                         SEQUENCE LISTING

<110>  CytoKi Pharma ApS
 
<120>  Therapeutic Derivatives of Interleukin-22

<130>  CTKI-003/001WO 338294-2039

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be inserted in SEQ ID NO. 1 (to create an 
       experimentally altered version of SEQ ID NO. 1)

<400>  2

Arg Val Gln Phe Gln 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be inserted in SEQ ID NO. 1 (to create an 
       experimentally altered version of SEQ ID NO. 1)

<400>  3

Cys Val Glu Ile Pro 
1               5   


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be inserted in SEQ ID NO. 1 (to create an 
       experimentally altered version of SEQ ID NO. 1)

<400>  4

Gly Ser Gly Ser Gly Ser Cys 
1               5           


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be inserted in SEQ ID NO. 1 (to create an 
       experimentally altered version of SEQ ID NO. 1)

<400>  5

Ile Glu Ala Leu Thr Pro His Ser 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be inserted in SEQ ID NO. 1 (to create an 
       experimentally altered version of SEQ ID NO. 1)

<400>  6

Tyr Gly Gln Arg Gln Trp Lys Asn 
1               5               


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be inserted in SEQ ID NO. 1 (to create an 
       experimentally altered version of SEQ ID NO. 1)

<400>  7

Val Phe Ile Ile Asn Asn Ser Leu Glu 
1               5                   


<210>  8
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be inserted in SEQ ID NO. 1 (to create an 
       experimentally altered version of SEQ ID NO. 1)

<400>  8

Arg Ala Ala Ser Ala Gly Ser Tyr Ser Glu Trp Ser Met Thr Pro Arg 
1               5                   10                  15      


Phe Thr Pro Trp Trp Glu Thr Lys Ile Asp Pro Pro Val Met Asn Ile 
            20                  25                  30          


Thr Gln Val Asn Gly Ser Leu Leu Val Ile Leu His 
        35                  40                  


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be added as an N-terminal peptide on SEQ ID NO. 1 
       (to create an experimentally altered version of SEQ ID NO. 1)

<400>  9

Ala Glu Pro Glu Glu 
1               5   


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be added as an N-terminal peptide on SEQ ID NO. 1 
       (to create an experimentally altered version of SEQ ID NO. 1)

<400>  10

Gly Pro Ala Glu Pro Glu Glu 
1               5           


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be added as an N-terminal peptide on SEQ ID NO. 1 
       (to create an experimentally altered version of SEQ ID NO. 1)

<400>  11

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10          


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be added as an N-terminal peptide on SEQ ID NO. 1 
       (to create an experimentally altered version of SEQ ID NO. 1)

<400>  12

Gly Gly Ser Ser Gly Ser Gly Ser Glu Val Leu Phe Gln 
1               5                   10              


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be added as an N-terminal peptide on SEQ ID NO. 1 
       (to create an experimentally altered version of SEQ ID NO. 1)

<400>  13

Gly Pro Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be added as an N-terminal peptide on SEQ ID NO. 1 
       (to create an experimentally altered version of SEQ ID NO. 1)

<400>  14

Gly Gly Ser Ser Gly Ser Gly Ser Glu Val Leu Phe Gln Gly 
1               5                   10                  


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be added as an N-terminal peptide on SEQ ID NO. 1 
       (to create an experimentally altered version of SEQ ID NO. 1)

<400>  15

Gly Gly Ser Ser Gly Ser Gly Ser Glu Val Leu Phe Gln Gly Pro Gly 
1               5                   10                  15      


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be added as an N-terminal peptide on SEQ ID NO. 1 
       (to create an experimentally altered version of SEQ ID NO. 1)

<400>  16

Gly Gly Ser Ser Gly Ser Gly Ser Glu Val Leu Phe Gln Gly Pro Ala 
1               5                   10                  15      


Glu Pro Glu Glu 
            20  


<210>  17
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be added as an N-terminal peptide on SEQ ID NO. 1 
       (to create an experimentally altered version of SEQ ID NO. 1)

<400>  17

Gly Gly Ser Ser Gly Ser Gly Ser Glu Val Leu Phe Gln Gly Pro Gly 
1               5                   10                  15      


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25          


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  n-mer that can be added as a C-terminal peptide on SEQ ID NO. 1 
       (to create an experimentally altered version of SEQ ID NO. 1)

<400>  18

Gly Ser Gly Ser Gly Ser Cys 
1               5           


<210>  19
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  19

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Gln Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Gln 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Cys His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  20
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  20

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Gln Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Gln 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Cys Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tag

<400>  21

His His His His His His Gly Gly Ser Ser Gly Ser Gly Ser Glu Val 
1               5                   10                  15      


Leu Phe Gln 
            


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for native cut site in protease-cleavable TEV 
       linker

<400>  22

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  23
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  23

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Cys His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  24
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  24

Gly Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  25
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  25

Gly Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asp Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asp Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asp 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  26
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  26

Gly Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Gln Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Gln 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  27
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  27

Gly Pro Gly Cys Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn 
1               5                   10                  15      


Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu 
            20                  25                  30          


Ala Ser Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys 
        35                  40                  45              


Leu Phe His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln 
    50                  55                  60                  


Val Leu Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg 
65                  70                  75                  80  


Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser 
                85                  90                  95      


Asn Arg Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln 
            100                 105                 110         


Arg Asn Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser 
        115                 120                 125             


Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu 
    130                 135                 140                 


Arg Asn Ala Cys Ile 
145                 


<210>  28
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  28

Gly Pro Gly Cys Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn 
1               5                   10                  15      


Phe Gln Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu 
            20                  25                  30          


Ala Ser Leu Ala Asp Gln Asn Thr Asp Val Arg Leu Ile Gly Glu Lys 
        35                  40                  45              


Leu Phe His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln 
    50                  55                  60                  


Val Leu Gln Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg 
65                  70                  75                  80  


Phe Gln Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser 
                85                  90                  95      


Asn Arg Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln 
            100                 105                 110         


Arg Asn Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser 
        115                 120                 125             


Gly Glu Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu 
    130                 135                 140                 


Arg Asn Ala Cys Ile 
145                 


<210>  29
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  29

Gly Pro Gly Ser Gly Ser Gly Ser Cys Gly Ser Gly Ser Gly Ser Ala 
1               5                   10                  15      


Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln Pro 
            20                  25                  30          


Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu Ala 
        35                  40                  45              


Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His Gly 
    50                  55                  60                  


Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn Phe 
65                  70                  75                  80  


Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro Tyr 
                85                  90                  95      


Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu Ser 
            100                 105                 110         


Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val Gln 
        115                 120                 125             


Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile Lys 
    130                 135                 140                 


Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala Cys 
145                 150                 155                 160 


Ile 
    


<210>  30
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  30

Cys Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Gln Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Gln 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


<210>  31
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  31

Gly Ala Pro Ile Ser Ser Cys Cys Arg Leu Asp Lys Ser Asn Phe Gln 
1               5                   10                  15      


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
            20                  25                  30          


Leu Ala Asp Gln Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
        35                  40                  45              


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
    50                  55                  60                  


Gln Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
65                  70                  75                  80  


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
                85                  90                  95      


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
            100                 105                 110         


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
        115                 120                 125             


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
    130                 135                 140                 


Ala Cys Ile 
145         


<210>  32
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  32

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Cys Asp Gln Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Gln 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     



<210>  33
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  33

Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Cys Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     



<210>  34
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Experimentally altered version of SEQ ID NO. 1

<400>  34

Cys Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln Gln 
1               5                   10                  15      


Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser Leu 
            20                  25                  30          


Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe His 
        35                  40                  45              


Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu Asn 
    50                  55                  60                  


Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln Pro 
65                  70                  75                  80  


Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg Leu 
                85                  90                  95      


Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn Val 
            100                 105                 110         


Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu Ile 
        115                 120                 125             


Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn Ala 
    130                 135                 140                 


Cys Ile 
145     


