                         SEQUENCE LISTING

<110>  OYSTER POINT PHARMA, INC.
 
<120>  AAV VIRION ENCODING NEUROTROPHIC FACTOR AND USES THEREOF

<130>  OYST-015/03WO 328567-2516

<150>  US 63/185,889
<151>  2021-05-07

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Met Leu Phe Tyr Thr Leu Ile Thr Ala Phe Leu Ile Gly Ile 
1               5                   10                  15      


Gln Ala Glu Pro His Ser Glu Ser Asn Val Pro Ala Gly His Thr Ile 
            20                  25                  30          


Pro Gln Val His Trp Thr Lys Leu Gln His Ser Leu Asp Thr Ala Leu 
        35                  40                  45              


Arg Arg Ala Arg Ser Ala Pro Ala Ala Ala Ile Ala Ala Arg Val Ala 
    50                  55                  60                  


Gly Gln Thr Arg Asn Ile Thr Val Asp Pro Arg Leu Phe Lys Lys Arg 
65                  70                  75                  80  


Arg Leu Arg Ser Pro Arg Val Leu Phe Ser Thr Gln Pro Pro Arg Glu 
                85                  90                  95      


Ala Ala Asp Thr Gln Asp Leu Asp Phe Glu Val Gly Gly Ala Ala Pro 
            100                 105                 110         


Phe Asn Arg Thr His Arg Ser Lys Arg Ser Ser Ser His Pro Ile Phe 
        115                 120                 125             


His Arg Gly Glu Phe Ser Val Cys Asp Ser Val Ser Val Trp Val Gly 
    130                 135                 140                 


Asp Lys Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu Val Met Val Leu 
145                 150                 155                 160 


Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln Tyr Phe Phe Glu 
                165                 170                 175     


Thr Lys Cys Arg Asp Pro Asn Pro Val Asp Ser Gly Cys Arg Gly Ile 
            180                 185                 190         


Asp Ser Lys His Trp Asn Ser Tyr 
        195                 200 


<210>  2
<211>  726
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtccatgt tgttctacac tctgatcaca gcttttctga tcggcataca ggcggaacca       60

cactcagaga gcaatgtccc tgcaggacac accatccccc aagtccactg gactaaactt      120

cagcattccc ttgacactgc ccttcgcaga gcccgcagcg ccccggcagc ggcgatagct      180

gcacgcgtgg cggggcagac ccgcaacatt actgtggacc ccaggctgtt taaaaagcgg      240

cgactccgtt caccccgtgt gctgtttagc acccagcctc cccgtgaagc tgcagacact      300

caggatctgg acttcgaggt cggtggtgct gcccccttca acaggactca caggagcaag      360

cggtcatcat cccatcccat cttccacagg ggcgaattct cggtgtgtga cagtgtcagc      420

gtgtgggttg gggataagac caccgccaca gacatcaagg gcaaggaggt gatggtgttg      480

ggagaggtga acattaacaa cagtgtattc aaacagtact tttttgagac caagtgccgg      540

gacccaaatc ccgttgacag cgggtgccgg ggcattgact caaagcactg gaactcatat      600

tgtaccacga ctcacacctt tgtcaaggcg ctgaccatgg atggcaagca ggctgcctgg      660

cggtttatcc ggatagatac ggcctgtgtg tgtgtgctca gcaggaaggc tgtgagaaga      720

gcctga                                                                 726


<210>  3
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  4
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  4
atgaagttat gggatgtcgt ggctgtctgc ctggtgctgc tccacaccgc gtccgccttc       60

ccgctgcccg ccggtaagag gcctcccgag gcgcccgccg aagaccgctc cctcggccgc      120

cgccgcgcgc ccttcgcgct gagcagtgac tcaaatatgc cagaggatta tcctgatcag      180

ttcgatgatg tcatggattt tattcaagcc accattaaaa gactgaaaag gtcaccagat      240

aaacaaatgg cagtgcttcc tagaagagag cggaatcggc aggctgcagc tgccaaccca      300

gagaattcca gaggaaaagg tcggagaggc cagaggggca aaaaccgggg ttgtgtctta      360

actgcaatac atttaaatgt cactgacttg ggtctgggct atgaaaccaa ggaggaactg      420

atttttaggt actgcagcgg ctcttgcgat gcagctgaga caacgtacga caaaatattg      480

aaaaacttat ccagaaatag aaggctggtg agtgacaaag tagggcaggc atgttgcaga      540

cccatcgcct ttgatgatga cctgtcgttt ttagatgata acctggttta ccatattcta      600

agaaagcatt ccgctaaaag gtgtggatgt atctga                                636


<210>  5
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CAG Promoter

<400>  5
ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc       60

aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt      120

ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac      180

gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac      240

cttatgggac tttcctactt ggcagtacat ctactcgagg ccacgttctg cttcactctc      300

cccatctccc ccccctcccc acccccaatt ttgtatttat ttatttttta attattttgt      360

gcagcgatgg gggcgggggg gggggggggg cgcgcgccag gcggggcggg gcggggcgag      420

gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg cgcgctccga      480

aagtttcctt ttatggcgag gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg      540

cgggcgggag cgggatcagc caccgcggtg gcggcctaga gtcgacgagg aactgaaaaa      600

ccagaaagtt aactg                                                       615


<210>  6
<211>  735
<212>  PRT
<213>  Dependoparvovirus adeno-associated dependoparvovirus A

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  7
<211>  2208
<212>  DNA
<213>  Dependoparvovirus adeno-associated dependoparvovirus A

<400>  7
atggctgccg atggttatct tccagattgg ctcgaggaca ctctctctga aggaataaga       60

cagtggtgga agctcaaacc tggcccacca ccaccaaagc ccgcagagcg gcataaggac      120

gacagcaggg gtcttgtgct tcctgggtac aagtacctcg gacccttcaa cggactcgac      180

aagggagagc cggtcaacga ggcagacgcc gcggccctcg agcacgacaa agcctacgac      240

cggcagctcg acagcggaga caacccgtac ctcaagtaca accacgccga cgcggagttt      300

caggagcgcc ttaaagaaga tacgtctttt gggggcaacc tcggacgagc agtcttccag      360

gcgaaaaaga gggttcttga acctctgggc ctggttgagg aacctgttaa gacggctccg      420

ggaaaaaaga ggccggtaga gcactctcct gtggagccag actcctcctc gggaaccgga      480

aaggcgggcc agcagcctgc aagaaaaaga ttgaattttg gtcagactgg agacgcagac      540

tcagtacctg acccccagcc tctcggacag ccaccagcag ccccctctgg tctgggaact      600

aatacgatgg ctacaggcag tggcgcacca atggcagaca ataacgaggg cgccgacgga      660

gtgggtaatt cctcgggaaa ttggcattgc gattccacat ggatgggcga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca accacctcta caaacaaatt      780

tccagccaat caggagcctc gaacgacaat cactactttg gctacagcac cccttggggg      840

tattttgact tcaacagatt ccactgccac ttttcaccac gtgactggca aagactcatc      900

aacaacaact ggggattccg acccaagaga ctcaacttca agctctttaa cattcaagtc      960

aaagaggtca cgcagaatga cggtacgacg acgattgcca ataaccttac cagcacggtt     1020

caggtgttta ctgactcgga gtaccagctc ccgtacgtcc tcggctcggc gcatcaagga     1080

tgcctcccgc cgttcccagc agacgtcttc atggtgccac agtatggata cctcaccctg     1140

aacaacggga gtcaggcagt aggacgctct tcattttact gcctggagta ctttccttct     1200

cagatgctgc gtaccggaaa caactttacc ttcagctaca cttttgagga cgttcctttc     1260

cacagcagct acgctcacag ccagagtctg gaccgtctca tgaatcctct catcgaccag     1320

tacctgtatt acttgagcag aacaaacact ccaagtggaa ccaccacgca gtcaaggctt     1380

cagttttctc aggccggagc gagtgacatt cgggaccagt ctaggaactg gcttcctgga     1440

ccctgttacc gccagcagcg agtatcaaag acatctgcgg ataacaacaa cagtgaatac     1500

tcgtggactg gagctaccaa gtaccacctc aatggcagag actctctggt gaatccgggc     1560

ccggccatgg caagccacaa ggacgatgaa gaaaagtttt ttcctcagag cggggttctc     1620

atctttggga agcaaggctc agagaaaaca aatgtggaca ttgaaaaggt catgattaca     1680

gacgaagagg aaatcaggac aaccaatccc gtggctacgg agcagtatgg ttctgtatct     1740

accaacctcc agagaggcaa cagacaagca gctaccgcag atgtcaacac acaaggcgtt     1800

cttccaggca tggtctggca ggacagagat gtgtaccttc aggggcccat ctgggcaaag     1860

attccacaca cggacggaca ttttcacccc tctcccctca tgggtggatt cggacttaaa     1920

caccctcctc cacagattct catcaagaac accccggtac ctgcgaatcc ttcgaccacc     1980

ttcagtgcgg caaagtttgc ttccttcatc acacagtact ccacgggaca ggtcagcgtg     2040

gagatcgagt gggagctgca gaaggaaaac agcaaacgct ggaatcccga aattcagtac     2100

acttccaact acaacaagtc tgttaatgtg gactttactg tggacactaa tggcgtgtat     2160

tcagagcctc gccccattgg caccagatac ctgactcgta atctgtaa                  2208


<210>  8
<211>  533
<212>  PRT
<213>  Dependoparvovirus adeno-associated dependoparvovirus A

<400>  8

Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala 
    50                  55                  60                  


Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe 
65                  70                  75                  80  


Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
                85                  90                  95      


Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys 
            100                 105                 110         


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr 
        115                 120                 125             


Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser 
    130                 135                 140                 


Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu 
145                 150                 155                 160 


Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu 
                165                 170                 175     


Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys 
            180                 185                 190         


Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr 
        195                 200                 205             


Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His 
    210                 215                 220                 


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu 
225                 230                 235                 240 


Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser 
                245                 250                 255     


Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser 
            260                 265                 270         


Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys 
        275                 280                 285             


Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr 
    290                 295                 300                 


Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala 
305                 310                 315                 320 


Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile 
            340                 345                 350         


Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro 
        355                 360                 365             


Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly 
    370                 375                 380                 


Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro 
385                 390                 395                 400 


Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
                405                 410                 415     


Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met 
            420                 425                 430         


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn 
        435                 440                 445             


Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe 
    450                 455                 460                 


Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile 
465                 470                 475                 480 


Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
                485                 490                 495     


Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val 
            500                 505                 510         


Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr 
        515                 520                 525             


Leu Thr Arg Asn Leu 
    530             


<210>  9
<211>  1602
<212>  DNA
<213>  Dependoparvovirus adeno-associated dependoparvovirus A

<400>  9
atggctacag gcagtggcgc accaatggca gacaataacg agggcgccga cggagtgggt       60

aattcctcgg gaaattggca ttgcgattcc acatggatgg gcgacagagt catcaccacc      120

agcacccgaa cctgggccct gcccacctac aacaaccacc tctacaaaca aatttccagc      180

caatcaggag cctcgaacga caatcactac tttggctaca gcaccccttg ggggtatttt      240

gacttcaaca gattccactg ccacttttca ccacgtgact ggcaaagact catcaacaac      300

aactggggat tccgacccaa gagactcaac ttcaagctct ttaacattca agtcaaagag      360

gtcacgcaga atgacggtac gacgacgatt gccaataacc ttaccagcac ggttcaggtg      420

tttactgact cggagtacca gctcccgtac gtcctcggct cggcgcatca aggatgcctc      480

ccgccgttcc cagcagacgt cttcatggtg ccacagtatg gatacctcac cctgaacaac      540

gggagtcagg cagtaggacg ctcttcattt tactgcctgg agtactttcc ttctcagatg      600

ctgcgtaccg gaaacaactt taccttcagc tacacttttg aggacgttcc tttccacagc      660

agctacgctc acagccagag tctggaccgt ctcatgaatc ctctcatcga ccagtacctg      720

tattacttga gcagaacaaa cactccaagt ggaaccacca cgcagtcaag gcttcagttt      780

tctcaggccg gagcgagtga cattcgggac cagtctagga actggcttcc tggaccctgt      840

taccgccagc agcgagtatc aaagacatct gcggataaca acaacagtga atactcgtgg      900

actggagcta ccaagtacca cctcaatggc agagactctc tggtgaatcc gggcccggcc      960

atggcaagcc acaaggacga tgaagaaaag ttttttcctc agagcggggt tctcatcttt     1020

gggaagcaag gctcagagaa aacaaatgtg gacattgaaa aggtcatgat tacagacgaa     1080

gaggaaatca ggacaaccaa tcccgtggct acggagcagt atggttctgt atctaccaac     1140

ctccagagag gcaacagaca agcagctacc gcagatgtca acacacaagg cgttcttcca     1200

ggcatggtct ggcaggacag agatgtgtac cttcaggggc ccatctgggc aaagattcca     1260

cacacggacg gacattttca cccctctccc ctcatgggtg gattcggact taaacaccct     1320

cctccacaga ttctcatcaa gaacaccccg gtacctgcga atccttcgac caccttcagt     1380

gcggcaaagt ttgcttcctt catcacacag tactccacgg gacaggtcag cgtggagatc     1440

gagtgggagc tgcagaagga aaacagcaaa cgctggaatc ccgaaattca gtacacttcc     1500

aactacaaca agtctgttaa tgtggacttt actgtggaca ctaatggcgt gtattcagag     1560

cctcgcccca ttggcaccag atacctgact cgtaatctgt aa                        1602


<210>  10
<211>  724
<212>  PRT
<213>  Dependoparvovirus adeno-associated dependoparvovirus A

<400>  10

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  11
<211>  2175
<212>  DNA
<213>  Dependoparvovirus adeno-associated dependoparvovirus A

<400>  11
atgtcttttg ttgatcaccc tccagattgg ttggaagaag ttggtgaagg tcttcgcgag       60

tttttgggcc ttgaagcggg cccaccgaaa ccaaaaccca atcagcagca tcaagatcaa      120

gcccgtggtc ttgtgctgcc tggttataac tatctcggac ccggaaacgg tctcgatcga      180

ggagagcctg tcaacagggc agacgaggtc gcgcgagagc acgacatctc gtacaacgag      240

cagcttgagg cgggagacaa cccctacctc aagtacaacc acgcggacgc cgagtttcag      300

gagaagctcg ccgacgacac atccttcggg ggaaacctcg gaaaggcagt ctttcaggcc      360

aagaaaaggg ttctcgaacc ttttggcctg gttgaagagg gtgctaagac ggcccctacc      420

ggaaagcgga tagacgacca ctttccaaaa agaaagaagg ctcggaccga agaggactcc      480

aagccttcca cctcgtcaga cgccgaagct ggacccagcg gatcccagca gctgcaaatc      540

ccagcccaac cagcctcaag tttgggagct gatacaatgt ctgcgggagg tggcggccca      600

ttgggcgaca ataaccaagg tgccgatgga gtgggcaatg cctcgggaga ttggcattgc      660

gattccacgt ggatggggga cagagtcgtc accaagtcca cccgaacctg ggtgctgccc      720

agctacaaca accaccagta ccgagagatc aaaagcggct ccgtcgacgg aagcaacgcc      780

aacgcctact ttggatacag caccccctgg gggtactttg actttaaccg cttccacagc      840

cactggagcc cccgagactg gcaaagactc atcaacaact actggggctt cagaccccgg      900

tccctcagag tcaaaatctt caacattcaa gtcaaagagg tcacggtgca ggactccacc      960

accaccatcg ccaacaacct cacctccacc gtccaagtgt ttacggacga cgactaccag     1020

ctgccctacg tcgtcggcaa cgggaccgag ggatgcctgc cggccttccc tccgcaggtc     1080

tttacgctgc cgcagtacgg ttacgcgacg ctgaaccgcg acaacacaga aaatcccacc     1140

gagaggagca gcttcttctg cctagagtac tttcccagca agatgctgag aacgggcaac     1200

aactttgagt ttacctacaa ctttgaggag gtgcccttcc actccagctt cgctcccagt     1260

cagaacctgt tcaagctggc caacccgctg gtggaccagt acttgtaccg cttcgtgagc     1320

acaaataaca ctggcggagt ccagttcaac aagaacctgg ccgggagata cgccaacacc     1380

tacaaaaact ggttcccggg gcccatgggc cgaacccagg gctggaacct gggctccggg     1440

gtcaaccgcg ccagtgtcag cgccttcgcc acgaccaata ggatggagct cgagggcgcg     1500

agttaccagg tgcccccgca gccgaacggc atgaccaaca acctccaggg cagcaacacc     1560

tatgccctgg agaacactat gatcttcaac agccagccgg cgaacccggg caccaccgcc     1620

acgtacctcg agggcaacat gctcatcacc agcgagagcg agacgcagcc ggtgaaccgc     1680

gtggcgtaca acgtcggcgg gcagatggcc accaacaacc agagctccac cactgccccc     1740

gcgaccggca cgtacaacct ccaggaaatc gtgcccggca gcgtgtggat ggagagggac     1800

gtgtacctcc aaggacccat ctgggccaag atcccagaga cgggggcgca ctttcacccc     1860

tctccggcca tgggcggatt cggactcaaa cacccaccgc ccatgatgct catcaagaac     1920

acgcctgtgc ccggaaatat caccagcttc tcggacgtgc ccgtcagcag cttcatcacc     1980

cagtacagca ccgggcaggt caccgtggag atggagtggg agctcaagaa ggaaaactcc     2040

aagaggtgga acccagagat ccagtacaca aacaactaca acgaccccca gtttgtggac     2100

tttgccccgg acagcaccgg ggaatacaga accaccagac ctatcggaac ccgatacctt     2160

acccgacccc tttaa                                                      2175


<210>  12
<211>  738
<212>  PRT
<213>  Dependoparvovirus adeno-associated dependoparvovirus A

<400>  12

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  13
<211>  2214
<212>  DNA
<213>  Dependoparvovirus adeno-associated dependoparvovirus A

<400>  13
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac      120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc      480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca      540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga      600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac      960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc     1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc     1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac     1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac     1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac     1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg     1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg     1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg     1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat     1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct     1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac     1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc     1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt     1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc     1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt     1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct     1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag     2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag     2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa     2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctg           2214


<210>  14
<211>  736
<212>  PRT
<213>  Dependoparvovirus adeno-associated dependoparvovirus A

<400>  14

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  15
<211>  2209
<212>  DNA
<213>  Dependoparvovirus adeno-associated dependoparvovirus A

<400>  15
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgt                 2209


<210>  16
<211>  613
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CMV Promoter

<400>  16
ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc       60

gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      120

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      180

aatgggtgga ctatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      240

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      300

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      360

ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg      420

gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac      480

gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg      540

tacggtggga ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact      600

ggcttatcga aat                                                         613


<210>  17
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Codon optimized NGF

<400>  17
atgagcatgc tgttttacac cctgatcacc gccttcctga tcggcatcca ggccgagccc       60

cacagcgaga gcaacgtgcc cgctggacac acaatccctc aggcccactg gacaaaactg      120

cagcatagcc tggatacagc cctgagaagg gccagaagcg cccctgccgc cgccatcgcc      180

gctagagtgg ccggccagac aagaaatatc accgtggacc cccggctgtt caagaaaaga      240

agactgcggt ctcctagagt gctcttttca acacagcctc ctcgggaagc cgctgatacc      300

caggacctgg acttcgaggt gggaggcgcc gctcctttca atagaaccca cagatccaag      360

agaagctcta gccaccctat cttccaccgg ggcgagttca gcgtgtgcga cagcgtttct      420

gtgtgggtgg gagataagac caccgcaacc gatatcaagg gcaaggaagt gatggtgctg      480

ggcgaagtga acatcaacaa cagcgtcttt aagcagtact tcttcgagac aaagtgccgg      540

gacccaaacc ccgtggacag cggctgcaga ggcattgact ccaagcactg gaactcctac      600

tgcaccacaa cacacacctt cgtgaaggcc ctgaccatgg acggcaaaca agctgcctgg      660

cggttcatca gaatcgacac cgcctgtgtc tgtgtgctga gcagaaaggc cgtgcgccgg      720

gcctag                                                                 726


<210>  18
<211>  635
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Codon Optimized GDNF

<400>  18
atgaactgtg ggacgttgtg gccgtgtgcc tggtcctcct gcacaccgcc tccgcctttc       60

cactgcctgc tggaaagcgg cctcctgagg cccctgctga agatagaagc ctgggcagaa      120

gaagagcccc cttcgccctg agctctgata gcaacatgcc tgaggactac cccgaccagt      180

tcgacgacgt gatggacttt atccaggcca ccatcaagag actgaaacgg agccctgaca      240

agcagatggc cgtgctgcct agacgggaaa gaaatagaca ggccgcagct gccaaccccg      300

agaacagcag aggcaaaggc cggagaggcc agaggggaaa aaacagagga tgtgtgctga      360

ccgccatcca tctgaacgtg acagatctgg gcctgggcta tgagaccaag gaagagctga      420

tcttcagata ctgcagcggc agctgcgacg ccgccgagac aacctacgac aagatcctga      480

agaacctgtc ccggaatcgg cggctggtgt ctgacaaggt gggccaagct tgctgcagac      540

caattgcctt cgacgatgat ctgtctttcc tggatgacaa cctggtgtac cacatcctga      600

gaaagcacag cgccaagcgc tgcggctgta tctag                                 635


<210>  19
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  5' ITR Sequence

<400>  19
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaac                                            145


<210>  20
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  3' ITR Sequence

<400>  20
gttaatcatt aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc       60

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc      120

ggcctcagtg agcgagcgag cgcgc                                            145


<210>  21
<211>  228
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  bGHpolyA Sequence

<400>  21
cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga       60

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt      120

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg      180

attgggaaga caatagcagg catgctgggg atgcggtggg ctctatgg                   228


<210>  22
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  WPRE Sequence

<400>  22
tcctgttaat caacctctgg attacaaaat ttgtgaaaga ttgactgata ttcttaacta       60

tgttgctcct tttacgctgt gtggatatgc tgctttaatg cctctgtatc atgctattgc      120

ttcccgtacg gctttcgttt tctcctcctt gtataaatcc tggttgctgt ctctttatga      180

ggagttgtgg cccgttgtcc gtcaacgtgg cgtggtgtgc tctgtgtttg ctgacgcaac      240

ccccactggc tggggcattg ccaccacctg tcaactcctt tctgggactt tcgctttccc      300

cctccctatc gccacggcag aactcatcgc cgcctgcctt gcccgctgct ggacaggggc      360

taggttgctg ggcactgata attccgtggt gttgtcgggg aagctgacgt c               411


<210>  23
<211>  2967
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Expression cassette comprising sequence encoding GDNF

<400>  23
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacggatc tttacaaatt caagccaggt gatttcaaca      180

aattttgctg acgatttagg cgcactatcc cctaaactac aaattagaaa atagcgttcc      240

ttgacactag tctagttatt aatagtaatc aattacgggg tcattagttc atagcccata      300

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      360

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      420

ccattgacgt caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt      480

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      540

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      600

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      660

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca      720

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg      780

cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc      840

cactgcttac tggcttatcg aaataagctt tctcagggga gatctcgttt agtgaaccgt      900

cagatcctca ctctcttccg catcgctgtc tgcgagggcc agctgttggg ctcgcggttg      960

aggacaaact cttcgcggtc tttccagtac tcttggatcg gaaacccgtc ggcctccgaa     1020

cggtactccg ccaccgaggg acctgagcga gtccgcatcg accggatcgg aaaacctctc     1080

gagaaaggcg tctaaccagt cacagtcgca aggtaggctg agcaccgtgg cgggcggcag     1140

cgggtggcgg tcggggttgt ttctggcgga ggtgctgctg atgatgtaat taaagtaggc     1200

ggtcttgaga cggcggatgg tcgaggtgag gtgtggcagg cttgagatcc agctgttggg     1260

gtgagtactc cctctcaaaa gcgggcatta cttctgcgct aagattgtca gtttccaaaa     1320

acgaggagga tttgatattc acctggcccg atctggccat acacttgagt gacaatgaca     1380

tccactttgc ctttctctcc acaggtgtcc actcccaggt ccaagtttaa acgccgccgc     1440

catgaagctg tgggacgttg tggccgtgtg cctggtcctc ctgcacaccg cctccgcctt     1500

tccactgcct gctggaaagc ggcctcctga ggcccctgct gaagatagaa gcctgggcag     1560

aagaagagcc cccttcgccc tgagctctga tagcaacatg cctgaggact accccgacca     1620

gttcgacgac gtgatggact ttatccaggc caccatcaag agactgaaac ggagccctga     1680

caagcagatg gccgtgctgc ctagacggga aagaaataga caggccgcag ctgccaaccc     1740

cgagaacagc agaggcaaag gccggagagg ccagagggga aaaaacagag gatgtgtgct     1800

gaccgccatc catctgaacg tgacagatct gggcctgggc tatgagacca aggaagagct     1860

gatcttcaga tactgcagcg gcagctgcga cgccgccgag acaacctacg acaagatcct     1920

gaagaacctg tcccggaatc ggcggctggt gtctgacaag gtgggccaag cttgctgcag     1980

accaattgcc ttcgacgatg atctgtcttt cctggatgac aacctggtgt accacatcct     2040

gagaaagcac agcgccaagc gctgcggctg tatctagtcc tgttaatcaa cctctggatt     2100

acaaaatttg tgaaagattg actgatattc ttaactatgt tgctcctttt acgctgtgtg     2160

gatatgctgc tttaatgcct ctgtatcatg ctattgcttc ccgtacggct ttcgttttct     2220

cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc gttgtccgtc     2280

aacgtggcgt ggtgtgctct gtgtttgctg acgcaacccc cactggctgg ggcattgcca     2340

ccacctgtca actcctttct gggactttcg ctttccccct ccctatcgcc acggcagaac     2400

tcatcgccgc ctgccttgcc cgctgctgga caggggctag gttgctgggc actgataatt     2460

ccgtggtgtt gtcggggaag ctgacgtccg actgtgcctt ctagttgcca gccatctgtt     2520

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     2580

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     2640

ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat     2700

gcggtgggct ctatggagcg ctggctagaa ttacctaccg gcctccacca taccttcgat     2760

attcgcgccc actctcccat taatccgcac aagtggatgt gatgcgattg cccgctaaga     2820

tagttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc     2880

gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg     2940

gcggcctcag tgagcgagcg agcgcgc                                         2967


<210>  24
<211>  3054
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Expression cassette comprising sequence encoding NGF

<400>  24
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacggatc tttacaaatt caagccaggt gatttcaaca      180

aattttgctg acgatttagg cgcactatcc cctaaactac aaattagaaa atagcgttcc      240

ttgacactag tctagttatt aatagtaatc aattacgggg tcattagttc atagcccata      300

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      360

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      420

ccattgacgt caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt      480

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      540

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      600

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      660

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca      720

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg      780

cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc      840

cactgcttac tggcttatcg aaataagctt tctcagggga gatctcgttt agtgaaccgt      900

cagatcctca ctctcttccg catcgctgtc tgcgagggcc agctgttggg ctcgcggttg      960

aggacaaact cttcgcggtc tttccagtac tcttggatcg gaaacccgtc ggcctccgaa     1020

cggtactccg ccaccgaggg acctgagcga gtccgcatcg accggatcgg aaaacctctc     1080

gagaaaggcg tctaaccagt cacagtcgca aggtaggctg agcaccgtgg cgggcggcag     1140

cgggtggcgg tcggggttgt ttctggcgga ggtgctgctg atgatgtaat taaagtaggc     1200

ggtcttgaga cggcggatgg tcgaggtgag gtgtggcagg cttgagatcc agctgttggg     1260

gtgagtactc cctctcaaaa gcgggcatta cttctgcgct aagattgtca gtttccaaaa     1320

acgaggagga tttgatattc acctggcccg atctggccat acacttgagt gacaatgaca     1380

tccactttgc ctttctctcc acaggtgtcc actcccaggt ccaagtttaa acgccgccgc     1440

catgagcatg ctgttttaca ccctgatcac cgccttcctg atcggcatcc aggccgagcc     1500

ccacagcgag agcaacgtgc ccgctggaca cacaatccct caggcccact ggacaaaact     1560

gcagcatagc ctggatacag ccctgagaag ggccagaagc gcccctgccg ccgccatcgc     1620

cgctagagtg gccggccaga caagaaatat caccgtggac ccccggctgt tcaagaaaag     1680

aagactgcgg tctcctagag tgctcttttc aacacagcct cctcgggaag ccgctgatac     1740

ccaggacctg gacttcgagg tgggaggcgc cgctcctttc aatagaaccc acagatccaa     1800

gagaagctct agccacccta tcttccaccg gggcgagttc agcgtgtgcg acagcgtttc     1860

tgtgtgggtg ggagataaga ccaccgcaac cgatatcaag ggcaaggaag tgatggtgct     1920

gggcgaagtg aacatcaaca acagcgtctt taagcagtac ttcttcgaga caaagtgccg     1980

ggacccaaac cccgtggaca gcggctgcag aggcattgac tccaagcact ggaactccta     2040

ctgcaccaca acacacacct tcgtgaaggc cctgaccatg gacggcaaac aagctgcctg     2100

gcggttcatc agaatcgaca ccgcctgtgt ctgtgtgctg agcagaaagg ccgtgcgccg     2160

ggcctagtcc tgttaatcaa cctctggatt acaaaatttg tgaaagattg actgatattc     2220

ttaactatgt tgctcctttt acgctgtgtg gatatgctgc tttaatgcct ctgtatcatg     2280

ctattgcttc ccgtacggct ttcgttttct cctccttgta taaatcctgg ttgctgtctc     2340

tttatgagga gttgtggccc gttgtccgtc aacgtggcgt ggtgtgctct gtgtttgctg     2400

acgcaacccc cactggctgg ggcattgcca ccacctgtca actcctttct gggactttcg     2460

ctttccccct ccctatcgcc acggcagaac tcatcgccgc ctgccttgcc cgctgctgga     2520

caggggctag gttgctgggc actgataatt ccgtggtgtt gtcggggaag ctgacgtccg     2580

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     2640

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     2700

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     2760

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggagcg ctggctagaa     2820

ttacctaccg gcctccacca taccttcgat attcgcgccc actctcccat taatccgcac     2880

aagtggatgt gatgcgattg cccgctaaga tagttaatca ttaactacaa ggaaccccta     2940

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca     3000

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcg           3054


<210>  25
<211>  5895
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  pAAV-CMVE-NGF

<400>  25
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt gacgcgtatt gggattgacc      420

taacgaaaag tgaacttcat aatacgtgct gtcccacgca catggtagat ttggacaaaa      480

ttgaatggag tctgatcaac cttcacaccg atctagatat cgcgcgctcg ctcgctcact      540

gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc      600

gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctt gtagttaatg      660

attaacggat ctttacaaat tcaagccagg tgatttcaac aaattttgct gacgatttag      720

gcgcactatc ccctaaacta caaattagaa aatagcgttc cttgacacta gtctagttat      780

taatagtaat caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca      840

taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca      900

ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg      960

gactatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg     1020

ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc     1080

ttatgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg     1140

atgcggtttt ggcagtacat caatgggcgt ggatagcggt ttgactcacg gggatttcca     1200

agtctccacc ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt     1260

ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg     1320

gaggtctata taagcagagc tctctggcta actagagaac ccactgctta ctggcttatc     1380

gaaataagct ttctcagggg agatctcgtt tagtgaaccg tcagatcctc actctcttcc     1440

gcatcgctgt ctgcgagggc cagctgttgg gctcgcggtt gaggacaaac tcttcgcggt     1500

ctttccagta ctcttggatc ggaaacccgt cggcctccga acggtactcc gccaccgagg     1560

gacctgagcg agtccgcatc gaccggatcg gaaaacctct cgagaaaggc gtctaaccag     1620

tcacagtcgc aaggtaggct gagcaccgtg gcgggcggca gcgggtggcg gtcggggttg     1680

tttctggcgg aggtgctgct gatgatgtaa ttaaagtagg cggtcttgag acggcggatg     1740

gtcgaggtga ggtgtggcag gcttgagatc cagctgttgg ggtgagtact ccctctcaaa     1800

agcgggcatt acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt     1860

cacctggccc gatctggcca tacacttgag tgacaatgac atccactttg cctttctctc     1920

cacaggtgtc cactcccagg tccaagttta aacgccgccg ccatgagcat gctgttttac     1980

accctgatca ccgccttcct gatcggcatc caggccgagc cccacagcga gagcaacgtg     2040

cccgctggac acacaatccc tcaggcccac tggacaaaac tgcagcatag cctggataca     2100

gccctgagaa gggccagaag cgcccctgcc gccgccatcg ccgctagagt ggccggccag     2160

acaagaaata tcaccgtgga cccccggctg ttcaagaaaa gaagactgcg gtctcctaga     2220

gtgctctttt caacacagcc tcctcgggaa gccgctgata cccaggacct ggacttcgag     2280

gtgggaggcg ccgctccttt caatagaacc cacagatcca agagaagctc tagccaccct     2340

atcttccacc ggggcgagtt cagcgtgtgc gacagcgttt ctgtgtgggt gggagataag     2400

accaccgcaa ccgatatcaa gggcaaggaa gtgatggtgc tgggcgaagt gaacatcaac     2460

aacagcgtct ttaagcagta cttcttcgag acaaagtgcc gggacccaaa ccccgtggac     2520

agcggctgca gaggcattga ctccaagcac tggaactcct actgcaccac aacacacacc     2580

ttcgtgaagg ccctgaccat ggacggcaaa caagctgcct ggcggttcat cagaatcgac     2640

accgcctgtg tctgtgtgct gagcagaaag gccgtgcgcc gggcctagtc ctgttaatca     2700

acctctggat tacaaaattt gtgaaagatt gactgatatt cttaactatg ttgctccttt     2760

tacgctgtgt ggatatgctg ctttaatgcc tctgtatcat gctattgctt cccgtacggc     2820

tttcgttttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg agttgtggcc     2880

cgttgtccgt caacgtggcg tggtgtgctc tgtgtttgct gacgcaaccc ccactggctg     2940

gggcattgcc accacctgtc aactcctttc tgggactttc gctttccccc tccctatcgc     3000

cacggcagaa ctcatcgccg cctgccttgc ccgctgctgg acaggggcta ggttgctggg     3060

cactgataat tccgtggtgt tgtcggggaa gctgacgtcc gactgtgcct tctagttgcc     3120

agccatctgt tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca     3180

ctgtcctttc ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta     3240

ttctgggggg tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc     3300

atgctgggga tgcggtgggc tctatggagc gctggctaga attacctacc ggcctccacc     3360

ataccttcga tattcgcgcc cactctccca ttaatccgca caagtggatg tgatgcgatt     3420

gcccgctaag atagttaatc attaactaca aggaacccct agtgatggag ttggccactc     3480

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     3540

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcga tatcgaatcg aatgcagtga     3600

tctcccaggt gcgaatcaaa aatactaggt aactagagga tttgcgacgt tctaagcgtt     3660

ggtccatgtg aatcgccatc caggatccca atggcgcgcc gagcttggct cgagcatggt     3720

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg     3780

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt     3840

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg     3900

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg     3960

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa     4020

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc     4080

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     4140

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     4200

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     4260

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     4320

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     4380

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     4440

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     4500

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     4560

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     4620

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc     4680

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg     4740

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga     4800

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg     4860

agtaaacttg gtctgacagt tagaaaaact catcgagcat caaatgaaac tgcaatttat     4920

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa     4980

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc     5040

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga     5100

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc     5160

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac     5220

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac     5280

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     5340

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttccca gggatcgcag     5400

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     5460

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     5520

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     5580

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     5640

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcatactct     5700

tcctttttca atattattga agcatttatc agggttattg tctcatgagc ggatacatat     5760

ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc     5820

cacctgacgt ctaagaaacc attattatca tgacattaac ctataaaaat aggcgtatca     5880

cgaggccctt tcgtc                                                      5895


