                         SEQUENCE LISTING

<110>  Decibel Therapeutics, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING SENSORINEURAL HEARING LOSS 
       USING STEREOCILIN DUAL VECTOR SYSTEMS

<130>  51471-011WO2

<150>  US 63/184,737
<151>  2021-05-05

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  1140
<212>  DNA
<213>  Mus musculus

<400>  1
agcaggtttg ttacagaaac cttagttaag gtttgttgag ggtttttttt ctctctctct       60

ctcttaattg gctgtcccaa tccatccttc tataaataga aaagagagac agggagtgtg      120

tgtggtttca ttactaaggt aaagacactt gagctacaca cacttgatcc ctgaacatga      180

aatctaagag gttgaacgat cacagtttca ggactatata aggtggtgaa agaccatctg      240

cttcgttttt ctgtttgttc ctacaactct ttccctccgc ttgattttaa ctctaaattg      300

gtgagtagct ggtgggctca ccagactccg agatcctctt ctctgcacgc actgtattag      360

acttggcacc cgggaggatt ttcacctctg ctgcatgggc taatcttcca caagggatct      420

gtggtattgc aatctcgggt tgatgcatga cggtgatgtt gtgtttatag catggctaag      480

gtttagctgc ctatgatgat tggttaggga aggataattt ttgctagaag attggacttt      540

agggaaaaaa aaccccactt ttatttgctt ttagaatttt aaaagactgg gccatgtagc      600

tcaggctggt ttggagttca ttatgtagtc aaggatgctc ttggactctt tagcatcctc      660

ctcctcctct ttttcctcct cctccttctt gttcttcttc ttgttcttcc tcttcccctt      720

ctcttccccc ttctctccct cttcctcctc ttcctcctcc ttcttgttct tcttcctctt      780

ccccttctcc tctccccctt gtcctcctct tccttctcct cctcctcctc ttcttctttc      840

tgagtaccaa gattgcaagt gtgcacacga tgaccagctt ggtctttctt tgtctttttt      900

ttttaacttc aattttggag tgaattcaag agcaaccatg tagtcaagag gtggctggag      960

tcttttctgt atctgggttt ggtttagtac tctgccccat cacttaacag gtccttatgg     1020

ccacatctta aaaaaattct agagatacac ggtgtcggtg agtggctgag aatgtgtggt     1080

cttcccattt ctctgtcacc gtggctcaca tcttgtttcc tctgttcggc caggtagaaa     1140


<210>  2
<211>  2500
<212>  DNA
<213>  Homo sapiens

<400>  2
ttttaccaca ataattaaaa agaacagtct agcacagtgc tggccatata aaggctcaat       60

aaatgtttgc tgaaagttaa aaaaaaaaaa aaaaaaaaaa aagccaggcg cagtggttca      120

ttcctgtaat cccagcactt taggaggatg aggtgggaga attacttgag cccaggagtt      180

cgagaccagc ctaggcaaca tggcaaaacc ctgtcaaaac cctgtctctc caaaaaatat      240

gcatatttaa aaaattagcc aggcatggtg gtgtgtgcct gtagtaccag ctactcggga      300

gactgaagtg ggaggatcgc ttgagcctgg gaggtcaagg ctgcaatgag ctgagatcgt      360

gccactgcac tccagccggg gcaacagagc aagaccctgt cacaacagaa acaaaatctt      420

gaggtgtcta gtcctggcct cagcctcaga atatttgttt ctgaacatgt tagttttggg      480

ggttggggat gctggtttga tttcctcctt tttgcctttt gagtgtgtgc aatttatggt      540

atagctggga aacgtcaaag tcaagagttt tgtaggaaag tcacgtcact tagccctgtc      600

tcctgtgccg ggtgagacct gtgtgtgcac ttggtgacaa tggctttgag tctgtcaact      660

ccagactgag gtcagcctta cacacccata gttcccaaag ctgaaaacag gcctgcctcc      720

aacggtacct gctaatatca ggggagcctt ttcagcttac agagcaccct gtatgtgttt      780

gtcttagttc aggccaccat ctccacctta ccaggcatct agaaccttct ccacactttg      840

ccaacagggt tcgtttgcag aattgaaatc ttagttaagg tttgttgaag tttgttgttg      900

tttttttttt ttttttacaa ttggctgttc ccacccacat tcccttgaga cataaataga      960

aaaaaaaaaa aaaagaggtt tcatgagtaa gacaagacat ttgagctgca tccacttgat     1020

ccttgaaaag gaaatctaag aggttgtaac tatcactttt tctagcctat ataaggtagg     1080

tcagtaaggt agcaaaaaca catctgttgt tttgctcctt caactctttt tcctgattct     1140

tcctgggggg aaaccgaaaa cggtgagtaa ctggtggaca catcagaccc cagactcttt     1200

tcttcactgc atgcattcat attaggctca ggtgcttaga ctcctgtttt ccggtggctc     1260

tgacacctgg aaggatttta atctctggga gatgggcttt tcatccatct gcttcccacc     1320

tttcaggaca ggtgcatgcc ttcttccaca gaatgtctgc aagcagccca aactgtatcc     1380

tttcccacgt ggaatttgca acattgcatc tctcgggctg ctgtaggaaa atgccagtgc     1440

atgtgtaaca tggtttacgg ctgcctatgc aaatgactga ttatgtcagt ataattttta     1500

taagaaaaca attgaatcct tctttgggtc attttttttt tccatttttg gcatgtattc     1560

aaaagaaggc tctgagacaa aaaaggctgg ggtgttttcc gtatctggtt ttaatttgga     1620

tattctgtcc cgtcacttaa tacaaaacca tgcttatcac attttaaaaa ttctagacag     1680

gcctggctcg gtggcttgca tctgtcatcc cagcactttg tgaggccaag gcaggcagat     1740

cacctgaggt caggagctca agaccagcct ggccaacatg gcaaaacccc gtctctacta     1800

aaaacacaaa aattagccag gcatggtagt gcgcacctgt aatcccagct actgggaagg     1860

cttaggcagg agaatcactt gagcccagga ggcggaggtt gcggtgagcc gagatcacgc     1920

tcttgcactc cagcctgggt gacagagtga gactccgtct taatttaaaa aaaaaaataa     1980

tctagacaca catacagttt cagtgggcct gggaagatgt gtttcccctg gatgtgcaca     2040

ttcctgtttg tggcttatcg cctctcattt attctgtgtg agtaggtaga aaatgagcat     2100

cacggacgtg ctcagtgctg acgacattgc agcagcgctc caggaatgcc gaggtagagg     2160

ggacgtgagg cgggggtggg atttcctcac agctttgcac ctccagcgag tcaacacaaa     2220

atcaaaatgt aggccaggcg gccagacgca gtggctcaca cctgtaatcc cagcactttg     2280

ggaggccgag gcgggtggat cacgaggtca ggagttcgag accagcctgg ccaagatggt     2340

gaaaccccat ctctactaaa aatacaaaaa aattaaccgg gcgtggtggt gggtgcctgt     2400

aatcccagct actcgggagg ctgaggcaga gaattgcttg aacccgggag gcagaagttg     2460

cagtgagctg agatcatgcc actgcactcc agcctgggca                           2500


<210>  3
<211>  833
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
gttcccaaag ctgaaaacag gcctgcctcc aacggtacct gctaatatca ggggagcctt       60

ttcagcttac agagcaccct gtatgtgttt gtcttagttc aggcacctta ccaggcatct      120

agaaccttct ccacactttg ccaacagggt tcgtttgcag aattgaaatc ttagttaagg      180

tttgttgaag tttgttgttg tttttttttt ttttttacaa ttggctgttc ccacccacat      240

tcccttgaga cataaataga aaaaaaaaaa aaaagaggtt tcatgagtaa gacaagacat      300

ttgagctgca tccacttgat ccttgaaaag gaaatctaag aggttgtaac tatcactttt      360

tctagcctat ataaggtagg tcagtaaggt agcaaaaaca catctgttgt tttgctcctt      420

caactctttt tcctgattct tcctgggggg aaaccgaaaa cggtgagtaa ctggtggaca      480

catcagaccc cagactcttt tcttcactgc atgcattcat attaggctca ggtgcttaga      540

ctcctgtttt ccggtttacg gctgcctatg caaatgactg attatgtcag tataattttt      600

ataagaaaac aattgaatcc ttctttgggt catttttttt ttccattttt ggcatgtatg      660

tgcacattcc tgtttgtggc ttatcgcctc tcatttattc tgtgtgagta ggtagaaaat      720

gagcatcacg gacgtgctca gtgctgacga cattgcagca gcgctccagg aatgccgagg      780

tagaggggac gtgaggcggg ggtgggattt cctcacagct ttgcacctcc agc             833


<210>  4
<211>  1775
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Phe Ala Val Thr Leu Ala Pro Thr Gly Pro His Ser Leu 
            20                  25                  30          


Asp Pro Gly Leu Ser Phe Leu Lys Ser Leu Leu Ser Thr Leu Asp Gln 
        35                  40                  45              


Ala Pro Gln Gly Ser Leu Ser Arg Ser Arg Phe Phe Thr Phe Leu Ala 
    50                  55                  60                  


Asn Ile Ser Ser Ser Phe Glu Pro Gly Arg Met Gly Glu Gly Pro Val 
65                  70                  75                  80  


Gly Glu Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe 
                85                  90                  95      


Leu Val Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu 
            100                 105                 110         


Leu Gly Asp Met Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp 
        115                 120                 125             


Phe Leu Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Val Leu 
    130                 135                 140                 


Leu Gly Ala Leu Val Pro Gly Gly Pro Pro Thr Pro Thr Arg Pro Pro 
145                 150                 155                 160 


Cys Thr Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu 
                165                 170                 175     


Pro Ser Leu Leu Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val 
            180                 185                 190         


Gln Val Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly 
        195                 200                 205             


Arg Glu Ala Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr 
    210                 215                 220                 


Pro Thr Gly Glu Leu Gly Ser Lys Glu Ala Leu Trp Gly Gly Leu Leu 
225                 230                 235                 240 


Arg Thr Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu 
                245                 250                 255     


Arg Val Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Leu Gly Gln 
            260                 265                 270         


Pro Glu Pro Asp Thr Asn Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln 
        275                 280                 285             


Leu Leu Leu Trp Gly Val Arg His Asn Leu Ser Trp Asp Val Gln Ala 
    290                 295                 300                 


Leu Gly Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His 
305                 310                 315                 320 


Cys Leu Ser Thr Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ser Ala 
                325                 330                 335     


His Ile Ser Pro Arg Gln Arg Arg Ala Ile Thr Val Glu Ala Leu Cys 
            340                 345                 350         


Glu Asn His Leu Gly Pro Ala Pro Pro Tyr Ser Ile Ser Asn Phe Ser 
        355                 360                 365             


Ile His Leu Leu Cys Gln His Thr Lys Pro Ala Thr Pro Gln Pro His 
    370                 375                 380                 


Pro Ser Thr Thr Ala Ile Cys Gln Thr Ala Val Trp Tyr Ala Val Ser 
385                 390                 395                 400 


Trp Ala Pro Gly Ala Gln Gly Trp Leu Gln Ala Cys His Asp Gln Phe 
                405                 410                 415     


Pro Asp Glu Phe Leu Asp Ala Ile Cys Ser Asn Leu Ser Phe Ser Ala 
            420                 425                 430         


Leu Ser Gly Ser Asn Arg Arg Leu Val Lys Arg Leu Cys Ala Gly Leu 
        435                 440                 445             


Leu Pro Pro Pro Thr Ser Cys Pro Glu Gly Leu Pro Pro Val Pro Leu 
    450                 455                 460                 


Thr Pro Asp Ile Phe Trp Gly Cys Phe Leu Glu Asn Glu Thr Leu Trp 
465                 470                 475                 480 


Ala Glu Arg Leu Cys Gly Glu Ala Ser Leu Gln Ala Val Pro Pro Ser 
                485                 490                 495     


Asn Gln Ala Trp Val Gln His Val Cys Gln Gly Pro Thr Pro Asp Val 
            500                 505                 510         


Thr Ala Ser Pro Pro Cys His Ile Gly Pro Cys Gly Glu Arg Cys Pro 
        515                 520                 525             


Asp Gly Gly Ser Phe Leu Val Met Val Cys Ala Asn Asp Thr Met Tyr 
    530                 535                 540                 


Glu Val Leu Val Pro Phe Trp Pro Trp Leu Ala Gly Gln Cys Arg Ile 
545                 550                 555                 560 


Ser Arg Gly Gly Asn Asp Thr Cys Phe Leu Glu Gly Leu Leu Gly Pro 
                565                 570                 575     


Leu Leu Pro Ser Leu Pro Pro Leu Gly Pro Ser Pro Leu Cys Leu Thr 
            580                 585                 590         


Pro Gly Pro Phe Leu Leu Gly Met Leu Ser Gln Leu Pro Arg Cys Gln 
        595                 600                 605             


Ser Ser Val Pro Ala Leu Ala His Pro Thr Arg Leu His Tyr Leu Leu 
    610                 615                 620                 


Arg Leu Leu Thr Phe Leu Leu Gly Pro Gly Ala Gly Gly Ala Glu Ala 
625                 630                 635                 640 


Gln Gly Met Leu Gly Arg Ala Leu Leu Leu Ser Ser Leu Pro Asp Asn 
                645                 650                 655     


Cys Ser Phe Trp Asp Ala Phe Arg Pro Glu Gly Arg Arg Ser Val Leu 
            660                 665                 670         


Arg Thr Ile Gly Glu Tyr Leu Glu Gln Asp Glu Glu Gln Pro Thr Pro 
        675                 680                 685             


Ser Gly Phe Glu Pro Thr Val Asn Pro Ser Ser Gly Ile Ser Lys Met 
    690                 695                 700                 


Glu Leu Leu Ala Cys Phe Ser Pro Val Leu Trp Asp Leu Leu Gln Arg 
705                 710                 715                 720 


Glu Lys Ser Val Trp Ala Leu Gln Ile Leu Val Gln Ala Tyr Leu His 
                725                 730                 735     


Met Pro Pro Glu Asn Leu Gln Gln Leu Val Leu Ser Ala Glu Arg Glu 
            740                 745                 750         


Ala Ala Gln Gly Phe Leu Thr Leu Met Leu Gln Gly Lys Leu Gln Gly 
        755                 760                 765             


Lys Leu Gln Val Pro Pro Ser Glu Glu Gln Ala Leu Gly Arg Leu Thr 
    770                 775                 780                 


Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser Gln Leu Phe Ile 
785                 790                 795                 800 


Asp Leu Ser Pro Leu Ile Pro Phe Leu Ala Val Ser Asp Leu Met Arg 
                805                 810                 815     


Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu Ala Ala Ile Arg 
            820                 825                 830         


Asp Tyr Ser Pro Gly Met Arg Pro Glu Gln Lys Glu Ala Leu Ala Lys 
        835                 840                 845             


Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro Ala Trp Pro Gln 
    850                 855                 860                 


Glu Leu Leu Trp Ala Val Leu Pro Leu Leu Pro His Leu Pro Leu Glu 
865                 870                 875                 880 


Asn Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala Leu Glu Asp Ser 
                885                 890                 895     


Trp Pro Ala Ala Gly Leu Gly Pro Gly His Ala Arg His Val Leu Arg 
            900                 905                 910         


Ser Leu Val Asn Gln Ser Val Gln Asp Gly Glu Glu Gln Val Arg Arg 
        915                 920                 925             


Leu Gly Pro Leu Ala Cys Phe Leu Ser Pro Glu Glu Leu Gln Ser Leu 
    930                 935                 940                 


Val Pro Leu Ser Asp Pro Thr Gly Pro Val Glu Arg Gly Leu Leu Glu 
945                 950                 955                 960 


Cys Ala Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg Val Ala Tyr Glu 
                965                 970                 975     


Leu Leu Gly Val Leu Arg Ser Ser Gly Gly Ala Val Leu Ser Pro Arg 
            980                 985                 990         


Glu Leu Arg Val Trp Ala Pro Leu  Phe Ser Gln Leu Gly  Leu Arg Phe 
        995                 1000                 1005             


Leu Gln  Glu Leu Ser Glu Pro  Gln Leu Arg Ala Met  Leu Pro Val 
    1010                 1015                 1020             


Leu Gln  Gly Thr Ser Val Thr  Pro Ala Gln Ala Val  Leu Leu Leu 
    1025                 1030                 1035             


Gly Arg  Leu Leu Pro Arg His  Asp Leu Ser Leu Glu  Glu Leu Cys 
    1040                 1045                 1050             


Ser Leu  His Leu Leu Leu Pro  Gly Leu Ser Pro Gln  Thr Leu Gln 
    1055                 1060                 1065             


Ala Ile  Pro Arg Arg Val Leu  Val Gly Ala Cys Ser  Cys Leu Ala 
    1070                 1075                 1080             


Pro Glu  Leu Ser Arg Leu Ser  Ala Cys Gln Thr Ala  Ala Leu Leu 
    1085                 1090                 1095             


Gln Thr  Phe Arg Val Lys Asp  Gly Val Lys Asn Met  Gly Thr Thr 
    1100                 1105                 1110             


Gly Ala  Gly Pro Ala Val Cys  Ile Pro Gly Gln Pro  Ile Pro Thr 
    1115                 1120                 1125             


Thr Trp  Pro Asp Cys Leu Leu  Pro Leu Leu Pro Leu  Lys Leu Leu 
    1130                 1135                 1140             


Gln Leu  Asp Ser Leu Ala Leu  Leu Ala Asn Arg Arg  Arg Tyr Trp 
    1145                 1150                 1155             


Glu Leu  Pro Trp Ser Glu Gln  Gln Ala Gln Phe Leu  Trp Lys Lys 
    1160                 1165                 1170             


Met Gln  Val Pro Thr Asn Leu  Thr Leu Arg Asn Leu  Gln Ala Leu 
    1175                 1180                 1185             


Gly Thr  Leu Ala Gly Gly Met  Ser Cys Glu Phe Leu  Gln Gln Ile 
    1190                 1195                 1200             


Asn Ser  Met Val Asp Phe Leu  Glu Val Val His Met  Ile Tyr Gln 
    1205                 1210                 1215             


Leu Pro  Thr Arg Val Arg Gly  Ser Leu Arg Ala Cys  Ile Trp Ala 
    1220                 1225                 1230             


Glu Leu  Gln Arg Arg Met Ala  Met Pro Glu Pro Glu  Trp Thr Thr 
    1235                 1240                 1245             


Val Gly  Pro Glu Leu Asn Gly  Leu Asp Ser Lys Leu  Leu Leu Asp 
    1250                 1255                 1260             


Leu Pro  Ile Gln Leu Met Asp  Arg Leu Ser Asn Glu  Ser Ile Met 
    1265                 1270                 1275             


Leu Val  Val Glu Leu Val Gln  Arg Ala Pro Glu Gln  Leu Leu Ala 
    1280                 1285                 1290             


Leu Thr  Pro Leu His Gln Ala  Ala Leu Ala Glu Arg  Ala Leu Gln 
    1295                 1300                 1305             


Asn Leu  Ala Pro Lys Glu Thr  Pro Val Ser Gly Glu  Val Leu Glu 
    1310                 1315                 1320             


Thr Leu  Gly Pro Leu Val Gly  Phe Leu Gly Thr Glu  Ser Thr Arg 
    1325                 1330                 1335             


Gln Ile  Pro Leu Gln Ile Leu  Leu Ser His Leu Ser  Gln Leu Gln 
    1340                 1345                 1350             


Gly Phe  Cys Leu Gly Glu Thr  Phe Ala Thr Glu Leu  Gly Trp Leu 
    1355                 1360                 1365             


Leu Leu  Gln Glu Ser Val Leu  Gly Lys Pro Glu Leu  Trp Ser Gln 
    1370                 1375                 1380             


Asp Glu  Val Glu Gln Ala Gly  Arg Leu Val Phe Thr  Leu Ser Thr 
    1385                 1390                 1395             


Glu Ala  Ile Ser Leu Ile Pro  Arg Glu Ala Leu Gly  Pro Glu Thr 
    1400                 1405                 1410             


Leu Glu  Arg Leu Leu Glu Lys  Gln Gln Ser Trp Glu  Gln Ser Arg 
    1415                 1420                 1425             


Val Gly  Gln Leu Cys Arg Glu  Pro Gln Leu Ala Ala  Lys Lys Ala 
    1430                 1435                 1440             


Ala Leu  Val Ala Gly Val Val  Arg Pro Ala Ala Glu  Asp Leu Pro 
    1445                 1450                 1455             


Glu Pro  Val Pro Asn Cys Ala  Asp Val Arg Gly Thr  Phe Pro Ala 
    1460                 1465                 1470             


Ala Trp  Ser Ala Thr Gln Ile  Ala Glu Met Glu Leu  Ser Asp Phe 
    1475                 1480                 1485             


Glu Asp  Cys Leu Thr Leu Phe  Ala Gly Asp Pro Gly  Leu Gly Pro 
    1490                 1495                 1500             


Glu Glu  Leu Arg Ala Ala Met  Gly Lys Ala Lys Gln  Leu Trp Gly 
    1505                 1510                 1515             


Pro Pro  Arg Gly Phe Arg Pro  Glu Gln Ile Leu Gln  Leu Gly Arg 
    1520                 1525                 1530             


Leu Leu  Ile Gly Leu Gly Asp  Arg Glu Leu Gln Glu  Leu Ile Leu 
    1535                 1540                 1545             


Val Asp  Trp Gly Val Leu Ser  Thr Leu Gly Gln Ile  Asp Gly Trp 
    1550                 1555                 1560             


Ser Thr  Thr Gln Leu Arg Ile  Val Val Ser Ser Phe  Leu Arg Gln 
    1565                 1570                 1575             


Ser Gly  Arg His Val Ser His  Leu Asp Phe Val His  Leu Thr Ala 
    1580                 1585                 1590             


Leu Gly  Tyr Thr Leu Cys Gly  Leu Arg Pro Glu Glu  Leu Gln His 
    1595                 1600                 1605             


Ile Ser  Ser Trp Glu Phe Ser  Gln Ala Ala Leu Phe  Leu Gly Thr 
    1610                 1615                 1620             


Leu His  Leu Gln Cys Ser Glu  Glu Gln Leu Glu Val  Leu Ala His 
    1625                 1630                 1635             


Leu Leu  Val Leu Pro Gly Gly  Phe Gly Pro Ile Ser  Asn Trp Gly 
    1640                 1645                 1650             


Pro Glu  Ile Phe Thr Glu Ile  Gly Thr Ile Ala Ala  Gly Ile Pro 
    1655                 1660                 1665             


Asp Leu  Ala Leu Ser Ala Leu  Leu Arg Gly Gln Ile  Gln Gly Val 
    1670                 1675                 1680             


Thr Pro  Leu Ala Ile Ser Val  Ile Pro Pro Pro Lys  Phe Ala Val 
    1685                 1690                 1695             


Val Phe  Ser Pro Ile Gln Leu  Ser Ser Leu Thr Ser  Ala Gln Ala 
    1700                 1705                 1710             


Val Ala  Val Thr Pro Glu Gln  Met Ala Phe Leu Ser  Pro Glu Gln 
    1715                 1720                 1725             


Arg Arg  Ala Val Ala Trp Ala  Gln His Glu Gly Lys  Glu Ser Pro 
    1730                 1735                 1740             


Glu Gln  Gln Gly Arg Ser Thr  Ala Trp Gly Leu Gln  Asp Trp Ser 
    1745                 1750                 1755             


Arg Pro  Ser Trp Ser Leu Val  Leu Thr Ile Ser Phe  Leu Gly His 
    1760                 1765                 1770             


Leu Leu  
    1775 


<210>  5
<211>  1809
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Leu Ser Leu Gln Pro Gln Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Pro Gln Glu Val Thr Ser Ala Pro Thr Gly Pro Gln Ser Leu Asp Ala 
            20                  25                  30          


Gly Leu Ser Leu Leu Lys Ser Phe Val Ala Thr Leu Asp Gln Ala Pro 
        35                  40                  45              


Gln Arg Ser Leu Ser Gln Ser Arg Phe Ser Ala Phe Leu Ala Asn Ile 
    50                  55                  60                  


Ser Ser Ser Phe Gln Leu Gly Arg Met Gly Glu Gly Pro Val Gly Glu 
65                  70                  75                  80  


Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe Leu Val 
                85                  90                  95      


Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu Leu Gly 
            100                 105                 110         


Asp Val Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp Phe Leu 
        115                 120                 125             


Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Ala Leu Leu Gly 
    130                 135                 140                 


Ala Leu Val Pro Gly Gly Pro Pro Ala Pro Thr Arg Pro Pro Cys Thr 
145                 150                 155                 160 


Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu Pro Ser 
                165                 170                 175     


Leu Met Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val Gln Leu 
            180                 185                 190         


Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly Arg Glu 
        195                 200                 205             


Pro Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr Pro Ala 
    210                 215                 220                 


Gly Glu Leu Gly Ser Glu Glu Ala Leu Trp Gly Gly Leu Leu Arg Thr 
225                 230                 235                 240 


Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu Arg Val 
                245                 250                 255     


Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Met Gly Gln Pro Glu 
            260                 265                 270         


Pro Asp Ala Ser Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln Leu Leu 
        275                 280                 285             


Leu Trp Gly Met Arg Asn Asn Leu Ser Trp Asp Ala Arg Ala Leu Gly 
    290                 295                 300                 


Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His Cys Leu 
305                 310                 315                 320 


Ser Arg Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ala Ala His Ile 
                325                 330                 335     


Ser Pro Arg Gln Arg Arg Ala Ile Ser Val Glu Ala Leu Cys Glu Asn 
            340                 345                 350         


His Ser Gly Pro Glu Pro Pro Tyr Ser Ile Ser Asn Phe Ser Ile Tyr 
        355                 360                 365             


Leu Leu Cys Gln His Ile Lys Pro Ala Thr Pro Arg Pro Pro Pro Thr 
    370                 375                 380                 


Thr Pro Arg Pro Pro Pro Thr Thr Pro Gln Pro Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Gln Pro Ile Pro Asp Thr Thr Gln Pro Pro Pro Val Thr Pro Arg Pro 
                405                 410                 415     


Pro Pro Thr Thr Pro Gln Pro Pro Pro Ser Thr Ala Val Ile Cys Gln 
            420                 425                 430         


Thr Ala Val Trp Tyr Ala Val Ser Trp Ala Pro Gly Ala Arg Gly Trp 
        435                 440                 445             


Leu Gln Ala Cys His Asp Gln Phe Pro Asp Gln Phe Leu Asp Met Ile 
    450                 455                 460                 


Cys Gly Asn Leu Ser Phe Ser Ala Leu Ser Gly Pro Ser Arg Pro Leu 
465                 470                 475                 480 


Val Lys Gln Leu Cys Ala Gly Leu Leu Pro Pro Pro Thr Ser Cys Pro 
                485                 490                 495     


Pro Gly Leu Ile Pro Val Pro Leu Thr Pro Glu Ile Phe Trp Gly Cys 
            500                 505                 510         


Phe Leu Glu Asn Glu Thr Leu Trp Ala Glu Arg Leu Cys Val Glu Asp 
        515                 520                 525             


Ser Leu Gln Ala Val Pro Pro Arg Asn Gln Ala Trp Val Gln His Val 
    530                 535                 540                 


Cys Arg Gly Pro Thr Leu Asp Ala Thr Asp Phe Pro Pro Cys Arg Val 
545                 550                 555                 560 


Gly Pro Cys Gly Glu Arg Cys Pro Asp Gly Gly Ser Phe Leu Leu Met 
                565                 570                 575     


Val Cys Ala Asn Asp Thr Leu Tyr Glu Ala Leu Val Pro Phe Trp Ala 
            580                 585                 590         


Trp Leu Ala Gly Gln Cys Arg Ile Ser Arg Gly Gly Asn Asp Thr Cys 
        595                 600                 605             


Phe Leu Glu Gly Met Leu Gly Pro Leu Leu Pro Ser Leu Pro Pro Leu 
    610                 615                 620                 


Gly Pro Ser Pro Leu Cys Leu Ala Pro Gly Pro Phe Leu Leu Gly Met 
625                 630                 635                 640 


Leu Ser Gln Leu Pro Arg Cys Gln Ser Ser Val Pro Ala Leu Ala His 
                645                 650                 655     


Pro Thr Arg Leu His Tyr Leu Leu Arg Leu Leu Thr Phe Leu Leu Gly 
            660                 665                 670         


Pro Gly Thr Gly Gly Ala Glu Thr Gln Gly Met Leu Gly Gln Ala Leu 
        675                 680                 685             


Leu Leu Ser Ser Leu Pro Asp Asn Cys Ser Phe Trp Asp Ala Phe Arg 
    690                 695                 700                 


Pro Glu Gly Arg Arg Ser Val Leu Arg Thr Val Gly Glu Tyr Leu Gln 
705                 710                 715                 720 


Arg Glu Glu Pro Thr Pro Pro Gly Leu Asp Ser Ser Leu Ser Leu Gly 
                725                 730                 735     


Ser Gly Met Ser Lys Met Glu Leu Leu Ser Cys Phe Ser Pro Val Leu 
            740                 745                 750         


Trp Asp Leu Leu Gln Arg Glu Lys Ser Val Trp Ala Leu Arg Thr Leu 
        755                 760                 765             


Val Lys Ala Tyr Leu Arg Met Pro Pro Glu Asp Leu Gln Gln Leu Val 
    770                 775                 780                 


Leu Ser Ala Glu Met Glu Ala Ala Gln Gly Phe Leu Thr Leu Met Leu 
785                 790                 795                 800 


Arg Ser Trp Ala Lys Leu Lys Val Gln Pro Ser Glu Glu Gln Ala Met 
                805                 810                 815     


Gly Arg Leu Thr Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser 
            820                 825                 830         


Gln Leu Phe Ile Asp Met Ser Pro Leu Ile Pro Phe Leu Ala Val Pro 
        835                 840                 845             


Asp Leu Met Arg Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu 
    850                 855                 860                 


Ala Ala Ile Arg Asp His Ser Ser Gly Met Lys Pro Glu Gln Lys Glu 
865                 870                 875                 880 


Ala Leu Ala Lys Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro 
                885                 890                 895     


Asp Trp Pro Gln Glu Leu Leu Trp Ala Ala Leu Pro Leu Leu Pro His 
            900                 905                 910         


Leu Pro Leu Glu Ser Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala 
        915                 920                 925             


Leu Glu Asp Ser Trp Pro Val Ala Asp Leu Gly Pro Gly His Ala Arg 
    930                 935                 940                 


His Val Leu Arg Ser Leu Val Asn Gln Ser Met Glu Asp Gly Glu Glu 
945                 950                 955                 960 


Gln Val Leu Arg Leu Gly Ser Leu Ala Cys Phe Leu Ser Pro Glu Glu 
                965                 970                 975     


Leu Gln Ser Leu Val Pro Leu Ser Asp Pro Met Gly Pro Val Glu Gln 
            980                 985                 990         


Gly Leu Leu Glu Cys Ala Ala Asn  Gly Thr Leu Ser Pro  Glu Gly Arg 
        995                 1000                 1005             


Val Ala  Tyr Glu Leu Leu Gly  Val Leu Arg Ser Ser  Gly Gly Thr 
    1010                 1015                 1020             


Val Leu  Ser Pro Arg Glu Leu  Arg Val Trp Ala Pro  Leu Phe Pro 
    1025                 1030                 1035             


Gln Leu  Gly Leu Arg Phe Leu  Gln Glu Leu Ser Glu  Thr Gln Leu 
    1040                 1045                 1050             


Arg Ala  Met Leu Pro Ala Leu  Gln Gly Ala Ser Val  Thr Pro Ala 
    1055                 1060                 1065             


Gln Ala  Val Leu Leu Phe Gly  Arg Leu Leu Pro Lys  His Asp Leu 
    1070                 1075                 1080             


Ser Leu  Glu Glu Leu Cys Ser  Leu His Pro Leu Leu  Pro Gly Leu 
    1085                 1090                 1095             


Ser Pro  Gln Thr Leu Gln Ala  Ile Pro Lys Arg Val  Leu Val Gly 
    1100                 1105                 1110             


Ala Cys  Ser Cys Leu Gly Pro  Glu Leu Ser Arg Leu  Ser Ala Cys 
    1115                 1120                 1125             


Gln Ile  Ala Ala Leu Leu Gln  Thr Phe Arg Val Lys  Asp Gly Val 
    1130                 1135                 1140             


Lys Asn  Met Gly Ala Ala Gly  Ala Gly Ser Ala Val  Cys Ile Pro 
    1145                 1150                 1155             


Gly Gln  Pro Thr Thr Trp Pro  Asp Cys Leu Leu Pro  Leu Leu Pro 
    1160                 1165                 1170             


Leu Lys  Leu Leu Gln Leu Asp  Ala Ala Ala Leu Leu  Ala Asn Arg 
    1175                 1180                 1185             


Arg Leu  Tyr Arg Gln Leu Pro  Trp Ser Glu Gln Gln  Ala Gln Phe 
    1190                 1195                 1200             


Leu Trp  Lys Lys Met Gln Val  Pro Thr Asn Leu Ser  Leu Arg Asn 
    1205                 1210                 1215             


Leu Gln  Ala Leu Gly Asn Leu  Ala Gly Gly Met Thr  Cys Glu Phe 
    1220                 1225                 1230             


Leu Gln  Gln Ile Ser Ser Met  Val Asp Phe Leu Asp  Val Val His 
    1235                 1240                 1245             


Met Leu  Tyr Gln Leu Pro Thr  Gly Val Arg Glu Ser  Leu Arg Ala 
    1250                 1255                 1260             


Cys Ile  Trp Thr Glu Leu Gln  Arg Arg Met Thr Met  Pro Glu Pro 
    1265                 1270                 1275             


Glu Leu  Thr Thr Leu Gly Pro  Glu Leu Ser Glu Leu  Asp Thr Lys 
    1280                 1285                 1290             


Leu Leu  Leu Asp Leu Pro Ile  Gln Leu Met Asp Arg  Leu Ser Asn 
    1295                 1300                 1305             


Asp Ser  Ile Met Leu Val Val  Glu Met Val Gln Gly  Ala Pro Glu 
    1310                 1315                 1320             


Gln Leu  Leu Ala Leu Thr Pro  Leu His Gln Thr Ala  Leu Ala Glu 
    1325                 1330                 1335             


Arg Ala  Leu Lys Asn Leu Ala  Pro Lys Glu Thr Pro  Ile Ser Lys 
    1340                 1345                 1350             


Glu Val  Leu Glu Thr Leu Gly  Pro Leu Val Gly Phe  Leu Gly Ile 
    1355                 1360                 1365             


Glu Ser  Thr Arg Arg Ile Pro  Leu Pro Ile Leu Leu  Ser His Leu 
    1370                 1375                 1380             


Ser Gln  Leu Gln Gly Phe Cys  Leu Gly Glu Thr Phe  Ala Thr Glu 
    1385                 1390                 1395             


Leu Gly  Trp Leu Leu Leu Gln  Glu Pro Val Leu Gly  Lys Pro Glu 
    1400                 1405                 1410             


Leu Trp  Ser Gln Asp Glu Ile  Glu Gln Ala Gly Arg  Leu Val Phe 
    1415                 1420                 1425             


Thr Leu  Ser Ala Glu Ala Ile  Ser Ser Ile Pro Arg  Glu Ala Leu 
    1430                 1435                 1440             


Gly Pro  Glu Thr Leu Glu Arg  Leu Leu Gly Lys His  Gln Ser Trp 
    1445                 1450                 1455             


Glu Gln  Ser Arg Val Gly His  Leu Cys Gly Glu Ser  Gln Leu Ala 
    1460                 1465                 1470             


His Lys  Lys Ala Ala Leu Val  Ala Gly Ile Val His  Pro Ala Ala 
    1475                 1480                 1485             


Glu Gly  Leu Gln Glu Pro Val  Pro Asn Cys Ala Asp  Ile Arg Gly 
    1490                 1495                 1500             


Thr Phe  Pro Ala Ala Trp Ser  Ala Thr Gln Ile Ser  Glu Met Glu 
    1505                 1510                 1515             


Leu Ser  Asp Phe Glu Asp Cys  Leu Ser Leu Phe Ala  Gly Asp Pro 
    1520                 1525                 1530             


Gly Leu  Gly Pro Glu Glu Leu  Arg Ala Ala Met Gly  Lys Ala Lys 
    1535                 1540                 1545             


Gln Leu  Trp Gly Pro Pro Arg  Gly Phe Arg Pro Glu  Gln Ile Leu 
    1550                 1555                 1560             


Gln Leu  Gly Arg Leu Leu Ile  Gly Leu Gly Glu Arg  Glu Leu Gln 
    1565                 1570                 1575             


Glu Leu  Thr Leu Val Asp Trp  Gly Val Leu Ser Ser  Leu Gly Gln 
    1580                 1585                 1590             


Ile Asp  Gly Trp Ser Ser Met  Gln Leu Arg Ala Val  Val Ser Ser 
    1595                 1600                 1605             


Phe Leu  Arg Gln Ser Gly Arg  His Val Ser His Leu  Asp Phe Ile 
    1610                 1615                 1620             


Tyr Leu  Thr Ala Leu Gly Tyr  Thr Val Cys Gly Leu  Arg Pro Glu 
    1625                 1630                 1635             


Glu Leu  Gln His Ile Ser Ser  Trp Glu Phe Ser Gln  Ala Ala Leu 
    1640                 1645                 1650             


Phe Leu  Gly Ser Leu His Leu  Pro Cys Ser Glu Glu  Gln Leu Glu 
    1655                 1660                 1665             


Val Leu  Ala Tyr Leu Leu Val  Leu Pro Gly Gly Phe  Gly Pro Val 
    1670                 1675                 1680             


Ser Asn  Trp Gly Pro Glu Ile  Phe Thr Glu Ile Gly  Thr Ile Ala 
    1685                 1690                 1695             


Ala Gly  Ile Pro Asp Leu Ala  Leu Ser Ala Leu Leu  Arg Gly Gln 
    1700                 1705                 1710             


Ile Gln  Gly Leu Thr Pro Leu  Ala Ile Ser Val Ile  Pro Ala Pro 
    1715                 1720                 1725             


Lys Phe  Ala Val Val Phe Asn  Pro Ile Gln Leu Ser  Ser Leu Thr 
    1730                 1735                 1740             


Arg Gly  Gln Ala Val Ala Val  Thr Pro Glu Gln Leu  Ala Tyr Leu 
    1745                 1750                 1755             


Ser Pro  Glu Gln Arg Arg Ala  Val Ala Trp Ala Gln  His Glu Gly 
    1760                 1765                 1770             


Lys Glu  Ile Pro Glu Gln Leu  Gly Arg Asn Ser Ala  Trp Gly Leu 
    1775                 1780                 1785             


Tyr Asp  Trp Phe Gln Ala Ser  Trp Ala Leu Ala Leu  Pro Val Ser 
    1790                 1795                 1800             


Ile Phe  Gly His Leu Leu 
    1805                 


<210>  6
<211>  5328
<212>  DNA
<213>  Homo sapiens

<400>  6
atggctctca gcctctggcc cctgctgctg ctgctgctgc tgctgctgct gctgtccttt       60

gcagtgactc tggcccctac tgggcctcat tccctggacc ctggtctctc cttcctgaag      120

tcattgctct ccactctgga ccaggctccc cagggctccc tgagccgctc acggttcttt      180

acattcctgg ccaacatttc ttcttccttt gagcctggga gaatggggga aggaccagta      240

ggagagcccc cacctctcca gccgcctgct ctgcggctcc atgattttct agtgacactg      300

agaggtagcc ccgactggga gccaatgcta gggctgctag gggatatgct ggcactgctg      360

ggacaggagc agactccccg agatttcctg gtgcaccagg caggggtgct gggtggactt      420

gtggaggtgc tgctgggagc cttagttcct gggggccccc ctaccccaac tcggccccca      480

tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg actggttgcc ttctctgctg      540

ctgttgttag agggcacacg ctggcaagct ctggtgcagg tgcagcccag tgtggacccc      600

accaatgcca caggcctcga tgggagggag gcagctcctc actttttgca gggtctgttg      660

ggtttgctta ccccaacagg ggagctaggc tccaaggagg ctctttgggg cggtctgcta      720

cgcacagtgg gggcccccct ctatgctgcc tttcaggagg ggctgctccg tgtcactcac      780

tccctgcagg atgaggtctt ctccattttg gggcagccag agcctgatac caatgggcag      840

tgccagggag gtaaccttca acagctgctc ttatggggcg tccggcacaa cctttcctgg      900

gatgtccagg cgctgggctt tctgtctgga tcaccacccc caccccctgc cctccttcac      960

tgcctgagca cgggcgtgcc tctgcccaga gcttctcagc cgtcagccca catcagccca     1020

cgccaacggc gagccatcac tgtggaggcc ctctgtgaga accacttagg cccagcacca     1080

ccctacagca tttccaactt ctccatccac ttgctctgcc agcacaccaa gcctgccact     1140

ccacagcccc atcccagcac cactgccatc tgccagacag ctgtgtggta tgcagtgtcc     1200

tgggcaccag gtgcccaagg ctggctacag gcctgccacg accagtttcc tgatgagttt     1260

ttggatgcga tctgcagtaa cctctccttt tcagccctgt ctggctccaa ccgccgcctg     1320

gtgaagcggc tctgtgctgg cctgctccca ccccctacca gctgccctga aggcctgccc     1380

cctgttcccc tcaccccaga catcttttgg ggctgcttct tggagaatga gactctgtgg     1440

gctgagcgac tgtgtgggga ggcaagtcta caggctgtgc cccccagcaa ccaggcttgg     1500

gtccagcatg tgtgccaggg ccccacccca gatgtcactg cctccccacc atgccacatt     1560

ggaccctgtg gggaacgctg cccggatggg ggcagcttcc tggtgatggt ctgtgccaat     1620

gacaccatgt atgaggtcct ggtgcccttc tggccttggc tagcaggcca atgcaggata     1680

agtcgtgggg gcaatgacac ttgcttccta gaagggctgc tgggccccct tctgccctct     1740

ctgccaccac tgggaccatc cccactctgt ctgacccctg gccccttcct ccttggcatg     1800

ctatcccagt tgccacgctg tcagtcctct gtcccagctc ttgctcaccc cacacgccta     1860

cactatctcc tccgcctgct gaccttcctc ttgggtccag gggctggggg cgctgaggcc     1920

caggggatgc tgggtcgggc cctactgctc tccagtctcc cagacaactg ctccttctgg     1980

gatgcctttc gcccagaggg ccggcgcagt gtgctacgga cgattgggga atacctggaa     2040

caagatgagg agcagccaac cccatcaggc tttgaaccca ctgtcaaccc cagctctggt     2100

ataagcaaga tggagctgct ggcctgcttt agtcctgtgc tgtgggatct gctccagagg     2160

gaaaagagtg tttgggccct gcagattcta gtgcaggcgt acctgcatat gcccccagaa     2220

aacctccagc agctggtgct ttcagcagag agggaggctg cacagggctt cctgacactc     2280

atgctgcagg ggaagctgca ggggaagctg caggtaccac catccgagga gcaggccctg     2340

ggtcgcctga cagccctgct gctccagcgg tacccacgcc tcacctccca gctcttcatt     2400

gacctgtcac cactcatccc tttcttggct gtctctgacc tgatgcgctt cccaccatcc     2460

ctgttagcca acgacagtgt cctggctgcc atccgggatt acagcccagg aatgaggcct     2520

gaacagaagg aggctctggc aaagcgactg ctggcccctg aactgtttgg ggaagtgcct     2580

gcctggcccc aggagctgct gtgggcagtg ctgcccctgc tcccccacct ccctctggag     2640

aactttttgc agctcagccc tcaccagatc caggccctgg aggatagctg gccagcagca     2700

ggtctggggc cagggcatgc ccgccatgtg ctgcgcagcc tggtaaacca gagtgtccag     2760

gatggtgagg agcaggtacg caggcttggg cccctcgcct gtttcctgag ccctgaggag     2820

ctgcagagcc tagtgcccct gagtgatcca acggggccag tagaacgggg gctgctggaa     2880

tgtgcagcca atgggaccct cagcccagaa ggacgggtgg catatgaact tctgggtgtg     2940

ttgcgctcat ctggaggagc ggtgctgagc ccccgggagc tgcgggtctg ggcccctctc     3000

ttctctcagc tgggcctccg cttccttcag gagctgtcag agccccagct tagagccatg     3060

cttcctgtcc tgcagggaac tagtgttaca cctgctcagg ctgtcctgct gcttggacgg     3120

ctccttccta ggcacgatct atccctggag gaactctgct ccttgcacct tctgctacca     3180

ggcctcagcc cccagacact ccaggccatc cctaggcgag tcctggtcgg ggcttgttcc     3240

tgcctggccc ctgaactgtc acgcctctca gcctgccaga ccgcagcact gctgcagacc     3300

tttcgggtta aagatggtgt taaaaatatg ggtacaacag gtgctggtcc agctgtgtgt     3360

atccctggtc agcctattcc caccacctgg ccagactgcc tgcttcccct gctcccatta     3420

aagctgctac aactggattc cttggctctt ctggcaaatc gaagacgcta ctgggagctg     3480

ccctggtctg agcagcaggc acagtttctc tggaagaaga tgcaagtacc caccaacctt     3540

accctcagga atctgcaggc tctgggcacc ctggcaggag gcatgtcctg tgagtttctg     3600

cagcagatca actccatggt agacttcctt gaagtggtgc acatgatcta tcagctgccc     3660

actagagttc gagggagcct gagggcctgt atctgggcag agctacagcg gaggatggca     3720

atgccagaac cagaatggac aactgtaggg ccagaactga acgggctgga tagcaagcta     3780

ctcctggact taccgatcca gttgatggac agactatcca atgaatccat tatgttggtg     3840

gtggagctgg tgcaaagagc tccagagcag ctgctggcac tgacccccct ccaccaggca     3900

gccctggcag agagggcact acaaaacctg gctccaaagg agactccagt ctcaggggaa     3960

gtgctggaga ccttaggccc tttggttgga ttcctgggga cagagagcac acgacagatc     4020

cccctacaga tcctgctgtc ccatctcagt cagctgcaag gcttctgcct aggagagaca     4080

tttgccacag agctgggatg gctgctattg caggagtctg ttcttgggaa accagagttg     4140

tggagccagg atgaagtaga gcaagctgga cgcctagtat tcactctgtc tactgaggca     4200

atttccttga tccccaggga ggccttgggt ccagagaccc tggagcggct tctagaaaag     4260

cagcagagct gggagcagag cagagttgga cagctgtgta gggagccaca gcttgctgcc     4320

aagaaagcag ccctggtagc aggggtggtg cgaccagctg ctgaggatct tccagaacct     4380

gtgccaaatt gtgcagatgt acgagggaca ttcccagcag cctggtctgc aacccagatt     4440

gcagagatgg agctctcaga ctttgaggac tgcctgacat tatttgcagg agacccagga     4500

cttgggcctg aggaactgcg ggcagccatg ggcaaagcaa aacagttgtg gggtcccccc     4560

cggggatttc gtcctgagca gatcctgcag cttggtaggc tcttaatagg tctaggagat     4620

cgggaactac aggagctgat cctagtggac tggggagtgc tgagcaccct ggggcagata     4680

gatggctgga gcaccactca gctccgcatt gtggtctcca gtttcctacg gcagagtggt     4740

cggcatgtga gccacctgga cttcgttcat ctgacagcgc tgggttatac tctctgtgga     4800

ctgcggccag aggagctcca gcacatcagc agttgggagt tcagccaagc agctctcttc     4860

ctcggcaccc tgcatctcca gtgctctgag gaacaactgg aggttctggc ccacctactt     4920

gtactgcctg gtgggtttgg cccaatcagt aactgggggc ctgagatctt cactgaaatt     4980

ggcaccatag cagctgggat cccagacctg gctctttcag cactgctgcg gggacagatc     5040

cagggcgtta ctcctcttgc catttctgtc atccctcctc ctaaatttgc tgtggtgttt     5100

agtcccatcc aactatctag tctcaccagt gctcaggctg tggctgtcac tcctgagcaa     5160

atggcctttc tgagtcctga gcagcgacga gcagttgcat gggcccaaca tgagggaaag     5220

gagagcccag aacagcaagg tcgaagtaca gcctggggcc tccaggactg gtcacgacct     5280

tcctggtccc tggtattgac tatcagcttc cttggccacc tgctatga                  5328


<210>  7
<211>  5430
<212>  DNA
<213>  Mus musculus

<400>  7
atggctctga gcctccagcc ccagctgctc cttctcctgt cgctcctgcc gcaggaagtg       60

acttcagccc ctactgggcc tcagtctttg gatgctggtc tctcccttct gaagtcattc      120

gtagccactc tggaccaagc tcctcagcgt tccctcagcc agtcacggtt ctctgcgttc      180

ctggccaaca tttcttcatc cttccagctt gggaggatgg gggagggacc ggtgggagag      240

cccccacctc tccagccccc tgcacttcga cttcatgatt tcctcgtgac actgagaggt      300

agcccagact gggagccaat gctagggctt ctgggagatg tgctggcact cctgggacag      360

gaacagactc cccgggactt tttggtgcac caggcaggtg tactgggtgg acttgtagag      420

gcattgttgg gagcgttagt tcctggaggc ccccctgccc ccactcgacc cccatgcacc      480

cgtgatggcc cttctgactg tgtcctggct gctgattggt tgccttctct gatgttgtta      540

ttagagggta cacgctggca ggccctggtg cagttgcagc ccagtgtgga cccaaccaat      600

gccacaggtc ttgatggtag agagccagct cctcactttt tacagggtct gctgggcttg      660

cttaccccag caggagagtt gggctctgag gaggctcttt ggggtggtct gctgcgcaca      720

gtgggggccc ccctctatgc tgccttccag gaggggctac tgcgagtcac tcattctctg      780

caagatgagg tcttttctat tatgggacag ccagagcctg atgccagtgg gcagtgccag      840

ggaggcaacc ttcaacagct gcttttatgg ggcatgcgga acaacctttc ttgggacgcc      900

cgagcactgg gttttctatc tggatcacca cctccacccc ctgctctcct gcactgcctg      960

agcagaggtg tgcctctgcc cagggcttcc cagcctgcgg ctcacatcag ccctcgacag     1020

cggcgagcca tctctgtgga ggccctctgc gagaaccact caggcccaga gccaccctac     1080

agcatctcca acttctccat ctacttgctc tgccagcaca tcaagcctgc caccccgcgg     1140

ccccctccta ccaccccacg gcctcctcct accaccccac agccccctcc taccactaca     1200

cagcccattc ctgacactac acagccccct cctgtcaccc caaggcctcc tcctaccacc     1260

ccacaacccc ctcctagcac agctgtcatc tgccagacag ctgtatggta cgcagtctcg     1320

tgggcaccag gtgcccgagg ttggctccaa gcctgccatg atcagtttcc tgatcaattt     1380

ctggatatga tctgcggcaa cctctcattt tcagccctgt ctggccccag tcgtcctttg     1440

gtaaagcagc tctgtgctgg cttgctccca ccccccacta gctgtccacc aggcctgatc     1500

cctgtgcccc tcaccccaga aatattctgg ggctgtttcc tggagaatga gacactgtgg     1560

gctgaacggt tgtgtgtgga ggacagtctg caggctgtgc ccccgaggaa ccaggcttgg     1620

gttcagcatg tgtgtcgggg ccccaccttg gacgccactg attttccacc gtgccgcgtt     1680

ggaccctgtg gggaacgctg cccagatggg ggcagcttcc tgctcatggt ctgtgccaat     1740

gacactctgt atgaagcctt ggttcccttc tgggcttggc tagcaggcca atgcagaatt     1800

agtcgtggag gaaatgatac ttgctttcta gaaggcatgc tgggcccctt gttgccctct     1860

ctgccccctc tgggaccatc cccactctgt ctggctcctg gtccttttct gcttggcatg     1920

ttatcccagt tgccacgctg tcagtcctcc gtgccagccc tcgcccaccc cacgcgccta     1980

cattacctcc tgcgcctact gaccttcctt ctgggtccag ggactggggg tgccgagacg     2040

caggggatgt taggtcaagc cctgctgctc tctagtctcc cagacaactg ttcattctgg     2100

gatgccttcc gcccagaggg ccggagaagt gtactgagga cagtcggaga gtacttgcag     2160

cgggaagagc caaccccacc aggcttagac tcctccctca gcctcggctc tggtatgagc     2220

aagatggagc ttctgtcctg cttcagtcct gtactgtggg atctactcca gagagagaag     2280

agcgtttggg ccctgaggac cctggtgaag gcctacctgc gcatgcctcc agaagacctt     2340

cagcagcttg tgctttcagc agagatggag gctgcacagg gcttcctgac gctcatgctt     2400

cgttcctggg ctaagctgaa ggttcaacca tccgaggagc aggccatggg ccgcctgaca     2460

gccttgctgc tccagcggta cccacgcctc acctcccaac tctttatcga catgtcaccg     2520

ctcatcccct tcctggctgt ccctgacctc atgcgcttcc caccgtccct tttggccaac     2580

gacagtgtcc tggctgccat cagggatcac agctcaggaa tgaagcctga acagaaggag     2640

gccctggcaa aacgactgct ggcccctgag ctgtttggag aagtgcctga ttggccccag     2700

gagctgctgt gggcagccct gcctctgctt ccccatctgc ctctggagag ctttctccag     2760

ctcagccctc accagatcca ggccctggag gatagctggc cagtagcaga tcttgggccg     2820

ggacacgccc gacatgtgct tcgtagccta gtaaaccaga gcatggagga tggggaggag     2880

caggtgctca ggcttgggtc cctcgcctgt ttcctgagtc ctgaggagct acagagtctg     2940

gtgcccttga gtgatccaat ggggcctgta gaacagggtc tgctggaatg tgcggccaat     3000

gggaccctca gcccagaagg acgggtggca tatgaacttc tgggagtgtt gcgttcatct     3060

ggaggaactg tcttaagccc ccgagagctg agggtctggg cacctctctt tccccagctg     3120

ggcctccgct tcctgcagga gctctcagag acccagctta gagccatgct tcctgcccta     3180

cagggagcca gtgtcacacc tgcccaggct gttctgttgt ttggaaggct ccttcctaag     3240

catgatctgt ccctggagga actctgctcc ctgcaccctc tcctgccagg tctcagcccc     3300

cagacactcc aggccatccc taagagagtt ctggttggtg cttgttcctg cctgggccct     3360

gaactgtcaa ggctttcagc ttgccagatt gcagctctgc tgcagacctt tcgggtaaaa     3420

gatggtgtta aaaatatggg tgcagcaggt gccggctcag ccgtgtgcat tcctgggcag     3480

cccaccactt ggccagactg cctgcttccc ctgctcccat taaagctgct acagctggac     3540

gctgcagctc ttctggcaaa ccgaagactc tatcggcagc tgccttggtc tgagcaacag     3600

gcacagtttc tctggaagaa aatgcaagtg cctaccaacc tgagcctgag gaatctgcag     3660

gctctgggca acttggcagg aggcatgacc tgcgagtttc tgcagcagat cagctcaatg     3720

gttgactttc ttgatgtggt acacatgctc taccagctgc ccactggtgt tcgagagagc     3780

ctgcgggcct gtatctggac agagctacag cggaggatga caatgccaga gccagagctg     3840

accaccctag ggccagaact gagtgaactt gacacaaagc tactcctgga cttgccgatc     3900

cagctgatgg acagattgtc caatgattcc attatgttgg tggtggagat ggtccaaggc     3960

gctccagagc agctgctggc actgacccca ctccaccaga cagccttggc agagcgagca     4020

cttaaaaacc tggctccaaa ggagacccca atctccaaag aagtgctgga gacactgggc     4080

cccttggttg gattcctggg aatagagagc acgcgacgga tccctttacc cattctactg     4140

tctcatctca gtcagctgca gggcttctgc ctaggagaga catttgccac agagctggga     4200

tggctgctgt tgcaggagcc tgttcttgga aaaccagaat tgtggagcca ggatgaaata     4260

gagcaagctg gacgcctagt attcactctg tctgctgagg ctatttcctc gatccccagg     4320

gaggctttgg gcccagagac actggagagg cttctgggaa agcatcaaag ctgggagcag     4380

agcagagtgg gccatctgtg tggggagtca cagcttgccc acaagaaagc agctctggta     4440

gctgggattg tgcatccagc tgctgagggt ctccaagagc ctgtaccaaa ctgtgcagac     4500

atacggggaa ccttcccagc ggcctggtct gcgacacaaa tctcagagat ggaactctca     4560

gactttgaag actgcctgtc actatttgct ggagatccag gacttggtcc tgaggaacta     4620

cgggcagcca tgggcaaggc caagcagttg tggggtcccc ctcgaggatt ccgtcctgag     4680

cagatcttgc agctgggccg tctcctgata ggtctaggag aacgggaact gcaggagctt     4740

accttggtgg actggggtgt gctgagcagc ctggggcaaa tagatggctg gagttccatg     4800

cagctccgag ccgtggtctc cagtttccta aggcagagtg gtcggcatgt gagccacctg     4860

gacttcattt atctgacagc actgggttac acagtctgtg gattgcgacc agaggagtta     4920

cagcacatca gcagttggga gtttagccaa gcagctctct tcctgggtag cttgcatctc     4980

ccgtgctctg aggaacagct ggaagttctg gcctatctcc ttgtgttgcc tggtggcttt     5040

ggcccagtca gtaactgggg gcctgagatc ttcactgaaa ttggcacaat agcagctggc     5100

atcccagacc tggctctttc agcattactg cggggacaga tccaaggcct gactcctctt     5160

gccatttctg tcattcctgc tcccaagttt gcagtggtct tcaaccccat ccagttatct     5220

agtctcacca ggggtcaggc cgtagctgtt actcctgaac agctggccta tctgagtcct     5280

gagcagcggc gagcagttgc atgggcccaa cacgaaggga aggagatccc agagcagctg     5340

ggtcgaaact cagcctgggg tctctacgac tggttccaag cctcctgggc cctggcattg     5400

cccgtcagca tttttggcca cctattatga                                      5430


<210>  8
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 
            20                  25                  30          


Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              


Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu 
                85                  90          


<210>  9
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr Asp 
1               5                   10                  15      


Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu Val 
            20                  25                  30          


Ala Ser Asn 
        35  


<210>  10
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 
            20                  25                  30          


Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              


Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 
                85                  90                  95      


Val Asp Gly Leu Pro 
            100     


<210>  11
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Met Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
1               5                   10                  15      


Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu 
            20                  25                  30          


Val Ala Ser Asn 
        35      


<210>  12
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr Asp 
1               5                   10                  15      


Ile Gly Val Gly Glu Pro His Asn Phe Leu Leu Lys Asn Gly Leu Val 
            20                  25                  30          


Ala Ser Asn 
        35  


<210>  13
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          


Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 
                85                  90                  95      


Val Asp Asn Leu Pro Asn 
            100         


<210>  14
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr 
1               5                   10                  15      


Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe 
            20                  25                  30          


Ile Ala Ser Asn 
        35      


<210>  15
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 
            20                  25                  30          


Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              


Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 
                85                  90                  95      


Val Asp Gly Leu Pro 
            100     


<210>  16
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val 
            20                  25                  30          


Tyr Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly 
        35                  40                  45              


Leu Val Ala Ser Asn 
    50              


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Cys Phe Ser Gly Asp Thr Leu Val Ala Leu Thr Asp 
1               5                   10          


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Cys Leu Ala Gly Asp Thr Leu Ile Thr Leu Ala 
1               5                   10      


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Cys Leu Gln Asn Gly Thr Arg Leu Leu Arg 
1               5                   10  


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Cys Leu Thr Gly Asp Ser Gln Val Leu Thr Arg 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Cys Leu Thr Tyr Glu Thr Glu Ile Met Thr Val 
1               5                   10      


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Cys Leu Ser Gly Asn Thr Lys Val Arg Phe Arg Tyr 
1               5                   10          


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Gly Val Phe Val His Asn 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Gly Leu Leu Val His Asn 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Gly Leu Ile Ala Ser Asn 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Gly Leu Val Val His Asn 
1               5       


<210>  27
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          


Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 
                85                  90                  95      


Val Asp Asn Leu Pro Asn 
            100         


<210>  28
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr Asp 
1               5                   10                  15      


Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe Ile 
            20                  25                  30          


Ala Ser Asn 
        35  


<210>  29
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Cys Leu Ala Gly Asp Thr Leu Ile Thr Leu Ala Asp Gly Arg Arg Val 
1               5                   10                  15      


Pro Ile Arg Glu Leu Val Ser Gln Gln Asn Phe Ser Val Trp Ala Leu 
            20                  25                  30          


Asn Pro Gln Thr Tyr Arg Leu Glu Arg Ala Arg Val Ser Arg Ala Phe 
        35                  40                  45              


Cys Thr Gly Ile Lys Pro Val Tyr Arg Leu Thr Thr Arg Leu Gly Arg 
    50                  55                  60                  


Ser Ile Arg Ala Thr Ala Asn His Arg Phe Leu Thr Pro Gln Gly Trp 
65                  70                  75                  80  


Lys Arg Val Asp Glu Leu Gln Pro Gly Asp Tyr Leu Ala Leu Pro Arg 
                85                  90                  95      


Arg Ile Pro Thr Ala Ser Thr Pro Thr Leu 
            100                 105     


<210>  30
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Ala Ala Ala Cys Pro Glu Leu Arg Gln Leu Ala Gln Ser Asp Val Tyr 
1               5                   10                  15      


Trp Asp Pro Ile Val Ser Ile Glu Pro Asp Gly Val Glu Glu Val Phe 
            20                  25                  30          


Asp Leu Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile Ile 
        35                  40                  45              


Ala His Asn 
    50      


<210>  31
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Ile Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          


Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 
65                  70                  75                  80  


Met Met Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 
                85                  90                  95      


Val Asp Asn Leu Pro Asn 
            100         


<210>  32
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe Asp 
1               5                   10                  15      


Ile Gly Leu Pro Gln Tyr His Asn Phe Leu Leu Ala Asn Gly Ala Ile 
            20                  25                  30          


Ala Ala Asn 
        35  


<210>  33
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 
            20                  25                  30          


Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              


Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 
                85                  90                  95      


Val Asp Gly Leu Pro 
            100     


<210>  34
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr Asp 
1               5                   10                  15      


Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu Val 
            20                  25                  30          


Ala Ser Asn 
        35  


<210>  35
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 
            20                  25                  30          


Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              


Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Lys Gln 
                85                  90                  95      


Val Asp Gly Leu Pro 
            100     


<210>  36
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn Val Tyr 
            20                  25                  30          


Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn Gly Leu 
        35                  40                  45              


Val Ala Ser Asn 
    50          


<210>  37
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Cys Leu Ser Phe Gly Thr Glu Ile Leu Thr Val Glu Tyr Gly Pro Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Ser Glu Glu Ile Asn Cys Ser Val Tyr Ser 
            20                  25                  30          


Val Asp Pro Glu Gly Arg Val Tyr Thr Gln Ala Ile Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Leu Glu Tyr Glu Leu Glu Asp Gly Ser 
    50                  55                  60                  


Val Ile Arg Ala Thr Ser Asp His Arg Phe Leu Thr Thr Asp Tyr Gln 
65                  70                  75                  80  


Leu Leu Ala Ile Glu Glu Ile Phe Ala Arg Gln Leu Asp Leu Leu Thr 
                85                  90                  95      


Leu Glu Asn Ile Lys Gln Thr Glu Glu Ala Leu Asp Asn His Arg Leu 
            100                 105                 110         


Pro Phe Pro Leu Leu Asp Ala Gly Thr Ile Lys 
        115                 120             


<210>  38
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Val Lys Val Ile Gly Arg Arg Ser Leu Gly Val Gln Arg Ile Phe Asp 
1               5                   10                  15      


Ile Gly Leu Pro Gln Asp His Asn Phe Leu Leu Ala Asn Gly Ala Ile 
            20                  25                  30          


Ala Ala Asn Cys 
        35      


<210>  39
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Cys Leu Ser Tyr Asp Thr Glu Ile Leu Thr Val Glu Tyr Gly Phe Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Glu Arg Ile Glu Cys Thr Val Tyr Thr 
            20                  25                  30          


Val Asp Lys Asn Gly Phe Val Tyr Thr Gln Pro Ile Ala Gln Trp His 
        35                  40                  45              


Asn Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Ile Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Thr Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Gly Leu Asp Leu Gln Val 
                85                  90                  95      


Asp 
    


<210>  40
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Gly Leu Pro Val Lys Ile Ile Ser Arg Lys Ser Leu Gly Thr Gln Asn 
1               5                   10                  15      


Val Tyr Asp Ile Gly Val Glu Lys Asp His Asn Phe Leu Leu Lys Asn 
            20                  25                  30          


Gly Leu Val Ala Ser Asn 
        35              


<210>  41
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41
tgcctgagct acgagaccga gatcctgacc gtggagtacg gcctgctgcc catcggcaag       60

atcgtggaga agagaatcga gtgcaccgtg tacagcgtgg acaacaacgg caacatctac      120

acccagcccg tggcccagtg gcacgacaga ggcgagcagg aggtgttcga gtactgcctg      180

gaggacggca gcctgatcag agccaccaag gaccacaagt tcatgaccgt ggacggccag      240

atgctgccca tcgacgagat cttcgagaga gagctggacc tgatgagagt ggacaacctg      300

cccaac                                                                 306


<210>  42
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42
atcaagatcg ccacaagaaa gtacctgggc aagcagaacg tgtacgacat cggcgtggag       60

agagaccaca acttcgccct gaagaacggc ttcatcgcca gcaat                      105


<210>  43
<211>  7561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagctagc ggcgcgccac cggtagcagg tttgttacag      240

aaaccttagt taaggtttgt tgagggtttt ttttctctct ctctctctta attggctgtc      300

ccaatccatc cttctataaa tagaaaagag agacagggag tgtgtgtggt ttcattacta      360

aggtaaagac acttgagcta cacacacttg atccctgaac atgaaatcta agaggttgaa      420

cgatcacagt ttcaggacta tataaggtgg tgaaagacca tctgcttcgt ttttctgttt      480

gttcctacaa ctctttccct ccgcttgatt ttaactctaa attggtgagt agctggtggg      540

ctcaccagac tccgagatcc tcttctctgc acgcactgta ttagacttgg cacccgggag      600

gattttcacc tctgctgcat gggctaatct tccacaaggg atctgtggta ttgcaatctc      660

gggttgatgc atgacggtga tgttgtgttt atagcatggc taaggtttag ctgcctatga      720

tgattggtta gggaaggata atttttgcta gaagattgga ctttagggaa aaaaaacccc      780

acttttattt gcttttagaa ttttaaaaga ctgggccatg tagctcaggc tggtttggag      840

ttcattatgt agtcaaggat gctcttggac tctttagcat cctcctcctc ctctttttcc      900

tcctcctcct tcttgttctt cttcttgttc ttcctcttcc ccttctcttc ccccttctct      960

ccctcttcct cctcttcctc ctccttcttg ttcttcttcc tcttcccctt ctcctctccc     1020

ccttgtcctc ctcttccttc tcctcctcct cctcttcttc tttctgagta ccaagattgc     1080

aagtgtgcac acgatgacca gcttggtctt tctttgtctt ttttttttaa cttcaatttt     1140

ggagtgaatt caagagcaac catgtagtca agaggtggct ggagtctttt ctgtatctgg     1200

gtttggttta gtactctgcc ccatcactta acaggtcctt atggccacat cttaaaaaaa     1260

ttctagagat acacggtgtc ggtgagtggc tgagaatgtg tggtcttccc atttctctgt     1320

caccgtggct cacatcttgt ttcctctgtt cggccaggta gaaaggcggc cgccatggct     1380

ctgagcctcc agccccagct gctccttctc ctgtcgctcc tgccgcagga agtgacttca     1440

gcccctactg ggcctcagtc tttggatgct ggtctctccc ttctgaagtc attcgtagcc     1500

actctggacc aagctcctca gcgttccctc agccagtcac ggttctctgc gttcctggcc     1560

aacatttctt catccttcca gcttgggagg atgggggagg gaccggtggg agagccccca     1620

cctctccagc cccctgcact tcgacttcat gatttcctcg tgacactgag aggtagccca     1680

gactgggagc caatgctagg gcttctggga gatgtgctgg cactcctggg acaggaacag     1740

actccccggg actttttggt gcaccaggca ggtgtactgg gtggacttgt agaggcattg     1800

ttgggagcgt tagttcctgg aggcccccct gcccccactc gacccccatg cacccgtgat     1860

ggcccttctg actgtgtcct ggctgctgat tggttgcctt ctctgatgtt gttattagag     1920

ggtacacgct ggcaggccct ggtgcagttg cagcccagtg tggacccaac caatgccaca     1980

ggtcttgatg gtagagagcc agctcctcac tttttacagg gtctgctggg cttgcttacc     2040

ccagcaggag agttgggctc tgaggaggct ctttggggtg gtctgctgcg cacagtgggg     2100

gcccccctct atgctgcctt ccaggagggg ctactgcgag tcactcattc tctgcaagat     2160

gaggtctttt ctattatggg acagccagag cctgatgcca gtgggcagtg ccagggaggc     2220

aaccttcaac agctgctttt atggggcatg cggaacaacc tttcttggga cgcccgagca     2280

ctgggttttc tatctggatc accacctcca ccccctgctc tcctgcactg cctgagcaga     2340

ggtgtgcctc tgcccagggc ttcccagcct gcggctcaca tcagccctcg acagcggcga     2400

gccatctctg tggaggccct ctgcgagaac cactcaggcc cagagccacc ctacagcatc     2460

tccaacttct ccatctactt gctctgccag cacatcaagc ctgccacccc gcggccccct     2520

cctaccaccc cacggcctcc tcctaccacc ccacagcccc ctcctaccac tacacagccc     2580

attcctgaca ctacacagcc ccctcctgtc accccaaggc ctcctcctac caccccacaa     2640

ccccctccta gcacagctgt catctgccag acagctgtat ggtacgcagt ctcgtgggca     2700

ccaggtgccc gaggttggct ccaagcctgc catgatcagt ttcctgatca atttctggat     2760

atgatctgcg gcaacctctc attttcagcc ctgtctggcc ccagtcgtcc tttggtaaag     2820

cagctctgtg ctggcttgct cccacccccc actagctgtc caccaggcct gatccctgtg     2880

cccctcaccc cagaaatatt ctggggctgt ttcctggaga atgagacact gtgggctgaa     2940

cggttgtgtg tggaggacag tctgcaggct gtgcccccga ggaaccaggc ttgggttcag     3000

catgtgtgtc ggggccccac cttggacgcc actgattttc caccgtgccg cgttggaccc     3060

tgtggggaac gctgcccaga tgggggcagc ttcctgctca tggtctgtgc caatgacact     3120

ctgtatgaag ccttggttcc cttctgggct tggctagcag gccaatgcag aattagtcgt     3180

ggaggaaatg atacttgctt tctagaaggc atgctgggcc ccttgttgcc ctctctgccc     3240

cctctgggac catccccact ctgtctggct cctggtcctt ttctgcttgg catgttatcc     3300

cagttgccac gctgtcagtc ctccgtgcca gccctcgccc accccacgcg cctacattac     3360

ctcctgcgcc tactgacctt ccttctgggt ccagggactg ggggtgccga gacgcagggg     3420

atgttaggtc aagccctgct gctctctagt ctcccagaca actgttcatt ctgggatgcc     3480

ttccgcccag agggccggag aagtgtactg aggacagtcg gagagtactt gcagcgggaa     3540

gagccaaccc caccaggctt agactcctcc ctcagcctcg gctctggtat gagcaagatg     3600

gagcttctgt cctgcttcag tcctgtactg tgggatctac tccagagaga gaagagcgtt     3660

tgggccctga ggaccctggt gaaggcctac ctgcgcatgc ctccagaaga ccttcagcag     3720

cttgtgcttt cagcagagat ggaggctgca cagggcttcc tgacgctcat gcttcgttcc     3780

tgggctaagc tgaaggttca accatccgag gagcaggcca tgggccgcct gacagccttg     3840

ctgctccagc ggtacccacg cctcacctcc caactcttta tcgacatgtc accgctcatc     3900

cccttcctgg ctgtccctga cctcatgcgc ttcccaccgt cccttttggc caacgacagt     3960

gtcctggctg ccatcaggga tcacagctca ggaatgaagc ctgaacagaa ggaggccctg     4020

gcaaaacgac tgctggcccc tgagctgttt ggagaagtgc ctgattggcc ccaggagctg     4080

ctgtgggcag ccctgcctct gcttccccat ctgcctctgg agagctttct ccagctcagc     4140

cctcaccaga tccaggccct ggaggatagc tggccagtag cagatcttgg gccgggacac     4200

gcccgacatg tgcttcgtag cctagtaaac cagagcatgg aggatgggga ggagcaggtg     4260

ctcaggcttg ggtccctcgc ctgtttcctg agtcctgagg agctacagag tctggtgccc     4320

ttgagtgatc caatggggcc tgtagaacag ggtctgctgg aatgtgcggc caatgggacc     4380

ctcagcccag aaggacgggt ggcatatgaa cttctgggag tgttgcgttc atctggagga     4440

actgtcttaa gcccccgaga gctgagggtc tgggcacctc tctttcccca gctgggcctc     4500

cgcttcctgc aggagctctc agagacccag cttagagcca tgcttcctgc cctacaggga     4560

gccagtgtca caccctcgag ttaagggcga attcccgata aggatcttcc tagagcatgg     4620

ctacgtagat aagtagcatg gcgggttaat cattaactac aaggaacccc tagtgatgga     4680

gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc     4740

ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gccttaatta     4800

acctaattca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca     4860

acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg     4920

caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag     4980

cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag     5040

cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt     5100

tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca     5160

cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata     5220

gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca     5280

aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc     5340

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa     5400

caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg cggaacccct     5460

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     5520

taaatgcttc aataatattg aaaaaggaag agtatgagcc atattcaacg ggaaacgtcg     5580

aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg ggctcgcgat     5640

aatgtcgggc aatcaggtgc gacaatctat cgcttgtatg ggaagcccga tgcgccagag     5700

ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga gatggtcaga     5760

ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat ccgtactcct     5820

gatgatgcat ggttactcac cactgcgatc cccggaaaaa cagcattcca ggtattagaa     5880

gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct gcgccggttg     5940

cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg tcttgctcag     6000

gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga cgagcgtaat     6060

ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt ctcaccggat     6120

tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga ggggaaatta     6180

ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga tcttgccatc     6240

ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt tcaaaaatat     6300

ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga tgagtttttc     6360

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6420

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6480

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6540

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6600

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6660

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     6720

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     6780

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     6840

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     6900

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     6960

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7020

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7080

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7140

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7200

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7260

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7320

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7380

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7440

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7500

tttcacacag gaaacagcta tgaccatgat tacgccagat ttaattaagg ccttaattag     7560

g                                                                     7561


<210>  44
<211>  7206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagctagc gcctcggctc tggtatgagc aagatggagc      240

ttctgtcctg cttcagtcct gtactgtggg atctactcca gagagagaag agcgtttggg      300

ccctgaggac cctggtgaag gcctacctgc gcatgcctcc agaagacctt cagcagcttg      360

tgctttcagc agagatggag gctgcacagg gcttcctgac gctcatgctt cgttcctggg      420

ctaagctgaa ggttcaacca tccgaggagc aggccatggg ccgcctgaca gccttgctgc      480

tccagcggta cccacgcctc acctcccaac tctttatcga catgtcaccg ctcatcccct      540

tcctggctgt ccctgacctc atgcgcttcc caccgtccct tttggccaac gacagtgtcc      600

tggctgccat cagggatcac agctcaggaa tgaagcctga acagaaggag gccctggcaa      660

aacgactgct ggcccctgag ctgtttggag aagtgcctga ttggccccag gagctgctgt      720

gggcagccct gcctctgctt ccccatctgc ctctggagag ctttctccag ctcagccctc      780

accagatcca ggccctggag gatagctggc cagtagcaga tcttgggccg ggacacgccc      840

gacatgtgct tcgtagccta gtaaaccaga gcatggagga tggggaggag caggtgctca      900

ggcttgggtc cctcgcctgt ttcctgagtc ctgaggagct acagagtctg gtgcccttga      960

gtgatccaat ggggcctgta gaacagggtc tgctggaatg tgcggccaat gggaccctca     1020

gcccagaagg acgggtggca tatgaacttc tgggagtgtt gcgttcatct ggaggaactg     1080

tcttaagccc ccgagagctg agggtctggg cacctctctt tccccagctg ggcctccgct     1140

tcctgcagga gctctcagag acccagctta gagccatgct tcctgcccta cagggagcca     1200

gtgtcacacc tgcccaggct gttctgttgt ttggaaggct ccttcctaag catgatctgt     1260

ccctggagga actctgctcc ctgcaccctc tcctgccagg tctcagcccc cagacactcc     1320

aggccatccc taagagagtt ctggttggtg cttgttcctg cctgggccct gaactgtcaa     1380

ggctttcagc ttgccagatt gcagctctgc tgcagacctt tcgggtaaaa gatggtgtta     1440

aaaatatggg tgcagcaggt gccggctcag ccgtgtgcat tcctgggcag cccaccactt     1500

ggccagactg cctgcttccc ctgctcccat taaagctgct acagctggac gctgcagctc     1560

ttctggcaaa ccgaagactc tatcggcagc tgccttggtc tgagcaacag gcacagtttc     1620

tctggaagaa aatgcaagtg cctaccaacc tgagcctgag gaatctgcag gctctgggca     1680

acttggcagg aggcatgacc tgcgagtttc tgcagcagat cagctcaatg gttgactttc     1740

ttgatgtggt acacatgctc taccagctgc ccactggtgt tcgagagagc ctgcgggcct     1800

gtatctggac agagctacag cggaggatga caatgccaga gccagagctg accaccctag     1860

ggccagaact gagtgaactt gacacaaagc tactcctgga cttgccgatc cagctgatgg     1920

acagattgtc caatgattcc attatgttgg tggtggagat ggtccaaggc gctccagagc     1980

agctgctggc actgacccca ctccaccaga cagccttggc agagcgagca cttaaaaacc     2040

tggctccaaa ggagacccca atctccaaag aagtgctgga gacactgggc cccttggttg     2100

gattcctggg aatagagagc acgcgacgga tccctttacc cattctactg tctcatctca     2160

gtcagctgca gggcttctgc ctaggagaga catttgccac agagctggga tggctgctgt     2220

tgcaggagcc tgttcttgga aaaccagaat tgtggagcca ggatgaaata gagcaagctg     2280

gacgcctagt attcactctg tctgctgagg ctatttcctc gatccccagg gaggctttgg     2340

gcccagagac actggagagg cttctgggaa agcatcaaag ctgggagcag agcagagtgg     2400

gccatctgtg tggggagtca cagcttgccc acaagaaagc agctctggta gctgggattg     2460

tgcatccagc tgctgagggt ctccaagagc ctgtaccaaa ctgtgcagac atacggggaa     2520

ccttcccagc ggcctggtct gcgacacaaa tctcagagat ggaactctca gactttgaag     2580

actgcctgtc actatttgct ggagatccag gacttggtcc tgaggaacta cgggcagcca     2640

tgggcaaggc caagcagttg tggggtcccc ctcgaggatt ccgtcctgag cagatcttgc     2700

agctgggccg tctcctgata ggtctaggag aacgggaact gcaggagctt accttggtgg     2760

actggggtgt gctgagcagc ctggggcaaa tagatggctg gagttccatg cagctccgag     2820

ccgtggtctc cagtttccta aggcagagtg gtcggcatgt gagccacctg gacttcattt     2880

atctgacagc actgggttac acagtctgtg gattgcgacc agaggagtta cagcacatca     2940

gcagttggga gtttagccaa gcagctctct tcctgggtag cttgcatctc ccgtgctctg     3000

aggaacagct ggaagttctg gcctatctcc ttgtgttgcc tggtggcttt ggcccagtca     3060

gtaactgggg gcctgagatc ttcactgaaa ttggcacaat agcagctggc atcccagacc     3120

tggctctttc agcattactg cggggacaga tccaaggcct gactcctctt gccatttctg     3180

tcattcctgc tcccaagttt gcagtggtct tcaaccccat ccagttatct agtctcacca     3240

ggggtcaggc cgtagctgtt actcctgaac agctggccta tctgagtcct gagcagcggc     3300

gagcagttgc atgggcccaa cacgaaggga aggagatccc agagcagctg ggtcgaaact     3360

cagcctgggg tctctacgac tggttccaag cctcctgggc cctggcattg cccgtcagca     3420

tttttggcca cctattatga taataagctt ggatccaatc aacctctgga ttacaaaatt     3480

tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct     3540

gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg     3600

tataaatcct ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc     3660

gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt     3720

cagctccttt ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc     3780

gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg     3840

ttgtcgggga aatcatcgtc ctttccttgg ctgctcgcct gtgttgccac ctggattctg     3900

cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc     3960

ggcctgctgc cggctctgcg gcctcttccg cgtcttcgag atctgcctcg actgtgcctt     4020

ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg     4080

ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt     4140

gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca     4200

atagcaggca tgctggggac tcgagttaag ggcgaattcc cgataaggat cttcctagag     4260

catggctacg tagataagta gcatggcggg ttaatcatta actacaagga acccctagtg     4320

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag     4380

gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagcctt     4440

aattaaccta attcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt     4500

acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag     4560

gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg ggacgcgccc     4620

tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt     4680

gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc     4740

ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta     4800

cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc     4860

tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg     4920

ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt     4980

ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat     5040

tttaacaaaa tattaacgct tacaatttag gtggcacttt tcggggaaat gtgcgcggaa     5100

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac     5160

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagccatatt caacgggaaa     5220

cgtcgaggcc gcgattaaat tccaacatgg atgctgattt atatgggtat aaatgggctc     5280

gcgataatgt cgggcaatca ggtgcgacaa tctatcgctt gtatgggaag cccgatgcgc     5340

cagagttgtt tctgaaacat ggcaaaggta gcgttgccaa tgatgttaca gatgagatgg     5400

tcagactaaa ctggctgacg gaatttatgc ctcttccgac catcaagcat tttatccgta     5460

ctcctgatga tgcatggtta ctcaccactg cgatccccgg aaaaacagca ttccaggtat     5520

tagaagaata tcctgattca ggtgaaaata ttgttgatgc gctggcagtg ttcctgcgcc     5580

ggttgcattc gattcctgtt tgtaattgtc cttttaacag cgatcgcgta tttcgtcttg     5640

ctcaggcgca atcacgaatg aataacggtt tggttgatgc gagtgatttt gatgacgagc     5700

gtaatggctg gcctgttgaa caagtctgga aagaaatgca taaacttttg ccattctcac     5760

cggattcagt cgtcactcat ggtgatttct cacttgataa ccttattttt gacgagggga     5820

aattaatagg ttgtattgat gttggacgag tcggaatcgc agaccgatac caggatcttg     5880

ccatcctatg gaactgcctc ggtgagtttt ctccttcatt acagaaacgg ctttttcaaa     5940

aatatggtat tgataatcct gatatgaata aattgcagtt tcatttgatg ctcgatgagt     6000

ttttctaact gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt     6060

tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt     6120

aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt     6180

gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag     6240

cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca     6300

gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca     6360

agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg     6420

ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg     6480

cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct     6540

acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga     6600

gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc     6660

ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg     6720

agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg     6780

cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt     6840

tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat accgctcgcc     6900

gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag cgcccaatac     6960

gcaaaccgcc tctccccgcg cgttggccga ttcattaatg cagctggcac gacaggtttc     7020

ccgactggaa agcgggcagt gagcgcaacg caattaatgt gagttagctc actcattagg     7080

caccccaggc tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat     7140

aacaatttca cacaggaaac agctatgacc atgattacgc cagatttaat taaggcctta     7200

attagg                                                                7206


<210>  45
<211>  7447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagctagc ggcgcgccac cggtagcagg tttgttacag      240

aaaccttagt taaggtttgt tgagggtttt ttttctctct ctctctctta attggctgtc      300

ccaatccatc cttctataaa tagaaaagag agacagggag tgtgtgtggt ttcattacta      360

aggtaaagac acttgagcta cacacacttg atccctgaac atgaaatcta agaggttgaa      420

cgatcacagt ttcaggacta tataaggtgg tgaaagacca tctgcttcgt ttttctgttt      480

gttcctacaa ctctttccct ccgcttgatt ttaactctaa attggtgagt agctggtggg      540

ctcaccagac tccgagatcc tcttctctgc acgcactgta ttagacttgg cacccgggag      600

gattttcacc tctgctgcat gggctaatct tccacaaggg atctgtggta ttgcaatctc      660

gggttgatgc atgacggtga tgttgtgttt atagcatggc taaggtttag ctgcctatga      720

tgattggtta gggaaggata atttttgcta gaagattgga ctttagggaa aaaaaacccc      780

acttttattt gcttttagaa ttttaaaaga ctgggccatg tagctcaggc tggtttggag      840

ttcattatgt agtcaaggat gctcttggac tctttagcat cctcctcctc ctctttttcc      900

tcctcctcct tcttgttctt cttcttgttc ttcctcttcc ccttctcttc ccccttctct      960

ccctcttcct cctcttcctc ctccttcttg ttcttcttcc tcttcccctt ctcctctccc     1020

ccttgtcctc ctcttccttc tcctcctcct cctcttcttc tttctgagta ccaagattgc     1080

aagtgtgcac acgatgacca gcttggtctt tctttgtctt ttttttttaa cttcaatttt     1140

ggagtgaatt caagagcaac catgtagtca agaggtggct ggagtctttt ctgtatctgg     1200

gtttggttta gtactctgcc ccatcactta acaggtcctt atggccacat cttaaaaaaa     1260

ttctagagat acacggtgtc ggtgagtggc tgagaatgtg tggtcttccc atttctctgt     1320

caccgtggct cacatcttgt ttcctctgtt cggccaggta gaaaggcggc cgccaccatg     1380

gctctgagcc tccagcccca gctgctcctt ctcctgtcgc tcctgccgca ggaagtgact     1440

tcagccccta ctgggcctca gtctttggat gctggtctct cccttctgaa gtcattcgta     1500

gccactctgg accaagctcc tcagcgttcc ctcagccagt cacggttctc tgcgttcctg     1560

gccaacattt cttcatcctt ccagcttggg aggatggggg agggaccggt gggagagccc     1620

ccacctctcc agccccctgc acttcgactt catgatttcc tcgtgacact gagaggtagc     1680

ccagactggg agccaatgct agggcttctg ggagatgtgc tggcactcct gggacaggaa     1740

cagactcccc gggacttttt ggtgcaccag gcaggtgtac tgggtggact tgtagaggca     1800

ttgttgggag cgttagttcc tggaggcccc cctgccccca ctcgaccccc atgcacccgt     1860

gatggccctt ctgactgtgt cctggctgct gattggttgc cttctctgat gttgttatta     1920

gagggtacac gctggcaggc cctggtgcag ttgcagccca gtgtggaccc aaccaatgcc     1980

acaggtcttg atggtagaga gccagctcct cactttttac agggtctgct gggcttgctt     2040

accccagcag gagagttggg ctctgaggag gctctttggg gtggtctgct gcgcacagtg     2100

ggggcccccc tctatgctgc cttccaggag gggctactgc gagtcactca ttctctgcaa     2160

gatgaggtct tttctattat gggacagcca gagcctgatg ccagtgggca gtgccaggga     2220

ggcaaccttc aacagctgct tttatggggc atgcggaaca acctttcttg ggacgcccga     2280

gcactgggtt ttctatctgg atcaccacct ccaccccctg ctctcctgca ctgcctgagc     2340

agaggtgtgc ctctgcccag ggcttcccag cctgcggctc acatcagccc tcgacagcgg     2400

cgagccatct ctgtggaggc cctctgcgag aaccactcag gcccagagcc accctacagc     2460

atctccaact tctccatcta cttgctctgc cagcacatca agcctgccac cccgcggccc     2520

cctcctacca ccccacggcc tcctcctacc accccacagc cccctcctac cactacacag     2580

cccattcctg acactacaca gccccctcct gtcaccccaa ggcctcctcc taccacccca     2640

caaccccctc ctagcacagc tgtcatctgc cagacagctg tatggtacgc agtctcgtgg     2700

gcaccaggtg cccgaggttg gctccaagcc tgccatgatc agtttcctga tcaatttctg     2760

gatatgatct gcggcaacct ctcattttca gccctgtctg gccccagtcg tcctttggta     2820

aagcagctct gtgctggctt gctcccaccc cccactagct gtccaccagg cctgatccct     2880

gtgcccctca ccccagaaat attctggggc tgtttcctgg agaatgagac actgtgggct     2940

gaacggttgt gtgtggagga cagtctgcag gctgtgcccc cgaggaacca ggcttgggtt     3000

cagcatgtgt gtcggggccc caccttggac gccactgatt ttccaccgtg ccgcgttgga     3060

ccctgtgggg aacgctgccc agatgggggc agcttcctgc tcatggtctg tgccaatgac     3120

actctgtatg aagccttggt tcccttctgg gcttggctag caggccaatg cagaattagt     3180

cgtggaggaa atgatacttg ctttctagaa ggcatgctgg gccccttgtt gccctctctg     3240

ccccctctgg gaccatcccc actctgtctg gctcctggtc cttttctgct tggcatgtta     3300

tcccagttgc cacgctgtca gtcctccgtg ccagccctcg cccaccccac gcgcctacat     3360

tacctcctgc gcctactgac cttccttctg ggtccaggga ctgggggtgc cgagacgcag     3420

gggatgttag gtcaagccct gctgctctct agtctcccag acaactgttc attctgggat     3480

gccttccgcc cagagggccg gagaagtgta ctgaggacag tcggagagta cttgcagcgg     3540

gaagagccaa ccccaccagg cttagactcc tccctcagcc tcggctctgg tatgagcaag     3600

atggagcttc tgtcctgctt cagtcctgta ctgtgggatc tactccagag agagaagagc     3660

gtttgggccc tgaggaccct ggtgaaggcc tacctgcgca tgcctccaga agaccttcag     3720

cagcttgtgc tttcagcaga gatggaggct gcacagggct tcctgacgct catgcttcgt     3780

tcctgggcta agctgaaggt tcaaccatcc gaggagcagg ccatgggccg cctgacagcc     3840

ttgctgctcc agcggtaccc acgcctcacc tcccaactct ttatcgacat gtcaccgctc     3900

atccccttcc tggctgtccc tgacctcatg cgcttcccac cgtccctttt ggccaacgac     3960

agtgtcctgg ctgccatcag ggatcacagc tcaggaatga agcctgaaca gaaggaggcc     4020

ctggcaaaac gactgctggc ccctgagctg tttggagaag tgcctgattg gccccaggta     4080

agtatcaagg ttacaagaca ggtttaagga gaccaataga aactgggctt gtcgagacag     4140

agaagactct tgcgtttctg agctagcccc cgggtgcgcg gcgtcggtgg tgccggcggg     4200

gggcgccagg tcgcaggcgg tgtagggctc caggcaggcg gcgaaggcca tgacgtgcgc     4260

tatgaaggtc tgctcctgca cgccgtgaac caggtgcgcc tgcgggccgc gcgcgaacac     4320

cgccacgtcc tcgcctgcgt gggtctcttc gtccaggggc actgctgact gctgccgata     4380

ctcggggctc ccgctctcgc tctcggtaac atccggccgg gcgccgtcct tgagcacata     4440

gcctggaccg tttcgtcgac ctcgagttaa gggcgaattc ccgataagga tcttcctaga     4500

gcatggctac gtagataagt agcatggcgg gttaatcatt aactacaagg aacccctagt     4560

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     4620

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagcct     4680

taattaacct aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt     4740

tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga     4800

ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc     4860

ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact     4920

tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc     4980

cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt     5040

acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc     5100

ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt     5160

gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat     5220

tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa     5280

ttttaacaaa atattaacgc ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga     5340

acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa     5400

ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagccatat tcaacgggaa     5460

acgtcgaggc cgcgattaaa ttccaacatg gatgctgatt tatatgggta taaatgggct     5520

cgcgataatg tcgggcaatc aggtgcgaca atctatcgct tgtatgggaa gcccgatgcg     5580

ccagagttgt ttctgaaaca tggcaaaggt agcgttgcca atgatgttac agatgagatg     5640

gtcagactaa actggctgac ggaatttatg cctcttccga ccatcaagca ttttatccgt     5700

actcctgatg atgcatggtt actcaccact gcgatccccg gaaaaacagc attccaggta     5760

ttagaagaat atcctgattc aggtgaaaat attgttgatg cgctggcagt gttcctgcgc     5820

cggttgcatt cgattcctgt ttgtaattgt ccttttaaca gcgatcgcgt atttcgtctt     5880

gctcaggcgc aatcacgaat gaataacggt ttggttgatg cgagtgattt tgatgacgag     5940

cgtaatggct ggcctgttga acaagtctgg aaagaaatgc ataaactttt gccattctca     6000

ccggattcag tcgtcactca tggtgatttc tcacttgata accttatttt tgacgagggg     6060

aaattaatag gttgtattga tgttggacga gtcggaatcg cagaccgata ccaggatctt     6120

gccatcctat ggaactgcct cggtgagttt tctccttcat tacagaaacg gctttttcaa     6180

aaatatggta ttgataatcc tgatatgaat aaattgcagt ttcatttgat gctcgatgag     6240

tttttctaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     6300

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     6360

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     6420

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     6480

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     6540

agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg ccaccacttc     6600

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     6660

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     6720

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     6780

tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg     6840

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     6900

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     6960

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     7020

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     7080

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     7140

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata     7200

cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt     7260

cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct cactcattag     7320

gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga     7380

taacaatttc acacaggaaa cagctatgac catgattacg ccagatttaa ttaaggcctt     7440

aattagg                                                               7447


<210>  46
<211>  6573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
ccttaattag gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctacgt      180

agccatgctc taggaagatc ggaattcgcc cttaagctag cggcgcgccc aattggcttc      240

gaattctagc ggccgccccc gggtgcgcgg cgtcggtggt gccggcgggg ggcgccaggt      300

cgcaggcggt gtagggctcc aggcaggcgg cgaaggccat gacgtgcgct atgaaggtct      360

gctcctgcac gccgtgaacc aggtgcgcct gcgggccgcg cgcgaacacc gccacgtcct      420

cgcctgcgtg ggtctcttcg tccaggggca ctgctgactg ctgccgatac tcggggctcc      480

cgctctcgct ctcggtaaca tccggccggg cgccgtcctt gagcacatag cctggaccgt      540

ttccttaagc gacgcatgct cgcgataggc acctattggt cttactgaca tccactttgc      600

ctttctctcc acaggagctg ctgtgggcag ccctgcctct gcttccccat ctgcctctgg      660

agagctttct ccagctcagc cctcaccaga tccaggccct ggaggatagc tggccagtag      720

cagatcttgg gccgggacac gcccgacatg tgcttcgtag cctagtaaac cagagcatgg      780

aggatgggga ggagcaggtg ctcaggcttg ggtccctcgc ctgtttcctg agtcctgagg      840

agctacagag tctggtgccc ttgagtgatc caatggggcc tgtagaacag ggtctgctgg      900

aatgtgcggc caatgggacc ctcagcccag aaggacgggt ggcatatgaa cttctgggag      960

tgttgcgttc atctggagga actgtcttaa gcccccgaga gctgagggtc tgggcacctc     1020

tctttcccca gctgggcctc cgcttcctgc aggagctctc agagacccag cttagagcca     1080

tgcttcctgc cctacaggga gccagtgtca cacctgccca ggctgttctg ttgtttggaa     1140

ggctccttcc taagcatgat ctgtccctgg aggaactctg ctccctgcac cctctcctgc     1200

caggtctcag cccccagaca ctccaggcca tccctaagag agttctggtt ggtgcttgtt     1260

cctgcctggg ccctgaactg tcaaggcttt cagcttgcca gattgcagct ctgctgcaga     1320

cctttcgggt aaaagatggt gttaaaaata tgggtgcagc aggtgccggc tcagccgtgt     1380

gcattcctgg gcagcccacc acttggccag actgcctgct tcccctgctc ccattaaagc     1440

tgctacagct ggacgctgca gctcttctgg caaaccgaag actctatcgg cagctgcctt     1500

ggtctgagca acaggcacag tttctctgga agaaaatgca agtgcctacc aacctgagcc     1560

tgaggaatct gcaggctctg ggcaacttgg caggaggcat gacctgcgag tttctgcagc     1620

agatcagctc aatggttgac tttcttgatg tggtacacat gctctaccag ctgcccactg     1680

gtgttcgaga gagcctgcgg gcctgtatct ggacagagct acagcggagg atgacaatgc     1740

cagagccaga gctgaccacc ctagggccag aactgagtga acttgacaca aagctactcc     1800

tggacttgcc gatccagctg atggacagat tgtccaatga ttccattatg ttggtggtgg     1860

agatggtcca aggcgctcca gagcagctgc tggcactgac cccactccac cagacagcct     1920

tggcagagcg agcacttaaa aacctggctc caaaggagac cccaatctcc aaagaagtgc     1980

tggagacact gggccccttg gttggattcc tgggaataga gagcacgcga cggatccctt     2040

tacccattct actgtctcat ctcagtcagc tgcagggctt ctgcctagga gagacatttg     2100

ccacagagct gggatggctg ctgttgcagg agcctgttct tggaaaacca gaattgtgga     2160

gccaggatga aatagagcaa gctggacgcc tagtattcac tctgtctgct gaggctattt     2220

cctcgatccc cagggaggct ttgggcccag agacactgga gaggcttctg ggaaagcatc     2280

aaagctggga gcagagcaga gtgggccatc tgtgtgggga gtcacagctt gcccacaaga     2340

aagcagctct ggtagctggg attgtgcatc cagctgctga gggtctccaa gagcctgtac     2400

caaactgtgc agacatacgg ggaaccttcc cagcggcctg gtctgcgaca caaatctcag     2460

agatggaact ctcagacttt gaagactgcc tgtcactatt tgctggagat ccaggacttg     2520

gtcctgagga actacgggca gccatgggca aggccaagca gttgtggggt ccccctcgag     2580

gattccgtcc tgagcagatc ttgcagctgg gccgtctcct gataggtcta ggagaacggg     2640

aactgcagga gcttaccttg gtggactggg gtgtgctgag cagcctgggg caaatagatg     2700

gctggagttc catgcagctc cgagccgtgg tctccagttt cctaaggcag agtggtcggc     2760

atgtgagcca cctggacttc atttatctga cagcactggg ttacacagtc tgtggattgc     2820

gaccagagga gttacagcac atcagcagtt gggagtttag ccaagcagct ctcttcctgg     2880

gtagcttgca tctcccgtgc tctgaggaac agctggaagt tctggcctat ctccttgtgt     2940

tgcctggtgg ctttggccca gtcagtaact gggggcctga gatcttcact gaaattggca     3000

caatagcagc tggcatccca gacctggctc tttcagcatt actgcgggga cagatccaag     3060

gcctgactcc tcttgccatt tctgtcattc ctgctcccaa gtttgcagtg gtcttcaacc     3120

ccatccagtt atctagtctc accaggggtc aggccgtagc tgttactcct gaacagctgg     3180

cctatctgag tcctgagcag cggcgagcag ttgcatgggc ccaacacgaa gggaaggaga     3240

tcccagagca gctgggtcga aactcagcct ggggtctcta cgactggttc caagcctcct     3300

gggccctggc attgcccgtc agcatttttg gccacctatt atgagcggcc gcggtaccaa     3360

gggcggatcc tgcatagagc tcgctgatca gcctcgactg tgccttctag ttgccagcca     3420

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc     3480

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg     3540

gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatctc     3600

gagttaaggg cgaattcccg ataaggatct tcctagagca tggctacgta gataagtagc     3660

atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc     3720

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     3780

cccgggcggc ctcagtgagc gagcgagcgc gcagccttaa ttaacctaat tcactggccg     3840

tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac ccaacttaat cgccttgcag     3900

cacatccccc tttcgccagc tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc     3960

aacagttgcg cagcctgaat ggcgaatggg acgcgccctg tagcggcgca ttaagcgcgg     4020

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc     4080

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa     4140

atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac     4200

ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt     4260

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca     4320

accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt     4380

taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta     4440

caatttaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta     4500

aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata     4560

ttgaaaaagg aagagtatga gccatattca acgggaaacg tcgaggccgc gattaaattc     4620

caacatggat gctgatttat atgggtataa atgggctcgc gataatgtcg ggcaatcagg     4680

tgcgacaatc tatcgcttgt atgggaagcc cgatgcgcca gagttgtttc tgaaacatgg     4740

caaaggtagc gttgccaatg atgttacaga tgagatggtc agactaaact ggctgacgga     4800

atttatgcct cttccgacca tcaagcattt tatccgtact cctgatgatg catggttact     4860

caccactgcg atccccggaa aaacagcatt ccaggtatta gaagaatatc ctgattcagg     4920

tgaaaatatt gttgatgcgc tggcagtgtt cctgcgccgg ttgcattcga ttcctgtttg     4980

taattgtcct tttaacagcg atcgcgtatt tcgtcttgct caggcgcaat cacgaatgaa     5040

taacggtttg gttgatgcga gtgattttga tgacgagcgt aatggctggc ctgttgaaca     5100

agtctggaaa gaaatgcata aacttttgcc attctcaccg gattcagtcg tcactcatgg     5160

tgatttctca cttgataacc ttatttttga cgaggggaaa ttaataggtt gtattgatgt     5220

tggacgagtc ggaatcgcag accgatacca ggatcttgcc atcctatgga actgcctcgg     5280

tgagttttct ccttcattac agaaacggct ttttcaaaaa tatggtattg ataatcctga     5340

tatgaataaa ttgcagtttc atttgatgct cgatgagttt ttctaactgt cagaccaagt     5400

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     5460

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     5520

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     5580

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     5640

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     5700

tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     5760

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     5820

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     5880

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     5940

gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     6000

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     6060

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     6120

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     6180

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     6240

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     6300

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     6360

ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag cgggcagtga     6420

gcgcaacgca attaatgtga gttagctcac tcattaggca ccccaggctt tacactttat     6480

gcttccggct cgtatgttgt gtggaattgt gagcggataa caatttcaca caggaaacag     6540

ctatgaccat gattacgcca gatttaatta agg                                  6573


<210>  47
<211>  865
<212>  DNA
<213>  Homo sapiens

<400>  47
ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg       60

ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg      120

aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc      180

ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt      240

aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttccgt ataggaggac      300

cgtgtaggcc ttcctgtccc gggccttgcc agcggccagc ccgatgaagg agctccctcg      360

cagggggtag cctccgaagg agaagacgtg ggagtggtcg gcagtgacga ggctcagcgt      420

gtcctcctcg ctggtgagct ggcccgccct ctcaatggcg tcgtcgaaca tgatcgtctc      480

agtcagtgcc cggtaagccc tgctttcatg atgaccatgg tcgatgcgac caccctccac      540

gaagaggaag aagccgcggg ggtgtctgct cagcaggcgc agggcagcct ctgtcatctc      600

catcagggag gggtccagtg tggagtctcg gtggatctcg tatttcatgt ctccaggctc      660

aaagagaccc atgagatggg tcacagacgg gtccagggaa gcctgcatga gctcagtgcg      720

gttccacacg taccgggcac cctggcgttc gccgagccat tcctgcacca gattcttccc      780

gtccagcctg gtcccacctt ggctgtagtc atctgggtac tcagggtctg gggttcccat      840

gcgaaacatg tactttcggc ctcca                                            865


<210>  48
<211>  437
<212>  DNA
<213>  Homo sapiens

<400>  48
ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg       60

ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg      120

aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc      180

ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt      240

aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttccgt ataggaggac      300

cgtgtaggcc ttcctgtccc gggccttgcc agcggccagc ccgatgaagg agctccctcg      360

cagggggtag cctccgaagg agaagacgtg ggagtggtcg gcagtgacga ggctcagcgt      420

gtcctcctcg ctggtga                                                     437


<210>  49
<211>  428
<212>  DNA
<213>  Homo sapiens

<400>  49
gctggcccgc cctctcaatg gcgtcgtcga acatgatcgt ctcagtcagt gcccggtaag       60

ccctgctttc atgatgacca tggtcgatgc gaccaccctc cacgaagagg aagaagccgc      120

gggggtgtct gctcagcagg cgcagggcag cctctgtcat ctccatcagg gaggggtcca      180

gtgtggagtc tcggtggatc tcgtatttca tgtctccagg ctcaaagaga cccatgagat      240

gggtcacaga cgggtccagg gaagcctgca tgagctcagt gcggttccac acgtaccggg      300

caccctggcg ttcgccgagc cattcctgca ccagattctt cccgtccagc ctggtcccac      360

cttggctgta gtcatctggg tactcagggt ctggggttcc catgcgaaac atgtactttc      420

ggcctcca                                                               428


<210>  50
<211>  287
<212>  DNA
<213>  Homo sapiens

<400>  50
ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg       60

ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg      120

aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc      180

ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt      240

aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttc                    287


<210>  51
<211>  290
<212>  DNA
<213>  Homo sapiens

<400>  51
cgtataggag gaccgtgtag gccttcctgt cccgggcctt gccagcggcc agcccgatga       60

aggagctccc tcgcaggggg tagcctccga aggagaagac gtgggagtgg tcggcagtga      120

cgaggctcag cgtgtcctcc tcgctggtga gctggcccgc cctctcaatg gcgtcgtcga      180

acatgatcgt ctcagtcagt gcccggtaag ccctgctttc atgatgacca tggtcgatgc      240

gaccaccctc cacgaagagg aagaagccgc gggggtgtct gctcagcagg                 290


<210>  52
<211>  288
<212>  DNA
<213>  Homo sapiens

<400>  52
cgcagggcag cctctgtcat ctccatcagg gaggggtcca gtgtggagtc tcggtggatc       60

tcgtatttca tgtctccagg ctcaaagaga cccatgagat gggtcacaga cgggtccagg      120

gaagcctgca tgagctcagt gcggttccac acgtaccggg caccctggcg ttcgccgagc      180

cattcctgca ccagattctt cccgtccagc ctggtcccac cttggctgta gtcatctggg      240

tactcagggt ctggggttcc catgcgaaac atgtactttc ggcctcca                   288


