﻿                         序列表

<110>  江苏恒瑞医药股份有限公司
       上海恒瑞医药有限公司

<120>  一种抗原结合分子

<130> 722049CPCT

<150>  CN202110527339.7
<151>  2021-05-14

<160>  181

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  330
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  IgG1重链恒定区序列


<400>  1
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  2
<211>  330
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  knob-IgG1重链恒定区序列


<400>  2
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu 
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  3
<211>  330
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  hole -IgG1重链恒定区序列


<400>  3
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210>  4
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  kappa轻链恒定区序列


<400>  4
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210>  5
<211>  106
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  lambda轻链恒定区序列


<400>  5
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     

<210>  6
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  F0抗体VH序列


<400>  6
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Thr 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Ser 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Ala Arg Leu Tyr Ala Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Ala Leu Val Thr Val Ser Ser 
        115                 

<210>  7
<211>  110
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  F0抗体VL 序列


<400>  7
Asp Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Ser 
            20                  25                  30          
His Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Met 
        35                  40                  45              
Leu Ile Tyr Asn Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Ile His Val Asp Arg 
                85                  90                  95      
Asp Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 

<210>  8
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  N0抗体VH序列


<400>  8
Asp Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Ser Ser Leu Ser 
            20                  25                  30          
Trp Met Ser Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Asn Tyr Val Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Leu Trp Thr Phe Asp Ser Trp Gly Gln Gly Thr Leu Leu 
            100                 105                 110         
Thr Val Ser Pro 
        115     

<210>  9
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  N0抗体 VL序列


<400>  9
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Asn Arg 
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Ala Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Ala Glu Asp Phe Ala Met Tyr His Cys Gln Gln Tyr Gly Ser Phe Pro 
                85                  90                  95      
Arg Thr Phe Gly Gln Gly Thr Met Val Asp Ile Lys 
            100                 105             

<210>  10
<211>  120
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  S0抗体VH序列


<400>  10
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Val Phe Ser Ser Tyr 
            20                  25                  30          
Asp Met Ser Trp Val Arg Gln Thr Pro Glu Arg Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Ser Gly Gly Gly Ile Thr Tyr Ala Pro Ser Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala His Tyr Phe Gly Ser Ser Gly Pro Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210>  11
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  S0抗体VL序列


<400>  11
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Phe Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              
Tyr Asn Thr Arg Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Phe 
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  12
<211>  121
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  V0抗体VH序列


<400>  12
Gln Val Gln Leu Gln Gln Ser Ala Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          
Thr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Tyr Ile Asn Pro Asn Ser Arg Asn Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Glu Thr Thr Leu Thr Ala Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Ser Gly Ser Thr Pro Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         
Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210>  13
<211>  106
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  V0抗体VL序列


<400>  13
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Val Ser 
    50                  55                  60                  
Val Ser Gly Thr Ser His Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     

<210>  14
<211>  120
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  J0抗体VH序列


<400>  14
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly His Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Glu Ile Tyr Tyr Tyr Ala Phe Asp Ser Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210>  15
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  J0抗体VL序列


<400>  15
Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Gly Asp Asn Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Ala Asp Trp Val Asp Phe Tyr 
                85                  90                  95      
Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         

<210>  16
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  H0抗体 VH序列


<400>  16
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          
Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Thr Ser Ile Ser Tyr Glu Gly Asp Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gln Thr Leu Arg Glu Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  17
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  H0抗体VL序列


<400>  17
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Asn Tyr 
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Thr Ser Asn Leu Glu Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Lys Glu Phe Pro Arg 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  18
<211>  116
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  R0抗体VH序列


<400>  18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Ser Leu Thr Ser Asn 
            20                  25                  30          
Ser Val Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Leu Ile Trp Ser Asn Gly Asp Thr Asp Tyr Asn Ser Ala Ile Lys 
    50                  55                  60                  
Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Glu Tyr Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210>  19
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  R0抗体VL序列


<400>  19
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Ala Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Lys Phe Pro Asn 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105         

<210>  20
<211>  123
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  B0抗体VH序列


<400>  20
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
            20                  25                  30          
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  
Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
            100                 105                 110         
Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
        115                 120             

<210>  21
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  B0抗体VL序列


<400>  21
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      
Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      
Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 
            100                 105             

<210>  22
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  U0抗体VH序列


<400>  22
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          
Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210>  23
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  U0抗体VL序列


<400>  23
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  24
<211>  122
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  D0抗体VH序列


<400>  24
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe Asp Pro Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210>  25
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  D0抗体VL序列


<400>  25
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Arg 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210>  26
<211>  121
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  I0抗体VH序列


<400>  26
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Gly Tyr 
            20                  25                  30          
Asp Leu Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ile Ile Trp Gly Asp Gly Thr Thr Asp Tyr Asn Ser Ala Val Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Gly Tyr Trp Tyr Ala Thr Ser Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210>  27
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  I0抗体VL序列


<400>  27
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Phe His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Glu His Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  28
<211>  117
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  C0抗体VH序列


<400>  28
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
His Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Asp Ile Asn Pro Asp Ile Gly Gly Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Asp Phe Asp Ser Phe Ala Asn Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  29
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  C0抗体VL序列


<400>  29
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Ser Ile Ile 
            20                  25                  30          
Gly Thr Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr His Ala Ser Asn Leu Glu Thr Gly Val Pro Asp 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      
Lys Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     

<210>  30
<211>  104
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  IL6Ra.0链序列


<400>  30
Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val Thr Ala Val 
1               5                   10                  15      
Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp Pro His Ser 
            20                  25                  30          
Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg Tyr Arg Ala 
        35                  40                  45              
Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp Leu Gln His 
    50                  55                  60                  
His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His Val Val Gln 
65                  70                  75                  80  
Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser Glu Trp Ser 
                85                  90                  95      
Pro Glu Ala Met Gly Thr Pro Trp 
            100                 

<210>  31
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  IL6Rb.0链序列


<400>  31
Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro Pro His Asn Leu Ser 
1               5                   10                  15      
Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu Thr Trp Thr 
            20                  25                  30          
Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys Tyr Asn Ile Gln Tyr 
        35                  40                  45              
Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile Pro Pro Glu Asp Thr 
    50                  55                  60                  
Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp Leu Lys Pro Phe Thr 
65                  70                  75                  80  
Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu Asp Gly Lys Gly Tyr 
                85                  90                  95      
Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile Thr 
            100                 105             

<210>  32
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.0链序列


<400>  32
Gly Ile Pro Pro Lys Ile Glu Ala Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Cys Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Cys Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Met Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Ser Leu 
65                  70                  75                  80  
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  33
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.0链序列


<400>  33
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Cys Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Thr Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Cys Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Ala Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  34
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  OL.0链序列


<400>  34
Gln Gly Ser Pro Pro Cys Phe Leu Arg Phe Pro Arg Pro Val Arg Val 
1               5                   10                  15      
Val Ser Gly Ala Glu Ala Glu Leu Lys Cys Val Val Leu Gly Glu Pro 
            20                  25                  30          
Pro Pro Val Val Val Trp Glu Lys Gly Gly Gln Gln Leu Ala Ala Ser 
        35                  40                  45              
Glu Arg Leu Ser Phe Pro Ala Asp Gly Ala Glu His Gly Leu Leu Leu 
    50                  55                  60                  
Thr Ala Ala Leu Pro Thr Asp Ala Gly Val Tyr Val Cys Arg Ala Arg 
65                  70                  75                  80  
Asn Ala Ala Gly Glu Ala Tyr Ala Ala Ala Ala Val Thr Val Leu Glu 
                85                  90                  95      
Pro Pro 
        

<210>  35
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.1链序列


<400>  35
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Met Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Ser Leu 
65                  70                  75                  80  
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  36
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.2链序列


<400>  36
Gly Ile Pro Pro Lys Ile Glu Ala Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Cys Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Met Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Ser Leu 
65                  70                  75                  80  
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  37
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.3链序列


<400>  37
Gly Ile Pro Pro Lys Ile Glu Ala Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Cys Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Met Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Ser Leu 
65                  70                  75                  80  
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  38
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.4链序列


<400>  38
Gly Ile Pro Pro Lys Ile Glu Ala Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Cys Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Met Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Ser Leu 
65                  70                  75                  80  
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  39
<211>  103
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.5链序列


<400>  39
Lys Ala Gly Ile Arg Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser 
1               5                   10                  15      
Asp Ile Ser Ile Asp Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe 
            20                  25                  30          
Thr Gly Glu Pro Thr Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys 
        35                  40                  45              
Ile His Ser Gln Glu Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp 
    50                  55                  60                  
Leu Thr Thr Leu Ile Ile Met Asp Val Gln Lys Gln Asp Gly Gly Leu 
65                  70                  75                  80  
Tyr Thr Leu Ser Leu Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val 
                85                  90                  95      
Asn Ile His Ile Arg Ser Ile 
            100             

<210>  40
<211>  103
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.1-L1链序列


<400>  40
Gly Gly Gly Gly Ser Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser 
1               5                   10                  15      
Asp Ile Ser Ile Asp Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe 
            20                  25                  30          
Thr Gly Glu Pro Thr Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys 
        35                  40                  45              
Ile His Ser Gln Glu Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp 
    50                  55                  60                  
Leu Thr Thr Leu Ile Ile Met Asp Val Gln Lys Gln Asp Gly Gly Leu 
65                  70                  75                  80  
Tyr Thr Leu Ser Leu Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val 
                85                  90                  95      
Asn Ile His Ile Arg Ser Ile 
            100             

<210>  41
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.1-L2链序列


<400>  41
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Pro Pro Lys Ile 
1               5                   10                  15      
Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp Glu Gly Lys Val Leu Thr 
            20                  25                  30          
Val Ala Ser Ala Phe Thr Gly Glu Pro Thr Pro Glu Val Thr Trp Ser 
        35                  40                  45              
Thr Gly Gly Arg Lys Ile His Ser Gln Glu Gln Gly Arg Phe His Ile 
    50                  55                  60                  
Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile Ile Met Asp Val Gln Lys 
65                  70                  75                  80  
Gln Asp Gly Gly Leu Tyr Thr Leu Ser Leu Gly Asn Glu Phe Gly Ser 
                85                  90                  95      
Asp Ser Ala Thr Val Asn Ile His Ile Arg Ser Ile 
            100                 105             

<210>  42
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.1链序列


<400>  42
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Cys Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Thr Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Cys Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  43
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.2链序列


<400>  43
Ser Gly Cys Pro Arg Phe Leu Thr Arg Pro Lys Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Cys Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Thr Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Cys Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Ala Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  44
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.3链序列


<400>  44
Ser Gly Ala Pro Arg Phe Leu Thr Cys Pro Lys Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Cys Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Thr Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Cys Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Ala Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  45
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.4链序列


<400>  45
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Thr Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  46
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.5链序列


<400>  46
Ser Gly Cys Pro Arg Phe Leu Thr Arg Pro Lys Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Thr Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Ala Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  47
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.6链序列


<400>  47
Ser Gly Ala Pro Arg Phe Leu Thr Cys Pro Lys Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Thr Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Ala Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  48
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.7链序列


<400>  48
Ser Gly Ala Pro Arg Phe Lys Thr Arg Pro Lys Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  49
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.8链序列


<400>  49
Ser Gly Ala Pro Arg Phe Lys Thr Arg Pro Lys Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu His Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  50
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.9链序列


<400>  50
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  51
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.10链序列


<400>  51
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu His Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  52
<211>  102
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.11链序列


<400>  52
Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys 
1               5                   10                  15      
Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile 
            20                  25                  30          
Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro 
        35                  40                  45              
Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr 
    50                  55                  60                  
Arg Leu Thr Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val 
65                  70                  75                  80  
Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu 
                85                  90                  95      
Gln Val Asp Ala Glu Ala 
            100         

<210>  53
<211>  102
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.12链序列


<400>  53
Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Lys Thr Arg Pro Lys 
1               5                   10                  15      
Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile 
            20                  25                  30          
Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro 
        35                  40                  45              
Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr 
    50                  55                  60                  
Arg Leu Lys Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val 
65                  70                  75                  80  
Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu 
                85                  90                  95      
Gln Val Asp Ala Glu Ala 
            100         

<210>  54
<211>  102
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.13链序列


<400>  54
Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Lys Thr Arg Pro Lys 
1               5                   10                  15      
Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile 
            20                  25                  30          
Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro 
        35                  40                  45              
Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr 
    50                  55                  60                  
Arg Leu His Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val 
65                  70                  75                  80  
Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu 
                85                  90                  95      
Gln Val Asp Ala Glu Ala 
            100         

<210>  55
<211>  102
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.14链序列


<400>  55
Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Arg Thr Arg Pro Lys 
1               5                   10                  15      
Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile 
            20                  25                  30          
Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro 
        35                  40                  45              
Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr 
    50                  55                  60                  
Arg Leu Lys Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val 
65                  70                  75                  80  
Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu 
                85                  90                  95      
Gln Val Asp Ala Glu Ala 
            100         

<210>  56
<211>  102
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.15链序列


<400>  56
Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Arg Thr Arg Pro Lys 
1               5                   10                  15      
Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile 
            20                  25                  30          
Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro 
        35                  40                  45              
Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr 
    50                  55                  60                  
Arg Leu His Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val 
65                  70                  75                  80  
Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu 
                85                  90                  95      
Gln Val Asp Ala Glu Ala 
            100         

<210>  57
<211>  102
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.4-L1链序列


<400>  57
Gly Gly Gly Gly Ser Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys 
1               5                   10                  15      
Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile 
            20                  25                  30          
Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro 
        35                  40                  45              
Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr 
    50                  55                  60                  
Arg Leu Thr Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val 
65                  70                  75                  80  
Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu 
                85                  90                  95      
Gln Val Asp Ala Glu Ala 
            100         

<210>  58
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223> O.4-L2链序列


<400>  58
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Ala Pro Arg Phe 
1               5                   10                  15      
Leu Thr Arg Pro Lys Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr 
            20                  25                  30          
Leu Ser Ser Gln Ile Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu 
        35                  40                  45              
Lys Asp Gln Gln Pro Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln 
    50                  55                  60                  
Asp Gly Asp Leu Tyr Arg Leu Thr Ile Leu Asp Leu Ala Leu Gly Asp 
65                  70                  75                  80  
Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe 
                85                  90                  95      
Ala Cys Val Gly Leu Gln Val Asp Ala Glu Ala 
            100                 105         

<210>  59
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  OL.1链序列


<400>  59
Gln Gly Ser Pro Pro Glu Phe Leu Arg Phe Pro Arg Pro Val Arg Val 
1               5                   10                  15      
Val Ser Gly Ala Glu Ala Glu Leu Lys Cys Val Val Leu Gly Glu Pro 
            20                  25                  30          
Pro Pro Val Val Val Trp Glu Lys Gly Gly Gln Gln Leu Ala Ala Ser 
        35                  40                  45              
Glu Arg Leu Ser Phe Pro Ala Asp Gly Ala Glu His Gly Leu Leu Leu 
    50                  55                  60                  
Thr Ala Ala Leu Pro Thr Asp Ala Gly Cys Tyr Val Cys Arg Ala Arg 
65                  70                  75                  80  
Asn Ala Ala Gly Glu Ala Tyr Ala Ala Ala Ala Val Thr Val Leu Glu 
                85                  90                  95      
Pro Pro 
        

<210>  60
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  OL.2链序列


<400>  60
Gln Gly Ser Pro Pro Glu Phe Leu Arg Phe Pro Arg Pro Val Arg Val 
1               5                   10                  15      
Val Ser Gly Ala Glu Ala Glu Leu Lys Cys Val Val Leu Gly Glu Pro 
            20                  25                  30          
Pro Pro Val Val Val Trp Glu Lys Gly Gly Gln Gln Leu Ala Ala Ser 
        35                  40                  45              
Glu Arg Leu Ser Phe Pro Ala Asp Gly Ala Glu His Gly Leu Leu Leu 
    50                  55                  60                  
Thr Ala Ala Leu Pro Thr Asp Ala Gly Val Tyr Val Cys Arg Ala Arg 
65                  70                  75                  80  
Asn Ala Ala Cys Glu Ala Tyr Ala Ala Ala Ala Val Thr Val Leu Glu 
                85                  90                  95      
Pro Pro 
        

<210>  61
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  OL.3链序列


<400>  61
Gln Gly Ser Pro Pro Glu Phe Leu Arg Phe Pro Arg Pro Val Arg Val 
1               5                   10                  15      
Val Ser Gly Ala Glu Ala Glu Leu Lys Cys Val Val Leu Gly Glu Pro 
            20                  25                  30          
Pro Pro Val Val Val Trp Glu Lys Gly Gly Gln Gln Leu Ala Ala Ser 
        35                  40                  45              
Glu Arg Leu Ser Phe Pro Ala Asp Gly Ala Glu His Gly Leu Leu Leu 
    50                  55                  60                  
Thr Ala Ala Leu Pro Thr Asp Ala Gly Val Tyr Val Cys Arg Ala Arg 
65                  70                  75                  80  
Asn Ala Ala Gly Glu Cys Tyr Ala Ala Ala Ala Val Thr Val Leu Glu 
                85                  90                  95      
Pro Pro 
        

<210>  62
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  OL.4链序列


<400>  62
Gln Gly Ser Pro Pro Glu Phe Leu Arg Phe Pro Arg Pro Val Arg Val 
1               5                   10                  15      
Val Ser Gly Ala Glu Ala Glu Leu Lys Ser Val Val Leu Gly Glu Pro 
            20                  25                  30          
Pro Pro Val Val Val Trp Glu Lys Gly Gly Gln Gln Leu Ala Ala Ser 
        35                  40                  45              
Glu Arg Leu Ser Phe Pro Ala Asp Gly Ala Glu His Gly Leu Leu Leu 
    50                  55                  60                  
Thr Ala Ala Leu Pro Thr Asp Ala Gly Cys Tyr Val Ser Arg Ala Arg 
65                  70                  75                  80  
Asn Ala Ala Gly Glu Ala Tyr Ala Ala Ala Ala Val Thr Val Leu Glu 
                85                  90                  95      
Pro Pro 
        

<210>  63
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  OL.5链序列


<400>  63
Gln Gly Ser Pro Pro Glu Phe Leu Arg Phe Pro Arg Pro Val Arg Val 
1               5                   10                  15      
Val Ser Gly Ala Glu Ala Glu Leu Lys Ser Val Val Leu Gly Glu Pro 
            20                  25                  30          
Pro Pro Val Val Val Trp Glu Lys Gly Gly Gln Gln Leu Ala Ala Ser 
        35                  40                  45              
Glu Arg Leu Ser Phe Pro Ala Asp Gly Ala Glu His Gly Leu Leu Leu 
    50                  55                  60                  
Thr Ala Ala Leu Pro Thr Asp Ala Gly Val Tyr Val Ser Arg Ala Arg 
65                  70                  75                  80  
Asn Ala Ala Cys Glu Ala Tyr Ala Ala Ala Ala Val Thr Val Leu Glu 
                85                  90                  95      
Pro Pro 
        

<210>  64
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  OL.6链序列


<400>  64
Gln Gly Ser Pro Pro Glu Phe Leu Arg Phe Pro Arg Pro Val Arg Val 
1               5                   10                  15      
Val Ser Gly Ala Glu Ala Glu Leu Lys Ser Val Val Leu Gly Glu Pro 
            20                  25                  30          
Pro Pro Val Val Val Trp Glu Lys Gly Gly Gln Gln Leu Ala Ala Ser 
        35                  40                  45              
Glu Arg Leu Ser Phe Pro Ala Asp Gly Ala Glu His Gly Leu Leu Leu 
    50                  55                  60                  
Thr Ala Ala Leu Pro Thr Asp Ala Gly Val Tyr Val Ser Arg Ala Arg 
65                  70                  75                  80  
Asn Ala Ala Gly Glu Cys Tyr Ala Ala Ala Ala Val Thr Val Leu Glu 
                85                  90                  95      
Pro Pro 
        

<210>  65
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.7链序列


<400>  65
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Ser Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Ser Leu Ser Leu 
65                  70                  75                  80  
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  66
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.8链序列


<400>  66
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Lys Asp Val Gln Arg Gln Asp Gly Gly Leu Tyr Thr Leu Thr Leu 
65                  70                  75                  80  
Arg Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  67
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.9链序列


<400>  67
Gly Ile Trp Pro Lys Ile Glu Cys Leu Pro Ile Asp Leu Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Met Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Met Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Ser Leu 
65                  70                  75                  80  
Gly Met Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  68
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.10链序列


<400>  68
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ile Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Lys Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Thr Leu 
65                  70                  75                  80  
Arg Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  69
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.11链序列


<400>  69
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Ser Gly Lys Lys Ile Ser Ser Glu Glu 
        35                  40                  45              
Gly Gly Arg Phe His Ile Glu Ser Thr Glu Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Met Asp Val Gln Lys Gln Asp Gly Gly Val Tyr Thr Leu Ser Leu 
65                  70                  75                  80  
Gly Asn Asp Leu Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  70
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.12链序列


<400>  70
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Glu Glu 
        35                  40                  45              
Gly Gly Arg Phe His Ile Glu Ser Thr Glu Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Met Asp Val Gln Lys Gln Asp Gly Gly Val Tyr Thr Leu Ser Leu 
65                  70                  75                  80  
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  71
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.13链序列


<400>  71
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Ser Thr Glu Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Met Asp Val Gln Lys Gln Asp Gly Gly Val Tyr Thr Leu Ser Leu 
65                  70                  75                  80  
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  72
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.14链序列


<400>  72
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Ser Thr Glu Asp Leu Thr Thr Leu Ile 
    50                  55                  60                  
Ile Ser Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Ser Leu Ser Leu 
65                  70                  75                  80  
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  73
<211>  103
<212>  PRT
<213>  人工序列(Artificial Sequence)


<220>
<221>  DOMAIN
<223>  T.10-L1序列


<400>  73
Gly Gly Gly Gly Ser Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ile 
1               5                   10                  15      
Asp Ile Ser Ile Asp Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe 
            20                  25                  30          
Thr Gly Glu Pro Thr Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys 
        35                  40                  45              
Ile His Ser Gln Glu Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp 
    50                  55                  60                  
Leu Thr Thr Leu Ile Ile Lys Asp Val Gln Lys Gln Asp Gly Gly Leu 
65                  70                  75                  80  
Tyr Thr Leu Thr Leu Arg Asn Glu Phe Gly Ser Asp Ser Ala Thr Val 
                85                  90                  95      
Asn Ile His Ile Arg Ser Ile 
            100             

<210>  74
<211>  103
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.15链序列


<400>  74
Lys Ala Gly Ile Arg Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser 
1               5                   10                  15      
Asp Ile Ser Ile Asp Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe 
            20                  25                  30          
Thr Gly Glu Pro Thr Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys 
        35                  40                  45              
Ile His Ser Gln Glu Gln Gly Arg Phe His Ile Glu Ser Thr Glu Asp 
    50                  55                  60                  
Leu Thr Thr Leu Ile Ile Ser Asp Val Gln Lys Gln Asp Gly Gly Leu 
65                  70                  75                  80  
Tyr Ser Leu Ser Leu Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val 
                85                  90                  95      
Asn Ile His Ile Arg Ser Ile 
            100             

<210>  75
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>   T.15-L1链序列


<400>  75
Gly Gly Gly Gly Ser Lys Ala Gly Ile Arg Gly Ile Pro Pro Lys Ile 
1               5                   10                  15      
Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp Glu Gly Lys Val Leu Thr 
            20                  25                  30          
Val Ala Ser Ala Phe Thr Gly Glu Pro Thr Pro Glu Val Thr Trp Ser 
        35                  40                  45              
Thr Gly Gly Arg Lys Ile His Ser Gln Glu Gln Gly Arg Phe His Ile 
    50                  55                  60                  
Glu Ser Thr Glu Asp Leu Thr Thr Leu Ile Ile Ser Asp Val Gln Lys 
65                  70                  75                  80  
Gln Asp Gly Gly Leu Tyr Ser Leu Ser Leu Gly Asn Glu Phe Gly Ser 
                85                  90                  95      
Asp Ser Ala Thr Val Asn Ile His Ile Arg Ser Ile 
            100                 105             

<210>  76
<211>  103
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.14-L1链序列


<400>  76
Gly Gly Gly Gly Ser Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser 
1               5                   10                  15      
Asp Ile Ser Ile Asp Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe 
            20                  25                  30          
Thr Gly Glu Pro Thr Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys 
        35                  40                  45              
Ile His Ser Gln Glu Gln Gly Arg Phe His Ile Glu Ser Thr Glu Asp 
    50                  55                  60                  
Leu Thr Thr Leu Ile Ile Ser Asp Val Gln Lys Gln Asp Gly Gly Leu 
65                  70                  75                  80  
Tyr Ser Leu Ser Leu Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val 
                85                  90                  95      
Asn Ile His Ile Arg Ser Ile 
            100             

<210>  77
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.17链序列


<400>  77
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys Ser Tyr Thr Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Ser Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  78
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.18链序列


<400>  78
Ser Glu Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val Ser 
1               5                   10                  15      
Glu Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asp Pro Pro 
            20                  25                  30          
Pro Glu Val Thr Trp Glu Lys Asp Gln Gln Pro Ile Thr Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Val Tyr Arg Leu Glu Ile Leu 
    50                  55                  60                  
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Gly 
    

<210>  79
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.19链序列


<400>  79
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Leu Ala Met Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro Val Ala Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Leu Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  80
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.20链序列


<400>  80
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  81
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.21链序列


<400>  81
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Leu Pro Val Thr Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Thr Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Glu Val Gly Ala Glu 
                85                  90                  95      
Ala 
    

<210>  82
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.22链序列


<400>  82
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ser Tyr Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Ser Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Gln Leu Pro Val Thr Ala Gly Ala 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Glu Val Gly Ala Glu 
                85                  90                  95      
Ala 
    

<210>  83
<211>  102
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.20-L1链序列


<400>  83
Gly Gly Gly Gly Ser Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu 
1               5                   10                  15      
Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile 
            20                  25                  30          
Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro 
        35                  40                  45              
Val Thr Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr 
    50                  55                  60                  
Arg Leu Lys Ile Leu Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val 
65                  70                  75                  80  
Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Leu Gly Leu 
                85                  90                  95      
Gln Val Asp Ala Glu Ala 
            100         

<210>  84
<211>  102
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.22-L1链序列


<400>  84
Gly Gly Gly Gly Ser Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu 
1               5                   10                  15      
Ser Tyr Val Val Ser Val Gly Lys Asp Ala Ser Leu Ser Ser Gln Ile 
            20                  25                  30          
Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Leu Pro 
        35                  40                  45              
Val Thr Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr 
    50                  55                  60                  
Arg Leu Lys Ile Leu Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val 
65                  70                  75                  80  
Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu 
                85                  90                  95      
Glu Val Gly Ala Glu Ala 
            100         

<210>  85
<211>  102
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.23链序列


<400>  85
Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu 
1               5                   10                  15      
Ser Tyr Val Val Ser Val Gly Lys Asp Ala Ser Leu Ser Ser Gln Ile 
            20                  25                  30          
Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Leu Pro 
        35                  40                  45              
Val Thr Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr 
    50                  55                  60                  
Arg Leu Lys Ile Leu Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val 
65                  70                  75                  80  
Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu 
                85                  90                  95      
Glu Val Gly Ala Glu Ala 
            100         

<210>  86
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.23-L1序列


<400>  86
Gly Gly Gly Gly Ser Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe 
1               5                   10                  15      
Leu Thr Arg Pro Leu Ser Tyr Val Val Ser Val Gly Lys Asp Ala Ser 
            20                  25                  30          
Leu Ser Ser Gln Ile Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu 
        35                  40                  45              
Lys Asp Gln Leu Pro Val Thr Ala Gly Ala Arg Phe Arg Leu Ala Gln 
    50                  55                  60                  
Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu Asp Leu Gln Leu Ser Asp 
65                  70                  75                  80  
Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe 
                85                  90                  95      
Ala Cys Val Gly Leu Glu Val Gly Ala Glu Ala 
            100                 105         

<210>  87
<211>  452
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  DI-1链1 (DI-1-H1) 的序列


<400>  87
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Thr Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Thr Thr Val Ile Met Ser Trp Phe Asp Pro Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210>  88
<211>  215
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  DI-1链2(DI-1-L1) 的序列


<400>  88
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Arg 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Phe Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210>  89
<211>  451
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  DI-1链3 (DI-1-H2) 的序列


<400>  89
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Gly Tyr 
            20                  25                  30          
Asp Leu Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ile Ile Trp Gly Asp Gly Thr Thr Asp Tyr Asn Ser Ala Val Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Gly Tyr Trp Tyr Ala Thr Ser Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Ile 
        115                 120                 125             
Pro Pro Lys Ile Glu Cys Leu Pro Ile Asp Ile Ser Ile Asp Glu Gly 
    130                 135                 140                 
Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr Pro Glu 
145                 150                 155                 160 
Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu Gln Gly 
                165                 170                 175     
Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile Ile Lys 
            180                 185                 190         
Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Thr Leu Arg Asn 
        195                 200                 205             
Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg Ser Ile 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210>  90
<211>  209
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  DI-1链4(DI-1-L2) 的序列


<400>  90
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Arg Phe His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Glu His Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val Ser 
        115                 120                 125             
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
    130                 135                 140                 
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Ala 
145                 150                 155                 160 
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
                165                 170                 175     
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
            180                 185                 190         
Ala Ile Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
        195                 200                 205             
Ala 
    

<210>  91
<211>  453
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU1链1(BU1-H1) 的序列


<400>  91
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
            20                  25                  30          
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  
Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
            100                 105                 110         
Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             
Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             
Leu Ser Pro Gly Lys 
    450             

<210>  92
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU1链2(BU1-L1) 的序列


<400>  92
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      
Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      
Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         
Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             
Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 
Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 
Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     
Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         
Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             
Ala Pro Thr Glu Cys Ser 
    210                 

<210>  93
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU1链3(BU1-H2) 的序列


<400>  93
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          
Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Ile Pro Pro 
        115                 120                 125             
Lys Ile Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp Glu Gly Lys Val 
    130                 135                 140                 
Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr Pro Glu Val Thr 
145                 150                 155                 160 
Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu Gln Gly Arg Phe 
                165                 170                 175     
His Ile Glu Ser Thr Glu Asp Leu Thr Thr Leu Ile Ile Ser Asp Val 
            180                 185                 190         
Gln Lys Gln Asp Gly Gly Leu Tyr Ser Leu Ser Leu Gly Asn Glu Phe 
        195                 200                 205             
Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg Ser Ile Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  94
<211>  209
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU1链4(BU1-L2) 的序列


<400>  94
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ser Tyr Val Val Ser 
        115                 120                 125             
Val Gly Lys Asp Ala Ser Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
    130                 135                 140                 
Pro Gln Val Ser Trp Glu Lys Asp Gln Leu Pro Val Thr Ala Gly Ala 
145                 150                 155                 160 
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
                165                 170                 175     
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
            180                 185                 190         
Ala Ile Gly Glu Ala Phe Ala Cys Val Gly Leu Glu Val Gly Ala Glu 
        195                 200                 205             
Ala 
    

<210>  95
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU2链1(BU2-H1) /BU4链1(BU4-H1)/BU5链3(BU5-H2) 的序列


<400>  95
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          
Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  96
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU2链2(BU2-L1) /BU3链4(BU3-L2)/BU4链2(BU4-L1)/BU5链4(BU5-L2) 的序列


<400>  96
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  97
<211>  453
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU2链3(BU2-H2) 的序列


<400>  97
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
            20                  25                  30          
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  
Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
            100                 105                 110         
Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp 
    130                 135                 140                 
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
145                 150                 155                 160 
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
                165                 170                 175     
Gln Gly Arg Phe His Ile Glu Ser Thr Glu Asp Leu Thr Thr Leu Ile 
            180                 185                 190         
Ile Ser Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Ser Leu Ser Leu 
        195                 200                 205             
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
    210                 215                 220                 
Ser Ile Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         
Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             
Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             
Leu Ser Pro Gly Lys 
    450             

<210>  98
<211>  215
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU2链4(BU2-L2) 的序列


<400>  98
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      
Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      
Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         
Ser Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro 
        115                 120                 125             
Leu Ser Tyr Val Val Ser Val Gly Lys Asp Ala Ser Leu Ser Ser Gln 
    130                 135                 140                 
Ile Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Leu 
145                 150                 155                 160 
Pro Val Thr Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu 
                165                 170                 175     
Tyr Arg Leu Lys Ile Leu Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr 
            180                 185                 190         
Val Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Val Gly 
        195                 200                 205             
Leu Glu Val Gly Ala Glu Ala 
    210                 215 

<210>  99
<211>  453
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU3链1(BU3-H1) 的序列


<400>  99
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
            20                  25                  30          
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  
Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
            100                 105                 110         
Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser Asp Ile Ser Ile Asp 
    130                 135                 140                 
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
145                 150                 155                 160 
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
                165                 170                 175     
Gln Gly Arg Phe His Ile Glu Ser Thr Glu Asp Leu Thr Thr Leu Ile 
            180                 185                 190         
Ile Ser Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Ser Leu Ser Leu 
        195                 200                 205             
Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
    210                 215                 220                 
Ser Ile Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             
Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             
Leu Ser Pro Gly Lys 
    450             

<210>  100
<211>  215
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU3链2(BU3-L1) /BU4链4(BU4-L2) 的序列


<400>  100
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      
Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      
Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         
Ser Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro 
        115                 120                 125             
Leu Ser Tyr Val Val Ser Val Gly Lys Asp Ala Ser Leu Ser Ser Gln 
    130                 135                 140                 
Ile Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Leu 
145                 150                 155                 160 
Pro Val Thr Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu 
                165                 170                 175     
Tyr Arg Leu Lys Ile Leu Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr 
            180                 185                 190         
Val Ser Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Val Gly 
        195                 200                 205             
Leu Glu Val Gly Ala Glu Ala 
    210                 215 

<210>  101
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU3链3(BU3-H2) 的序列


<400>  101
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          
Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  102
<211>  458
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU4链3(BU4-H2) 的序列


<400>  102
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
            20                  25                  30          
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  
Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
            100                 105                 110         
Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Lys Ala Gly Ile Arg Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ser 
    130                 135                 140                 
Asp Ile Ser Ile Asp Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe 
145                 150                 155                 160 
Thr Gly Glu Pro Thr Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys 
                165                 170                 175     
Ile His Ser Gln Glu Gln Gly Arg Phe His Ile Glu Ser Thr Glu Asp 
            180                 185                 190         
Leu Thr Thr Leu Ile Ile Ser Asp Val Gln Lys Gln Asp Gly Gly Leu 
        195                 200                 205             
Tyr Ser Leu Ser Leu Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val 
    210                 215                 220                 
Asn Ile His Ile Arg Ser Ile Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         
Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             
Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
    370                 375                 380                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     
Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             

<210>  103
<211>  453
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU5链1(BU5-H1) 的序列


<400>  103
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
            20                  25                  30          
Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  
Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
            100                 105                 110         
Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ile Asp Ile Ser Ile Asp 
    130                 135                 140                 
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
145                 150                 155                 160 
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
                165                 170                 175     
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile 
            180                 185                 190         
Ile Lys Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Thr Leu 
        195                 200                 205             
Arg Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
    210                 215                 220                 
Ser Ile Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         
Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             
Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             
Leu Ser Pro Gly Lys 
    450             

<210>  104
<211>  210
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  BU5链2(BU5-L1) 的序列


<400>  104
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      
Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      
Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu Gly Gly Gly Gly 
            100                 105                 110         
Ser Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val 
        115                 120                 125             
Ser Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro 
    130                 135                 140                 
Thr Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly 
145                 150                 155                 160 
Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile 
                165                 170                 175     
Leu Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg 
            180                 185                 190         
Asn Ala Ile Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala 
        195                 200                 205             
Glu Ala 
    210 

<210>  105
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  A0抗体VH序列


<400>  105
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Glu Tyr Ile Ser Tyr Trp 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  106
<211>  109
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  A0抗体VL序列


<400>  106
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          
Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      
Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210>  107
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  FA-1链1(FA-1-H1) 的序列


<400>  107
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Thr 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Ser 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Ala Arg Leu Tyr Ala Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Ala Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Ile Pro Pro 
        115                 120                 125             
Lys Ile Glu Cys Leu Pro Ile Asp Ile Ser Ile Asp Glu Gly Lys Val 
    130                 135                 140                 
Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr Pro Glu Val Thr 
145                 150                 155                 160 
Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu Gln Gly Arg Phe 
                165                 170                 175     
His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile Ile Lys Asp Val 
            180                 185                 190         
Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Thr Leu Arg Asn Glu Phe 
        195                 200                 205             
Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg Ser Ile Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  108
<211>  212
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  FA-1链2(FA-1-L1) 的序列


<400>  108
Asp Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Ser 
            20                  25                  30          
His Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Met 
        35                  40                  45              
Leu Ile Tyr Asn Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  
Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Ile His Val Asp Arg 
                85                  90                  95      
Asp Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         
Gly Gly Ser Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe 
        115                 120                 125             
Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly 
    130                 135                 140                 
Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr 
145                 150                 155                 160 
Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu 
                165                 170                 175     
Lys Ile Leu Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg 
            180                 185                 190         
Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val 
        195                 200                 205             
Asp Ala Glu Ala 
    210         

<210>  109
<211>  455
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  FA-1链3(FA-1-H2) 的序列


<400>  109
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Glu Tyr Ile Ser Tyr Trp 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 
Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys 
        355                 360                 365             
Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys 
    450                 455 

<210>  110
<211>  216
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  FA-1链4(FA-1-L2) 的序列


<400>  110
Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          
Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      
Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val 
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     

<210>  111
<211>  447
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  hB7H3抗原蛋白的序列


<400>  111
Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr 
1               5                   10                  15      
Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu 
            20                  25                  30          
Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val 
        35                  40                  45              
His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg 
    50                  55                  60                  
Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg 
65                  70                  75                  80  
Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val 
                85                  90                  95      
Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala 
            100                 105                 110         
Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg 
        115                 120                 125             
Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro 
    130                 135                 140                 
Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly 
145                 150                 155                 160 
Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val 
                165                 170                 175     
His Ser Ile Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys 
            180                 185                 190         
Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr 
        195                 200                 205             
Ile Thr Pro Gln Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro 
    210                 215                 220                 
Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys 
225                 230                 235                 240 
Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile 
                245                 250                 255     
Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly 
            260                 265                 270         
Arg Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp 
        275                 280                 285             
Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val 
    290                 295                 300                 
Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly 
305                 310                 315                 320 
Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser 
                325                 330                 335     
Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
            340                 345                 350         
Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp 
        355                 360                 365             
Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln 
    370                 375                 380                 
Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val 
385                 390                 395                 400 
Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val 
                405                 410                 415     
Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met 
            420                 425                 430         
Thr Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
        435                 440                 445         

<210>  112
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  hCD3抗原的δ亚基序列


<400>  112
Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys 
1               5                   10                  15      
Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser 
            20                  25                  30          
Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly 
        35                  40                  45              
Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr 
    50                  55                  60                  
Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro 
65                  70                  75                  80  
Ala Thr Val Ala Ser Ala Glu Asn Ala Gln Cys Glu Lys Glu Leu Gln 
                85                  90                  95      
Ala Leu Glu Lys Glu Asn Ala Gln Leu Glu Trp Glu Leu Gln Ala Leu 
            100                 105                 110         
Glu Lys Glu Leu Ala Gln Asp Tyr Lys Asp Asp Asp Asp Lys 
        115                 120                 125     

<210>  113
<211>  143
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  hCD3抗原的ε亚基序列


<400>  113
Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      
Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          
Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              
Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  
Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  
Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      
Cys Glu Asn Cys Met Glu Met Asp Ala Lys Asn Ala Gln Cys Lys Lys 
            100                 105                 110         
Lys Leu Gln Ala Leu Lys Lys Lys Asn Ala Gln Leu Lys Trp Lys Leu 
        115                 120                 125             
Gln Ala Leu Lys Lys Lys Leu Ala Gln His His His His His His 
    130                 135                 140             

<210>  114
<211>  482
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HJ-1-H1序列


<400>  114
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          
Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Thr Ser Ile Ser Tyr Glu Gly Asp Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gln Thr Leu Arg Glu Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
        115                 120                 125             
Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
    130                 135                 140                 
Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
145                 150                 155                 160 
Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
                165                 170                 175     
Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Gln Asp Ser Arg 
            180                 185                 190         
Tyr Ala Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
        195                 200                 205             
Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
    210                 215                 220                 
Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
225                 230                 235                 240 
Ser Ala Glu Ala Trp Gly Arg Ala Ser Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     
Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
    370                 375                 380                 
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
385                 390                 395                 400 
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His 
465                 470                 475                 480 
His His 
        

<210>  115
<211>  203
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>   CHAIN
<223>  HJ-1-L1序列


<400>  115
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Asn Tyr 
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Thr Ser Asn Leu Glu Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Lys Glu Phe Pro Arg 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Lys Pro Asp Ile Gln 
            100                 105                 110         
Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp 
        115                 120                 125             
Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Gln Val Ser 
    130                 135                 140                 
Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp 
145                 150                 155                 160 
Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Gln 
                165                 170                 175     
Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Gln Asn Ser Ile Ile Pro 
            180                 185                 190         
Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200             

<210>  116
<211>  457
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HJ-1-H2/HJ-3-H2序列


<400>  116
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          
Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Asp Pro Gly Val Gly Asp Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Ile Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Asp Asn Thr Gly Thr Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser 
        355                 360                 365             
Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys Asp Tyr Lys Asp Asp Asp Asp Lys 
    450                 455         

<210>  117
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>   CHAIN
<223>  HJ-1-L2/HJ-3-L2序列


<400>  117
Ser Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Ser Asp 
            20                  25                  30          
Val Thr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Val Ser Glu His Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln His His Arg Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  118
<211>  456
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HJ-2-H1/HJ-4-H1序列


<400>  118
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          
Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Thr Ser Ile Ser Tyr Glu Gly Asp Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gln Thr Leu Arg Glu Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             
Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             
Asp Tyr Lys Asp Asp Asp Asp Lys 
    450                 455     

<210>  119
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HJ-2-L1/HJ-4-L1序列


<400>  119
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Asn Tyr 
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Thr Ser Asn Leu Glu Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Lys Glu Phe Pro Arg 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  120
<211>  483
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HJ-1-H2序列


<400>  120
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          
Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Asp Pro Gly Val Gly Asp Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Ile Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Asp Asn Thr Gly Thr Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Leu Glu Asp Leu Lys Asn Val Phe Pro 
        115                 120                 125             
Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr 
    130                 135                 140                 
Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His 
145                 150                 155                 160 
Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
                165                 170                 175     
Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Gln Asp Ser 
            180                 185                 190         
Arg Tyr Ala Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln 
        195                 200                 205             
Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser 
    210                 215                 220                 
Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile 
225                 230                 235                 240 
Val Ser Ala Glu Ala Trp Gly Arg Ala Ser Asp Lys Thr His Thr Cys 
                245                 250                 255     
Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
    370                 375                 380                 
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
385                 390                 395                 400 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His 
465                 470                 475                 480 
His His His 
            

<210>  121
<211>  203
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HJ-2-L2序列


<400>  121
Ser Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Ser Asp 
            20                  25                  30          
Val Thr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Val Ser Glu His Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln His His Arg Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Lys Pro Asp Ile Gln 
            100                 105                 110         
Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp 
        115                 120                 125             
Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Gln Val Ser 
    130                 135                 140                 
Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp 
145                 150                 155                 160 
Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Gln 
                165                 170                 175     
Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Gln Asn Ser Ile Ile Pro 
            180                 185                 190         
Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200             

<210>  122
<211>  454
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HJ-3-H1序列


<400>  122
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          
Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Thr Ser Ile Ser Tyr Glu Gly Asp Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gln Thr Leu Arg Glu Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Ile Pro Pro Lys 
        115                 120                 125             
Ile Glu Cys Leu Pro Ile Asp Ile Ser Ile Asp Glu Gly Lys Val Leu 
    130                 135                 140                 
Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr Pro Glu Val Thr Trp 
145                 150                 155                 160 
Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu Gln Gly Arg Phe His 
                165                 170                 175     
Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile Ile Lys Asp Val Gln 
            180                 185                 190         
Lys Gln Asp Gly Gly Leu Tyr Thr Leu Thr Leu Arg Asn Glu Phe Gly 
        195                 200                 205             
Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg Ser Ile Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             
His His His His His His 
    450                 

<210>  123
<211>  209
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HJ-3-L1序列


<400>  123
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Asn Tyr 
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Thr Ser Asn Leu Glu Val Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Lys Glu Phe Pro Arg 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val Ser 
        115                 120                 125             
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
    130                 135                 140                 
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Ala 
145                 150                 155                 160 
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
                165                 170                 175     
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
            180                 185                 190         
Ala Ile Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
        195                 200                 205             
Ala 
    

<210>  124
<211>  455
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HJ-4-H2序列


<400>  124
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          
Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Asp Pro Gly Val Gly Asp Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Ile Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Asp Asn Thr Gly Thr Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Ile Pro Pro 
        115                 120                 125             
Lys Ile Glu Cys Leu Pro Ile Asp Ile Ser Ile Asp Glu Gly Lys Val 
    130                 135                 140                 
Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr Pro Glu Val Thr 
145                 150                 155                 160 
Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu Gln Gly Arg Phe 
                165                 170                 175     
His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile Ile Lys Asp Val 
            180                 185                 190         
Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Thr Leu Arg Asn Glu Phe 
        195                 200                 205             
Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg Ser Ile Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys His His His His His His 
    450                 455 

<210>  125
<211>  209
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  HJ-4-L2序列


<400>  125
Ser Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Ser Asp 
            20                  25                  30          
Val Thr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Val Ser Glu His Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln His His Arg Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val Ser 
        115                 120                 125             
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr 
    130                 135                 140                 
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Ala 
145                 150                 155                 160 
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
                165                 170                 175     
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
            180                 185                 190         
Ala Ile Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
        195                 200                 205             
Ala 
    

<210>  126
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  J1重链序列


<400>  126
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          
Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Asp Pro Gly Val Gly Asp Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Ile Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Asp Asn Thr Gly Thr Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr 
                245                 250                 255     
Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  127
<211>  103
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.6链序列


<400>  127
Lys Ala Gly Ile Arg Gly Ile Pro Pro Lys Ile Glu Ala Leu Pro Ser 
1               5                   10                  15      
Asp Ile Ser Ile Asp Glu Gly Lys Val Leu Thr Val Ala Cys Ala Phe 
            20                  25                  30          
Thr Gly Glu Pro Thr Pro Glu Val Thr Trp Ser Cys Gly Gly Arg Lys 
        35                  40                  45              
Ile His Ser Gln Glu Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp 
    50                  55                  60                  
Leu Thr Thr Leu Ile Ile Met Asp Val Gln Lys Gln Asp Gly Gly Leu 
65                  70                  75                  80  
Tyr Thr Leu Ser Leu Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val 
                85                  90                  95      
Asn Ile His Ile Arg Ser Ile 
            100             

<210>  128
<211>  102
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.16链序列


<400>  128
Asp Gln Pro Gln Phe Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys 
1               5                   10                  15      
Ala Phe Val Val Ser Val Gly Lys Asp Ala Thr Leu Ser Cys Gln Ile 
            20                  25                  30          
Val Gly Asn Pro Thr Pro Gln Val Ser Trp Glu Lys Asp Gln Gln Pro 
        35                  40                  45              
Val Ala Ala Gly Ala Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr 
    50                  55                  60                  
Arg Leu Thr Ile Leu Asp Leu Ala Leu Gly Asp Ser Gly Gln Tyr Val 
65                  70                  75                  80  
Cys Arg Ala Arg Asn Ala Ile Gly Glu Ala Phe Ala Ala Val Gly Leu 
                85                  90                  95      
Gln Val Asp Ala Glu Ala 
            100         

<210>  129
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.16链序列


<400>  129
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ile Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Ser Thr Thr Leu Thr 
    50                  55                  60                  
Ile Lys Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Thr Leu 
65                  70                  75                  80  
Arg Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  130
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.17链序列


<400>  130
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ile Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Cys Leu Thr Val Ala Ser Ala Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Ser Thr Thr Leu Thr 
    50                  55                  60                  
Ile Lys Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Thr Leu 
65                  70                  75                  80  
Arg Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  131
<211>  98
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  T.18链序列


<400>  131
Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ile Asp Ile Ser Ile Asp 
1               5                   10                  15      
Glu Gly Lys Val Leu Thr Val Ala Ser Cys Phe Thr Gly Glu Pro Thr 
            20                  25                  30          
Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile His Ser Gln Glu 
        35                  40                  45              
Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Ser Thr Thr Leu Thr 
    50                  55                  60                  
Ile Lys Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Thr Leu 
65                  70                  75                  80  
Arg Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg 
                85                  90                  95      
Ser Ile 
        

<210>  132
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.24链序列


<400>  132
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys Ala Phe Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Phe 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala Ile Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  133
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.25链序列


<400>  133
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys Ala Ser Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Phe 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala His Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  134
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.26链序列


<400>  134
Ser Gly Cys Pro Arg Phe Leu Thr Arg Pro Lys Ala Ser Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Phe 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala His Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  135
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.27链序列


<400>  135
Ser Gly Ala Pro Arg Phe Leu Thr Cys Pro Lys Ala Ser Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Phe 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala His Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  136
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.28链序列

<400>  136
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys Ala Ser Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Cys Gln Ile Val Gly Asn Pro Phe 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Cys Arg Ala Arg Asn 
65                  70                  75                  80  
Ala His Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  137
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.29链序列


<400>  137
Ser Gly Cys Pro Arg Phe Leu Thr Arg Pro Lys Ala Ser Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Cys Gln Ile Val Gly Asn Pro Phe 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Cys Arg Ala Arg Asn 
65                  70                  75                  80  
Ala His Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  138
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.30链序列


<400>  138
Ser Gly Ala Pro Arg Phe Leu Thr Cys Pro Lys Ala Ser Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Cys Gln Ile Val Gly Asn Pro Phe 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Leu Gln Leu Ser Asp Ser Gly Gln Tyr Val Cys Arg Ala Arg Asn 
65                  70                  75                  80  
Ala His Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  139
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.31链序列


<400>  139
Ser Gly Ala Pro Arg Phe Leu Thr Arg Pro Lys Ala Ser Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Phe 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Cys Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala His Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Cys Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  140
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.32链序列


<400>  140
Ser Gly Cys Pro Arg Phe Leu Thr Arg Pro Lys Ala Ser Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Phe 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Cys Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala His Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Cys Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  141
<211>  97
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  O.33链序列


<400>  141
Ser Gly Ala Pro Arg Phe Leu Thr Cys Pro Lys Ala Ser Val Val Ser 
1               5                   10                  15      
Val Gly Lys Asp Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Phe 
            20                  25                  30          
Pro Gln Val Ser Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val 
        35                  40                  45              
Arg Phe Arg Leu Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu 
    50                  55                  60                  
Asp Cys Gln Leu Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn 
65                  70                  75                  80  
Ala His Gly Glu Ala Phe Ala Cys Leu Gly Leu Gln Cys Asp Ala Glu 
                85                  90                  95      
Ala 
    

<210>  142
<211>  448
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  PL-1第一重链序列


<400>  142
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Thr Pro Ser Ser Gly Phe Ala Met Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Ser Gly Ala Pro 
        115                 120                 125             
Arg Phe Leu Thr Arg Pro Leu Ala Phe Val Val Ser Val Gly Lys Asp 
    130                 135                 140                 
Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Thr Pro Gln Val Ser 
145                 150                 155                 160 
Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Ala Arg Phe Arg Leu 
                165                 170                 175     
Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu Asp Leu Gln Leu 
            180                 185                 190         
Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn Ala Ile Gly Glu 
        195                 200                 205             
Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu Ala Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             

<210>  143
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  PL-1第一轻链序列


<400>  143
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Lys Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gly Gly Gly Ser Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ile Asp 
        115                 120                 125             
Ile Ser Ile Asp Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr 
    130                 135                 140                 
Gly Glu Pro Thr Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile 
145                 150                 155                 160 
His Ser Gln Glu Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu 
                165                 170                 175     
Thr Thr Leu Ile Ile Lys Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr 
            180                 185                 190         
Thr Leu Thr Leu Arg Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn 
        195                 200                 205             
Ile His Ile Arg Ser Ile 
    210                 

<210>  144
<211>  448
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  PL-1第二重链序列


<400>  144
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys 
        355                 360                 365             
Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             

<210>  145
<211>  215
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  PL-1第二轻链序列


<400>  145
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210>  146
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  P-O-T的轻链1序列


<400>  146
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Lys Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         
Gly Gly Gly Ser Gly Ile Pro Pro Lys Ile Glu Cys Leu Pro Ile Asp 
        115                 120                 125             
Ile Ser Ile Asp Glu Gly Lys Val Leu Thr Val Ala Ser Ala Phe Thr 
    130                 135                 140                 
Gly Glu Pro Thr Pro Glu Val Thr Trp Ser Thr Gly Gly Arg Lys Ile 
145                 150                 155                 160 
His Ser Gln Glu Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu 
                165                 170                 175     
Thr Thr Leu Ile Ile Lys Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr 
            180                 185                 190         
Thr Leu Thr Leu Arg Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn 
        195                 200                 205             
Ile His Ile Arg Ser Ile 
    210                 

<210>  147
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  P-O-T的轻链2序列


<400>  147
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asn Ala Arg Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Tyr His Ser Gly Ser Pro Leu 
                85                  90                  95      
Pro Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  148
<211>  675
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  P-O-T重链序列


<400>  148
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Thr Pro Ser Ser Gly Phe Ala Met Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Ser Gly Ala Pro 
        115                 120                 125             
Arg Phe Leu Thr Arg Pro Lys Ala Phe Val Val Ser Val Gly Lys Asp 
    130                 135                 140                 
Ala Thr Leu Ser Ser Gln Ile Val Gly Asn Pro Phe Pro Gln Val Ser 
145                 150                 155                 160 
Trp Glu Lys Asp Lys Gln Pro Val Thr Ala Gly Val Arg Phe Arg Leu 
                165                 170                 175     
Ala Gln Asp Gly Asp Leu Tyr Arg Leu Lys Ile Leu Asp Leu Gln Leu 
            180                 185                 190         
Ser Asp Ser Gly Gln Tyr Val Ser Arg Ala Arg Asn Ala Ile Gly Glu 
        195                 200                 205             
Ala Phe Ala Cys Leu Gly Leu Gln Val Asp Ala Glu Ala Gly Gly Gly 
    210                 215                 220                 
Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
225                 230                 235                 240 
Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                245                 250                 255     
Asn Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
            260                 265                 270         
Trp Met Gly Arg Ile Asp Pro Asp Ser Thr Gly Ser Lys Tyr Asn Glu 
        275                 280                 285             
Lys Phe Lys Thr Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr 
    290                 295                 300                 
Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
305                 310                 315                 320 
Tyr Cys Ala Arg Glu Gly Ala Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly 
                325                 330                 335     
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
            340                 345                 350         
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
        355                 360                 365             
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
    370                 375                 380                 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
385                 390                 395                 400 
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
                405                 410                 415     
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
            420                 425                 430         
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
        435                 440                 445             
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    450                 455                 460                 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
465                 470                 475                 480 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                485                 490                 495     
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            500                 505                 510         
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        515                 520                 525             
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    530                 535                 540                 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
545                 550                 555                 560 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                565                 570                 575     
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            580                 585                 590         
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        595                 600                 605             
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    610                 615                 620                 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
625                 630                 635                 640 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                645                 650                 655     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            660                 665                 670         
Pro Gly Lys 
        675 

<210>  149
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  h1708-04轻链序列


<400>  149
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asn Ala Arg Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Tyr His Ser Gly Ser Pro Leu 
                85                  90                  95      
Pro Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  150
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  h1708-04重链序列


<400>  150
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asp Pro Asp Ser Thr Gly Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Thr Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Ala Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  151
<211>  218
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  h1831K轻链序列


<400>  151
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Lys Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210>  152
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  CHAIN
<223>  h1831K重链序列


<400>  152
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Thr Pro Ser Ser Gly Phe Ala Met Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  153
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1708-04轻链可变区序列


<400>  153
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asn Ala Arg Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Tyr His Ser Gly Ser Pro Leu 
                85                  90                  95      
Pro Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  154
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1708-04重链可变区序列


<400>  154
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asp Pro Asp Ser Thr Gly Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Thr Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Ala Tyr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210>  155
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1831K轻链可变区序列


<400>  155
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Ile His 
            20                  25                  30          
Gly Thr His Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Lys Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Val Glu Ala Glu Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Ser Phe 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210>  156
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1831K重链可变区序列


<400>  156
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Thr Pro Ser Ser Gly Phe Ala Met Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  157
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1708-04的HCDR1序列


<400>  157
Asn Tyr Trp Met His 
1               5   

<210>  158
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1708-04的HCDR2序列


<400>  158
Arg Ile Asp Pro Asp Ser Thr Gly Ser Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Thr 
    

<210>  159
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1708-04的HCDR3序列


<400>  159
Glu Gly Ala Tyr Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  

<210>  160
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1708-04的LCDR1序列


<400>  160
Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      

<210>  161
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1708-04的LCDR2序列


<400>  161
Asn Ala Arg Thr Leu Ala Glu 
1               5           

<210>  162
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1708-04的LCDR3序列


<400>  162
Gln Tyr His Ser Gly Ser Pro Leu Pro 
1               5                   

<210>  163
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1831K的HCDR1序列


<400>  163
Ser Tyr Trp Met His 
1               5   

<210>  164
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1831K的HCDR2序列


<400>  164
Arg Ile Thr Pro Ser Ser Gly Phe Ala Met Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Asn 
    

<210>  165
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1831K的HCDR3序列


<400>  165
Gly Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr 
1               5                   10  

<210>  166
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1831K的LCDR1序列


<400>  166
Arg Ala Ser Glu Ser Val Ser Ile His Gly Thr His Leu Met His 
1               5                   10                  15  

<210>  167
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1831K的LCDR2序列


<400>  167
Ala Ala Ser Lys Leu Glu Ser 
1               5           

<210>  168
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  h1831K的LCDR3序列


<400>  168
Gln Gln Ser Phe Glu Asp Pro Leu Thr 
1               5                   

<210>  169
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  L0的重链可变区序列


<400>  169
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  170
<211>  108
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  L0的轻链可变区序列


<400>  170
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210>  171
<211>  119
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  J1重链可变区序列


<400>  171
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          
Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Asp Pro Gly Val Gly Asp Thr Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Ile Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Asp Asn Thr Gly Thr Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  172
<211>  107
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  J1轻链可变区序列


<400>  172
Ser Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Ser Asp 
            20                  25                  30          
Val Thr Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Val Ser Glu His Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln His His Arg Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  173
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  CH1的C端截短序列1的氨基酸序列


<400>  173
Ala Ser Thr Lys Gly 
1               5   

<210>  174
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  CL的C端截短的序列1的氨基酸序列


<400>  174
Arg Thr Val Ala Ser 
1               5   

<210>  175
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  连接子序列1的氨基酸序列


<400>  175
Gly Gly Gly Gly Ser 
1               5   

<210>  176
<211>  10
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  连接子序列2的氨基酸序列


<400>  176
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210>  177
<211>  227
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  hole-IgG1重链恒定区的Fc部分序列


<400>  177
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             
Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly Lys 
225         

<210>  178
<211>  227
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  knob-IgG1重链恒定区的Fc部分序列


<400>  178
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             
Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly Lys 
225         

<210>  179
<211>  103
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  DOMAIN
<223>  IgG1重链恒定区的CH1部分序列


<400>  179
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys 
            100             


<210>  180
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Titin N端 5AA

<400>  180

Lys Ala Gly Ile Arg 
1               5   


<210>  181
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  Obscurin N端 5AA

<400>  181

Asp Gln Pro Gln Phe 
1               5   


