                               SEQUENCE LISTING

<110> TRUSTEES OF TUFTS COLLEGE
      VICERO, INC.
 
<120> VHH POLYPEPTIDES THAT BIND TO INTERLEUKIN 6 (IL-6), COMPOSITIONS
      AND METHODS OF USE THEREOF

<130> 167774.012601/PCT

<140>
<141>

<150> 63/184,441
<151> 2021-05-05

<160> 105   

<170> PatentIn version 3.5

<210> 1
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Gln Leu Gln Leu Ala Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Leu Lys Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ala Lys Ser Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Thr Trp Asp Leu Lys Phe Gly Tyr Asn Ile Ser Ala Cys 
            100                 105                 110         


Val Gly Ser Tyr Glu Tyr Asp Tyr Trp Asp Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210> 2
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
cagttgcagc tggcggagac tggtggaggg ttggtccagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttggat tattatgccg taggctggtt ccgccaggcc      120

ccagggaagg agcgtgaggg gatctcatgt attagtagta gtgatcttaa aacatactat      180

gcagactccg tgaagggccg attcaccatc tccagagact acgccaagag cacggtgtct      240

ctgcaaatga acagcctgaa acctgaggac acaggcgttt attactgtgc ggcgggcaca      300

tgggatctta agttcggcta taatattagt gcctgcgtgg gatcttatga gtatgactac      360

tgggaccagg ggacccaggt caccgtctcc tca                                   393


<210> 3
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Pro Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Trp Ser Arg Gly Thr Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Asp Gly Trp Lys Val Val Ser Thr Ala Ser Pro Ala Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 4
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
caggtgcagc tcgtggagtc aggaggagga ttggtgcagg ctggggactc tctgacactc       60

tcctgtgcag cctctggacg ccccttcagt agttttgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attacatgga gtcgtggtac cacacactat      180

gccgactccg tgaagggccg gttcaccatc tccggggaca acgccaagaa cacggtgttt      240

ctgcaaatga acagcctaaa acctgaggat acggccgttt attactgtgc agcagcggat      300

ggatggaagg tagttagtac tgctagcccc gcgtatgact actggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210> 5
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ala Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Cys Ile Ser Ser Ser Asp Leu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Thr Trp Asp Leu Lys Phe Gly Tyr Ser Arg Ser Asn Cys 
            100                 105                 110         


Val Arg Ser Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210> 6
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
cagttgcagc tggtggagtc cggtggaggc ttggtgcagc ctggggggtc tctgggactc       60

tcctgtgcag cctctggatt cactttggct tattatggca taggctggtt ccgccaggcc      120

ccagggaagg agcgtgaggg ggtcgcatgt attagtagta gtgatcttag cacatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagga cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acagccgttt attactgtgc agcgggcaca      300

tgggatctta aattcggcta tagtagaagt aactgcgtgc gatcttatga gtatgactac      360

tggggccagg ggacccaggt caccgtctcc tca                                   393


<210> 7
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Gln Val Gln Leu Ala Glu Thr Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Arg 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Ser Trp Thr Gly Ser Pro Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Thr Ser Glu His Val Met Leu Val Val Thr Thr Arg Gly Gly Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 8
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
caggtgcagc tggcggagac cggcggagga tcggtgcagg ctgggggctc tctgacactc       60

tcctgtgcag cctctggacg caccttcagt agcagagcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagtt attagctgga ctggtagccc atactataca      180

gactccgtga agggccgatt caccatctcc agagacgacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtttatt actgcgcagc gacgtcagaa      300

catgtaatgc tggtagttac tacgcgtggc gggtatgact actggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210> 9
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Leu Ser Ser Ser Asp Arg Ser Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Asp Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Thr Trp Asp Leu Lys Trp Gly Tyr Asn Ile Ser Ala Cys 
            100                 105                 110         


Val Gly Ser Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210> 10
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
cagttgcagc tggtggagac aggaggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttggat tattatgcca taggctggtt ccgccaggct      120

ccagggaagg agcgtgaggg ggtctcatgt ttgagtagta gtgatcgtag cacatactat      180

gtagactccg tgaagggccg attcaccatc tccagagacg atgacaagaa cacggcgtat      240

ctgcagatga acagcctgaa acctgaggac acagccactt attactgtgc agcgggcaca      300

tgggatctta aatggggcta taacattagt gcctgcgtgg gatcttatga gtatgactac      360

tggggccagg ggacgcaggt caccgtctcc tca                                   393


<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ser Ser Ser Asp Arg Ser Thr Tyr 
1               5               


<210> 13
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Thr Trp Asp Leu Lys Trp Gly Tyr Asn Ile Ser Ala Cys Val Gly 
1               5                   10                  15      


Ser Tyr Glu Tyr Asp Tyr 
            20          


<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Ser Ser Ser Asp Arg Ser Ala Tyr 
1               5               


<210> 15
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Thr Trp Asp Leu Lys Trp Gly Tyr Asn Ile Ser Ala Cys Val Arg 
1               5                   10                  15      


Ser Tyr Glu Tyr Asp Tyr 
            20          


<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Ser Ser Ser Asp Leu Lys Thr Tyr 
1               5               


<210> 17
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gly Thr Trp Asp Leu Lys Phe Gly Tyr Asn Ile Ser Ala Cys Val Gly 
1               5                   10                  15      


Ser Tyr Glu Tyr Asp Tyr 
            20          


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gly Phe Ala Leu Asp Tyr Tyr Ala 
1               5               


<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Phe Thr Leu Asp Tyr Tyr Gly 
1               5               


<210> 20
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gly Thr Trp Asp Leu Lys Phe Gly Tyr Asn Ile Thr Thr Cys Val Arg 
1               5                   10                  15      


Ser Ser Glu Tyr Asp Tyr 
            20          


<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Phe Thr Ser Asp Tyr Tyr Gly 
1               5               


<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Ser Ser Ser Asp Trp Ser Thr Tyr 
1               5               


<210> 23
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gly Thr Trp Asp Leu Lys Phe Gly Tyr Asn Arg Ser Asn Cys Val Arg 
1               5                   10                  15      


Ser Ala Glu Tyr Asp Tyr 
            20          


<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Gly Phe Thr Leu Ala Tyr Tyr Gly 
1               5               


<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Ser Ser Ser Asp Leu Ser Thr Tyr 
1               5               


<210> 26
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Gly Thr Trp Asp Leu Lys Phe Gly Tyr Ser Arg Ser Asn Cys Val Arg 
1               5                   10                  15      


Ser Tyr Glu Tyr Asp Tyr 
            20          


<210> 27
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> T or absent

<220>
<221> MOD_RES
<222> (2)..(2)
<223> S, T, or G

<220>
<221> MOD_RES
<222> (13)..(13)
<223> L or Q

<220>
<221> MOD_RES
<222> (14)..(14)
<223> R or G

<400> 27
Xaa Xaa Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Xaa Xaa Leu Ser 
1               5                   10                  15      


Cys Ala Ala Ser 
            20  


<210> 28
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> I or V

<220>
<221> MOD_RES
<222> (15)..(15)
<223> V or I

<220>
<221> MOD_RES
<222> (16)..(16)
<223> S or A

<220>
<221> MOD_RES
<222> (18)..(18)
<223> L, I, or M

<400> 28
Xaa Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Xaa Xaa 
1               5                   10                  15      


Cys Xaa 
        


<210> 29
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V, I, T, or A

<220>
<221> MOD_RES
<222> (14)..(14)
<223> D, G, N, Y, or S

<220>
<221> MOD_RES
<222> (15)..(15)
<223> D or A

<220>
<221> MOD_RES
<222> (16)..(16)
<223> K or N

<220>
<221> MOD_RES
<222> (17)..(17)
<223> N, S, or D

<220>
<221> MOD_RES
<222> (18)..(18)
<223> T or A

<220>
<221> MOD_RES
<222> (19)..(19)
<223> A or V

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Y or S

<220>
<221> MOD_RES
<222> (32)..(32)
<223> A or G

<220>
<221> MOD_RES
<222> (33)..(33)
<223> T or V

<400> 29
Xaa Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Xaa 
            20                  25                  30          


Xaa Tyr Tyr Cys Ala Ala 
        35              


<210> 30
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> W or R

<220>
<221> MOD_RES
<222> (2)..(2)
<223> G or D

<400> 30
Xaa Xaa Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Gly Arg Pro Phe Ser Ser Phe Ala 
1               5               


<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Thr Trp Ser Arg Gly Thr Thr His 
1               5               


<210> 33
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Ala Ala Ala Asp Gly Trp Lys Val Val Ser Thr Ala Ser Pro Ala Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210> 34
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Gly Arg Thr Phe Ser Ser Arg Ala 
1               5               


<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Ser Trp Thr Gly Ser Pro Tyr 
1               5           


<210> 36
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Ala Ala Thr Ser Glu His Val Met Leu Val Val Thr Thr Arg Gly Gly 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210> 37
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> L or V

<220>
<221> MOD_RES
<222> (5)..(5)
<223> A or V

<220>
<221> MOD_RES
<222> (7)..(7)
<223> T or S

<220>
<221> MOD_RES
<222> (11)..(11)
<223> L or S

<220>
<221> MOD_RES
<222> (14)..(14)
<223> P or A

<220>
<221> MOD_RES
<222> (16)..(16)
<223> G or D

<220>
<221> MOD_RES
<222> (19)..(19)
<223> R, T, or G

<400> 37
Gln Xaa Gln Leu Xaa Glu Xaa Gly Gly Gly Xaa Val Gln Xaa Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 38
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V, M, or I

<220>
<221> MOD_RES
<222> (14)..(14)
<223> F or G

<220>
<221> MOD_RES
<222> (15)..(15)
<223> I or V

<220>
<221> MOD_RES
<222> (16)..(16)
<223> S or A

<220>
<221> MOD_RES
<222> (17)..(17)
<223> C, A, or V

<220>
<221> MOD_RES
<222> (18)..(18)
<223> I or L

<400> 38
Xaa Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210> 39
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> A, T, or V

<220>
<221> MOD_RES
<222> (13)..(13)
<223> R or G

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Y, N, or D

<220>
<221> MOD_RES
<222> (16)..(16)
<223> A or D

<220>
<221> MOD_RES
<222> (18)..(18)
<223> S, N, or D

<220>
<221> MOD_RES
<222> (20)..(20)
<223> V or A

<220>
<221> MOD_RES
<222> (21)..(21)
<223> S, F, or Y

<220>
<221> MOD_RES
<222> (33)..(33)
<223> G or A

<220>
<221> MOD_RES
<222> (34)..(34)
<223> V or T

<400> 39
Tyr Xaa Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Xaa Asp Xaa Xaa 
1               5                   10                  15      


Lys Xaa Thr Xaa Xaa Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Xaa Xaa Tyr Tyr Cys Ala Ala 
        35                  


<210> 40
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> D or G

<400> 40
Trp Xaa Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Asp Glu Leu Gly Pro Arg Leu Met Gly Lys 
1               5                   10  


<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210> 43
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gly Gly Gly Gly Ser 
1               5   


<210> 44
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 45
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Glu Pro Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gln Gly Val Gln Ser Gln Val Gln Leu 
            20                  25                  30          


Val Glu 
        


<210> 46
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Glu Pro Lys Thr Pro Lys Pro Gln 
1               5               


<210> 47
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Q or V

<220>
<221> MOD_RES
<222> (11)..(11)
<223> L or S

<220>
<221> MOD_RES
<222> (14)..(14)
<223> A or P

<400> 47
Gln Val Gln Leu Xaa Glu Ser Gly Gly Gly Xaa Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 48
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> F, Y, or V

<220>
<221> MOD_RES
<222> (9)..(9)
<223> E, C, or G

<220>
<221> MOD_RES
<222> (10)..(10)
<223> R or L

<220>
<221> MOD_RES
<222> (12)..(12)
<223> F, G, L, or W

<220>
<221> MOD_RES
<222> (14)..(14)
<223> A, S, or T

<400> 48
Trp Xaa Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Xaa Val Xaa 
1               5                   10                  


<210> 49
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> A, Q, T, or V

<220>
<221> MOD_RES
<222> (3)..(3)
<223> D or E

<220>
<221> MOD_RES
<222> (5)..(5)
<223> V or A

<220>
<221> MOD_RES
<222> (10)..(10)
<223> T or A

<220>
<221> MOD_RES
<222> (11)..(11)
<223> I or V

<220>
<221> MOD_RES
<222> (13)..(13)
<223> R or Q

<220>
<221> MOD_RES
<222> (15)..(15)
<223> N or K

<220>
<221> MOD_RES
<222> (17)..(17)
<223> K or A

<220>
<221> MOD_RES
<222> (20)..(20)
<223> V, L, or M

<220>
<221> MOD_RES
<222> (25)..(25)
<223> N or D

<220>
<221> MOD_RES
<222> (26)..(26)
<223> S or N

<220>
<221> MOD_RES
<222> (28)..(28)
<223> K or R

<220>
<221> MOD_RES
<222> (30)..(30)
<223> E or D

<220>
<221> MOD_RES
<222> (33)..(33)
<223> A or G

<220>
<221> MOD_RES
<222> (34)..(34)
<223> V, I, T, or M

<400> 49
Tyr Xaa Xaa Ser Xaa Lys Gly Arg Phe Xaa Xaa Ser Xaa Asp Xaa Ala 
1               5                   10                  15      


Xaa Asn Thr Xaa Tyr Leu Gln Met Xaa Xaa Leu Xaa Pro Xaa Asp Thr 
            20                  25                  30          


Xaa Xaa Tyr Tyr Cys 
        35          


<210> 50
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 52
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      His tag


<220>
<221> SITE
<222> (1)..(10)
<223> This sequence may encompass 5-10 residues

<400> 52
His His His His His His His His His His 
1               5                   10  


<210> 53
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 53
His His His His His His 
1               5       


<210> 54
<211> 212
<212> PRT
<213> Homo sapiens

<400> 54
Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210> 55
<211> 1127
<212> DNA
<213> Homo sapiens

<400> 55
attctgccct cgagcccacc gggaacgaaa gagaagctct atctcccctc caggagccca       60

gctatgaact ccttctccac aagcgccttc ggtccagttg ccttctccct ggggctgctc      120

ctggtgttgc ctgctgcctt ccctgcccca gtacccccag gagaagattc caaagatgta      180

gccgccccac acagacagcc actcacctct tcagaacgaa ttgacaaaca aattcggtac      240

atcctcgacg gcatctcagc cctgagaaag gagacatgta acaagagtaa catgtgtgaa      300

agcagcaaag aggcactggc agaaaacaac ctgaaccttc caaagatggc tgaaaaagat      360

ggatgcttcc aatctggatt caatgaggag acttgcctgg tgaaaatcat cactggtctt      420

ttggagtttg aggtatacct agagtacctc cagaacagat ttgagagtag tgaggaacaa      480

gccagagctg tgcagatgag tacaaaagtc ctgatccagt tcctgcagaa aaaggcaaag      540

aatctagatg caataaccac ccctgaccca accacaaatg ccagcctgct gacgaagctg      600

caggcacaga accagtggct gcaggacatg acaactcatc tcattctgcg cagctttaag      660

gagttcctgc agtccagcct gagggctctt cggcaaatgt agcatgggca cctcagattg      720

ttgttgttaa tgggcattcc ttcttctggt cagaaacctg tccactgggc acagaactta      780

tgttgttctc tatggagaac taaaagtatg agcgttagga cactatttta attattttta      840

atttattaat atttaaatat gtgaagctga gttaatttat gtaagtcata tttatatttt      900

taagaagtac cacttgaaac attttatgta ttagttttga aataataatg gaaagtggct      960

atgcagtttg aatatccttt gtttcagagc cagatcattt cttggaaagt gtaggcttac     1020

ctcaaataaa tggctaactt atacatattt ttaaagaaat atttatattg tatttatata     1080

atgtataaat ggtttttata ccaataaatg gcattttaaa aaattca                   1127


<210> 56
<211> 211
<212> PRT
<213> Mus musculus

<400> 56
Met Lys Phe Leu Ser Ala Arg Asp Phe His Pro Val Ala Phe Leu Gly 
1               5                   10                  15      


Leu Met Leu Val Thr Thr Thr Ala Phe Pro Thr Ser Gln Val Arg Arg 
            20                  25                  30          


Gly Asp Phe Thr Glu Asp Thr Thr Pro Asn Arg Pro Val Tyr Thr Thr 
        35                  40                  45              


Ser Gln Val Gly Gly Leu Ile Thr His Val Leu Trp Glu Ile Val Glu 
    50                  55                  60                  


Met Arg Lys Glu Leu Cys Asn Gly Asn Ser Asp Cys Met Asn Asn Asp 
65                  70                  75                  80  


Asp Ala Leu Ala Glu Asn Asn Leu Lys Leu Pro Glu Ile Gln Arg Asn 
                85                  90                  95      


Asp Gly Cys Tyr Gln Thr Gly Tyr Asn Gln Glu Ile Cys Leu Leu Lys 
            100                 105                 110         


Ile Ser Ser Gly Leu Leu Glu Tyr His Ser Tyr Leu Glu Tyr Met Lys 
        115                 120                 125             


Asn Asn Leu Lys Asp Asn Lys Lys Asp Lys Ala Arg Val Leu Gln Arg 
    130                 135                 140                 


Asp Thr Glu Thr Leu Ile His Ile Phe Asn Gln Glu Val Lys Asp Leu 
145                 150                 155                 160 


His Lys Ile Val Leu Pro Thr Pro Ile Ser Asn Ala Leu Leu Thr Asp 
                165                 170                 175     


Lys Leu Glu Ser Gln Lys Glu Trp Leu Arg Thr Lys Thr Ile Gln Phe 
            180                 185                 190         


Ile Leu Lys Ser Leu Glu Glu Phe Leu Lys Val Thr Leu Arg Ser Thr 
        195                 200                 205             


Arg Gln Thr 
    210     


<210> 57
<211> 1141
<212> DNA
<213> Mus musculus

<400> 57
aaatatgaga ctggggatgt ctgtagctca ttctgctctg gagcccacca agaacgatag       60

tcaattccag aaaccgctat gaagttcctc tctgcaagag acttccatcc agttgccttc      120

ttgggactga tgctggtgac aaccacggcc ttccctactt cacaagtccg gagaggagac      180

ttcacagagg ataccactcc caacagacct gtctatacca cttcacaagt cggaggctta      240

attacacatg ttctctggga aatcgtggaa atgagaaaag agttgtgcaa tggcaattct      300

gattgtatga acaacgatga tgcacttgca gaaaacaatc tgaaacttcc agagatacaa      360

agaaatgatg gatgctacca aactggatat aatcaggaaa tttgcctatt gaaaatttcc      420

tctggtcttc tggagtacca tagctacctg gagtacatga agaacaactt aaaagataac      480

aagaaagaca aagccagagt ccttcagaga gatacagaaa ctctaattca tatcttcaac      540

caagaggtaa aagatttaca taaaatagtc cttcctaccc caatttccaa tgctctccta      600

acagataagc tggagtcaca gaaggagtgg ctaaggacca agaccatcca attcatcttg      660

aaatcacttg aagaatttct aaaagtcact ttgagatcta ctcggcaaac ctagtgcgtt      720

atgcctaagc atatcagttt gtggacattc ctcactgtgg tcagaaaata tatcctgttg      780

tcaggtatct gacttatgtt gttctctacg aagaactgac aatatgaatg ttgggacact      840

attttaatta tttttaattt attgataatt taaataagta aactttaagt taatttatga      900

ttgatattta ttatttttat gaagtgtcac ttgaaatgtt atatgttata gttttgaaat      960

gataacctaa aaatctattt gatataaata ttctgttacc tagccagatg gtttcttgga     1020

atgtataagt ttacctcaat gaattgctaa tttaaatatg tttttaaaga aatctttgtg     1080

atgtattttt ataatgttta gactgtcttc aaacaaataa attatattat atttaaaaac     1140

c                                                                     1141


<210> 58
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser 
            


<210> 59
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser 
            


<210> 60
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Thr Gly Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
1               5                   10                  15      


Cys Ala Ala Ser 
            20  


<210> 61
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  15      


Cys Leu 
        


<210> 62
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile Ser 
1               5                   10                  15      


Cys Ile 
        


<210> 63
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  15      


Cys Met 
        


<210> 64
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  15      


Cys Ile 
        


<210> 65
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
1               5                   10                  15      


Cys Ile 
        


<210> 66
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Asp 
1               5                   10                  15      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Thr Tyr Tyr Cys Ala Ala 
        35                  


<210> 67
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Ala Ile Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210> 68
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Asn Asn Ala Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Gly Val Tyr Tyr Cys Ala Ala 
        35                  


<210> 69
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ala 
1               5                   10                  15      


Lys Ser Thr Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Gly Val Tyr Tyr Cys Ala Ala 
        35                  


<210> 70
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 70
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Ser Thr Val Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Gly Val Tyr Tyr Cys Ala Ala 
        35                  


<210> 71
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Gly Val Tyr Tyr Cys Ala Ala 
        35                  


<210> 72
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210> 73
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asp Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210> 74
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Trp Asp Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210> 75
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210> 76
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Gln Leu Gln Leu Ala Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 77
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 77
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 78
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 78
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 79
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 79
Gln Val Gln Leu Ala Glu Thr Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 80
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 80
Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210> 81
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  15      


Ala Ile 
        


<210> 82
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 82
Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  15      


Val Ile 
        


<210> 83
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Val Phe Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210> 84
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210> 85
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> SITE
<222> (1)..(150)
<223> This sequence may encompass 1-30 "Gly Gly Gly Gly Ser"
      repeating units

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 85
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 


<210> 86
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
1               5                   10              


<210> 87
<211> 277
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ala Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Cys Ile Ser Ser Ser Asp Leu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Thr Trp Asp Leu Lys Phe Gly Tyr Ser Arg Ser Asn Cys 
            100                 105                 110         


Val Arg Ser Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ala 
                165                 170                 175     


Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
            180                 185                 190         


Gly Val Ala Cys Ile Ser Ser Ser Asp Leu Ser Thr Tyr Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr 
    210                 215                 220                 


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ala Gly Thr Trp Asp Leu Lys Phe Gly Tyr Ser Arg Ser 
                245                 250                 255     


Asn Cys Val Arg Ser Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser 
        275         


<210> 88
<211> 131
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ala Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Cys Ile Ser Ser Ser Asp Leu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Thr Trp Asp Leu Lys Phe Gly Tyr Ser Arg Ser Asn Cys 
            100                 105                 110         


Val Arg Ser Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210> 89
<211> 296
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
        35                  40                  45              


Ala Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ala Cys Ile Ser Ser Ser Asp Leu Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Thr Trp Asp Leu Lys Phe Gly Tyr Ser Arg 
        115                 120                 125             


Ser Asn Cys Val Arg Ser Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                165                 170                 175     


Val Gln Pro Gly Gly Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe 
            180                 185                 190         


Thr Leu Ala Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Arg Glu Gly Val Ala Cys Ile Ser Ser Ser Asp Leu Ser Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
225                 230                 235                 240 


Lys Asp Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp Leu Lys Phe Gly Tyr 
            260                 265                 270         


Ser Arg Ser Asn Cys Val Arg Ser Tyr Glu Tyr Asp Tyr Trp Gly Gln 
        275                 280                 285             


Gly Thr Gln Val Thr Val Ser Ser 
    290                 295     


<210> 90
<211> 315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
        35                  40                  45              


Ala Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ala Cys Ile Ser Ser Ser Asp Leu Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Gly Thr Trp Asp Leu Lys Phe Gly Tyr Ser Arg 
        115                 120                 125             


Ser Asn Cys Val Arg Ser Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
                165                 170                 175     


Val Gln Pro Gly Gly Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe 
            180                 185                 190         


Thr Leu Ala Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Arg Glu Gly Val Ala Cys Ile Ser Ser Ser Asp Leu Ser Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
225                 230                 235                 240 


Lys Asp Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp Leu Lys Phe Gly Tyr 
            260                 265                 270         


Ser Arg Ser Asn Cys Val Arg Ser Tyr Glu Tyr Asp Tyr Trp Gly Gln 
        275                 280                 285             


Gly Thr Gln Val Thr Val Ser Ser His His His His His His Asp Ile 
    290                 295                 300                 


Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
305                 310                 315 


<210> 91
<211> 611
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
        35                  40                  45              


Ala Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Gly Val Ala Cys Ile Ser Ser Ser Asp Gln Val Gln Leu Val Glu 
65                  70                  75                  80  


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Gly Leu Ser Cys 
                85                  90                  95      


Ala Ala Ser Gly Phe Thr Leu Ala Tyr Tyr Gly Ile Gly Trp Phe Arg 
            100                 105                 110         


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Cys Ile Ser Ser Ser 
        115                 120                 125             


Asp Leu Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    130                 135                 140                 


Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu Gln Met Asn Ser Leu 
145                 150                 155                 160 


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                165                 170                 175     


Leu Lys Phe Gly Tyr Ser Arg Ser Asn Cys Val Arg Ser Tyr Glu Tyr 
            180                 185                 190         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Leu Ser Thr Tyr Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Asp Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp Leu Lys Phe Gly Tyr Ser 
                245                 250                 255     


Arg Ser Asn Cys Val Arg Ser Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Gln Pro Gly Gly Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Thr Leu Ala Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Glu Arg Glu Gly Val Ala Cys Ile Ser Ser Ser Asp Leu Ser Ser 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        355                 360                 365             


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    370                 375                 380                 


Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ala Tyr Tyr 
385                 390                 395                 400 


Gly Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
                405                 410                 415     


Ala Cys Ile Ser Ser Ser Asp Leu Ser Thr Tyr Tyr Ala Asp Ser Val 
            420                 425                 430         


Lys Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
    450                 455                 460                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp Leu 
465                 470                 475                 480 


Lys Phe Gly Tyr Ser Arg Ser Asn Cys Val Arg Ser Tyr Glu Tyr Asp 
                485                 490                 495     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Arg Phe Thr Ile 
            500                 505                 510         


Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu Gln Met Asn Ser Leu 
        515                 520                 525             


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
    530                 535                 540                 


Leu Lys Phe Gly Tyr Ser Arg Ser Asn Cys Val Arg Ser Tyr Glu Tyr 
545                 550                 555                 560 


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His 
                565                 570                 575     


His His His His His His His His His Asp Ile Cys Leu Pro Arg Trp 
            580                 585                 590         


Gly Cys Leu Trp Glu Asp Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu 
        595                 600                 605             


Trp Glu Asp 
    610     


<210> 92
<211> 1938
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 92
gaattccccc gccgccaccg ccgccaccat gggctggtcc tgcatcattc tgtttctggt       60

ggccacagcc accggcgtgc actctcaagt tcagctatgg gctggtcctg catcattctg      120

tttctggtgg ccacagccac cggcgtgcac tctcaagttc agctggttga gtctggcggc      180

ggactggttc aacctggtgg atctctggga ctgagctgtg ccgcctctgg ctttacactg      240

gcctactatg gttgagtctg gcggcggact ggttcaacct ggtggatctc tgggactgag      300

ctgtgccgcc tctggcttta cactggccta ctatggcatc ggctggttca gacaggcccc      360

tggcaaagag agagagggcg tcgcctgtat cagcagcagc gatctgagca cctactacgg      420

gcatcggctg gttcagacag gcccctggca aagagagaga gggcgtcgcc tgtatcagca      480

gcagcgatct gagcacctac tacgccgaca gcgtgaaggg caccgacagc gtgaagggca      540

gattcaccat cagccgggac aacgccaagg acaccgtgta cctgcagatg aacagcctga      600

agcctgagat tcaccatcag ccgggacaac gccaaggaca ccgtgtacct gcagatgaac      660

agcctgaagc ctgaggacac cgccgtgtac tattgtgccg ccggaacctg ggatctgaag      720

ttcggctaca gccggtccaa ttgcgtgcgg agctacgagg gacaccgccg tgtactattg      780

tgccgccgga acctgggatc tgaagttcgg ctacagccgg tccaattgcg tgcggagcta      840

cgagtacgat tactggggcc agggcaccca agtgacagtc tcttctggcg gaggcggatc      900

aggtggcgga ggaagcggag gcggcggaat acgattactg gggccagggc acccaagtga      960

cagtctcttc tggcggaggc ggatcaggtg gcggaggaag cggaggcggc ggaagtcaag     1020

tgcaactggt ggagtcaagt gcaactggtg gaatcaggcg gaggccttgt tcagcctggc     1080

ggaagccttg gactgtcttg tgctgccagc ggattcacat caggcggagg ccttgttcag     1140

cctggcggaa gccttggact gtcttgtgct gccagcggat tcaccctggc ctattacgga     1200

attggatggt ttcggcaggc cccagggaaa gaacgagaag gggttgcctg catcagctcc     1260

agcgacctgc ctggcctatt acggaattgg atggtttcgg caggccccag ggaaagaacg     1320

agaaggggtt gcctgcatca gctccagcga cctgtctacc tattatgccg actccgtgaa     1380

aggccggttt accatcagca gagataatgc caaagatacg gtctatctcc agatgaactt     1440

ctacctatta tgccgactcc gtgaaaggcc ggtttaccat cagcagagat aatgccaaag     1500

atacggtcta tctccagatg aactctctca agcccgagga tacactctca agcccgagga     1560

tacagccgtc tattactgcg ccgctggcac atgggacctg aaatttggct actcccgcag     1620

caactgcgtg ccgtctatta ctgcgccgct ggcacatggg acctgaaatt tggctactcc     1680

cgcagcaact gcgtgcggtc ttacgagtat gactattggg gacaagggac acaagtgacc     1740

gtgtccagcc accaccacca tcaccatgcg gtcttacgag tatgactatt ggggacaagg     1800

gacacaagtg accgtgtcca gccaccacca ccatcaccat gatatctgcc tgatatctgc     1860

ctgcctagat ggggctgcct gtgggaagat gcctagatgg ggctgcctgt gggaagattg     1920

atgattaagc ttaagctt                                                   1938


<210> 93
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 93
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Ile Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Leu Ser Ser Ser 
        35                  40                  45              


Asp Arg Ser Thr Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Asp Asp Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Trp Gly Tyr Asn Ile Ser Ala Cys Val Gly Ser Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 94
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Ile Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Leu Ser Ser Ser 
        35                  40                  45              


Asp Arg Ser Thr Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Asp Asp Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Trp Gly Tyr Asn Ile Ser Ala Cys Val Gly Ser Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 95
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 95
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Ile Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Leu Ser Ser Ser 
        35                  40                  45              


Asp Arg Ser Ala Tyr Ala Ile Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Gly Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Trp Gly Tyr Asn Ile Ser Ala Cys Val Arg Ser Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 96
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Val Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile Ser Cys Ile Ser Ser Ser 
        35                  40                  45              


Asp Leu Lys Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Asn Ala Asn Asn Ala Val Ser Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Phe Gly Tyr Asn Ile Ser Ala Cys Val Gly Ser Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 97
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 97
Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Val Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile Ser Cys Ile Ser Ser Ser 
        35                  40                  45              


Asp Leu Lys Thr Tyr Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Asn Ala Asn Asn Ala Val Ser Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Phe Gly Tyr Asn Ile Ser Ala Cys Val Gly Ser Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 98
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Val Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile Ser Cys Ile Ser Ser Ser 
        35                  40                  45              


Asp Leu Lys Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Tyr Ala Lys Ser Thr Val Ser Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Phe Gly Tyr Asn Ile Ser Ala Cys Val Gly Ser Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Asp Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 99
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 99
Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Val Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile Ser Cys Ile Ser Ser Ser 
        35                  40                  45              


Asp Leu Lys Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Tyr Ala Lys Ser Thr Val Ser Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Phe Gly Tyr Asn Ile Ser Ala Cys Val Gly Ser Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 100
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 100
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Ala Val Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile Ser Cys Ile Ser Ser Ser 
        35                  40                  45              


Asp Leu Lys Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Asn Ala Lys Ser Thr Val Ser Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Phe Gly Tyr Asn Ile Ser Ala Cys Val Gly Ser Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 101
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 101
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr Ala Val Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile Ser Cys Ile Ser Ser Ser 
        35                  40                  45              


Asp Leu Lys Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Asn Ala Lys Ser Thr Val Ser Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Phe Gly Tyr Asn Ile Ser Ala Cys Val Gly Ser Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 102
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 102
Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Gly Ile Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Met Ser Ser Ser 
        35                  40                  45              


Asp Leu Lys Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Phe Gly Tyr Asn Ile Thr Thr Cys Val Arg Ser Ser Glu Tyr 
            100                 105                 110         


Asp Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 103
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 103
Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Ser Asp Tyr Tyr Gly Ile Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Met Ser Ser Ser 
        35                  40                  45              


Asp Leu Lys Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Phe Gly Tyr Asn Ile Thr Thr Cys Val Arg Ser Ser Glu Tyr 
            100                 105                 110         


Asp Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 104
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 104
Thr Gly Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
1               5                   10                  15      


Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Gly Ile Gly Trp Phe 
            20                  25                  30          


Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Ser Ser 
        35                  40                  45              


Ser Asp Trp Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    50                  55                  60                  


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
65                  70                  75                  80  


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Thr Trp 
                85                  90                  95      


Asp Leu Lys Phe Gly Tyr Asn Arg Ser Asn Cys Val Arg Ser Ala Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210> 105
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 105
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Ala Tyr Tyr Gly Ile Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Cys Ile Ser Ser Ser 
        35                  40                  45              


Asp Leu Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Thr Trp Asp 
                85                  90                  95      


Leu Lys Phe Gly Tyr Ser Arg Ser Asn Cys Val Arg Ser Tyr Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


