                               SEQUENCE LISTING

<110> UNIVERSITY OF WASHINGTON
 
<120> ELECTROPHYSIOLOGICAL MODIFICATION TO SUPPRESS ARRHYTHMIAS

<130> 034186-190040WOPT

<140> PCT/US2022/027382
<141> 2022-05-03

<150> 63/292,046
<151> 2021-12-21

<150> 63/211,843
<151> 2021-06-17

<150> 63/183,528
<151> 2021-05-03

<160> 87    

<170> PatentIn version 3.5

<210> 1
<211> 1203
<212> PRT
<213> Homo sapiens

<400> 1
Met Asp Lys Leu Pro Pro Ser Met Arg Lys Arg Leu Tyr Ser Leu Pro 
1               5                   10                  15      


Gln Gln Val Gly Ala Lys Ala Trp Ile Met Asp Glu Glu Glu Asp Ala 
            20                  25                  30          


Glu Glu Glu Gly Ala Gly Gly Arg Gln Asp Pro Ser Arg Arg Ser Ile 
        35                  40                  45              


Arg Leu Arg Pro Leu Pro Ser Pro Ser Pro Ser Ala Ala Ala Gly Gly 
    50                  55                  60                  


Thr Glu Ser Arg Ser Ser Ala Leu Gly Ala Ala Asp Ser Glu Gly Pro 
65                  70                  75                  80  


Ala Arg Gly Ala Gly Lys Ser Ser Thr Asn Gly Asp Cys Arg Arg Phe 
                85                  90                  95      


Arg Gly Ser Leu Ala Ser Leu Gly Ser Arg Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Thr Gly Ser Gly Ser Ser His Gly His Leu His Asp Ser Ala Glu Glu 
        115                 120                 125             


Arg Arg Leu Ile Ala Glu Gly Asp Ala Ser Pro Gly Glu Asp Arg Thr 
    130                 135                 140                 


Pro Pro Gly Leu Ala Ala Glu Pro Glu Arg Pro Gly Ala Ser Ala Gln 
145                 150                 155                 160 


Pro Ala Ala Ser Pro Pro Pro Pro Gln Gln Pro Pro Gln Pro Ala Ser 
                165                 170                 175     


Ala Ser Cys Glu Gln Pro Ser Val Asp Thr Ala Ile Lys Val Glu Gly 
            180                 185                 190         


Gly Ala Ala Ala Gly Asp Gln Ile Leu Pro Glu Ala Glu Val Arg Leu 
        195                 200                 205             


Gly Gln Ala Gly Phe Met Gln Arg Gln Phe Gly Ala Met Leu Gln Pro 
    210                 215                 220                 


Gly Val Asn Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys Ala Val 
225                 230                 235                 240 


Glu Arg Glu Gln Glu Arg Val Lys Ser Ala Gly Phe Trp Ile Ile His 
                245                 250                 255     


Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Leu Thr Met Leu Leu Leu 
            260                 265                 270         


Met Val Gly Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe Phe Lys 
        275                 280                 285             


Asp Glu Asn Thr Thr Pro Trp Ile Val Phe Asn Val Val Ser Asp Thr 
    290                 295                 300                 


Phe Phe Leu Ile Asp Leu Val Leu Asn Phe Arg Thr Gly Ile Val Val 
305                 310                 315                 320 


Glu Asp Asn Thr Glu Ile Ile Leu Asp Pro Gln Arg Ile Lys Met Lys 
                325                 330                 335     


Tyr Leu Lys Ser Trp Phe Met Val Asp Phe Ile Ser Ser Ile Pro Val 
            340                 345                 350         


Asp Tyr Ile Phe Leu Ile Val Glu Thr Arg Ile Asp Ser Glu Val Tyr 
        355                 360                 365             


Lys Thr Ala Arg Ala Leu Arg Ile Val Arg Phe Thr Lys Ile Leu Ser 
    370                 375                 380                 


Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile His Gln 
385                 390                 395                 400 


Trp Glu Glu Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala Val Val 
                405                 410                 415     


Arg Ile Val Asn Leu Ile Gly Met Met Leu Leu Leu Cys His Trp Asp 
            420                 425                 430         


Gly Cys Leu Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro Asp Asp 
        435                 440                 445             


Cys Trp Val Ser Ile Asn Asn Met Val Asn Asn Ser Trp Gly Lys Gln 
    450                 455                 460                 


Tyr Ser Tyr Ala Leu Phe Lys Ala Met Ser His Met Leu Cys Ile Gly 
465                 470                 475                 480 


Tyr Gly Arg Gln Ala Pro Val Gly Met Ser Asp Val Trp Leu Thr Met 
                485                 490                 495     


Leu Ser Met Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile Gly His 
            500                 505                 510         


Ala Thr Ala Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln Tyr Gln 
        515                 520                 525             


Glu Lys Tyr Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys Leu Pro 
    530                 535                 540                 


Pro Asp Thr Arg Gln Arg Ile His Asp Tyr Tyr Glu His Arg Tyr Gln 
545                 550                 555                 560 


Gly Lys Met Phe Asp Glu Glu Ser Ile Leu Gly Glu Leu Ser Glu Pro 
                565                 570                 575     


Leu Arg Glu Glu Ile Ile Asn Phe Asn Cys Arg Lys Leu Val Ala Ser 
            580                 585                 590         


Met Pro Leu Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ser Met Leu 
        595                 600                 605             


Thr Lys Leu Arg Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile Ile Arg 
    610                 615                 620                 


Glu Gly Thr Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Lys Gly Asn Lys Glu Thr Lys Leu Ala Asp Gly Ser 
                645                 650                 655     


Tyr Phe Gly Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr Ala Ser 
            660                 665                 670         


Val Arg Ala Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val Asp Asn 
        675                 680                 685             


Phe Asn Glu Val Leu Glu Glu Tyr Pro Met Met Arg Arg Ala Phe Glu 
    690                 695                 700                 


Thr Val Ala Leu Asp Arg Leu Asp Arg Ile Gly Lys Lys Asn Ser Ile 
705                 710                 715                 720 


Leu Leu His Lys Val Gln His Asp Leu Asn Ser Gly Val Phe Asn Tyr 
                725                 730                 735     


Gln Glu Asn Glu Ile Ile Gln Gln Ile Val Gln His Asp Arg Glu Met 
            740                 745                 750         


Ala His Cys Ala His Arg Val Gln Ala Ala Ala Ser Ala Thr Pro Thr 
        755                 760                 765             


Pro Thr Pro Val Ile Trp Thr Pro Leu Ile Gln Ala Pro Leu Gln Ala 
    770                 775                 780                 


Ala Ala Ala Thr Thr Ser Val Ala Ile Ala Leu Thr His His Pro Arg 
785                 790                 795                 800 


Leu Pro Ala Ala Ile Phe Arg Pro Pro Pro Gly Ser Gly Leu Gly Asn 
                805                 810                 815     


Leu Gly Ala Gly Gln Thr Pro Arg His Leu Lys Arg Leu Gln Ser Leu 
            820                 825                 830         


Ile Pro Ser Ala Leu Gly Ser Ala Ser Pro Ala Ser Ser Pro Ser Gln 
        835                 840                 845             


Val Asp Thr Pro Ser Ser Ser Ser Phe His Ile Gln Gln Leu Ala Gly 
    850                 855                 860                 


Phe Ser Ala Pro Ala Gly Leu Ser Pro Leu Leu Pro Ser Ser Ser Ser 
865                 870                 875                 880 


Ser Pro Pro Pro Gly Ala Cys Gly Ser Pro Ser Ala Pro Thr Pro Ser 
                885                 890                 895     


Ala Gly Val Ala Ala Thr Thr Ile Ala Gly Phe Gly His Phe His Lys 
            900                 905                 910         


Ala Leu Gly Gly Ser Leu Ser Ser Ser Asp Ser Pro Leu Leu Thr Pro 
        915                 920                 925             


Leu Gln Pro Gly Ala Arg Ser Pro Gln Ala Ala Gln Pro Ser Pro Ala 
    930                 935                 940                 


Pro Pro Gly Ala Arg Gly Gly Leu Gly Leu Pro Glu His Phe Leu Pro 
945                 950                 955                 960 


Pro Pro Pro Ser Ser Arg Ser Pro Ser Ser Ser Pro Gly Gln Leu Gly 
                965                 970                 975     


Gln Pro Pro Gly Glu Leu Ser Leu Gly Leu Ala Thr Gly Pro Leu Ser 
            980                 985                 990         


Thr Pro Glu Thr Pro Pro Arg Gln  Pro Glu Pro Pro Ser  Leu Val Ala 
        995                 1000                 1005             


Gly Ala  Ser Gly Gly Ala Ser  Pro Val Gly Phe Thr  Pro Arg Gly 
    1010                 1015                 1020             


Gly Leu  Ser Pro Pro Gly His  Ser Pro Gly Pro Pro  Arg Thr Phe 
    1025                 1030                 1035             


Pro Ser  Ala Pro Pro Arg Ala  Ser Gly Ser His Gly  Ser Leu Leu 
    1040                 1045                 1050             


Leu Pro  Pro Ala Ser Ser Pro  Pro Pro Pro Gln Val  Pro Gln Arg 
    1055                 1060                 1065             


Arg Gly  Thr Pro Pro Leu Thr  Pro Gly Arg Leu Thr  Gln Asp Leu 
    1070                 1075                 1080             


Lys Leu  Ile Ser Ala Ser Gln  Pro Ala Leu Pro Gln  Asp Gly Ala 
    1085                 1090                 1095             


Gln Thr  Leu Arg Arg Ala Ser  Pro His Ser Ser Gly  Glu Ser Met 
    1100                 1105                 1110             


Ala Ala  Phe Pro Leu Phe Pro  Arg Ala Gly Gly Gly  Ser Gly Gly 
    1115                 1120                 1125             


Ser Gly  Ser Ser Gly Gly Leu  Gly Pro Pro Gly Arg  Pro Tyr Gly 
    1130                 1135                 1140             


Ala Ile  Pro Gly Gln His Val  Thr Leu Pro Arg Lys  Thr Ser Ser 
    1145                 1150                 1155             


Gly Ser  Leu Pro Pro Pro Leu  Ser Leu Phe Gly Ala  Arg Ala Thr 
    1160                 1165                 1170             


Ser Ser  Gly Gly Pro Pro Leu  Thr Ala Gly Pro Gln  Arg Glu Pro 
    1175                 1180                 1185             


Gly Ala  Arg Pro Glu Pro Val  Arg Ser Lys Leu Pro  Ser Asn Leu 
    1190                 1195                 1200             


<210> 2
<211> 2353
<212> PRT
<213> Homo sapiens

<400> 2
Met Thr Glu Gly Ala Arg Ala Ala Asp Glu Val Arg Val Pro Leu Gly 
1               5                   10                  15      


Ala Pro Pro Pro Gly Pro Ala Ala Leu Val Gly Ala Ser Pro Glu Ser 
            20                  25                  30          


Pro Gly Ala Pro Gly Arg Glu Ala Glu Arg Gly Ser Glu Leu Gly Val 
        35                  40                  45              


Ser Pro Ser Glu Ser Pro Ala Ala Glu Arg Gly Ala Glu Leu Gly Ala 
    50                  55                  60                  


Asp Glu Glu Gln Arg Val Pro Tyr Pro Ala Leu Ala Ala Thr Val Phe 
65                  70                  75                  80  


Phe Cys Leu Gly Gln Thr Thr Arg Pro Arg Ser Trp Cys Leu Arg Leu 
                85                  90                  95      


Val Cys Asn Pro Trp Phe Glu His Val Ser Met Leu Val Ile Met Leu 
            100                 105                 110         


Asn Cys Val Thr Leu Gly Met Phe Arg Pro Cys Glu Asp Val Glu Cys 
        115                 120                 125             


Gly Ser Glu Arg Cys Asn Ile Leu Glu Ala Phe Asp Ala Phe Ile Phe 
    130                 135                 140                 


Ala Phe Phe Ala Val Glu Met Val Ile Lys Met Val Ala Leu Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe 
                165                 170                 175     


Phe Ile Val Val Ala Gly Met Met Glu Tyr Ser Leu Asp Gly His Asn 
            180                 185                 190         


Val Ser Leu Ser Ala Ile Arg Thr Val Arg Val Leu Arg Pro Leu Arg 
        195                 200                 205             


Ala Ile Asn Arg Val Pro Ser Met Arg Ile Leu Val Thr Leu Leu Leu 
    210                 215                 220                 


Asp Thr Leu Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val 
225                 230                 235                 240 


Phe Phe Ile Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu 
                245                 250                 255     


Arg Asn Arg Cys Phe Leu Asp Ser Ala Phe Val Arg Asn Asn Asn Leu 
            260                 265                 270         


Thr Phe Leu Arg Pro Tyr Tyr Gln Thr Glu Glu Gly Glu Glu Asn Pro 
        275                 280                 285             


Phe Ile Cys Ser Ser Arg Arg Asp Asn Gly Met Gln Lys Cys Ser His 
    290                 295                 300                 


Ile Pro Gly Arg Arg Glu Leu Arg Met Pro Cys Thr Leu Gly Trp Glu 
305                 310                 315                 320 


Ala Tyr Thr Gln Pro Gln Ala Glu Gly Val Gly Ala Ala Arg Asn Ala 
                325                 330                 335     


Cys Ile Asn Trp Asn Gln Tyr Tyr Asn Val Cys Arg Ser Gly Asp Ser 
            340                 345                 350         


Asn Pro His Asn Gly Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp 
        355                 360                 365             


Ile Ala Ile Phe Gln Val Ile Thr Leu Glu Gly Trp Val Asp Ile Met 
    370                 375                 380                 


Tyr Tyr Val Met Asp Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile 
385                 390                 395                 400 


Leu Leu Ile Ile Val Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val 
                405                 410                 415     


Val Ile Ala Thr Gln Phe Ser Glu Thr Lys Gln Arg Glu Ser Gln Leu 
            420                 425                 430         


Met Arg Glu Gln Arg Ala Arg His Leu Ser Asn Asp Ser Thr Leu Ala 
        435                 440                 445             


Ser Phe Ser Glu Pro Gly Ser Cys Tyr Glu Glu Leu Leu Lys Tyr Val 
    450                 455                 460                 


Gly His Ile Phe Arg Lys Val Lys Arg Arg Ser Leu Arg Leu Tyr Ala 
465                 470                 475                 480 


Arg Trp Gln Ser Arg Trp Arg Lys Lys Val Asp Pro Ser Ala Val Gln 
                485                 490                 495     


Gly Gln Gly Pro Gly His Arg Gln Arg Arg Ala Gly Arg His Thr Ala 
            500                 505                 510         


Ser Val His His Leu Val Tyr His His His His His His His His His 
        515                 520                 525             


Tyr His Phe Ser His Gly Ser Pro Arg Arg Pro Gly Pro Glu Pro Gly 
    530                 535                 540                 


Ala Cys Asp Thr Arg Leu Val Arg Ala Gly Ala Pro Pro Ser Pro Pro 
545                 550                 555                 560 


Ser Pro Gly Arg Gly Pro Pro Asp Ala Glu Ser Val His Ser Ile Tyr 
                565                 570                 575     


His Ala Asp Cys His Ile Glu Gly Pro Gln Glu Arg Ala Arg Val Ala 
            580                 585                 590         


His Ala Ala Ala Thr Ala Ala Ala Ser Leu Arg Leu Ala Thr Gly Leu 
        595                 600                 605             


Gly Thr Met Asn Tyr Pro Thr Ile Leu Pro Ser Gly Val Gly Ser Gly 
    610                 615                 620                 


Lys Gly Ser Thr Ser Pro Gly Pro Lys Gly Lys Trp Ala Gly Gly Pro 
625                 630                 635                 640 


Pro Gly Thr Gly Gly His Gly Pro Leu Ser Leu Asn Ser Pro Asp Pro 
                645                 650                 655     


Tyr Glu Lys Ile Pro His Val Val Gly Glu His Gly Leu Gly Gln Ala 
            660                 665                 670         


Pro Gly His Leu Ser Gly Leu Ser Val Pro Cys Pro Leu Pro Ser Pro 
        675                 680                 685             


Pro Ala Gly Thr Leu Thr Cys Glu Leu Lys Ser Cys Pro Tyr Cys Thr 
    690                 695                 700                 


Arg Ala Leu Glu Asp Pro Glu Gly Glu Leu Ser Gly Ser Glu Ser Gly 
705                 710                 715                 720 


Asp Ser Asp Gly Arg Gly Val Tyr Glu Phe Thr Gln Asp Val Arg His 
                725                 730                 735     


Gly Asp Arg Trp Asp Pro Thr Arg Pro Pro Arg Ala Thr Asp Thr Pro 
            740                 745                 750         


Gly Pro Gly Pro Gly Ser Pro Gln Arg Arg Ala Gln Gln Arg Ala Ala 
        755                 760                 765             


Pro Gly Glu Pro Gly Trp Met Gly Arg Leu Trp Val Thr Phe Ser Gly 
    770                 775                 780                 


Lys Leu Arg Arg Ile Val Asp Ser Lys Tyr Phe Ser Arg Gly Ile Met 
785                 790                 795                 800 


Met Ala Ile Leu Val Asn Thr Leu Ser Met Gly Val Glu Tyr His Glu 
                805                 810                 815     


Gln Pro Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe 
            820                 825                 830         


Thr Ser Met Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Ala Cys Gly 
        835                 840                 845             


Pro Leu Gly Tyr Ile Arg Asn Pro Tyr Asn Ile Phe Asp Gly Ile Ile 
    850                 855                 860                 


Val Val Ile Ser Val Trp Glu Ile Val Gly Gln Ala Asp Gly Gly Leu 
865                 870                 875                 880 


Ser Val Leu Arg Thr Phe Arg Leu Leu Arg Val Leu Lys Leu Val Arg 
                885                 890                 895     


Phe Leu Pro Ala Leu Arg Arg Gln Leu Val Val Leu Val Lys Thr Met 
            900                 905                 910         


Asp Asn Val Ala Thr Phe Cys Thr Leu Leu Met Leu Phe Ile Phe Ile 
        915                 920                 925             


Phe Ser Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ser Leu Lys 
    930                 935                 940                 


Thr Asp Thr Gly Asp Thr Val Pro Asp Arg Lys Asn Phe Asp Ser Leu 
945                 950                 955                 960 


Leu Trp Ala Ile Val Thr Val Phe Gln Ile Leu Thr Gln Glu Asp Trp 
                965                 970                 975     


Asn Val Val Leu Tyr Asn Gly Met Ala Ser Thr Ser Ser Trp Ala Ala 
            980                 985                 990         


Leu Tyr Phe Val Ala Leu Met Thr  Phe Gly Asn Tyr Val  Leu Phe Asn 
        995                 1000                 1005             


Leu Leu  Val Ala Ile Leu Val  Glu Gly Phe Gln Ala  Glu Gly Asp 
    1010                 1015                 1020             


Ala Asn  Arg Ser Asp Thr Asp  Glu Asp Lys Thr Ser  Val His Phe 
    1025                 1030                 1035             


Glu Glu  Asp Phe His Lys Leu  Arg Glu Leu Gln Thr  Thr Glu Leu 
    1040                 1045                 1050             


Lys Met  Cys Ser Leu Ala Val  Thr Pro Asn Gly His  Leu Glu Gly 
    1055                 1060                 1065             


Arg Gly  Ser Leu Ser Pro Pro  Leu Ile Met Cys Thr  Ala Ala Thr 
    1070                 1075                 1080             


Pro Met  Pro Thr Pro Lys Ser  Ser Pro Phe Leu Asp  Ala Ala Pro 
    1085                 1090                 1095             


Ser Leu  Pro Asp Ser Arg Arg  Gly Ser Ser Ser Ser  Gly Asp Pro 
    1100                 1105                 1110             


Pro Leu  Gly Asp Gln Lys Pro  Pro Ala Ser Leu Arg  Ser Ser Pro 
    1115                 1120                 1125             


Cys Ala  Pro Trp Gly Pro Ser  Gly Ala Trp Ser Ser  Arg Arg Ser 
    1130                 1135                 1140             


Ser Trp  Ser Ser Leu Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Gly 
    1145                 1150                 1155             


Gln Cys  Gly Glu Arg Glu Ser  Leu Leu Ser Gly Glu  Gly Lys Gly 
    1160                 1165                 1170             


Ser Thr  Asp Asp Glu Ala Glu  Asp Gly Arg Ala Ala  Pro Gly Pro 
    1175                 1180                 1185             


Arg Ala  Thr Pro Leu Arg Arg  Ala Glu Ser Leu Asp  Pro Arg Pro 
    1190                 1195                 1200             


Leu Arg  Pro Ala Ala Leu Pro  Pro Thr Lys Cys Arg  Asp Arg Asp 
    1205                 1210                 1215             


Gly Gln  Val Val Ala Leu Pro  Ser Asp Phe Phe Leu  Arg Ile Asp 
    1220                 1225                 1230             


Ser His  Arg Glu Asp Ala Ala  Glu Leu Asp Asp Asp  Ser Glu Asp 
    1235                 1240                 1245             


Ser Cys  Cys Leu Arg Leu His  Lys Val Leu Glu Pro  Tyr Lys Pro 
    1250                 1255                 1260             


Gln Trp  Cys Arg Ser Arg Glu  Ala Trp Ala Leu Tyr  Leu Phe Ser 
    1265                 1270                 1275             


Pro Gln  Asn Arg Phe Arg Val  Ser Cys Gln Lys Val  Ile Thr His 
    1280                 1285                 1290             


Lys Met  Phe Asp His Val Val  Leu Val Phe Ile Phe  Leu Asn Cys 
    1295                 1300                 1305             


Val Thr  Ile Ala Leu Glu Arg  Pro Asp Ile Asp Pro  Gly Ser Thr 
    1310                 1315                 1320             


Glu Arg  Val Phe Leu Ser Val  Ser Asn Tyr Ile Phe  Thr Ala Ile 
    1325                 1330                 1335             


Phe Val  Ala Glu Met Met Val  Lys Val Val Ala Leu  Gly Leu Leu 
    1340                 1345                 1350             


Ser Gly  Glu His Ala Tyr Leu  Gln Ser Ser Trp Asn  Leu Leu Asp 
    1355                 1360                 1365             


Gly Leu  Leu Val Leu Val Ser  Leu Val Asp Ile Val  Val Ala Met 
    1370                 1375                 1380             


Ala Ser  Ala Gly Gly Ala Lys  Ile Leu Gly Val Leu  Arg Val Leu 
    1385                 1390                 1395             


Arg Leu  Leu Arg Thr Leu Arg  Pro Leu Arg Val Ile  Ser Arg Ala 
    1400                 1405                 1410             


Pro Gly  Leu Lys Leu Val Val  Glu Thr Leu Ile Ser  Ser Leu Arg 
    1415                 1420                 1425             


Pro Ile  Gly Asn Ile Val Leu  Ile Cys Cys Ala Phe  Phe Ile Ile 
    1430                 1435                 1440             


Phe Gly  Ile Leu Gly Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Tyr 
    1445                 1450                 1455             


Cys Glu  Gly Pro Asp Thr Arg  Asn Ile Ser Thr Lys  Ala Gln Cys 
    1460                 1465                 1470             


Arg Ala  Ala His Tyr Arg Trp  Val Arg Arg Lys Tyr  Asn Phe Asp 
    1475                 1480                 1485             


Asn Leu  Gly Gln Ala Leu Met  Ser Leu Phe Val Leu  Ser Ser Lys 
    1490                 1495                 1500             


Asp Gly  Trp Val Asn Ile Met  Tyr Asp Gly Leu Asp  Ala Val Gly 
    1505                 1510                 1515             


Val Asp  Gln Gln Pro Val Gln  Asn His Asn Pro Trp  Met Leu Leu 
    1520                 1525                 1530             


Tyr Phe  Ile Ser Phe Leu Leu  Ile Val Ser Phe Phe  Val Leu Asn 
    1535                 1540                 1545             


Met Phe  Val Gly Val Val Val  Glu Asn Phe His Lys  Cys Arg Gln 
    1550                 1555                 1560             


His Gln  Glu Ala Glu Glu Ala  Arg Arg Arg Glu Glu  Lys Arg Leu 
    1565                 1570                 1575             


Arg Arg  Leu Glu Arg Arg Arg  Arg Ser Thr Phe Pro  Ser Pro Glu 
    1580                 1585                 1590             


Ala Gln  Arg Arg Pro Tyr Tyr  Ala Asp Tyr Ser Pro  Thr Arg Arg 
    1595                 1600                 1605             


Ser Ile  His Ser Leu Cys Thr  Ser His Tyr Leu Asp  Leu Phe Ile 
    1610                 1615                 1620             


Thr Phe  Ile Ile Cys Val Asn  Val Ile Thr Met Ser  Met Glu His 
    1625                 1630                 1635             


Tyr Asn  Gln Pro Lys Ser Leu  Asp Glu Ala Leu Lys  Tyr Cys Asn 
    1640                 1645                 1650             


Tyr Val  Phe Thr Ile Val Phe  Val Phe Glu Ala Ala  Leu Lys Leu 
    1655                 1660                 1665             


Val Ala  Phe Gly Phe Arg Arg  Phe Phe Lys Asp Arg  Trp Asn Gln 
    1670                 1675                 1680             


Leu Asp  Leu Ala Ile Val Leu  Leu Ser Leu Met Gly  Ile Thr Leu 
    1685                 1690                 1695             


Glu Glu  Ile Glu Met Ser Ala  Ala Leu Pro Ile Asn  Pro Thr Ile 
    1700                 1705                 1710             


Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala Arg Val  Leu Lys Leu 
    1715                 1720                 1725             


Leu Lys  Met Ala Thr Gly Met  Arg Ala Leu Leu Asp  Thr Val Val 
    1730                 1735                 1740             


Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly Leu Leu  Phe Met Leu 
    1745                 1750                 1755             


Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val Glu Leu  Phe Gly Arg 
    1760                 1765                 1770             


Leu Glu  Cys Ser Glu Asp Asn  Pro Cys Glu Gly Leu  Ser Arg His 
    1775                 1780                 1785             


Ala Thr  Phe Ser Asn Phe Gly  Met Ala Phe Leu Thr  Leu Phe Arg 
    1790                 1795                 1800             


Val Ser  Thr Gly Asp Asn Trp  Asn Gly Ile Met Lys  Asp Thr Leu 
    1805                 1810                 1815             


Arg Glu  Cys Ser Arg Glu Asp  Lys His Cys Leu Ser  Tyr Leu Pro 
    1820                 1825                 1830             


Ala Leu  Ser Pro Val Tyr Phe  Val Thr Phe Val Leu  Val Ala Gln 
    1835                 1840                 1845             


Phe Val  Leu Val Asn Val Val  Val Ala Val Leu Met  Lys His Leu 
    1850                 1855                 1860             


Glu Glu  Ser Asn Lys Glu Ala  Arg Glu Asp Ala Glu  Leu Asp Ala 
    1865                 1870                 1875             


Glu Ile  Glu Leu Glu Met Ala  Gln Gly Pro Gly Ser  Ala Arg Arg 
    1880                 1885                 1890             


Val Asp  Ala Asp Arg Pro Pro  Leu Pro Gln Glu Ser  Pro Gly Ala 
    1895                 1900                 1905             


Arg Asp  Ala Pro Asn Leu Val  Ala Arg Lys Val Ser  Val Ser Arg 
    1910                 1915                 1920             


Met Leu  Ser Leu Pro Asn Asp  Ser Tyr Met Phe Arg  Pro Val Val 
    1925                 1930                 1935             


Pro Ala  Ser Ala Pro His Pro  Arg Pro Leu Gln Glu  Val Glu Met 
    1940                 1945                 1950             


Glu Thr  Tyr Gly Ala Gly Thr  Pro Leu Gly Ser Val  Ala Ser Val 
    1955                 1960                 1965             


His Ser  Pro Pro Ala Glu Ser  Cys Ala Ser Leu Gln  Ile Pro Leu 
    1970                 1975                 1980             


Ala Val  Ser Ser Pro Ala Arg  Ser Gly Glu Pro Leu  His Ala Leu 
    1985                 1990                 1995             


Ser Pro  Arg Gly Thr Ala Arg  Ser Pro Ser Leu Ser  Arg Leu Leu 
    2000                 2005                 2010             


Cys Arg  Gln Glu Ala Val His  Thr Asp Ser Leu Glu  Gly Lys Ile 
    2015                 2020                 2025             


Asp Ser  Pro Arg Asp Thr Leu  Asp Pro Ala Glu Pro  Gly Glu Lys 
    2030                 2035                 2040             


Thr Pro  Val Arg Pro Val Thr  Gln Gly Gly Ser Leu  Gln Ser Pro 
    2045                 2050                 2055             


Pro Arg  Ser Pro Arg Pro Ala  Ser Val Arg Thr Arg  Lys His Thr 
    2060                 2065                 2070             


Phe Gly  Gln Arg Cys Val Ser  Ser Arg Pro Ala Ala  Pro Gly Gly 
    2075                 2080                 2085             


Glu Glu  Ala Glu Ala Ser Asp  Pro Ala Asp Glu Glu  Val Ser His 
    2090                 2095                 2100             


Ile Thr  Ser Ser Ala Cys Pro  Trp Gln Pro Thr Ala  Glu Pro His 
    2105                 2110                 2115             


Gly Pro  Glu Ala Ser Pro Val  Ala Gly Gly Glu Arg  Asp Leu Arg 
    2120                 2125                 2130             


Arg Leu  Tyr Ser Val Asp Ala  Gln Gly Phe Leu Asp  Lys Pro Gly 
    2135                 2140                 2145             


Arg Ala  Asp Glu Gln Trp Arg  Pro Ser Ala Glu Leu  Gly Ser Gly 
    2150                 2155                 2160             


Glu Pro  Gly Glu Ala Lys Ala  Trp Gly Pro Glu Ala  Glu Pro Ala 
    2165                 2170                 2175             


Leu Gly  Ala Arg Arg Lys Lys  Lys Met Ser Pro Pro  Cys Ile Ser 
    2180                 2185                 2190             


Val Glu  Pro Pro Ala Glu Asp  Glu Gly Ser Ala Arg  Pro Ser Ala 
    2195                 2200                 2205             


Ala Glu  Gly Gly Ser Thr Thr  Leu Arg Arg Arg Thr  Pro Ser Cys 
    2210                 2215                 2220             


Glu Ala  Thr Pro His Arg Asp  Ser Leu Glu Pro Thr  Glu Gly Ser 
    2225                 2230                 2235             


Gly Ala  Gly Gly Asp Pro Ala  Ala Lys Gly Glu Arg  Trp Gly Gln 
    2240                 2245                 2250             


Ala Ser  Cys Arg Ala Glu His  Leu Thr Val Pro Ser  Phe Ala Phe 
    2255                 2260                 2265             


Glu Pro  Leu Asp Leu Gly Val  Pro Ser Gly Asp Pro  Phe Leu Asp 
    2270                 2275                 2280             


Gly Ser  His Ser Val Thr Pro  Glu Ser Arg Ala Ser  Ser Ser Gly 
    2285                 2290                 2295             


Ala Ile  Val Pro Leu Glu Pro  Pro Glu Ser Glu Pro  Pro Met Pro 
    2300                 2305                 2310             


Val Gly  Asp Pro Pro Glu Lys  Arg Arg Gly Leu Tyr  Leu Thr Val 
    2315                 2320                 2325             


Pro Gln  Cys Pro Leu Glu Lys  Pro Gly Ser Pro Ser  Ala Thr Pro 
    2330                 2335                 2340             


Ala Pro  Gly Gly Gly Ala Asp  Asp Pro Val 
    2345                 2350             


<210> 3
<211> 973
<212> PRT
<213> Homo sapiens

<400> 3
Met Tyr Asn Met Arg Arg Leu Ser Leu Ser Pro Thr Phe Ser Met Gly 
1               5                   10                  15      


Phe His Leu Leu Val Thr Val Ser Leu Leu Phe Ser His Val Asp His 
            20                  25                  30          


Val Ile Ala Glu Thr Glu Met Glu Gly Glu Gly Asn Glu Thr Gly Glu 
        35                  40                  45              


Cys Thr Gly Ser Tyr Tyr Cys Lys Lys Gly Val Ile Leu Pro Ile Trp 
    50                  55                  60                  


Glu Pro Gln Asp Pro Ser Phe Gly Asp Lys Ile Ala Arg Ala Thr Val 
65                  70                  75                  80  


Tyr Phe Val Ala Met Val Tyr Met Phe Leu Gly Val Ser Ile Ile Ala 
                85                  90                  95      


Asp Arg Phe Met Ser Ser Ile Glu Val Ile Thr Ser Gln Glu Lys Glu 
            100                 105                 110         


Ile Thr Ile Lys Lys Pro Asn Gly Glu Thr Thr Lys Thr Thr Val Arg 
        115                 120                 125             


Ile Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser 
    130                 135                 140                 


Ser Ala Pro Glu Ile Leu Leu Ser Val Ile Glu Val Cys Gly His Asn 
145                 150                 155                 160 


Phe Thr Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala 
                165                 170                 175     


Phe Asn Met Phe Ile Ile Ile Ala Leu Cys Val Tyr Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Val Thr Ala 
        195                 200                 205             


Ala Trp Ser Ile Phe Ala Tyr Thr Trp Leu Tyr Ile Ile Leu Ser Val 
    210                 215                 220                 


Ile Ser Pro Gly Val Val Glu Val Trp Glu Gly Leu Leu Thr Phe Phe 
225                 230                 235                 240 


Phe Phe Pro Ile Cys Val Val Phe Ala Trp Val Ala Asp Arg Arg Leu 
                245                 250                 255     


Leu Phe Tyr Lys Tyr Val Tyr Lys Arg Tyr Arg Ala Gly Lys Gln Arg 
            260                 265                 270         


Gly Met Ile Ile Glu His Glu Gly Asp Arg Pro Ser Ser Lys Thr Glu 
        275                 280                 285             


Ile Glu Met Asp Gly Lys Val Val Asn Ser His Val Glu Asn Phe Leu 
    290                 295                 300                 


Asp Gly Ala Leu Val Leu Glu Val Asp Glu Arg Asp Gln Asp Asp Glu 
305                 310                 315                 320 


Glu Ala Arg Arg Glu Met Ala Arg Ile Leu Lys Glu Leu Lys Gln Lys 
                325                 330                 335     


His Pro Asp Lys Glu Ile Glu Gln Leu Ile Glu Leu Ala Asn Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Gln Gln Lys Ser Arg Ala Phe Tyr Arg Ile Gln Ala 
        355                 360                 365             


Thr Arg Leu Met Thr Gly Ala Gly Asn Ile Leu Lys Arg His Ala Ala 
    370                 375                 380                 


Asp Gln Ala Arg Lys Ala Val Ser Met His Glu Val Asn Thr Glu Val 
385                 390                 395                 400 


Thr Glu Asn Asp Pro Val Ser Lys Ile Phe Phe Glu Gln Gly Thr Tyr 
                405                 410                 415     


Gln Cys Leu Glu Asn Cys Gly Thr Val Ala Leu Thr Ile Ile Arg Arg 
            420                 425                 430         


Gly Gly Asp Leu Thr Asn Thr Val Phe Val Asp Phe Arg Thr Glu Asp 
        435                 440                 445             


Gly Thr Ala Asn Ala Gly Ser Asp Tyr Glu Phe Thr Glu Gly Thr Val 
    450                 455                 460                 


Val Phe Lys Pro Gly Asp Thr Gln Lys Glu Ile Arg Val Gly Ile Ile 
465                 470                 475                 480 


Asp Asp Asp Ile Phe Glu Glu Asp Glu Asn Phe Leu Val His Leu Ser 
                485                 490                 495     


Asn Val Lys Val Ser Ser Glu Ala Ser Glu Asp Gly Ile Leu Glu Ala 
            500                 505                 510         


Asn His Val Ser Thr Leu Ala Cys Leu Gly Ser Pro Ser Thr Ala Thr 
        515                 520                 525             


Val Thr Ile Phe Asp Asp Asp His Ala Gly Ile Phe Thr Phe Glu Glu 
    530                 535                 540                 


Pro Val Thr His Val Ser Glu Ser Ile Gly Ile Met Glu Val Lys Val 
545                 550                 555                 560 


Leu Arg Thr Ser Gly Ala Arg Gly Asn Val Ile Val Pro Tyr Lys Thr 
                565                 570                 575     


Ile Glu Gly Thr Ala Arg Gly Gly Gly Glu Asp Phe Glu Asp Thr Cys 
            580                 585                 590         


Gly Glu Leu Glu Phe Gln Asn Asp Glu Ile Val Lys Thr Ile Ser Val 
        595                 600                 605             


Lys Val Ile Asp Asp Glu Glu Tyr Glu Lys Asn Lys Thr Phe Phe Leu 
    610                 615                 620                 


Glu Ile Gly Glu Pro Arg Leu Val Glu Met Ser Glu Lys Lys Ala Leu 
625                 630                 635                 640 


Leu Leu Asn Glu Leu Gly Gly Phe Thr Ile Thr Gly Lys Tyr Leu Phe 
                645                 650                 655     


Gly Gln Pro Val Phe Arg Lys Val His Ala Arg Glu His Pro Ile Leu 
            660                 665                 670         


Ser Thr Val Ile Thr Ile Ala Asp Glu Tyr Asp Asp Lys Gln Pro Leu 
        675                 680                 685             


Thr Ser Lys Glu Glu Glu Glu Arg Arg Ile Ala Glu Met Gly Arg Pro 
    690                 695                 700                 


Ile Leu Gly Glu His Thr Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr 
705                 710                 715                 720 


Glu Phe Lys Ser Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala 
                725                 730                 735     


Leu Val Val Gly Thr Asn Ser Trp Arg Glu Gln Phe Ile Glu Ala Ile 
            740                 745                 750         


Thr Val Ser Ala Gly Glu Asp Asp Asp Asp Asp Glu Cys Gly Glu Glu 
        755                 760                 765             


Lys Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe 
    770                 775                 780                 


Trp Lys Val Leu Phe Ala Phe Val Pro Pro Thr Glu Tyr Trp Asn Gly 
785                 790                 795                 800 


Trp Ala Cys Phe Ile Val Ser Ile Leu Met Ile Gly Leu Leu Thr Ala 
                805                 810                 815     


Phe Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys 
            820                 825                 830         


Asp Ser Val Thr Ala Val Val Phe Val Ala Leu Gly Thr Ser Val Pro 
        835                 840                 845             


Asp Thr Phe Ala Ser Lys Val Ala Ala Thr Gln Asp Gln Tyr Ala Asp 
    850                 855                 860                 


Ala Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu 
865                 870                 875                 880 


Gly Ile Gly Val Ala Trp Ser Ile Ala Ala Ile Tyr His Ala Ala Asn 
                885                 890                 895     


Gly Glu Gln Phe Lys Val Ser Pro Gly Thr Leu Ala Phe Ser Val Thr 
            900                 905                 910         


Leu Phe Thr Ile Phe Ala Phe Ile Asn Val Gly Val Leu Leu Tyr Arg 
        915                 920                 925             


Arg Arg Pro Glu Ile Gly Gly Glu Leu Gly Gly Pro Arg Thr Ala Lys 
    930                 935                 940                 


Leu Leu Thr Ser Cys Leu Phe Val Leu Leu Trp Leu Leu Tyr Ile Phe 
945                 950                 955                 960 


Phe Ser Ser Leu Glu Ala Tyr Cys His Ile Lys Gly Phe 
                965                 970             


<210> 4
<211> 427
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Ser Val Arg Thr Asn Arg Tyr Ser Ile Val Ser Ser Glu Glu 
1               5                   10                  15      


Asp Gly Met Lys Leu Ala Thr Met Ala Val Ala Asn Gly Phe Gly Asn 
            20                  25                  30          


Gly Lys Ser Lys Val His Thr Arg Gln Gln Cys Arg Ser Arg Phe Val 
        35                  40                  45              


Lys Lys Asp Gly His Cys Asn Val Gln Phe Ile Asn Val Gly Glu Lys 
    50                  55                  60                  


Gly Gln Arg Tyr Leu Ala Asp Ile Phe Thr Thr Cys Val Asp Ile Arg 
65                  70                  75                  80  


Trp Arg Trp Met Leu Val Ile Phe Cys Leu Ala Phe Val Leu Ser Trp 
                85                  90                  95      


Leu Phe Phe Gly Cys Val Phe Trp Leu Ile Ala Leu Leu His Gly Asp 
            100                 105                 110         


Leu Asp Ala Ser Lys Glu Gly Lys Ala Cys Val Ser Glu Val Asn Ser 
        115                 120                 125             


Phe Thr Ala Ala Phe Leu Phe Ser Ile Glu Thr Gln Thr Thr Ile Gly 
    130                 135                 140                 


Tyr Gly Phe Arg Cys Val Thr Asp Glu Cys Pro Ile Ala Val Phe Met 
145                 150                 155                 160 


Val Val Phe Gln Ser Ile Val Gly Cys Ile Ile Asp Ala Phe Ile Ile 
                165                 170                 175     


Gly Ala Val Met Ala Lys Met Ala Lys Pro Lys Lys Arg Asn Glu Thr 
            180                 185                 190         


Leu Val Phe Ser His Asn Ala Val Ile Ala Met Arg Asp Gly Lys Leu 
        195                 200                 205             


Cys Leu Met Trp Arg Val Gly Asn Leu Arg Lys Ser His Leu Val Glu 
    210                 215                 220                 


Ala His Val Arg Ala Gln Leu Leu Lys Ser Arg Ile Thr Ser Glu Gly 
225                 230                 235                 240 


Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Gly Phe Asp Ser 
                245                 250                 255     


Gly Ile Asp Arg Ile Phe Leu Val Ser Pro Ile Thr Ile Val His Glu 
            260                 265                 270         


Ile Asp Glu Asp Ser Pro Leu Tyr Asp Leu Ser Lys Gln Asp Ile Asp 
        275                 280                 285             


Asn Ala Asp Phe Glu Ile Val Val Ile Leu Glu Gly Met Val Glu Ala 
    290                 295                 300                 


Thr Ala Met Thr Thr Gln Cys Arg Ser Ser Tyr Leu Ala Asn Glu Ile 
305                 310                 315                 320 


Leu Trp Gly His Arg Tyr Glu Pro Val Leu Phe Glu Glu Lys His Tyr 
                325                 330                 335     


Tyr Lys Val Asp Tyr Ser Arg Phe His Lys Thr Tyr Glu Val Pro Asn 
            340                 345                 350         


Thr Pro Leu Cys Ser Ala Arg Asp Leu Ala Glu Lys Lys Tyr Ile Leu 
        355                 360                 365             


Ser Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser 
    370                 375                 380                 


Lys Glu Glu Asp Asp Ser Glu Asn Gly Val Pro Glu Ser Thr Ser Thr 
385                 390                 395                 400 


Asp Thr Pro Pro Asp Ile Asp Leu His Asn Gln Ala Ser Val Pro Leu 
                405                 410                 415     


Glu Pro Arg Pro Leu Arg Arg Glu Ser Glu Ile 
            420                 425         


<210> 5
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      "LAGLIDADG" family peptide motif sequence

<400> 5
Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210> 6
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
caccgtcgtg aagcggacaa tgcgc                                             25


<210> 7
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
aaacgcgcat tgtccgcttc acgac                                             25


<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
caccggattt cttcatcgtc gtgg                                              24


<210> 9
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
aaacccacga cgatgaagaa atcc                                              24


<210> 10
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
caccgcagct tgtccatggc gccag                                             25


<210> 11
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
aaacctggcg ccatggacaa gctgc                                             25


<210> 12
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
caccggcagc ttgtccatgg cgcc                                              24


<210> 13
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
aaacggcgcc atggacaagc tgcc                                              24


<210> 14
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
caccgtgctc ggcgcggtcc tgtac                                             25


<210> 15
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
aaacgtacag gaccgcgccg agcac                                             25


<210> 16
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
caccgcctgc atattgtgcc ccgcc                                             25


<210> 17
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
aaacggcggg gcacaatatg caggc                                             25


<210> 18
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
ggaucauauu acuguaagaa                                                   20


<210> 19
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
cagcaauuac augguccaca                                                   20


<210> 20
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ugaaauccca uugaaaaggu                                                   20


<210> 21
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
gaatgcgtcg agatattggg tcgcggccgc acgaacccgg tcgcctccca                  50


<210> 22
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
tggctgatca ttaattaagc gggtttaaac gggcccatgg cgccaggggc cgg              53


<210> 23
<211> 83
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
aaagagagag caatatttca agaatgcatg cgtcaatttt acgcagacta tctttctagg       60

gttaagacaa gctgccgccg tcc                                               83


<210> 24
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
ggtcccggca tccgataccc aatggcgcgc cggctgaatg acccggagct g                51


<210> 25
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
aaacccgctt aattaatgat cagccatcga ttcgactgtg ccttctagtt gccag            55


<210> 26
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
aattttacgc atgattatct ttaacgtacg tcacaatatg attatctttc tagggttaaa       60

cccatagagc ccaccgc                                                      77


<210> 27
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
gaccttaacc atggtgagca aggg                                              24


<210> 28
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
ggttccatcg atttacttgt acagctcgtc catg                                   34


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
ggcctatttc ccatgattcc t                                                 21


<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
gagaacacca caccctggat t                                                 21


<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
tgccacaatc tgacagccta t                                                 21


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
tttcctgatg agccaacgcc                                                   20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
ccggtcactt actaggcacg                                                   20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
tcatgtacaa catgcggcga                                                   20


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
ctccgtcagg caccacataa                                                   20


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
caccctgccc atgtcacagg                                                   20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
gtgacttcgg tcctccaggg                                                   20


<210> 38
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
cgtcaatttt acgcatgatt atctttaac                                         29


<210> 39
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
gcgacggatt cgcgctattt agaaag                                            26


<210> 40
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
gagcggataa caatttcaca cagg                                              24


<210> 41
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
agggttttcc cagtcacgac gtt                                               23


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
gatcctcagc ctcttacgcc                                                   20


<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
ccccaggagt tgttcaccat                                                   20


<210> 44
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
atggtaatcc agaggtcaga ca                                                22


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
ttcttcgagg cggcagtatc                                                   20


<210> 46
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
ggcatggtga accactcgt                                                    19


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
tgtactgctc cacctgcttg                                                   20


<210> 48
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
ggttcctggt tgacctcatc t                                                 21


<210> 49
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
gtgaaagatc tcctcccact ggt                                               23


<210> 50
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
atgctggtaa tcatgctcaa ctg                                               23


<210> 51
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
aaaaggcgaa aatgaaggcg t                                                 21


<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
cgccatcttc caggtcatca                                                   20


<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
tctgagaact gcgtggcaat                                                   20


<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
ggatggagct gatcctcatg t                                                 21


<210> 55
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
aagatgaagt catcaaagac ctgc                                              24


<210> 56
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
gtgcgaacca accgctaca                                                    19


<210> 57
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
ccagcgaatg tccacacac                                                    19


<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 58
agacctggct tcccactttg                                                   20


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
tggcaaatgt gtctggcact                                                   20


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
gtcactgcct cttggagcat                                                   20


<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 61
cacaccggga agaagaccag                                                   20


<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 62
ccgaaatgga tggaacgtgg                                                   20


<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 63
gaatgggtcc ccacaaccaa                                                   20


<210> 64
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 64
ttcaccaaag atctgctcct cgct                                              24


<210> 65
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 65
ttattactgg tgtggagtgg gtgtgg                                            26


<210> 66
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 66
tgacactggc aaaacaatgc a                                                 21


<210> 67
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 67
ggtccttttc accagcaagc t                                                 21


<210> 68
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      CACNA1H exon 4 sequence

<400> 68
Leu Asp Phe Phe Ile Val Val Ala 
1               5               


<210> 69
<211> 24
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown:
      CACNA1H exon 4 sequence

<400> 69
tggatttctt catcgtcgtg gcgg                                              24


<210> 70
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      HCN4 exon 2 sequence

<400> 70
Leu Arg Ile Val Arg Phe Thr Lys 
1               5               


<210> 71
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      CACNA1H exon 4 CACNA1H KO cl. 2 sequence

<400> 71
Val Met Glu Val Ala Phe Phe Ala 
1               5               


<210> 72
<211> 24
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown:
      HCN4 exon 2 sequence

<400> 72
cctgcgcatt gtccgcttca cgaa                                              24


<210> 73
<211> 24
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown:
      CACNA1H exon 4 CACNA1H KO cl. 2 sequence

<400> 73
actggtagag gtggcgtttt ttcc                                              24


<210> 74
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
tggatttctt catcg                                                        15


<210> 75
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
cctgcgattg tccgcttcac gaa                                               23


<210> 76
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
actggtagag gtggcgtttt tttcc                                             25


<210> 77
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
tggatttctt catcgtcgtt ggcg                                              24


<210> 78
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
ccattgtccg cttcacgaa                                                    19


<210> 79
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
actggtagag gtggcccttt acttcc                                            26


<210> 80
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
tggatttctt catcgtctgg gcg                                               23


<210> 81
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      PIEZO1 exon 1 sequence

<400> 81
Val Leu Gly Ala Val Leu Tyr Trp 
1               5               


<210> 82
<211> 8
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      PIEZO1 exon 3 sequence

<400> 82
Cys Leu His Ile Val Pro Arg Leu 
1               5               


<210> 83
<211> 24
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown:
      PIEZO1 exon 1 sequence

<400> 83
gtgctcggcg cggtcctgta ctgg                                              24


<210> 84
<211> 25
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown:
      PIEZO1 exon 3 sequence

<400> 84
tgcctgcata ctgtgccccg cctgg                                             25


<210> 85
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
gtgctcggcg cggtcctgg                                                    19


<210> 86
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 86
tgcctgcata ctgtgcctgg                                                   20


<210> 87
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
tgcctgcata ctgtgcccgc ctgg                                              24


