                         SEQUENCE LISTING

<110>  ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
 
<120>  KRAB-containing zinc finger protein and Cancer

<130>  PAT7576PC00

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  2431
<212>  DNA
<213>  Homo sapiens

<400>  1
gtagcggaca ttttgtttct gtcaggctgt ccctggccgg ggttctgtaa cgcttgtgtg       60

ggccgcaggt ggaggtgttg ggaaagcgcg gaggagatgt tgtccccagt gtcccgagac      120

gcgtctgatg ctctgcaggg acggaagtgc ctgcgtcccc gatcgagacg cctgccgctc      180

ccggcagctg tccgcgccca cggtcctatg gcggagctaa cggactccgc gcggggctgt      240

gtggtctttg aggatgtgtt tgtatacttc tctcgggaag aatgggagct tcttgatgat      300

gctcagagac ttttgtacca tgatgtgatg ctggagaact ttgcactttt agcctcactg      360

ggaattgcat tttccagatc acgtgcagtc atgaaactag agcgaggaga agagccctgg      420

gtgtatgacc aggtggatat gacttcagcc acagaaagag aggcccagag gggacttaga      480

cctggttgtt ggcatggagt ggaggatgaa gaggtatctt ctgagcagag catttttgta      540

gcaggagtgt cagaggtcag gactctcatg gcagagctgg agtctcaccc atgtgacata      600

tgtggcccaa tattgaaaga taccttacac ctggctaaat accatggggg aaaagccagg      660

cagaaaccat acttgtgtgg ggcatgtgga aagcaattct ggttcagtac agactttgac      720

cagcaccaga accagcccaa tggagggaaa cttttcccaa ggaaggaggg cagagactct      780

gtgaaaagct gcagagtcca tgtgccagag aagaccctca catgtgggaa aggtaggaga      840

gacttttcag ccacatctgg ccttcttcag catcaggcct ctctcagcag catgaagccc      900

cacaagagca ctaagcttgt gagtggcttt ctcatgggac agaggtatca caggtgtggt      960

gaatgtggga aagccttcac ccgcaaagac acacttgctc ggcatcagag aatccacact     1020

ggagaaaggc cttatgagtg taacgaatgt gggaaattct tcagccaaag ctatgacctc     1080

tttaaacacc agacagttca cactggagaa aggccatacg agtgcagcga atgtgggaaa     1140

ttctttagac aaatctccgg cctgattgag cacaggcgag ttcacacggg tgaaagactc     1200

tatcagtgtg gcaaatgtgg gaaatttttt agcagtaagt ctaatctcat tcgacaccag     1260

gaagttcaca caggagccag gccttatgta tgcagcgaat gtgggaaaga gttcagtcgg     1320

aaacacacac ttgttctgca ccaacgaact cacactggag aaaggcctta tgagtgcagt     1380

gaatgtggga aggcctttag ccaaagctcc caccttaatg tacactggag aattcacagc     1440

agtgattatg agtgtagcag atgtggtaaa gctttcagct gcatctccaa actcattcag     1500

caccagaaag ttcactctgg agaaaagcct tatgagtgca gcaagtgcgg gaaagccttc     1560

actcaaagac ccaacctcat caggcactgg aaagtccaca ctggggaaag gccttatgtg     1620

tgtagtgagt gcgggagaga attcatccgg aaacagacac ttgttctgca ccagagggtt     1680

catgctggag aaaagcttta agagtgtagc aaatgtgggg gaaagtctta ggccaatgcc     1740

cctgacttac tatatggtgg ggaactagca gtagttaatg agtgcagcag atgcaggaaa     1800

gccttcccct ggaggctgaa ccttacccgc cattgggaat ttcacaccgg acacaggcct     1860

tagcagtcta agcaatgtgc tgtctctgtt cagcccaaca gctcacccta gagtggaact     1920

ctgggagcag ccattgggag ggaaccatca gtaagaagtg aaacttcata gatatggaca     1980

ttcccactgg ggagattccc tgtgagtgtc aagtatgtga gatgctttca gcagctgtgt     2040

tgcacttttt aaatggctat tggcctttgc tggggcagga gccatctgct cctaccatct     2100

ggcagaatca tactgcgttt accatttacc ccagcatgct tgtgacgggc agacctctct     2160

tctctcccca gtccctaaaa ggtgttgtga gtggtctcac agcccactag gggtcttaat     2220

ttcctctctt ttgatgtaaa tggcatggaa ataatcagct ttgttcaaga ggacacagaa     2280

ggattctgca aatagcctgc agagacttac ctgtgttgat tgatttcata tgatgctcgt     2340

tatggatata tccaatatcc aagtcaccca gctctggaac tgcctgcttc acattgctca     2400

tgataataaa ggcctgttct ttaagccacc a                                    2431


<210>  2
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Ser Pro Val Ser Arg Asp Ala Ser Asp Ala Leu Gln Gly Arg 
1               5                   10                  15      


Lys Cys Leu Arg Pro Arg Ser Arg Arg Leu Pro Leu Pro Ala Ala Val 
            20                  25                  30          


Arg Ala His Gly Pro Met Ala Glu Leu Thr Asp Ser Ala Arg Gly Cys 
        35                  40                  45              


Val Val Phe Glu Asp Val Phe Val Tyr Phe Ser Arg Glu Glu Trp Glu 
    50                  55                  60                  


Leu Leu Asp Asp Ala Gln Arg Leu Leu Tyr His Asp Val Met Leu Glu 
65                  70                  75                  80  


Asn Phe Ala Leu Leu Ala Ser Leu Gly Ile Ala Phe Ser Arg Ser Arg 
                85                  90                  95      


Ala Val Met Lys Leu Glu Arg Gly Glu Glu Pro Trp Val Tyr Asp Gln 
            100                 105                 110         


Val Asp Met Thr Ser Ala Thr Glu Arg Glu Ala Gln Arg Gly Leu Arg 
        115                 120                 125             


Pro Gly Cys Trp His Gly Val Glu Asp Glu Glu Val Ser Ser Glu Gln 
    130                 135                 140                 


Ser Ile Phe Val Ala Gly Val Ser Glu Val Arg Thr Leu Met Ala Glu 
145                 150                 155                 160 


Leu Glu Ser His Pro Cys Asp Ile Cys Gly Pro Ile Leu Lys Asp Thr 
                165                 170                 175     


Leu His Leu Ala Lys Tyr His Gly Gly Lys Ala Arg Gln Lys Pro Tyr 
            180                 185                 190         


Leu Cys Gly Ala Cys Gly Lys Gln Phe Trp Phe Ser Thr Asp Phe Asp 
        195                 200                 205             


Gln His Gln Asn Gln Pro Asn Gly Gly Lys Leu Phe Pro Arg Lys Glu 
    210                 215                 220                 


Gly Arg Asp Ser Val Lys Ser Cys Arg Val His Val Pro Glu Lys Thr 
225                 230                 235                 240 


Leu Thr Cys Gly Lys Gly Arg Arg Asp Phe Ser Ala Thr Ser Gly Leu 
                245                 250                 255     


Leu Gln His Gln Ala Ser Leu Ser Ser Met Lys Pro His Lys Ser Thr 
            260                 265                 270         


Lys Leu Val Ser Gly Phe Leu Met Gly Gln Arg Tyr His Arg Cys Gly 
        275                 280                 285             


Glu Cys Gly Lys Ala Phe Thr Arg Lys Asp Thr Leu Ala Arg His Gln 
    290                 295                 300                 


Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Asn Glu Cys Gly Lys 
305                 310                 315                 320 


Phe Phe Ser Gln Ser Tyr Asp Leu Phe Lys His Gln Thr Val His Thr 
                325                 330                 335     


Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Phe Phe Arg Gln 
            340                 345                 350         


Ile Ser Gly Leu Ile Glu His Arg Arg Val His Thr Gly Glu Arg Leu 
        355                 360                 365             


Tyr Gln Cys Gly Lys Cys Gly Lys Phe Phe Ser Ser Lys Ser Asn Leu 
    370                 375                 380                 


Ile Arg His Gln Glu Val His Thr Gly Ala Arg Pro Tyr Val Cys Ser 
385                 390                 395                 400 


Glu Cys Gly Lys Glu Phe Ser Arg Lys His Thr Leu Val Leu His Gln 
                405                 410                 415     


Arg Thr His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys 
            420                 425                 430         


Ala Phe Ser Gln Ser Ser His Leu Asn Val His Trp Arg Ile His Ser 
        435                 440                 445             


Ser Asp Tyr Glu Cys Ser Arg Cys Gly Lys Ala Phe Ser Cys Ile Ser 
    450                 455                 460                 


Lys Leu Ile Gln His Gln Lys Val His Ser Gly Glu Lys Pro Tyr Glu 
465                 470                 475                 480 


Cys Ser Lys Cys Gly Lys Ala Phe Thr Gln Arg Pro Asn Leu Ile Arg 
                485                 490                 495     


His Trp Lys Val His Thr Gly Glu Arg Pro Tyr Val Cys Ser Glu Cys 
            500                 505                 510         


Gly Arg Glu Phe Ile Arg Lys Gln Thr Leu Val Leu His Gln Arg Val 
        515                 520                 525             


His Ala Gly Glu Lys Leu 
    530                 


<210>  3
<211>  5262
<212>  DNA
<213>  Homo sapiens

<400>  3
agtggccatt ttgattggtg ttgggtgtat tttccagtga gagaccgcgg agtgttgggt       60

cgtgtagaag tgactgaacc cagaaggtgg agacgagacg ttgtcccgac tgcacagagg      120

ctgctctgca gctccttaaa ggcgctaggc gtgacccgca ccaaggccgg gatcgggacc      180

accgtgcccg ggtacctgca ctgctcgccc cctcctttcg accccgcttt ccccacccag      240

tcggatggcg gcggccgcgc tgaggccccc ggctcagggc actgtgacct ttgaagatgt      300

ggctgtgaac ttttcccagg aggaatggag tctccttagt gaggctcaga gatgccttta      360

tcatgacgtg atgctggaga acctgacact tatatcttct ctaggttgtt ggtatggagc      420

aaaagacgag acaccttcta agcagaccct ttctatacaa caggagtccc cactcaggac      480

acattggaca ggtgtatgta ccaagaaggt ccacctctgg ggaatgtgtg gccctctcct      540

gggagatatc ttacaccagg gaacacaaca caatcagaaa ttgaatgggt ttggggcata      600

tgaaaaaaaa ttggatgacg atgcaaacca tcatcaagac cagaagcagc acattggaga      660

gaaatcgtac agaagcaatg ccaagggaac atcttttgta aagaactgta aattccatat      720

gtcacatgag ccatttatct ttcatgaggt tgggaaagac tttttgtcca gcttgagatt      780

actccaacaa gaggacattc acacttcagg gaagtcaaac tttgaaacta agcatgggat      840

accccttcag ggtggaaaaa ctcattacat ctgtggagag tccacaatac cgtttagcaa      900

caaacactca cttgtccttc accagagact tctccctaga gaaggacctt atgtatgcag      960

tgattctggg aaattcacta gcaaaagtaa tagttttaat aatcatcagg gagttcgcac     1020

tggaaaaaga ccttatcagt gtggacaatg tgatgaatca ttttggtata aggcccacct     1080

cactgaacac cagagagttc acactggaga aagaccttat gagtgtggag aatgtgataa     1140

atcttttagt cataagcaca gtcttgttga ccatcagcga gttcacactg gagaaagacc     1200

ttatgaatgt gacgaatgtg ggaaatcttt tagccataag cgcagccttg ttcaccacca     1260

gcgagttcac actggagaaa gaccttatca gtgtggagaa tgtgggaaat cgtttaatca     1320

caagtgcaac ctcattcagc atcagcgagt tcacactgga gaaagacctt ttgagtgtac     1380

ggcatgtggg aagttattta ggagcaactc ccacctaaag gaacaccaga gagttcacac     1440

tggagaaaga ccctatgagt gtaaagaatg taggaaatca tttaggtaca agtcacacct     1500

cactgaacac cagagagttc acactggaga aaggccatat gagtgtagag aatgtgggaa     1560

atgttttcat caaaagggca gtctcattca acatcagcag atccactctg gagaaaggcc     1620

acatgagtgt ggagaatgtg ggaaatgttt tcatcaaaag ggcagtctca ttcgacatca     1680

gcagattcac tctggagaaa ggccacatga gtgtggagaa tgtggaaagt gttttcgtca     1740

aaagggaaac ctcattaaac atcaacgagt tcacacggga gaaagacatc atgaatgttg     1800

aaaatttggc agatctgttg gtaaaaagag caccctcatt caacattcgt gagatcacac     1860

tggaaagcac ttatgagtat ggagaatgtg caaaatcatc tagccaaaag gttggcctca     1920

ttcaacaata gcaagatcac actggggaaa ggctttctga gtgtagagaa tgtatgaaat     1980

cctgtacata gaagttttgc ctcaccaaat accagaaggg tcacactgga gaaagaccct     2040

atagttatgg ggaatttggg aaattaccta acaagaagtc ccacctcact gaacactact     2100

gagttcacag ttgagaaagg ccatatgact gtaaggaatt tgtaaaatta tttagccaga     2160

agagctgcat tactattcat cagataattt acaatggaga aaggccacat aataatttct     2220

cacataataa atgtgagaaa tcatttccgt acagctctgc gctccatgtt cgtaagagtt     2280

cacactggac aaagccttat gagagcagcg agtagaaaat cctttgtggg aaaactctgg     2340

tttcattaaa cacaggagag ttcatgctag agaaaggcct caacagtgta gcaaatatgg     2400

aaagacattc actagaagct ctgccctgca agttcacact agagaaagcc cttctcagtg     2460

aagtaaattt ggaaaattga ttagtcaaac ctctatgctc cttcaaaatc agagttcaca     2520

ctggatcaag gctttatggt gtgacaaata tggcacattc tttatctaaa tgtctaacat     2580

attatgcaca gacaagctcc tgctgtggaa gtgccttttg agtgcagagc atttgcgagg     2640

gcttcactct tctttcactg gataccagaa tgttgacagg agaaaaataa catagatgtg     2700

tgggaatatt acttcttgtc cagtgtaact gtgggagaga gcccttatga ggacaccatc     2760

aacctatatt gaatgtcata tgtccagtag ctgcataaat tccaggtata tgggagctgt     2820

attgcatttc ttatcctgcg tatgtccttg ccagatttat ttcattctta ggtctctggc     2880

aaaagccatt tcatctctac cacttggcag gtacctacag tgcatcactc atgcactcca     2940

tcatattcca gaaaaaaagt tcaagttgtc tcccattcag cagtggtatt tttgagtagc     3000

ctctgcactc gttcctttct catttctcta tgaagagtta ggccatggac ctgactcagt     3060

tctggcctag agcagaagtg tccaatcttt tggctttcct ggtccacatt ggaagaagaa     3120

ttgtcttgtg ccgcatatga aatacattaa cactaatgat agctgatgaa cttttttaaa     3180

aaatcacaca aaaaccctca taatgtttta agaaagttta caaatttgtg ttgggctgca     3240

ttcaaagctg tcctgagata catgcggccc acaagctgcg ggttggacca gcttggccta     3300

gagaattttt ctgattactt gacaagatgg gctgtctttc ctaggaatct catgattgtc     3360

atgattctta aaatggaatt ttccagcctc ttaactcacc aacccaagta caagctgcct     3420

ctcattgttc tggtttctgc tatgatgaag tccttattta agcttccttc aatcttggga     3480

attgtattga ctgtattgtg tgaattgtat actcactgca ttgtgtggct tagatacaac     3540

atggttctgg taccatgaag gattctggta ccatgaaagt ttgttggggt tactaaactg     3600

tgtgactctt agggaacagt atgaaggcag aatatagctc tgcatttgtg gcctagtttg     3660

gatggctgcc taaggcctcc aaataaagac ttcagggctt tgtgatcttt atttttagat     3720

gaaatagtgc aataatatgt gttttcataa atcaacctga gtaggggaca gttttagtga     3780

cacactttgg tgcttctgag aacagcacaa aattattctc ttgtttataa tggatattgc     3840

attctgctca gtactggtga gggaaatctg ttctcaagtc ctacagtgca ttcatgtgtc     3900

ctgaagtcca gaattctgta ggatagtgtc ctacgttata agcctggaga aagaaatcat     3960

aattctttaa tttttatttt tttagggaaa tgatgtcact ctgaaactca ggctggaata     4020

cactggcatg gtcatacctc actgcggcct caaactcctg ggctcaagtg atcctcctgc     4080

ctcagcctcc cgagtacctg agattagccc aggtaattta agaatttttt atagagatag     4140

ggttttgcta ttttaccctg actgatgttc aactcctggc ctcaagtaat cctctagcat     4200

acgcccttga aagcactagg attacaggtg tgagccacca tgcccagccc aaaaataatt     4260

tttgtagaat tagcatttct aggtagtgaa gcagactgca acagaatagt tgggatatac     4320

tttttttaaa aaggcatcca caatgattca gtcactatgt ctgtgatgga caagcaggta     4380

cagaaatttt caggacctcc ataattatga atctagtgta gcttaggtca ttgtcagact     4440

aaatctaaag gttttgtgga tttctgtagc ctatctgggc tgcataccaa aaagccatcc     4500

ctgaattagt aggaggaaga ggatagggag aaaggaaatc tcttagtcca gtgatgtggc     4560

ctttgcaacc agccagcatt ccaatttaat caggtggaaa tgatcttcct ggctcataag     4620

tatttggtat cacacaggct aattgccccc cttagggcgt gatgagagtt aggagagtca     4680

atgtaaaatc acataaccta tttgtcaaaa ataatgttaa atccagatag ttctttcaaa     4740

ttaaattttt aaagctgtaa taagactggg catggtgact catgcctgtt atcccaacac     4800

tttgggagtc cagggtggga gtattgcttg aggtaagaag tttgagacta gcctgggtcc     4860

catagtaaga ccctgtctct taaaaaataa atactatctt tctctctggc ctctccatgc     4920

tccagacaat cactgaatta caatatttgc ttaacagtag attaatgtca attttctgga     4980

attttatatg actgatataa catgtttcct cttttcatac ctgagtactc tcctgagccc     5040

tatttattta gatgttcttc ttttttcttt attattattt ttatttcaca tagcagggat     5100

gcatattttg acattcatca atcatgatat atgagtagtt cattcttttt atcttagaat     5160

atgacatgct atggaaatca ctgtatacga attcatctgc ttatggatat gttattgctt     5220

cttatttttg tctgttagga ataaaactgc ttgttaagca ca                        5262


<210>  4
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Ala Ala Leu Arg Pro Pro Ala Gln Gly Thr Val Thr Phe 
1               5                   10                  15      


Glu Asp Val Ala Val Asn Phe Ser Gln Glu Glu Trp Ser Leu Leu Ser 
            20                  25                  30          


Glu Ala Gln Arg Cys Leu Tyr His Asp Val Met Leu Glu Asn Leu Thr 
        35                  40                  45              


Leu Ile Ser Ser Leu Gly Cys Trp Tyr Gly Ala Lys Asp Glu Thr Pro 
    50                  55                  60                  


Ser Lys Gln Thr Leu Ser Ile Gln Gln Glu Ser Pro Leu Arg Thr His 
65                  70                  75                  80  


Trp Thr Gly Val Cys Thr Lys Lys Val His Leu Trp Gly Met Cys Gly 
                85                  90                  95      


Pro Leu Leu Gly Asp Ile Leu His Gln Gly Thr Gln His Asn Gln Lys 
            100                 105                 110         


Leu Asn Gly Phe Gly Ala Tyr Glu Lys Lys Leu Asp Asp Asp Ala Asn 
        115                 120                 125             


His His Gln Asp Gln Lys Gln His Ile Gly Glu Lys Ser Tyr Arg Ser 
    130                 135                 140                 


Asn Ala Lys Gly Thr Ser Phe Val Lys Asn Cys Lys Phe His Met Ser 
145                 150                 155                 160 


His Glu Pro Phe Ile Phe His Glu Val Gly Lys Asp Phe Leu Ser Ser 
                165                 170                 175     


Leu Arg Leu Leu Gln Gln Glu Asp Ile His Thr Ser Gly Lys Ser Asn 
            180                 185                 190         


Phe Glu Thr Lys His Gly Ile Pro Leu Gln Gly Gly Lys Thr His Tyr 
        195                 200                 205             


Ile Cys Gly Glu Ser Thr Ile Pro Phe Ser Asn Lys His Ser Leu Val 
    210                 215                 220                 


Leu His Gln Arg Leu Leu Pro Arg Glu Gly Pro Tyr Val Cys Ser Asp 
225                 230                 235                 240 


Ser Gly Lys Phe Thr Ser Lys Ser Asn Ser Phe Asn Asn His Gln Gly 
                245                 250                 255     


Val Arg Thr Gly Lys Arg Pro Tyr Gln Cys Gly Gln Cys Asp Glu Ser 
            260                 265                 270         


Phe Trp Tyr Lys Ala His Leu Thr Glu His Gln Arg Val His Thr Gly 
        275                 280                 285             


Glu Arg Pro Tyr Glu Cys Gly Glu Cys Asp Lys Ser Phe Ser His Lys 
    290                 295                 300                 


His Ser Leu Val Asp His Gln Arg Val His Thr Gly Glu Arg Pro Tyr 
305                 310                 315                 320 


Glu Cys Asp Glu Cys Gly Lys Ser Phe Ser His Lys Arg Ser Leu Val 
                325                 330                 335     


His His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Gln Cys Gly Glu 
            340                 345                 350         


Cys Gly Lys Ser Phe Asn His Lys Cys Asn Leu Ile Gln His Gln Arg 
        355                 360                 365             


Val His Thr Gly Glu Arg Pro Phe Glu Cys Thr Ala Cys Gly Lys Leu 
    370                 375                 380                 


Phe Arg Ser Asn Ser His Leu Lys Glu His Gln Arg Val His Thr Gly 
385                 390                 395                 400 


Glu Arg Pro Tyr Glu Cys Lys Glu Cys Arg Lys Ser Phe Arg Tyr Lys 
                405                 410                 415     


Ser His Leu Thr Glu His Gln Arg Val His Thr Gly Glu Arg Pro Tyr 
            420                 425                 430         


Glu Cys Arg Glu Cys Gly Lys Cys Phe His Gln Lys Gly Ser Leu Ile 
        435                 440                 445             


Gln His Gln Gln Ile His Ser Gly Glu Arg Pro His Glu Cys Gly Glu 
    450                 455                 460                 


Cys Gly Lys Cys Phe His Gln Lys Gly Ser Leu Ile Arg His Gln Gln 
465                 470                 475                 480 


Ile His Ser Gly Glu Arg Pro His Glu Cys Gly Glu Cys Gly Lys Cys 
                485                 490                 495     


Phe Arg Gln Lys Gly Asn Leu Ile Lys His Gln Arg Val His Thr Gly 
            500                 505                 510         


Glu Arg His His Glu Cys 
        515             


<210>  5
<211>  2196
<212>  DNA
<213>  Homo sapiens

<400>  5
gcctgtcagg tccatccggc gatgctgggt ctggacgagc tcgggaggag tggttgtggc       60

cattgcacac aggcggatct gaggttcggc gacgccgctg gtcgcgaccc gggacaggac      120

aacgacagga acaccgccga gcccgcgttc cccccccgcc cagagtcatg gcggcagcag      180

ccgctctgag ggcgcctgct cagagcagtg tgacctttga agatgtggct gtaaactttt      240

ccctggagga atggagtctt cttaatgagg ctcagagatg cctgtaccgt gacgtgatgc      300

tggagacctt gacacttata tcctccctgg gttgttggca tggaggggaa gatgaggcag      360

caccttctaa gcagagcacg tgtatacata tatacaaaga ccagggaggt catagtggag      420

aaaggcctta tgagtgtggg gaatatagga aattatttaa gaacaagtcc tgcctcactg      480

aacccagaag agatcacaaa cacaggaatg ttcgcactgg agaaaggcct tatgagtgca      540

gcaaatatgg gaaattattt caccaaaagc ctacactcca tattcatgag agatttcata      600

ctgggcaaaa gacctatgag tgcagtgagt gtggaaaatc atttcaccaa agctcttcac      660

tcttgcagcg tcagacactt cacactagag aaaggcctta tgagtgtatt gaatgtggga      720

aagcctttgc tgaaaagtcc agtctcatta accacaggaa agttcactct ggagcaaagc      780

gttatgaatg caatgaatgt gggaagtcct ttgcttatac atctagtctc attaaacaca      840

ggaggattca cactggagag aggccttatg agtgcagtga atgtgggaga tcctttgctg      900

aaaactccag tcttattaaa cacttgagag ttcacacagg agaaaggcct tatgaatgcg      960

ttgagtgtgg aaaatcattt cgccgaagct cttcactctt gcagcatcag agagttcaca     1020

ctagagaaag gccttatgaa tgtagtgaat gtgggaaatc ctttagctta aggtccaacc     1080

tcattcacca tcagcgagtt catactggag aaaggcatga gtgcgggcag tgtgggaaat     1140

cctttagccg aaaatctagc cttattatac atctgagagt tcacactgga gaaaggcctt     1200

atgagtgcag tgactgtggg aaatcctttg ctgaaaactc cagccttatt aaacacttga     1260

gagttcacac tggagaaagg ccatatgaat gcattgattg tggaaaatca tttcgccaca     1320

gttcttcgtt ccgtcgccat cagagagttc atactggaat gaggccttat aagtgaagca     1380

aattttggaa attctcttgc ccaggctttt tgctccttca aggccagaga gttcacacca     1440

gatcaaggtg ttatgagtgt gacaaatggg gaatattctt tagctagaat gctagcttct     1500

ttacataaaa gagtgctccc actgaagaag tgccttttga gtgcaatgaa tgtgagaaag     1560

ccttcagccc tctctcattg gttaccacaa tatttacatg aggaaaatac cacagatgtg     1620

gaggtaatat tattttttct tcaatataac actggaggaa accccttatg aggatgccat     1680

ctgcctaaat tgaatgtcat acatcaaata gctgcataca ttccaggtat gtgggaactg     1740

catagtattt ttcgacctgc ccaggtctct tgctagactt ctgtgactta cagttctctt     1800

ctaaaaagca tttcaccttt accacttggc aggtgcccac agtacatcat tcgcctaact     1860

catcatgatc cagaagtaac tttgattttg tttcattcaa cagagggatt ttttagtatc     1920

ctcagcactc attctattct catttctttc tctccaatga gttaggccat gaacctgact     1980

catttttggc acagaggact cttctgataa cttgaaaaaa tggactacct ttttcaggga     2040

tcttttggat ctcacagagt tcttaagatg gaattttcca gcctgccagt catgaatctc     2100

agacagcctg ccacctattg ccctgatttg tgttataata aaggccttgt tgcttaagac     2160

accttcagtc tttgcaggag ggcatggaag ctccaa                               2196


<210>  6
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Ala Ala Ala Leu Arg Ala Pro Ala Gln Ser Ser Val Thr 
1               5                   10                  15      


Phe Glu Asp Val Ala Val Asn Phe Ser Leu Glu Glu Trp Ser Leu Leu 
            20                  25                  30          


Asn Glu Ala Gln Arg Cys Leu Tyr Arg Asp Val Met Leu Glu Thr Leu 
        35                  40                  45              


Thr Leu Ile Ser Ser Leu Gly Cys Trp His Gly Gly Glu Asp Glu Ala 
    50                  55                  60                  


Ala Pro Ser Lys Gln Ser Thr Cys Ile His Ile Tyr Lys Asp Gln Gly 
65                  70                  75                  80  


Gly His Ser Gly Glu Arg Pro Tyr Glu Cys Gly Glu Tyr Arg Lys Leu 
                85                  90                  95      


Phe Lys Asn Lys Ser Cys Leu Thr Glu Pro Arg Arg Asp His Lys His 
            100                 105                 110         


Arg Asn Val Arg Thr Gly Glu Arg Pro Tyr Glu Cys Ser Lys Tyr Gly 
        115                 120                 125             


Lys Leu Phe His Gln Lys Pro Thr Leu His Ile His Glu Arg Phe His 
    130                 135                 140                 


Thr Gly Gln Lys Thr Tyr Glu Cys Ser Glu Cys Gly Lys Ser Phe His 
145                 150                 155                 160 


Gln Ser Ser Ser Leu Leu Gln Arg Gln Thr Leu His Thr Arg Glu Arg 
                165                 170                 175     


Pro Tyr Glu Cys Ile Glu Cys Gly Lys Ala Phe Ala Glu Lys Ser Ser 
            180                 185                 190         


Leu Ile Asn His Arg Lys Val His Ser Gly Ala Lys Arg Tyr Glu Cys 
        195                 200                 205             


Asn Glu Cys Gly Lys Ser Phe Ala Tyr Thr Ser Ser Leu Ile Lys His 
    210                 215                 220                 


Arg Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly 
225                 230                 235                 240 


Arg Ser Phe Ala Glu Asn Ser Ser Leu Ile Lys His Leu Arg Val His 
                245                 250                 255     


Thr Gly Glu Arg Pro Tyr Glu Cys Val Glu Cys Gly Lys Ser Phe Arg 
            260                 265                 270         


Arg Ser Ser Ser Leu Leu Gln His Gln Arg Val His Thr Arg Glu Arg 
        275                 280                 285             


Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ser Phe Ser Leu Arg Ser Asn 
    290                 295                 300                 


Leu Ile His His Gln Arg Val His Thr Gly Glu Arg His Glu Cys Gly 
305                 310                 315                 320 


Gln Cys Gly Lys Ser Phe Ser Arg Lys Ser Ser Leu Ile Ile His Leu 
                325                 330                 335     


Arg Val His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Asp Cys Gly Lys 
            340                 345                 350         


Ser Phe Ala Glu Asn Ser Ser Leu Ile Lys His Leu Arg Val His Thr 
        355                 360                 365             


Gly Glu Arg Pro Tyr Glu Cys Ile Asp Cys Gly Lys Ser Phe Arg His 
    370                 375                 380                 


Ser Ser Ser Phe Arg Arg His Gln Arg Val His Thr Gly Met Arg Pro 
385                 390                 395                 400 


Tyr Lys 
        


<210>  7
<211>  2352
<212>  DNA
<213>  Homo sapiens

<400>  7
agtagcgacc atttccattg gcgttaggga gtccttggag cgctgtgttg ggaccgtggt       60

ggtgactgga tccaggaggt cgagagtcgt tcttctcttt gcacagacgt gactctgcag      120

ctctttaacg gcgcccgctg ctctcaaccc agcttacccc acgtggtccc atggcggcgg      180

ccgcgctaag gttccccgtt cagggcacag tgacttttga agacgtggct gtgaaattta      240

cccaggagga atggaatctc cttagtgagg ctcagagatg cctgtaccgt gatgtgacgc      300

tggagaacct ggcacttatg tcctccctgg gttgttggtg tggagtggaa gatgaggcgg      360

caccttctaa gcagagtatt tatatacaaa gagagactca ggtcaggact cctatggcag      420

gtgtgtctcc caagaaggcc cacccctgtg agatgtgtgg cccgatcttg ggagacattt      480

tgcatgtggc agatcatcag ggaacacatc acaagcagaa actgcacagg tgtgaggcct      540

gggggaataa attgtatgac agtggaaact ttcatcagca ccagaatgag cacattggag      600

agaaacccta cagagggagt gttgaggagg cgttgtttgc gaagaggtgt aagttgcatg      660

tgtcagggga gtcatctgtc ttcagtgaga gtgggaaaga ctttttgctc aggtcaggat      720

tactccagca agaggccact cacactggga agtcaaacag caaaactgag tgtgtgtctc      780

tgtttcatgg gggaaaaagc cattacagct gtggaggatg catgaaacat tttagcacca      840

aagatatact cagtcagcac gagagactgc tccctacaga agaaccttct gtgtggtgtg      900

aatgtgggaa atcctctagc aaatatgaca gcttcagtaa tcatcaagga gttcacacta      960

gagaaaaacc ttatacgtgt gggatatgtg ggaaattatt taacagtaag tcccacctcc     1020

ttgtacacca gagaattcac actggagaga agccatatga gtgtgaggtt tgtcagaaat     1080

tttttaggca caagtaccac ctcattgcac accagagagt tcacactgga gaaaggccat     1140

atgaatgcag tgattgtggg aagtcattta cccacagctc tacattccgt gttcataaga     1200

gagttcacac tggtcagaag ccttatgagt gcagtgaatg tgggaaatct tttgccgaaa     1260

gctccagtct cactaaacac aggagagttc acactggaga aaagccttac gggtgcagtg     1320

aatgtgaaaa aaaatttagg caaatctctt cacttcgtca tcatcagaga gttcacaaaa     1380

gaaagggctt atgagtgcag tgagtccagt ctcattaaat attggagaat acacacctga     1440

gtaagatcct gtgattgcag caaatgtgga aaatgtttac ccaaaggtct gctctccttg     1500

gatattggag agttcacact agagaagagt ccttacaagt aaaataaatt tgggcagttt     1560

tgtagccaca cctctgtatt ccttcaggat tatagttaac actgaatgaa ggccttacta     1620

gtgtgacaaa tacaggatat ttatccagaa gtctggctgc ataactcaca ggagagctgt     1680

catgtgggag gattgctaca tgggaggatt tgcttgagcc tgggaggcag aggttgcagt     1740

gagccgagat tgcaacactg cagtccagtc tggaccacag agtgagaccc tgtttcaaaa     1800

ataaaatata taaatgacat ccaataaagt atgcatattt gagctgtagg ataagtcttg     1860

aattttcttt ttcttttttt tgagacagcc tcgctctgtc acccaggctg gagtacagtg     1920

gcataatctc ggctcactgc aagccctgcc tcctgggttc atgccattct cctgcctcag     1980

cctccctaat agctgggact acaggcaacc accaccactc ctaccttttt tgtattttta     2040

gtagagatgg ggtttcaccc tgttagccag gaagttctca atctcctgac ctcgtgatct     2100

gcccgccttg gcctctcaaa gtgttgggat tgcaggcgtg agccactgct cctggcttga     2160

attttcttat aatcccatga aaccatcatc agagtcacaa taatgaattt atctaatcta     2220

tcacctttgt attcacctgg agcctttata aagtttttct ctatgcagac aaccattgat     2280

ttactctgct gtataatact ttccattttc tagaattttc tgactgatgt aataaagtgt     2340

ttcctcttat aa                                                         2352


<210>  8
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ala Ala Ala Leu Arg Phe Pro Val Gln Gly Thr Val Thr Phe 
1               5                   10                  15      


Glu Asp Val Ala Val Lys Phe Thr Gln Glu Glu Trp Asn Leu Leu Ser 
            20                  25                  30          


Glu Ala Gln Arg Cys Leu Tyr Arg Asp Val Thr Leu Glu Asn Leu Ala 
        35                  40                  45              


Leu Met Ser Ser Leu Gly Cys Trp Cys Gly Val Glu Asp Glu Ala Ala 
    50                  55                  60                  


Pro Ser Lys Gln Ser Ile Tyr Ile Gln Arg Glu Thr Gln Val Arg Thr 
65                  70                  75                  80  


Pro Met Ala Gly Val Ser Pro Lys Lys Ala His Pro Cys Glu Met Cys 
                85                  90                  95      


Gly Pro Ile Leu Gly Asp Ile Leu His Val Ala Asp His Gln Gly Thr 
            100                 105                 110         


His His Lys Gln Lys Leu His Arg Cys Glu Ala Trp Gly Asn Lys Leu 
        115                 120                 125             


Tyr Asp Ser Gly Asn Phe His Gln His Gln Asn Glu His Ile Gly Glu 
    130                 135                 140                 


Lys Pro Tyr Arg Gly Ser Val Glu Glu Ala Leu Phe Ala Lys Arg Cys 
145                 150                 155                 160 


Lys Leu His Val Ser Gly Glu Ser Ser Val Phe Ser Glu Ser Gly Lys 
                165                 170                 175     


Asp Phe Leu Leu Arg Ser Gly Leu Leu Gln Gln Glu Ala Thr His Thr 
            180                 185                 190         


Gly Lys Ser Asn Ser Lys Thr Glu Cys Val Ser Leu Phe His Gly Gly 
        195                 200                 205             


Lys Ser His Tyr Ser Cys Gly Gly Cys Met Lys His Phe Ser Thr Lys 
    210                 215                 220                 


Asp Ile Leu Ser Gln His Glu Arg Leu Leu Pro Thr Glu Glu Pro Ser 
225                 230                 235                 240 


Val Trp Cys Glu Cys Gly Lys Ser Ser Ser Lys Tyr Asp Ser Phe Ser 
                245                 250                 255     


Asn His Gln Gly Val His Thr Arg Glu Lys Pro Tyr Thr Cys Gly Ile 
            260                 265                 270         


Cys Gly Lys Leu Phe Asn Ser Lys Ser His Leu Leu Val His Gln Arg 
        275                 280                 285             


Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Glu Val Cys Gln Lys Phe 
    290                 295                 300                 


Phe Arg His Lys Tyr His Leu Ile Ala His Gln Arg Val His Thr Gly 
305                 310                 315                 320 


Glu Arg Pro Tyr Glu Cys Ser Asp Cys Gly Lys Ser Phe Thr His Ser 
                325                 330                 335     


Ser Thr Phe Arg Val His Lys Arg Val His Thr Gly Gln Lys Pro Tyr 
            340                 345                 350         


Glu Cys Ser Glu Cys Gly Lys Ser Phe Ala Glu Ser Ser Ser Leu Thr 
        355                 360                 365             


Lys His Arg Arg Val His Thr Gly Glu Lys Pro Tyr Gly Cys Ser Glu 
    370                 375                 380                 


Cys Glu Lys Lys Phe Arg Gln Ile Ser Ser Leu Arg His His Gln Arg 
385                 390                 395                 400 


Val His Lys Arg Lys Gly Leu 
                405         


<210>  9
<211>  5794
<212>  DNA
<213>  Homo sapiens

<400>  9
gattggtgtt gggtttattt gtcggagagg ctcctgagcg ctaggtcggc actgcggtga       60

ctgaacccag aaggcggaga acagttgtcc tctgctgcac agaggcgact ctggagctct      120

gtgacggcgc caagcgtgac ccacccctgg gccaggatag ggaccgtcat gcccatatct      180

cctggctggt caccctctcc tcccaaccct gctttaaacc acgtggttcg atggcggtgg      240

tggccacgct gaggctctct gctcagggca cagtgacttt tgaagacgtg gctgtgaaat      300

ttacccagga ggaatggaat ctccttagtg aggctcagag atgcctgtac cgtgatgtga      360

ctctggagaa cctggcactt atgtcctccc tgggttgttg gtgtggagtg gaagatgagg      420

cggcaccttc taagcagagt atttatatac aaagagagac tcaggtcagg actcctgtga      480

caggtgtgtc tcccaagaag gcccacccct gtgagatgtg tggcccgatc ttgggagaca      540

ttttgcatgt ggcagatcat cagggaacac atcacaagca gaaactgcac aggtgtgagg      600

cctgggggaa taaattgtat gacagtggaa actttcatca gcaccagaat gagcacattg      660

gagagaaacc ctacagaggg agtgttgagg aggcgttgtt tgtgaagagg tgtaagttgc      720

atgtgtcagg ggagtcatct gtcttcagtg agagtgggaa ggactttttg cccaggtcag      780

gattactcca gcaggaggcc agtcacactg gggagaagtc aaacagcaaa actgagtgtg      840

tgtctccctt tcagtgtggg ggagctcact atagccatgg agattccatg aaacatttta      900

gcaccaaaca tatactcagt cagcaccaga gacttctccc tcgagaagaa tgttatgtgt      960

gctgtgaatg tgggaaatcc tttagcaaat atgttagctt cagtaatcat cagagagttc     1020

acagtggaaa aagaccttat gaatgtggag aatgtgagaa atcttttagt caaaagagca     1080

gcctcattca acatcagcaa tttcacactg gaggaaaacc ttatgggtgt gaagaatgtg     1140

ggaaatattt tagcttagaa ggatatctta ggcgccatca aaaagttcac gctggaaaag     1200

ggccttatga gtgtggagaa tgtgggaaat cttttagttc aaacgtgaac cttaagagtc     1260

atcagcgcat tcacactgga gagagacctt acaagtgtgg agaatgtgag aaatctttta     1320

gtcggaagcc cagccttagt taccatcagc gcattcacac tgaagtaaga ccttacaagt     1380

gtggagaatg tgggaaatct tatatttcaa aggggcacct taggatccat cagcgcatgc     1440

acactggaga aagaccttac aagtgtggag actgtgggaa atcttttaat gaaaaaggac     1500

accttaggag tcatcagcga gttcacacta cagaaagacc ttataagtgt ggggaatgtg     1560

ggaaatgttt tagtcacaag ggtaacctca ttctacacca gcatggccat actagaaaaa     1620

ggccttatat gtgttgggaa tgtggaaaat tatttaagaa gaagtctcac ctccttgtac     1680

accagagaat tcacagtgga gagaagccat atgcttgtga ggcttgtcag aaatttttta     1740

ggcacaagtg ccacctcact gcacaccaga gagttcacac tggagaaagg ccatatgaat     1800

gcagtgattg tgggaagtca tttacccaca gctgtgcatt cattgttcat aagagagttc     1860

acactggtca gaagccttat gagtgcagtg aatgtgggaa atcttttgct gcaagctcct     1920

atctcactag tcacaggaga gttcacactg gtcagaagcc ttatgagtgc agtgaatgtg     1980

ggaaatcttt tgctggaatc tccagtctca ctaatcacag gagagttcac actggagaaa     2040

agccttatgg gtgtagtgaa tgtgaaaaaa aatttaggaa aagctcttca cttcgttacc     2100

atcagagagt tcatgaaaga aaggccttat gagtgcagag aatgagtcca gtctcattaa     2160

atacaggaga gcacacacct gagtaagatc ttgtgattgc agcaaatgtg gaaaatgttt     2220

acccaaaaga agtctgctct ccttggacat tggagagttc acaccagaga aaagtcctta     2280

caagtaaaat aaatttggca gttttgtagc cacacctctg tattccttca ggattatatt     2340

taacactgaa tgaaggcctt actagtgtgg caaatatagg ctatttatcc agaagtctgg     2400

cttcaaaact cacaggagag ctgtcactac ggaaatgcct tttgaatgta atgtttgcaa     2460

aaaagcactg tgccttctgt cattgaatcc tagaacactg agatgagaaa aacactgtag     2520

atgtataggt tagatatata gggaatgtta ttattttttc ctttttttgg agagacggtc     2580

tcactccatc acccatgctg gtgtgcagtg ctgcgatcgt agctcactgc atcctccgcc     2640

ccctaggctc aagtgatctt cccaccttag cctccatgta gctgggtcca caggcatgca     2700

ccaccatgcc tggctatttt ctcatattag tagatatagg gttttaccat gtttccaggc     2760

tggtatcgaa ctcctgagct caagcaatct gtacacctca gcctcccaaa gtgctgagat     2820

tgtaggtttg agtcactgtg ctcagccaat tatgtttttc tgtgtaacat gggaggagat     2880

cctttgaggg caccatgtgc ccaaattgaa aaaactccag gcatgtggca tctgtattat     2940

attttttact atgccctgtt atcttgctag acttatgtga ctgccactta tctggcaaaa     3000

gccattacat ctcagctact tggtaggtac ccacattgca tcattcacct atttcgtatt     3060

ctagaagtat attttggttg tctcccattc acgagagatt ttttttttaa gttttttgtt     3120

tggttggttg gttggttggt tggttgtttt tttttgtttt tttttttttt ttttttggag     3180

acaaagtttc actgtcaccg atactggagt gcagtggtgt gatcctggtt cattgcaacc     3240

tctgcctcct gagttcaagc aattctcctt tctcagcctc ctgagtagct gggattacag     3300

gtgcctgcca ccacacccag gtaatttttg tacttttagt agagatgggg tttcactatg     3360

ttggtcaaac tgatcttgaa ctcctaacct cgtgatccac ctgccttggc ctcccaaagt     3420

gctgggatta cagtgtgagc ctctgcttct ggccttttta aaaatttttt aaatttatat     3480

tttttgtaga gacagggtct tgctgtgttg cacagtctgg tctcaaactg ctggtctcga     3540

gtgatccttc tgcctggctt cccagaatgt tgggattata ggcgtggcat aagtcaccat     3600

gctgggactt ttttatttct ttaattttta attccagatc tggtcacaga aggatttgtt     3660

gagtagcctc agcacttctt gctttttcat ttctttctga taagttacac catggacctt     3720

ccccattttt gtcccagagg actcttgtgc tgacttgaaa agatggacta ttttggctaa     3780

gcatggtggc tcatgcctgt aatcccaaca ctttgggagg ccgaggtggg tggatcacaa     3840

ggacaggaag gagttcaaga ccagcctggg caatatagtg aaatcctgtc tcttctaaaa     3900

atataaaaat tagccgggca tggtggcgca cctgtagccg cagctactca ggaggctgag     3960

gcaggaaaat tgcttgaacc ccgggaggta gaggttgcag tgagctgaga tcatgccact     4020

gcactccagc ctgggtcctg ctaccttgaa ggacagcata gctaaactgc gtggcccaag     4080

ggacagcatg aatgcagaat atagctttct tcacttgtgg cctatttgca tagctgccca     4140

aggcctccag tggacgactt catggctttg tggtcttcat ctgtagcatg gatactacag     4200

attgtgggtt cataggtcag ctgggtacag ggcagttttt ataacaacct ctggtgggtt     4260

ttttatttta gtgtcaatat cacactgaaa gattggtgat tttttttgaa ccagacaaaa     4320

ttctctctta tgaggtatat tgcactgtgc tcggtactgt tgagggaact ctgttcagca     4380

gatcttacaa ggcacacatg tgccatgata tccagaattc tgtaaggcaa catcacaggt     4440

tgtaaggcta taggatgaaa ttataatttt atggttactt agttactgca tttatagtca     4500

gcagagggga cagcaataaa gtttttgaaa tatatctttt tttttttttt gagacacagt     4560

ctcactctgt cacccaggct agagtgctgt tgcaccatct cggctcactg caacctgtgc     4620

cttctgggtt caagcgattc tcccacctca gtcacccaag tagctagaat tacaggtgca     4680

tgccaccaca ccactaatgt tttgtggttt tagtagagac gggtttcacc gtgttgcaca     4740

gactggtctt gaattcaact cttgagctca ggtgatctgc tcacctccgc cttccaaagt     4800

gctgggacta caggtgtggg ccgctgtgtt tggctgaaat gtatgtcttt taaaggagtg     4860

tccacagtta tccagtcact gtgtctgtga tggataagca gatacagaaa ttctcaagac     4920

ttccataata atgaatgttg tgtagctaag ctttggtcag aggaaataat ctaaaggttt     4980

tgtgaattca tgtaaccttt tgggctgctc accttaaggt aactcctgta ttaacaggag     5040

gaacagaata gggaaaaaga tctcagttca gtgatgtagc tttgtgacca gccagtgatc     5100

cagttcaatc aggtagaaat gaccttcctg ctacatcaat atttgcttct atggaggcta     5160

gtttccccac ttagggcatg agaagaattg gtaaagtcaa cataaaattg ccaaacctgt     5220

caccaaaaat gatggcaaat ctgtattttt ctcttaaacc gtgttataaa agctgtaata     5280

aggtataggc tgagcatcat ggctcatgcc tgtattccca gcactttggg aggccagatt     5340

ccttgagacc agtgtgggga acatggcaaa accttgtctc taggaaaaat agccaggtat     5400

ggtggcatgt accttagtct tagtgatgtg ggaggattgc ttgagcctgg gaggcagaag     5460

ttgcagtgag ctaagattgc aacgctgcag tccagcctgg gtgatagagt gagaccccat     5520

cttaaaaata aaataaagat ataaatgaca tccaataaag tacacatatt tgagctgtag     5580

gataagtctt gaattttatt ataatcccgt gaaaccatca tcagagtcac cataatgaat     5640

ttatctaatc tatcaccttt gtatttactt ggagccttta taaagttttt ctctctgctc     5700

ttcaaacaac cattgattta ctttgctgta tgatggagta ctttccattt tctggaattt     5760

tctgactgat gtaataaagt gtttcctctt ataa                                 5794


<210>  10
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Val Val Ala Thr Leu Arg Leu Ser Ala Gln Gly Thr Val Thr 
1               5                   10                  15      


Phe Glu Asp Val Ala Val Lys Phe Thr Gln Glu Glu Trp Asn Leu Leu 
            20                  25                  30          


Ser Glu Ala Gln Arg Cys Leu Tyr Arg Asp Val Thr Leu Glu Asn Leu 
        35                  40                  45              


Ala Leu Met Ser Ser Leu Gly Cys Trp Cys Gly Val Glu Asp Glu Ala 
    50                  55                  60                  


Ala Pro Ser Lys Gln Ser Ile Tyr Ile Gln Arg Glu Thr Gln Val Arg 
65                  70                  75                  80  


Thr Pro Val Thr Gly Val Ser Pro Lys Lys Ala His Pro Cys Glu Met 
                85                  90                  95      


Cys Gly Pro Ile Leu Gly Asp Ile Leu His Val Ala Asp His Gln Gly 
            100                 105                 110         


Thr His His Lys Gln Lys Leu His Arg Cys Glu Ala Trp Gly Asn Lys 
        115                 120                 125             


Leu Tyr Asp Ser Gly Asn Phe His Gln His Gln Asn Glu His Ile Gly 
    130                 135                 140                 


Glu Lys Pro Tyr Arg Gly Ser Val Glu Glu Ala Leu Phe Val Lys Arg 
145                 150                 155                 160 


Cys Lys Leu His Val Ser Gly Glu Ser Ser Val Phe Ser Glu Ser Gly 
                165                 170                 175     


Lys Asp Phe Leu Pro Arg Ser Gly Leu Leu Gln Gln Glu Ala Ser His 
            180                 185                 190         


Thr Gly Glu Lys Ser Asn Ser Lys Thr Glu Cys Val Ser Pro Phe Gln 
        195                 200                 205             


Cys Gly Gly Ala His Tyr Ser His Gly Asp Ser Met Lys His Phe Ser 
    210                 215                 220                 


Thr Lys His Ile Leu Ser Gln His Gln Arg Leu Leu Pro Arg Glu Glu 
225                 230                 235                 240 


Cys Tyr Val Cys Cys Glu Cys Gly Lys Ser Phe Ser Lys Tyr Val Ser 
                245                 250                 255     


Phe Ser Asn His Gln Arg Val His Ser Gly Lys Arg Pro Tyr Glu Cys 
            260                 265                 270         


Gly Glu Cys Glu Lys Ser Phe Ser Gln Lys Ser Ser Leu Ile Gln His 
        275                 280                 285             


Gln Gln Phe His Thr Gly Gly Lys Pro Tyr Gly Cys Glu Glu Cys Gly 
    290                 295                 300                 


Lys Tyr Phe Ser Leu Glu Gly Tyr Leu Arg Arg His Gln Lys Val His 
305                 310                 315                 320 


Ala Gly Lys Gly Pro Tyr Glu Cys Gly Glu Cys Gly Lys Ser Phe Ser 
                325                 330                 335     


Ser Asn Val Asn Leu Lys Ser His Gln Arg Ile His Thr Gly Glu Arg 
            340                 345                 350         


Pro Tyr Lys Cys Gly Glu Cys Glu Lys Ser Phe Ser Arg Lys Pro Ser 
        355                 360                 365             


Leu Ser Tyr His Gln Arg Ile His Thr Glu Val Arg Pro Tyr Lys Cys 
    370                 375                 380                 


Gly Glu Cys Gly Lys Ser Tyr Ile Ser Lys Gly His Leu Arg Ile His 
385                 390                 395                 400 


Gln Arg Met His Thr Gly Glu Arg Pro Tyr Lys Cys Gly Asp Cys Gly 
                405                 410                 415     


Lys Ser Phe Asn Glu Lys Gly His Leu Arg Ser His Gln Arg Val His 
            420                 425                 430         


Thr Thr Glu Arg Pro Tyr Lys Cys Gly Glu Cys Gly Lys Cys Phe Ser 
        435                 440                 445             


His Lys Gly Asn Leu Ile Leu His Gln His Gly His Thr Arg Lys Arg 
    450                 455                 460                 


Pro Tyr Met Cys Trp Glu Cys Gly Lys Leu Phe Lys Lys Lys Ser His 
465                 470                 475                 480 


Leu Leu Val His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Ala Cys 
                485                 490                 495     


Glu Ala Cys Gln Lys Phe Phe Arg His Lys Cys His Leu Thr Ala His 
            500                 505                 510         


Gln Arg Val His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Asp Cys Gly 
        515                 520                 525             


Lys Ser Phe Thr His Ser Cys Ala Phe Ile Val His Lys Arg Val His 
    530                 535                 540                 


Thr Gly Gln Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ser Phe Ala 
545                 550                 555                 560 


Ala Ser Ser Tyr Leu Thr Ser His Arg Arg Val His Thr Gly Gln Lys 
                565                 570                 575     


Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ser Phe Ala Gly Ile Ser Ser 
            580                 585                 590         


Leu Thr Asn His Arg Arg Val His Thr Gly Glu Lys Pro Tyr Gly Cys 
        595                 600                 605             


Ser Glu Cys Glu Lys Lys Phe Arg Lys Ser Ser Ser Leu Arg Tyr His 
    610                 615                 620                 


Gln Arg Val His Glu Arg Lys Ala Leu 
625                 630             


<210>  11
<211>  6885
<212>  DNA
<213>  Homo sapiens

<400>  11
agtagcggct gtgtatcggc gatgcgggtg tttccccagt ttgtggcccc tgagtgctgg       60

gtgggaccgc ggtgactgaa cctagaaggt ggagaggaat cgtcctcggt gcccagaggc      120

ggctctgcag ccccgtgacg gcgaccactg ctcccgggcc gtgcttcccc aagtagtccg      180

atggcagcgg ctgtgccgag gcgcccaact cagcagggca ctgtgacctt tgaagatgtg      240

gctgtgaact tttcccagga ggagtggtgt cttcttagtg aggctcagag gtgcttgtac      300

cgtgatgtga tgctagagaa cctggctctc atatcctcgc tgggttgttg gtgtggatca      360

aaagatgagg aggcaccttg taagcagaga atttctgtac aaagagagtc tcagagcagg      420

actcctaggg caggtgtttc tcctaagaag gctcacccct gtgaaatgtg tggcctcatc      480

ttggaggatg tttttcactt tgctgaccac caggaaactc atcacaagca gaagctgaac      540

aggagtggag catgtggaaa aaacttggat gacactgcat accttcatca gcaccagaag      600

cagcatattg gagagaaatt ctacagaaag agtgtcagag aagcatcgtt tgtaaagaaa      660

cgtaagctca gggtgtcaca ggagccattt gtcttccgcg agtttgggaa ggacgttctg      720

cccagttcag gattgtgcca agaagaagct gctgtagaga agacagacag tgaaactatg      780

catggcccac cctttcagga gggaaaaact aattacagtt gtggaaaacg cacaaaagcc      840

ttcagcacca aacactcagt tattccacac cagaaacttt tcactagaga tggatgttat      900

gtgtgcagtg attgtggaaa atcctttagc agatatgtca gcttcagtaa tcatcagcga      960

gatcacactg caaaaggacc ttatgattgt ggagagtgtg ggaaatctta tagtcgaaag     1020

agcagcctta ttcaacatca gcgagtccac actggacaga cagcttatcc ctgtgaggag     1080

tgcgggaaat cttttagtca gaagggcagc cttattagcc atcagcttgt tcacactgga     1140

gaagggcctt atgagtgtag agaatgtggg aaatcttttg gtcaaaaggg taacctcatt     1200

caacatcagc aaggtcacac tggagagaga gcttatcact gtggggaatg tgggaaatct     1260

tttcgtcaga agttctgctt tattaaccat cagcgtgttc acactggaga aaggccttac     1320

aagtgtggag aatgtgggaa atcttttggt caaaagggca acctcgttca ccatcagcga     1380

ggtcatactg gagaaaggcc ctatgagtgc aaggaatgtg ggaaatcatt taggtacaga     1440

tcccacctca ctgaacacca gagacttcac actggggaaa gaccttacaa ttgtagggaa     1500

tgtgggaaat tatttaacag gaagtatcat cttctggttc atgagagagt tcacactgga     1560

gaaaggccat atgcgtgtga ggtatgtggg aaattatttg gcaataagca cagcgtgact     1620

atacatcaga ggattcacac tggagaaagg ccgtatgaat gcagtgaatg tgggaaatca     1680

tttctttcca gctctgcgct tcatgttcat aaaagagttc attctggaca aaagccttat     1740

aagtgcagtg aatgtggaaa atccttttct gaatgttcca gtctcattaa acacaggaga     1800

attcacactg gagaaaggcc ttatgaatgc accaaatgtg gaaaaacatt tcagcgaagc     1860

tctaccctcc ttcatcatca gagttcacac aggagaaagg ccttatgagt gcagtgaata     1920

tgggaaatcg tttgctgaag catcccgtct cgttaaacac aggagagttc atactggaga     1980

aaggccttat gagtgctgtc aatgtggaaa acatcagaat gtctgctgtc ctcggtctta     2040

agcgacttcg tgttgagatg gagtcttgtt ctgtcaccca ggctggagtg cagtggtgca     2100

gtcttggctc gctgcaactt gggcctcctg ggttcatgca atcctcctac ctcagcctcc     2160

tgagtagctg ggattatgag tacacaccac cacgcccagc taatttttgt gtttttagtg     2220

gagatggggt tttaccatgt tggccaggct ggtctcaaac tcctgacctc aagtgatcca     2280

cccaccttga ctcccaaagt gctgaaatta caggcatgag cctctgcacc tggccttcat     2340

tcttttcgta ttgcttagaa tatgacatgc tgaaccaggc atggtggctc atgcttgtaa     2400

acctgatgct ttgggaggac aaggtggttc attggaggcc aggagttaga gatcagcctg     2460

ggcaacatag ccagacctcc tctctacaaa aagaaaaaag aatgacatgc ttcttgtttt     2520

tgtctgttat aaatgaaact gctatatttg aatgcagttg ttcatgtagg tatgtttcac     2580

tatggtaata tggtggtgtg cagtgcctga gtcacgtgat agattaaagt acaactcttt     2640

tttgagacag agtctcactc tgtcacccag gcgggagtta ggtggcatga tttcggctca     2700

ctgcaacctc tgcctcccaa gttcaactga ttcttctgcc tcagcctccc gagtagcagg     2760

gattaccggt gtgcaccacc atgcctggat aacttttttt tttatttcta ttagcaatgg     2820

ggtttcacca tgctggccag gcttgttatg aactgacctc aagtgatctg cctgcctcag     2880

cttctcaggt gtgacctact gtgcttggcc taatgtacaa ctttttaagc aatgccaaac     2940

tatgacttaa gaatgaaatt attgctcatt tgtatatcta tctaccatca gtgtccaaga     3000

atttctgttc tatcttacca agagggagta tggttagtat ttgaaattgt ttattatttt     3060

aataagtggt tataactttt gagtcagtgg tttatgtttt gcattttttt tgttttgaga     3120

caaagtctcg ctctgtctcc caggctagag taccgtggca caatctcagc tcattgcaac     3180

ctctgcttcc tgggctcaag cactctgccc acctcagcct ccagagtagc tggaaataca     3240

ggtatgcacc accacaactg gataactttt gtattttctg tagagagggt tttacctttt     3300

tgcccagtct gatcgcgaac tcctgggctc aggcgatcca cttgcctagg ctccaaaagt     3360

gcttggtcta caggggtgag gcaccctgcc tggcctcacc tgtaggcttg ttttttaaaa     3420

tgaattttat ctatttccca tttcattaat atatttaaaa ataatgaaat aacaaagacg     3480

tatgttggac ttcattcatt cttcagtgat gtcactttgc tgcaaggaat atttggtttt     3540

cttttttttt tttttttcca gatggagtct agctctgtct cctaagctac agtgaagtgg     3600

catgatctcg gcccactgca acctccacct cctgtgttca agcgattctg cctcagcctc     3660

ctgagtagct gggactacag gcatgtgcca ttatacctgg ctaattttat ttatttattt     3720

tagtagagat ggggtttcac catgttaccc aggctgctct ctaccttctg agctcaagtg     3780

atccacctgc ctcggcctcc caaagtgctg ggattacagg tgtcagccac tgtacctggc     3840

tgaatacttg gttttcagta ccacaagaac tatgagctgg ttatccactt catgtggaat     3900

cataagcgtc ccaaagtgac aatacatata gattgccagg cagtgaaaca gttaagatgc     3960

caccatagct ttcttttcaa catctttcta agattacctt actatttctt ttgttccaag     4020

tttgtacttc ctcacagttc tcacatatgg aaaggataca cactttgtag aaacaagaac     4080

tttatgttat ccaagttcta ggatagccat gagctccaat tatctcagag ctctgagtcc     4140

tctactcaat acccattgag atttatgtgt tctgaggctt ttgtcttcta gctacttact     4200

tcattctcca tgggtaacgt cattcatcca cattaactaa tttcctcact ccaagctctt     4260

ttctagagat aatctccagt ccctgtgcag aaactgtcat tgcactttct gctgaaatgg     4320

cagtttcttc tcagcaaggt gagattatgg aatccagaat cttttttcag gggtcacatg     4380

cccatttccc cacttgcatg aatgtcgaca ctgcagccac agttttggcc gtaaatgtga     4440

atttggcaag taaccactgt tcccagggaa atgtcccaat cagaagaaga ttatctggga     4500

cactgatact gacagggaga tgggacattc tgagggaccc ggaggcaggg tgccacctcc     4560

tcaacttccc tgagggctgc ctagaatctg tttcctctca ctctgaatta ttcttcctct     4620

tatggctgac caaaaacatg gaacctcaca aagtccactg taacagcttt atatttgtga     4680

agtgaagaac atgaagacag tttcaagcaa agttattgag tggacacttt gtgttttttt     4740

tgagaagtct cactctttca cccaggctgg agtgcagtgg cacgatctcg gctcactgca     4800

actccacctc ccgggttcac gccattctct tgcctcagcc tcctgagtag ctgggaccac     4860

aagcgcccac cacgtcagct taattttttt gttttgtttc ttgagacaga gtcttgctct     4920

cttgcccagg ttggagtgcc gtgtcgcaat ctcagctcac tgcaacttct acctcctgga     4980

ttcaagcact tctccttgcc tcagccacct ctttagctgg gattacaggt gcgtgccacc     5040

acacccagct aatttttgta tttttagcag agaccaggtt tcaccatgtt ggtcaggctg     5100

gtctcaaact cctgacctcg tgatccaccc acctcggcct cccaaagtgc tggaattaca     5160

ggcgtgagcc actgcacctg gcctgtattc ttttctttag tagagacggg gttttactgt     5220

atttgccagg atggtctcga tctccagacc tcgtgatccg cccgccttag cctcccaaag     5280

tgctgggatt ataggcgtga gccaacacgc cctggccact tcttgtcttt gcaacatttt     5340

ttagatatgt atttgtgttt tttggggagc ttaatttgct aatggaatct ctgttatttt     5400

cctaacatgc ttggtggata caagagttaa gacttcctgt cccgtttagt gtaacaaaag     5460

aaagttaaga aatgtggata aaagattgta agttagaaat ggcaagataa tcagctatat     5520

gaagaatctt ggccaggtgt ggtggctgag gcctgtaatc ccaccacttt gggaggctga     5580

ggtgggcgga tcacaaggtc aggagttcaa gaccaccctg gccaatattg tgaattcctg     5640

tctctactaa aaatacaaaa attagtcggg catggtggcg ggtgcctgta gtcccagcta     5700

ctcgggaggc tgaggccaga aaatcggttg aacctgggag gtggaaggtg cactgagcca     5760

atatcacacc agtgcactcc aacctggtga cagagagaca catcatctca aaaaaaaaaa     5820

aaaaactcaa tccataaatg ttatacttta taactttata acagcatgtt atatgggctt     5880

agatattatc cctaaatttt tttttttttt tttttttttg agacagagtc tcactctgtc     5940

acccaggctg aagtgcaatg gcatggtctc ggctcactgc aacctccgcc tcccaggttc     6000

aagtgattct cttgcctcag cctcccgagt agctgggcct ataggttccc tccaccacgc     6060

ccagctaatt tttgtatttt tagtagagat gggctttcac tacgttagcc aggctggtct     6120

caaactcctg acctcatgat ccacccccct cggcctccta aagtgctggg attacaggca     6180

tctgccaccg cactcggctt atccctagaa atcctatgat agcatgatgt ataggcacct     6240

aaaggcatgg cacttgagaa atgtgaataa gattgtaagt tacaaatagc aaggtacagt     6300

cagatgttaa cagtctcagc ccctaaatgt caccttgtat tacagcatgt tatataagca     6360

catacaggca catacatgaa atagtgatac ttcattctca gtaatatctt catccttctc     6420

actggaaaga tctttgatga tttttaatca acataggagt ttcaatgata tctagaagtt     6480

taaaagggct cgttcaaaca aattatgacc acacacactg aagagtatgt ttgtctcttg     6540

tggtgtaaat ttttttttat tacaccaaat tatgttcaca caaaaccttt gtaatcaggg     6600

ggaattaaag agccttcctg gaaaatggag gttgcaatca gccgagatgg tgccatcgca     6660

ctctagcctg gggaatagag tgagatcctg cctcaaaaaa aacaaaaaaa ttctttattt     6720

tctccataaa ctacagttta tataagcaaa agtttcagta ctaagcaatt ttagtctctg     6780

cagtctcttg tcttgaatta atacaacttt tgttaattct cttatgaagt taatcttcct     6840

gcttgtatgt gaattaaata tatgtcaaac tttttttgta caaaa                     6885


<210>  12
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ala Ala Val Pro Arg Arg Pro Thr Gln Gln Gly Thr Val Thr 
1               5                   10                  15      


Phe Glu Asp Val Ala Val Asn Phe Ser Gln Glu Glu Trp Cys Leu Leu 
            20                  25                  30          


Ser Glu Ala Gln Arg Cys Leu Tyr Arg Asp Val Met Leu Glu Asn Leu 
        35                  40                  45              


Ala Leu Ile Ser Ser Leu Gly Cys Trp Cys Gly Ser Lys Asp Glu Glu 
    50                  55                  60                  


Ala Pro Cys Lys Gln Arg Ile Ser Val Gln Arg Glu Ser Gln Ser Arg 
65                  70                  75                  80  


Thr Pro Arg Ala Gly Val Ser Pro Lys Lys Ala His Pro Cys Glu Met 
                85                  90                  95      


Cys Gly Leu Ile Leu Glu Asp Val Phe His Phe Ala Asp His Gln Glu 
            100                 105                 110         


Thr His His Lys Gln Lys Leu Asn Arg Ser Gly Ala Cys Gly Lys Asn 
        115                 120                 125             


Leu Asp Asp Thr Ala Tyr Leu His Gln His Gln Lys Gln His Ile Gly 
    130                 135                 140                 


Glu Lys Phe Tyr Arg Lys Ser Val Arg Glu Ala Ser Phe Val Lys Lys 
145                 150                 155                 160 


Arg Lys Leu Arg Val Ser Gln Glu Pro Phe Val Phe Arg Glu Phe Gly 
                165                 170                 175     


Lys Asp Val Leu Pro Ser Ser Gly Leu Cys Gln Glu Glu Ala Ala Val 
            180                 185                 190         


Glu Lys Thr Asp Ser Glu Thr Met His Gly Pro Pro Phe Gln Glu Gly 
        195                 200                 205             


Lys Thr Asn Tyr Ser Cys Gly Lys Arg Thr Lys Ala Phe Ser Thr Lys 
    210                 215                 220                 


His Ser Val Ile Pro His Gln Lys Leu Phe Thr Arg Asp Gly Cys Tyr 
225                 230                 235                 240 


Val Cys Ser Asp Cys Gly Lys Ser Phe Ser Arg Tyr Val Ser Phe Ser 
                245                 250                 255     


Asn His Gln Arg Asp His Thr Ala Lys Gly Pro Tyr Asp Cys Gly Glu 
            260                 265                 270         


Cys Gly Lys Ser Tyr Ser Arg Lys Ser Ser Leu Ile Gln His Gln Arg 
        275                 280                 285             


Val His Thr Gly Gln Thr Ala Tyr Pro Cys Glu Glu Cys Gly Lys Ser 
    290                 295                 300                 


Phe Ser Gln Lys Gly Ser Leu Ile Ser His Gln Leu Val His Thr Gly 
305                 310                 315                 320 


Glu Gly Pro Tyr Glu Cys Arg Glu Cys Gly Lys Ser Phe Gly Gln Lys 
                325                 330                 335     


Gly Asn Leu Ile Gln His Gln Gln Gly His Thr Gly Glu Arg Ala Tyr 
            340                 345                 350         


His Cys Gly Glu Cys Gly Lys Ser Phe Arg Gln Lys Phe Cys Phe Ile 
        355                 360                 365             


Asn His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Lys Cys Gly Glu 
    370                 375                 380                 


Cys Gly Lys Ser Phe Gly Gln Lys Gly Asn Leu Val His His Gln Arg 
385                 390                 395                 400 


Gly His Thr Gly Glu Arg Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser 
                405                 410                 415     


Phe Arg Tyr Arg Ser His Leu Thr Glu His Gln Arg Leu His Thr Gly 
            420                 425                 430         


Glu Arg Pro Tyr Asn Cys Arg Glu Cys Gly Lys Leu Phe Asn Arg Lys 
        435                 440                 445             


Tyr His Leu Leu Val His Glu Arg Val His Thr Gly Glu Arg Pro Tyr 
    450                 455                 460                 


Ala Cys Glu Val Cys Gly Lys Leu Phe Gly Asn Lys His Ser Val Thr 
465                 470                 475                 480 


Ile His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu 
                485                 490                 495     


Cys Gly Lys Ser Phe Leu Ser Ser Ser Ala Leu His Val His Lys Arg 
            500                 505                 510         


Val His Ser Gly Gln Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys Ser 
        515                 520                 525             


Phe Ser Glu Cys Ser Ser Leu Ile Lys His Arg Arg Ile His Thr Gly 
    530                 535                 540                 


Glu Arg Pro Tyr Glu Cys Thr Lys Cys Gly Lys Thr Phe Gln Arg Ser 
545                 550                 555                 560 


Ser Thr Leu Leu His His Gln Ser Ser His Arg Arg Lys Ala Leu 
                565                 570                 575 


<210>  13
<211>  6244
<212>  DNA
<213>  Homo sapiens

<400>  13
attttgattg gtgttggatt tatttgtagg agaggctcct gagcgctagg tccgcactgt       60

ggtgactgaa cccagaagtc ggggagcagt tgtcctccgc tgcacagagg ctactctgga      120

gctctgtgac ggcgcccagc gtgacccact cctgggccag gatacggacc gtcgtgccca      180

tatctcctgg ctggtcgccc tatcctcccg actctgctta aaaccacgtg gttcgatggc      240

tgccgcggct acgctgaggc tctccgctca gggcacagtg acttttgaag atgtggctgt      300

gaactttacc tgggaggaat ggaatctcct tagtgaggct cagagatgcc tgtaccgtga      360

tgtgacgctg gagaacctgg cacttatatc ctccctgggt tgttggtgtg gagtggaaga      420

tgaggcggca ccttctaagc agagtattta tatacaaaga gagactcagg tcaggactcc      480

tatggcaggt gtgtctccca agaaggccca cccctgtgag atgtgtggcc cgatcttggg      540

agacattttg catgtggcag atcatcaggg aacacatcac aagcagaaac tgcacaggtg      600

tgaggcctgg gggaataaat tgtatgacag tggaaacttt catcagcacc agaatgagca      660

cattggagag aaaccctaca gagggagtgt tgaggaggcg ttgtttgcaa agaggtgtaa      720

gttgcatgtg tcaggggagt catctgtctt cagtgagagt gggaaggact ttttgcccag      780

gtcaggatta ctccagcagg aggccagtca cactggggag aagtcaaaca gcaaaactga      840

gtgtgtgtct cccattcagt gtgggggagc tcactacagc tgtggagaat ccatgaaaca      900

ttttagcacc aaacatatac tcagtcagca ccagagactg ctcactagag aagagtgtta      960

tgtgtgctgt gaatgtggga agtcctttag caaatatgct agcttgagta atcatcagag     1020

agttcacact gaaaaaaaac atgaatgtgg agaatgtggg aaatccttta gcaaatatgt     1080

tagcttcagt aatcatcaga gagttcacac tgaaaaaaaa catgaatgtg gagaatgtgg     1140

gaaatccttt agcaaatatg ttagcttcag taatcatcag agagttcaca ctgggaaaag     1200

accttatgaa tgtggagaat gtgggaaatc gtttagcaaa tatgctagct tcagtaatca     1260

tcagagagtt cacactgaaa aaaaacatta tgaatgtgga gaatgtggga aatcctttag     1320

caaatatgtt agcttcagta atcatcagag agttcacact gggaaaagac cttatgaatg     1380

tggagaatgt gggaaatcgt ttagcaaata tgctagcttc agtaatcatc agagagttca     1440

cactgacaaa aaacattatg aatgtggaga atgtgggaaa tcctttagtc aaaagagcag     1500

cctcattcaa catcagcgat ttcacactgg agaaaaacct tatgggtgtg aagaatgtgg     1560

gaaatctttt agttcagaag gacatcttag gagccatcaa cgagttcacg ccggagaaag     1620

acctttcaag tgtggagaat gtgtgaaatc tttcagtcat aagcgcagcc ttgttcacca     1680

tcagcgagtt cacagtggag aaagacctta tcagtgtgga gaatgtggga aatctttcag     1740

tcaaaagggc aacctcgttc tacaccagcg agttcacact ggagcaagac cttatgagtg     1800

tggagaatgt gggaaatcat ttagttcaaa aggacatctt aggaaccatc agcaaattca     1860

cactggggac agactttatg agtgtggaga gtgtgggaaa tcttttagtc ataaaggcac     1920

cctcattcta catcagcgag ttcaccctag agaaagatct tatgggtgtg gagaatgtgg     1980

gaaatctttt agttcaatcg ggcaccttag gagccatcag cgcgttcata ctggagagag     2040

gccttatgag tgtggagaat gtgggaaatc ttttagtcat aagcgcagcc ttgttcacca     2100

tcagcgcatg cacactggag aaagacctta caagtgtgga gactgtggga aatcttttaa     2160

tgaaaaagga caccttagga atcatcagcg agttcacact acagaaagac cttttaagtg     2220

tggggaatgt gggaaatgtt ttagtcacaa gggtaacctc attctacacc agcatggcca     2280

tactggagaa agaccttatg tatgtaggga atgtggaaaa ttatttaaga agaagtctca     2340

cctccttgta caccagagaa ttcacaatgg agaaaagcca tatgcttgtg aagcttgtca     2400

gaaatttttt agaaacaagt accaactcat tgcacatcag agagttcaca ctggagaaag     2460

gccttatgaa tgcaatgatt gtggaaaatc atttacccac agctctacat tctgtgttca     2520

taagcgaatt cacactggag aaaagcctta tgagtgcagt gaatgtggaa aatctttcgc     2580

tgaaagctcc agtttcacaa aacacaaaag agttcacact ggagaaaagc cttatgagtg     2640

cagtgaatgt ggaaaatctt ttgctgaaag ctccagtctc actaaacaca agagagttca     2700

cactggagaa aagccttata aatgtgagaa atgtgggaaa ttatttaaca agaagtctca     2760

cctccttgta caccagagtt cacactggag aaaagccata tgagtgtgag gattgtcaga     2820

aagtttttag caagaaggac cacctcattg cacaccagag agttcacact ggagaaaggc     2880

catatgaatg cagtgattgt gggaagtcat ctacccacag ctctgcattc tgtgttcata     2940

agagagttca cactggtcac accaccttat gagtgcagtg aatgtgggaa atcctttgct     3000

gaaactttca gtctcattaa acacaggaga gttcacactg gagtaaggtc ttgtgattgc     3060

agcaaatgtg ggaaaaaagt tacctgaagg tcttttctcc ttgaatatca gagagttcac     3120

actagacaaa taaaatacat ttgggcaatt ttgtagccac acctctttgc tccttcaaga     3180

tcagagttaa cactggatca gggccttacc agtgtgacat gtgagatatt tatgtagaaa     3240

tctagcttca taacacacag gagacttccc actgcagaaa tgccttttga atgtaatgaa     3300

tgcaagaaag ccttcagcct ttttattgga gcctcaaaca ttgacatgag aaaaacacca     3360

tagatgtata tggaatgtta tttctttttc aatgtaaccc tttgagagtg ccacctacct     3420

agattgaatg tcatttattg agcatctgca aaagttccaa gtgtgtggca gctacagtgc     3480

atttttcact atacccaggt accttgctag attttttttg agacaggttg tcactgtgtc     3540

gctcaggatg gcgtgcagtg gtgtgttcac atttcactgc acccttgatc tgggcttaag     3600

tgattctgtt gcctcggcct cctgagtagc tgaaaccaca ggcatgcact accatgctcc     3660

actaattttt ttaagttttg gagagacagg gtctcaccat gttgcccagg ctggtcttaa     3720

actcctggct caagcgatcc ttccaccttg gcctccaaac atgctgggat tacaggtgtg     3780

agttactgtg cctggccttt tttttttttt tttttaactt ttaatttctg atcgagtcac     3840

agaaggattt gttgagtagc ttcagcactt cttcctttgt catttttttc tgtctgataa     3900

gtcatgccat ggacgttacc catttttatc ccagaggcct cttacgttga cttgaaaaga     3960

cggactatgt ctttcagaga tcttgtgggt atcacatcaa tcttgacaaa ttttctaccc     4020

tccaagtcat gatcctaaga acagcttgcc tcccatttct ccggtttgtg ctattatgaa     4080

ggccttattg tttcagcctt cttcaatctt gagggttgtt gtcactgtat gggtggttca     4140

gaaataagta ggtcctgtta ctatgaaggg ggtcacagct tttgttggca tagctaaact     4200

ttgtggctca tggaacagta tgaatgcaga atgtagcttt ctccacttgt ggactgcttt     4260

gcatagctgc cagaggcctc cagagaagac cttcagggct ttgtggtctt tatctgtagc     4320

acggatacta aaatttgtgg gttcataggt cagctggata cagggcattt tttgtgacaa     4380

tttctggcat tttttgaaca agacaaaatt cttttacgag gtatattgca ttgtacttgg     4440

tacggctgag ggaagtctgt tgcccagctc ttgcaatgca gacacatgcc ctgatatcca     4500

gaattctgta ggataacatc acagattgta atgctatcag gtgaaattat aattttatag     4560

aattacttta tttataggca gtggaggaga cagaataatg taactgcaac tcatgtcttt     4620

tttttctttt tttttctttt tttttgaggc agagcctcac cctgttgccc aggctggagt     4680

gcagtggcat aatcttggct cacggcaacc tctgcctccc aggttcaaac gattctcctg     4740

cctcagcctc ctgagtagct gggactacag gcacatgcca ccacacccag ctaatttttg     4800

tatttttagt agagatgggg tttcaccatg ttggccaggc tggtctcgaa ctcctgacct     4860

tgtgatctgc tggcctcagc ctcccaaagt cctgggatta caggtgagcc accacgtgca     4920

gcgtaatgca tgtcttttaa aagggcatcc acaatgatcc agtcactacg tatatgatga     4980

atatgcagat acaggaatta tcaggacttc cataatgatg aatattgtat tgttgaggcc     5040

attgtcagag gaaataatct aaaggttttg tgaattcctg tactcattct gggctgttct     5100

cctcaaggtc attcctgcat taacaggagg aagatgatag ggagaaggga gatctcagtt     5160

cagtgatgtg gcctttgtga ccagccagcc acttaatcag gtggaaatgg ccttagtgcc     5220

acatcaatat ttgctaccgt ggaggctagt tttcccactt agggcatgag aagaattggt     5280

gtagtcagta tagagttgcc aaacctgttt tccaaaaata atggtaaatc tatatttttc     5340

ttttgaactg cattttttta attattatta ttatttattt tgagacggag tcttgctctg     5400

ttgcccaggc tggatggagt gcagtggcac gatctcggct cactgcaagc tctgcctcct     5460

gggttcacac cattcttctg cctcagcctc ccaagtagct gggactacag gtgcccgcca     5520

ccatacccag ctaatttttt gtatctttac tagagatggg gtttcaccat gttaactagg     5580

atggtctcga tctcctgacc tcgtgatccg cctgccttgg cctcccaaag tgctgggatt     5640

ataggcatga gccaccgtgc ccaacctttt tttttttttt ttgagacaga gtctcactgt     5700

cagccaggct ggagtgcagt ggcatgacct tggctcattg caacctctac ctcctaggtt     5760

caagcaattc tcctggctca gcctcccatg taggtgggac tggaagcatg tgccaccatg     5820

cccggccaag ttttgtattt ttagtagaga cggagttttg ccatgttggc caggctgatc     5880

ttggactcct gacctcaggt gatatgcctg cctcagcctc ccagagtggt gggaatacag     5940

gtgtgagcca ctgctgccag tctgaagtat attttaaagc tgtgatgagt tataaatgac     6000

attcagtaag ctatgcatat ttaagctgta gcatgtgata aatcttgagt ttcatataat     6060

cccatgaaac cattaacata gtcacaataa tgaacttaac acctttatat ttacttggaa     6120

cctttttata aaggctttct ttctgttctc cagacaacca atgatttact ttgctgtaca     6180

gtagagtact ttccattttc tggaatgtta gatgagtgat gtaataaagt gtttcctctt     6240

ataa                                                                  6244


<210>  14
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ala Ala Ala Thr Leu Arg Leu Ser Ala Gln Gly Thr Val Thr 
1               5                   10                  15      


Phe Glu Asp Val Ala Val Asn Phe Thr Trp Glu Glu Trp Asn Leu Leu 
            20                  25                  30          


Ser Glu Ala Gln Arg Cys Leu Tyr Arg Asp Val Thr Leu Glu Asn Leu 
        35                  40                  45              


Ala Leu Ile Ser Ser Leu Gly Cys Trp Cys Gly Val Glu Asp Glu Ala 
    50                  55                  60                  


Ala Pro Ser Lys Gln Ser Ile Tyr Ile Gln Arg Glu Thr Gln Val Arg 
65                  70                  75                  80  


Thr Pro Met Ala Gly Val Ser Pro Lys Lys Ala His Pro Cys Glu Met 
                85                  90                  95      


Cys Gly Pro Ile Leu Gly Asp Ile Leu His Val Ala Asp His Gln Gly 
            100                 105                 110         


Thr His His Lys Gln Lys Leu His Arg Cys Glu Ala Trp Gly Asn Lys 
        115                 120                 125             


Leu Tyr Asp Ser Gly Asn Phe His Gln His Gln Asn Glu His Ile Gly 
    130                 135                 140                 


Glu Lys Pro Tyr Arg Gly Ser Val Glu Glu Ala Leu Phe Ala Lys Arg 
145                 150                 155                 160 


Cys Lys Leu His Val Ser Gly Glu Ser Ser Val Phe Ser Glu Ser Gly 
                165                 170                 175     


Lys Asp Phe Leu Pro Arg Ser Gly Leu Leu Gln Gln Glu Ala Ser His 
            180                 185                 190         


Thr Gly Glu Lys Ser Asn Ser Lys Thr Glu Cys Val Ser Pro Ile Gln 
        195                 200                 205             


Cys Gly Gly Ala His Tyr Ser Cys Gly Glu Ser Met Lys His Phe Ser 
    210                 215                 220                 


Thr Lys His Ile Leu Ser Gln His Gln Arg Leu Leu Thr Arg Glu Glu 
225                 230                 235                 240 


Cys Tyr Val Cys Cys Glu Cys Gly Lys Ser Phe Ser Lys Tyr Ala Ser 
                245                 250                 255     


Leu Ser Asn His Gln Arg Val His Thr Glu Lys Lys His Glu Cys Gly 
            260                 265                 270         


Glu Cys Gly Lys Ser Phe Ser Lys Tyr Val Ser Phe Ser Asn His Gln 
        275                 280                 285             


Arg Val His Thr Glu Lys Lys His Glu Cys Gly Glu Cys Gly Lys Ser 
    290                 295                 300                 


Phe Ser Lys Tyr Val Ser Phe Ser Asn His Gln Arg Val His Thr Gly 
305                 310                 315                 320 


Lys Arg Pro Tyr Glu Cys Gly Glu Cys Gly Lys Ser Phe Ser Lys Tyr 
                325                 330                 335     


Ala Ser Phe Ser Asn His Gln Arg Val His Thr Glu Lys Lys His Tyr 
            340                 345                 350         


Glu Cys Gly Glu Cys Gly Lys Ser Phe Ser Lys Tyr Val Ser Phe Ser 
        355                 360                 365             


Asn His Gln Arg Val His Thr Gly Lys Arg Pro Tyr Glu Cys Gly Glu 
    370                 375                 380                 


Cys Gly Lys Ser Phe Ser Lys Tyr Ala Ser Phe Ser Asn His Gln Arg 
385                 390                 395                 400 


Val His Thr Asp Lys Lys His Tyr Glu Cys Gly Glu Cys Gly Lys Ser 
                405                 410                 415     


Phe Ser Gln Lys Ser Ser Leu Ile Gln His Gln Arg Phe His Thr Gly 
            420                 425                 430         


Glu Lys Pro Tyr Gly Cys Glu Glu Cys Gly Lys Ser Phe Ser Ser Glu 
        435                 440                 445             


Gly His Leu Arg Ser His Gln Arg Val His Ala Gly Glu Arg Pro Phe 
    450                 455                 460                 


Lys Cys Gly Glu Cys Val Lys Ser Phe Ser His Lys Arg Ser Leu Val 
465                 470                 475                 480 


His His Gln Arg Val His Ser Gly Glu Arg Pro Tyr Gln Cys Gly Glu 
                485                 490                 495     


Cys Gly Lys Ser Phe Ser Gln Lys Gly Asn Leu Val Leu His Gln Arg 
            500                 505                 510         


Val His Thr Gly Ala Arg Pro Tyr Glu Cys Gly Glu Cys Gly Lys Ser 
        515                 520                 525             


Phe Ser Ser Lys Gly His Leu Arg Asn His Gln Gln Ile His Thr Gly 
    530                 535                 540                 


Asp Arg Leu Tyr Glu Cys Gly Glu Cys Gly Lys Ser Phe Ser His Lys 
545                 550                 555                 560 


Gly Thr Leu Ile Leu His Gln Arg Val His Pro Arg Glu Arg Ser Tyr 
                565                 570                 575     


Gly Cys Gly Glu Cys Gly Lys Ser Phe Ser Ser Ile Gly His Leu Arg 
            580                 585                 590         


Ser His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Glu Cys Gly Glu 
        595                 600                 605             


Cys Gly Lys Ser Phe Ser His Lys Arg Ser Leu Val His His Gln Arg 
    610                 615                 620                 


Met His Thr Gly Glu Arg Pro Tyr Lys Cys Gly Asp Cys Gly Lys Ser 
625                 630                 635                 640 


Phe Asn Glu Lys Gly His Leu Arg Asn His Gln Arg Val His Thr Thr 
                645                 650                 655     


Glu Arg Pro Phe Lys Cys Gly Glu Cys Gly Lys Cys Phe Ser His Lys 
            660                 665                 670         


Gly Asn Leu Ile Leu His Gln His Gly His Thr Gly Glu Arg Pro Tyr 
        675                 680                 685             


Val Cys Arg Glu Cys Gly Lys Leu Phe Lys Lys Lys Ser His Leu Leu 
    690                 695                 700                 


Val His Gln Arg Ile His Asn Gly Glu Lys Pro Tyr Ala Cys Glu Ala 
705                 710                 715                 720 


Cys Gln Lys Phe Phe Arg Asn Lys Tyr Gln Leu Ile Ala His Gln Arg 
                725                 730                 735     


Val His Thr Gly Glu Arg Pro Tyr Glu Cys Asn Asp Cys Gly Lys Ser 
            740                 745                 750         


Phe Thr His Ser Ser Thr Phe Cys Val His Lys Arg Ile His Thr Gly 
        755                 760                 765             


Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ser Phe Ala Glu Ser 
    770                 775                 780                 


Ser Ser Phe Thr Lys His Lys Arg Val His Thr Gly Glu Lys Pro Tyr 
785                 790                 795                 800 


Glu Cys Ser Glu Cys Gly Lys Ser Phe Ala Glu Ser Ser Ser Leu Thr 
                805                 810                 815     


Lys His Lys Arg Val His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys 
            820                 825                 830         


Cys Gly Lys Leu Phe Asn Lys Lys Ser His Leu Leu Val His Gln Ser 
        835                 840                 845             


Ser His Trp Arg Lys Ala Ile 
    850                 855 


<210>  15
<211>  4685
<212>  DNA
<213>  Homo sapiens

<400>  15
agtagcggct gtgtatcggt gacgcgggtg tttccccagt ttgtggcccc tgagtgctgg       60

ggggggaccg cggtgactga acctagaagg tggagaggaa tcgtcctcgg tgcccagagg      120

cggctctgca gccccgtgac ggcgaccact gctcccgggc cgtgcttccc caagtagtcc      180

gatggcagcg gctgcgccga ggcgcccgac tcagcagggc actgtgacct ttgaagatgt      240

ggctgtgaac ttttcccagg aggagtggtg tcttcttagt gaggctcaga ggtgcttgta      300

ccgtgatgtg atgctagaga acctggctct catatcctcg ctgggttgtt ggtgtggatc      360

aaaagatgag gaggcacctt gtaagcagag aatttctgta caaagagagt ctcagagcag      420

gactcctagg gcaggtgttt ctcctaagaa ggctcacccc tgtgaaatgt gtggcctcat      480

cttggaggat gtttttcact ttgctgacca ccaggaaact catcacaagc agaagctgaa      540

caggagtgga gcatgtggaa aaaacttgga tgacactgca taccttcatc agcaccagaa      600

gcagcatatt ggagagaaat tctacagaaa gagtgtcaga gaagcatcgt ttgtaaagaa      660

acgtaagctc agggtgtcac aggagccatt tgtcttccgc gagtttggga aggacgttct      720

gcccagttca ggattgtgcc aagaagcagc tgctgtagag aagacagaca gtgaaactat      780

gcatggccca ccctttcagg agggaaaaac taattacagt tgtggaaaac gcacaaaagc      840

cttcagcacc aaacactcag ttattccaca ccagaaactt ttcactagag atggatgtta      900

tgtgtgcagt gattgtggaa aatcctttag cagatatgtc agcttcagta atcatcagcg      960

agatcacact gcaaaaggac cttatgattg tggagagtgt gggaaatctt atagtcgaaa     1020

gagcagcctt attcaacatc agcgagtcca cactggaaag acagcttatc cctgtgagga     1080

gtgcgggaaa tcttttagtc agaagggcag ccttattagc catcagcgtg ttcacactgg     1140

agaaaggcct tatgagtgta gagaatatgg gaaatctttt ggtcaaaagg gtaacctcat     1200

tcaacatcag caaggtcaca ctggagagag agcttatcac tgtggggaat gtgggaaatc     1260

ttttcgtcag aagttctgct ttattaacca tcagcgtgtt cacactggag aaaggcctta     1320

caagtgtgga gaatgtggaa aatcttttgg tcaaaagggc aacctcgttc aacatcagcg     1380

aggtcatact ggagaaaggc cctatgagtg caaggaatgt gggaaatcat ttaggtacag     1440

atcccacctc actgaacacc agagacttca cactggggaa agaccttaca attgtaggga     1500

atgtgggaaa ttatttaaca ggaagtatca tcttctcgtt catgagagag ttcacactgg     1560

agaaaggcca tatgcgtgtg aggtatgtgg gaaattattt ggtaataaga actgcgtgac     1620

tatacatcag aggattcaca ctggagaaag gccgtatgaa tgcaatgaat gtgggaaatc     1680

atttctttcc agctctgcgc ttcatgttca taaaagagtt cattctggac aaaagcctta     1740

taagtgcagt gaatgtggaa aatcctttgc tgaatgttcc agtctcatta aacacaggag     1800

aattcacact ggagaaaggc cttatgaatg taccaaatgt ggaaaaacat ttcagcgaag     1860

ctctaccctc cttcatcatc agagttcaca caggagaaag gccttatgag tgcagtgaat     1920

atgggaaatc gtttgctgaa acatcccgtc tcattaaaca caggagagtt catactggag     1980

aaaggcctta tgagtgctgt caatctggga aacatcagaa tgtctgctct ccttggtctt     2040

aagagacttc gcattggaac ggagtctcat tctgtcaccc aggctggagt gcagtggtgc     2100

aatcttggct cactgcaact tgggcctccc aggttcaagt gattctccta cctcagcctc     2160

ccaaggagct gagattacga gtacaccaca ccatgcccgg ccaaatactt ggttttcagt     2220

accacaagag ctatgagctg gttatccact tcatgtggaa tcataagtgt ccccaagtga     2280

caatacgtat agattgctgg gcagtgaaac agttaagatg tcaccgtagc ttgctttcta     2340

ttcaacatct ttctaagatt accttactat ttcttttgtt ccaagtttgt atttcctcag     2400

agttctcaca tatggaaagg atacacactt tgtagaaaca agaactttat gttatccaag     2460

ttctgggata gccatgagct ccaattacct cagagctccg agtcctctac tcagtacccg     2520

ttgagattta tgtgttctga ggcttttgtc ttctagctac ttacttcatt ctccatgggt     2580

aacgtcattc atccacatta actaatttcc tcactccaag ctcttttctg gagataatct     2640

ccagtccctg tgcagacact gtcattgcac tttctgctga aatggtagtt tcttgccagc     2700

aaggtgagat tatggaatcc agaatctttt ttcaggggcc acatgcccat ttccccactt     2760

gcatgaatgt cgacactgta gccacagttt tggccgtaaa tgtgaatttg gcaagtaacc     2820

actgttccca aattgggaaa tgtcccagtc agaagaagat tatctgggac actgatactg     2880

acagggagat gggacattct gagggacccg gaggcaggga gccacctcct cagcttccct     2940

gagggctgcc tagaatctct cttgtttcct ctcactctga attattcttc ctctcatgac     3000

tgaccaaaca catggaacct cacaaagtcc attttaagag ctttatcttg tgaagtgaag     3060

aacatgaaga tagtttgaat caaagttatt gagtggacac ttaatgtctt tataacattt     3120

tttacatatg tgtttgtgtt ttttggggag cataatttgc aaatggaata tctgttattt     3180

tactaagatg cttcatggat acaagagtta aaacttcctg tcccatttag tgaaacaaaa     3240

ggttaagaaa tgtggataaa gcttgtaagt tagaaatggc aagataatca gctatatgaa     3300

gaatctcagc tgggtgtttt ggctcaggcc tgtaatccca gcactttggg aggctgaggt     3360

gggtggctta caaggtcagg agttcaagac caccctggac aatatggtga aaccctgtct     3420

ctactaaaaa tacaaaaatt acccaagcat agtggtgggt gcctgtagtc ccagctgctt     3480

gggaggctga ggcaggagaa ttcgttaaac ctgggaggca taggttgcag tgagccgaga     3540

ttgcaccact gcactccagc ctggtgacag agcgagactc cgtctcaaaa aaaaaaaaaa     3600

aaaaaaaaaa aaatctcaat ccctaaatgt taccttttat aacagcaggt tatatgggct     3660

tagatattat ccctaaattt tttttttttt ttttttttga gacagagtct cactctgtca     3720

cccaggctga agtgcaatgg catggtctcg gctcactgca acctccgcct cccaggttca     3780

agtgattctc ttgcctcagc ctcccaagta gctgggccta taggttccct ccaccacgcc     3840

cacctaattt ttgtattttt agtagagatg ggctttcact acgttagcca ggctggtctc     3900

aaacttgtga cctcatgatc cacccccctc agcctcctaa agtgctggga ttacaggcat     3960

ctgccacggc actcggctta tccctagaaa tcctatgata gcatgatgta taggcaccta     4020

aaggcatggc acttgagaaa tgtgaataag attgtaagtt acaaatagca aggtacagtc     4080

agatgttaac agtctcagcc cctaaatgtc accttgtatt acagcatgtt atataagcac     4140

atacaggcac atacatgaaa tagtgatact tcattctcag taatattttt catccttctc     4200

actggaaaga tctttgatga tttttaatca acataggagt ttcaatgata tctagaagtt     4260

taaaagggct cgttcaaaca aattatgacc atacaccctg aagagtatgt gtctgtctct     4320

tgtggtgtaa atttttattt tattacaccc aattatgttc ccacaaaacc tttataattg     4380

ggaaattaag gagccttcct cggaaatgga ggttgcaatc agctgagatg gtaccactgc     4440

actctagcct gggcaaaaga gcaaggccct gcctcaaaaa aaacaaaact tttttcttca     4500

taaactacag tttatatagg caaaactttc agtactaagc aattttagtc tctgcaggct     4560

cttgtcttga attaatacaa cttttgttaa ttctcttatg aagttaaatc ttcctgcttg     4620

tatgcaactt atatgttgaa atttttttgt acaaaagatt catacatctt tcctgtttga     4680

aatta                                                                 4685


<210>  16
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ala Ala Ala Pro Arg Arg Pro Thr Gln Gln Gly Thr Val Thr 
1               5                   10                  15      


Phe Glu Asp Val Ala Val Asn Phe Ser Gln Glu Glu Trp Cys Leu Leu 
            20                  25                  30          


Ser Glu Ala Gln Arg Cys Leu Tyr Arg Asp Val Met Leu Glu Asn Leu 
        35                  40                  45              


Ala Leu Ile Ser Ser Leu Gly Cys Trp Cys Gly Ser Lys Asp Glu Glu 
    50                  55                  60                  


Ala Pro Cys Lys Gln Arg Ile Ser Val Gln Arg Glu Ser Gln Ser Arg 
65                  70                  75                  80  


Thr Pro Arg Ala Gly Val Ser Pro Lys Lys Ala His Pro Cys Glu Met 
                85                  90                  95      


Cys Gly Leu Ile Leu Glu Asp Val Phe His Phe Ala Asp His Gln Glu 
            100                 105                 110         


Thr His His Lys Gln Lys Leu Asn Arg Ser Gly Ala Cys Gly Lys Asn 
        115                 120                 125             


Leu Asp Asp Thr Ala Tyr Leu His Gln His Gln Lys Gln His Ile Gly 
    130                 135                 140                 


Glu Lys Phe Tyr Arg Lys Ser Val Arg Glu Ala Ser Phe Val Lys Lys 
145                 150                 155                 160 


Arg Lys Leu Arg Val Ser Gln Glu Pro Phe Val Phe Arg Glu Phe Gly 
                165                 170                 175     


Lys Asp Val Leu Pro Ser Ser Gly Leu Cys Gln Glu Ala Ala Ala Val 
            180                 185                 190         


Glu Lys Thr Asp Ser Glu Thr Met His Gly Pro Pro Phe Gln Glu Gly 
        195                 200                 205             


Lys Thr Asn Tyr Ser Cys Gly Lys Arg Thr Lys Ala Phe Ser Thr Lys 
    210                 215                 220                 


His Ser Val Ile Pro His Gln Lys Leu Phe Thr Arg Asp Gly Cys Tyr 
225                 230                 235                 240 


Val Cys Ser Asp Cys Gly Lys Ser Phe Ser Arg Tyr Val Ser Phe Ser 
                245                 250                 255     


Asn His Gln Arg Asp His Thr Ala Lys Gly Pro Tyr Asp Cys Gly Glu 
            260                 265                 270         


Cys Gly Lys Ser Tyr Ser Arg Lys Ser Ser Leu Ile Gln His Gln Arg 
        275                 280                 285             


Val His Thr Gly Lys Thr Ala Tyr Pro Cys Glu Glu Cys Gly Lys Ser 
    290                 295                 300                 


Phe Ser Gln Lys Gly Ser Leu Ile Ser His Gln Arg Val His Thr Gly 
305                 310                 315                 320 


Glu Arg Pro Tyr Glu Cys Arg Glu Tyr Gly Lys Ser Phe Gly Gln Lys 
                325                 330                 335     


Gly Asn Leu Ile Gln His Gln Gln Gly His Thr Gly Glu Arg Ala Tyr 
            340                 345                 350         


His Cys Gly Glu Cys Gly Lys Ser Phe Arg Gln Lys Phe Cys Phe Ile 
        355                 360                 365             


Asn His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Lys Cys Gly Glu 
    370                 375                 380                 


Cys Gly Lys Ser Phe Gly Gln Lys Gly Asn Leu Val Gln His Gln Arg 
385                 390                 395                 400 


Gly His Thr Gly Glu Arg Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ser 
                405                 410                 415     


Phe Arg Tyr Arg Ser His Leu Thr Glu His Gln Arg Leu His Thr Gly 
            420                 425                 430         


Glu Arg Pro Tyr Asn Cys Arg Glu Cys Gly Lys Leu Phe Asn Arg Lys 
        435                 440                 445             


Tyr His Leu Leu Val His Glu Arg Val His Thr Gly Glu Arg Pro Tyr 
    450                 455                 460                 


Ala Cys Glu Val Cys Gly Lys Leu Phe Gly Asn Lys Asn Cys Val Thr 
465                 470                 475                 480 


Ile His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Asn Glu 
                485                 490                 495     


Cys Gly Lys Ser Phe Leu Ser Ser Ser Ala Leu His Val His Lys Arg 
            500                 505                 510         


Val His Ser Gly Gln Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys Ser 
        515                 520                 525             


Phe Ala Glu Cys Ser Ser Leu Ile Lys His Arg Arg Ile His Thr Gly 
    530                 535                 540                 


Glu Arg Pro Tyr Glu Cys Thr Lys Cys Gly Lys Thr Phe Gln Arg Ser 
545                 550                 555                 560 


Ser Thr Leu Leu His His Gln Ser Ser His Arg Arg Lys Ala Leu 
                565                 570                 575 


<210>  17
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  17
gcttatacat ctagtctcat t                                                 21


<210>  18
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  18
ccgggcttat acatctagtc tcattctcga gaatgagact agatgtataa gcttttt          57


<210>  19
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  19
gcagcaaata tgggaaatta t                                                 21


<210>  20
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  20
ccgggcagca aatatgggaa attatctcga gataatttcc catatttgct gcttttt          57


<210>  21
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  21
gccaaagcta tgacctcttt a                                                 21


<210>  22
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  22
ccgggccaaa gctatgacct ctttactcga gtaaagaggt catagctttg gcttttt          57


<210>  23
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  23
agtcgaaaga gcagccttat t                                                 21


<210>  24
<211>  62
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  24
ccggagtcga aagagcagcc ttattctcga gaataaggct gctctttcga ctttttttga       60

at                                                                      62


<210>  25
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  25
gcagcatatt ggagagaaat t                                                 21


<210>  26
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  26
ccgggcagca tattggagag aaattctcga gaatttctct ccaatatgct gcttttt          57


<210>  27
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  27
cgggaagaat gggagcttct t                                                 21


<210>  28
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  28
ccggcgggaa gaatgggagc ttcttctcga gaagaagctc ccattcttcc cgttttt          57


<210>  29
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  29
cgggagaaag acatcatgaa t                                                 21


<210>  30
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  30
ccggcgggag aaagacatca tgaatctcga gattcatgat gtctttctcc cgttttt          57


<210>  31
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  31
tatgtcacat gagccattta t                                                 21


<210>  32
<211>  58
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  32
ccggtatgtc acatgagcca tttatctcga gataaatggc tcatgtgaca tatttttg         58


<210>  33
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  33
gcagatcatc agggaacaca t                                                 21


<210>  34
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  34
ccgggcagat catcagggaa cacatctcga gatgtgttcc ctgatgatct gcttttt          57


<210>  35
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  35
gctctacatt ccgtgttcat a                                                 21


<210>  36
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  36
ccgggctcta cattccgtgt tcatactcga gtatgaacac ggaatgtaga gcttttt          57


<210>  37
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  37
ccttctaagc agagtattta t                                                 21


<210>  38
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  38
ccggccttct aagcagagta tttatctcga gataaatact ctgcttagaa ggttttt          57


<210>  39
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  39
cagcaccaga atgagcacat t                                                 21


<210>  40
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  40
ccggcagcac cagaatgagc acattctcga gaatgtgctc attctggtgc tgttttt          57


<210>  41
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  41
gcagatcatc agggaacaca t                                                 21


<210>  42
<211>  57
<212>  DNA
<213>  Unknown

<220>
<223>  synthetic sequence

<400>  42
ccgggcagat catcagggaa cacatctcga gatgtgttcc ctgatgatct gcttttt          57


