                         SEQUENCE LISTING

<110>  Pfizer Inc.
 
<120>  Vaccination against bacterial and betacoronavirus

<130>  PC072752A

<140>  63/183,630
<141>  2021-05-03

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  4284
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1
gagaauaaac uaguauucuu cuggucccca cagacucaga gagaacccgc caccauguuc       60

guguuccugg ugcugcugcc ucuggugucc agccagugug ugaaccugac caccagaaca      120

cagcugccuc cagccuacac caacagcuuu accagaggcg uguacuaccc cgacaaggug      180

uucagaucca gcgugcugca cucuacccag gaccuguucc ugccuuucuu cagcaacgug      240

accugguucc acgccaucca cguguccggc accaauggca ccaagagauu cgacaacccc      300

gugcugcccu ucaacgacgg gguguacuuu gccagcaccg agaaguccaa caucaucaga      360

ggcuggaucu ucggcaccac acuggacagc aagacccaga gccugcugau cgugaacaac      420

gccaccaacg uggucaucaa agugugcgag uuccaguucu gcaacgaccc cuuccugggc      480

gucuacuacc acaagaacaa caagagcugg auggaaagcg aguuccgggu guacagcagc      540

gccaacaacu gcaccuucga guacgugucc cagccuuucc ugauggaccu ggaaggcaag      600

cagggcaacu ucaagaaccu gcgcgaguuc guguuuaaga acaucgacgg cuacuucaag      660

aucuacagca agcacacccc uaucaaccuc gugcgggauc ugccucaggg cuucucugcu      720

cuggaacccc ugguggaucu gcccaucggc aucaacauca cccgguuuca gacacugcug      780

gcccugcaca gaagcuaccu gacaccuggc gauagcagca gcggauggac agcuggugcc      840

gccgcuuacu augugggcua ccugcagccu agaaccuucc ugcugaagua caacgagaac      900

ggcaccauca ccgacgccgu ggauugugcu cuggauccuc ugagcgagac aaagugcacc      960

cugaaguccu ucaccgugga aaagggcauc uaccagacca gcaacuuccg ggugcagccc     1020

accgaaucca ucgugcgguu ccccaauauc accaaucugu gccccuucgg cgagguguuc     1080

aaugccacca gauucgccuc uguguacgcc uggaaccgga agcggaucag caauugcgug     1140

gccgacuacu ccgugcugua caacuccgcc agcuucagca ccuucaagug cuacggcgug     1200

uccccuacca agcugaacga ccugugcuuc acaaacgugu acgccgacag cuucgugauc     1260

cggggagaug aagugcggca gauugccccu ggacagacag gcaagaucgc cgacuacaac     1320

uacaagcugc ccgacgacuu caccggcugu gugauugccu ggaacagcaa caaccuggac     1380

uccaaagucg gcggcaacua caauuaccug uaccggcugu uccggaaguc caaucugaag     1440

cccuucgagc gggacaucuc caccgagauc uaucaggccg gcagcacccc uuguaacggc     1500

guggaaggcu ucaacugcua cuucccacug caguccuacg gcuuucagcc cacaaauggc     1560

gugggcuauc agcccuacag agugguggug cugagcuucg aacugcugca ugccccugcc     1620

acagugugcg gcccuaagaa aagcaccaau cucgugaaga acaaaugcgu gaacuucaac     1680

uucaacggcc ugaccggcac cggcgugcug acagagagca acaagaaguu ccugccauuc     1740

cagcaguuug gccgggauau cgccgauacc acagacgccg uuagagaucc ccagacacug     1800

gaaauccugg acaucacccc uugcagcuuc ggcggagugu cugugaucac cccuggcacc     1860

aacaccagca aucagguggc agugcuguac caggacguga acuguaccga agugcccgug     1920

gccauucacg ccgaucagcu gacaccuaca uggcgggugu acuccaccgg cagcaaugug     1980

uuucagacca gagccggcug ucugaucgga gccgagcacg ugaacaauag cuacgagugc     2040

gacaucccca ucggcgcugg aaucugcgcc agcuaccaga cacagacaaa cagcccucgg     2100

agagccagaa gcguggccag ccagagcauc auugccuaca caaugucucu gggcgccgag     2160

aacagcgugg ccuacuccaa caacucuauc gcuaucccca ccaacuucac caucagcgug     2220

accacagaga uccugccugu guccaugacc aagaccagcg uggacugcac cauguacauc     2280

ugcggcgauu ccaccgagug cuccaaccug cugcugcagu acggcagcuu cugcacccag     2340

cugaauagag cccugacagg gaucgccgug gaacaggaca agaacaccca agagguguuc     2400

gcccaaguga agcagaucua caagaccccu ccuaucaagg acuucggcgg cuucaauuuc     2460

agccagauuc ugcccgaucc uagcaagccc agcaagcgga gcuucaucga ggaccugcug     2520

uucaacaaag ugacacuggc cgacgccggc uucaucaagc aguauggcga uugucugggc     2580

gacauugccg ccagggaucu gauuugcgcc cagaaguuua acggacugac agugcugccu     2640

ccucugcuga ccgaugagau gaucgcccag uacacaucug cccugcuggc cggcacaauc     2700

acaagcggcu ggacauuugg agcaggcgcc gcucugcaga uccccuuugc uaugcagaug     2760

gccuaccggu ucaacggcau cggagugacc cagaaugugc uguacgagaa ccagaagcug     2820

aucgccaacc aguucaacag cgccaucggc aagauccagg acagccugag cagcacagca     2880

agcgcccugg gaaagcugca ggacgugguc aaccagaaug cccaggcacu gaacacccug     2940

gucaagcagc uguccuccaa cuucggcgcc aucagcucug ugcugaacga uauccugagc     3000

agacuggacc cuccugaggc cgaggugcag aucgacagac ugaucacagg cagacugcag     3060

agccuccaga cauacgugac ccagcagcug aucagagccg ccgagauuag agccucugcc     3120

aaucuggccg ccaccaagau gucugagugu gugcugggcc agagcaagag aguggacuuu     3180

ugcggcaagg gcuaccaccu gaugagcuuc ccucagucug ccccucacgg cgugguguuu     3240

cugcacguga cauaugugcc cgcucaagag aagaauuuca ccaccgcucc agccaucugc     3300

cacgacggca aagcccacuu uccuagagaa ggcguguucg uguccaacgg cacccauugg     3360

uucgugacac agcggaacuu cuacgagccc cagaucauca ccaccgacaa caccuucgug     3420

ucuggcaacu gcgacgucgu gaucggcauu gugaacaaua ccguguacga cccucugcag     3480

cccgagcugg acagcuucaa agaggaacug gacaaguacu uuaagaacca cacaagcccc     3540

gacguggacc ugggcgauau cagcggaauc aaugccagcg ucgugaacau ccagaaagag     3600

aucgaccggc ugaacgaggu ggccaagaau cugaacgaga gccugaucga ccugcaagaa     3660

cuggggaagu acgagcagua caucaagugg cccugguaca ucuggcuggg cuuuaucgcc     3720

ggacugauug ccaucgugau ggucacaauc augcuguguu gcaugaccag cugcuguagc     3780

ugccugaagg gcuguuguag cuguggcagc ugcugcaagu ucgacgagga cgauucugag     3840

cccgugcuga agggcgugaa acugcacuac acaugaugac ucgagcuggu acugcaugca     3900

cgcaaugcua gcugccccuu ucccguccug gguaccccga gucucccccg accucggguc     3960

ccagguaugc ucccaccucc accugcccca cucaccaccu cugcuaguuc cagacaccuc     4020

ccaagcacgc agcaaugcag cucaaaacgc uuagccuagc cacaccccca cgggaaacag     4080

cagugauuaa ccuuuagcaa uaaacgaaag uuuaacuaag cuauacuaac cccaggguug     4140

gucaauuucg ugccagccac acccuggagc uagcaaaaaa aaaaaaaaaa aaaaaaaaaa     4200

aaaagcauau gacuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4260

aaaaaaaaaa aaaaaaaaaa aaaa                                            4284


<210>  2
<211>  4001
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2
gggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cgccaccaug       60

uucguguucc uggugcugcu gccccuggug agcagccagu gcgugaaccu gaccacccgg      120

acccagcugc caccagccua caccaacagc uucacccggg gcgucuacua ccccgacaag      180

guguuccgga gcagcguccu gcacagcacc caggaccugu uccugcccuu cuucagcaac      240

gugaccuggu uccacgccau ccacgugagc ggcaccaacg gcaccaagcg guucgacaac      300

cccgugcugc ccuucaacga cggcguguac uucgccagca ccgagaagag caacaucauc      360

cggggcugga ucuucggcac cacccuggac agcaagaccc agagccugcu gaucgugaau      420

aacgccacca acguggugau caaggugugc gaguuccagu ucugcaacga ccccuuccug      480

ggcguguacu accacaagaa caacaagagc uggauggaga gcgaguuccg gguguacagc      540

agcgccaaca acugcaccuu cgaguacgua gagccagccc uuccugaugg accuggaggg      600

caagcagggc aacuucaaga accugcggga guucguguuc aagaacaucg acggcuacuu      660

caagaucuac agcaagcaca ccccaaucaa ccuggugcgg gaucugcccc agggcuucuc      720

agcccuggag ccccuggugg accugcccau cggcaucaac aucacccggu uccagacccu      780

gcuggcccug caccggagcu accugacccc aggcgacagc agcagcgggu ggacagcagg      840

cgcggcugcu uacuacgugg gcuaccugca gccccggacc uuccugcuga aguacaacga      900

gaacggcacc aucaccgacg ccguggacug cgcccuggac ccucugagcg agaccaagug      960

cacccugaag agcuucaccg uggagaaggg caucuaccag accagcaacu uccgggugca     1020

gcccaccgag agcaucgugc gguuccccaa caucaccaac cugugccccu ucggcgaggu     1080

guucaacgcc acccgguucg ccagcgugua cgccuggaac cggaagcgga ucagcaacug     1140

cguggccgac uacagcgugc uguacaacag cgccagcuuc agcaccuuca agugcuacgg     1200

cgugagcccc accaagcuga acgaccuguc uucaccaacg uguacgccga caguucguga     1260

uccguggcga cgaggugcgg cagaucgcac ccggccagac aggcaagauc gccgacuaca     1320

acuacaagcu gcccgacgac uucaccggcu gcgugaucgc cuggaacagc aacaaccucg     1380

acagcaaggu gggcggcaac uacaacuacc uguaccggcu guuccggaag agcaaccuga     1440

agcccuucga gcgggacauc agcaccgaga ucuaccaagc cggcuccacc ccuugcaacg     1500

gcguggaggg cuucaacugc uacuucccuc ugcagagcua cggcuuccag cccaccaacg     1560

gcgugggcua ccagcccuac cggguggugg ugcugagcuu cgagcugcug cacgccccag     1620

ccaccgugug uggccccaag aagagcacca accuggugaa gaacaagugc gugaacuuca     1680

acuucaacgg ccuuaccggc accggcgugc ugaccgagag caacaagaaa uuccugcccu     1740

uucagcaguu cggccgggac aucgccgaca ccaccgacgc ugugcgggau ccccagaccc     1800

uggagauccu ggacaucacc ccuugcagcu ucggcggcgu gagcgugauc accccaggca     1860

ccaacaccag caaccaggug gccgugcugu accaggacgu gaacugcacc gaggugcccg     1920

uggccaucca cgccgaccag cugacaccca ccuggcgggu cuacagcacc ggcagcaacg     1980

uguuccagac ccgggccggu ugccugaucg gcgccgagca cgugaacaac agcuacgagu     2040

gcgacauccc caucggcgcc ggcaucugug ccagcuacca gacccagacc aauucacccc     2100

ggagggcaag gagcguggcc agccagagca ucaucgccua caccaugagc cugggcgccg     2160

agaacagcgu ggccuacagc aacaacagca ucgccauccc caccaacuuc accaucagcg     2220

ugaccaccga gauucugccc gugagcauga ccaagaccag cguggacugc accauguaca     2280

ucugcggcga cagcaccgag ugcagcaacc ugcugcugca guacggcagc uucugcaccc     2340

agcugaaccg ggcccugacc ggcaucgccg uggagcagga caagaacacc caggaggugu     2400

ucgcccaggu gaagcagauc uacaagaccc cucccaucaa ggacuucggc ggcuucaauu     2460

cagccagauc cugcccgacc ccagcaagcc cagcaagcgg agcuucaucg aggaccugcu     2520

guucaacaag gugacccuag ccgacgccgg cuucaucaag caguacggcg acugccucgg     2580

cgacauagcc gcccgggacc ugaucugcgc ccagaaguuc aacggccuga ccgugcugcc     2640

uccccugcug accgacgaga ugaucgccca guacaccagc gccuguuagc cggaaccauc     2700

accagcggcu ggacuuucgg cgcuggagcc gcucugcaga uccccuucgc caugcagaug     2760

gccuaccggu ucaacggcau cggcgugacc cagaacgugc uguacgagaa ccagaagcug     2820

aucgccaacc aguucaacag cgccaucggc aagauccagg acagccugag cagcaccgcu     2880

agcgcccugg gcaagcugca ggacguggug aaccagaacg cccaggcccu gaacacccug     2940

gugaagcagc ugagcagcaa cuucggcgcc aucagcagcg ugcugaacga cauccugagc     3000

cggcuggacc cucccgaggc cgaggugcag aucgaccggc ugaucacugg ccggcugcag     3060

agccugcaga ccuacgugac ccagcagcug auccgggccg ccgagauucg ggccagcgcc     3120

aaccuggccg ccaccaagau gagcgagugc gugcugggcc agagcaagcg gguggacuuc     3180

ugcggcaagg gcuaccaccu gaugagcuuu ccccagagcg caccccacgg agugguguuc     3240

cugcacguga ccuacgugcc cgcccaggag aagaacuuca ccaccgcccc agccaucugc     3300

cacgacggca aggcccacuu uccccgggag ggcguguucg ugagcaacgg cacccacugg     3360

uucgugaccc agcggaacuu cuacgagccc cagaucauca ccaccgacaa caccuucgug     3420

agcggcaacu gcgacguggu gaucggcauc gugaacaaca ccguguacga uccccugcag     3480

cccgagcugg acagcuucaa ggaggagcug gacaaguacu ucaagaauca caccagcccc     3540

gacguggacc ugggcgacau cagcggcauc aacgccagcg uggugaacau ccagaaggag     3600

aucgaucggc ugaacgaggu ggccaagaac cugaacgaga gccugaucga ccugcaggag     3660

cugggcaagu acgagcagua caucaagugg cccugguaca ucuggcuggg cuucaucgcc     3720

ggccugaucg ccaucgugau ggugaccauc augcugugcu gcaugaccag cugcugcagc     3780

ugccugaagg gcuguugcag cugcggcagc ugcugcaagu ucgacgagga cgacagcgag     3840

cccgugcuga agggcgugaa gcugcacuac accugauaau aggcuggagc cucgguggcc     3900

uagcuucuug ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc     3960

cguggucuuu gaauaaaguc ugagugggcg gcaaaaaaaa a                         4001


<210>  3
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Cys Gly Ser Ser Gly Gly Gly Gly Val Ala Ala Asp Ile Gly Thr Gly 
1               5                   10                  15      


Leu Ala Asp Ala Leu Thr Ala Pro Leu Asp His Lys Asp Lys Gly Leu 
            20                  25                  30          


Lys Ser Leu Thr Leu Glu Asp Ser Ile Ser Gln Asn Gly Thr Leu Thr 
        35                  40                  45              


Leu Ser Ala Gln Gly Ala Glu Lys Thr Phe Lys Val Gly Asp Lys Asp 
    50                  55                  60                  


Asn Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp Lys Ile Ser Arg Phe 
65                  70                  75                  80  


Asp Phe Val Gln Lys Ile Glu Val Asp Gly Gln Thr Ile Thr Leu Ala 
                85                  90                  95      


Ser Gly Glu Phe Gln Ile Tyr Lys Gln Asp His Ser Ala Val Val Ala 
            100                 105                 110         


Leu Gln Ile Glu Lys Ile Asn Asn Pro Asp Lys Ile Asp Ser Leu Ile 
        115                 120                 125             


Asn Gln Arg Ser Phe Leu Val Ser Gly Leu Gly Gly Glu His Thr Ala 
    130                 135                 140                 


Phe Asn Gln Leu Pro Ser Gly Lys Ala Glu Tyr His Gly Lys Ala Phe 
145                 150                 155                 160 


Ser Ser Asp Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile Asp Phe Ala 
                165                 170                 175     


Ala Lys Gln Gly His Gly Lys Ile Glu His Leu Lys Thr Pro Glu Gln 
            180                 185                 190         


Asn Val Glu Leu Ala Ser Ala Glu Leu Lys Ala Asp Glu Lys Ser His 
        195                 200                 205             


Ala Val Ile Leu Gly Asp Thr Arg Tyr Gly Ser Glu Glu Lys Gly Thr 
    210                 215                 220                 


Tyr His Leu Ala Leu Phe Gly Asp Arg Ala Gln Glu Ile Ala Gly Ser 
225                 230                 235                 240 


Ala Thr Val Lys Ile Arg Glu Lys Val His Glu Ile Gly Ile Ala Gly 
                245                 250                 255     


Lys Gln 
        


<210>  4
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

Cys Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Val Thr Ala 
1               5                   10                  15      


Asp Ile Gly Thr Gly Leu Ala Asp Ala Leu Thr Ala Pro Leu Asp His 
            20                  25                  30          


Lys Asp Lys Gly Leu Lys Ser Leu Thr Leu Glu Asp Ser Ile Ser Gln 
        35                  40                  45              


Asn Gly Thr Leu Thr Leu Ser Ala Gln Gly Ala Glu Lys Thr Tyr Gly 
    50                  55                  60                  


Asn Gly Asp Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp Lys Val Ser 
65                  70                  75                  80  


Arg Phe Asp Phe Ile Arg Gln Ile Glu Val Asp Gly Gln Leu Ile Thr 
                85                  90                  95      


Leu Glu Ser Gly Glu Phe Gln Val Tyr Lys Gln Ser His Ser Ala Leu 
            100                 105                 110         


Thr Ala Leu Gln Thr Glu Gln Glu Gln Asp Pro Glu His Ser Glu Lys 
        115                 120                 125             


Met Val Ala Lys Arg Arg Phe Arg Ile Gly Asp Ile Ala Gly Glu His 
    130                 135                 140                 


Thr Ser Phe Asp Lys Leu Pro Lys Asp Val Met Ala Thr Tyr Arg Gly 
145                 150                 155                 160 


Thr Ala Phe Gly Ser Asp Asp Ala Gly Gly Lys Leu Thr Tyr Thr Ile 
                165                 170                 175     


Asp Phe Ala Ala Lys Gln Gly His Gly Lys Ile Glu His Leu Lys Ser 
            180                 185                 190         


Pro Glu Leu Asn Val Asp Leu Ala Val Ala Tyr Ile Lys Pro Asp Glu 
        195                 200                 205             


Lys His His Ala Val Ile Ser Gly Ser Val Leu Tyr Asn Gln Asp Glu 
    210                 215                 220                 


Lys Gly Ser Tyr Ser Leu Gly Ile Phe Gly Glu Lys Ala Gln Glu Val 
225                 230                 235                 240 


Ala Gly Ser Ala Glu Val Glu Thr Ala Asn Gly Ile His His Ile Gly 
                245                 250                 255     


Leu Ala Ala Lys Gln 
            260     


<210>  5
<211>  2699
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5

Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile Arg 
1               5                   10                  15      


Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu Tyr 
            20                  25                  30          


Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu Lys 
        35                  40                  45              


Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr Ser 
    50                  55                  60                  


Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys Glu 
65                  70                  75                  80  


Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn Leu 
                85                  90                  95      


His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu Tyr 
            100                 105                 110         


Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu Trp 
        115                 120                 125             


Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile Val 
    130                 135                 140                 


Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile Gln 
145                 150                 155                 160 


Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu Phe 
                165                 170                 175     


Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln Ile 
            180                 185                 190         


Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His Leu 
        195                 200                 205             


Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg Thr 
    210                 215                 220                 


Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg Ala 
225                 230                 235                 240 


Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln Glu 
                245                 250                 255     


Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg Leu 
            260                 265                 270         


Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Ala Val Ala Met Leu 
        275                 280                 285             


Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser Ser 
    290                 295                 300                 


Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met Lys 
305                 310                 315                 320 


Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys Leu 
                325                 330                 335     


Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys Ser 
            340                 345                 350         


Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser Asp 
        355                 360                 365             


Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln Ala 
    370                 375                 380                 


Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu Gln 
385                 390                 395                 400 


Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala Ile 
                405                 410                 415     


Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp Ser 
            420                 425                 430         


Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys Ile 
        435                 440                 445             


Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr Ile 
    450                 455                 460                 


Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe Ile 
465                 470                 475                 480 


Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp Leu 
                485                 490                 495     


Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu Gln 
            500                 505                 510         


Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr Gln 
        515                 520                 525             


Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu Asp 
    530                 535                 540                 


Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr Leu 
545                 550                 555                 560 


Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser Lys 
                565                 570                 575     


Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser Tyr 
            580                 585                 590         


Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile Ile 
        595                 600                 605             


Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser Asp 
    610                 615                 620                 


Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu Arg 
625                 630                 635                 640 


Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly Lys 
                645                 650                 655     


Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser Leu 
            660                 665                 670         


Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile Ser 
        675                 680                 685             


Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr 
    690                 695                 700                 


Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser Ile 
705                 710                 715                 720 


Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser Ile 
                725                 730                 735     


Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg 
            740                 745                 750         


Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu Ala 
        755                 760                 765             


Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile 
    770                 775                 780                 


Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser 
785                 790                 795                 800 


Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro 
                805                 810                 815     


Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser 
            820                 825                 830         


Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile 
        835                 840                 845             


Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu 
    850                 855                 860                 


Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp 
865                 870                 875                 880 


Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr 
                885                 890                 895     


Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val 
            900                 905                 910         


Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys 
        915                 920                 925             


Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn 
    930                 935                 940                 


Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu 
945                 950                 955                 960 


Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys 
                965                 970                 975     


Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala 
            980                 985                 990         


Gln Leu Phe Ser Thr Gly Leu Asn  Thr Ile Tyr Asp Ser  Ile Gln Leu 
        995                 1000                 1005             


Val Asn  Leu Ile Ser Asn Ala  Val Asn Asp Thr Ile  Asn Val Leu 
    1010                 1015                 1020             


Pro Thr  Ile Thr Glu Gly Ile  Pro Ile Val Ser Thr  Ile Leu Asp 
    1025                 1030                 1035             


Gly Ile  Asn Leu Gly Ala Ala  Ile Lys Glu Leu Leu  Asp Glu His 
    1040                 1045                 1050             


Asp Pro  Leu Leu Lys Lys Glu  Leu Glu Ala Lys Val  Gly Val Leu 
    1055                 1060                 1065             


Ala Ile  Asn Met Ser Leu Ser  Ile Ala Ala Thr Val  Ala Ser Ile 
    1070                 1075                 1080             


Val Gly  Ile Gly Ala Glu Val  Thr Ile Phe Leu Leu  Pro Ile Ala 
    1085                 1090                 1095             


Gly Ile  Ser Ala Gly Ile Pro  Ser Leu Val Asn Asn  Glu Leu Ile 
    1100                 1105                 1110             


Leu His  Asp Lys Ala Thr Ser  Val Val Asn Tyr Phe  Asn His Leu 
    1115                 1120                 1125             


Ser Glu  Ser Lys Lys Tyr Gly  Pro Leu Lys Thr Glu  Asp Asp Lys 
    1130                 1135                 1140             


Ile Leu  Val Pro Ile Asp Asp  Leu Val Ile Ser Glu  Ile Asp Phe 
    1145                 1150                 1155             


Asn Asn  Asn Ser Ile Lys Leu  Gly Thr Cys Asn Ile  Leu Ala Met 
    1160                 1165                 1170             


Glu Gly  Gly Ser Gly His Thr  Val Thr Gly Asn Ile  Asp His Phe 
    1175                 1180                 1185             


Phe Ser  Ser Pro Ser Ile Ser  Ser His Ile Pro Ser  Leu Ser Ile 
    1190                 1195                 1200             


Tyr Ser  Ala Ile Gly Ile Glu  Thr Glu Asn Leu Asp  Phe Ser Lys 
    1205                 1210                 1215             


Lys Ile  Met Met Leu Pro Asn  Ala Pro Ser Arg Val  Phe Trp Trp 
    1220                 1225                 1230             


Glu Thr  Gly Ala Val Pro Gly  Leu Arg Ser Leu Glu  Asn Asp Gly 
    1235                 1240                 1245             


Thr Arg  Leu Leu Asp Ser Ile  Arg Asp Leu Tyr Pro  Gly Lys Phe 
    1250                 1255                 1260             


Tyr Trp  Arg Phe Tyr Ala Phe  Phe Asp Tyr Ala Ile  Thr Thr Leu 
    1265                 1270                 1275             


Lys Pro  Val Tyr Glu Asp Thr  Asn Ile Lys Ile Lys  Leu Asp Lys 
    1280                 1285                 1290             


Asp Thr  Arg Asn Phe Ile Met  Pro Thr Ile Thr Thr  Asn Glu Ile 
    1295                 1300                 1305             


Arg Asn  Lys Leu Ser Tyr Ser  Phe Asp Gly Ala Gly  Gly Thr Tyr 
    1310                 1315                 1320             


Ser Leu  Leu Leu Ser Ser Tyr  Pro Ile Ser Thr Asn  Ile Asn Leu 
    1325                 1330                 1335             


Ser Lys  Asp Asp Leu Trp Ile  Phe Asn Ile Asp Asn  Glu Val Arg 
    1340                 1345                 1350             


Glu Ile  Ser Ile Glu Asn Gly  Thr Ile Lys Lys Gly  Lys Leu Ile 
    1355                 1360                 1365             


Lys Asp  Val Leu Ser Lys Ile  Asp Ile Asn Lys Asn  Lys Leu Ile 
    1370                 1375                 1380             


Ile Gly  Asn Gln Thr Ile Asp  Phe Ser Gly Asp Ile  Asp Asn Lys 
    1385                 1390                 1395             


Asp Arg  Tyr Ile Phe Leu Thr  Cys Glu Leu Asp Asp  Lys Ile Ser 
    1400                 1405                 1410             


Leu Ile  Ile Glu Ile Asn Leu  Val Ala Lys Ser Tyr  Ser Leu Leu 
    1415                 1420                 1425             


Leu Ser  Gly Asp Lys Asn Tyr  Leu Ile Ser Asn Leu  Ser Asn Ile 
    1430                 1435                 1440             


Ile Glu  Lys Ile Asn Thr Leu  Gly Leu Asp Ser Lys  Asn Ile Ala 
    1445                 1450                 1455             


Tyr Asn  Tyr Thr Asp Glu Ser  Asn Asn Lys Tyr Phe  Gly Ala Ile 
    1460                 1465                 1470             


Ser Lys  Thr Ser Gln Lys Ser  Ile Ile His Tyr Lys  Lys Asp Ser 
    1475                 1480                 1485             


Lys Asn  Ile Leu Glu Phe Tyr  Asn Asp Ser Thr Leu  Glu Phe Asn 
    1490                 1495                 1500             


Ser Lys  Asp Phe Ile Ala Glu  Asp Ile Asn Val Phe  Met Lys Asp 
    1505                 1510                 1515             


Asp Ile  Asn Thr Ile Thr Gly  Lys Tyr Tyr Val Asp  Asn Asn Thr 
    1520                 1525                 1530             


Asp Lys  Ser Ile Asp Phe Ser  Ile Ser Leu Val Ser  Lys Asn Gln 
    1535                 1540                 1545             


Val Lys  Val Asn Gly Leu Tyr  Leu Asn Glu Ser Val  Tyr Ser Ser 
    1550                 1555                 1560             


Tyr Leu  Asp Phe Val Lys Asn  Ser Asp Gly His His  Asn Thr Ser 
    1565                 1570                 1575             


Asn Phe  Met Asn Leu Phe Leu  Asp Asn Ile Ser Phe  Trp Lys Leu 
    1580                 1585                 1590             


Phe Gly  Phe Glu Asn Ile Asn  Phe Val Ile Asp Lys  Tyr Phe Thr 
    1595                 1600                 1605             


Leu Val  Gly Lys Thr Asn Leu  Gly Tyr Val Glu Phe  Ile Cys Asp 
    1610                 1615                 1620             


Asn Asn  Lys Asn Ile Asp Ile  Tyr Phe Gly Glu Trp  Lys Thr Ser 
    1625                 1630                 1635             


Ser Ser  Lys Ser Thr Ile Phe  Ser Gly Asn Gly Arg  Asn Val Val 
    1640                 1645                 1650             


Val Glu  Pro Ile Tyr Asn Pro  Asp Thr Gly Glu Asp  Ile Ser Thr 
    1655                 1660                 1665             


Ser Leu  Asp Phe Ser Tyr Glu  Pro Leu Tyr Gly Ile  Asp Arg Tyr 
    1670                 1675                 1680             


Ile Asn  Lys Val Leu Ile Ala  Pro Asp Leu Tyr Thr  Ser Leu Ile 
    1685                 1690                 1695             


Asn Ile  Asn Thr Asn Tyr Tyr  Ser Asn Glu Tyr Tyr  Pro Glu Ile 
    1700                 1705                 1710             


Ile Val  Leu Asn Pro Asn Thr  Phe His Lys Lys Val  Asn Ile Asn 
    1715                 1720                 1725             


Leu Asp  Ser Ser Ser Phe Glu  Tyr Lys Trp Ser Thr  Glu Gly Ser 
    1730                 1735                 1740             


Asp Phe  Ile Leu Val Arg Tyr  Leu Glu Glu Ser Asn  Lys Lys Ile 
    1745                 1750                 1755             


Leu Gln  Lys Ile Arg Ile Lys  Gly Ile Leu Ser Asn  Thr Gln Ser 
    1760                 1765                 1770             


Phe Asn  Lys Met Ser Ile Asp  Phe Lys Asp Ile Lys  Lys Leu Ser 
    1775                 1780                 1785             


Leu Gly  Tyr Ile Met Ser Asn  Phe Lys Ser Phe Asn  Ser Glu Asn 
    1790                 1795                 1800             


Glu Leu  Asp Arg Asp His Leu  Gly Phe Lys Ile Ile  Asp Asn Lys 
    1805                 1810                 1815             


Thr Tyr  Tyr Tyr Asp Glu Asp  Ser Lys Leu Val Lys  Gly Leu Ile 
    1820                 1825                 1830             


Asn Ile  Asn Asn Ser Leu Phe  Tyr Phe Asp Pro Ile  Glu Phe Asn 
    1835                 1840                 1845             


Leu Val  Thr Gly Trp Gln Thr  Ile Asn Gly Lys Lys  Tyr Tyr Phe 
    1850                 1855                 1860             


Asp Ile  Asn Thr Gly Ala Ala  Leu Ile Ser Tyr Lys  Ile Ile Asn 
    1865                 1870                 1875             


Gly Lys  His Phe Tyr Phe Asn  Asn Asp Gly Val Met  Gln Leu Gly 
    1880                 1885                 1890             


Val Phe  Lys Gly Pro Asp Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    1895                 1900                 1905             


Thr Gln  Asn Asn Asn Ile Glu  Gly Gln Ala Ile Val  Tyr Gln Ser 
    1910                 1915                 1920             


Lys Phe  Leu Thr Leu Asn Gly  Lys Lys Tyr Tyr Phe  Asp Asn Asp 
    1925                 1930                 1935             


Ser Lys  Ala Val Thr Gly Trp  Arg Ile Ile Asn Asn  Glu Lys Tyr 
    1940                 1945                 1950             


Tyr Phe  Asn Pro Asn Asn Ala  Ile Ala Ala Val Gly  Leu Gln Val 
    1955                 1960                 1965             


Ile Asp  Asn Asn Lys Tyr Tyr  Phe Asn Pro Asp Thr  Ala Ile Ile 
    1970                 1975                 1980             


Ser Lys  Gly Trp Gln Thr Val  Asn Gly Ser Arg Tyr  Tyr Phe Asp 
    1985                 1990                 1995             


Thr Asp  Thr Ala Ile Ala Phe  Asn Gly Tyr Lys Thr  Ile Asp Gly 
    2000                 2005                 2010             


Lys His  Phe Tyr Phe Asp Ser  Asp Cys Val Val Lys  Ile Gly Val 
    2015                 2020                 2025             


Phe Ser  Thr Ser Asn Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    2030                 2035                 2040             


Tyr Asn  Asn Asn Ile Glu Gly  Gln Ala Ile Val Tyr  Gln Ser Lys 
    2045                 2050                 2055             


Phe Leu  Thr Leu Asn Gly Lys  Lys Tyr Tyr Phe Asp  Asn Asn Ser 
    2060                 2065                 2070             


Lys Ala  Val Thr Gly Trp Gln  Thr Ile Asp Ser Lys  Lys Tyr Tyr 
    2075                 2080                 2085             


Phe Asn  Thr Asn Thr Ala Glu  Ala Ala Thr Gly Trp  Gln Thr Ile 
    2090                 2095                 2100             


Asp Gly  Lys Lys Tyr Tyr Phe  Asn Thr Asn Thr Ala  Glu Ala Ala 
    2105                 2110                 2115             


Thr Gly  Trp Gln Thr Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr 
    2120                 2125                 2130             


Asn Thr  Ala Ile Ala Ser Thr  Gly Tyr Thr Ile Ile  Asn Gly Lys 
    2135                 2140                 2145             


His Phe  Tyr Phe Asn Thr Asp  Gly Ile Met Gln Ile  Gly Val Phe 
    2150                 2155                 2160             


Lys Gly  Pro Asn Gly Phe Glu  Tyr Phe Ala Pro Ala  Asn Thr Asp 
    2165                 2170                 2175             


Ala Asn  Asn Ile Glu Gly Gln  Ala Ile Leu Tyr Gln  Asn Glu Phe 
    2180                 2185                 2190             


Leu Thr  Leu Asn Gly Lys Lys  Tyr Tyr Phe Gly Ser  Asp Ser Lys 
    2195                 2200                 2205             


Ala Val  Thr Gly Trp Arg Ile  Ile Asn Asn Lys Lys  Tyr Tyr Phe 
    2210                 2215                 2220             


Asn Pro  Asn Asn Ala Ile Ala  Ala Ile His Leu Cys  Thr Ile Asn 
    2225                 2230                 2235             


Asn Asp  Lys Tyr Tyr Phe Ser  Tyr Asp Gly Ile Leu  Gln Asn Gly 
    2240                 2245                 2250             


Tyr Ile  Thr Ile Glu Arg Asn  Asn Phe Tyr Phe Asp  Ala Asn Asn 
    2255                 2260                 2265             


Glu Ser  Lys Met Val Thr Gly  Val Phe Lys Gly Pro  Asn Gly Phe 
    2270                 2275                 2280             


Glu Tyr  Phe Ala Pro Ala Asn  Thr His Asn Asn Asn  Ile Glu Gly 
    2285                 2290                 2295             


Gln Ala  Ile Val Tyr Gln Asn  Lys Phe Leu Thr Leu  Asn Gly Lys 
    2300                 2305                 2310             


Lys Tyr  Tyr Phe Asp Asn Asp  Ser Lys Ala Val Thr  Gly Trp Gln 
    2315                 2320                 2325             


Thr Ile  Asp Gly Lys Lys Tyr  Tyr Phe Asn Leu Asn  Thr Ala Glu 
    2330                 2335                 2340             


Ala Ala  Thr Gly Trp Gln Thr  Ile Asp Gly Lys Lys  Tyr Tyr Phe 
    2345                 2350                 2355             


Asn Leu  Asn Thr Ala Glu Ala  Ala Thr Gly Trp Gln  Thr Ile Asp 
    2360                 2365                 2370             


Gly Lys  Lys Tyr Tyr Phe Asn  Thr Asn Thr Phe Ile  Ala Ser Thr 
    2375                 2380                 2385             


Gly Tyr  Thr Ser Ile Asn Gly  Lys His Phe Tyr Phe  Asn Thr Asp 
    2390                 2395                 2400             


Gly Ile  Met Gln Ile Gly Val  Phe Lys Gly Pro Asn  Gly Phe Glu 
    2405                 2410                 2415             


Tyr Phe  Ala Pro Ala Asn Thr  His Asn Asn Asn Ile  Glu Gly Gln 
    2420                 2425                 2430             


Ala Ile  Leu Tyr Gln Asn Lys  Phe Leu Thr Leu Asn  Gly Lys Lys 
    2435                 2440                 2445             


Tyr Tyr  Phe Gly Ser Asp Ser  Lys Ala Val Thr Gly  Leu Arg Thr 
    2450                 2455                 2460             


Ile Asp  Gly Lys Lys Tyr Tyr  Phe Asn Thr Asn Thr  Ala Val Ala 
    2465                 2470                 2475             


Val Thr  Gly Trp Gln Thr Ile  Asn Gly Lys Lys Tyr  Tyr Phe Asn 
    2480                 2485                 2490             


Thr Asn  Thr Ser Ile Ala Ser  Thr Gly Tyr Thr Ile  Ile Ser Gly 
    2495                 2500                 2505             


Lys His  Phe Tyr Phe Asn Thr  Asp Gly Ile Met Gln  Ile Gly Val 
    2510                 2515                 2520             


Phe Lys  Gly Pro Asp Gly Phe  Glu Tyr Phe Ala Pro  Ala Asn Thr 
    2525                 2530                 2535             


Asp Ala  Asn Asn Ile Glu Gly  Gln Ala Ile Arg Tyr  Gln Asn Arg 
    2540                 2545                 2550             


Phe Leu  Tyr Leu His Asp Asn  Ile Tyr Tyr Phe Gly  Asn Asn Ser 
    2555                 2560                 2565             


Lys Ala  Ala Thr Gly Trp Val  Thr Ile Asp Gly Asn  Arg Tyr Tyr 
    2570                 2575                 2580             


Phe Glu  Pro Asn Thr Ala Met  Gly Ala Asn Gly Tyr  Lys Thr Ile 
    2585                 2590                 2595             


Asp Asn  Lys Asn Phe Tyr Phe  Arg Asn Gly Leu Pro  Gln Ile Gly 
    2600                 2605                 2610             


Val Phe  Lys Gly Ser Asn Gly  Phe Glu Tyr Phe Ala  Pro Ala Asn 
    2615                 2620                 2625             


Thr Asp  Ala Asn Asn Ile Glu  Gly Gln Ala Ile Arg  Tyr Gln Asn 
    2630                 2635                 2640             


Arg Phe  Leu His Leu Leu Gly  Lys Ile Tyr Tyr Phe  Gly Asn Asn 
    2645                 2650                 2655             


Ser Lys  Ala Val Thr Gly Trp  Gln Thr Ile Asn Gly  Lys Val Tyr 
    2660                 2665                 2670             


Tyr Phe  Met Pro Asp Thr Ala  Met Ala Ala Ala Gly  Gly Leu Phe 
    2675                 2680                 2685             


Glu Ile  Asp Gly Val Ile Tyr  Phe Phe Gly Val 
    2690                 2695                 


<210>  6
<211>  2365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe 
1               5                   10                  15      


Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu 
            20                  25                  30          


Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys Leu 
        35                  40                  45              


Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys 
    50                  55                  60                  


Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr 
65                  70                  75                  80  


Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn 
                85                  90                  95      


Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn 
            100                 105                 110         


Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val 
        115                 120                 125             


Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val 
    130                 135                 140                 


Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu 
145                 150                 155                 160 


Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu 
                165                 170                 175     


Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln 
            180                 185                 190         


Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr 
        195                 200                 205             


Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile 
    210                 215                 220                 


Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg 
225                 230                 235                 240 


Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln 
                245                 250                 255     


Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu Arg 
            260                 265                 270         


Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Ala Val Ala Met 
        275                 280                 285             


Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser 
    290                 295                 300                 


Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 


Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met 
                325                 330                 335     


Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys 
            340                 345                 350         


Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser 
        355                 360                 365             


Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln 
    370                 375                 380                 


Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys 
385                 390                 395                 400 


Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala 
                405                 410                 415     


Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp 
            420                 425                 430         


Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu 
        435                 440                 445             


Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr 
    450                 455                 460                 


Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu 
465                 470                 475                 480 


Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp 
                485                 490                 495     


Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu 
            500                 505                 510         


Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala 
        515                 520                 525             


Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu 
    530                 535                 540                 


Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr 
545                 550                 555                 560 


Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr 
                565                 570                 575     


Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu Ala 
            580                 585                 590         


Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln 
        595                 600                 605             


Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp 
    610                 615                 620                 


Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser 
625                 630                 635                 640 


Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp Glu 
                645                 650                 655     


Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr 
            660                 665                 670         


Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys 
        675                 680                 685             


Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile 
    690                 695                 700                 


Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp 
705                 710                 715                 720 


Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val 
                725                 730                 735     


Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu 
            740                 745                 750         


Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile Ile 
        755                 760                 765             


Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu Asn 
    770                 775                 780                 


Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu Leu 
785                 790                 795                 800 


Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu Glu 
                805                 810                 815     


Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile Asp 
            820                 825                 830         


Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr Ser 
        835                 840                 845             


Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser Ile 
    850                 855                 860                 


Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp Ser 
865                 870                 875                 880 


His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe Ser 
                885                 890                 895     


Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu Thr 
            900                 905                 910         


Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu Ile 
        915                 920                 925             


Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu Val 
    930                 935                 940                 


Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn Ala 
945                 950                 955                 960 


Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu Ser 
                965                 970                 975     


Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln Leu 
            980                 985                 990         


Phe Ser Thr Gly Leu Asn Thr Ile  Thr Asp Ala Ala Lys  Val Val Glu 
        995                 1000                 1005             


Leu Val  Ser Thr Ala Leu Asp  Glu Thr Ile Asp Leu  Leu Pro Thr 
    1010                 1015                 1020             


Leu Ser  Glu Gly Leu Pro Ile  Ile Ala Thr Ile Ile  Asp Gly Val 
    1025                 1030                 1035             


Ser Leu  Gly Ala Ala Ile Lys  Glu Leu Ser Glu Thr  Ser Asp Pro 
    1040                 1045                 1050             


Leu Leu  Arg Gln Glu Ile Glu  Ala Lys Ile Gly Ile  Met Ala Val 
    1055                 1060                 1065             


Asn Leu  Thr Thr Ala Thr Thr  Ala Ile Ile Thr Ser  Ser Leu Gly 
    1070                 1075                 1080             


Ile Ala  Ser Gly Phe Ser Ile  Leu Leu Val Pro Leu  Ala Gly Ile 
    1085                 1090                 1095             


Ser Ala  Gly Ile Pro Ser Leu  Val Asn Asn Glu Leu  Val Leu Arg 
    1100                 1105                 1110             


Asp Lys  Ala Thr Lys Val Val  Asp Tyr Phe Lys His  Val Ser Leu 
    1115                 1120                 1125             


Val Glu  Thr Glu Gly Val Phe  Thr Leu Leu Asp Asp  Lys Ile Met 
    1130                 1135                 1140             


Met Pro  Gln Asp Asp Leu Val  Ile Ser Glu Ile Asp  Phe Asn Asn 
    1145                 1150                 1155             


Asn Ser  Ile Val Leu Gly Lys  Cys Glu Ile Trp Arg  Met Glu Gly 
    1160                 1165                 1170             


Gly Ser  Gly His Thr Val Thr  Asp Asp Ile Asp His  Phe Phe Ser 
    1175                 1180                 1185             


Ala Pro  Ser Ile Thr Tyr Arg  Glu Pro His Leu Ser  Ile Tyr Asp 
    1190                 1195                 1200             


Val Leu  Glu Val Gln Lys Glu  Glu Leu Asp Leu Ser  Lys Asp Leu 
    1205                 1210                 1215             


Met Val  Leu Pro Asn Ala Pro  Asn Arg Val Phe Ala  Trp Glu Thr 
    1220                 1225                 1230             


Gly Trp  Thr Pro Gly Leu Arg  Ser Leu Glu Asn Asp  Gly Thr Lys 
    1235                 1240                 1245             


Leu Leu  Asp Arg Ile Arg Asp  Asn Tyr Glu Gly Glu  Phe Tyr Trp 
    1250                 1255                 1260             


Arg Tyr  Phe Ala Phe Ile Ala  Asp Ala Leu Ile Thr  Thr Leu Lys 
    1265                 1270                 1275             


Pro Arg  Tyr Glu Asp Thr Asn  Ile Arg Ile Asn Leu  Asp Ser Asn 
    1280                 1285                 1290             


Thr Arg  Ser Phe Ile Val Pro  Ile Ile Thr Thr Glu  Tyr Ile Arg 
    1295                 1300                 1305             


Glu Lys  Leu Ser Tyr Ser Phe  Tyr Gly Ser Gly Gly  Thr Tyr Ala 
    1310                 1315                 1320             


Leu Ser  Leu Ser Gln Tyr Asn  Met Gly Ile Asn Ile  Glu Leu Ser 
    1325                 1330                 1335             


Glu Ser  Asp Val Trp Ile Ile  Asp Val Asp Asn Val  Val Arg Asp 
    1340                 1345                 1350             


Val Thr  Ile Glu Ser Asp Lys  Ile Lys Lys Gly Asp  Leu Ile Glu 
    1355                 1360                 1365             


Gly Ile  Leu Ser Thr Leu Ser  Ile Glu Glu Asn Lys  Ile Ile Leu 
    1370                 1375                 1380             


Asn Ser  His Glu Ile Asn Phe  Ser Gly Glu Val Asn  Gly Ser Asn 
    1385                 1390                 1395             


Gly Phe  Val Ser Leu Thr Phe  Ser Ile Leu Glu Gly  Ile Asn Ala 
    1400                 1405                 1410             


Ile Ile  Glu Val Asp Leu Leu  Ser Lys Ser Tyr Lys  Leu Leu Ile 
    1415                 1420                 1425             


Ser Gly  Glu Leu Lys Ile Leu  Met Leu Asn Ser Asn  His Ile Gln 
    1430                 1435                 1440             


Gln Lys  Ile Asp Tyr Ile Gly  Phe Asn Ser Glu Leu  Gln Lys Asn 
    1445                 1450                 1455             


Ile Pro  Tyr Ser Phe Val Asp  Ser Glu Gly Lys Glu  Asn Gly Phe 
    1460                 1465                 1470             


Ile Asn  Gly Ser Thr Lys Glu  Gly Leu Phe Val Ser  Glu Leu Pro 
    1475                 1480                 1485             


Asp Val  Val Leu Ile Ser Lys  Val Tyr Met Asp Asp  Ser Lys Pro 
    1490                 1495                 1500             


Ser Phe  Gly Tyr Tyr Ser Asn  Asn Leu Lys Asp Val  Lys Val Ile 
    1505                 1510                 1515             


Thr Lys  Asp Asn Val Asn Ile  Leu Thr Gly Tyr Tyr  Leu Lys Asp 
    1520                 1525                 1530             


Asp Ile  Lys Ile Ser Leu Ser  Leu Thr Leu Gln Asp  Glu Lys Thr 
    1535                 1540                 1545             


Ile Lys  Leu Asn Ser Val His  Leu Asp Glu Ser Gly  Val Ala Glu 
    1550                 1555                 1560             


Ile Leu  Lys Phe Met Asn Arg  Lys Gly Asn Thr Asn  Thr Ser Asp 
    1565                 1570                 1575             


Ser Leu  Met Ser Phe Leu Glu  Ser Met Asn Ile Lys  Ser Ile Phe 
    1580                 1585                 1590             


Val Asn  Phe Leu Gln Ser Asn  Ile Lys Phe Ile Leu  Asp Ala Asn 
    1595                 1600                 1605             


Phe Ile  Ile Ser Gly Thr Thr  Ser Ile Gly Gln Phe  Glu Phe Ile 
    1610                 1615                 1620             


Cys Asp  Glu Asn Asp Asn Ile  Gln Pro Tyr Phe Ile  Lys Phe Asn 
    1625                 1630                 1635             


Thr Leu  Glu Thr Asn Tyr Thr  Leu Tyr Val Gly Asn  Arg Gln Asn 
    1640                 1645                 1650             


Met Ile  Val Glu Pro Asn Tyr  Asp Leu Asp Asp Ser  Gly Asp Ile 
    1655                 1660                 1665             


Ser Ser  Thr Val Ile Asn Phe  Ser Gln Lys Tyr Leu  Tyr Gly Ile 
    1670                 1675                 1680             


Asp Ser  Cys Val Asn Lys Val  Val Ile Ser Pro Asn  Ile Tyr Thr 
    1685                 1690                 1695             


Asp Glu  Ile Asn Ile Thr Pro  Val Tyr Glu Thr Asn  Asn Thr Tyr 
    1700                 1705                 1710             


Pro Glu  Val Ile Val Leu Asp  Ala Asn Tyr Ile Asn  Glu Lys Ile 
    1715                 1720                 1725             


Asn Val  Asn Ile Asn Asp Leu  Ser Ile Arg Tyr Val  Trp Ser Asn 
    1730                 1735                 1740             


Asp Gly  Asn Asp Phe Ile Leu  Met Ser Thr Ser Glu  Glu Asn Lys 
    1745                 1750                 1755             


Val Ser  Gln Val Lys Ile Arg  Phe Val Asn Val Phe  Lys Asp Lys 
    1760                 1765                 1770             


Thr Leu  Ala Asn Lys Leu Ser  Phe Asn Phe Ser Asp  Lys Gln Asp 
    1775                 1780                 1785             


Val Pro  Val Ser Glu Ile Ile  Leu Ser Phe Thr Pro  Ser Tyr Tyr 
    1790                 1795                 1800             


Glu Asp  Gly Leu Ile Gly Tyr  Asp Leu Gly Leu Val  Ser Leu Tyr 
    1805                 1810                 1815             


Asn Glu  Lys Phe Tyr Ile Asn  Asn Phe Gly Met Met  Val Ser Gly 
    1820                 1825                 1830             


Leu Ile  Tyr Ile Asn Asp Ser  Leu Tyr Tyr Phe Lys  Pro Pro Val 
    1835                 1840                 1845             


Asn Asn  Leu Ile Thr Gly Phe  Val Thr Val Gly Asp  Asp Lys Tyr 
    1850                 1855                 1860             


Tyr Phe  Asn Pro Ile Asn Gly  Gly Ala Ala Ser Ile  Gly Glu Thr 
    1865                 1870                 1875             


Ile Ile  Asp Asp Lys Asn Tyr  Tyr Phe Asn Gln Ser  Gly Val Leu 
    1880                 1885                 1890             


Gln Thr  Gly Val Phe Ser Thr  Glu Asp Gly Phe Lys  Tyr Phe Ala 
    1895                 1900                 1905             


Pro Ala  Asn Thr Leu Asp Glu  Asn Leu Glu Gly Glu  Ala Ile Asp 
    1910                 1915                 1920             


Phe Thr  Gly Lys Leu Ile Ile  Asp Glu Asn Ile Tyr  Tyr Phe Asp 
    1925                 1930                 1935             


Asp Asn  Tyr Arg Gly Ala Val  Glu Trp Lys Glu Leu  Asp Gly Glu 
    1940                 1945                 1950             


Met His  Tyr Phe Ser Pro Glu  Thr Gly Lys Ala Phe  Lys Gly Leu 
    1955                 1960                 1965             


Asn Gln  Ile Gly Asp Tyr Lys  Tyr Tyr Phe Asn Ser  Asp Gly Val 
    1970                 1975                 1980             


Met Gln  Lys Gly Phe Val Ser  Ile Asn Asp Asn Lys  His Tyr Phe 
    1985                 1990                 1995             


Asp Asp  Ser Gly Val Met Lys  Val Gly Tyr Thr Glu  Ile Asp Gly 
    2000                 2005                 2010             


Lys His  Phe Tyr Phe Ala Glu  Asn Gly Glu Met Gln  Ile Gly Val 
    2015                 2020                 2025             


Phe Asn  Thr Glu Asp Gly Phe  Lys Tyr Phe Ala His  His Asn Glu 
    2030                 2035                 2040             


Asp Leu  Gly Asn Glu Glu Gly  Glu Glu Ile Ser Tyr  Ser Gly Ile 
    2045                 2050                 2055             


Leu Asn  Phe Asn Asn Lys Ile  Tyr Tyr Phe Asp Asp  Ser Phe Thr 
    2060                 2065                 2070             


Ala Val  Val Gly Trp Lys Asp  Leu Glu Asp Gly Ser  Lys Tyr Tyr 
    2075                 2080                 2085             


Phe Asp  Glu Asp Thr Ala Glu  Ala Tyr Ile Gly Leu  Ser Leu Ile 
    2090                 2095                 2100             


Asn Asp  Gly Gln Tyr Tyr Phe  Asn Asp Asp Gly Ile  Met Gln Val 
    2105                 2110                 2115             


Gly Phe  Val Thr Ile Asn Asp  Lys Val Phe Tyr Phe  Ser Asp Ser 
    2120                 2125                 2130             


Gly Ile  Ile Glu Ser Gly Val  Gln Asn Ile Asp Asp  Asn Tyr Phe 
    2135                 2140                 2145             


Tyr Ile  Asp Asp Asn Gly Ile  Val Gln Ile Gly Val  Phe Asp Thr 
    2150                 2155                 2160             


Ser Asp  Gly Tyr Lys Tyr Phe  Ala Pro Ala Asn Thr  Val Asn Asp 
    2165                 2170                 2175             


Asn Ile  Tyr Gly Gln Ala Val  Glu Tyr Ser Gly Leu  Val Arg Val 
    2180                 2185                 2190             


Gly Glu  Asp Val Tyr Tyr Phe  Gly Glu Thr Tyr Thr  Ile Glu Thr 
    2195                 2200                 2205             


Gly Trp  Ile Tyr Asp Met Glu  Asn Glu Ser Asp Lys  Tyr Tyr Phe 
    2210                 2215                 2220             


Asn Pro  Glu Thr Lys Lys Ala  Cys Lys Gly Ile Asn  Leu Ile Asp 
    2225                 2230                 2235             


Asp Ile  Lys Tyr Tyr Phe Asp  Glu Lys Gly Ile Met  Arg Thr Gly 
    2240                 2245                 2250             


Leu Ile  Ser Phe Glu Asn Asn  Asn Tyr Tyr Phe Asn  Glu Asn Gly 
    2255                 2260                 2265             


Glu Met  Gln Phe Gly Tyr Ile  Asn Ile Glu Asp Lys  Met Phe Tyr 
    2270                 2275                 2280             


Phe Gly  Glu Asp Gly Val Met  Gln Ile Gly Val Phe  Asn Thr Pro 
    2285                 2290                 2295             


Asp Gly  Phe Lys Tyr Phe Ala  His Gln Asn Thr Leu  Asp Glu Asn 
    2300                 2305                 2310             


Phe Glu  Gly Glu Ser Ile Asn  Tyr Thr Gly Trp Leu  Asp Leu Asp 
    2315                 2320                 2325             


Glu Lys  Arg Tyr Tyr Phe Thr  Asp Glu Tyr Ile Ala  Ala Thr Gly 
    2330                 2335                 2340             


Ser Val  Ile Ile Asp Gly Glu  Glu Tyr Tyr Phe Asp  Pro Asp Thr 
    2345                 2350                 2355             


Ala Gln  Leu Val Ile Ser Glu  
    2360                 2365 


<210>  7
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Pro Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Ile Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Met Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 


<210>  8
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8

Met Glu Leu Leu Ile His Arg Ser Ser Ala Ile Phe Leu Thr Leu Ala 
1               5                   10                  15      


Val Asn Ala Leu Tyr Leu Thr Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Arg Gly Tyr Phe Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Thr Lys Cys Asn Gly Thr Asp Thr Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Asn Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Ala Pro 
            100                 105                 110         


Gln Tyr Met Asn Tyr Thr Ile Asn Thr Thr Lys Asn Leu Asn Val Ser 
        115                 120                 125             


Ile Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Asn Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asn Asn Arg Leu Leu Pro Ile Val Asn 
        195                 200                 205             


Gln Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Met Asn Ser Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Leu Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Ser Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Ile Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Ile Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Asp Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Ser Leu Cys Asn Thr 
    370                 375                 380                 


Asp Ile Phe Asn Ser Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Ile Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Leu Glu Gly 
    450                 455                 460                 


Lys Asn Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Tyr Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Arg Ser Asp Glu Leu 
            500                 505                 510         


Leu His Asn Val Asn Thr Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             


Thr Ile Ile Ile Val Ile Ile Val Val Leu Leu Ser Leu Ile Ala Ile 
    530                 535                 540                 


Gly Leu Leu Leu Tyr Cys Lys Ala Lys Asn Thr Pro Val Thr Leu Ser 
545                 550                 555                 560 


Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Lys 
                565                 570                 


<210>  9
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9

Gln Asn Ile Thr Glu Glu Phe Tyr Gln Ser Thr Cys Ser Ala Val Ser 
1               5                   10                  15      


Lys Gly Tyr Leu Ser Ala Leu Arg Thr Gly Trp Tyr Thr Ser Val Ile 
            20                  25                  30          


Thr Ile Glu Leu Ser Asn Ile Lys Glu Asn Lys Cys Asn Gly Thr Asp 
        35                  40                  45              


Ala Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala 
    50                  55                  60                  


Val Thr Glu Leu Gln Leu Leu Met Gln Ser Thr Pro Ala Cys Asn Ser 
65                  70                  75                  80  


Arg Ala Arg Arg 
                


<210>  10
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Phe Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Cys Ala Ser Gly Ile 
1               5                   10                  15      


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
            20                  25                  30          


Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
        35                  40                  45              


Val Ser Val Leu Thr Ile Lys Val Leu Asp Leu Lys Asn Tyr Ile Asp 
    50                  55                  60                  


Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu Glu 
                85                  90                  95      


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val Ser 
            100                 105                 110         


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
        115                 120                 125             


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Ser Asn Val Gln Ile 
    130                 135                 140                 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
145                 150                 155                 160 


Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr Pro 
                165                 170                 175     


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys Glu 
            180                 185                 190         


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
        195                 200                 205             


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys Val 
    210                 215                 220                 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr Leu Pro 
225                 230                 235                 240 


Ser Glu Val Asn Leu Cys Asn Ile Asp Ile Phe Asn Pro Lys Tyr Asp 
                245                 250                 255     


Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile Thr 
            260                 265                 270         


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
        275                 280                 285             


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
    290                 295                 300                 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
305                 310                 315                 320 


Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly Glu 
                325                 330                 335     


Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Ser Glu Phe 
            340                 345                 350         


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
        355                 360                 365             


Phe Ile Arg Lys Ser Asp Glu Leu Leu 
    370                 375         


<210>  11
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Gln Asn Ile Thr Glu Glu Phe Tyr Gln Ser Thr Cys Ser Ala Val Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Ser Ala Leu Arg Thr Gly Trp Tyr Thr Ser Val Ile 
            20                  25                  30          


Thr Ile Glu Leu Ser Asn Ile Lys Glu Thr Lys Cys Asn Gly Thr Asp 
        35                  40                  45              


Thr Lys Val Lys Leu Ile Lys Gln Glu Leu Asp Lys Tyr Lys Asn Ala 
    50                  55                  60                  


Val Thr Glu Leu Gln Leu Leu Met Gln Asn Thr Pro Ala Cys Asn Asn 
65                  70                  75                  80  


Arg Ala Arg Arg 
                


<210>  12
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Phe Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Cys Ala Ser Gly Ile 
1               5                   10                  15      


Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile Lys 
            20                  25                  30          


Asn Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn Gly 
        35                  40                  45              


Val Ser Val Leu Thr Ile Lys Val Leu Asp Leu Lys Asn Tyr Ile Asn 
    50                  55                  60                  


Asn Gln Leu Leu Pro Ile Val Asn Gln Gln Ser Cys Arg Ile Ser Asn 
65                  70                  75                  80  


Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Ser Arg Leu Leu Glu 
                85                  90                  95      


Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Leu Ser 
            100                 105                 110         


Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met 
        115                 120                 125             


Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Ser Asn Val Gln Ile 
    130                 135                 140                 


Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu Glu Val 
145                 150                 155                 160 


Leu Ala Tyr Val Val Gln Leu Pro Ile Tyr Gly Val Ile Asp Thr Pro 
                165                 170                 175     


Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Ile Lys Glu 
            180                 185                 190         


Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys Asp 
        195                 200                 205             


Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Asp Thr Cys Lys Val 
    210                 215                 220                 


Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr Leu Pro 
225                 230                 235                 240 


Ser Glu Val Ser Leu Cys Asn Thr Asp Ile Phe Asn Ser Lys Tyr Asp 
                245                 250                 255     


Cys Lys Ile Met Thr Ser Lys Thr Asp Ile Ser Ser Ser Val Ile Thr 
            260                 265                 270         


Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr Ala 
        275                 280                 285             


Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys Asp 
    290                 295                 300                 


Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr Leu 
305                 310                 315                 320 


Tyr Tyr Val Asn Lys Leu Glu Gly Lys Asn Leu Tyr Val Lys Gly Glu 
                325                 330                 335     


Pro Ile Ile Asn Tyr Tyr Asp Pro Leu Val Phe Pro Ser Ser Glu Phe 
            340                 345                 350         


Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala 
        355                 360                 365             


Phe Ile Arg Arg Ser Asp Glu Leu Leu 
    370                 375         


