                         SEQUENCE LISTING

<110>  ٲҩ(̨)ɷ޹˾
 
<120>  һֿClaudin18.2弰俹ҩż

<130>  2021

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  ˹


<220>
<223>  ɱ

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Tyr Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  113
<212>  PRT
<213>  ˹


<220>
<223>  ɱ

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Ala Tyr Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  3
<211>  7
<212>  PRT
<213>  ˹


<220>
<223>  CDR

<400>  3

Gly Tyr Ala Phe Thr Asn Tyr 
1               5           


<210>  4
<211>  10
<212>  PRT
<213>  ˹


<220>
<223>  CDR

<400>  4

Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Glu 
1               5                   10  


<210>  5
<211>  5
<212>  PRT
<213>  ˹


<220>
<223>  CDR

<400>  5

Asn Tyr Leu Ile Glu 
1               5   


<210>  6
<211>  6
<212>  PRT
<213>  ˹


<220>
<223>  CDR

<400>  6

Thr Asn Tyr Leu Ile Glu 
1               5       


<210>  7
<211>  8
<212>  PRT
<213>  ˹


<220>
<223>  CDR

<400>  7

Gly Tyr Ala Phe Thr Asn Tyr Leu 
1               5               


<210>  8
<211>  6
<212>  PRT
<213>  ˹


<220>
<223>  CDR

<400>  8

Asn Pro Gly Ser Gly Gly 
1               5       


<210>  9
<211>  10
<212>  PRT
<213>  ˹


<220>
<223>  CDR

<400>  9

Leu Ile Asn Pro Gly Ser Gly Gly Thr Asn 
1               5                   10  


<210>  10
<211>  17
<212>  PRT
<213>  ˹


<220>
<223>  CDR

<400>  10

Leu Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  11

Trp Met Gly Leu Ile Asn Pro Gly Ser Gly Gly Thr Asn 
1               5                   10              


<210>  12
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  12

Ile Asn Pro Gly Ser Gly Gly Thr 
1               5               


<210>  13
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  13

Gly Gly Tyr Tyr Gly Asn Ser Phe Ala Tyr 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  14

Gly Gly Tyr Tyr Gly Asn Ser Phe Ala Tyr 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  15

Gly Gly Tyr Tyr Gly Asn Ser Phe Ala Tyr 
1               5                   10  


<210>  16
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  16

Ala Arg Gly Gly Tyr Tyr Gly Asn Ser Phe Ala 
1               5                   10      


<210>  17
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  17

Ala Arg Gly Gly Tyr Tyr Gly Asn Ser Phe Ala Tyr 
1               5                   10          


<210>  18
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  18

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  19
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  19

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  20
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  20

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  21
<211>  13
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  21

Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr 
1               5                   10              


<210>  22
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  22

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  23
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  23

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  24

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  25

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  26
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  26

Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu 
1               5                   10  


<210>  27
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  27

Trp Ala Ser 
1           


<210>  28
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  28

Gln Asn Ala Tyr Tyr Tyr Pro Tyr Thr 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  29

Gln Asn Ala Tyr Tyr Tyr Pro Tyr Thr 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  30

Gln Asn Ala Tyr Tyr Tyr Pro Tyr Thr 
1               5                   


<210>  31
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  31

Gln Asn Ala Tyr Tyr Tyr Pro Tyr 
1               5               


<210>  32
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  CDR

<400>  32

Gln Asn Ala Tyr Tyr Tyr Pro Tyr Thr 
1               5                   


<210>  33
<211>  449
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Tyr Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  34
<211>  220
<212>  PRT
<213>  ˹

<220>
<223>  

<400>  34

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Ala Tyr Tyr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


