                               SEQUENCE LISTING

<110> SENTI BIOSCIENCES, INC.
 
<120> CHIMERIC RECEPTORS AND METHODS OF USE THEREOF

<130> STB-033WO

<140> PCT/US2022/028202
<141> 2022-05-06

<150> 63/283,147
<151> 2021-11-24

<150> 63/185,896
<151> 2021-05-07

<160> 105   

<170> PatentIn version 3.5

<210> 1
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 1
Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 2
Gly Phe Thr Phe Ser Asn Ser 
1               5           


<210> 3
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 3
Ser Asp Gly Gly Leu Tyr 
1               5       


<210> 4
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 4
Gln Gly Val Arg Pro Phe Phe Asp Tyr 
1               5                   


<210> 5
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 5
Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 6
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 6
Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
1               5                   10                  15      


Ala Ser Ile 
            


<210> 7
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 7
Thr His Tyr Pro Asp Ser Val Lys Gly Glu Asp Thr Ala Ile Tyr Tyr 
1               5                   10                  15      


Cys Ala Arg 
            


<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 8
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 9
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Val Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 10
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Leu Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Val Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 11
Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 12
Arg Ala Ser Glu Asn Leu Tyr Ser Tyr Leu Ala 
1               5                   10      


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 13
Asn Ala Glu Thr Leu Pro Glu 
1               5           


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 14
Gln His His Tyr Val Ile Pro Trp Thr 
1               5                   


<210> 15
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 15
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys 
            20              


<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 16
Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Phe 
1               5                   10                  15  


<210> 17
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 17
Gly Val Pro Ser Arg Phe Ser Gly Thr Gly Ser Gly Thr His Phe Ser 
1               5                   10                  15      


Leu Arg Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys 
            20                  25                  30          


<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 18
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210> 19
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 19
Gly Gly Ser 
1           


<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 20
Gly Gly Ser Gly Gly Ser 
1               5       


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 21
Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210> 22
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 22
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210> 23
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 23
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210> 24
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 24
Gly Gly Gly Ser 
1               


<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 25
Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210> 26
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 26
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210> 27
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 27
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210> 28
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 28
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 29
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 29
Gly Gly Gly Gly Ser 
1               5   


<210> 30
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 30
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 31
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 31
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 32
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 32
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 33
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 33
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 34
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 34
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210> 35
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 35
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys 
            20  


<210> 36
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 36
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210> 37
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 37
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
            20                  25          


<210> 38
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 38
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
            20                  25              


<210> 39
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 39
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Leu Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 40
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 40
Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40          


<210> 41
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 41
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 42
Glu Ser Lys Tyr Gly Pro Pro Ala Pro Ser Ala Pro 
1               5                   10          


<210> 43
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 43
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210> 44
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 44
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10          


<210> 45
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 45
Ala Ala Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
1               5                   10                  15      


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            20                  25                  30          


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        35                  40                  45              


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    50                  55                  60                  


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
65                  70                  75                  80  


Tyr Cys Asn His Arg Asn 
                85      


<210> 46
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 46
Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala 
1               5                   10                  15      


Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr 
            20                  25                  30          


Val Cys Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser 
        35                  40                  45              


Ala Thr Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser 
    50                  55                  60                  


Met Ser Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala 
65                  70                  75                  80  


Tyr Gly Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg 
                85                  90                  95      


Val Cys Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln 
            100                 105                 110         


Asn Thr Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala 
        115                 120                 125             


Asp Ala Glu Cys 
    130         


<210> 47
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 47
Ala Cys Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala 
1               5                   10                  15      


Cys Asn Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr 
            20                  25                  30          


Val Cys 
        


<210> 48
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 48
Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
1               5                   10                  15      


Pro Phe Lys Val 
            20  


<210> 49
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 49
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Leu Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 50
<211> 66
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 50
Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe 
1               5                   10                  15      


Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            20                  25                  30          


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        35                  40                  45              


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    50                  55                  60                  


Cys Asp 
65      


<210> 51
<211> 55
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 51
Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Leu Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp 
    50                  55  


<210> 52
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 52
accacaactc ctgctcctag acctcctaca ccagctccta caatcgccct gcagccactg       60

tctctgaggc cagaagcttg tagacctgct gcaggcggag ccgtgcatac aagaggactg      120

gatttcgcct gcgac                                                       135


<210> 53
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 53
gcagcagcta tcgaggtgat gtatcctccg ccctacctgg ataatgaaaa gagtaatggg       60

actatcattc atgtaaaagg gaagcatctt tgtccttctc cccttttccc cggtccgtct      120

aaacct                                                                 126


<210> 54
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 54
gaaagcaagt acggtccacc ttgccctagc tgtccg                                 36


<210> 55
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 55
gaatccaagt acggcccccc agcgcctagt gcccca                                 36


<210> 56
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 56
gaatctaaat atggcccgcc atgcccgcct tgccca                                 36


<210> 57
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 57
gaaccgaagt cttgtgataa aactcatacg tgcccg                                 36


<210> 58
<211> 258
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 58
gctgctgctt tcgtacccgt gttcctccct gctaagccta cgactacccc cgcaccgaga       60

ccacccacgc cagcacccac gattgctagc cagcccctta gtttgcgacc agaagcttgt      120

cggcctgctg ctggtggcgc ggtacatacc cgcggccttg attttgcttg cgatatatat      180

atctgggcgc ctctggccgg aacatgcggg gtcctcctcc tttctctggt tattactctc      240

tactgtaatc acaggaat                                                    258


<210> 59
<211> 396
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 59
gcctgcccga ccgggctcta cactcatagc ggggaatgtt gtaaggcatg taacttgggt       60

gagggcgtcg cacagccctg cggagctaac caaacagtgt gcgaaccctg cctcgatagt      120

gtgacgttct ctgatgttgt atcagctaca gagccttgca aaccatgtac tgagtgcgtt      180

ggacttcagt caatgagcgc tccatgtgtg gaggcagatg atgcggtctg tcgatgtgct      240

tacggatact accaagacga gacaacaggg cggtgcgagg cctgtagagt ttgtgaggcg      300

ggctccgggc tggtgttttc atgtcaagac aagcaaaata cggtctgtga agagtgccct      360

gatggcacct actcagacga agcagatgca gaatgc                                396


<210> 60
<211> 102
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 60
gcctgcccta caggactcta cacgcatagc ggtgagtgtt gtaaagcatg caacctcggg       60

gaaggtgtag cccagccatg cggggctaac caaaccgttt gc                         102


<210> 61
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 61
gctgtgggcc aggacacgca ggaggtcatc gtggtgccac actccttgcc ctttaaggtg       60


<210> 62
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<400> 62
Gly Gly Cys Lys Xaa Ser Gly Gly Cys Lys Xaa Ser 
1               5                   10          


<210> 63
<211> 504
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 63
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Ser Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
                85                  90                  95      


Lys Ser Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Ile Tyr Tyr Cys Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Met Thr 
                165                 170                 175     


Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln 
            180                 185                 190         


Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Phe Asn Ala Glu Thr Leu 
        195                 200                 205             


Pro Glu Gly Val Pro Ser Arg Phe Ser Gly Thr Gly Ser Gly Thr His 
    210                 215                 220                 


Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr 
225                 230                 235                 240 


Tyr Cys Gln His His Tyr Val Ile Pro Trp Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
            260                 265                 270         


Asp Ser Thr Asn Gly Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Leu Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                325                 330                 335     


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            340                 345                 350         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        355                 360                 365             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    370                 375                 380                 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210> 64
<211> 504
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 64
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu 
        35                  40                  45              


Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser 
    50                  55                  60                  


Pro Gln Leu Leu Val Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile 
                85                  90                  95      


Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His 
            100                 105                 110         


Tyr Val Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser Gly 
                165                 170                 175     


Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala 
            180                 185                 190         


Ser Ile Ser Asp Gly Gly Leu Tyr Thr His Tyr Pro Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
                245                 250                 255     


Leu Thr Val Ser Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
            260                 265                 270         


Asp Ser Thr Asn Gly Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Leu Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                325                 330                 335     


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            340                 345                 350         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        355                 360                 365             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    370                 375                 380                 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg 
            500                 


<210> 65
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 65
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Ser Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
                85                  90                  95      


Lys Ser Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Ile Tyr Tyr Cys Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Ser Thr Ser Gly 
    130                 135                 140                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Gln 
145                 150                 155                 160 


Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val 
                165                 170                 175     


Thr Met Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala Trp 
            180                 185                 190         


Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Phe Asn Ala 
        195                 200                 205             


Glu Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly Thr Gly Ser 
    210                 215                 220                 


Gly Thr His Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro Glu Asp Phe 
225                 230                 235                 240 


Gly Ser Tyr Tyr Cys Gln His His Tyr Val Ile Pro Trp Thr Phe Gly 
                245                 250                 255     


Gly Gly Thr Lys Leu Glu Ile Lys Gly Lys Pro Ile Pro Asn Pro Leu 
            260                 265                 270         


Leu Gly Leu Asp Ser Thr Asn Gly Ala Ala Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Leu Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly 
                325                 330                 335     


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            340                 345                 350         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        355                 360                 365             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    370                 375                 380                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
385                 390                 395                 400 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                405                 410                 415     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            420                 425                 430         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        435                 440                 445             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    450                 455                 460                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
465                 470                 475                 480 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                485                 490                 495     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505         


<210> 66
<211> 507
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 66
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu 
        35                  40                  45              


Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser 
    50                  55                  60                  


Pro Gln Leu Leu Val Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile 
                85                  90                  95      


Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His 
            100                 105                 110         


Tyr Val Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
    130                 135                 140                 


Lys Gly Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                165                 170                 175     


Asn Ser Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu 
            180                 185                 190         


Trp Val Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His Tyr Pro Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Ser Thr 
    210                 215                 220                 


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Thr Leu Thr Val Ser Ser Gly Lys Pro Ile Pro Asn Pro Leu 
            260                 265                 270         


Leu Gly Leu Asp Ser Thr Asn Gly Ala Ala Thr Thr Thr Pro Ala Pro 
        275                 280                 285             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Leu Gln Pro Leu Ser Leu 
    290                 295                 300                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
305                 310                 315                 320 


Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly 
                325                 330                 335     


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
            340                 345                 350         


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        355                 360                 365             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    370                 375                 380                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
385                 390                 395                 400 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                405                 410                 415     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            420                 425                 430         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        435                 440                 445             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    450                 455                 460                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
465                 470                 475                 480 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                485                 490                 495     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505         


<210> 67
<211> 494
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 67
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Ser Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
                85                  90                  95      


Lys Ser Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Ile Tyr Tyr Cys Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
                165                 170                 175     


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
            180                 185                 190         


Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Val Ile Pro Trp 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Lys Pro Ile Pro 
                245                 250                 255     


Asn Pro Leu Leu Gly Leu Asp Ser Thr Asn Gly Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Leu Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210> 68
<211> 494
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 68
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu 
        35                  40                  45              


Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser 
    50                  55                  60                  


Pro Gln Leu Leu Val Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile 
                85                  90                  95      


Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His 
            100                 105                 110         


Tyr Val Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu 
    130                 135                 140                 


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Asn Ser Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
                165                 170                 175     


Arg Leu Glu Trp Val Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His 
            180                 185                 190         


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
        195                 200                 205             


Lys Ser Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
    210                 215                 220                 


Ala Ile Tyr Tyr Cys Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Lys Pro Ile Pro 
                245                 250                 255     


Asn Pro Leu Leu Gly Leu Asp Ser Thr Asn Gly Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Leu Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val 
305                 310                 315                 320 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                325                 330                 335     


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210> 69
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 69
Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu 
145                 150                 155                 160 


Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser 
                165                 170                 175     


Pro Gln Leu Leu Val Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile 
        195                 200                 205             


Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His 
    210                 215                 220                 


Tyr Val Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210> 70
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 70
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Val Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Met Val Glu 
        115                 120                 125             


Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Asp Gly 
                165                 170                 175     


Gly Leu Tyr Thr His Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gln Gly Val Arg 
    210                 215                 220                 


Pro Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235                 240 


<210> 71
<211> 243
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 71
Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
        115                 120                 125             


Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln 
                165                 170                 175     


Gly Lys Ser Pro Gln Leu Leu Val Phe Asn Ala Glu Thr Leu Pro Glu 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Thr Gly Ser Gly Thr His Phe Ser 
        195                 200                 205             


Leu Arg Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser Tyr Tyr Cys 
    210                 215                 220                 


Gln His His Tyr Val Ile Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210> 72
<211> 243
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 72
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Val Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Gln 
        115                 120                 125             


Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Ser Leu Lys 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser Gly Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile 
                165                 170                 175     


Ser Asp Gly Gly Leu Tyr Thr His Tyr Pro Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gln 
    210                 215                 220                 


Gly Val Arg Pro Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210> 73
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 73
Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
        115                 120                 125             


Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr Val Thr Met 
    130                 135                 140                 


Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala Trp Tyr Gln 
145                 150                 155                 160 


Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Phe Asn Ala Glu Thr 
                165                 170                 175     


Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly Thr Gly Ser Gly Thr 
            180                 185                 190         


His Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro Glu Asp Phe Gly Ser 
        195                 200                 205             


Tyr Tyr Cys Gln His His Tyr Val Ile Pro Trp Thr Phe Gly Gly Gly 
    210                 215                 220                 


Thr Lys Leu Glu Ile Lys 
225                 230 


<210> 74
<211> 230
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 74
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Val Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
        115                 120                 125             


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
    130                 135                 140                 


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
145                 150                 155                 160 


Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His Tyr Pro Asp Ser Val 
                165                 170                 175     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr 
            180                 185                 190         


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
        195                 200                 205             


Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
    210                 215                 220                 


Thr Leu Thr Val Ser Ser 
225                 230 


<210> 75
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 75
gaggtgcaga tggttgagtc tggcggcgat ctggttaagc ctggcggaag cctgaagctg       60

tcttgtgccg ccagcggctt caccttcagc aatagcggca tgagctgggt ccgacagacc      120

cctgacaaga gactggaatg ggtcgccagc atctctgacg gcggcctgta cacacactac      180

cccgattctg tgaagggcag attcaccatc agcagagaca acggcaagag caccctgtac      240

ctgcagatga gcagcctgag aagcgaggac accgccatct actactgcgc cagacagggc      300

gtcagaccct tcttcgatta ttggggccag ggcaccacac tgaccgtgtc atctggcgga      360

ggcggatcag gtggcggagg aagtggcggc ggaggatctg acatccagat gacacagtct      420

ccagccagcc tgtctgcctc tgtgggagag acagtgacca tgacctgtcg ggccagcgag      480

aacatctaca gctacctggc ctggtatcag cagaagcagg gcaagtctcc tcagctgctg      540

gtgttcaacg ccgagacact gcctgaaggc gtgcccagca gattttctgg aacaggcagc      600

ggcacccact tcagcctgag aatcaatagc ctgcagcctg aggacttcgg cagctactac      660

tgccagcacc actacgtgat cccttggacc tttggcggag gcaccaagct ggaaatcaag      720


<210> 76
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 76
gacatccaga tgacacagtc tccagccagc ctgtctgcct ctgtgggaga gacagtgacc       60

atgacctgtc gggccagcga gaacatctac agctacctgg cctggtatca gcagaagcag      120

ggcaagtctc ctcagctgct ggtgttcaac gccgagacac tgcctgaagg cgtgcccagc      180

agattttctg gaacaggcag cggcacccac ttcagcctga gaatcaatag cctgcagcct      240

gaggacttcg gcagctacta ctgccagcac cactacgtga tcccttggac ctttggcgga      300

ggcaccaagc tggaaatcaa gggcggaggc ggatcaggtg gcggaggaag tggcggcgga      360

ggatctgagg tgcagatggt tgagtctggc ggcgatctgg ttaagcctgg cggaagcctg      420

aagctgtctt gtgccgccag cggcttcacc ttcagcaata gcggcatgag ctgggtccga      480

cagacccctg acaagagact ggaatgggtc gccagcatct ctgacggcgg cctgtacaca      540

cactaccccg attctgtgaa gggcagattc accatcagca gagacaacgg caagagcacc      600

ctgtacctgc agatgagcag cctgagaagc gaggacaccg ccatctacta ctgcgccaga      660

cagggcgtca gacccttctt cgattattgg ggccagggca ccacactgac cgtgtcatct      720


<210> 77
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 77
gaggtgcaga tggttgagtc tggcggcgat ctggttaagc ctggcggaag cctgaagctg       60

tcttgtgccg ccagcggctt caccttcagc aatagcggca tgagctgggt ccgacagacc      120

cctgacaaga gactggaatg ggtcgccagc atctctgacg gcggcctgta cacacactac      180

cccgattctg tgaagggcag attcaccatc agcagagaca acggcaagag caccctgtac      240

ctgcagatga gcagcctgag aagcgaggac accgccatct actactgcgc cagacagggc      300

gtcagaccct tcttcgatta ttggggccag ggcaccacac tgaccgtgtc atctggcagc      360

acaagcggct ctggaaaacc tggatctggc gagggctcta ccaagggcga catccagatg      420

acacagtctc cagccagcct gtctgcctct gtgggagaga cagtgaccat gacctgtcgg      480

gccagcgaga acatctacag ctacctggcc tggtatcagc agaagcaggg caagtctcct      540

cagctgctgg tgttcaacgc cgagacactg cctgaaggcg tgcccagcag attttctgga      600

acaggcagcg gcacccactt cagcctgaga atcaatagcc tgcagcctga ggacttcggc      660

agctactact gccagcacca ctacgtgatc ccttggacct ttggcggagg caccaagctg      720

gaaatcaag                                                              729


<210> 78
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 78
gacatccaga tgacacagtc tccagccagc ctgtctgcct ctgtgggaga gacagtgacc       60

atgacctgtc gggccagcga gaacatctac agctacctgg cctggtatca gcagaagcag      120

ggcaagtctc ctcagctgct ggtgttcaac gccgagacac tgcctgaagg cgtgcccagc      180

agattttctg gaacaggcag cggcacccac ttcagcctga gaatcaatag cctgcagcct      240

gaggacttcg gcagctacta ctgccagcac cactacgtga tcccttggac ctttggcgga      300

ggcaccaagc tggaaatcaa gggcagcaca agcggctctg gaaaacctgg atctggcgag      360

ggctctacca agggcgaggt gcagatggtt gagtctggcg gcgatctggt taagcctggc      420

ggaagcctga agctgtcttg tgccgccagc ggcttcacct tcagcaatag cggcatgagc      480

tgggtccgac agacccctga caagagactg gaatgggtcg ccagcatctc tgacggcggc      540

ctgtacacac actaccccga ttctgtgaag ggcagattca ccatcagcag agacaacggc      600

aagagcaccc tgtacctgca gatgagcagc ctgagaagcg aggacaccgc catctactac      660

tgcgccagac agggcgtcag acccttcttc gattattggg gccagggcac cacactgacc      720

gtgtcatct                                                              729


<210> 79
<211> 690
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 79
gaggtgcaga tggttgagtc tggcggcgat ctggttaagc ctggcggaag cctgaagctg       60

tcttgtgccg ccagcggctt caccttcagc aatagcggca tgagctgggt ccgacagacc      120

cctgacaaga gactggaatg ggtcgccagc atctctgacg gcggcctgta cacacactac      180

cccgattctg tgaagggcag attcaccatc agcagagaca acggcaagag caccctgtac      240

ctgcagatga gcagcctgag aagcgaggac accgccatct actactgcgc cagacagggc      300

gtcagaccct tcttcgatta ttggggccag ggcaccacac tgaccgtgtc atctggtggc      360

ggaggcagcg acatccagat gacacagtct ccagccagcc tgtctgcctc tgtgggagag      420

acagtgacca tgacctgtcg ggccagcgag aacatctaca gctacctggc ctggtatcag      480

cagaagcagg gcaagtctcc tcagctgctg gtgttcaacg ccgagacact gcctgaaggc      540

gtgcccagca gattttctgg aacaggcagc ggcacccact tcagcctgag aatcaatagc      600

ctgcagcctg aggacttcgg cagctactac tgccagcacc actacgtgat cccttggacc      660

tttggcggag gcaccaagct ggaaatcaag                                       690


<210> 80
<211> 690
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 80
gacatccaga tgacacagtc tccagccagc ctgtctgcct ctgtgggaga gacagtgacc       60

atgacctgtc gggccagcga gaacatctac agctacctgg cctggtatca gcagaagcag      120

ggcaagtctc ctcagctgct ggtgttcaac gccgagacac tgcctgaagg cgtgcccagc      180

agattttctg gaacaggcag cggcacccac ttcagcctga gaatcaatag cctgcagcct      240

gaggacttcg gcagctacta ctgccagcac cactacgtga tcccttggac ctttggcgga      300

ggcaccaagc tggaaatcaa gggtggcgga ggcagcgagg tgcagatggt tgagtctggc      360

ggcgatctgg ttaagcctgg cggaagcctg aagctgtctt gtgccgccag cggcttcacc      420

ttcagcaata gcggcatgag ctgggtccga cagacccctg acaagagact ggaatgggtc      480

gccagcatct ctgacggcgg cctgtacaca cactaccccg attctgtgaa gggcagattc      540

accatcagca gagacaacgg caagagcacc ctgtacctgc agatgagcag cctgagaagc      600

gaggacaccg ccatctacta ctgcgccaga cagggcgtca gacccttctt cgattattgg      660

ggccagggca ccacactgac cgtgtcatct                                       690


<210> 81
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 81
gaggtgcaga tggtggaaag cggcggagat ctggtgaagc ctggcggcag cctgaagctg       60

tcttgtgccg cttctggctt taccttcagc aacagcggca tgagctgggt cagacagacc      120

cctgataagc ggctggaatg ggtggccagc atcagcgacg gcggactgta cacccactac      180

ccagacagcg tgaaaggcag attcacaatc agccgggaca acggcaagtc caccctgtat      240

ctgcagatgt ctagcctgag aagcgaggac accgccatct actactgcgc cagacaaggc      300

gtgcgcccct tcttcgacta ctggggccag ggaacaacac tcaccgtgtc ctccggcgga      360

ggcggatcag gtggcggagg aagtggcggc ggaggatctg atatccagat gacccagagc      420

cctgcttctc tgagcgccag cgtgggcgag acagtgacca tgacctgtag agcctccgag      480

aatatctaca gctacctggc ctggtaccag cagaaacagg gcaagagccc ccagctgctg      540

gtctttaacg ccgagacact gcctgaaggc gtgccatcta gattctccgg caccggcagc      600

ggcacacact tcagcctccg gatcaacagc ctgcaacctg aggacttcgg atcttattac      660

tgccagcacc actacgtgat cccctggacc ttcggcggag gcaccaagct ggaaatcaag      720


<210> 82
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 82
gatatccaga tgacccagag ccctgcttct ctgagcgcca gcgtgggcga gacagtgacc       60

atgacctgta gagcctccga gaatatctac agctacctgg cctggtacca gcagaaacag      120

ggcaagagcc cccagctgct ggtctttaac gccgagacac tgcctgaagg cgtgccatct      180

agattctccg gcaccggcag cggcacacac ttcagcctcc ggatcaacag cctgcaacct      240

gaggacttcg gatcttatta ctgccagcac cactacgtga tcccctggac cttcggcgga      300

ggcaccaagc tggaaatcaa gggcggaggc ggatcaggtg gcggaggaag tggcggcgga      360

ggatctgagg tgcagatggt ggaaagcggc ggagatctgg tgaagcctgg cggcagcctg      420

aagctgtctt gtgccgcttc tggctttacc ttcagcaaca gcggcatgag ctgggtcaga      480

cagacccctg ataagcggct ggaatgggtg gccagcatca gcgacggcgg actgtacacc      540

cactacccag acagcgtgaa aggcagattc acaatcagcc gggacaacgg caagtccacc      600

ctgtatctgc agatgtctag cctgagaagc gaggacaccg ccatctacta ctgcgccaga      660

caaggcgtgc gccccttctt cgactactgg ggccagggaa caacactcac cgtgtcctcc      720


<210> 83
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 83
gaggtgcaga tggtggaaag cggcggagat ctggtgaagc ctggcggcag cctgaagctg       60

tcttgtgccg cttctggctt taccttcagc aacagcggca tgagctgggt cagacagacc      120

cctgataagc ggctggaatg ggtggccagc atcagcgacg gcggactgta cacccactac      180

ccagacagcg tgaaaggcag attcacaatc agccgggaca acggcaagtc caccctgtat      240

ctgcagatgt ctagcctgag aagcgaggac accgccatct actactgcgc cagacaaggc      300

gtgcgcccct tcttcgacta ctggggccag ggaacaacac tcaccgtgtc ctccggcagc      360

acaagcggct ctggaaaacc tggatctggc gagggctcta ccaagggcga tatccagatg      420

acccagagcc ctgcttctct gagcgccagc gtgggcgaga cagtgaccat gacctgtaga      480

gcctccgaga atatctacag ctacctggcc tggtaccagc agaaacaggg caagagcccc      540

cagctgctgg tctttaacgc cgagacactg cctgaaggcg tgccatctag attctccggc      600

accggcagcg gcacacactt cagcctccgg atcaacagcc tgcaacctga ggacttcgga      660

tcttattact gccagcacca ctacgtgatc ccctggacct tcggcggagg caccaagctg      720

gaaatcaag                                                              729


<210> 84
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 84
gatatccaga tgacccagag ccctgcttct ctgagcgcca gcgtgggcga gacagtgacc       60

atgacctgta gagcctccga gaatatctac agctacctgg cctggtacca gcagaaacag      120

ggcaagagcc cccagctgct ggtctttaac gccgagacac tgcctgaagg cgtgccatct      180

agattctccg gcaccggcag cggcacacac ttcagcctcc ggatcaacag cctgcaacct      240

gaggacttcg gatcttatta ctgccagcac cactacgtga tcccctggac cttcggcgga      300

ggcaccaagc tggaaatcaa gggcagcaca agcggctctg gaaaacctgg atctggcgag      360

ggctctacca agggcgaggt gcagatggtg gaaagcggcg gagatctggt gaagcctggc      420

ggcagcctga agctgtcttg tgccgcttct ggctttacct tcagcaacag cggcatgagc      480

tgggtcagac agacccctga taagcggctg gaatgggtgg ccagcatcag cgacggcgga      540

ctgtacaccc actacccaga cagcgtgaaa ggcagattca caatcagccg ggacaacggc      600

aagtccaccc tgtatctgca gatgtctagc ctgagaagcg aggacaccgc catctactac      660

tgcgccagac aaggcgtgcg ccccttcttc gactactggg gccagggaac aacactcacc      720

gtgtcctcc                                                              729


<210> 85
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 85
ggaggcggag gatctggtgg cggaggaagt ggcggaggcg gttct                       45


<210> 86
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 86
ggtggtggtg gcagtggtgg cggtggctca ggtggcggcg gatcaggcgg tggtggttct       60

ggcggcggtg gatct                                                        75


<210> 87
<211> 243
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 87
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Val Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Gln 
        115                 120                 125             


Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Ser Leu Lys 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser Gly Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile 
                165                 170                 175     


Ser Asp Gly Gly Leu Tyr Thr His Tyr Pro Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gln 
    210                 215                 220                 


Gly Val Arg Pro Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210> 88
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 88
Ile Leu Ile Gly Val Ser Val Val Phe Leu Phe Cys Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Phe Cys Leu 
            20      


<210> 89
<211> 101
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 89
His Arg Gln Asn Gln Ile Lys Gln Gly Pro Pro Arg Ser Lys Asp Glu 
1               5                   10                  15      


Glu Gln Lys Pro Gln Gln Arg Pro Asp Leu Ala Val Asp Val Leu Glu 
            20                  25                  30          


Arg Thr Ala Asp Lys Ala Thr Val Asn Gly Leu Pro Glu Lys Asp Arg 
        35                  40                  45              


Glu Thr Asp Thr Ser Ala Leu Ala Ala Gly Ser Ser Gln Glu Val Thr 
    50                  55                  60                  


Tyr Ala Gln Leu Asp His Trp Ala Leu Thr Gln Arg Thr Ala Arg Ala 
65                  70                  75                  80  


Val Ser Pro Gln Ser Thr Lys Pro Met Ala Glu Ser Ile Thr Tyr Ala 
                85                  90                  95      


Ala Val Ala Arg His 
            100     


<210> 90
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 90
Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Phe Leu Ile 
            20      


<210> 91
<211> 168
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 91
Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys 
1               5                   10                  15      


Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp 
            20                  25                  30          


Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu 
        35                  40                  45              


Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
    50                  55                  60                  


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
65                  70                  75                  80  


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
                85                  90                  95      


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
            100                 105                 110         


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
        115                 120                 125             


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
    130                 135                 140                 


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
145                 150                 155                 160 


Ile Tyr Ala Thr Leu Ala Ile His 
                165             


<210> 92
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 92
Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu Phe 
1               5                   10                  15      


Phe Leu Leu 
            


<210> 93
<211> 84
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 93
His Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu 
1               5                   10                  15      


Ser Ala Gly Asn Arg Thr Ala Asn Ser Glu Asp Ser Asp Glu Gln Asp 
            20                  25                  30          


Pro Gln Glu Val Thr Tyr Thr Gln Leu Asn His Cys Val Phe Thr Gln 
        35                  40                  45              


Arg Lys Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp 
    50                  55                  60                  


Ile Ile Val Tyr Thr Glu Leu Pro Asn Ala Glu Ser Arg Ser Lys Val 
65                  70                  75                  80  


Val Ser Cys Pro 
                


<210> 94
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 94
Val Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile 
1               5                   10                  15      


Cys Gly Leu 
            


<210> 95
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 95
Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu Gln 
1               5                   10                  15      


Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val Arg 
            20                  25                  30          


Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn Pro 
        35                  40                  45              


Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu Met 
    50                  55                  60                  


Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg Pro 
65                  70                  75                  80  


Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys Arg 
                85                  90                  95      


Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp Glu 
            100                 105                 110         


Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg Pro 
        115                 120                 125             


Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
    130                 135                 140     


<210> 96
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 96
Ile Val Val Gly Val Val Cys Thr Leu Leu Val Ala Leu Leu Met Ala 
1               5                   10                  15      


Ala Leu Tyr Leu 
            20  


<210> 97
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 97
Val Arg Ile Arg Gln Lys Lys Ala Gln Gly Ser Thr Ser Ser Thr Arg 
1               5                   10                  15      


Leu His Glu Pro Glu Lys Asn Ala Arg Glu Ile Thr Gln Asp Thr Asn 
            20                  25                  30          


Asp Ile Thr Tyr Ala Asp Leu Asn Leu Pro Lys Gly Lys Lys Pro Ala 
        35                  40                  45              


Pro Gln Ala Ala Glu Pro Asn Asn His Thr Glu Tyr Ala Ser Ile Gln 
    50                  55                  60                  


Thr Ser Pro Gln Pro Ala Ser Glu Asp Thr Leu Thr Tyr Ala Asp Leu 
65                  70                  75                  80  


Asp Met Val His Leu Asn Arg Thr Pro Lys Gln Pro Ala Pro Lys Pro 
                85                  90                  95      


Glu Pro Ser Phe Ser Glu Tyr Ala Ser Val Gln Val Pro Arg Lys 
            100                 105                 110     


<210> 98
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 98
Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu Leu 
1               5                   10                  15      


Phe Phe Leu Leu 
            20  


<210> 99
<211> 84
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 99
His Leu Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu 
1               5                   10                  15      


Pro Ala Gly Asn Arg Thr Ala Asn Ser Glu Asp Ser Asp Glu Gln Asp 
            20                  25                  30          


Pro Glu Glu Val Thr Tyr Ala Gln Leu Asp His Cys Val Phe Thr Gln 
        35                  40                  45              


Arg Lys Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp 
    50                  55                  60                  


Thr Ile Leu Tyr Thr Glu Leu Pro Asn Ala Lys Pro Arg Ser Lys Val 
65                  70                  75                  80  


Val Ser Cys Pro 
                


<210> 100
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 100
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Leu Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210> 101
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide


<220>
<221> SITE
<222> (1)..(30)
<223> This sequence may encompass 1-6 'Gly Gly Gly Gly Ser' 
      repeating units

<400> 101
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 102
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 102
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 103
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 103
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Asn Ala Glu Thr Leu Pro Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr His Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Val Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 104
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 104
Glu Val Gln Met Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Asp Gly Gly Leu Tyr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Val Arg Pro Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210> 105
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic peptide

<400> 105
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  



