<110>    ASTON SCI. INC.

<120>    HER2 vaccine composition

<130>    PCT/KR2022/006321(OP2021-309/PCT)

<150>    US 63/183,874
<151>    2021-05-04

<160>    3

<170>    KoPatentIn 3.0

<210>    1
<211>    1254
<212>    PRT
<213>    Homo sapiens

<400>    1
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
  1               5                  10                  15 

Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
             20                  25                  30 

Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
         35                  40                  45 

Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
     50                  55                  60 

Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
 65                  70                  75                  80 

Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                 85                  90                  95 

Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110 

Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125 

Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140 

Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 

Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175 

Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190 

His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205 

Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220 

Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 

Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255 

His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270 

Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285 

Tyr Thr Phe Gly Ala Ser Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser
    290                 295                 300 

Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu
305                 310                 315                 320 

Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro
                325                 330                 335 

Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val
            340                 345                 350 

Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys
        355                 360                 365 

Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro
    370                 375                 380 

Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu
385                 390                 395                 400 

Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp
                405                 410                 415 

Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly
            420                 425                 430 

Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly
        435                 440                 445 

Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu
    450                 455                 460 

Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val Pro
465                 470                 475                 480 

Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala
                485                 490                 495 

Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln
            500                 505                 510 

Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val
        515                 520                 525 

Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg
    530                 535                 540 

Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu
545                 550                 555                 560 

Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe
                565                 570                 575 

Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro
            580                 585                 590 

Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser
        595                 600                 605 

Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro
    610                 615                 620 

Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly
625                 630                 635                 640 

Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala
                645                 650                 655 

Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile
            660                 665                 670 

Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg
        675                 680                 685 

Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala
    690                 695                 700 

Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg
705                 710                 715                 720 

Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly
                725                 730                 735 

Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys
            740                 745                 750 

Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp
        755                 760                 765 

Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu
    770                 775                 780 

Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met
785                 790                 795                 800 

Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg Leu
                805                 810                 815 

Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly Met
            820                 825                 830 

Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala Arg
        835                 840                 845 

Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly
    850                 855                 860 

Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp Gly
865                 870                 875                 880 

Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg
                885                 890                 895 

Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp
            900                 905                 910 

Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg
        915                 920                 925 

Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro
    930                 935                 940 

Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile
945                 950                 955                 960 

Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe Ser
                965                 970                 975 

Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp
            980                 985                 990 

Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu Leu
        995                1000                1005 

Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu Val
   1010                1015                1020 

Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly Gly
1025               1030                1035                1040 

Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly Gly
               1045                1050                1055 

Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg Ser
           1060                1065                1070 

Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly Asp
       1075                1080                1085 

Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His Asp
   1090                1095                1100 

Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu Pro
1105               1110                1115                1120 

Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln Pro
               1125                1130                1135 

Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro Arg
           1140                1145                1150 

Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu Arg
       1155                1160                1165 

Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val Phe
   1170                1175                1180 

Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln Gly
1185               1190                1195                1200 

Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala Phe
               1205                1210                1215 

Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala Pro
           1220                1225                1230 

Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr Leu
       1235                1240                1245 

Gly Leu Asp Val Pro Val
   1250                


<210>    2
<211>    581
<212>    PRT
<213>    Homo sapiens

<400>    2
Met Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu
  1               5                  10                  15 

Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met
             20                  25                  30 

Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys
         35                  40                  45 

Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile
     50                  55                  60 

Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val
 65                  70                  75                  80 

Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu
                 85                  90                  95 

Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu
            100                 105                 110 

Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro
        115                 120                 125 

Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg Leu Gly
    130                 135                 140 

Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly Met Ser
145                 150                 155                 160 

Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn
                165                 170                 175 

Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu
            180                 185                 190 

Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp Gly Gly
        195                 200                 205 

Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg
    210                 215                 220 

Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu
225                 230                 235                 240 

Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg Glu
                245                 250                 255 

Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile
            260                 265                 270 

Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp
        275                 280                 285 

Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe Ser Arg
    290                 295                 300 

Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp Leu
305                 310                 315                 320 

Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu Leu Glu
                325                 330                 335 

Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu Val Pro
            340                 345                 350 

Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly Gly Met
        355                 360                 365 

Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly Gly Asp
    370                 375                 380 

Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg Ser Pro
385                 390                 395                 400 

Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly Asp Leu
                405                 410                 415 

Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His Asp Pro
            420                 425                 430 

Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu Pro Ser
        435                 440                 445 

Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln Pro Glu
    450                 455                 460 

Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro Arg Glu
465                 470                 475                 480 

Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu Arg Ala
                485                 490                 495 

Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val Phe Ala
            500                 505                 510 

Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln Gly Gly
        515                 520                 525 

Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala Phe Asp
    530                 535                 540 

Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala Pro Pro
545                 550                 555                 560 

Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr Leu Gly
                565                 570                 575 

Leu Asp Val Pro Val
            580    


<210>    3
<211>    1746
<212>    DNA
<213>    Homo sapiens

<400>    3
atgaagcgac ggcagcagaa gatccggaag tacacgatgc ggagactgct gcaggaaacg         60

gagctggtgg agccgctgac acctagcgga gcgatgccca accaggcgca gatgcggatc        120

ctgaaagaga cggagctgag gaaggtgaag gtgcttggat ctggcgcttt tggcacagtc        180

tacaagggca tctggatccc tgatggggag aatgtgaaaa ttccagtggc catcaaagtg        240

ttgagggaaa acacatcccc caaagccaac aaagaaatct tagacgaagc atacgtgatg        300

gctggtgtgg gctccccata tgtctcccgc cttctgggca tctgcctgac atccacggtg        360

cagctggtga cacagcttat gccctatggc tgcctcttag accatgtccg ggaaaaccgc        420

ggacgcctgg gctcccagga cctgctgaac tggtgtatgc agattgccaa ggggatgagc        480

tacctggagg atgtgcggct cgtacacagg gacttggccg ctcggaacgt gctggtcaag        540

agtcccaacc atgtcaaaat tacagacttc gggctggctc ggctgctgga cattgacgag        600

acagagtacc atgcagatgg gggcaaggtg cccatcaagt ggatggcgct ggagtccatt        660

ctccgccggc ggttcaccca ccagagtgat gtgtggagtt atggtgtgac tgtgtgggag        720

ctgatgactt ttggggccaa accttacgat gggatcccag cccgggagat ccctgacctg        780

ctggaaaagg gggagcggct gccccagccc cccatctgca ccattgatgt ctacatgatc        840

atggtcaaat gttggatgat tgactctgaa tgtcggccaa gattccggga gttggtgtct        900

gaattctccc gcatggccag ggacccccag cgctttgtgg tcatccagaa tgaggacttg        960

ggcccagcca gtcccttgga cagcaccttc taccgctcac tgctggagga cgatgacatg       1020

ggggacctgg tggatgctga ggagtatctg gtaccccagc agggcttctt ctgtccagac       1080

cctgccccgg gcgctggggg catggtccac cacaggcacc gcagctcatc taccaggagt       1140

ggcggtgggg acctgacact agggctggag ccctctgaag aggaggcccc caggtctcca       1200

ctggcaccct ccgaaggggc tggctccgat gtatttgatg gtgacctggg aatgggggca       1260

gccaaggggc tgcaaagcct ccccacacat gaccccagcc ctctacagcg gtacagtgag       1320

gaccccacag tacccctgcc ctctgagact gatggctacg ttgcccccct gacctgcagc       1380

ccccagcctg aatatgtgaa ccagccagat gttcggcccc agcccccttc gccccgagag       1440

ggccctctgc ctgctgcccg acctgctggt gccactctgg aaagggccaa gactctctcc       1500

ccagggaaga atggggtcgt caaagacgtt tttgcctttg ggggtgccgt ggagaacccc       1560

gagtacttga caccccaggg aggagctgcc cctcagcccc accctcctcc tgccttcagc       1620

ccagccttcg acaacctcta ttactgggac caggacccac cagagcgggg ggctccaccc       1680

agcaccttca aagggacacc tacggcagag aacccagagt acctgggtct ggacgtgcca       1740

gtgtaa                                                                  1746
