                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  T CELL RECEPTORS RECOGNIZING C135Y, R175H, OR M237I MUTATION IN 
       P53

<130>  759875

<150>  US 63/185,805
<151>  2021-05-07

<160>  97    

<170>  PatentIn version 3.5

<210>  1
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  2
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Thr Leu Ser Asn 
1               5   


<210>  3
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Val Lys Ser Gly Glu Val 
1               5           


<210>  4
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Ala Glu Ser Tyr Ser Gly Gly Tyr Gln Lys Val Thr Phe 
1               5                   10                  


<210>  5
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Ser Asn His Leu Tyr 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Phe Tyr Asn Asn Glu Ile 
1               5       


<210>  7
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Ala Ser Ser Ser Phe Ser Asn Glu Gln Phe Phe 
1               5                   10          


<210>  8
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln Glu Gly Glu 
1               5                   10                  15      


Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser Asn Ile Gln 
            20                  25                  30          


Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu Ile Gln Leu 
        35                  40                  45              


Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr Phe Gln Phe 
    50                  55                  60                  


Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala Thr Gln Thr 
65                  70                  75                  80  


Thr Asp Val Gly Thr Tyr Phe Cys Ala Glu Ser Tyr Ser Gly Gly Tyr 
                85                  90                  95      


Gln Lys Val Thr Phe Gly Ile Gly Thr Lys Leu Gln Val Ile Pro 
            100                 105                 110     


<210>  9
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Ser 
                85                  90                  95      


Phe Ser Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110         


<210>  10
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met His Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      


Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          


Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              


Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  


Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Glu Ser Tyr Ser 
            100                 105                 110         


Gly Gly Tyr Gln Lys Val Thr Phe Gly Ile Gly Thr Lys Leu Gln Val 
        115                 120                 125             


Ile Pro 
    130 


<210>  11
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Ala Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Ser Phe Ser Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu 
    130     


<210>  12
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met His Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      


Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          


Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              


Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  


Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Glu Ser Tyr Ser 
            100                 105                 110         


Gly Gly Tyr Gln Lys Val Thr Phe Gly Ile Gly Thr Lys Leu Gln Val 
        115                 120                 125             


Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  13
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Ala Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Ser Phe Ser Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  14
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln Glu Gly Glu 
1               5                   10                  15      


Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser Asn Ile Gln 
            20                  25                  30          


Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu Ile Gln Leu 
        35                  40                  45              


Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr Phe Gln Phe 
    50                  55                  60                  


Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala Thr Gln Thr 
65                  70                  75                  80  


Thr Asp Val Gly Thr Tyr Phe Cys Ala Glu Ser Tyr Ser Gly Gly Tyr 
                85                  90                  95      


Gln Lys Val Thr Phe Gly Ile Gly Thr Lys Leu Gln Val Ile Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
        115                 120                 125             


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
    130                 135                 140                 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val 
145                 150                 155                 160 


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
                165                 170                 175     


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
            180                 185                 190         


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
        195                 200                 205             


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val 
    210                 215                 220                 


Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
225                 230                 235                 240 


Met Thr Leu Arg Leu Trp Ser Ser 
                245             


<210>  15
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Ser 
                85                  90                  95      


Phe Ser Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        115                 120                 125             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                165                 170                 175     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            180                 185                 190         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        195                 200                 205             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    210                 215                 220                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
225                 230                 235                 240 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                245                 250                 255     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            260                 265                 270         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285 


<210>  16
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Ala Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Ser Phe Ser Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
305                 310                 315                 320 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Ile Thr 
                325                 330                 335     


Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln Val Asn Gly Gln Gln 
            340                 345                 350         


Val Met Gln Ile Pro Gln Tyr Gln His Val Gln Glu Gly Glu Asp Phe 
        355                 360                 365             


Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser Asn Ile Gln Trp Tyr 
    370                 375                 380                 


Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu Ile Gln Leu Val Lys 
385                 390                 395                 400 


Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr Phe Gln Phe Gly Glu 
                405                 410                 415     


Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala Thr Gln Thr Thr Asp 
            420                 425                 430         


Val Gly Thr Tyr Phe Cys Ala Glu Ser Tyr Ser Gly Gly Tyr Gln Lys 
        435                 440                 445             


Val Thr Phe Gly Ile Gly Thr Lys Leu Gln Val Ile Pro Asn Ile Gln 
    450                 455                 460                 


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
465                 470                 475                 480 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
                485                 490                 495     


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
            500                 505                 510         


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
        515                 520                 525             


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
    530                 535                 540                 


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
545                 550                 555                 560 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
                565                 570                 575     


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            580                 585                 590         


Leu Arg Leu Trp Ser Ser 
        595             


<210>  17
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Ser Glu Asn Asn Tyr Tyr 
1               5           


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Glu Ala Tyr Lys Gln Gln Asn 
1               5               


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  19

Cys Ala Phe Met Ala Tyr Met Glu Tyr Gly Asn Lys Leu Val Phe 
1               5                   10                  15  


<210>  20
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Asn His Leu Tyr 
1               5   


<210>  21
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  21

Phe Tyr Asn Asn Glu Ile 
1               5       


<210>  22
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  22

Cys Ala Cys Lys Gly Ile Thr Asp Thr Gln Tyr Phe 
1               5                   10          


<210>  23
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser Val Gln Glu Ala Glu 
1               5                   10                  15      


Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser Glu Asn Asn Tyr Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln Met Ile Leu Val Ile 
        35                  40                  45              


Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr Glu Asn Arg Phe Ser 
    50                  55                  60                  


Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser Leu Lys Ile Ser Asp 
65                  70                  75                  80  


Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys Ala Phe Met Ala Tyr 
                85                  90                  95      


Met Glu Tyr Gly Asn Lys Leu Val Phe Gly Ala Gly Thr Ile Leu Arg 
            100                 105                 110         


Val Lys Ser 
        115 


<210>  24
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Cys Lys Gly 
                85                  90                  95      


Ile Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110         


<210>  25
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Met His Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu 
1               5                   10                  15      


Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Asn Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Phe Met Ala Tyr Met Glu Tyr Gly Asn Lys Leu Val Phe Gly Ala 
        115                 120                 125             


Gly Thr Ile Leu Arg Val Lys Ser 
    130                 135     


<210>  26
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Met Ala Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Cys Lys Gly Ile Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu 
    130     


<210>  27
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Met His Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu 
1               5                   10                  15      


Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Asn Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Phe Met Ala Tyr Met Glu Tyr Gly Asn Lys Leu Val Phe Gly Ala 
        115                 120                 125             


Gly Thr Ile Leu Arg Val Lys Ser Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  28
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Met Ala Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Cys Lys Gly Ile Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  29
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser Val Gln Glu Ala Glu 
1               5                   10                  15      


Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser Glu Asn Asn Tyr Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln Met Ile Leu Val Ile 
        35                  40                  45              


Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr Glu Asn Arg Phe Ser 
    50                  55                  60                  


Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser Leu Lys Ile Ser Asp 
65                  70                  75                  80  


Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys Ala Phe Met Ala Tyr 
                85                  90                  95      


Met Glu Tyr Gly Asn Lys Leu Val Phe Gly Ala Gly Thr Ile Leu Arg 
            100                 105                 110         


Val Lys Ser Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
        115                 120                 125             


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
    130                 135                 140                 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
145                 150                 155                 160 


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
                165                 170                 175     


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
            180                 185                 190         


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
        195                 200                 205             


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
    210                 215                 220                 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
225                 230                 235                 240 


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250         


<210>  30
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Cys Lys Gly 
                85                  90                  95      


Ile Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        115                 120                 125             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                165                 170                 175     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            180                 185                 190         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        195                 200                 205             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    210                 215                 220                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
225                 230                 235                 240 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                245                 250                 255     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            260                 265                 270         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285 


<210>  31
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Met Ala Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Cys Lys Gly Ile Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
305                 310                 315                 320 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Arg Val Ser 
                325                 330                 335     


Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu Glu Ser Gly Met Ala 
            340                 345                 350         


Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser Val Gln Glu Ala Glu 
        355                 360                 365             


Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser Glu Asn Asn Tyr Tyr 
    370                 375                 380                 


Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln Met Ile Leu Val Ile 
385                 390                 395                 400 


Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr Glu Asn Arg Phe Ser 
                405                 410                 415     


Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser Leu Lys Ile Ser Asp 
            420                 425                 430         


Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys Ala Phe Met Ala Tyr 
        435                 440                 445             


Met Glu Tyr Gly Asn Lys Leu Val Phe Gly Ala Gly Thr Ile Leu Arg 
    450                 455                 460                 


Val Lys Ser Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
465                 470                 475                 480 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
                485                 490                 495     


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
            500                 505                 510         


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
        515                 520                 525             


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
    530                 535                 540                 


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
545                 550                 555                 560 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
                565                 570                 575     


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
            580                 585                 590         


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 


<210>  32
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  32

Tyr Gly Gly Thr Val Asn 
1               5       


<210>  33
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  33

Tyr Phe Ser Gly Asp Pro Leu Val 
1               5               


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  34

Cys Ala Val Thr Phe Met Asp Thr Gly Arg Arg Ala Leu Thr Phe 
1               5                   10                  15  


<210>  35
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Gly His Thr Ala 
1               5   


<210>  36
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  36

Phe Gln Gly Asn Ser Ala 
1               5       


<210>  37
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  37

Cys Ala Ser Ser Pro Arg Gly Gly Asp Tyr Glu Gln Tyr Phe 
1               5                   10                  


<210>  38
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Ser Val Ser Gln His Asn His His Val Ile Leu Ser Glu Ala Ala 
1               5                   10                  15      


Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly Thr Val Asn Leu 
            20                  25                  30          


Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln Leu Leu Leu Lys 
        35                  40                  45              


Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys Gly Phe Glu Ala 
    50                  55                  60                  


Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg Lys Pro Ser Val 
65                  70                  75                  80  


Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val Thr Phe Met Asp 
                85                  90                  95      


Thr Gly Arg Arg Ala Leu Thr Phe Gly Ser Gly Thr Arg Leu Gln Val 
            100                 105                 110         


Gln Pro 
        


<210>  39
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Asp 
1               5                   10                  15      


Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe Leu Ile Tyr Phe Gln 
        35                  40                  45              


Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro Ser Asp Arg Phe Ser 
    50                  55                  60                  


Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu Thr Ile Gln Arg Thr 
65                  70                  75                  80  


Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Pro Arg Gly 
                85                  90                  95      


Gly Asp Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr 
            100                 105                 110         


<210>  40
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg 
1               5                   10                  15      


Asp Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu 
            20                  25                  30          


Ser Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly 
        35                  40                  45              


Thr Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Thr Phe Met Asp Thr Gly Arg Arg Ala Leu Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Gln Pro 
    130                 


<210>  41
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Met Ala Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Arg Gly Gly Asp Tyr Glu Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Thr 
    130             


<210>  42
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg 
1               5                   10                  15      


Asp Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu 
            20                  25                  30          


Ser Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly 
        35                  40                  45              


Thr Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Thr Phe Met Asp Thr Gly Arg Arg Ala Leu Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  43
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Met Ala Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Arg Gly Gly Asp Tyr Glu Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  44
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Gln Ser Val Ser Gln His Asn His His Val Ile Leu Ser Glu Ala Ala 
1               5                   10                  15      


Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly Thr Val Asn Leu 
            20                  25                  30          


Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln Leu Leu Leu Lys 
        35                  40                  45              


Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys Gly Phe Glu Ala 
    50                  55                  60                  


Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg Lys Pro Ser Val 
65                  70                  75                  80  


Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val Thr Phe Met Asp 
                85                  90                  95      


Thr Gly Arg Arg Ala Leu Thr Phe Gly Ser Gly Thr Arg Leu Gln Val 
            100                 105                 110         


Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
        115                 120                 125             


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
    130                 135                 140                 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
145                 150                 155                 160 


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
                165                 170                 175     


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
            180                 185                 190         


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
        195                 200                 205             


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
    210                 215                 220                 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
225                 230                 235                 240 


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250     


<210>  45
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Asp 
1               5                   10                  15      


Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe Leu Ile Tyr Phe Gln 
        35                  40                  45              


Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro Ser Asp Arg Phe Ser 
    50                  55                  60                  


Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu Thr Ile Gln Arg Thr 
65                  70                  75                  80  


Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Pro Arg Gly 
                85                  90                  95      


Gly Asp Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr 
            100                 105                 110         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        115                 120                 125             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                165                 170                 175     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            180                 185                 190         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        195                 200                 205             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    210                 215                 220                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
225                 230                 235                 240 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                245                 250                 255     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            260                 265                 270         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285 


<210>  46
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Met Ala Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Arg Gly Gly Asp Tyr Glu Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
305                 310                 315                 320 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu 
                325                 330                 335     


Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg Asp Ala Arg 
            340                 345                 350         


Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu Ser Glu Ala 
        355                 360                 365             


Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly Thr Val Asn 
    370                 375                 380                 


Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln Leu Leu Leu 
385                 390                 395                 400 


Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys Gly Phe Glu 
                405                 410                 415     


Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg Lys Pro Ser 
            420                 425                 430         


Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val Thr Phe Met 
        435                 440                 445             


Asp Thr Gly Arg Arg Ala Leu Thr Phe Gly Ser Gly Thr Arg Leu Gln 
    450                 455                 460                 


Val Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
465                 470                 475                 480 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
                485                 490                 495     


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
            500                 505                 510         


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
        515                 520                 525             


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
    530                 535                 540                 


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
545                 550                 555                 560 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
                565                 570                 575     


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
            580                 585                 590         


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 


<210>  47
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  47

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  48
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  48

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  49
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  49

Cys Ala Val Arg Gly Gly Asn Thr Gly Phe Gln Lys Leu Val Phe 
1               5                   10                  15  


<210>  50
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  50

Ser Gln Val Thr Met 
1               5   


<210>  51
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  51

Ala Asn Gln Gly Ser Glu Ala 
1               5           


<210>  52
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  52

Cys Ser Val Arg Ser Glu Asp Thr Gln Tyr Phe 
1               5                   10      


<210>  53
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  53

Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu 
1               5                   10                  15      


Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln 
            20                  25                  30          


Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile 
        35                  40                  45              


Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala 
    50                  55                  60                  


Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser 
65                  70                  75                  80  


Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg Gly Gly Asn 
                85                  90                  95      


Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu Leu Val 
            100                 105                 110         


Ser Pro 
        


<210>  54
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  54

Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Cys Gln Arg Gly Thr 
1               5                   10                  15      


Ser Leu Thr Ile Gln Cys Gln Val Asp Ser Gln Val Thr Met Met Phe 
            20                  25                  30          


Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr Ala 
        35                  40                  45              


Asn Gln Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp Lys 
    50                  55                  60                  


Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val Ser 
65                  70                  75                  80  


Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Arg Ser 
                85                  90                  95      


Glu Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  55
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Arg Gly Gly Asn Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Ser Pro 
    130                 


<210>  56
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Met Ala Ser Leu Leu Leu Leu Leu Leu Gly Leu Gly Ser Val Phe Ser 
1               5                   10                  15      


Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Cys Gln Arg Gly Thr 
            20                  25                  30          


Ser Leu Thr Ile Gln Cys Gln Val Asp Ser Gln Val Thr Met Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr Ala 
    50                  55                  60                  


Asn Gln Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp Lys 
65                  70                  75                  80  


Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val Ser 
                85                  90                  95      


Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Arg Ser 
            100                 105                 110         


Glu Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
        115                 120                 125         


<210>  57
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Arg Gly Gly Asn Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr 
        115                 120                 125             


Arg Leu Leu Val Ser Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  58
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Met Ala Ser Leu Leu Leu Leu Leu Leu Gly Leu Gly Ser Val Phe Ser 
1               5                   10                  15      


Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Cys Gln Arg Gly Thr 
            20                  25                  30          


Ser Leu Thr Ile Gln Cys Gln Val Asp Ser Gln Val Thr Met Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr Ala 
    50                  55                  60                  


Asn Gln Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp Lys 
65                  70                  75                  80  


Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val Ser 
                85                  90                  95      


Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Arg Ser 
            100                 105                 110         


Glu Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
        115                 120                 125             


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
    130                 135                 140                 


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
145                 150                 155                 160 


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
                165                 170                 175     


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
            180                 185                 190         


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
        195                 200                 205             


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
    210                 215                 220                 


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
225                 230                 235                 240 


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
                245                 250                 255     


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
            260                 265                 270         


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
        275                 280                 285             


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300 


<210>  59
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu 
1               5                   10                  15      


Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln 
            20                  25                  30          


Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile 
        35                  40                  45              


Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala 
    50                  55                  60                  


Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser 
65                  70                  75                  80  


Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg Gly Gly Asn 
                85                  90                  95      


Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu Leu Val 
            100                 105                 110         


Ser Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
        115                 120                 125             


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
    130                 135                 140                 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
145                 150                 155                 160 


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
                165                 170                 175     


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
            180                 185                 190         


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
        195                 200                 205             


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
    210                 215                 220                 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
225                 230                 235                 240 


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250     


<210>  60
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Cys Gln Arg Gly Thr 
1               5                   10                  15      


Ser Leu Thr Ile Gln Cys Gln Val Asp Ser Gln Val Thr Met Met Phe 
            20                  25                  30          


Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr Ala 
        35                  40                  45              


Asn Gln Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp Lys 
    50                  55                  60                  


Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val Ser 
65                  70                  75                  80  


Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Arg Ser 
                85                  90                  95      


Glu Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
            100                 105                 110         


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
        115                 120                 125             


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
    130                 135                 140                 


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
145                 150                 155                 160 


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
                165                 170                 175     


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
            180                 185                 190         


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
        195                 200                 205             


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
    210                 215                 220                 


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
225                 230                 235                 240 


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
                245                 250                 255     


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
            260                 265                 270         


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 


<210>  61
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Met Ala Ser Leu Leu Leu Leu Leu Leu Gly Leu Gly Ser Val Phe Ser 
1               5                   10                  15      


Ala Val Ile Ser Gln Lys Pro Ser Arg Asp Ile Cys Gln Arg Gly Thr 
            20                  25                  30          


Ser Leu Thr Ile Gln Cys Gln Val Asp Ser Gln Val Thr Met Met Phe 
        35                  40                  45              


Trp Tyr Arg Gln Gln Pro Gly Gln Ser Leu Thr Leu Ile Ala Thr Ala 
    50                  55                  60                  


Asn Gln Gly Ser Glu Ala Thr Tyr Glu Ser Gly Phe Val Ile Asp Lys 
65                  70                  75                  80  


Phe Pro Ile Ser Arg Pro Asn Leu Thr Phe Ser Thr Leu Thr Val Ser 
                85                  90                  95      


Asn Met Ser Pro Glu Asp Ser Ser Ile Tyr Leu Cys Ser Val Arg Ser 
            100                 105                 110         


Glu Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
        115                 120                 125             


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
    130                 135                 140                 


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
145                 150                 155                 160 


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
                165                 170                 175     


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
            180                 185                 190         


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
        195                 200                 205             


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
    210                 215                 220                 


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
225                 230                 235                 240 


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
                245                 250                 255     


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
            260                 265                 270         


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
        275                 280                 285             


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala Lys Arg 
    290                 295                 300                 


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
305                 310                 315                 320 


Val Glu Glu Asn Pro Gly Pro Met Lys Ser Leu Arg Val Leu Leu Val 
                325                 330                 335     


Ile Leu Trp Leu Gln Leu Ser Trp Val Trp Ser Gln Gln Lys Glu Val 
            340                 345                 350         


Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser 
        355                 360                 365             


Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr 
    370                 375                 380                 


Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met Phe Ile Tyr Ser 
385                 390                 395                 400 


Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala 
                405                 410                 415     


Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser 
            420                 425                 430         


Ala Thr Tyr Leu Cys Ala Val Arg Gly Gly Asn Thr Gly Phe Gln Lys 
        435                 440                 445             


Leu Val Phe Gly Thr Gly Thr Arg Leu Leu Val Ser Pro Asn Ile Gln 
    450                 455                 460                 


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
465                 470                 475                 480 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
                485                 490                 495     


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
            500                 505                 510         


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
        515                 520                 525             


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
    530                 535                 540                 


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
545                 550                 555                 560 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
                565                 570                 575     


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            580                 585                 590         


Leu Arg Leu Trp Ser Ser 
        595             


<210>  62
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  62

Val Ser Asn Ala Tyr Asn 
1               5       


<210>  63
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Ser Lys Pro 
1               


<210>  64
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  64

Cys Ala Val Ser Gly Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu 
1               5                   10                  15      


<210>  65
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  65

Ser Gly His Ala Thr 
1               5   


<210>  66
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  66

Phe Gln Asn Asn Gly Val 
1               5       


<210>  67
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  67

Cys Ala Ser Ser Leu Asp Arg Arg Gly Gly Arg Glu Thr Gln Tyr Phe 
1               5                   10                  15      


<210>  68
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  68

Lys Asp Gln Val Phe Gln Pro Ser Thr Val Ala Ser Ser Glu Gly Ala 
1               5                   10                  15      


Val Val Glu Ile Phe Cys Asn His Ser Val Ser Asn Ala Tyr Asn Phe 
            20                  25                  30          


Phe Trp Tyr Leu His Phe Pro Gly Cys Ala Pro Arg Leu Leu Val Lys 
        35                  40                  45              


Gly Ser Lys Pro Ser Gln Gln Gly Arg Tyr Asn Met Thr Tyr Glu Arg 
    50                  55                  60                  


Phe Ser Ser Ser Leu Leu Ile Leu Gln Val Arg Glu Ala Asp Ala Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Val Ser Gly Tyr Gln Leu Ile Trp Gly Ala Gly 
                85                  90                  95      


Thr Lys Leu Ile Ile Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
            100                 105                 110         


<210>  69
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  69

Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile Glu Lys Arg Gln Ser 
1               5                   10                  15      


Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His Ala Thr Leu Tyr Trp 
            20                  25                  30          


Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu Leu Ile Gln Phe Gln 
        35                  40                  45              


Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro Lys Asp Arg Phe Ser 
    50                  55                  60                  


Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu Lys Ile Gln Pro Ala 
65                  70                  75                  80  


Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu Asp Arg 
                85                  90                  95      


Arg Gly Gly Arg Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu 
            100                 105                 110         


Val Leu 
        


<210>  70
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Met His Leu Gln Ser Thr Leu Gly Ala Val Trp Leu Gly Leu Leu Leu 
1               5                   10                  15      


Asn Ser Leu Trp Lys Val Ala Glu Ser Lys Asp Gln Val Phe Gln Pro 
            20                  25                  30          


Ser Thr Val Ala Ser Ser Glu Gly Ala Val Val Glu Ile Phe Cys Asn 
        35                  40                  45              


His Ser Val Ser Asn Ala Tyr Asn Phe Phe Trp Tyr Leu His Phe Pro 
    50                  55                  60                  


Gly Cys Ala Pro Arg Leu Leu Val Lys Gly Ser Lys Pro Ser Gln Gln 
65                  70                  75                  80  


Gly Arg Tyr Asn Met Thr Tyr Glu Arg Phe Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Leu Gln Val Arg Glu Ala Asp Ala Ala Val Tyr Tyr Cys Ala Val Ser 
            100                 105                 110         


Gly Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135         


<210>  71
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Asp Arg Arg Gly Gly Arg Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu 
    130                 135 


<210>  72
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Met His Leu Gln Ser Thr Leu Gly Ala Val Trp Leu Gly Leu Leu Leu 
1               5                   10                  15      


Asn Ser Leu Trp Lys Val Ala Glu Ser Lys Asp Gln Val Phe Gln Pro 
            20                  25                  30          


Ser Thr Val Ala Ser Ser Glu Gly Ala Val Val Glu Ile Phe Cys Asn 
        35                  40                  45              


His Ser Val Ser Asn Ala Tyr Asn Phe Phe Trp Tyr Leu His Phe Pro 
    50                  55                  60                  


Gly Cys Ala Pro Arg Leu Leu Val Lys Gly Ser Lys Pro Ser Gln Gln 
65                  70                  75                  80  


Gly Arg Tyr Asn Met Thr Tyr Glu Arg Phe Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Leu Gln Val Arg Glu Ala Asp Ala Ala Val Tyr Tyr Cys Ala Val Ser 
            100                 105                 110         


Gly Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Glu Pro Ala Val Asn Ile Gln Asn Pro Glu Pro 
    130                 135                 140                 


Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys 
145                 150                 155                 160 


Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu 
                165                 170                 175     


Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met 
            180                 185                 190         


Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe 
        195                 200                 205             


Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser 
    210                 215                 220                 


Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  73
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Asp Arg Arg Gly Gly Arg Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser 
305             


<210>  74
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Lys Asp Gln Val Phe Gln Pro Ser Thr Val Ala Ser Ser Glu Gly Ala 
1               5                   10                  15      


Val Val Glu Ile Phe Cys Asn His Ser Val Ser Asn Ala Tyr Asn Phe 
            20                  25                  30          


Phe Trp Tyr Leu His Phe Pro Gly Cys Ala Pro Arg Leu Leu Val Lys 
        35                  40                  45              


Gly Ser Lys Pro Ser Gln Gln Gly Arg Tyr Asn Met Thr Tyr Glu Arg 
    50                  55                  60                  


Phe Ser Ser Ser Leu Leu Ile Leu Gln Val Arg Glu Ala Asp Ala Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Val Ser Gly Tyr Gln Leu Ile Trp Gly Ala Gly 
                85                  90                  95      


Thr Lys Leu Ile Ile Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
            100                 105                 110         


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
        115                 120                 125             


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
    130                 135                 140                 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
145                 150                 155                 160 


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
                165                 170                 175     


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
            180                 185                 190         


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
        195                 200                 205             


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
    210                 215                 220                 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
225                 230                 235                 240 


Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 


<210>  75
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile Glu Lys Arg Gln Ser 
1               5                   10                  15      


Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His Ala Thr Leu Tyr Trp 
            20                  25                  30          


Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu Leu Ile Gln Phe Gln 
        35                  40                  45              


Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro Lys Asp Arg Phe Ser 
    50                  55                  60                  


Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu Lys Ile Gln Pro Ala 
65                  70                  75                  80  


Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu Asp Arg 
                85                  90                  95      


Arg Gly Gly Arg Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu 
            100                 105                 110         


Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
        115                 120                 125             


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
                165                 170                 175     


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
        195                 200                 205             


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
    210                 215                 220                 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
225                 230                 235                 240 


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
                245                 250                 255     


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
            260                 265                 270         


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285         


<210>  76
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Asp Arg Arg Gly Gly Arg Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


His Leu Gln Ser Thr Leu Gly Ala Val Trp Leu Gly Leu Leu Leu Asn 
            340                 345                 350         


Ser Leu Trp Lys Val Ala Glu Ser Lys Asp Gln Val Phe Gln Pro Ser 
        355                 360                 365             


Thr Val Ala Ser Ser Glu Gly Ala Val Val Glu Ile Phe Cys Asn His 
    370                 375                 380                 


Ser Val Ser Asn Ala Tyr Asn Phe Phe Trp Tyr Leu His Phe Pro Gly 
385                 390                 395                 400 


Cys Ala Pro Arg Leu Leu Val Lys Gly Ser Lys Pro Ser Gln Gln Gly 
                405                 410                 415     


Arg Tyr Asn Met Thr Tyr Glu Arg Phe Ser Ser Ser Leu Leu Ile Leu 
            420                 425                 430         


Gln Val Arg Glu Ala Asp Ala Ala Val Tyr Tyr Cys Ala Val Ser Gly 
        435                 440                 445             


Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro Asn 
    450                 455                 460                 


Ile Gln Asn Pro Glu Pro Ala Val Asn Ile Gln Asn Pro Glu Pro Ala 
465                 470                 475                 480 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
                485                 490                 495     


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
            500                 505                 510         


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
        515                 520                 525             


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
    530                 535                 540                 


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
545                 550                 555                 560 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
                565                 570                 575     


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
            580                 585                 590         


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
        595                 600                 605             


Ser 
    


<210>  77
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  78
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  79
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  80
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  81
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe 
                325                 330                 335     


Gln Lys Glu Asn Cys 
            340     


<210>  82
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu 
                325                 330                 335     


Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 
            340                 345     


<210>  83
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu 
    290                 295                 300                 


Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro 
305                 310                 315                 320 


Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys Lys Gly Gln 
                325                 330                 335     


Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu Gly Pro Asp 
            340                 345                 350         


Ser Asp 
        


<210>  84
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn Cys 
    290                 295                 300         


<210>  85
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr Phe Leu Ile 
    290                 295                 300                 


Asn Ser Ser 
305         


<210>  86
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met 
        195                 200                 205             


Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly 
    210                 215                 220                 


Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys 
225                 230                 235                 240 


Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu 
                245                 250                 255     


Gly Pro Asp Ser Asp 
            260     


<210>  87
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn 
        195                 200                 205             


Cys 
    


<210>  88
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr 
        195                 200                 205             


Phe Leu Ile Asn Ser Ser 
    210                 


<210>  89
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  89

Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys Gln Leu Ala 
1               5                   10                  15      


Lys Thr Cys Pro Val Gln Leu Trp Val 
            20                  25  


<210>  90
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  90

Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Tyr Gln Leu Ala 
1               5                   10                  15      


Lys Thr Cys Pro Val Gln Leu Trp Val 
            20                  25  


<210>  91
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  91

His Met Thr Glu Val Val Arg Arg Cys 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  92

His Met Thr Glu Val Val Arg His Cys 
1               5                   


<210>  93
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  93

Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
1               5                   10                  15      


Ser Cys Met Gly Gly Met Asn Arg Arg 
            20                  25  


<210>  94
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  94

Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Ile Cys Asn Ser 
1               5                   10                  15      


Ser Cys Met Gly Gly Met Asn Arg Arg 
            20                  25  


<210>  95
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95

Arg Ala Lys Arg 
1               


<210>  96
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  96

Asn Val Leu Tyr Ser Pro Ala Leu Asn Lys Met Phe Tyr Gln Leu Ala 
1               5                   10                  15      


Lys Thr Cys Pro Val Gln Leu Trp Val 
            20                  25  


<210>  97
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  97

Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Met Phe Tyr Gln Leu Ala 
1               5                   10                  15      


Lys Thr Cys Pro Val Gln Leu Trp Val 
            20                  25  


