccgag gacaacgtgg ccaccaacct catctaccag caggtggtgc     1380

gaggagtcaa gtttggggag tacaggtgtg agaaggagga cgacctggct gagctggcct     1440

cccagcagta ctttgtagac tatggctctg agatgatcct ggagcgcctc ctgaacctcg     1500

tgcccaccta catccccgac cgcgagatca cgcccctgaa gacgctggag aagtgggccc     1560

agctggccat cgccgcccac aagaagggga tttatgccca gaggagaact gatgcccaga     1620

aggtcaaaga ggatgtggtc agttatgccc gcttcaagtg gcccttgctc ttctccaggt     1680

tttatgaagc ctacaaattc tcaggcccca gtctccccaa gaacgacgtc atcgtggccg     1740

tcaactggac gggtgtgtac tttgtggatg agcaggagca ggtacttctg gagctgtcct     1800

tcccagagat catggccgtg tccagcagca gggagtgccg tgtctggctc tcactgggct     1860

gctctgatct tggctgtgct gcgcctcact caggctgggc aggactgacc ccggcggggc     1920

cctgttctcc gtgttggtcc tgcaggggag cgaaaacgac ggcccccagc ttcacgctgg     1980

ccaccatcaa gggggacgaa tacaccttca cctccagtaa tgctgaggac attcgtgacc     2040

tggtggtcac cttcctagag gggctccgga agagatctaa gtatgttgtg gccctgcagg     2100

ataaccccaa ccccgcaggc gaggagtcag gcttcctcag ctttgccaag ggagacctca     2160

tcatcctgga ccatgacacg ggcgagcagg tcatgaactc gggctgggcc aacggcatca     2220

atgagaggac caagcagcgt ggggacttcc ccaccgactg tgtgtacgtc atgcccactg     2280

tcaccatgcc acctcgtgag attgtggccc tggtcaccat gactcccgat cagaggcagg     2340

acgttgtccg gctcttgcag ctgcgaacgg cggagcccga ggtgcgtgcc aagccctaca     2400

cgctggagga gttttcctat gactacttca ggcccccacc caagcacacg ctgagccgtg     2460

tcatggtgtc caaggcccga ggcaaggacc ggctgtggag ccacacgcgg gaaccgctca     2520

agcaggcgct gctcaagaag ctcctgggca gtgaggagct ctcgcaggag gcctgcctgg     2580

ccttcattgc tgtgctcaag tacatgggcg actacccgtc caagaggaca cgctccgtca     2640

atgagctcac cgaccagatc tttgagggtc ccctgaaagc cgagcccctg aaggacgagg     2700

catatgtgca gatcctgaag cagctgaccg acaaccacat caggtacagc gaggagcggg     2760

gttgggagct gctctggctg tgcacgggcc ttttcccacc cagcaacatc ctcctgcccc     2820

acgtgcagcg cttcctgcag tcccgaaagc actgcccact cgccatcgac tgcctgcaac     2880

ggctccagaa agccctgaga aacgggtccc ggaagtaccc tccgcacctg gtggaggtgg     2940

aggccatcca gcacaagacc acccagattt tccacaaggt ctacttccct gatgacactg     3000

acgaggcctt cgaagtggag tccagcacca aggccaagga cttctgccag aacatcgcca     3060

ccaggctgct cctcaagtcc tcagagggat tcagcctctt tgtcaaaatt gcagacaagg     3120

tcatcagcgt tcctgagaat gacttcttct ttgactttgt tcgacacttg acagactgga     3180

taaagaaagc tcggcccatc aaggacggaa ttgtgccctc actcacctac caggtgttct     3240

tcatgaagaa gctgtggacc accacggtgc cagggaagga tcccatggcc gattccatct     3300

tccactatta ccaggagttg cccaagtatc tccgaggcta ccacaagtgc acgcgggagg     3360

aggtgctgca gctgggggcg ctgatctaca gggtcaagtt cgaggaggac aagtcctact     3420

tccccagcat ccccaagctg ctgcgggagc tggtgcccca ggaccttatc cggcaggtct     3480

cacctgatga ctggaagcgg tccatcgtcg cctacttcaa caagcacgca gggaagtcca     3540

aggaggaggc caagctggcc ttcctgaagc tcatcttcaa gtggcccacc tttggctcag     3600

ccttcttcga ggtgaagcaa actacggagc caaacttccc tgagatcctc ctaattgcca     3660

tcaacaagta tggggtcagc ctcatcgatc ccaaaacgaa ggatatcctc accactcatc     3720

ccttcaccaa gatctccaac tggagcagcg gcaacaccta cttccacatc accattggga     3780

acttggtgcg cgggagcaaa ctgctctgcg agacgtcact gggctacaag atggatgacc     3840

tcctgacttc ctacattagc cagatgctca cagccatgag caaacagcgg ggctccagga     3900

gcggcaagtg accgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgagatctg     3960

cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     4020

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     4080

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     4140

aggattggga agacaatagc aggcatgctg gggactcgag caattcccga taaggatctt     4200

cctagagcat ggctacgtag ataagtagca tggcgggtta atcattaact acaaggaacc     4260

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg     4320

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg     4380

cag                                                                   4383


<210>  16
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric intron

<400>  16
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  17
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Splicing donor (SD) sequence

<400>  17
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ct                                                82


<210>  18
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  splice donor

<400>  18
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ct                                                82


<210>  19
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  splice acceptor

<400>  19
gataggcacc tattggtctt actgacatcc actttgcctt tctctccaca g                51


<210>  20
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AK sequence

<400>  20
gggatttttc cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac       60

gcgaatttta acaaaat                                                      77


<210>  21
<211>  4540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'CMV-ABCA4-AK

<400>  21
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatct tcaatattgg ccattagcca tattattcat tggttatata gcataaatca      240

atattggcta ttggccattg catacgttgt atctatatca taatatgtac atttatattg      300

gctcatgtcc aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat      360

caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg      420

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt      480

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac      540

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg      600

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact      660

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt      720

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc      780

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc      840

gtaataaccc cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata      900

taagcagagc tcgtttagtg aaccgtcaga tcactagaag ctttattgcg gtagtttatc      960

acagttaaat tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca     1020

gaagttggtc gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag     1080

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta     1140

ttggtcttac tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt     1200

acagctctta aggctagagt acttaatacg actcactata ggctagcctc gagaattcac     1260

gcgtggtacc tctagagtcg acccgggcgg ccgccatggg cttcgtgaga cagatacagc     1320

ttttgctctg gaagaactgg accctgcgga aaaggcaaaa gattcgcttt gtggtggaac     1380

tcgtgtggcc tttatcttta tttctggtct tgatctggtt aaggaatgcc aacccgctct     1440

acagccatca tgaatgccat ttccccaaca aggcgatgcc ctcagcagga atgctgccgt     1500

ggctccaggg gatcttctgc aatgtgaaca atccctgttt tcaaagcccc accccaggag     1560

aatctcctgg aattgtgtca aactataaca actccatctt ggcaagggta tatcgagatt     1620

ttcaagaact cctcatgaat gcaccagaga gccagcacct tggccgtatt tggacagagc     1680

tacacatctt gtcccaattc atggacaccc tccggactca cccggagaga attgcaggaa     1740

gaggaattcg aataagggat atcttgaaag atgaagaaac actgacacta tttctcatta     1800

aaaacatcgg cctgtctgac tcagtggtct accttctgat caactctcaa gtccgtccag     1860

agcagttcgc tcatggagtc ccggacctgg cgctgaagga catcgcctgc agcgaggccc     1920

tcctggagcg cttcatcatc ttcagccaga gacgcggggc aaagacggtg cgctatgccc     1980

tgtgctccct ctcccagggc accctacagt ggatagaaga cactctgtat gccaacgtgg     2040

acttcttcaa gctcttccgt gtgcttccca cactcctaga cagccgttct caaggtatca     2100

atctgagatc ttggggagga atattatctg atatgtcacc aagaattcaa gagtttatcc     2160

atcggccgag tatgcaggac ttgctgtggg tgaccaggcc cctcatgcag aatggtggtc     2220

cagagacctt tacaaagctg atgggcatcc tgtctgacct cctgtgtggc taccccgagg     2280

gaggtggctc tcgggtgctc tccttcaact ggtatgaaga caataactat aaggcctttc     2340

tggggattga ctccacaagg aaggatccta tctattctta tgacagaaga acaacatcct     2400

tttgtaatgc attgatccag agcctggagt caaatccttt aaccaaaatc gcttggaggg     2460

cggcaaagcc tttgctgatg ggaaaaatcc tgtacactcc tgattcacct gcagcacgaa     2520

ggatactgaa gaatgccaac tcaacttttg aagaactgga acacgttagg aagttggtca     2580

aagcctggga agaagtaggg ccccagatct ggtacttctt tgacaacagc acacagatga     2640

acatgatcag agataccctg gggaacccaa cagtaaaaga ctttttgaat aggcagcttg     2700

gtgaagaagg tattactgct gaagccatcc taaacttcct ctacaagggc cctcgggaaa     2760

gccaggctga cgacatggcc aacttcgact ggagggacat atttaacatc actgatcgca     2820

ccctccgcct tgtcaatcaa tacctggagt gcttggtcct ggataagttt gaaagctaca     2880

atgatgaaac tcagctcacc caacgtgccc tctctctact ggaggaaaac atgttctggg     2940

ccggagtggt attccctgac atgtatccct ggaccagctc tctaccaccc cacgtgaagt     3000

ataagatccg aatggacata gacgtggtgg agaaaaccaa taagattaaa gacaggtatt     3060

gggattctgg tcccagagct gatcccgtgg aagatttccg gtacatctgg ggcgggtttg     3120

cctatctgca ggacatggtt gaacagggga tcacaaggag ccaggtgcag gcggaggctc     3180

cagttggaat ctacctccag cagatgccct acccctgctt cgtggacgat tctttcatga     3240

tcatcctgaa ccgctgtttc cctatcttca tggtgctggc atggatctac tctgtctcca     3300

tgactgtgaa gagcatcgtc ttggagaagg agttgcgact gaaggagacc ttgaaaaatc     3360

agggtgtctc caatgcagtg atttggtgta cctggttcct ggacagcttc tccatcatgt     3420

cgatgagcat cttcctcctg acgatattca tcatgcatgg aagaatccta cattacagcg     3480

acccattcat cctcttcctg ttcttgttgg ctttctccac tgccaccatc atgctgtgct     3540

ttctgctcag caccttcttc tccaaggcca gtctggcagc agcctgtagt ggtgtcatct     3600

atttcaccct ctacctgcca cacatcctgt gcttcgcctg gcaggaccgc atgaccgctg     3660

agctgaagaa ggctgtgagc ttactgtctc cggtggcatt tggatttggc actgagtacc     3720

tggttcgctt tgaagagcaa ggcctggggc tgcagtggag caacatcggg aacagtccca     3780

cggaagggga cgaattcagc ttcctgctgt ccatgcagat gatgctcctt gatgctgctg     3840

tctatggctt actcgcttgg taccttgatc aggtgtttcc aggagactat ggaaccccac     3900

ttccttggta ctttcttcta caagagtcgt attggcttgg cggtgaaggg tgttcaacca     3960

gagaagaaag agccctggaa aagaccgagc ccctaacaga ggaaacggag gatccagagc     4020

acccagaagg aatacacgac tccttctttg aacgtgagca tccagggtgg gttcctgggg     4080

tatgcgtgaa gaatctggta aagatttttg agccctgtgg ccggccagct gtggaccgtc     4140

tgaacatcac cttctacgag aaccagatca ccgcattcct gggccacaat ggagctggga     4200

aaaccaccac cttgtaagta tcaaggttac aagacaggtt taaggagacc aatagaaact     4260

gggcttgtcg agacagagaa gactcttgcg tttctgggat ttttccgatt tcggcctatt     4320

ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt     4380

ttataatttc aggtggcatc tttccaattg aggaacccct agtgatggag ttggccactc     4440

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4500

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                           4540


<210>  22
<211>  4431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'CMV-ABCA4-TS

<400>  22
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatct tcaatattgg ccattagcca tattattcat tggttatata gcataaatca      240

atattggcta ttggccattg catacgttgt atctatatca taatatgtac atttatattg      300

gctcatgtcc aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat      360

caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg      420

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt      480

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac      540

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg      600

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact      660

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt      720

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc      780

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc      840

gtaataaccc cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata      900

taagcagagc tcgtttagtg aaccgtcaga tcactagaag ctttattgcg gtagtttatc      960

acagttaaat tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca     1020

gaagttggtc gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag     1080

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta     1140

ttggtcttac tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt     1200

acagctctta aggctagagt acttaatacg actcactata ggctagcctc gagaattcac     1260

gcgtggtacc tctagagtcg acccgggcgg ccgccatggg cttcgtgaga cagatacagc     1320

ttttgctctg gaagaactgg accctgcgga aaaggcaaaa gattcgcttt gtggtggaac     1380

tcgtgtggcc tttatcttta tttctggtct tgatctggtt aaggaatgcc aacccgctct     1440

acagccatca tgaatgccat ttccccaaca aggcgatgcc ctcagcagga atgctgccgt     1500

ggctccaggg gatcttctgc aatgtgaaca atccctgttt tcaaagcccc accccaggag     1560

aatctcctgg aattgtgtca aactataaca actccatctt ggcaagggta tatcgagatt     1620

ttcaagaact cctcatgaat gcaccagaga gccagcacct tggccgtatt tggacagagc     1680

tacacatctt gtcccaattc atggacaccc tccggactca cccggagaga attgcaggaa     1740

gaggaattcg aataagggat atcttgaaag atgaagaaac actgacacta tttctcatta     1800

aaaacatcgg cctgtctgac tcagtggtct accttctgat caactctcaa gtccgtccag     1860

agcagttcgc tcatggagtc ccggacctgg cgctgaagga catcgcctgc agcgaggccc     1920

tcctggagcg cttcatcatc ttcagccaga gacgcggggc aaagacggtg cgctatgccc     1980

tgtgctccct ctcccagggc accctacagt ggatagaaga cactctgtat gccaacgtgg     2040

acttcttcaa gctcttccgt gtgcttccca cactcctaga cagccgttct caaggtatca     2100

atctgagatc ttggggagga atattatctg atatgtcacc aagaattcaa gagtttatcc     2160

atcggccgag tatgcaggac ttgctgtggg tgaccaggcc cctcatgcag aatggtggtc     2220

cagagacctt tacaaagctg atgggcatcc tgtctgacct cctgtgtggc taccccgagg     2280

gaggtggctc tcgggtgctc tccttcaact ggtatgaaga caataactat aaggcctttc     2340

tggggattga ctccacaagg aaggatccta tctattctta tgacagaaga acaacatcct     2400

tttgtaatgc attgatccag agcctggagt caaatccttt aaccaaaatc gcttggaggg     2460

cggcaaagcc tttgctgatg ggaaaaatcc tgtacactcc tgattcacct gcagcacgaa     2520

ggatactgaa gaatgccaac tcaacttttg aagaactgga acacgttagg aagttggtca     2580

aagcctggga agaagtaggg ccccagatct ggtacttctt tgacaacagc acacagatga     2640

acatgatcag agataccctg gggaacccaa cagtaaaaga ctttttgaat aggcagcttg     2700

gtgaagaagg tattactgct gaagccatcc taaacttcct ctacaagggc cctcgggaaa     2760

gccaggctga cgacatggcc aacttcgact ggagggacat atttaacatc actgatcgca     2820

ccctccgcct tgtcaatcaa tacctggagt gcttggtcct ggataagttt gaaagctaca     2880

atgatgaaac tcagctcacc caacgtgccc tctctctact ggaggaaaac atgttctggg     2940

ccggagtggt attccctgac atgtatccct ggaccagctc tctaccaccc cacgtgaagt     3000

ataagatccg aatggacata gacgtggtgg agaaaaccaa taagattaaa gacaggtatt     3060

gggattctgg tcccagagct gatcccgtgg aagatttccg gtacatctgg ggcgggtttg     3120

cctatctgca ggacatggtt gaacagggga tcacaaggag ccaggtgcag gcggaggctc     3180

cagttggaat ctacctccag cagatgccct acccctgctt cgtggacgat tctttcatga     3240

tcatcctgaa ccgctgtttc cctatcttca tggtgctggc atggatctac tctgtctcca     3300

tgactgtgaa gagcatcgtc ttggagaagg agttgcgact gaaggagacc ttgaaaaatc     3360

agggtgtctc caatgcagtg atttggtgta cctggttcct ggacagcttc tccatcatgt     3420

cgatgagcat cttcctcctg acgatattca tcatgcatgg aagaatccta cattacagcg     3480

acccattcat cctcttcctg ttcttgttgg ctttctccac tgccaccatc atgctgtgct     3540

ttctgctcag caccttcttc tccaaggcca gtctggcagc agcctgtagt ggtgtcatct     3600

atttcaccct ctacctgcca cacatcctgt gcttcgcctg gcaggaccgc atgaccgctg     3660

agctgaagaa ggctgtgagc ttactgtctc cggtggcatt tggatttggc actgagtacc     3720

tggttcgctt tgaagagcaa ggcctggggc tgcagtggag caacatcggg aacagtccca     3780

cggaagggga cgaattcagc ttcctgctgt ccatgcagat gatgctcctt gatgctgctg     3840

tctatggctt actcgcttgg taccttgatc aggtgtttcc aggagactat ggaaccccac     3900

ttccttggta ctttcttcta caagagtcgt attggcttgg cggtgaaggg tgttcaacca     3960

gagaagaaag agccctggaa aagaccgagc ccctaacaga ggaaacggag gatccagagc     4020

acccagaagg aatacacgac tccttctttg aacgtgagca tccagggtgg gttcctgggg     4080

tatgcgtgaa gaatctggta aagatttttg agccctgtgg ccggccagct gtggaccgtc     4140

tgaacatcac cttctacgag aaccagatca ccgcattcct gggccacaat ggagctggga     4200

aaaccaccac cttgtaagta tcaaggttac aagacaggtt taaggagacc aatagaaact     4260

gggcttgtcg agacagagaa gactcttgcg tttctcaatt gaggaacccc tagtgatgga     4320

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4380

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca g              4431


<210>  23
<211>  4536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'CMV NO INTRON ABCA4 OV

<400>  23
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatct tcaatattgg ccattagcca tattattcat tggttatata gcataaatca      240

atattggcta ttggccattg catacgttgt atctatatca taatatgtac atttatattg      300

gctcatgtcc aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat      360

caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg      420

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt      480

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac      540

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg      600

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact      660

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt      720

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc      780

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc      840

gtaataaccc cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata      900

taagcagagc tcggcggccg ccatgggctt cgtgagacag atacagcttt tgctctggaa      960

gaactggacc ctgcggaaaa ggcaaaagat tcgctttgtg gtggaactcg tgtggccttt     1020

atctttattt ctggtcttga tctggttaag gaatgccaac ccgctctaca gccatcatga     1080

atgccatttc cccaacaagg cgatgccctc agcaggaatg ctgccgtggc tccaggggat     1140

cttctgcaat gtgaacaatc cctgttttca aagccccacc ccaggagaat ctcctggaat     1200

tgtgtcaaac tataacaact ccatcttggc aagggtatat cgagattttc aagaactcct     1260

catgaatgca ccagagagcc agcaccttgg ccgtatttgg acagagctac acatcttgtc     1320

ccaattcatg gacaccctcc ggactcaccc ggagagaatt gcaggaagag gaattcgaat     1380

aagggatatc ttgaaagatg aagaaacact gacactattt ctcattaaaa acatcggcct     1440

gtctgactca gtggtctacc ttctgatcaa ctctcaagtc cgtccagagc agttcgctca     1500

tggagtcccg gacctggcgc tgaaggacat cgcctgcagc gaggccctcc tggagcgctt     1560

catcatcttc agccagagac gcggggcaaa gacggtgcgc tatgccctgt gctccctctc     1620

ccagggcacc ctacagtgga tagaagacac tctgtatgcc aacgtggact tcttcaagct     1680

cttccgtgtg cttcccacac tcctagacag ccgttctcaa ggtatcaatc tgagatcttg     1740

gggaggaata ttatctgata tgtcaccaag aattcaagag tttatccatc ggccgagtat     1800

gcaggacttg ctgtgggtga ccaggcccct catgcagaat ggtggtccag agacctttac     1860

aaagctgatg ggcatcctgt ctgacctcct gtgtggctac cccgagggag gtggctctcg     1920

ggtgctctcc ttcaactggt atgaagacaa taactataag gcctttctgg ggattgactc     1980

cacaaggaag gatcctatct attcttatga cagaagaaca acatcctttt gtaatgcatt     2040

gatccagagc ctggagtcaa atcctttaac caaaatcgct tggagggcgg caaagccttt     2100

gctgatggga aaaatcctgt acactcctga ttcacctgca gcacgaagga tactgaagaa     2160

tgccaactca acttttgaag aactggaaca cgttaggaag ttggtcaaag cctgggaaga     2220

agtagggccc cagatctggt acttctttga caacagcaca cagatgaaca tgatcagaga     2280

taccctgggg aacccaacag taaaagactt tttgaatagg cagcttggtg aagaaggtat     2340

tactgctgaa gccatcctaa acttcctcta caagggccct cgggaaagcc aggctgacga     2400

catggccaac ttcgactgga gggacatatt taacatcact gatcgcaccc tccgccttgt     2460

caatcaatac ctggagtgct tggtcctgga taagtttgaa agctacaatg atgaaactca     2520

gctcacccaa cgtgccctct ctctactgga ggaaaacatg ttctgggccg gagtggtatt     2580

ccctgacatg tatccctgga ccagctctct accaccccac gtgaagtata agatccgaat     2640

ggacatagac gtggtggaga aaaccaataa gattaaagac aggtattggg attctggtcc     2700

cagagctgat cccgtggaag atttccggta catctggggc gggtttgcct atctgcagga     2760

catggttgaa caggggatca caaggagcca ggtgcaggcg gaggctccag ttggaatcta     2820

cctccagcag atgccctacc cctgcttcgt ggacgattct ttcatgatca tcctgaaccg     2880

ctgtttccct atcttcatgg tgctggcatg gatctactct gtctccatga ctgtgaagag     2940

catcgtcttg gagaaggagt tgcgactgaa ggagaccttg aaaaatcagg gtgtctccaa     3000

tgcagtgatt tggtgtacct ggttcctgga cagcttctcc atcatgtcga tgagcatctt     3060

cctcctgacg atattcatca tgcatggaag aatcctacat tacagcgacc cattcatcct     3120

cttcctgttc ttgttggctt tctccactgc caccatcatg ctgtgctttc tgctcagcac     3180

cttcttctcc aaggccagtc tggcagcagc ctgtagtggt gtcatctatt tcaccctcta     3240

cctgccacac atcctgtgct tcgcctggca ggaccgcatg accgctgagc tgaagaaggc     3300

tgtgagctta ctgtctccgg tggcatttgg atttggcact gagtacctgg ttcgctttga     3360

agagcaaggc ctggggctgc agtggagcaa catcgggaac agtcccacgg aaggggacga     3420

attcagcttc ctgctgtcca tgcagatgat gctccttgat gctgctgtct atggcttact     3480

cgcttggtac cttgatcagg tgtttccagg agactatgga accccacttc cttggtactt     3540

tcttctacaa gagtcgtatt ggcttggcgg tgaagggtgt tcaaccagag aagaaagagc     3600

cctggaaaag accgagcccc taacagagga aacggaggat ccagagcacc cagaaggaat     3660

acacgactcc ttctttgaac gtgagcatcc agggtgggtt cctggggtat gcgtgaagaa     3720

tctggtaaag atttttgagc cctgtggccg gccagctgtg gaccgtctga acatcacctt     3780

ctacgagaac cagatcaccg cattcctggg ccacaatgga gctgggaaaa ccaccacctt     3840

gtccatcctg acgggtctgt tgccaccaac ctctgggact gtgctcgttg ggggaaggga     3900

cattgaaacc agcctggatg cagtccggca gagccttggc atgtgtccac agcacaacat     3960

cctgttccac cacctcacgg tggctgagca catgctgttc tatgcccagc tgaaaggaaa     4020

gtcccaggag gaggcccagc tggagatgga agccatgttg gaggacacag gcctccacca     4080

caagcggaat gaagaggctc aggacctatc aggtggcatg cagagaaagc tgtcggttgc     4140

cattgccttt gtgggagatg ccaaggtggt gattctggac gaacccacct ctggggtgga     4200

cccttactcg agacgctcaa tctgggatct gctcctgaag tatcgctcag gcagaaccat     4260

catcatgtcc actcaccaca tggacgaggc cgacctcctt ggggaccgca ttgccatcat     4320

tgcccaggga aggctctact gctcaggcac cccactcttc ctgaagaact gctttggcac     4380

aggcttgtac ttaaccttgg tgcgcaagga acccctagtg atggagttgg ccactccctc     4440

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     4500

tgcccgggcg gcctcagtga gcgagcgagc gcgcag                               4536


<210>  24
<211>  4167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'CMV NO INTRON ABCA4-AK

<400>  24
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatct tcaatattgg ccattagcca tattattcat tggttatata gcataaatca      240

atattggcta ttggccattg catacgttgt atctatatca taatatgtac atttatattg      300

gctcatgtcc aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat      360

caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg      420

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt      480

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac      540

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg      600

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact      660

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt      720

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc      780

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc      840

gtaataaccc cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata      900

taagcagagc tcggcggccg ccatgggctt cgtgagacag atacagcttt tgctctggaa      960

gaactggacc ctgcggaaaa ggcaaaagat tcgctttgtg gtggaactcg tgtggccttt     1020

atctttattt ctggtcttga tctggttaag gaatgccaac ccgctctaca gccatcatga     1080

atgccatttc cccaacaagg cgatgccctc agcaggaatg ctgccgtggc tccaggggat     1140

cttctgcaat gtgaacaatc cctgttttca aagccccacc ccaggagaat ctcctggaat     1200

tgtgtcaaac tataacaact ccatcttggc aagggtatat cgagattttc aagaactcct     1260

catgaatgca ccagagagcc agcaccttgg ccgtatttgg acagagctac acatcttgtc     1320

ccaattcatg gacaccctcc ggactcaccc ggagagaatt gcaggaagag gaattcgaat     1380

aagggatatc ttgaaagatg aagaaacact gacactattt ctcattaaaa acatcggcct     1440

gtctgactca gtggtctacc ttctgatcaa ctctcaagtc cgtccagagc agttcgctca     1500

tggagtcccg gacctggcgc tgaaggacat cgcctgcagc gaggccctcc tggagcgctt     1560

catcatcttc agccagagac gcggggcaaa gacggtgcgc tatgccctgt gctccctctc     1620

ccagggcacc ctacagtgga tagaagacac tctgtatgcc aacgtggact tcttcaagct     1680

cttccgtgtg cttcccacac tcctagacag ccgttctcaa ggtatcaatc tgagatcttg     1740

gggaggaata ttatctgata tgtcaccaag aattcaagag tttatccatc ggccgagtat     1800

gcaggacttg ctgtgggtga ccaggcccct catgcagaat ggtggtccag agacctttac     1860

aaagctgatg ggcatcctgt ctgacctcct gtgtggctac cccgagggag gtggctctcg     1920

ggtgctctcc ttcaactggt atgaagacaa taactataag gcctttctgg ggattgactc     1980

cacaaggaag gatcctatct attcttatga cagaagaaca acatcctttt gtaatgcatt     2040

gatccagagc ctggagtcaa atcctttaac caaaatcgct tggagggcgg caaagccttt     2100

gctgatggga aaaatcctgt acactcctga ttcacctgca gcacgaagga tactgaagaa     2160

tgccaactca acttttgaag aactggaaca cgttaggaag ttggtcaaag cctgggaaga     2220

agtagggccc cagatctggt acttctttga caacagcaca cagatgaaca tgatcagaga     2280

taccctgggg aacccaacag taaaagactt tttgaatagg cagcttggtg aagaaggtat     2340

tactgctgaa gccatcctaa acttcctcta caagggccct cgggaaagcc aggctgacga     2400

catggccaac ttcgactgga gggacatatt taacatcact gatcgcaccc tccgccttgt     2460

caatcaatac ctggagtgct tggtcctgga taagtttgaa agctacaatg atgaaactca     2520

gctcacccaa cgtgccctct ctctactgga ggaaaacatg ttctgggccg gagtggtatt     2580

ccctgacatg tatccctgga ccagctctct accaccccac gtgaagtata agatccgaat     2640

ggacatagac gtggtggaga aaaccaataa gattaaagac aggtattggg attctggtcc     2700

cagagctgat cccgtggaag atttccggta catctggggc gggtttgcct atctgcagga     2760

catggttgaa caggggatca caaggagcca ggtgcaggcg gaggctccag ttggaatcta     2820

cctccagcag atgccctacc cctgcttcgt ggacgattct ttcatgatca tcctgaaccg     2880

ctgtttccct atcttcatgg tgctggcatg gatctactct gtctccatga ctgtgaagag     2940

catcgtcttg gagaaggagt tgcgactgaa ggagaccttg aaaaatcagg gtgtctccaa     3000

tgcagtgatt tggtgtacct ggttcctgga cagcttctcc atcatgtcga tgagcatctt     3060

cctcctgacg atattcatca tgcatggaag aatcctacat tacagcgacc cattcatcct     3120

cttcctgttc ttgttggctt tctccactgc caccatcatg ctgtgctttc tgctcagcac     3180

cttcttctcc aaggccagtc tggcagcagc ctgtagtggt gtcatctatt tcaccctcta     3240

cctgccacac atcctgtgct tcgcctggca ggaccgcatg accgctgagc tgaagaaggc     3300

tgtgagctta ctgtctccgg tggcatttgg atttggcact gagtacctgg ttcgctttga     3360

agagcaaggc ctggggctgc agtggagcaa catcgggaac agtcccacgg aaggggacga     3420

attcagcttc ctgctgtcca tgcagatgat gctccttgat gctgctgtct atggcttact     3480

cgcttggtac cttgatcagg tgtttccagg agactatgga accccacttc cttggtactt     3540

tcttctacaa gagtcgtatt ggcttggcgg tgaagggtgt tcaaccagag aagaaagagc     3600

cctggaaaag accgagcccc taacagagga aacggaggat ccagagcacc cagaaggaat     3660

acacgactcc ttctttgaac gtgagcatcc agggtgggtt cctggggtat gcgtgaagaa     3720

tctggtaaag atttttgagc cctgtggccg gccagctgtg gaccgtctga acatcacctt     3780

ctacgagaac cagatcaccg cattcctggg ccacaatgga gctgggaaaa ccaccacctt     3840

gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga     3900

cagagaagac tcttgcgttt ctgggatttt tccgatttcg gcctattggt taaaaaatga     3960

gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgttta taatttcagg     4020

tggcatcttt ccaattgagg aacccctagt gatggagttg gccactccct ctctgcgcgc     4080

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     4140

ggcctcagtg agcgagcgag cgcgcag                                         4167


<210>  25
<211>  4289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'VMD2 ABCA4-AK

<400>  25
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatct tcaatattgg ccattagcca tattattcat tggttatata gcataaatca      240

atattggcta ttggccattg catacgttgt atctatatca taatatgtac atttatattg      300

gctcatgtcc aatatgaccg ccatgttggc attgattatt gactagtaac ggccgccagt      360

gtgctggaat tcgcccttaa taacttaagc gtcagcatat gcagaattct gtcattttac      420

tagggtgatg aaattcccaa gcaacaccat ccttttcaga taagggcact gaggctgaga      480

gaggagctga aacctacccg gggtcaccac acacaggtgg caaggctggg accagaaacc      540

aggactgttg actgcagccc ggtattcatt ctttccatag cccacagggc tgtcaaagac      600

cccagggcct agtcagaggc tcctccttcc tggagagttc ctggcacaga agttgaagct      660

cagcacagcc ccctaacccc caactctctc tgcaaggcct caggggtcag aacactggtg      720

gagcagatcc tttagcctct ggattttagg gccatggtag agggggtgtt gccctaaatt      780

ccagccctgg tctcagccca acaccctcca agaagaaatt agaggggcca tggccaggct      840

gtgctagccg ttgcttctga gcagattaca agaagggact aagacaagga ctcctttgtg      900

gaggtcctgg cttagggagt caagtgacgg cggctcagca ctcacgtggg cagtgccagc      960

ctctaagagt gggcaggggc actggccaca gagtcccagg gagtcccacc agcctagtcg     1020

ccagaccttc tgtgggcggc cgccatgggc ttcgtgagac agatacagct tttgctctgg     1080

aagaactgga ccctgcggaa aaggcaaaag attcgctttg tggtggaact cgtgtggcct     1140

ttatctttat ttctggtctt gatctggtta aggaatgcca acccgctcta cagccatcat     1200

gaatgccatt tccccaacaa ggcgatgccc tcagcaggaa tgctgccgtg gctccagggg     1260

atcttctgca atgtgaacaa tccctgtttt caaagcccca ccccaggaga atctcctgga     1320

attgtgtcaa actataacaa ctccatcttg gcaagggtat atcgagattt tcaagaactc     1380

ctcatgaatg caccagagag ccagcacctt ggccgtattt ggacagagct acacatcttg     1440

tcccaattca tggacaccct ccggactcac ccggagagaa ttgcaggaag aggaattcga     1500

ataagggata tcttgaaaga tgaagaaaca ctgacactat ttctcattaa aaacatcggc     1560

ctgtctgact cagtggtcta ccttctgatc aactctcaag tccgtccaga gcagttcgct     1620

catggagtcc cggacctggc gctgaaggac atcgcctgca gcgaggccct cctggagcgc     1680

ttcatcatct tcagccagag acgcggggca aagacggtgc gctatgccct gtgctccctc     1740

tcccagggca ccctacagtg gatagaagac actctgtatg ccaacgtgga cttcttcaag     1800

ctcttccgtg tgcttcccac actcctagac agccgttctc aaggtatcaa tctgagatct     1860

tggggaggaa tattatctga tatgtcacca agaattcaag agtttatcca tcggccgagt     1920

atgcaggact tgctgtgggt gaccaggccc ctcatgcaga atggtggtcc agagaccttt     1980

acaaagctga tgggcatcct gtctgacctc ctgtgtggct accccgaggg aggtggctct     2040

cgggtgctct ccttcaactg gtatgaagac aataactata aggcctttct ggggattgac     2100

tccacaagga aggatcctat ctattcttat gacagaagaa caacatcctt ttgtaatgca     2160

ttgatccaga gcctggagtc aaatccttta accaaaatcg cttggagggc ggcaaagcct     2220

ttgctgatgg gaaaaatcct gtacactcct gattcacctg cagcacgaag gatactgaag     2280

aatgccaact caacttttga agaactggaa cacgttagga agttggtcaa agcctgggaa     2340

gaagtagggc cccagatctg gtacttcttt gacaacagca cacagatgaa catgatcaga     2400

gataccctgg ggaacccaac agtaaaagac tttttgaata ggcagcttgg tgaagaaggt     2460

attactgctg aagccatcct aaacttcctc tacaagggcc ctcgggaaag ccaggctgac     2520

gacatggcca acttcgactg gagggacata tttaacatca ctgatcgcac cctccgcctt     2580

gtcaatcaat acctggagtg cttggtcctg gataagtttg aaagctacaa tgatgaaact     2640

cagctcaccc aacgtgccct ctctctactg gaggaaaaca tgttctgggc cggagtggta     2700

ttccctgaca tgtatccctg gaccagctct ctaccacccc acgtgaagta taagatccga     2760

atggacatag acgtggtgga gaaaaccaat aagattaaag acaggtattg ggattctggt     2820

cccagagctg atcccgtgga agatttccgg tacatctggg gcgggtttgc ctatctgcag     2880

gacatggttg aacaggggat cacaaggagc caggtgcagg cggaggctcc agttggaatc     2940

tacctccagc agatgcccta cccctgcttc gtggacgatt ctttcatgat catcctgaac     3000

cgctgtttcc ctatcttcat ggtgctggca tggatctact ctgtctccat gactgtgaag     3060

agcatcgtct tggagaagga gttgcgactg aaggagacct tgaaaaatca gggtgtctcc     3120

aatgcagtga tttggtgtac ctggttcctg gacagcttct ccatcatgtc gatgagcatc     3180

ttcctcctga cgatattcat catgcatgga agaatcctac attacagcga cccattcatc     3240

ctcttcctgt tcttgttggc tttctccact gccaccatca tgctgtgctt tctgctcagc     3300

accttcttct ccaaggccag tctggcagca gcctgtagtg gtgtcatcta tttcaccctc     3360

tacctgccac acatcctgtg cttcgcctgg caggaccgca tgaccgctga gctgaagaag     3420

gctgtgagct tactgtctcc ggtggcattt ggatttggca ctgagtacct ggttcgcttt     3480

gaagagcaag gcctggggct gcagtggagc aacatcggga acagtcccac ggaaggggac     3540

gaattcagct tcctgctgtc catgcagatg atgctccttg atgctgctgt ctatggctta     3600

ctcgcttggt accttgatca ggtgtttcca ggagactatg gaaccccact tccttggtac     3660

tttcttctac aagagtcgta ttggcttggc ggtgaagggt gttcaaccag agaagaaaga     3720

gccctggaaa agaccgagcc cctaacagag gaaacggagg atccagagca cccagaagga     3780

atacacgact ccttctttga acgtgagcat ccagggtggg ttcctggggt atgcgtgaag     3840

aatctggtaa agatttttga gccctgtggc cggccagctg tggaccgtct gaacatcacc     3900

ttctacgaga accagatcac cgcattcctg ggccacaatg gagctgggaa aaccaccacc     3960

ttgtaagtat caaggttaca agacaggttt aaggagacca atagaaactg ggcttgtcga     4020

gacagagaag actcttgcgt ttctgggatt tttccgattt cggcctattg gttaaaaaat     4080

gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tataatttca     4140

ggtggcatct ttccaattga ggaaccccta gtgatggagt tggccactcc ctctctgcgc     4200

gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg     4260

gcggcctcag tgagcgagcg agcgcgcag                                       4289


<210>  26
<211>  4436
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'RHOABCA4-AK

<400>  26
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatct tcaatattgg ccattagcca tattattcat tggttatata gcataaatca      240

atattggcta ttggccattg catacgttgt atctatatca taatatgtac atttatattg      300

gctcatgtcc aatatgaccg ccatgttggc attgattatt gactagcaga tcttccccac      360

ctagccacct ggcaaactgc tccttctctc aaaggcccaa acatggcctc ccagactgca      420

acccccaggc agtcaggccc tgtctccaca acctcacagc caccctggac ggaatctgct      480

tcttcccaca tttgagtcct cctcagcccc tgagctcctc tgggcagggc tgtttctttc      540

catctttgta ttcccagggg cctgcaaata aatgtttaat gaacgaacaa gagagtgaat      600

tccaattcca tgcaacaagg attgggctcc tgggccctag gctatgtgtc tggcaccaga      660

aacggaagct gcaggttgca gcccctgccc tcatggagct cctcctgtca gaggagtgtg      720

gggactggat gactccagag gtaacttgtg ggggaacgaa caggtaaggg gctgtgtgac      780

gagatgagag actgggagaa taaaccagaa agtctctagc tgtccagagg acatagcaca      840

gaggcccatg gtccctattt caaacccagg ccaccagact gagctgggac cttgggacag      900

acaagtcatg cagaagttag gggaccttct cctccctttt cctggatcct gagtacctct      960

cctccctgac ctcaggcttc ctcctagtgt caccttggcc cctcttagaa gccaattagg     1020

ccctcagttt ctgcagcggg gattaatatg attatgaaca cccccaatct cccagatgct     1080

gattcagcca ggagcttagg agggggaggt cactttataa gggtctgggg gggtcagaac     1140

ccagagtcat ccgcctgaat tctgcagata tccatcacac tggcggccgc catgggcttc     1200

gtgagacaga tacagctttt gctctggaag aactggaccc tgcggaaaag gcaaaagatt     1260

cgctttgtgg tggaactcgt gtggccttta tctttatttc tggtcttgat ctggttaagg     1320

aatgccaacc cgctctacag ccatcatgaa tgccatttcc ccaacaaggc gatgccctca     1380

gcaggaatgc tgccgtggct ccaggggatc ttctgcaatg tgaacaatcc ctgttttcaa     1440

agccccaccc caggagaatc tcctggaatt gtgtcaaact ataacaactc catcttggca     1500

agggtatatc gagattttca agaactcctc atgaatgcac cagagagcca gcaccttggc     1560

cgtatttgga cagagctaca catcttgtcc caattcatgg acaccctccg gactcacccg     1620

gagagaattg caggaagagg aattcgaata agggatatct tgaaagatga agaaacactg     1680

acactatttc tcattaaaaa catcggcctg tctgactcag tggtctacct tctgatcaac     1740

tctcaagtcc gtccagagca gttcgctcat ggagtcccgg acctggcgct gaaggacatc     1800

gcctgcagcg aggccctcct ggagcgcttc atcatcttca gccagagacg cggggcaaag     1860

acggtgcgct atgccctgtg ctccctctcc cagggcaccc tacagtggat agaagacact     1920

ctgtatgcca acgtggactt cttcaagctc ttccgtgtgc ttcccacact cctagacagc     1980

cgttctcaag gtatcaatct gagatcttgg ggaggaatat tatctgatat gtcaccaaga     2040

attcaagagt ttatccatcg gccgagtatg caggacttgc tgtgggtgac caggcccctc     2100

atgcagaatg gtggtccaga gacctttaca aagctgatgg gcatcctgtc tgacctcctg     2160

tgtggctacc ccgagggagg tggctctcgg gtgctctcct tcaactggta tgaagacaat     2220

aactataagg cctttctggg gattgactcc acaaggaagg atcctatcta ttcttatgac     2280

agaagaacaa catccttttg taatgcattg atccagagcc tggagtcaaa tcctttaacc     2340

aaaatcgctt ggagggcggc aaagcctttg ctgatgggaa aaatcctgta cactcctgat     2400

tcacctgcag cacgaaggat actgaagaat gccaactcaa cttttgaaga actggaacac     2460

gttaggaagt tggtcaaagc ctgggaagaa gtagggcccc agatctggta cttctttgac     2520

aacagcacac agatgaacat gatcagagat accctgggga acccaacagt aaaagacttt     2580

ttgaataggc agcttggtga agaaggtatt actgctgaag ccatcctaaa cttcctctac     2640

aagggccctc gggaaagcca ggctgacgac atggccaact tcgactggag ggacatattt     2700

aacatcactg atcgcaccct ccgccttgtc aatcaatacc tggagtgctt ggtcctggat     2760

aagtttgaaa gctacaatga tgaaactcag ctcacccaac gtgccctctc tctactggag     2820

gaaaacatgt tctgggccgg agtggtattc cctgacatgt atccctggac cagctctcta     2880

ccaccccacg tgaagtataa gatccgaatg gacatagacg tggtggagaa aaccaataag     2940

attaaagaca ggtattggga ttctggtccc agagctgatc ccgtggaaga tttccggtac     3000

atctggggcg ggtttgccta tctgcaggac atggttgaac aggggatcac aaggagccag     3060

gtgcaggcgg aggctccagt tggaatctac ctccagcaga tgccctaccc ctgcttcgtg     3120

gacgattctt tcatgatcat cctgaaccgc tgtttcccta tcttcatggt gctggcatgg     3180

atctactctg tctccatgac tgtgaagagc atcgtcttgg agaaggagtt gcgactgaag     3240

gagaccttga aaaatcaggg tgtctccaat gcagtgattt ggtgtacctg gttcctggac     3300

agcttctcca tcatgtcgat gagcatcttc ctcctgacga tattcatcat gcatggaaga     3360

atcctacatt acagcgaccc attcatcctc ttcctgttct tgttggcttt ctccactgcc     3420

accatcatgc tgtgctttct gctcagcacc ttcttctcca aggccagtct ggcagcagcc     3480

tgtagtggtg tcatctattt caccctctac ctgccacaca tcctgtgctt cgcctggcag     3540

gaccgcatga ccgctgagct gaagaaggct gtgagcttac tgtctccggt ggcatttgga     3600

tttggcactg agtacctggt tcgctttgaa gagcaaggcc tggggctgca gtggagcaac     3660

atcgggaaca gtcccacgga aggggacgaa ttcagcttcc tgctgtccat gcagatgatg     3720

ctccttgatg ctgctgtcta tggcttactc gcttggtacc ttgatcaggt gtttccagga     3780

gactatggaa ccccacttcc ttggtacttt cttctacaag agtcgtattg gcttggcggt     3840

gaagggtgtt caaccagaga agaaagagcc ctggaaaaga ccgagcccct aacagaggaa     3900

acggaggatc cagagcaccc agaaggaata cacgactcct tctttgaacg tgagcatcca     3960

gggtgggttc ctggggtatg cgtgaagaat ctggtaaaga tttttgagcc ctgtggccgg     4020

ccagctgtgg accgtctgaa catcaccttc tacgagaacc agatcaccgc attcctgggc     4080

cacaatggag ctgggaaaac caccaccttg taagtatcaa ggttacaaga caggtttaag     4140

gagaccaata gaaactgggc ttgtcgagac agagaagact cttgcgtttc tgggattttt     4200

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt     4260

aacaaaatat taacgtttat aatttcaggt ggcatctttc caattgagga acccctagtg     4320

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag     4380

gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcag         4436


<210>  27
<211>  4327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'RHO ABCA4-TS

<400>  27
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatct tcaatattgg ccattagcca tattattcat tggttatata gcataaatca      240

atattggcta ttggccattg catacgttgt atctatatca taatatgtac atttatattg      300

gctcatgtcc aatatgaccg ccatgttggc attgattatt gactagcaga tcttccccac      360

ctagccacct ggcaaactgc tccttctctc aaaggcccaa acatggcctc ccagactgca      420

acccccaggc agtcaggccc tgtctccaca acctcacagc caccctggac ggaatctgct      480

tcttcccaca tttgagtcct cctcagcccc tgagctcctc tgggcagggc tgtttctttc      540

catctttgta ttcccagggg cctgcaaata aatgtttaat gaacgaacaa gagagtgaat      600

tccaattcca tgcaacaagg attgggctcc tgggccctag gctatgtgtc tggcaccaga      660

aacggaagct gcaggttgca gcccctgccc tcatggagct cctcctgtca gaggagtgtg      720

gggactggat gactccagag gtaacttgtg ggggaacgaa caggtaaggg gctgtgtgac      780

gagatgagag actgggagaa taaaccagaa agtctctagc tgtccagagg acatagcaca      840

gaggcccatg gtccctattt caaacccagg ccaccagact gagctgggac cttgggacag      900

acaagtcatg cagaagttag gggaccttct cctccctttt cctggatcct gagtacctct      960

cctccctgac ctcaggcttc ctcctagtgt caccttggcc cctcttagaa gccaattagg     1020

ccctcagttt ctgcagcggg gattaatatg attatgaaca cccccaatct cccagatgct     1080

gattcagcca ggagcttagg agggggaggt cactttataa gggtctgggg gggtcagaac     1140

ccagagtcat ccgcctgaat tctgcagata tccatcacac tggcggccgc catgggcttc     1200

gtgagacaga tacagctttt gctctggaag aactggaccc tgcggaaaag gcaaaagatt     1260

cgctttgtgg tggaactcgt gtggccttta tctttatttc tggtcttgat ctggttaagg     1320

aatgccaacc cgctctacag ccatcatgaa tgccatttcc ccaacaaggc gatgccctca     1380

gcaggaatgc tgccgtggct ccaggggatc ttctgcaatg tgaacaatcc ctgttttcaa     1440

agccccaccc caggagaatc tcctggaatt gtgtcaaact ataacaactc catcttggca     1500

agggtatatc gagattttca agaactcctc atgaatgcac cagagagcca gcaccttggc     1560

cgtatttgga cagagctaca catcttgtcc caattcatgg acaccctccg gactcacccg     1620

gagagaattg caggaagagg aattcgaata agggatatct tgaaagatga agaaacactg     1680

acactatttc tcattaaaaa catcggcctg tctgactcag tggtctacct tctgatcaac     1740

tctcaagtcc gtccagagca gttcgctcat ggagtcccgg acctggcgct gaaggacatc     1800

gcctgcagcg aggccctcct ggagcgcttc atcatcttca gccagagacg cggggcaaag     1860

acggtgcgct atgccctgtg ctccctctcc cagggcaccc tacagtggat agaagacact     1920

ctgtatgcca acgtggactt cttcaagctc ttccgtgtgc ttcccacact cctagacagc     1980

cgttctcaag gtatcaatct gagatcttgg ggaggaatat tatctgatat gtcaccaaga     2040

attcaagagt ttatccatcg gccgagtatg caggacttgc tgtgggtgac caggcccctc     2100

atgcagaatg gtggtccaga gacctttaca aagctgatgg gcatcctgtc tgacctcctg     2160

tgtggctacc ccgagggagg tggctctcgg gtgctctcct tcaactggta tgaagacaat     2220

aactataagg cctttctggg gattgactcc acaaggaagg atcctatcta ttcttatgac     2280

agaagaacaa catccttttg taatgcattg atccagagcc tggagtcaaa tcctttaacc     2340

aaaatcgctt ggagggcggc aaagcctttg ctgatgggaa aaatcctgta cactcctgat     2400

tcacctgcag cacgaaggat actgaagaat gccaactcaa cttttgaaga actggaacac     2460

gttaggaagt tggtcaaagc ctgggaagaa gtagggcccc agatctggta cttctttgac     2520

aacagcacac agatgaacat gatcagagat accctgggga acccaacagt aaaagacttt     2580

ttgaataggc agcttggtga agaaggtatt actgctgaag ccatcctaaa cttcctctac     2640

aagggccctc gggaaagcca ggctgacgac atggccaact tcgactggag ggacatattt     2700

aacatcactg atcgcaccct ccgccttgtc aatcaatacc tggagtgctt ggtcctggat     2760

aagtttgaaa gctacaatga tgaaactcag ctcacccaac gtgccctctc tctactggag     2820

gaaaacatgt tctgggccgg agtggtattc cctgacatgt atccctggac cagctctcta     2880

ccaccccacg tgaagtataa gatccgaatg gacatagacg tggtggagaa aaccaataag     2940

attaaagaca ggtattggga ttctggtccc agagctgatc ccgtggaaga tttccggtac     3000

atctggggcg ggtttgccta tctgcaggac atggttgaac aggggatcac aaggagccag     3060

gtgcaggcgg aggctccagt tggaatctac ctccagcaga tgccctaccc ctgcttcgtg     3120

gacgattctt tcatgatcat cctgaaccgc tgtttcccta tcttcatggt gctggcatgg     3180

atctactctg tctccatgac tgtgaagagc atcgtcttgg agaaggagtt gcgactgaag     3240

gagaccttga aaaatcaggg tgtctccaat gcagtgattt ggtgtacctg gttcctggac     3300

agcttctcca tcatgtcgat gagcatcttc ctcctgacga tattcatcat gcatggaaga     3360

atcctacatt acagcgaccc attcatcctc ttcctgttct tgttggcttt ctccactgcc     3420

accatcatgc tgtgctttct gctcagcacc ttcttctcca aggccagtct ggcagcagcc     3480

tgtagtggtg tcatctattt caccctctac ctgccacaca tcctgtgctt cgcctggcag     3540

gaccgcatga ccgctgagct gaagaaggct gtgagcttac tgtctccggt ggcatttgga     3600

tttggcactg agtacctggt tcgctttgaa gagcaaggcc tggggctgca gtggagcaac     3660

atcgggaaca gtcccacgga aggggacgaa ttcagcttcc tgctgtccat gcagatgatg     3720

ctccttgatg ctgctgtcta tggcttactc gcttggtacc ttgatcaggt gtttccagga     3780

gactatggaa ccccacttcc ttggtacttt cttctacaag agtcgtattg gcttggcggt     3840

gaagggtgtt caaccagaga agaaagagcc ctggaaaaga ccgagcccct aacagaggaa     3900

acggaggatc cagagcaccc agaaggaata cacgactcct tctttgaacg tgagcatcca     3960

gggtgggttc ctggggtatg cgtgaagaat ctggtaaaga tttttgagcc ctgtggccgg     4020

ccagctgtgg accgtctgaa catcaccttc tacgagaacc agatcaccgc attcctgggc     4080

cacaatggag ctgggaaaac caccaccttg taagtatcaa ggttacaaga caggtttaag     4140

gagaccaata gaaactgggc ttgtcgagac agagaagact cttgcgtttc tcaattgagg     4200

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     4260

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     4320

cgcgcag                                                               4327


<210>  28
<211>  277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary CBA promoter

<400>  28
tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa       60

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      120

cgcgcgccag gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg      180

gcggcagcca atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg      240

cggcggccct ataaaaagcg aagcgcgcgg cgggcgg                               277


<210>  29
<211>  835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example rhodopsin (Rho) promoter

<400>  29
agatcttccc cacctagcca cctggcaaac tgctccttct ctcaaaggcc caaacatggc       60

ctcccagact gcaaccccca ggcagtcagg ccctgtctcc acaacctcac agccaccctg      120

gacggaatct gcttcttccc acatttgagt cctcctcagc ccctgagctc ctctgggcag      180

ggctgtttct ttccatcttt gtattcccag gggcctgcaa ataaatgttt aatgaacgaa      240

caagagagtg aattccaatt ccatgcaaca aggattgggc tcctgggccc taggctatgt      300

gtctggcacc agaaacggaa gctgcaggtt gcagcccctg ccctcatgga gctcctcctg      360

tcagaggagt gtggggactg gatgactcca gaggtaactt gtgggggaac gaacaggtaa      420

ggggctgtgt gacgagatga gagactggga gaataaacca gaaagtctct agctgtccag      480

aggacatagc acagaggccc atggtcccta tttcaaaccc aggccaccag actgagctgg      540

gaccttggga cagacaagtc atgcagaagt taggggacct tctcctccct tttcctggat      600

cctgagtacc tctcctccct gacctcaggc ttcctcctag tgtcaccttg gcccctctta      660

gaagccaatt aggccctcag tttctgcagc ggggattaat atgattatga acacccccaa      720

tctcccagat gctgattcag ccaggagctt aggaggggga ggtcacttta taagggtctg      780

ggggggtcag aacccagagt catccgcctg aattctgcag atatccatca cactg           835


<210>  30
<211>  688
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example vitelliform macular dystrophy 2 (VMD2) promoter

<400>  30
aacggccgcc agtgtgctgg aattcgccct taataactta agcgtcagca tatgcagaat       60

tctgtcattt tactagggtg atgaaattcc caagcaacac catccttttc agataagggc      120

actgaggctg agagaggagc tgaaacctac ccggggtcac cacacacagg tggcaaggct      180

gggaccagaa accaggactg ttgactgcag cccggtattc attctttcca tagcccacag      240

ggctgtcaaa gaccccaggg cctagtcaga ggctcctcct tcctggagag ttcctggcac      300

agaagttgaa gctcagcaca gccccctaac ccccaactct ctctgcaagg cctcaggggt      360

cagaacactg gtggagcaga tcctttagcc tctggatttt agggccatgg tagagggggt      420

gttgccctaa attccagccc tggtctcagc ccaacaccct ccaagaagaa attagagggg      480

ccatggccag gctgtgctag ccgttgcttc tgagcagatt acaagaaggg actaagacaa      540

ggactccttt gtggaggtcc tggcttaggg agtcaagtga cggcggctca gcactcacgt      600

gggcagtgcc agcctctaag agtgggcagg ggcactggcc acagagtccc agggagtccc      660

accagcctag tcgccagacc ttctgtgg                                         688


<210>  31
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wild-type small T antigen intron

<400>  31
taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt gtttgtgtat       60

tttag                                                                   65


<210>  32
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wild-type large T antigen intron

<400>  32
gtatttgctt cttccttaaa tcctggtgtt gatgcaatgt actgcaaaca atggcctgag       60

tgtgcaaaga aaatgtctgc taactgcata tgcttgctgt gcttactgag gatgaagcat      120

gaaaatagaa aattatacag gaaagatcca cttgtgtggg ttgattgcta ctgcttcgat      180

tgctttagaa tgtggtttgg acttgatctt tgtgaaggaa ccttacttct gtggtgtgac      240

ataattggac aaactaccta cagagattta aagctctaag gtaaatataa aatttttaag      300

tgtataatgt gttaaactac tgattctaat tgtttgtgta ttttag                     346


<210>  33
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 intron

<400>  33
ctctaaggta aatataaaat ttttaagtgt ataatgtgtt aaactactga ttctaattgt       60

ttgtgtattt tagattccaa cctatggaac tga                                    93


<210>  34
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary recombinogenic region sequence (AK)

<400>  34
gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac       60

gcgaatttta acaaaat                                                      77


<210>  35
<211>  278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AP

<400>  35
gtgatcctag gtggaggccg aaagtacatg tttcgcatgg gaaccccaga ccctgagtac       60

ccagatgact acagccaagg tgggaccagg ctggacggga agaatctggt gcaggaatgg      120

ctggcgaagc gccagggtgc ccggtacgtg tggaaccgca ctgagctcat gcaggcttcc      180

ctggacccgt ctgtgaccca tctcatgggt ctctttgagc ctggagacat gaaatacgag      240

atccaccgag actccacact ggacccctcc ctgatgga                              278


<210>  36
<211>  287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AP1

<400>  36
ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg       60

ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg      120

aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc      180

ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt      240

aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttc                    287


<210>  37
<211>  288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AP2

<400>  37
cgcagggcag cctctgtcat ctccatcagg gaggggtcca gtgtggagtc tcggtggatc       60

tcgtatttca tgtctccagg ctcaaagaga cccatgagat gggtcacaga cgggtccagg      120

gaagcctgca tgagctcagt gcggttccac acataccggg caccctggcg cttcgccagc      180

cattcctgca ccagattctt cccgtccagc ctggtcccac cttggctgta gtcatctggg      240

tactcagggt ctggggttcc catgcgaaac atgtactttc ggcctcca                   288


<210>  38
<211>  261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary polyadenylation sequence

<400>  38
ttcgagcaga catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt       60

gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa      120

gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg      180

agatgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtaaa atcgataagg      240

atcttcctag agcatggcta c                                                261


<210>  39
<211>  6648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example MYO7A nucleotide sequence

<400>  39
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggtatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

aacaagccca tgaacatcat ctccctcatc gatgaggaga gcaagttccc caagggcaca     1560

gacaccacca tgttacacaa gctgaactcc cagcacaagc tcaacgccaa ctacatcccc     1620

cccaagaaca accatgagac ccagtttggc atcaaccatt ttgcaggcat cgtctactat     1680

gagacccaag gcttcctgga gaagaaccga gacaccctgc atggggacat tatccagctg     1740

gtccactcct ccaggaacaa gttcatcaag cagatcttcc aggccgatgt cgccatgggc     1800

gccgagacca ggaagcgctc gcccacactt agcagccagt tcaagcggtc actggagctg     1860

ctgatgcgca cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa gcccaatgag     1920

ttcaagaagc ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg gtactcagga     1980

atgatggaga ccatccgaat ccgccgagct ggctacccca tccgctacag cttcgtagag     2040

tttgtggagc ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa gcagggcgac     2100

ctccgcggga cttgccagcg catggctgag gctgtgctgg gcacccacga tgactggcag     2160

ataggcaaaa ccaagatctt tctgaaggac caccatgaca tgctgctgga agtggagcgg     2220

gacaaagcca tcaccgacag agtcatcctc cttcagaaag tcatccgggg attcaaagac     2280

aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt     2340

cacaactgta ggaagaacta cgggctgatg cgtctgggct tcctgcggct gcaggccctg     2400

caccgctccc ggaagctgca ccagcagtac cgcctggccc gccagcgcat catccagttc     2460

caggcccgct gccgcgccta tctggtgcgc aaggccttcc gccaccgcct ctgggctgtg     2520

ctcaccgtgc aggcctatgc ccggggcatg atcgcccgca ggctgcacca acgcctcagg     2580

gctgagtatc tgtggcgcct cgaggctgag aaaatgcggc tggcggagga agagaagctt     2640

cggaaggaga tgagcgccaa gaaggccaag gaggaggccg agcgcaagca tcaggagcgc     2700

ctggcccagc tggctcgtga ggacgctgag cgggagctga aggagaagga ggccgctcgg     2760

cggaagaagg agctcctgga gcagatggaa agggcccgcc atgagcctgt caatcactca     2820

gacatggtgg acaagatgtt tggcttcctg gggacttcag gtggcctgcc aggccaggag     2880

ggccaggcac ctagtggctt tgaggacctg gagcgagggc ggagggagat ggtggaggag     2940

gacctggatg cagccctgcc cctgcctgac gaggatgagg aggacctctc tgagtataaa     3000

tttgccaagt tcgcggccac ctacttccag gggacaacca cgcactccta cacccggcgg     3060

ccactcaaac agccactgct ctaccatgac gacgagggtg accagctggc agccctggcg     3120

gtctggatca ccatcctccg cttcatgggg gacctccctg agcccaagta ccacacagcc     3180

atgagtgatg gcagtgagaa gatccctgtg atgaccaaga tttatgagac cctgggcaag     3240

aagacgtaca agagggagct gcaggccctg cagggcgagg gcgaggccca gctccccgag     3300

ggccagaaga agagcagtgt gaggcacaag ctggtgcatt tgactctgaa aaagaagtcc     3360

aagctcacag aggaggtgac caagaggctg catgacgggg agtccacagt gcagggcaac     3420

agcatgctgg aggaccggcc cacctccaac ctggagaagc tgcacttcat catcggcaat     3480

ggcatcctgc ggccagcact ccgggacgag atctactgcc agatcagcaa gcagctgacc     3540

cacaacccct ccaagagcag ctatgcccgg ggctggattc tcgtgtctct ctgcgtgggc     3600

tgtttcgccc cctccgagaa gtttgtcaag tacctgcgga acttcatcca cgggggcccg     3660

cccggctacg ccccgtactg tgaggagcgc ctgagaagga cctttgtcaa tgggacacgg     3720

acacagccgc ccagctggct ggagctgcag gccaccaagt ccaagaagcc aatcatgttg     3780

cccgtgacat tcatggatgg gaccaccaag accctgctga cggactcggc aaccacggcc     3840

aaggagctct gcaacgcgct ggccgacaag atctctctca aggaccggtt cgggttctcc     3900

ctctacattg ccctgtttga caaggtgtcc tccctgggca gcggcagtga ccacgtcatg     3960

gacgccatct cccagtgcga gcagtacgcc aaggagcagg gcgcccagga gcgcaacgcc     4020

ccctggaggc tcttcttccg caaagaggtc ttcacgccct ggcacagccc ctccgaggac     4080

aacgtggcca ccaacctcat ctaccagcag gtggtgcgag gagtcaagtt tggggagtac     4140

aggtgtgaga aggaggacga cctggctgag ctggcctccc agcagtactt tgtagactat     4200

ggctctgaga tgatcctgga gcgcctcctg aacctcgtgc ccacctacat ccccgaccgc     4260

gagatcacgc ccctgaagac gctggagaag tgggcccagc tggccatcgc cgcccacaag     4320

aaggggattt atgcccagag gagaactgat gcccagaagg tcaaagagga tgtggtcagt     4380

tatgcccgct tcaagtggcc cttgctcttc tccaggtttt atgaagccta caaattctca     4440

ggccccagtc tccccaagaa cgacgtcatc gtggccgtca actggacggg tgtgtacttt     4500

gtggatgagc aggagcaggt acttctggag ctgtccttcc cagagatcat ggccgtgtcc     4560

agcagcaggg agtgccgtgt ctggctctca ctgggctgct ctgatcttgg ctgtgctgcg     4620

cctcactcag gctgggcagg actgaccccg gcggggccct gttctccgtg ttggtcctgc     4680

aggggagcga aaacgacggc ccccagcttc acgctggcca ccatcaaggg ggacgaatac     4740

accttcacct ccagcaatgc tgaggacatt cgtgacctgg tggtcacctt cctagagggg     4800

ctccggaaga gatctaagta tgttgtggcc ctgcaggata accccaaccc cgcaggcgag     4860

gagtcaggct tcctcagctt tgccaaggga gacctcatca tcctggacca tgacacgggc     4920

gagcaggtca tgaactcggg ctgggccaac ggcatcaatg agaggaccaa gcagcgtggg     4980

gacttcccca ccgacagtgt gtacgtcatg cccactgtca ccatgccacc gcgggagatt     5040

gtggccctgg tcaccatgac tcccgatcag aggcaggacg ttgtccggct cttgcagctg     5100

cgaacggcgg agcccgaggt gcgtgccaag ccctacacgc tggaggagtt ttcctatgac     5160

tacttcaggc ccccacccaa gcacacgctg agccgtgtca tggtgtccaa ggcccgaggc     5220

aaggaccggc tgtggagcca cacgcgggaa ccgctcaagc aggcgctgct caagaagctc     5280

ctgggcagtg aggagctctc gcaggaggcc tgcctggcct tcattgctgt gctcaagtac     5340

atgggcgact acccgtccaa gaggacacgc tccgtcaacg agctcaccga ccagatcttt     5400

gagggtcccc tgaaagccga gcccctgaag gacgaggcat atgtgcagat cctgaagcag     5460

ctgaccgaca accacatcag gtacagcgag gagcggggtt gggagctgct ctggctgtgc     5520

acgggccttt tcccacccag caacatcctc ctgccccacg tgcagcgctt cctgcagtcc     5580

cgaaagcact gcccactcgc catcgactgc ctgcaacggc tccagaaagc cctgagaaac     5640

gggtcccgga agtaccctcc gcacctggtg gaggtggagg ccatccagca caagaccacc     5700

cagattttcc acaaagtcta cttccctgat gacactgacg aggccttcga agtggagtcc     5760

agcaccaagg ccaaggactt ctgccagaac atcgccacca ggctgctcct caagtcctca     5820

gagggattca gcctctttgt caaaattgca gacaaggtcc tcagcgttcc tgagaatgac     5880

ttcttctttg actttgttcg acacttgaca gactggataa agaaagctcg gcccatcaag     5940

gacggaattg tgccctcact cacctaccag gtgttcttca tgaagaagct gtggaccacc     6000

acggtgccag ggaaggatcc catggccgat tccatcttcc actattacca ggagttgccc     6060

aagtatctcc gaggctacca caagtgcacg cgggaggagg tgctgcagct gggggcgctg     6120

atctacaggg tcaagttcga ggaggacaag tcctacttcc ccagcatccc caagctgctg     6180

cgggagctgg tgccccagga ccttatccgg caggtctcac ctgatgactg gaagcggtcc     6240

atcgtcgcct acttcaacaa gcacgcaggg aagtccaagg aggaggccaa gctggccttc     6300

ctgaagctca tcttcaagtg gcccaccttt ggctcagcct tcttcgaggt gaagcaaact     6360

acggagccaa acttccctga gatcctccta attgccatca acaagtatgg ggtcagcctc     6420

atcgatccca aaacgaagga tatcctcacc actcatccct tcaccaagat ctccaactgg     6480

agcagcggca acacctactt ccacatcacc attgggaact tggtgcgcgg gagcaaactg     6540

ctctgcgaga cgtcactggg ctacaagatg gatgacctcc tgacttccta cattagccag     6600

atgctcacag ccatgagcaa acagcggggc tccaggagcg gcaagtga                  6648


<210>  40
<211>  3108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example 5' end portion of a MYO7A transgene

<400>  40
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggtatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

aacaagccca tgaacatcat ctccctcatc gatgaggaga gcaagttccc caagggcaca     1560

gacaccacca tgttacacaa gctgaactcc cagcacaagc tcaacgccaa ctacatcccc     1620

cccaagaaca accatgagac ccagtttggc atcaaccatt ttgcaggcat cgtctactat     1680

gagacccaag gcttcctgga gaagaaccga gacaccctgc atggggacat tatccagctg     1740

gtccactcct ccaggaacaa gttcatcaag cagatcttcc aggccgatgt cgccatgggc     1800

gccgagacca ggaagcgctc gcccacactt agcagccagt tcaagcggtc actggagctg     1860

ctgatgcgca cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa gcccaatgag     1920

ttcaagaagc ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg gtactcagga     1980

atgatggaga ccatccgaat ccgccgagct ggctacccca tccgctacag cttcgtagag     2040

tttgtggagc ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa gcagggcgac     2100

ctccgcggga cttgccagcg catggctgag gctgtgctgg gcacccacga tgactggcag     2160

ataggcaaaa ccaagatctt tctgaaggac caccatgaca tgctgctgga agtggagcgg     2220

gacaaagcca tcaccgacag agtcatcctc cttcagaaag tcatccgggg attcaaagac     2280

aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt     2340

cacaactgta ggaagaacta cgggctgatg cgtctgggct tcctgcggct gcaggccctg     2400

caccgctccc ggaagctgca ccagcagtac cgcctggccc gccagcgcat catccagttc     2460

caggcccgct gccgcgccta tctggtgcgc aaggccttcc gccaccgcct ctgggctgtg     2520

ctcaccgtgc aggcctatgc ccggggcatg atcgcccgca ggctgcacca acgcctcagg     2580

gctgagtatc tgtggcgcct cgaggctgag aaaatgcggc tggcggagga agagaagctt     2640

cggaaggaga tgagcgccaa gaaggccaag gaggaggccg agcgcaagca tcaggagcgc     2700

ctggcccagc tggctcgtga ggacgctgag cgggagctga aggagaagga ggccgctcgg     2760

cggaagaagg agctcctgga gcagatggaa agggcccgcc atgagcctgt caatcactca     2820

gacatggtgg acaagatgtt tggcttcctg gggacttcag gtggcctgcc aggccaggag     2880

ggccaggcac ctagtggctt tgaggacctg gagcgagggc ggagggagat ggtggaggag     2940

gacctggatg cagccctgcc cctgcctgac gaggatgagg aggacctctc tgagtataaa     3000

tttgccaagt tcgcggccac ctacttccag gggacaacca cgcactccta cacccggcgg     3060

ccactcaaac agccactgct ctaccatgac gacgagggtg accagctg                  3108


<210>  41
<211>  3540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example 3' end portion of a MYO7A transgene

<400>  41
gcagccctgg cggtctggat caccatcctc cgcttcatgg gggacctccc tgagcccaag       60

taccacacag ccatgagtga tggcagtgag aagatccctg tgatgaccaa gatttatgag      120

accctgggca agaagacgta caagagggag ctgcaggccc tgcagggcga gggcgaggcc      180

cagctccccg agggccagaa gaagagcagt gtgaggcaca agctggtgca tttgactctg      240

aaaaagaagt ccaagctcac agaggaggtg accaagaggc tgcatgacgg ggagtccaca      300

gtgcagggca acagcatgct ggaggaccgg cccacctcca acctggagaa gctgcacttc      360

atcatcggca atggcatcct gcggccagca ctccgggacg agatctactg ccagatcagc      420

aagcagctga cccacaaccc ctccaagagc agctatgccc ggggctggat tctcgtgtct      480

ctctgcgtgg gctgtttcgc cccctccgag aagtttgtca agtacctgcg gaacttcatc      540

cacgggggcc cgcccggcta cgccccgtac tgtgaggagc gcctgagaag gacctttgtc      600

aatgggacac ggacacagcc gcccagctgg ctggagctgc aggccaccaa gtccaagaag      660

ccaatcatgt tgcccgtgac attcatggat gggaccacca agaccctgct gacggactcg      720

gcaaccacgg ccaaggagct ctgcaacgcg ctggccgaca agatctctct caaggaccgg      780

ttcgggttct ccctctacat tgccctgttt gacaaggtgt cctccctggg cagcggcagt      840

gaccacgtca tggacgccat ctcccagtgc gagcagtacg ccaaggagca gggcgcccag      900

gagcgcaacg ccccctggag gctcttcttc cgcaaagagg tcttcacgcc ctggcacagc      960

ccctccgagg acaacgtggc caccaacctc atctaccagc aggtggtgcg aggagtcaag     1020

tttggggagt acaggtgtga gaaggaggac gacctggctg agctggcctc ccagcagtac     1080

tttgtagact atggctctga gatgatcctg gagcgcctcc tgaacctcgt gcccacctac     1140

atccccgacc gcgagatcac gcccctgaag acgctggaga agtgggccca gctggccatc     1200

gccgcccaca agaaggggat ttatgcccag aggagaactg atgcccagaa ggtcaaagag     1260

gatgtggtca gttatgcccg cttcaagtgg cccttgctct tctccaggtt ttatgaagcc     1320

tacaaattct caggccccag tctccccaag aacgacgtca tcgtggccgt caactggacg     1380

ggtgtgtact ttgtggatga gcaggagcag gtacttctgg agctgtcctt cccagagatc     1440

atggccgtgt ccagcagcag ggagtgccgt gtctggctct cactgggctg ctctgatctt     1500

ggctgtgctg cgcctcactc aggctgggca ggactgaccc cggcggggcc ctgttctccg     1560

tgttggtcct gcaggggagc gaaaacgacg gcccccagct tcacgctggc caccatcaag     1620

ggggacgaat acaccttcac ctccagcaat gctgaggaca ttcgtgacct ggtggtcacc     1680

ttcctagagg ggctccggaa gagatctaag tatgttgtgg ccctgcagga taaccccaac     1740

cccgcaggcg aggagtcagg cttcctcagc tttgccaagg gagacctcat catcctggac     1800

catgacacgg gcgagcaggt catgaactcg ggctgggcca acggcatcaa tgagaggacc     1860

aagcagcgtg gggacttccc caccgacagt gtgtacgtca tgcccactgt caccatgcca     1920

ccgcgggaga ttgtggccct ggtcaccatg actcccgatc agaggcagga cgttgtccgg     1980

ctcttgcagc tgcgaacggc ggagcccgag gtgcgtgcca agccctacac gctggaggag     2040

ttttcctatg actacttcag gcccccaccc aagcacacgc tgagccgtgt catggtgtcc     2100

aaggcccgag gcaaggaccg gctgtggagc cacacgcggg aaccgctcaa gcaggcgctg     2160

ctcaagaagc tcctgggcag tgaggagctc tcgcaggagg cctgcctggc cttcattgct     2220

gtgctcaagt acatgggcga ctacccgtcc aagaggacac gctccgtcaa cgagctcacc     2280

gaccagatct ttgagggtcc cctgaaagcc gagcccctga aggacgaggc atatgtgcag     2340

atcctgaagc agctgaccga caaccacatc aggtacagcg aggagcgggg ttgggagctg     2400

ctctggctgt gcacgggcct tttcccaccc agcaacatcc tcctgcccca cgtgcagcgc     2460

ttcctgcagt cccgaaagca ctgcccactc gccatcgact gcctgcaacg gctccagaaa     2520

gccctgagaa acgggtcccg gaagtaccct ccgcacctgg tggaggtgga ggccatccag     2580

cacaagacca cccagatttt ccacaaagtc tacttccctg atgacactga cgaggccttc     2640

gaagtggagt ccagcaccaa ggccaaggac ttctgccaga acatcgccac caggctgctc     2700

ctcaagtcct cagagggatt cagcctcttt gtcaaaattg cagacaaggt cctcagcgtt     2760

cctgagaatg acttcttctt tgactttgtt cgacacttga cagactggat aaagaaagct     2820

cggcccatca aggacggaat tgtgccctca ctcacctacc aggtgttctt catgaagaag     2880

ctgtggacca ccacggtgcc agggaaggat cccatggccg attccatctt ccactattac     2940

caggagttgc ccaagtatct ccgaggctac cacaagtgca cgcgggagga ggtgctgcag     3000

ctgggggcgc tgatctacag ggtcaagttc gaggaggaca agtcctactt ccccagcatc     3060

cccaagctgc tgcgggagct ggtgccccag gaccttatcc ggcaggtctc acctgatgac     3120

tggaagcggt ccatcgtcgc ctacttcaac aagcacgcag ggaagtccaa ggaggaggcc     3180

aagctggcct tcctgaagct catcttcaag tggcccacct ttggctcagc cttcttcgag     3240

gtgaagcaaa ctacggagcc aaacttccct gagatcctcc taattgccat caacaagtat     3300

ggggtcagcc tcatcgatcc caaaacgaag gatatcctca ccactcatcc cttcaccaag     3360

atctccaact ggagcagcgg caacacctac ttccacatca ccattgggaa cttggtgcgc     3420

gggagcaaac tgctctgcga gacgtcactg ggctacaaga tggatgacct cctgacttcc     3480

tacattagcc agatgctcac agccatgagc aaacagcggg gctccaggag cggcaagtga     3540


<210>  42
<211>  6822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example ABCA4 nucleotide sequence

<400>  42
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc gctctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga attcgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct tcccacactc      780

ctagacagcc gttctcaagg tatcaatctg agatcttggg gaggaatatt atctgatatg      840

tcaccaagaa ttcaagagtt tatccatcgg ccgagtatgc aggacttgct gtgggtgacc      900

aggcccctca tgcagaatgg tggtccagag acctttacaa agctgatggg catcctgtct      960

gacctcctgt gtggctaccc cgagggaggt ggctctcggg tgctctcctt caactggtat     1020

gaagacaata actataaggc ctttctgggg attgactcca caaggaagga tcctatctat     1080

tcttatgaca gaagaacaac atccttttgt aatgcattga tccagagcct ggagtcaaat     1140

cctttaacca aaatcgcttg gagggcggca aagcctttgc tgatgggaaa aatcctgtac     1200

actcctgatt cacctgcagc acgaaggata ctgaagaatg ccaactcaac ttttgaagaa     1260

ctggaacacg ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca gatctggtac     1320

ttctttgaca acagcacaca gatgaacatg atcagagata ccctggggaa cccaacagta     1380

aaagactttt tgaataggca gcttggtgaa gaaggtatta ctgctgaagc catcctaaac     1440

ttcctctaca agggccctcg ggaaagccag gctgacgaca tggccaactt cgactggagg     1500

gacatattta acatcactga tcgcaccctc cgccttgtca atcaatacct ggagtgcttg     1560

gtcctggata agtttgaaag ctacaatgat gaaactcagc tcacccaacg tgccctctct     1620

ctactggagg aaaacatgtt ctgggccgga gtggtattcc ctgacatgta tccctggacc     1680

agctctctac caccccacgt gaagtataag atccgaatgg acatagacgt ggtggagaaa     1740

accaataaga ttaaagacag gtattgggat tctggtccca gagctgatcc cgtggaagat     1800

ttccggtaca tctggggcgg gtttgcctat ctgcaggaca tggttgaaca ggggatcaca     1860

aggagccagg tgcaggcgga ggctccagtt ggaatctacc tccagcagat gccctacccc     1920

tgcttcgtgg acgattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg     1980

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg     2040

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg     2100

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg     2160

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     2220

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     2280

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     2340

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     2400

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     2460

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     2520

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     2580

tttccaggag actatggaac cccacttcct tggtactttc ttctacaaga gtcgtattgg     2640

cttggcggtg aagggtgttc aaccagagaa gaaagagccc tggaaaagac cgagccccta     2700

acagaggaaa cggaggatcc agagcaccca gaaggaatac acgactcctt ctttgaacgt     2760

gagcatccag ggtgggttcc tggggtatgc gtgaagaatc tggtaaagat ttttgagccc     2820

tgtggccggc cagctgtgga ccgtctgaac atcaccttct acgagaacca gatcaccgca     2880

ttcctgggcc acaatggagc tgggaaaacc accaccttgt ccatcctgac gggtctgttg     2940

ccaccaacct ctgggactgt gctcgttggg ggaagggaca ttgaaaccag cctggatgca     3000

gtccggcaga gccttggcat gtgtccacag cacaacatcc tgttccacca cctcacggtg     3060

gctgagcaca tgctgttcta tgcccagctg aaaggaaagt cccaggagga ggcccagctg     3120

gagatggaag ccatgttgga ggacacaggc ctccaccaca agcggaatga agaggctcag     3180

gacctatcag gtggcatgca gagaaagctg tcggttgcca ttgcctttgt gggagatgcc     3240

aaggtggtga ttctggacga acccacctct ggggtggacc cttactcgag acgctcaatc     3300

tgggatctgc tcctgaagta tcgctcaggc agaaccatca tcatgtccac tcaccacatg     3360

gacgaggccg acctccttgg ggaccgcatt gccatcattg cccagggaag gctctactgc     3420

tcaggcaccc cactcttcct gaagaactgc tttggcacag gcttgtactt aaccttggtg     3480

cgcaagatga aaaacatcca gagccaaagg aaaggcagtg aggggacctg cagctgctcg     3540

tctaagggtt tctccaccac gtgtccagcc cacgtcgatg acctaactcc agaacaagtc     3600

ctggatgggg atgtaaatga gctgatggat gtagttctcc accatgttcc agaggcaaag     3660

ctggtggagt gcattggtca agaacttatc ttccttcttc caaataagaa cttcaagcac     3720

agagcatatg ccagcctttt cagagagctg gaggagacgc tggctgacct tggtctcagc     3780

agttttggaa tttctgacac tcccctggaa gagatttttc tgaaggtcac ggaggattct     3840

gattcaggac ctctgtttgc gggtggcgct cagcagaaaa gagaaaacgt caacccccga     3900

cacccctgct tgggtcccag agagaaggct ggacagacac cccaggactc caatgtctgc     3960

tccccagggg cgccggctgc tcacccagag ggccagcctc ccccagagcc agagtgccca     4020

ggcccgcagc tcaacacggg gacacagctg gtcctccagc atgtgcaggc gctgctggtc     4080

aagagattcc aacacaccat ccgcagccac aaggacttcc tggcgcagat cgtgctcccg     4140

gctacctttg tgtttttggc tctgatgctt tctattgtta tccctccttt tggcgaatac     4200

cccgctttga cccttcaccc ctggatatat gggcagcagt acaccttctt cagcatggat     4260

gaaccaggca gtgagcagtt cacggtactt gcagacgtcc tcctgaataa gccaggcttt     4320

ggcaaccgct gcctgaagga agggtggctt ccggagtacc cctgtggcaa ctcaacaccc     4380

tggaagactc cttctgtgtc cccaaacatc acccagctgt tccagaagca gaaatggaca     4440

caggtcaacc cttcaccatc ctgcaggtgc agcaccaggg agaagctcac catgctgcca     4500

gagtgccccg agggtgccgg gggcctcccg cccccccaga gaacacagcg cagcacggaa     4560

attctacaag acctgacgga caggaacatc tccgacttct tggtaaaaac gtatcctgct     4620

cttataagaa gcagcttaaa gagcaaattc tgggtcaatg aacagaggta tggaggaatt     4680

tccattggag gaaagctccc agtcgtcccc atcacggggg aagcacttgt tgggttttta     4740

agcgaccttg gccggatcat gaatgtgagc gggggcccta tcactagaga ggcctctaaa     4800

gaaatacctg atttccttaa acatctagaa actgaagaca acattaaggt gtggtttaat     4860

aacaaaggct ggcatgccct ggtcagcttt ctcaatgtgg cccacaacgc catcttacgg     4920

gccagcctgc ctaaggacag aagccccgag gagtatggaa tcaccgtcat tagccaaccc     4980

ctgaacctga ccaaggagca gctctcagag attacagtgc tgaccacttc agtggatgct     5040

gtggttgcca tctgcgtgat tttctccatg tccttcgtcc cagccagctt tgtcctttat     5100

ttgatccagg agcgggtgaa caaatccaag cacctccagt ttatcagtgg agtgagcccc     5160

accacctact gggtaaccaa cttcctctgg gacatcatga attattccgt gagtgctggg     5220

ctggtggtgg gcatcttcat cgggtttcag aagaaagcct acacttctcc agaaaacctt     5280

cctgcccttg tggcactgct cctgctgtat ggatgggcgg tcattcccat gatgtaccca     5340

gcatccttcc tgtttgatgt ccccagcaca gcctatgtgg ctttatcttg tgctaatctg     5400

ttcatcggca tcaacagcag tgctattacc ttcatcttgg aattatttga gaataaccgg     5460

acgctgctca ggttcaacgc cgtgctgagg aagctgctca ttgtcttccc ccacttctgc     5520

ctgggccggg gcctcattga ccttgcactg agccaggctg tgacagatgt ctatgcccgg     5580

tttggtgagg agcactctgc aaatccgttc cactgggacc tgattgggaa gaacctgttt     5640

gccatggtgg tggaaggggt ggtgtacttc ctcctgaccc tgctggtcca gcgccacttc     5700

ttcctctccc aatggattgc cgagcccact aaggagccca ttgttgatga agatgatgat     5760

gtggctgaag aaagacaaag aattattact ggtggaaata aaactgacat cttaaggcta     5820

catgaactaa ccaagattta tccaggcacc tccagcccag cagtggacag gctgtgtgtc     5880

ggagttcgcc ctggagagtg ctttggcctc ctgggagtga atggtgccgg caaaacaacc     5940

acattcaaga tgctcactgg ggacaccaca gtgacctcag gggatgccac cgtagcaggc     6000

aagagtattt taaccaatat ttctgaagtc catcaaaata tgggctactg tcctcagttt     6060

gatgcaatcg atgagctgct cacaggacga gaacatcttt acctttatgc ccggcttcga     6120

ggtgtaccag cagaagaaat cgaaaaggtt gcaaactgga gtattaagag cctgggcctg     6180

actgtctacg ccgactgcct ggctggcacg tacagtgggg gcaacaagcg gaaactctcc     6240

acagccatcg cactcattgg ctgcccaccg ctggtgctgc tggatgagcc caccacaggg     6300

atggaccccc aggcacgccg catgctgtgg aacgtcatcg tgagcatcat cagagaaggg     6360

agggctgtgg tcctcacatc ccacagcatg gaagaatgtg aggcactgtg tacccggctg     6420

gccatcatgg taaagggcgc ctttcgatgt atgggcacca ttcagcatct caagtccaaa     6480

tttggagatg gctatatcgt cacaatgaag atcaaatccc cgaaggacga cctgcttcct     6540

gacctgaacc ctgtggagca gttcttccag gggaacttcc caggcagtgt gcagagggag     6600

aggcactaca acatgctcca gttccaggtc tcctcctcct ccctggcgag gatcttccag     6660

ctcctcctct cccacaagga cagcctgctc atcgaggagt actcagtcac acagaccaca     6720

ctggaccagg tgtttgtaaa ttttgctaaa cagcagactg aaagtcatga cctccctctg     6780

caccctcgag ctgctggagc cagtcgacaa gcccaggact ga                        6822


<210>  43
<211>  2918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example 5' end portion of a ABCA4 transgene

<400>  43
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc gctctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga attcgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct tcccacactc      780

ctagacagcc gttctcaagg tatcaatctg agatcttggg gaggaatatt atctgatatg      840

tcaccaagaa ttcaagagtt tatccatcgg ccgagtatgc aggacttgct gtgggtgacc      900

aggcccctca tgcagaatgg tggtccagag acctttacaa agctgatggg catcctgtct      960

gacctcctgt gtggctaccc cgagggaggt ggctctcggg tgctctcctt caactggtat     1020

gaagacaata actataaggc ctttctgggg attgactcca caaggaagga tcctatctat     1080

tcttatgaca gaagaacaac atccttttgt aatgcattga tccagagcct ggagtcaaat     1140

cctttaacca aaatcgcttg gagggcggca aagcctttgc tgatgggaaa aatcctgtac     1200

actcctgatt cacctgcagc acgaaggata ctgaagaatg ccaactcaac ttttgaagaa     1260

ctggaacacg ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca gatctggtac     1320

ttctttgaca acagcacaca gatgaacatg atcagagata ccctggggaa cccaacagta     1380

aaagactttt tgaataggca gcttggtgaa gaaggtatta ctgctgaagc catcctaaac     1440

ttcctctaca agggccctcg ggaaagccag gctgacgaca tggccaactt cgactggagg     1500

gacatattta acatcactga tcgcaccctc cgccttgtca atcaatacct ggagtgcttg     1560

gtcctggata agtttgaaag ctacaatgat gaaactcagc tcacccaacg tgccctctct     1620

ctactggagg aaaacatgtt ctgggccgga gtggtattcc ctgacatgta tccctggacc     1680

agctctctac caccccacgt gaagtataag atccgaatgg acatagacgt ggtggagaaa     1740

accaataaga ttaaagacag gtattgggat tctggtccca gagctgatcc cgtggaagat     1800

ttccggtaca tctggggcgg gtttgcctat ctgcaggaca tggttgaaca ggggatcaca     1860

aggagccagg tgcaggcgga ggctccagtt ggaatctacc tccagcagat gccctacccc     1920

tgcttcgtgg acgattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg     1980

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg     2040

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg     2100

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg     2160

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     2220

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     2280

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     2340

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     2400

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     2460

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     2520

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     2580

tttccaggag actatggaac cccacttcct tggtactttc ttctacaaga gtcgtattgg     2640

cttggcggtg aagggtgttc aaccagagaa gaaagagccc tggaaaagac cgagccccta     2700

acagaggaaa cggaggatcc agagcaccca gaaggaatac acgactcctt ctttgaacgt     2760

gagcatccag ggtgggttcc tggggtatgc gtgaagaatc tggtaaagat ttttgagccc     2820

tgtggccggc cagctgtgga ccgtctgaac atcaccttct acgagaacca gatcaccgca     2880

ttcctgggcc acaatggagc tgggaaaacc accacctt                             2918


<210>  44
<211>  3904
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example 3' end portion of a ABCA4 transgene

<400>  44
gtccatcctg acgggtctgt tgccaccaac ctctgggact gtgctcgttg ggggaaggga       60

cattgaaacc agcctggatg cagtccggca gagccttggc atgtgtccac agcacaacat      120

cctgttccac cacctcacgg tggctgagca catgctgttc tatgcccagc tgaaaggaaa      180

gtcccaggag gaggcccagc tggagatgga agccatgttg gaggacacag gcctccacca      240

caagcggaat gaagaggctc aggacctatc aggtggcatg cagagaaagc tgtcggttgc      300

cattgccttt gtgggagatg ccaaggtggt gattctggac gaacccacct ctggggtgga      360

cccttactcg agacgctcaa tctgggatct gctcctgaag tatcgctcag gcagaaccat      420

catcatgtcc actcaccaca tggacgaggc cgacctcctt ggggaccgca ttgccatcat      480

tgcccaggga aggctctact gctcaggcac cccactcttc ctgaagaact gctttggcac      540

aggcttgtac ttaaccttgg tgcgcaagat gaaaaacatc cagagccaaa ggaaaggcag      600

tgaggggacc tgcagctgct cgtctaaggg tttctccacc acgtgtccag cccacgtcga      660

tgacctaact ccagaacaag tcctggatgg ggatgtaaat gagctgatgg atgtagttct      720

ccaccatgtt ccagaggcaa agctggtgga gtgcattggt caagaactta tcttccttct      780

tccaaataag aacttcaagc acagagcata tgccagcctt ttcagagagc tggaggagac      840

gctggctgac cttggtctca gcagttttgg aatttctgac actcccctgg aagagatttt      900

tctgaaggtc acggaggatt ctgattcagg acctctgttt gcgggtggcg ctcagcagaa      960

aagagaaaac gtcaaccccc gacacccctg cttgggtccc agagagaagg ctggacagac     1020

accccaggac tccaatgtct gctccccagg ggcgccggct gctcacccag agggccagcc     1080

tcccccagag ccagagtgcc caggcccgca gctcaacacg gggacacagc tggtcctcca     1140

gcatgtgcag gcgctgctgg tcaagagatt ccaacacacc atccgcagcc acaaggactt     1200

cctggcgcag atcgtgctcc cggctacctt tgtgtttttg gctctgatgc tttctattgt     1260

tatccctcct tttggcgaat accccgcttt gacccttcac ccctggatat atgggcagca     1320

gtacaccttc ttcagcatgg atgaaccagg cagtgagcag ttcacggtac ttgcagacgt     1380

cctcctgaat aagccaggct ttggcaaccg ctgcctgaag gaagggtggc ttccggagta     1440

cccctgtggc aactcaacac cctggaagac tccttctgtg tccccaaaca tcacccagct     1500

gttccagaag cagaaatgga cacaggtcaa cccttcacca tcctgcaggt gcagcaccag     1560

ggagaagctc accatgctgc cagagtgccc cgagggtgcc gggggcctcc cgccccccca     1620

gagaacacag cgcagcacgg aaattctaca agacctgacg gacaggaaca tctccgactt     1680

cttggtaaaa acgtatcctg ctcttataag aagcagctta aagagcaaat tctgggtcaa     1740

tgaacagagg tatggaggaa tttccattgg aggaaagctc ccagtcgtcc ccatcacggg     1800

ggaagcactt gttgggtttt taagcgacct tggccggatc atgaatgtga gcgggggccc     1860

tatcactaga gaggcctcta aagaaatacc tgatttcctt aaacatctag aaactgaaga     1920

caacattaag gtgtggttta ataacaaagg ctggcatgcc ctggtcagct ttctcaatgt     1980

ggcccacaac gccatcttac gggccagcct gcctaaggac agaagccccg aggagtatgg     2040

aatcaccgtc attagccaac ccctgaacct gaccaaggag cagctctcag agattacagt     2100

gctgaccact tcagtggatg ctgtggttgc catctgcgtg attttctcca tgtccttcgt     2160

cccagccagc tttgtccttt atttgatcca ggagcgggtg aacaaatcca agcacctcca     2220

gtttatcagt ggagtgagcc ccaccaccta ctgggtaacc aacttcctct gggacatcat     2280

gaattattcc gtgagtgctg ggctggtggt gggcatcttc atcgggtttc agaagaaagc     2340

ctacacttct ccagaaaacc ttcctgccct tgtggcactg ctcctgctgt atggatgggc     2400

ggtcattccc atgatgtacc cagcatcctt cctgtttgat gtccccagca cagcctatgt     2460

ggctttatct tgtgctaatc tgttcatcgg catcaacagc agtgctatta ccttcatctt     2520

ggaattattt gagaataacc ggacgctgct caggttcaac gccgtgctga ggaagctgct     2580

cattgtcttc ccccacttct gcctgggccg gggcctcatt gaccttgcac tgagccaggc     2640

tgtgacagat gtctatgccc ggtttggtga ggagcactct gcaaatccgt tccactggga     2700

cctgattggg aagaacctgt ttgccatggt ggtggaaggg gtggtgtact tcctcctgac     2760

cctgctggtc cagcgccact tcttcctctc ccaatggatt gccgagccca ctaaggagcc     2820

cattgttgat gaagatgatg atgtggctga agaaagacaa agaattatta ctggtggaaa     2880

taaaactgac atcttaaggc tacatgaact aaccaagatt tatccaggca cctccagccc     2940

agcagtggac aggctgtgtg tcggagttcg ccctggagag tgctttggcc tcctgggagt     3000

gaatggtgcc ggcaaaacaa ccacattcaa gatgctcact ggggacacca cagtgacctc     3060

aggggatgcc accgtagcag gcaagagtat tttaaccaat atttctgaag tccatcaaaa     3120

tatgggctac tgtcctcagt ttgatgcaat cgatgagctg ctcacaggac gagaacatct     3180

ttacctttat gcccggcttc gaggtgtacc agcagaagaa atcgaaaagg ttgcaaactg     3240

gagtattaag agcctgggcc tgactgtcta cgccgactgc ctggctggca cgtacagtgg     3300

gggcaacaag cggaaactct ccacagccat cgcactcatt ggctgcccac cgctggtgct     3360

gctggatgag cccaccacag ggatggaccc ccaggcacgc cgcatgctgt ggaacgtcat     3420

cgtgagcatc atcagagaag ggagggctgt ggtcctcaca tcccacagca tggaagaatg     3480

tgaggcactg tgtacccggc tggccatcat ggtaaagggc gcctttcgat gtatgggcac     3540

cattcagcat ctcaagtcca aatttggaga tggctatatc gtcacaatga agatcaaatc     3600

cccgaaggac gacctgcttc ctgacctgaa ccctgtggag cagttcttcc aggggaactt     3660

cccaggcagt gtgcagaggg agaggcacta caacatgctc cagttccagg tctcctcctc     3720

ctccctggcg aggatcttcc agctcctcct ctcccacaag gacagcctgc tcatcgagga     3780

gtactcagtc acacagacca cactggacca ggtgtttgta aattttgcta aacagcagac     3840

tgaaagtcat gacctccctc tgcaccctcg agctgctgga gccagtcgac aagcccagga     3900

ctga                                                                  3904


<210>  45
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Asp Met Val Asp Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu 
1               5                   10                  15      


Pro Gly Gln Glu Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg 
            20                  25                  30          


Gly Arg Arg Glu Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu 
        35                  40                  45              


Pro Asp Glu Asp Glu Glu Asp Leu Ser Glu Tyr Lys Phe Ala Lys Phe 
    50                  55                  60                  


Ala Ala Thr Tyr Phe Gln Gly Thr Thr Thr His Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Pro Leu Lys Gln Pro Leu Leu Tyr His Asp Asp Glu Gly Asp Gln Leu 
                85                  90                  95      


Ala Ala Leu Ala Val Trp Ile Thr Ile Leu Arg Phe Met Gly Asp Leu 
            100                 105                 110         


Pro Glu Pro Lys Tyr His Thr Ala Met Ser Asp Gly Ser Glu Lys Ile 
        115                 120                 125             


Pro Val 
    130 


