                         SEQUENCE LISTING

<110>  Twinpig Biolab, Inc.
 
<120>  PEPTIDES TARGETING MACROPHAGES, AND CONJUGATES, COMPOSITIONS, AND
        USES THEREOF

<130>  3409-0001WO01

<150>  63/185,503
<151>  2021-05-07

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MEL

<400>  1

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MEL826 or Mpep

<400>  2

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  3
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is an amino acid other than valine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is an amino acid other than leucine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is an amino acid other than threonine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is an amino acid other than proline

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is an amino acid other than serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is an amino acid other than lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is an amino acid other than glutamine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is an amino acid other than glutamine

<400>  3

Xaa Xaa Thr Xaa Gly Leu Xaa Ala Leu Ile Xaa Trp Ile Xaa Arg Lys 
1               5                   10                  15      


Arg Xaa Xaa 
            


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is an amino acid other than leucine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is an amino acid other than threonine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is an amino acid other than proline

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is an amino acid other than serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is an amino acid other than lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is an amino acid other than glutamine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is an amino acid other than glutamine

<400>  4

Ala Xaa Thr Xaa Gly Leu Xaa Ala Leu Ile Xaa Trp Ile Xaa Arg Lys 
1               5                   10                  15      


Arg Xaa Xaa 
            


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is an amino acid other than valine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is an amino acid other than threonine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is an amino acid other than proline

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is an amino acid other than serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is an amino acid other than lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is an amino acid other than glutamine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is an amino acid other than glutamine

<400>  5

Xaa Ala Thr Xaa Gly Leu Xaa Ala Leu Ile Xaa Trp Ile Xaa Arg Lys 
1               5                   10                  15      


Arg Xaa Xaa 
            


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is an amino acid other than valine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is an amino acid other than leucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is an amino acid other than proline

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is an amino acid other than serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is an amino acid other than lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is an amino acid other than glutamine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is an amino acid other than glutamine

<400>  6

Xaa Xaa Thr Ala Gly Leu Xaa Ala Leu Ile Xaa Trp Ile Xaa Arg Lys 
1               5                   10                  15      


Arg Xaa Xaa 
            


<210>  7
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is an amino acid other than valine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is an amino acid other than leucine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is an amino acid other than threonine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is an amino acid other than serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is an amino acid other than lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is an amino acid other than glutamine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is an amino acid other than glutamine

<400>  7

Xaa Xaa Thr Xaa Gly Leu Ala Ala Leu Ile Xaa Trp Ile Xaa Arg Lys 
1               5                   10                  15      


Arg Xaa Xaa 
            


<210>  8
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is an amino acid other than valine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is an amino acid other than leucine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is an amino acid other than threonine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is an amino acid other than proline

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is an amino acid other than lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is an amino acid other than glutamine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is an amino acid other than glutamine

<400>  8

Xaa Xaa Thr Xaa Gly Leu Xaa Ala Leu Ile Ala Trp Ile Xaa Arg Lys 
1               5                   10                  15      


Arg Xaa Xaa 
            


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is an amino acid other than valine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is an amino acid other than leucine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is an amino acid other than threonine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is an amino acid other than proline

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is an amino acid other than serine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is an amino acid other than glutamine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is an amino acid other than glutamine

<400>  9

Xaa Xaa Thr Xaa Gly Leu Xaa Ala Leu Ile Xaa Trp Ile Ala Arg Lys 
1               5                   10                  15      


Arg Xaa Xaa 
            


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is an amino acid other than valine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is an amino acid other than leucine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is an amino acid other than threonine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is an amino acid other than proline

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is an amino acid other than serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is an amino acid other than lysine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is an amino acid other than glutamine

<400>  10

Xaa Xaa Thr Xaa Gly Leu Xaa Ala Leu Ile Xaa Trp Ile Xaa Arg Lys 
1               5                   10                  15      


Arg Ala Xaa 
            


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is an amino acid other than valine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is an amino acid other than leucine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is an amino acid other than threonine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is an amino acid other than proline

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is an amino acid other than serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is an amino acid other than lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is an amino acid other than glutamine

<400>  11

Xaa Xaa Thr Xaa Gly Leu Xaa Ala Leu Ile Xaa Trp Ile Xaa Arg Lys 
1               5                   10                  15      


Arg Xaa Ala 
            


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  12

Ala Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  13

Val Ala Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  14

Val Leu Ala Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  15
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  15

Val Leu Thr Ala Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  16

Val Leu Thr Thr Ala Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  17

Val Leu Thr Thr Gly Ala Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  18

Val Leu Thr Thr Gly Leu Ala Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  19

Val Leu Thr Thr Gly Leu Pro Ala Ala Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  20
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  20

Val Leu Thr Thr Gly Leu Pro Ala Leu Ala Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  21

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ala Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  22

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Ala Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  23

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ala Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  24

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Ala Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  25

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Ala Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  26

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Ala 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  27
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  27

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Ala Gln Gln 
            


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  28

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Ala Gln 
            


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  29

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Ala 
            


<210>  30
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  30

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Ala 
            


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  31

Val Leu Ala Ala Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  32

Val Leu Ala Thr Gly Leu Pro Ala Leu Ile Ala Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  33

Val Leu Thr Thr Gly Ala Ala Ala Ala Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Gln Gln 
            


<210>  34
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  34

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys 
1               5                   10                  15      


Arg Ala Ala 
            


<210>  35
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpep

<400>  35

Val Leu Ala Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Ala Ala 
1               5                   10                  15      


Ala Gln Ala 
            


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  36

Gly Gly Gly Gly Ser 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  37

Glu Ala Ala Ala Lys 
1               5   


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  38

Leu Glu Ala Gly Cys Lys Asn Phe Phe Pro Arg Ser Phe Thr Ser Cys 
1               5                   10                  15      


Gly Ser Leu Glu 
            20  


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  39

Cys Arg Arg Arg Arg Arg Arg Glu Ala Glu Ala Cys 
1               5                   10          


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  40

Arg Leu Arg Trp Arg 
1               5   


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  41

Gly Arg Pro Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu Lys 
1               5                   10                  15      


Pro 
    


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  42

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  43

Arg Tyr Ile Arg Ser 
1               5   


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  44

Arg Arg Met Lys Trp Lys Lys 
1               5           


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is 1-4 arginines

<400>  45

Arg Arg Arg Arg Arg Arg Arg Arg Xaa 
1               5                   


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  46

Arg Arg Arg Arg Arg Arg Arg Arg Arg Phe Phe Cys 
1               5                   10          


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  47

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
1               5                   10                  


<210>  48
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Scrambled peptide

<400>  48

Leu Ser Arg Gln Arg Ala Leu Gln Ile Lys Gly Leu Ile Lys Thr Pro 
1               5                   10                  15      


Trp Lys Ile Ala Gly Val Leu Gly Val Thr 
            20                  25      


<210>  49
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAMpep114

<400>  49

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro 
1               5                   10                  


<210>  50
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAMpep120

<400>  50

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile 
            20  


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAMpep820

<400>  51

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile 
1               5                   10              


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAMpep822

<400>  52

Val Leu Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg 
1               5                   10                  15  


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAMpep1026

<400>  53

Thr Thr Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys Arg Gln 
1               5                   10                  15      


Gln 
    


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAMpep1226

<400>  54

Gly Leu Pro Ala Leu Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
1               5                   10                  15  


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAMpep1526

<400>  55

Ala Leu Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
1               5                   10          


