                         SEQUENCE LISTING

<110>  ASTRAZENECA UK LIMITED
       OXFORD UNIVERSITY INNOVATION LIMITED
 
<120>  Compositions and Methods for Inducing an Immune Response

<130>  |P10840WO|

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Coronaviridae

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  30842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChAdOx2: Viral vector based on Chimpanzee adenovirus C68

<400>  2
ccatcttcaa taatatacct caaacttttt gtgcgcgtta atatgcaaat gaggcgtttg       60

aatttgggga ggaagggcgg tgattggtcg agggatgagc gaccgttagg ggcggggcga      120

gtgacgtttt gatgacgtgg ttgcgaggag gagccagttt gcaagttctc gtgggaaaag      180

tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca attttcccgc gctctctgac      240

aggaaatgag gtgtttctgg gcggatgcaa gtgaaaacgg gccattttcg cgcgaaaact      300

gaatgaggaa gtgaaaatct gagtaatttc gcgtttatgg cagggaggag tatttgccga      360

gggccgagta gactttgacc gattacgtgg gggtttcgat taccgtgttt ttcacctaaa      420

tttccgcgta cggtgtcaaa gtccggtgtt tttacgcgat cgctagcgac atcgatcaca      480

agtttgtaca aaaaagctga acgagaaacg taaaatgata taaatatcaa tatattaaat      540

tagattttgc ataaaaaaca gactacataa tactgtaaaa cacaacatat ccagtcacta      600

tggcggccgc cgatttattc aacaaagcca cgttgtgtct caaaatctct gatgttacat      660

tgcacaagat aaaaatatat catcatgaac aataaaactg tctgcttaca taaacagtaa      720

tacaaggggt gttatgagcc atattcaacg ggaaacgtct tgctcgaggc cgcgattaaa      780

ttccaacatg gatgctgatt tatatgggta taaatgggct cgtgataatg tcgggcaatc      840

aggtgcgaca atctatcgat tgtatgggaa gcccgatgcg ccagagttgt ttctgaaaca      900

tggcaaaggt agcgttgcca atgatgttac agatgagatg gtcagactaa actggctgac      960

ggaatttatg cctcttccga ccatcaagca ttttatccgt actcctgatg atgcatggtt     1020

actcaccact gcgatccccg ggaaaacagc attccaggta ttagaagaat atcctgattc     1080

aggtgaaaat attgttgatg cgctggcagt gttcctgcgc cggttgcatt cgattcctgt     1140

ttgtaattgt ccttttaaca gcgatcgcgt atttcgtctc gctcaggcgc aatcacgaat     1200

gaataacggt ttggttgatg cgagtgattt tgatgacgag cgtaatggct ggcctgttga     1260

acaagtctgg aaagaaatgc ataagctttt gccattctca ccggattcag tcgtcactca     1320

tggtgatttc tcacttgata accttatttt tgacgagggg aaattaatag gttgtattga     1380

tgttggacga gtcggaatcg cagaccgata ccaggatctt gccatcctat ggaactgcct     1440

cggtgagttt tctccttcat tacagaaacg gctttttcaa aaatatggta ttgataatcc     1500

tgatatgaat aaattgcagt ttcatttgat gctcgatgag tttttctaat cagaattggt     1560

taattggttg taacactggc acgcgtggat ccggcttact aaaagccaga taacagtatg     1620

cgtatttgcg cgctgatttt tgcggtataa gaatatatac tgatatgtat acccgaagta     1680

tgtcaaaaag aggtatgcta tgaagcagcg tattacagtg acagttgaca gcgacagcta     1740

tcagttgctc aaggcatata tgatgtcaat atctccggtc tggtaagcac aaccatgcag     1800

aatgaagccc gtcgtctgcg tgccgaacgc tggaaagcgg aaaatcagga agggatggct     1860

gaggtcgccc ggtttattga aatgaacggc tcttttgctg acgagaacag gggctggtga     1920

aatgcagttt aaggtttaca cctataaaag agagagccgt tatcgtctgt ttgtggatgt     1980

acagagtgat attattgaca cgcccgggcg acggatggtg atccccctgg ccagtgcacg     2040

tctgctgtca gataaagtct cccgtgaact ttacccggtg gtgcatatcg gggatgaaag     2100

ctggcgcatg atgaccaccg atatggccag tgtgccggtc tccgttatcg gggaagaagt     2160

ggctgatctc agccaccgcg aaaatgacat caaaaacgcc attaacctga tgttctgggg     2220

aatataaatg tcaggctccc ttatacacag ccagtctgca ggtcgaccat agtgactgga     2280

tatgttgtgt tttacagtat tatgtagtct gttttttatg caaaatctaa tttaatatat     2340

tgatatttat atcattttac gtttctcgtt cagctttctt gtacaaagtg gtgatcgatt     2400

cgacagatcg cgatcgcaag tgagtagtgt tctggggcgg gggaggacct gcatgagggc     2460

cagaataact gaaatctgtg cttttctgtg tgttgcagca gcatgagcgg aagcggctcc     2520

tttgagggag gggtattcag cccttatctg acggggcgtc tcccctcctg ggcgggagtg     2580

cgtcagaatg tgatgggatc cacggtggac ggccggcccg tgcagcccgc gaactcttca     2640

accctgacct atgcaaccct gagctcttcg tcgttggacg cagctgccgc cgcagctgct     2700

gcatctgccg ccagcgccgt gcgcggaatg gccatgggcg ccggctacta cggcactctg     2760

gtggccaact cgagttccac caataatccc gccagcctga acgaggagaa gctgttgctg     2820

ctgatggccc agctcgaggc cttgacccag cgcctgggcg agctgaccca gcaggtggct     2880

cagctgcagg agcagacgcg ggccgcggtt gccacggtga aatccaaata aaaaatgaat     2940

caataaataa acggagacgg ttgttgattt taacacagag tctgaatctt tatttgattt     3000

ttcgcgcgcg gtaggccctg gaccaccggt ctcgatcatt gagcacccgg tggatctttt     3060

ccaggacccg gtagaggtgg gcttggatgt tgaggtacat gggcatgagc ccgtcccggg     3120

ggtggaggta gctccattgc agggcctcgt gctcgggggt ggtgttgtaa atcacccagt     3180

catagcaggg gcgcagggca tggtgttgca caatatcttt gaggaggaga ctgatggcca     3240

cgggcagccc tttggtgtag gtgtttacaa atctgttgag ctgggaggga tgcatgcggg     3300

gggagatgag gtgcatcttg gcctggatct tgagattggc gatgttaccg cccagatccc     3360

gcctggggtt catgttgtgc aggaccacca gcacggtgta tccggtgcac ttggggaatt     3420

tatcatgcaa cttggaaggg aaggcgtgaa agaatttggc gacgcctttg tgcccgccca     3480

ggttttccat gcactcatcc atgatgatgg cgatgggccc gtgggcggcg gcctgggcaa     3540

agacgtttcg ggggtcggac acatcatagt tgtggtcctg ggtgaggtca tcataggcca     3600

ttttaatgaa tttggggcgg agggtgccgg actgggggac aaaggtaccc tcgatcccgg     3660

gggcgtagtt cccctcacag atctgcatct cccaggcttt gagctcggag ggggggatca     3720

tgtccacctg cggggcgata aagaacacgg tttccggggc gggggagatg agctgggccg     3780

aaagcaagtt ccggagcagc tgggacttgc cgcagccggt ggggccgtag atgaccccga     3840

tgaccggctg caggtggtag ttgagggaga gacagctgcc gtcctcccgg aggagggggg     3900

ccacctcgtt catcatctcg cgcacgtgca tgttctcgcg caccagttcc gccaggaggc     3960

gctctccccc cagggatagg agctcctgga gcgaggcgaa gtttttcagc ggcttgagtc     4020

cgtcggccat gggcattttg gagagggttt gttgcaagag ttccaggcgg tcccagagct     4080

cggtgatgtg ctctacggca tctcgatcca gcagacctcc tcgtttcgcg ggttgggacg     4140

gctgcgggag tagggcacca gacgatgggc gtccagcgca gccagggtcc ggtccttcca     4200

gggtcgcagc gtccgcgtca gggtggtctc cgtcacggtg aaggggtgcg cgccgggctg     4260

ggcgcttgcg agggtgcgct tcaggctcat ccggctggtc gaaaaccgct cccgatcggc     4320

gccctgcgcg tcggccaggt agcaattgac catgagttcg tagttgagcg cctcggccgc     4380

gtggcctttg gcgcggagct tacctttgga agtctgcccg caggcgggac agaggaggga     4440

cttgagggcg tagagcttgg gggcgaggaa gacggactcg ggggcgtagg cgtccgcgcc     4500

gcagtgggcg cagacggtct cgcactccac gagccaggtg aggtcgggct ggtcggggtc     4560

aaaaaccagt ttcccgccgt tctttttgat gcgtttctta cctttggtct ccatgagctc     4620

gtgtccccgc tgggtgacaa agaggctgtc cgtgtccccg tagaccgact ttatgggccg     4680

gtcctcgagc ggtgtgccgc ggtcctcctc gtagaggaac cccgcccact ccgagacgaa     4740

agcccgggtc caggccagca cgaaggaggc cacgtgggac gggtagcggt cgttgtccac     4800

cagcgggtcc accttttcca gggtatgcaa acacatgtcc ccctcgtcca catccaggaa     4860

ggtgattggc ttgtaagtgt aggccacgtg accgggggtc ccggccgggg gggtataaaa     4920

gggtgcgggt ccctgctcgt cctcactgtc ttccggatcg ctgtccagga gcgccagctg     4980

ttggggtagg tattccctct cgaaggcggg catgacctcg gcactcaggt tgtcagtttc     5040

tagaaacgag gaggatttga tattgacggt gccggcggag atgcctttca agagcccctc     5100

gtccatctgg tcagaaaaga cgatcttttt gttgtcgagc ttggtggcga aggagccgta     5160

gagggcgttg gagaggagct tggcgatgga gcgcatggtc tggttttttt ccttgtcggc     5220

gcgctccttg gcggcgatgt tgagctgcac gtactcgcgc gccacgcact tccattcggg     5280

gaagacggtg gtcagctcgt cgggcacgat tctgacctgc cagccccgat tatgcagggt     5340

gatgaggtcc acactggtgg ccacctcgcc gcgcaggggc tcattagtcc agcagaggcg     5400

tccgcccttg cgcgagcaga aggggggcag ggggtccagc atgacctcgt cgggggggtc     5460

ggcatcgatg gtgaagatgc cgggcaggag gtcggggtca aagtagctga tggaagtggc     5520

cagatcgtcc agggcagctt gccattcgcg cacggccagc gcgcgctcgt agggactgag     5580

gggcgtgccc cagggcatgg gatgggtaag cgcggaggcg tacatgccgc agatgtcgta     5640

gacgtagagg ggctcctcga ggatgccgat gtaggtgggg tagcagcgcc ccccgcggat     5700

gctggcgcgc acgtagtcat acagctcgtg cgagggggcg aggagccccg ggcccaggtt     5760

ggtgcgactg ggcttttcgg cgcggtagac gatctggcgg aaaatggcat gcgagttgga     5820

ggagatggtg ggcctttgga agatgttgaa gtgggcgtgg ggcagtccga ccgagtcgcg     5880

gatgaagtgg gcgtaggagt cttgcagctt ggcgacgagc tcggcggtga ctaggacgtc     5940

cagagcgcag tagtcgaggg tctcctggat gatgtcatac ttgagctgtc ccttttgttt     6000

ccacagctcg cggttgagaa ggaactcttc gcggtccttc cagtactctt cgagggggaa     6060

cccgtcctga tctgcacggt aagagcctag catgtagaac tggttgacgg ccttgtaggc     6120

gcagcagccc ttctccacgg ggagggcgta ggcctgggcg gccttgcgca gggaggtgtg     6180

cgtgagggcg aaagtgtccc tgaccatgac cttgaggaac tggtgcttga agtcgatatc     6240

gtcgcagccc ccctgctccc agagctggaa gtccgtgcgc ttcttgtagg cggggttggg     6300

caaagcgaaa gtaacatcgt tgaagaggat cttgcccgcg cggggcataa agttgcgagt     6360

gatgcggaaa ggttggggca cctcggcccg gttgttgatg acctgggcgg cgagcacgat     6420

ctcgtcgaag ccgttgatgt tgtggcccac gatgtagagt tccacgaatc gcggacggcc     6480

cttgacgtgg ggcagtttct tgagctcctc gtaggtgagc tcgtcggggt cgctgagccc     6540

gtgctgctcg agcgcccagt cggcgagatg ggggttggcg cggaggaagg aagtccagag     6600

atccacggcc agggcggttt gcagacggtc ccggtactga cggaactgct gcccgacggc     6660

cattttttcg ggggtgacgc agtagaaggt gcgggggtcc ccgtgccagc gatcccattt     6720

gagctggagg gcgagatcga gggcgagctc gacgagccgg tcgtccccgg agagtttcat     6780

gaccagcatg aaggggacga gctgcttgcc gaaggacccc atccaggtgt aggtttccac     6840

atcgtaggtg aggaagagcc tttcggtgcg aggatgcgag ccgatgggga agaactggat     6900

ctcctgccac caattggagg aatggctgtt gatgtgatgg aagtagaaat gccgacggcg     6960

cgccgaacac tcgtgcttgt gtttatacaa gcggccacag tgctcgcaac gctgcacggg     7020

atgcacgtgc tgcacgagct gtacctgagt tcctttgacg aggaatttca gtgggaagtg     7080

gagtcgtggc gcctgcatct cgtgctgtac tacgtcgtgg tggtcggcct ggccctcttc     7140

tgcctcgatg gtggtcatgc tgacgagccc gcgcgggagg caggtccaga cctcggcgcg     7200

agcgggtcgg agagcgagga cgagggcgcg caggccggag ctgtccaggg tcctgagacg     7260

ctgcggagtc aggtcagtgg gcagcggcgg cgcgcggttg acttgcagga gtttttccag     7320

ggcgcgcggg aggtccagat ggtacttgat ctccaccgcg ccattggtgg cgacgtcgat     7380

ggcttgcagg gtcccgtgcc cctggggtgt gaccaccgtc ccccgtttct tcttgggcgg     7440

ctggggcgac gggggcggtg cctcttccat ggttagaagc ggcggcgagg acgcgcgccg     7500

ggcggcaggg gcggctcggg gcccggaggc aggggcggca ggggcacgtc ggcgccgcgc     7560

gcgggtaggt tctggtactg cgcccggaga agactggcgt gagcgacgac gcgacggttg     7620

acgtcctgga tctgacgcct ctgggtgaag gccacgggac ccgtgagttt gaacctgaaa     7680

gagagttcga cagaatcaat ctcggtatcg ttgacggcgg cctgccgcag gatctcttgc     7740

acgtcgcccg agttgtcctg gtaggcgatc tcggtcatga actgctcgat ctcctcctct     7800

tgaaggtctc cgcggccggc gcgctccacg gtggccgcga ggtcgttgga gatgcggccc     7860

atgagctgcg agaaggcgtt catgcccgcc tcgttccaga cgcggctgta gaccacgacg     7920

ccctcgggat cgccggcgcg catgaccacc tgggcgaggt tgagctccac gtggcgcgtg     7980

aagaccgcgt agttgcagag gcgctggtag aggtagttga gcgtggtggc gatgtgctcg     8040

gtgacgaaga aatacatgat ccagcggcgg agcggcatct cgctgacgtc gcccagcgcc     8100

tccaaacgtt ccatggcctc gtaaaagtcc acggcgaagt tgaaaaactg ggagttgcgc     8160

gccgagacgg tcaactcctc ctccagaaga cggatgagct cggcgatggt ggcgcgcacc     8220

tcgcgctcga aggcccccgg gagttcctcc acttcctctt cttcctcctc cactaacatc     8280

tcttctactt cctcctcagg cggcagtggt ggcgggggag ggggcctgcg tcgccggcgg     8340

cgcacgggca gacggtcgat gaagcgctcg atggtctcgc cgcgccggcg tcgcatggtc     8400

tcggtgacgg cgcgcccgtc ctcgcggggc cgcagcgtga agacgccgcc gcgcatctcc     8460

aggtggccgg gggggtcccc gttgggcagg gagagggcgc tgacgatgca tcttatcaat     8520

tgccccgtag ggactccgcg caaggacctg agcgtctcga gatccacggg atctgaaaac     8580

cgctgaacga aggcttcgag ccagtcgcag tcgcaaggta ggctgagcac ggtttcttct     8640

ggcgggtcat gttggttggg agcggggcgg gcgatgctgc tggtgatgaa gttgaaatag     8700

gcggttctga gacggcggat ggtggcgagg agcaccaggt ctttgggccc ggcttgctgg     8760

atgcgcagac ggtcggccat gccccaggcg tggtcctgac acctggccag gtccttgtag     8820

tagtcctgca tgagccgctc cacgggcacc tcctcctcgc ccgcgcggcc gtgcatgcgc     8880

gtgagcccga agccgcgctg gggctggacg agcgccaggt cggcgacgac gcgctcggcg     8940

aggatggctt gctggatctg ggtgagggtg gtctggaagt catcaaagtc gacgaagcgg     9000

tggtaggctc cggtgttgat ggtgtaggag cagttggcca tgacggacca gttgacggtc     9060

tggtggcccg gacgcacgag ctcgtggtac ttgaggcgcg agtaggcgcg cgtgtcgaag     9120

atgtagtcgt tgcaggtgcg caccaggtac tggtagccga tgaggaagtg cggcggcggc     9180

tggcggtaga gcggccatcg ctcggtggcg ggggcgccgg gcgcgaggtc ctcgagcatg     9240

gtgcggtggt agccgtagat gtacctggac atccaggtga tgccggcggc ggtggtggag     9300

gcgcgcggga actcgcggac gcggttccag atgttgcgca gcggcaggaa gtagttcatg     9360

gtgggcacgg tctggcccgt gaggcgcgcg cagtcgtgga tgctctatac gggcaaaaac     9420

gaaagcggtc agcggctcga ctccgtggcc tggaggctaa gcgaacgggt tgggctgcgc     9480

gtgtaccccg gttcgaatct cgaatcaggc tggagccgca gctaacgtgg tattggcact     9540

cccgtctcga cccaagcctg caccaaccct ccaggatacg gaggcgggtc gttttgcaac     9600

ttttttttgg aggccggatg agactagtaa gcgcggaaag cggccgaccg cgatggctcg     9660

ctgccgtagt ctggagaaga atcgccaggg ttgcgttgcg gtgtgccccg gttcgaggcc     9720

ggccggattc cgcggctaac gagggcgtgg ctgccccgtc gtttccaaga ccccatagcc     9780

agccgacttc tccagttacg gagcgagccc ctcttttgtt ttgtttgttt ttgccagatg     9840

catcccgtac tgcggcagat gcgcccccac caccctccac cgcaacaaca gccccctcca     9900

cagccggcgc ttctgccccc gccccagcag caacttccag ccacgaccgc cgcggccgcc     9960

gtgagcgggg ctggacagag ttatgatcac cagctggcct tggaagaggg cgaggggctg    10020

gcgcgcctgg gggcgtcgtc gccggagcgg cacccgcgcg tgcagatgaa aagggacgct    10080

cgcgaggcct acgtgcccaa gcagaacctg ttcagagaca ggagcggcga ggagcccgag    10140

gagatgcgcg cggcccggtt ccacgcgggg cgggagctgc ggcgcggcct ggaccgaaag    10200

agggtgctga gggacgagga tttcgaggcg gacgagctga cggggatcag ccccgcgcgc    10260

gcgcacgtgg ccgcggccaa cctggtcacg gcgtacgagc agaccgtgaa ggaggagagc    10320

aacttccaaa aatccttcaa caaccacgtg cgcaccctga tcgcgcgcga ggaggtgacc    10380

ctgggcctga tgcacctgtg ggacctgctg gaggccatcg tgcagaaccc caccagcaag    10440

ccgctgacgg cgcagctgtt cctggtggtg cagcatagtc gggacaacga agcgttcagg    10500

gaggcgctgc tgaatatcac cgagcccgag ggccgctggc tcctggacct ggtgaacatt    10560

ctgcagagca tcgtggtgca ggagcgcggg ctgccgctgt ccgagaagct ggcggccatc    10620

aacttctcgg tgctgagttt gggcaagtac tacgctagga agatctacaa gaccccgtac    10680

gtgcccatag acaaggaggt gaagatcgac gggttttaca tgcgcatgac cctgaaagtg    10740

ctgaccctga gcgacgatct gggggtgtac cgcaacgaca ggatgcaccg tgcggtgagc    10800

gccagcaggc ggcgcgagct gagcgaccag gagctgatgc atagtctgca gcgggccctg    10860

accggggccg ggaccgaggg ggagagctac tttgacatgg gcgcggacct gcactggcag    10920

cccagccgcc gggccttgga ggcggcggca ggaccctacg tagaagaggt ggacgatgag    10980

gtggacgagg agggcgagta cctggaagac tgatggcgcg accgtatttt tgctagatgc    11040

aacaacaaca gccacctcct gatcccgcga tgcgggcggc gctgcagagc cagccgtccg    11100

gcattaactc ctcggacgat tggacccagg ccatgcaacg catcatggcg ctgacgaccc    11160

gcaaccccga agcctttaga cagcagcccc aggccaaccg gctctcggcc atcctggagg    11220

ccgtggtgcc ctcgcgctcc aaccccacgc acgagaaggt cctggccatc gtgaacgcgc    11280

tggtggagaa caaggccatc cgcggcgacg aggccggcct ggtgtacaac gcgctgctgg    11340

agcgcgtggc ccgctacaac agcaccaacg tgcagaccaa cctggaccgc atggtgaccg    11400

acgtgcgcga ggccgtggcc cagcgcgagc ggttccaccg cgagtccaac ctgggatcca    11460

tggtggcgct gaacgccttc ctcagcaccc agcccgccaa cgtgccccgg ggccaggagg    11520

actacaccaa cttcatcagc gccctgcgcc tgatggtgac cgaggtgccc cagagcgagg    11580

tgtaccagtc cgggccggac tacttcttcc agaccagtcg ccagggcttg cagaccgtga    11640

acctgagcca ggctttcaag aacttgcagg gcctgtgggg cgtgcaggcc ccggtcgggg    11700

accgcgcgac ggtgtcgagc ctgctgacgc cgaactcgcg cctgctgctg ctgctggtgg    11760

cccccttcac ggacagcggc agcatcaacc gcaactcgta cctgggctac ctgattaacc    11820

tgtaccgcga ggccatcggc caggcgcacg tggacgagca gacctaccag gagatcaccc    11880

acgtgagccg cgccctgggc caggacgacc cgggcaacct ggaagccacc ctgaactttt    11940

tgctgaccaa ccggtcgcag aagatcccgc cccagtacgc gctcagcacc gaggaggagc    12000

gcatcctgcg ttacgtgcag cagagcgtgg gcctgttcct gatgcaggag ggggccaccc    12060

ccagcgccgc gctcgacatg accgcgcgca acatggagcc cagcatgtac gccagcaacc    12120

gcccgttcat caataaactg atggactact tgcatcgggc ggccgccatg aactctgact    12180

atttcaccaa cgccatcctg aatccccact ggctcccgcc gccggggttc tacacgggcg    12240

agtacgacat gcccgacccc aatgacgggt tcctgtggga cgatgtggac agcagcgtgt    12300

tctccccccg accgggtgct aacgagcgcc ccttgtggaa gaaggaaggc agcgaccgac    12360

gcccgtcctc ggcgctgtcc ggccgcgagg gtgctgccgc ggcggtgccc gaggccgcca    12420

gtcctttccc gagcttgccc ttctcgctga acagtatccg cagcagcgag ctgggcagga    12480

tcacgcgccc gcgcttgctg ggcgaagagg agtacttgaa tgactcgctg ttgagacccg    12540

agcgggagaa gaacttcccc aataacggga tagaaagcct ggtggacaag atgagccgct    12600

ggaagacgta tgcgcaggag cacagggacg atccccgggc gtcgcagggg gccacgagcc    12660

ggggcagcgc cgcccgtaaa cgccggtggc acgacaggca gcggggacag atgtgggacg    12720

atgaggactc cgccgacgac agcagcgtgt tggacttggg tgggagtggt aacccgttcg    12780

ctcacctgcg cccccgtatc gggcgcatga tgtaagagaa accgaaaata aatgatactc    12840

accaaggcca tggcgaccag cgtgcgttcg tttcttctct gttgttgttg tatctagtat    12900

gatgaggcgt gcgtacccgg agggtcctcc tccctcgtac gagagcgtga tgcagcaggc    12960

gatggcggcg gcggcgatgc agcccccgct ggaggctcct tacgtgcccc cgcggtacct    13020

ggcgcctacg gaggggcgga acagcattcg ttactcggag ctggcaccct tgtacgatac    13080

cacccggttg tacctggtgg acaacaagtc ggcggacatc gcctcgctga actaccagaa    13140

cgaccacagc aacttcctga ccaccgtggt gcagaacaat gacttcaccc ccacggaggc    13200

cagcacccag accatcaact ttgacgagcg ctcgcggtgg ggcggccagc tgaaaaccat    13260

catgcacacc aacatgccca acgtgaacga gttcatgtac agcaacaagt tcaaggcgcg    13320

ggtgatggtc tcccgcaaga cccccaatgg ggtgacagtg acagaggatt atgatggtag    13380

tcaggatgag ctgaagtatg aatgggtgga atttgagctg cccgaaggca acttctcggt    13440

gaccatgacc atcgacctga tgaacaacgc catcatcgac aattacttgg cggtggggcg    13500

gcagaacggg gtgctggaga gcgacatcgg cgtgaagttc gacactagga acttcaggct    13560

gggctgggac cccgtgaccg agctggtcat gcccggggtg tacaccaacg aggctttcca    13620

tcccgatatt gtcttgctgc ccggctgcgg ggtggacttc accgagagcc gcctcagcaa    13680

cctgctgggc attcgcaaga ggcagccctt ccaggaaggc ttccagatca tgtacgagga    13740

tctggagggg ggcaacatcc ccgcgctcct ggatgtcgac gcctatgaga aaagcaagga    13800

ggatgcagca gctgaagcaa ctgcagccgt agctaccgcc tctaccgagg tcaggggcga    13860

taattttgca agcgccgcag cagtggcagc ggccgaggcg gctgaaaccg aaagtaagat    13920

agtcattcag ccggtggaga aggatagcaa gaacaggagc tacaacgtac taccggacaa    13980

gataaacacc gcctaccgca gctggtacct agcctacaac tatggcgacc ccgagaaggg    14040

cgtgcgctcc tggacgctgc tcaccacctc ggacgtcacc tgcggcgtgg agcaagtcta    14100

ctggtcgctg cccgacatga tgcaagaccc ggtcaccttc cgctccacgc gtcaagttag    14160

caactacccg gtggtgggcg ccgagctcct gcccgtctac tccaagagct tcttcaacga    14220

gcaggccgtc tactcgcagc agctgcgcgc cttcacctcg cttacgcacg tcttcaaccg    14280

cttccccgag aaccagatcc tcgtccgccc gcccgcgccc accattacca ccgtcagtga    14340

aaacgttcct gctctcacag atcacgggac cctgccgctg cgcagcagta tccggggagt    14400

ccagcgcgtg accgttactg acgccagacg ccgcacctgc ccctacgtct acaaggccct    14460

gggcatagtc gcgccgcgcg tcctctcgag ccgcaccttc taaatgtcca ttctcatctc    14520

gcccagtaat aacaccggtt ggggcctgcg cgcgcccagc aagatgtacg gaggcgctcg    14580

ccaacgctcc acgcaacacc ccgtgcgcgt gcgcgggcac ttccgcgctc cctggggcgc    14640

cctcaagggc cgcgtgcggt cgcgcaccac cgtcgacgac gtgatcgacc aggtggtggc    14700

cgacgcgcgc aactacaccc ccgccgccgc gcccgtctcc accgtggacg ccgtcatcga    14760

cagcgtggtg gcggacgcgc gccggtacgc ccgcgccaag agccggcggc ggcgcatcgc    14820

ccggcggcac cggagcaccc ccgccatgcg cgcggcgcga gccttgctgc gcagggccag    14880

gcgcacggga cgcagggcca tgctcagggc ggccagacgc gcggcttcag gcgccagcgc    14940

cggcaggacc cggagacgcg cggccacggc ggcggcagcg gccatcgcca gcatgtcccg    15000

cccgcggcga gggaacgtgt actgggtgcg cgacgccgcc accggtgtgc gcgtgcccgt    15060

gcgcacccgc ccccctcgca cttgaagatg ttcacttcgc gatgttgatg tgtcccagcg    15120

gcgaggagga tgtccaagcg caaattcaag gaagagatgc tccaggtcat cgcgcctgag    15180

atctacggcc ctgcggtggt gaaggaggaa agaaagcccc gcaaaatcaa gcgggtcaaa    15240

aaggacaaaa aggaagaaga aagtgatgtg gacggattgg tggagtttgt gcgcgagttc    15300

gccccccggc ggcgcgtgca gtggcgcggg cggaaggtgc aaccggtgct gagacccggc    15360

accaccgtgg tcttcacgcc cggcgagcgc tccggcaccg cttccaagcg ctcctacgac    15420

gaggtgtacg gggatgatga tattctggag caggcggccg agcgcctggg cgagtttgct    15480

tacggcaagc gcagccgttc cgcaccgaag gaagaggcgg tgtccatccc gctggaccac    15540

ggcaacccca cgccgagcct caagcccgtg accttgcagc aggtgctgcc gaccgcggcg    15600

ccgcgccggg ggttcaagcg cgagggcgag gatctgtacc ccaccatgca gctgatggtg    15660

cccaagcgcc agaagctgga agacgtgctg gagaccatga aggtggaccc ggacgtgcag    15720

cccgaggtca aggtgcggcc catcaagcag gtggccccgg gcctgggcgt gcagaccgtg    15780

gacatcaaga ttcccacgga gcccatggaa acgcagaccg agcccatgat caagcccagc    15840

accagcacca tggaggtgca gacggatccc tggatgccat cggctcctag tcgaagaccc    15900

cggcgcaagt acggcgcggc cagcctgctg atgcccaact acgcgctgca tccttccatc    15960

atccccacgc cgggctaccg cggcacgcgc ttctaccgcg gtcataccag cagccgccgc    16020

cgcaagacca ccactcgccg ccgccgtcgc cgcaccgccg ctgcaaccac ccctgccgcc    16080

ctggtgcgga gagtgtaccg ccgcggccgc gcacctctga ccctgccgcg cgcgcgctac    16140

cacccgagca tcgccattta aactttcgcc agctttgcag atcaatggcc ctcacatgcc    16200

gccttcgcgt tcccattacg ggctaccgag gaagaaaacc gcgccgtaga aggctggcgg    16260

ggaacgggat gcgtcgccac caccaccggc ggcggcgcgc catcagcaag cggttggggg    16320

gaggcttcct gcccgcgctg atccccatca tcgccgcggc gatcggggcg atccccggca    16380

ttgcttccgt ggcggtgcag gcctctcagc gccactgaga cacacttgga aacatcttgt    16440

aataaaccca tggactctga cgctcctggt cctgtgatgt gttttcgtag acagatggaa    16500

gacatcaatt tttcgtccct ggctccgcga cacggcacgc ggccgttcat gggcacctgg    16560

agcgacatcg gcaccagcca actgaacggg ggcgccttca attggagcag tctctggagc    16620

gggcttaaga atttcgggtc cacgcttaaa acctatggca gcaaggcgtg gaacagcacc    16680

acagggcagg cgctgaggga taagctgaaa gagcagaact tccagcagaa ggtggtcgat    16740

gggctcgcct cgggcatcaa cggggtggtg gacctggcca accaggccgt gcagcggcag    16800

atcaacagcc gcctggaccc ggtgccgccc gccggctccg tggagatgcc gcaggtggag    16860

gaggagctgc ctcccctgga caagcggggc gagaagcgac cccgccccga tgcggaggag    16920

acgctgctga cgcacacgga cgagccgccc ccgtacgagg aggcggtgaa actgggtctg    16980

cccaccacgc ggcccatcgc gcccctggcc accggggtgc tgaaacccga aaagcccgcg    17040

accctggact tgcctcctcc ccagccttcc cgcccctcta cagtggctaa gcccctgccg    17100

ccggtggccg tggcccgcgc gcgacccggg ggcaccgccc gccctcatgc gaactggcag    17160

agcactctga acagcatcgt gggtctggga gtgcagagtg tgaagcgccg ccgctgctat    17220

taaacctacc gtagcgctta acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc    17280

cgctgtccac cagaaggagg agtgaagagg cgcgtcgccg agttgcaaga tggccacccc    17340

atcgatgctg ccccagtggg cgtacatgca catcgccgga caggacgctt cggagtacct    17400

gagtccgggt ctggtgcagt ttgcccgcgc cacagacacc tacttcagtc tggggaacaa    17460

gtttaggaac cccacggtgg cgcccacgca cgatgtgacc accgaccgca gccagcggct    17520

gacgctgcgc ttcgtgcccg tggaccgcga ggacaacacc tactcgtaca aagtgcgcta    17580

cacgctggcc gtgggcgaca accgcgtgct ggacatggcc agcacctact ttgacatccg    17640

cggcgtgctg gatcggggcc ctagcttcaa accctactcc ggcaccgcct acaacagtct    17700

ggcccccaag ggagcaccca acacttgtca gtggacatat aaagccgatg gtgaaactgc    17760

cacagaaaaa acctatacat atggaaatgc acccgtgcag ggcattaaca tcacaaaaga    17820

tggtattcaa cttggaactg acaccgatga tcagccaatc tacgcagata aaacctatca    17880

gcctgaacct caagtgggtg atgctgaatg gcatgacatc actggtactg atgaaaagta    17940

tggaggcaga gctcttaagc ctgataccaa aatgaagcct tgttatggtt cttttgccaa    18000

gcctactaat aaagaaggag gtcaggcaaa tgtgaaaaca ggaacaggca ctactaaaga    18060

atatgacata gacatggctt tctttgacaa cagaagtgcg gctgctgctg gcctagctcc    18120

agaaattgtt ttgtatactg aaaatgtgga tttggaaact ccagataccc atattgtata    18180

caaagcaggc acagatgaca gcagctcttc tattaatttg ggtcagcaag ccatgcccaa    18240

cagacctaac tacattggtt tcagagacaa ctttatcggg ctcatgtact acaacagcac    18300

tggcaatatg ggggtgctgg ccggtcaggc ttctcagctg aatgctgtgg ttgacttgca    18360

agacagaaac accgagctgt cctaccagct cttgcttgac tctctgggtg acagaacccg    18420

gtatttcagt atgtggaatc aggcggtgga cagctatgat cctgatgtgc gcattattga    18480

aaatcatggt gtggaggatg aacttcccaa ctattgtttc cctctggatg ctgttggcag    18540

aacagatact tatcagggaa ttaaggctaa tggaactgat caaaccacat ggaccaaaga    18600

tgacagtgtc aatgatgcta atgagatagg caagggtaat ccattcgcca tggaaatcaa    18660

catccaagcc aacctgtgga ggaacttcct ctacgccaac gtggccctgt acctgcccga    18720

ctcttacaag tacacgccgg ccaatgttac cctgcccacc aacaccaaca cctacgatta    18780

catgaacggc cgggtggtgg cgccctcgct ggtggactcc tacatcaaca tcggggcgcg    18840

ctggtcgctg gatcccatgg acaacgtgaa ccccttcaac caccaccgca atgcggggct    18900

gcgctaccgc tccatgctcc tgggcaacgg gcgctacgtg cccttccaca tccaggtgcc    18960

ccagaaattt ttcgccatca agagcctcct gctcctgccc gggtcctaca cctacgagtg    19020

gaacttccgc aaggacgtca acatgatcct gcagagctcc ctcggcaacg acctgcgcac    19080

ggacggggcc tccatctcct tcaccagcat caacctctac gccaccttct tccccatggc    19140

gcacaacacg gcctccacgc tcgaggccat gctgcgcaac gacaccaacg accagtcctt    19200

caacgactac ctctcggcgg ccaacatgct ctaccccatc ccggccaacg ccaccaacgt    19260

gcccatctcc atcccctcgc gcaactgggc cgccttccgc ggctggtcct tcacgcgtct    19320

caagaccaag gagacgccct cgctgggctc cgggttcgac ccctacttcg tctactcggg    19380

ctccatcccc tacctcgacg gcaccttcta cctcaaccac accttcaaga aggtctccat    19440

caccttcgac tcctccgtca gctggcccgg caacgaccgg ctcctgacgc ccaacgagtt    19500

cgaaatcaag cgcaccgtcg acggcgaggg ctacaacgtg gcccagtgca acatgaccaa    19560

ggactggttc ctggtccaga tgctggccca ctacaacatc ggctaccagg gcttctacgt    19620

gcccgagggc tacaaggacc gcatgtactc cttcttccgc aacttccagc ccatgagccg    19680

ccaggtggtg gacgaggtca actacaagga ctaccaggcc gtcaccctgg cctaccagca    19740

caacaactcg ggcttcgtcg gctacctcgc gcccaccatg cgccagggcc agccctaccc    19800

cgccaactac ccctacccgc tcatcggcaa gagcgccgtc accagcgtca cccagaaaaa    19860

gttcctctgc gacagggtca tgtggcgcat ccccttctcc agcaacttca tgtccatggg    19920

cgcgctcacc gacctcggcc agaacatgct ctatgccaac tccgcccacg cgctagacat    19980

gaatttcgaa gtcgacccca tggatgagtc cacccttctc tatgttgtct tcgaagtctt    20040

cgacgtcgtc cgagtgcacc agccccaccg cggcgtcatc gaggccgtct acctgcgcac    20100

ccccttctcg gccggtaacg ccaccaccta agctcttgct tcttgcaagc catggccgcg    20160

ggctccggcg agcaggagct cagggccatc atccgcgacc tgggctgcgg gccctacttc    20220

ctgggcacct tcgataagcg cttcccggga ttcatggccc cgcacaagct ggcctgcgcc    20280

atcgtcaaca cggccggccg cgagaccggg ggcgagcact ggctggcctt cgcctggaac    20340

ccgcgctcga acacctgcta cctcttcgac cccttcgggt tctcggacga gcgcctcaag    20400

cagatctacc agttcgagta cgagggcctg ctgcgccgca gcgccctggc caccgaggac    20460

cgctgcgtca ccctggaaaa gtccacccag accgtgcagg gtccgcgctc ggccgcctgc    20520

gggctcttct gctgcatgtt cctgcacgcc ttcgtgcact ggcccgaccg ccccatggac    20580

aagaacccca ccatgaactt gctgacgggg gtgcccaacg gcatgctcca gtcgccccag    20640

gtggaaccca ccctgcgccg caaccaggag gcgctctacc gcttcctcaa ctcccactcc    20700

gcctactttc gctcccaccg cgcgcgcatc gagaaggcca ccgccttcga ccgcatgaat    20760

caagacatgt aaaccgtgtg tgtatgttaa atgtctttaa taaacagcac tttcatgtta    20820

cacatgcatc tgagatgatt tatttagaaa tcgaaagggt tctgccgggt ctcggcatgg    20880

cccgcgggca gggacacgtt gcggaactgg tacttggcca gccacttgaa ctcggggatc    20940

agcagtttgg gcagcggggt gtcggggaag gagtcggtcc acagcttccg cgtcagttgc    21000

agggcgccca gcaggtcggg cgcggagatc ttgaaatcgc agttgggacc cgcgttctgc    21060

gcgcgggagt tgcggtacac ggggttgcag cactggaaca ccatcagggc cgggtgcttc    21120

acgctcgcca gcaccgtcgc gtcggtgatg ctctccacgt cgaggtcctc ggcgttggcc    21180

atcccgaagg gggtcatctt gcaggtctgc cttcccatgg tgggcacgca cccgggcttg    21240

tggttgcaat cgcagtgcag ggggatcagc atcatctggg cctggtcggc gttcatcccc    21300

gggtacatgg ccttcatgaa agcctccaat tgcctgaacg cctgctgggc cttggctccc    21360

tcggtgaaga agaccccgca ggacttgcta gagaactggt tggtggcgca cccggcgtcg    21420

tgcacgcagc agcgcgcgtc gttgttggcc agctgcacca cgctgcgccc ccagcggttc    21480

tgggtgatct tggcccggtc ggggttctcc ttcagcgcgc gctgcccgtt ctcgctcgcc    21540

acatccatct cgatcatgtg ctccttctgg atcatggtgg tcccgtgcag gcaccgcagc    21600

ttgccctcgg cctcggtgca cccgtgcagc cacagcgcgc acccggtgca ctcccagttc    21660

ttgtgggcga tctgggaatg cgcgtgcacg aagccctgca ggaagcggcc catcatggtg    21720

gtcagggtct tgttgctagt gaaggtcagc ggaatgccgc ggtgctcctc gttgatgtac    21780

aggtggcaga tgcggcggta cacctcgccc tgctcgggca tcagctggaa gttggctttc    21840

aggtcggtct ccacgcggta gcggtccatc agcatagtca tgatttccat acccttctcc    21900

caggccgaga cgatgggcag gctcataggg ttcttcacca tcatcttagc gctagcagcc    21960

gcggccaggg ggtcgctctc gtccagggtc tcaaagctcc gcttgccgtc cttctcggtg    22020

atccgcaccg gggggtagct gaagcccacg gccgccagct cctcctcggc ctgtctttcg    22080

tcctcgctgt cctggctgac gtcctgcagg accacatgct tggtcttgcg gggtttcttc    22140

ttgggcggca gcggcggcgg agatgttgga gatggcgagg gggagcgcga gttctcgctc    22200

accactacta tctcttcctc ttcttggtcc gaggccacgc ggcggtaggt atgtctcttc    22260

gggggcagag gcggaggcga cgggctctcg ccgccgcgac ttggcggatg gctggcagag    22320

ccccttccgc gttcgggggt gcgctcccgg cggcgctctg actgacttcc tccgcggccg    22380

gccattgtgt tctcctaggg aggaacaaca agcatggaga ctcagccatc gccaacctcg    22440

ccatctgccc ccaccgccga cgagaagcag cagcagcaga atgaaagctt aaccgccccg    22500

ccgcccagcc ccgccacctc cgacgcggcc gtcccagaca tgcaagagat ggaggaatcc    22560

atcgagattg acctgggcta tgtgacgccc gcggagcacg aggaggagct ggcagtgcgc    22620

ttttcacaag aagagataca ccaagaacag ccagagcagg aagcagagaa tgagcagagt    22680

caggctgggc tcgagcatga cggcgactac ctccacctga gcggggggga ggacgcgctc    22740

atcaagcatc tggcccggca ggccaccatc gtcaaggatg cgctgctcga ccgcaccgag    22800

gtgcccctca gcgtggagga gctcagccgc gcctacgagt tgaacctctt ctcgccgcgc    22860

gtgcccccca agcgccagcc caatggcacc tgcgagccca acccgcgcct caacttctac    22920

ccggtcttcg cggtgcccga ggccctggcc acctaccaca tctttttcaa gaaccaaaag    22980

atccccgtct cctgccgcgc caaccgcacc cgcgccgacg cccttttcaa cctgggtccc    23040

ggcgcccgcc tacctgatat cgcctccttg gaagaggttc ccaagatctt cgagggtctg    23100

ggcagcgacg agactcgggc cgcgaacgct ctgcaaggag aaggaggaga gcatgagcac    23160

cacagcgccc tggtcgagtt ggaaggcgac aacgcgcggc tggcggtgct caaacgcacg    23220

gtcgagctga cccatttcgc ctacccggct ctgaacctgc cccccaaagt catgagcgcg    23280

gtcatggacc aggtgctcat caagcgcgcg tcgcccatct ccgaggacga gggcatgcaa    23340

gactccgagg agggcaagcc cgtggtcagc gacgagcagc tggcccggtg gctgggtcct    23400

aatgctagtc cccagagttt ggaagagcgg cgcaaactca tgatggccgt ggtcctggtg    23460

accgtggagc tggagtgcct gcgccgcttc ttcgccgacg cggagaccct gcgcaaggtc    23520

gaggagaacc tgcactacct cttcaggcac gggttcgtgc gccaggcctg caagatctcc    23580

aacgtggagc tgaccaacct ggtctcctac atgggcatct tgcacgagaa ccgcctgggg    23640

cagaacgtgc tgcacaccac cctgcgcggg gaggcccggc gcgactacat ccgcgactgc    23700

gtctacctct acctctgcca cacctggcag acgggcatgg gcgtgtggca gcagtgtctg    23760

gaggagcaga acctgaaaga gctctgcaag ctcctgcaga agaacctcaa gggtctgtgg    23820

accgggttcg acgagcgcac caccgcctcg gacctggccg acctcatttt ccccgagcgc    23880

ctcaggctga cgctgcgcaa cggcctgccc gactttatga gccaaagcat gttgcaaaac    23940

tttcgctctt tcatcctcga acgctccgga atcctgcccg ccacctgctc cgcgctgccc    24000

tcggacttcg tgccgctgac cttccgcgag tgccccccgc cgctgtggag ccactgctac    24060

ctgctgcgcc tggccaacta cctggcctac cactcggacg tgatcgagga cgtcagcggc    24120

gagggcctgc tcgagtgcca ctgccgctgc aacctctgca cgccgcaccg ctccctggcc    24180

tgcaaccccc agctgctgag cgagacccag atcatcggca ccttcgagtt gcaagggccc    24240

agcgaaggcg agggttcagc cgccaagggg ggtctgaaac tcaccccggg gctgtggacc    24300

tcggcctact tgcgcaagtt cgtgcccgag gactaccatc ccttcgagat caggttctac    24360

gaggaccaat cccatccgcc caaggccgag ctgtcggcct gcgtcatcac ccagggggcg    24420

atcctggccc aattgcaagc catccagaaa tcccgccaag aattcttgct gaaaaagggc    24480

cgcggggtct acctcgaccc ccagaccggt gaggagctca accccggctt cccccaggat    24540

gccccgagga aacaagaagc tgaaagtgga gctgccgccc gtggaggatt tggaggaaga    24600

ctgggagaac agcagtcagg cagaggagga ggagatggag gaagactggg acagcactca    24660

ggcagaggag gacagcctgc aagacagtct ggaggaagac gaggaggagg cagaggagga    24720

ggtggaagaa gcagccgccg ccagaccgtc gtcctcggcg ggggagaaag caagcagcac    24780

ggataccatc tccgctccgg gtcggggtcc cgctcgacca cacagtagat gggacgagac    24840

cggacgattc ccgaacccca ccacccagac cggtaagaag gagcggcagg gatacaagtc    24900

ctggcggggg cacaaaaacg ccatcgtctc ctgcttgcag gcctgcgggg gcaacatctc    24960

cttcacccgg cgctacctgc tcttccaccg cggggtgaac tttccccgca acatcttgca    25020

ttactaccgt cacctccaca gcccctacta cttccaagaa gaggcagcag cagcagaaaa    25080

agaccagcag aaaaccagca gctagaaaat ccacagcggc ggcagcaggt ggactgagga    25140

tcgcggcgaa cgagccggcg caaacccggg agctgaggaa ccggatcttt cccaccctct    25200

atgccatctt ccagcagagt cgggggcagg agcaggaact gaaagtcaag aaccgttctc    25260

tgcgctcgct cacccgcagt tgtctgtatc acaagagcga agaccaactt cagcgcactc    25320

tcgaggacgc cgaggctctc ttcaacaagt actgcgcgct cactcttaaa gagtagcccg    25380

cgcccgccca gtcgcagaaa aaggcgggaa ttacgtcacc tgtgcccttc gccctagccg    25440

cctccaccca tcatcatgag caaagagatt cccacgcctt acatgtggag ctaccagccc    25500

cagatgggcc tggccgccgg tgccgcccag gactactcca cccgcatgaa ttggctcagc    25560

gccgggcccg cgatgatctc acgggtgaat gacatccgcg cccaccgaaa ccagatactc    25620

ctagaacagt cagcgctcac cgccacgccc cgcaatcacc tcaatccgcg taattggccc    25680

gccgccctgg tgtaccagga aattccccag cccacgaccg tactacttcc gcgagacgcc    25740

caggccgaag tccagctgac taactcaggt gtccagctgg cgggcggcgc caccctgtgt    25800

cgtcaccgcc ccgctcaggg tataaagcgg ctggtgatcc ggggcagagg cacacagctc    25860

aacgacgagg tggtgagctc ttcgctgggt ctgcgacctg acggagtctt ccaactcgcc    25920

ggatcgggga gatcttcctt cacgcctcgt caggccgtcc tgactttgga gagttcgtcc    25980

tcgcagcccc gctcgggtgg catcggcact ctccagttcg tggaggagtt cactccctcg    26040

gtctacttca accccttctc cggctccccc ggccactacc cggacgagtt catcccgaac    26100

ttcgacgcca tcagcgagtc ggtggacggc tacgattgag tttaaactca cccccttatc    26160

cagtgaaata aagatcatat tgatgatgat tttacagaaa taaaaaataa tcatttgatt    26220

tgaaataaag atacaatcat attgatgatt tgagtttaac aaaaaaataa agaatcactt    26280

acttgaaatc tgataccagg tctctgtcca tgttttctgc caacaccact tcactcccct    26340

cttcccagct ctggtactgc aggccccggc gggctgcaaa cttcctccac acgctgaagg    26400

ggatgtcaaa ttcctcctgt ccctcaatct tcattttatc ttctatcaga tgtccaaaaa    26460

gcgcgtccgg gtggatgatg acttcgaccc cgtctacccc tacgatgcag acaacgcacc    26520

gaccgtgccc ttcatcaacc cccccttcgt ctcttcagat ggattccaag agaagcccct    26580

gggggtgttg tccctgcgac tggccgaccc cgtcaccacc aagaacgggg aaatcaccct    26640

caagctggga gagggggtgg acctcgattc ctcgggaaaa ctcatctcca acacggccac    26700

caaggccgcc gcccctctca gtttttccaa caacaccatt tcccttaaca tggatcaccc    26760

cttttacact aaagatggaa aattatcctt acaagtttct ccaccattaa atatactgag    26820

aacaagcatt ctaaacacac tagctttagg ttttggatca ggtttaggac tccgtggctc    26880

tgccttggca gtacagttag tctctccact tacatttgat actgatggaa acataaagct    26940

taccttagac agaggtttgc atgttacaac aggagatgca attgaaagca acataagctg    27000

ggctaaaggt ttaaaatttg aagatggagc catagcaacc aacattggaa atgggttaga    27060

gtttggaagc agtagtacag aaacaggtgt tgatgatgct tacccaatcc aagttaaact    27120

tggatctggc cttagctttg acagtacagg agccataatg gctggtaaca aagaagacga    27180

taaactcact ttgtggacaa cacctgatcc atcaccaaac tgtcaaatac tcgcagaaaa    27240

tgatgcaaaa ctaacacttt gcttgactaa atgtggtagt caaatactgg ccactgtgtc    27300

agtcttagtt gtaggaagtg gaaacctaaa ccccattact ggcaccgtaa gcagtgctca    27360

ggtgtttcta cgttttgatg caaacggtgt tcttttaaca gaacattcta cactaaaaaa    27420

atactggggg tataggcagg gagatagcat agatggcact ccatatacca atgctgtagg    27480

attcatgccc aatttaaaag cttatccaaa gtcacaaagt tctactacta aaaataatat    27540

agtagggcaa gtatacatga atggagatgt ttcaaaacct atgcttctca ctataaccct    27600

caatggtact gatgacagca acagtacata ttcaatgtca ttttcataca cctggactaa    27660

tggaagctat gttggagcaa catttggggc taactcttat accttctcat acatcgccca    27720

agaatgaaca ctgtatccca ccctgcatgc caacccttcc caccccactc tgtggaacaa    27780

actctgaaac acaaaataaa ataaagttca agtgttttat tgattcaaca gtttcacaga    27840

accctagtat tcaacctgcc acctccctcc caacacacag agtacacagt cctttctccc    27900

cggctggcct taaaaagcat catatcatgg gtaacagaca tattcttagg tgttatattc    27960

cacacggttt cctgtcgagc caaacgctca tcagtgatat taataaactc cccgggcagc    28020

tcacttaagt tcatgtcgct gtccagctgc tgagccacag gctgctgtcc aacttgcggt    28080

tgcttaacgg gcggcgaagg agaagtccac gcctacatgg gggtagagtc ataatcgtgc    28140

atcaggatag ggcggtggtg ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc    28200

gtcctgcagg aatacaacat ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc    28260

ataaggcgcc ttgtcctccg ggcacagcag cgcaccctga tctcacttaa atcagcacag    28320

taactgcagc acagcaccac aatattgttc aaaatcccac agtgcaaggc gctgtatcca    28380

aagctcatgg cggggaccac agaacccacg tggccatcat accacaagcg caggtagatt    28440

aagtggcgac ccctcataaa cacgctggac ataaacatta cctcttttgg catgttgtaa    28500

ttcaccacct cccggtacca tataaacctc tgattaaaca tggcgccatc caccaccatc    28560

ctaaaccagc tggccaaaac ctgcccgccg gctatacact gcagggaacc gggactggaa    28620

caatgacagt ggagagccca ggactcgtaa ccatggatca tcatgctcgt catgatatca    28680

atgttggcac aacacaggca cacgtgcata cacttcctca ggattacaag ctcctcccgc    28740

gttagaacca tatcccaggg aacaacccat tcctgaatca gcgtaaatcc cacactgcag    28800

ggaagacctc gcacgtaact cacgttgtgc attgtcaaag tgttacattc gggcagcagc    28860

ggatgatcct ccagtatggt agcgcgggtt tctgtctcaa aaggaggtag acgatcccta    28920

ctgtacggag tgcgccgaga caaccgagat cgtgttggtc gtagtgtcat gccaaatgga    28980

acgccggacg tagtcatatt tcctgaagca aaaccaggtg cgggcgtgac aaacagatct    29040

gcgtctccgg tctcgccgct tagatcgctc tgtgtagtag ttgtagtata tccactctct    29100

caaagcatcc aggcgccccc tggcttcggg ttctatgtaa actccttcat gcgccgctgc    29160

cctgataaca tccaccaccg cagaataagc cacacccagc caacctacac attcgttctg    29220

cgagtcacac acgggaggag cgggaagagc tggaagaacc atgattaact ttattccaaa    29280

cggtctcgga gcacttcaaa atgcaggtcc cggaggtggc acctctcgcc cccactgtgt    29340

tggtggaaaa taacagccag gtcaaaggtg acacggttct cgagatgttc cacggtggct    29400

tccagcaaag cctccacgcg cacatccaga aacaagagga cagcgaaagc gggagcgttt    29460

tctaattcct caatcatcat attacactcc tgcaccatcc ccagataatt ttcatttttc    29520

cagccttgaa tgattcgtat tagttcctga ggtaaatcca agccagccat gataaaaagc    29580

tcgcgcagag cgccctccac cggcattctt aagcacaccc tcataattcc aagagattct    29640

gctcctggtt cacctgcagc agattaacaa tgggaatatc aaaatctctg ccgcgatccc    29700

taagctcctc cctcaacaat aactgtatgt aatctttcat atcatctccg aaatttttag    29760

ccatagggcc gccaggaata agagcagggc aagccacatt acagataaag cgaagtcctc    29820

cccagtgwgc attgccaaat gtaagattga aataagcatg ctggctagac cctgtgatat    29880

cttccagata actggacaga aaatcaggca agcaattttt aagaaaatca acaaaagaaa    29940

agtcgtccag gtgcaggttt agagcctcag gaacaacgat ggaataagtg caaggagtgc    30000

gttccagcat ggttagtgtt tttttggtga tctgtagaac aaaaaataaa catgcaatat    30060

taaaccatgc tagcctggcg aacaggtggg taaatcactc tttccagcac caggcaggct    30120

acggggtctc cggcgcgacc ctcgtagaag ctgtcgccat gattgaaaag catcaccgag    30180

agaccttccc ggtggccggc atggatgatt cgagaagaag catacactcc gggaacattg    30240

gcatccgtga gtgaaaaaaa gcgacctata aagcctcggg gcactacaat gctcaatctc    30300

aattccagca aagccacccc atgcggatgg agcacaaaat tggcaggtgc gtaaaaaatg    30360

taattactcc cctcctgcac aggcagcaaa gcccccgctc cctccagaaa cacatacaaa    30420

gcctcagcgt ccatagctta ccgagcacgg caggcgcaag agtcagagaa aaggctgagc    30480

tctaacctga ctgcccgctc ctgtgctcaa tatatagccc taacctacac tgacgtaaag    30540

gccaaagtct aaaaataccc gccaaataat cacacacgcc cagcacacgc ccagaaaccg    30600

gtgacacact caaaaaaata cgcgcacttc ctcaaacgcc caaaactgcc gtcatttccg    30660

ggttcccacg ctacgtcatc aaaacacgac tttcaaattc cgtcgaccgt taaaaacgtc    30720

acccgccccg cccctaacgg tcgcccgtct ctcagccaat cagcgccccg catccccaaa    30780

ttcaaacacc tcatttgcat attaacgcgc acaaaaagtt tgaggtatat tattgatgat    30840

gg                                                                   30842


<210>  3
<211>  1301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of tPA - 2816 Spike Protein fusion (tPA 
       underlined) (AZD2816)

<400>  3

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn 
        35                  40                  45              


Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr 
    50                  55                  60                  


Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His 
65                  70                  75                  80  


Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe 
                85                  90                  95      


His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala Asn 
            100                 105                 110         


Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys 
        115                 120                 125             


Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys 
    130                 135                 140                 


Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys 
145                 150                 155                 160 


Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr 
                165                 170                 175     


His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser 
            180                 185                 190         


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
        195                 200                 205             


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
    210                 215                 220                 


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
225                 230                 235                 240 


Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
                245                 250                 255     


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
            260                 265                 270         


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
        275                 280                 285             


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
    290                 295                 300                 


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
305                 310                 315                 320 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
                325                 330                 335     


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
            340                 345                 350         


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
        355                 360                 365             


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
    370                 375                 380                 


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
385                 390                 395                 400 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
                405                 410                 415     


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
            420                 425                 430         


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp 
        435                 440                 445             


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
    450                 455                 460                 


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
465                 470                 475                 480 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
                485                 490                 495     


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys 
            500                 505                 510         


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
        515                 520                 525             


Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
    530                 535                 540                 


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
545                 550                 555                 560 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
                565                 570                 575     


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
            580                 585                 590         


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
        595                 600                 605             


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
    610                 615                 620                 


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
625                 630                 635                 640 


Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
                645                 650                 655     


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
            660                 665                 670         


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
        675                 680                 685             


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
    690                 695                 700                 


Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile 
705                 710                 715                 720 


Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr Ser 
                725                 730                 735     


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
            740                 745                 750         


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
        755                 760                 765             


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
    770                 775                 780                 


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
785                 790                 795                 800 


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
                805                 810                 815     


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
            820                 825                 830         


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
        835                 840                 845             


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
    850                 855                 860                 


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
865                 870                 875                 880 


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
                885                 890                 895     


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
            900                 905                 910         


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
        915                 920                 925             


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
    930                 935                 940                 


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
945                 950                 955                 960 


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
                965                 970                 975     


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
            980                 985                 990         


Gln Leu Ser Ser Asn Phe Gly Ala  Ile Ser Ser Val Leu  Asn Asp Ile 
        995                 1000                 1005             


Leu Ser  Arg Leu Asp Lys Val  Glu Ala Glu Val Gln  Ile Asp Arg 
    1010                 1015                 1020             


Leu Ile  Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
    1025                 1030                 1035             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1040                 1045                 1050             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1055                 1060                 1065             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1070                 1075                 1080             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1085                 1090                 1095             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1100                 1105                 1110             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1115                 1120                 1125             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1130                 1135                 1140             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1145                 1150                 1155             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1160                 1165                 1170             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1175                 1180                 1185             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1190                 1195                 1200             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1205                 1210                 1215             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1220                 1225                 1230             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1235                 1240                 1245             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1250                 1255                 1260             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1265                 1270                 1275             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1280                 1285                 1290             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1295                 1300     


<210>  4
<211>  3915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AZD1222 codon optimised with tPA leader

<400>  4
atggacgcca tgaagcgagg cctgtgctgt gttctgcttc tgtgtggcgc cgtgtttgtg       60

tccgccagcc aagagatcca cgccagattt cggagattcg tgttcctggt gctgctgcca      120

ctggtgtcta gccagtgtgt gaacctgacc accaggacac agctgcctcc agcctacacc      180

aacagcttca ccagaggcgt gtactaccca gacaaggtgt tcagatccag cgtgctgcac      240

tctacccagg acctgttcct gcctttcttc agcaacgtga cctggttcca cgccatccac      300

gtgtccggca ccaatggcac caagagattc gacaacccag tgctgccctt caacgacgga      360

gtgtactttg ccagcaccga gaagtccaac atcatcagag gctggatctt cggcaccaca      420

ctggacagca agacccagag cctgctgatc gtgaacaacg ccaccaacgt ggtcatcaaa      480

gtgtgcgagt tccagttctg caacgaccca ttcctgggcg tctactacca caagaacaac      540

aagagctgga tggaaagcga gttccgggtg tacagcagcg ccaacaactg caccttcgag      600

tacgtgtccc agcctttcct gatggacctg gaaggcaagc agggcaactt caagaacctg      660

cgcgagttcg tgttcaagaa catcgacggc tacttcaaga tctacagcaa gcacacacct      720

atcaacctcg tgcgggatct gcctcagggc ttctctgctc tggaaccact ggtggatctg      780

cccatcggca tcaacatcac ccggtttcag acactgctgg ccctgcacag aagctacctg      840

acacctggcg atagcagctc tggatggaca gctggcgccg ctgcctacta tgtgggatac      900

ctgcagcctc ggaccttcct gctgaagtac aacgagaacg gcaccatcac cgacgccgtg      960

gattgtgctc tggatcctct gagcgagaca aagtgcaccc tgaagtcctt caccgtggaa     1020

aagggcatct accagaccag caacttccgg gtgcagccca ccgaatccat cgtgcggttc     1080

ccgaatatca ccaatctgtg cccattcggc gaggtgttca atgccaccag attcgcctct     1140

gtgtacgcct ggaaccggaa gcggatcagc aattgcgtgg ccgactactc cgtgctgtac     1200

aactccgcca gcttcagcac cttcaagtgc tacggcgtgt cacctaccaa gctgaacgac     1260

ctgtgcttca caaacgtgta cgccgacagc ttcgtgatcc gtggagatga agtgcggcag     1320

attgcacctg gacagacagg caagatcgcc gactacaact acaagctgcc cgacgacttc     1380

accggctgtg tgattgcctg gaacagcaac aacctggata gcaaagtcgg cggcaactac     1440

aattacctgt accggctgtt ccggaagtcc aatctgaagc ccttcgagcg ggacatctcc     1500

accgagatct atcaggccgg cagcacacct tgtaacggcg tggaaggctt caactgctac     1560

ttcccactgc agtcctacgg ctttcagccc acaaatggcg tgggctacca gccttacaga     1620

gtggtggtgc tgagcttcga gctgctgcat gctcctgcca cagtgtgcgg ccctaagaaa     1680

agcaccaatc tcgtgaagaa caaatgcgtg aacttcaact tcaacggcct gaccggcacc     1740

ggcgtgctga cagagagcaa caagaagttc ctgccattcc agcagttcgg ccgggatatc     1800

gccgatacca cagatgccgt cagagatcct cagacactgg aaatcctgga catcacacct     1860

tgcagcttcg gcggagtgtc tgtgatcacg cctggcacca acaccagcaa tcaggtggca     1920

gtgctgtacc aggacgtgaa ctgtaccgaa gtgcccgtgg ccattcacgc cgatcagctg     1980

acacctacat ggcgggtgta ctccaccggc agcaatgtgt ttcagaccag agccggctgt     2040

ctgatcggag ccgagcacgt gaacaatagc tacgagtgcg acatccctat cggcgctggc     2100

atctgcgcct cttaccagac acagacaaac agccctagac gggccagatc tgtggccagc     2160

cagagcatca ttgcctacac aatgtctctg ggcgccgaga acagcgtggc ctactccaac     2220

aactctatcg ctatcccgac caacttcacc atcagcgtga ccacagagat cctgcctgtg     2280

tccatgacca agaccagcgt ggactgcacc atgtacatct gcggcgattc caccgagtgc     2340

tccaacctgc tgctgcagta cggcagcttc tgcacccagc tgaatagagc cctgacaggg     2400

atcgccgtgg aacaggacaa gaacacccaa gaggtgttcg cccaagtgaa gcagatctac     2460

aagacgcctc ctatcaagga cttcggcggc ttcaatttca gccagattct gcccgatcct     2520

agcaagccca gcaagcggag cttcatcgag gacctgctgt tcaacaaagt gacactggcc     2580

gacgccggct tcatcaagca gtatggcgat tgtctgggcg acattgccgc cagggatctg     2640

atttgcgccc agaagtttaa cggactgaca gtgctgcctc ctctgctgac cgatgagatg     2700

atcgcccagt acacatctgc cctgctggcc ggcacaatca caagcggctg gacatttgga     2760

gctggcgctg ccctgcagat cccatttgct atgcagatgg cctaccggtt caacggcatc     2820

ggagtgaccc agaatgtgct gtacgagaac cagaagctga tcgccaacca gttcaacagc     2880

gccatcggca agatccagga cagcctgagc agcacagcaa gcgccctggg aaagctgcag     2940

gacgtggtca accagaatgc ccaggcactg aacaccctgg tcaagcagct gtctagcaac     3000

ttcggcgcca tcagctctgt gctgaacgat atcctgagca gactggacaa ggtggaagcc     3060

gaggtgcaga tcgacagact gatcaccgga aggctgcagt ccctgcagac ctacgttacc     3120

cagcagctga tcagagccgc cgagattaga gcctctgcca atctggccgc caccaagatg     3180

tctgagtgtg tgctgggcca gagcaagaga gtggactttt gcggcaaggg ctaccacctg     3240

atgagcttcc ctcagtctgc gcctcacggc gtggtgtttc tgcacgtgac atacgtgccc     3300

gctcaagaga agaatttcac caccgctcca gccatctgcc acgacggcaa agcccacttt     3360

cctagagaag gcgtgttcgt gtccaacggc acccattggt tcgtgaccca gcggaacttc     3420

tacgagcctc agatcatcac caccgacaac accttcgtgt ctggcaactg cgacgtcgtg     3480

atcggcattg tgaacaatac cgtgtacgac cctctgcagc ccgagctgga cagcttcaaa     3540

gaggaactgg ataagtactt taagaaccac acaagccctg acgtggacct gggcgatatc     3600

agcggaatca atgccagcgt cgtgaacatc cagaaagaga tcgaccggct gaacgaggtg     3660

gccaagaatc tgaacgagag cctgatcgac ctgcaagaac tgggcaagta cgagcagtac     3720

atcaagtggc cctggtacat ctggctgggc tttatcgccg gactgattgc catcgtgatg     3780

gtcacaatca tgctgtgttg catgaccagc tgctgtagct gcctgaaggg ctgttgtagc     3840

tgtggctcct gctgcaagtt cgacgaggac gattctgagc ccgtgctgaa gggcgtgaaa     3900

ctgcactaca cctga                                                      3915


<210>  5
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA amino acid sequence (P->A mutant)

<400>  5

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


<210>  6
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA amino acid sequence (naturally occurring P)

<400>  6

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA amino acid sequence SEQ ID NO: 5 without 'RR'

<400>  7

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser Gln Glu Ile His Ala Arg Phe 
            20                  25                  30  


<210>  8
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tPA amino acid sequence SEQ ID NO: 6 without 'RR'

<400>  8

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe 
            20                  25                  30  


<210>  9
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding tPA SEQ ID NO: 5, which has been 
       codon optimised for human codon usage

<400>  9
atggacgcca tgaagagggg cctgtgctgc gtgctgctgc tgtgtggcgc cgtgtttgtg       60

tccgccagcc aggaaatcca cgcccggttc agacgg                                 96


<210>  10
<211>  1304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of tPA-Spike fusion (tPA underlined) (i.e. 
       amino acid sequence encoded by SEQ ID NO: 4) (reference sequence)
       (AZD1222)

<400>  10

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn 
        35                  40                  45              


Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr 
    50                  55                  60                  


Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His 
65                  70                  75                  80  


Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe 
                85                  90                  95      


His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn 
            100                 105                 110         


Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys 
        115                 120                 125             


Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys 
    130                 135                 140                 


Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys 
145                 150                 155                 160 


Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr 
                165                 170                 175     


His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser 
            180                 185                 190         


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
        195                 200                 205             


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
    210                 215                 220                 


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
225                 230                 235                 240 


Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
                245                 250                 255     


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
            260                 265                 270         


Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
        275                 280                 285             


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
    290                 295                 300                 


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
305                 310                 315                 320 


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
                325                 330                 335     


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
            340                 345                 350         


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
        355                 360                 365             


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
    370                 375                 380                 


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
385                 390                 395                 400 


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
                405                 410                 415     


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
            420                 425                 430         


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
        435                 440                 445             


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
    450                 455                 460                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
465                 470                 475                 480 


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
                485                 490                 495     


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
            500                 505                 510         


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
        515                 520                 525             


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
    530                 535                 540                 


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
545                 550                 555                 560 


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
                565                 570                 575     


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
            580                 585                 590         


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
        595                 600                 605             


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly 
    610                 615                 620                 


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala 
625                 630                 635                 640 


Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His 
                645                 650                 655     


Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn 
            660                 665                 670         


Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
        675                 680                 685             


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
    690                 695                 700                 


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser 
705                 710                 715                 720 


Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val 
                725                 730                 735     


Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser 
            740                 745                 750         


Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp 
        755                 760                 765             


Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu 
    770                 775                 780                 


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly 
785                 790                 795                 800 


Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val 
                805                 810                 815     


Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn 
            820                 825                 830         


Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe 
        835                 840                 845             


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe 
    850                 855                 860                 


Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu 
865                 870                 875                 880 


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
                885                 890                 895     


Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr 
            900                 905                 910         


Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
        915                 920                 925             


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
    930                 935                 940                 


Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser 
945                 950                 955                 960 


Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu 
                965                 970                 975     


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
            980                 985                 990         


Leu Val Lys Gln Leu Ser Ser Asn  Phe Gly Ala Ile Ser  Ser Val Leu 
        995                 1000                 1005             


Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val Glu Ala  Glu Val Gln 
    1010                 1015                 1020             


Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln Ser Leu  Gln Thr Tyr 
    1025                 1030                 1035             


Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
    1040                 1045                 1050             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1055                 1060                 1065             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1070                 1075                 1080             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1085                 1090                 1095             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1100                 1105                 1110             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1115                 1120                 1125             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1130                 1135                 1140             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1145                 1150                 1155             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1160                 1165                 1170             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1175                 1180                 1185             


Asn His  Thr Ser Pro Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile 
    1190                 1195                 1200             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1205                 1210                 1215             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1220                 1225                 1230             


Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp 
    1235                 1240                 1245             


Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile Val Met  Val Thr Ile 
    1250                 1255                 1260             


Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys 
    1265                 1270                 1275             


Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu 
    1280                 1285                 1290             


Pro Val  Leu Lys Gly Val Lys  Leu His Tyr Thr 
    1295                 1300                 


<210>  11
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence from SARS-CoV2 (nCoV 19) genome for spike 
       protein (From Accession number MG772933.1)

<400>  11
atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc       60

agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac      120

aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc      180

aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat      240

aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata      300

ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt      360

aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt      420

ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat      480

tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa      540

ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat      600

tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt      660

tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact      720

ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct      780

ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat      840

gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag      900

tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc      960

caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa     1020

gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac     1080

tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat     1140

ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt     1200

gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat     1260

tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat     1320

cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat     1380

ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt     1440

aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact     1500

aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca     1560

ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat     1620

ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg     1680

cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag     1740

acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca     1800

ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc     1860

cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct     1920

aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat     1980

gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct     2040

cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt     2100

gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt     2160

agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg     2220

tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt     2280

acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa     2340

gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt     2400

aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat     2460

ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc     2520

cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt     2580

ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt     2640

acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg     2700

caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa     2760

aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc     2820

acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac     2880

acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc     2940

ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga     3000

cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct     3060

tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt     3120

gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta     3180

gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc     3240

atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca     3300

cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca     3360

tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct     3420

ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca     3480

tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa     3540

aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc     3600

caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt     3660

atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc     3720

tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac     3780

tctgagccag tgctcaaagg agtcaaatta cattacacat aa                        3822


<210>  12
<211>  1301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of tPA - 3990 Spike Protein fusion (tPA 
       underlined) (Proline substitutions relative to SEQ ID NO: 1/SEQ 
       ID NO: 3 in bold) (AZD3990)

<400>  12

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn 
        35                  40                  45              


Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr 
    50                  55                  60                  


Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His 
65                  70                  75                  80  


Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe 
                85                  90                  95      


His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala Asn 
            100                 105                 110         


Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys 
        115                 120                 125             


Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys 
    130                 135                 140                 


Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys 
145                 150                 155                 160 


Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr 
                165                 170                 175     


His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser 
            180                 185                 190         


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
        195                 200                 205             


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
    210                 215                 220                 


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
225                 230                 235                 240 


Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
                245                 250                 255     


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
            260                 265                 270         


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
        275                 280                 285             


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
    290                 295                 300                 


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
305                 310                 315                 320 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
                325                 330                 335     


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
            340                 345                 350         


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
        355                 360                 365             


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
    370                 375                 380                 


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
385                 390                 395                 400 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
                405                 410                 415     


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
            420                 425                 430         


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp 
        435                 440                 445             


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
    450                 455                 460                 


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
465                 470                 475                 480 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
                485                 490                 495     


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys 
            500                 505                 510         


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
        515                 520                 525             


Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
    530                 535                 540                 


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
545                 550                 555                 560 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
                565                 570                 575     


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
            580                 585                 590         


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
        595                 600                 605             


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
    610                 615                 620                 


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
625                 630                 635                 640 


Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
                645                 650                 655     


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
            660                 665                 670         


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
        675                 680                 685             


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
    690                 695                 700                 


Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile 
705                 710                 715                 720 


Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr Ser 
                725                 730                 735     


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
            740                 745                 750         


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
        755                 760                 765             


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
    770                 775                 780                 


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
785                 790                 795                 800 


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
                805                 810                 815     


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
            820                 825                 830         


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp 
        835                 840                 845             


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
    850                 855                 860                 


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
865                 870                 875                 880 


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
                885                 890                 895     


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
            900                 905                 910         


Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met 
        915                 920                 925             


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
    930                 935                 940                 


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
945                 950                 955                 960 


Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu 
                965                 970                 975     


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
            980                 985                 990         


Gln Leu Ser Ser Asn Phe Gly Ala  Ile Ser Ser Val Leu  Asn Asp Ile 
        995                 1000                 1005             


Leu Ser  Arg Leu Asp Pro Pro  Glu Ala Glu Val Gln  Ile Asp Arg 
    1010                 1015                 1020             


Leu Ile  Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
    1025                 1030                 1035             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1040                 1045                 1050             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1055                 1060                 1065             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1070                 1075                 1080             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1085                 1090                 1095             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1100                 1105                 1110             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1115                 1120                 1125             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1130                 1135                 1140             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1145                 1150                 1155             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1160                 1165                 1170             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1175                 1180                 1185             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1190                 1195                 1200             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1205                 1210                 1215             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1220                 1225                 1230             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1235                 1240                 1245             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1250                 1255                 1260             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1265                 1270                 1275             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1280                 1285                 1290             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1295                 1300     


<210>  13
<211>  44095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AZD2816 plasmid : p5841 pDEST ChAdOx1 nCoV-19E DNA Sequence

<400>  13
gcggccgcca ggcctaccca ctagtcaatt cgggaggatc gaaacggcag atcgcaaaaa       60

acagtacata cagaaggaga catgaacatg aacatcaaaa aaattgtaaa acaagccaca      120

gttctgactt ttacgactgc acttctggca ggaggagcga ctcaagcctt cgcgaaagaa      180

aataaccaaa aagcatacaa agaaacgtac ggcgtctctc atattacacg ccatgatatg      240

ctgcagatcc ctaaacagca gcaaaacgaa aaataccaag tgcctcaatt cgatcaatca      300

acgattaaaa atattgagtc tgcaaaagga cttgatgtgt gggacagctg gccgctgcaa      360

aacgctgacg gaacagtagc tgaatacaac ggctatcacg ttgtgtttgc tcttgcggga      420

agcccgaaag acgctgatga cacatcaatc tacatgtttt atcaaaaggt cggcgacaac      480

tcaatcgaca gctggaaaaa cgcgggccgt gtctttaaag acagcgataa gttcgacgcc      540

aacgatccga tcctgaaaga tcagacgcaa gaatggtccg gttctgcaac ctttacatct      600

gacggaaaaa tccgtttatt ctacactgac tattccggta aacattacgg caaacaaagc      660

ctgacaacag cgcaggtaaa tgtgtcaaaa tctgatgaca cactcaaaat caacggagtg      720

gaagatcaca aaacgatttt tgacggagac ggaaaaacat atcagaacgt tcagcagttt      780

atcgatgaag gcaattatac atccggcgac aaccatacgc tgagagaccc tcactacgtt      840

gaagacaaag gccataaata ccttgtattc gaagccaaca cgggaacaga aaacggatac      900

caaggcgaag aatctttatt taacaaagcg tactacggcg gcggcacgaa cttcttccgt      960

aaagaaagcc agaagcttca gcagagcgct aaaaaacgcg atgctgagtt agcgaacggc     1020

gccctcggta tcatagagtt aaataatgat tacacattga aaaaagtaat gaagccgctg     1080

atcacttcaa acacggtaac tgatgaaatc gagcgcgcga atgttttcaa aatgaacggc     1140

aaatggtact tgttcactga ttcacgcggt tcaaaaatga cgatcgatgg tattaactca     1200

aacgatattt acatgcttgg ttatgtatca aactctttaa ccggccctta caagccgctg     1260

aacaaaacag ggcttgtgct gcaaatgggt cttgatccaa acgatgtgac attcacttac     1320

tctcacttcg cagtgccgca agccaaaggc aacaatgtgg ttatcacaag ctacatgaca     1380

aacagaggct tcttcgagga taaaaaggca acatttgcgc caagcttctt aatgaacatc     1440

aaaggcaata aaacatccgt tgtcaaaaac agcatcctgg agcaaggaca gctgacagtc     1500

aactaataac agcaaaaaga aaatgccgat acttcattgg cattttcttt tatttctcaa     1560

caagatggtg aattgactag tgggtagatc cacaggacgg gtgtggtcgc catgatcgcg     1620

tagtcgatag tggctccaag tagcgaagcg agcaggactg ggcggcggcc aaagcggtcg     1680

gacagtgctc cgagaacggg tgcgcataga aattgcatca acgcatatag cgctagcagc     1740

acgccatagt gactggcgat gctgtcggaa tggacgatat cccgcaagag gcccggcagt     1800

accggcataa ccaagcctat gcctacagca tccagggtga cggtgccgag gatgacgatg     1860

agcgcattgt tagatttcat acacggtgcc tgactgcgtt agcaatttaa ctgtgataaa     1920

ctaccgcatt aaagcttatc gatgataagc tgtcaaacat gagaattgat ccggaaccct     1980

taatataact tcgtataatg tatgctatac gaagttatta ggtccctcga ctatagggtc     2040

accgtcgaca gcgacacact tgcatcggat gcagcccggt taacgtgccg gcacggcctg     2100

ggtaaccagg tattttgtcc acataaccgt gcgcaaaatg ttgtggataa gcaggacaca     2160

gcagcaatcc acagcaggca tacaaccgca caccgaggtt actccgttct acaggttacg     2220

acgacatgtc aatacttgcc cttgacaggc attgatggaa tcgtagtctc acgctgatag     2280

tctgatcgac aatacaagtg ggaccgtggt cccagaccga taatcagacc gacaacacga     2340

gtgggatcgt ggtcccagac taataatcag accgacgata cgagtgggac cgtggtccca     2400

gactaataat cagaccgacg atacgagtgg gaccgtggtt ccagactaat aatcagaccg     2460

acgatacgag tgggaccgtg gtcccagaca taataatcag accgaaccgt ggtcccagtc     2520

tgattatcag accgacgata cgagtgggac cgtggtccca gactaataat cagaccgacg     2580

atacgagtgg gaccgtggtc ccagactaat aatcagaccg acgatacgag tgggaccgtg     2640

gtcccagtct gattatcaga ccgacgatac aagtggaaca gtgggcccag agagaatatt     2700

caggccagtt atgctttctg gcctgtaaca aaggacatta agtaaagaca gataaacgta     2760

gactaaaacg tggtcgcatc agggtgctgg cttttcaagt tccttaagaa tggcctcaat     2820

tttctctata cactcagttg gaacacgaga cctgtccagg ttaagcacca ttttatcgcc     2880

cttatacaat actgtcgctc caggagcaaa ctgatgtcgt gagcttaaac tagttcttga     2940

tgcagatgac gttttaagca cagaagttaa aagagtgata acttcttcag cttcaaatat     3000

caccccagct tttttctgct catgaaggtt agatgcctgc tgcttaagta attcctcttt     3060

atctgtaaag gctttttgaa gtgcatcacc tgaccgggca gatagttcac cggggtgaga     3120

aaaaagagca acaactgatt taggcaattt ggcggtgttg atacagcggg taataatctt     3180

acgtgaaata ttttccgcat cagccagcgc agaaatattt ccagcaaatt cattctgcaa     3240

tcggcttgca taacgctgac cacgttcata agcacttgtt gggcgataat cgttacccaa     3300

tctggataat gcagccatct gctcatcatc cagctcgcca accagaacac gataatcact     3360

ttcggtaagt gcagcagctt tacgacggcg actcccatcg gcaatttcta tgacaccaga     3420

tactcttcga ccgaacgccg gtgtctgttg accagtcagt agaaaagaag ggatgagatc     3480

atccagtgcg tcctcagtaa gcagctcctg gtcacgttca ttacctgacc atacccgaga     3540

ggtcttctca acactatcac cccggagcac ttcaagagta aacttcacat cccgaccaca     3600

tacaggcaaa gtaatggcat taccgcgagc cattactcct acgcgcgcaa ttaacgaatc     3660

caccatcggg gcagctggtg tcgataacga agtatcttca accggttgag tattgagcgt     3720

atgttttgga ataacaggcg cacgcttcat tatctaatct cccagcgtgg tttaatcaga     3780

cgatcgaaaa tttcattgca gacaggttcc caaatagaaa gagcatttct ccaggcacca     3840

gttgaagagc gttgatcaat ggcctgttca aaaacagttc tcatccggat ctgaccttta     3900

ccaacttcat ccgtttcacg tacaacattt tttagaacca tgcttcccca ggcatcccga     3960

atttgctcct ccatccacgg ggactgagag ccattactat tgctgtattt ggtaagcaaa     4020

atacgtacat caggctcgaa ccctttaaga tcaacgttct tgagcagatc acgaagcata     4080

tcgaaaaact gcagtgcgga ggtgtagtca aacaactcag caggcgtggg aacaatcagc     4140

acatcagcag cacatacgac attaatcgtg ccgataccca ggttaggcgc gctgtcaata     4200

actatgacat catagtcatg agcaacagtt tcaatggcca gtcggagcat caggtgtgga     4260

tcggtgggca gtttaccttc atcaaatttg cccattaact cagtttcaat acggtgcaga     4320

gccagacagg aaggaataat gtcaagcccc ggccagcaag tgggctttat tgcataagtg     4380

acatcgtcct tttccccaag atagaaaggc aggagagtgt cttctgcatg aatatgaaga     4440

tctggtaccc atccgtgata cattgaggct gttccctggg ggtcgttacc ttccacgagc     4500

aaaacacgta gccccttcag agccagatcc tgagcaagat gaacagaaac tgaggttttg     4560

taaacgccac ctttatgggc agcaaccccg atcaccggtg gaaatacgtc ttcagcacgt     4620

cgcaatcgcg taccaaacac atcacgcata tgattaattt gttcaattgt ataaccaaca     4680

cgttgctcaa cccgtcctcg aatttccata tccgggtgcg gtagtcgccc tgctttctcg     4740

gcatctctga tagcctgaga agaaacccca actaaatccg ctgcttcacc tattctccag     4800

cgccgggtta ttttcctcgc ttccgggctg tcatcattaa actgtgcaat ggcgatagcc     4860

ttcgtcattt catgaccagc gtttatgcac tggttaagtg tttccatgag tttcattctg     4920

aacatccttt aatcattgct ttgcgttttt ttattaaatc ttgcaattta ctgcaaagca     4980

acaacaaaat cgcaaagtca tcaaaaaacc gcaaagttgt ttaaaataag agcaacacta     5040

caaaaggaga taagaagagc acatacctca gtcacttatt atcactagcg ctcgccgcag     5100

ccgtgtaacc gagcatagcg agcgaactgg cgaggaagca aagaagaact gttctgtcag     5160

atagctctta cgctcagcgc aagaagaaat atccaccgtg ggaaaaactc caggtagagg     5220

tacacacgcg gatagccaat tcagagtaat aaactgtgat aatcaaccct catcaatgat     5280

gacgaactaa cccccgatat caggtcacat gacgaaggga aagagaagga aatcaactgt     5340

gacaaactgc cctcaaattt ggcttcctta aaaattacag ttcaaaaagt atgagaaaat     5400

ccatgcaggc tgaaggaaac agcaaaactg tgacaaatta ccctcagtag gtcagaacaa     5460

atgtgacgaa ccaccctcaa atctgtgaca gataaccctc agactatcct gtcgtcatgg     5520

aagtgatatc gcggaaggaa aatacgatat gagtcgtctg gcggcctttc tttttctcaa     5580

tgtatgagag gcgcattgga gttctgctgt tgatctcatt aacacagacc tgcaggaagc     5640

ggcggcggaa gtcaggcata cgctggtaac tttgaggcag ctggtaacgc tctatgatcc     5700

agtcgatttt cagagagacg atgcctgagc catccggctt acgatactga cacagggatt     5760

cgtataaacg catggcatac ggattggtga tttcttttgt ttcactaagc cgaaactgcg     5820

taaaccggtt ctgtaacccg ataaagaagg gaatgagata tgggttgata tgtacactgt     5880

aaagccctct ggatggactg tgcgcacgtt tgataaacca aggaaaagat tcatagcctt     5940

tttcatcgcc ggcatcctct tcagggcgat aaaaaaccac ttccttcccc gcgaaactct     6000

tcaatgcctg ccgtatatcc ttactggctt ccgcagaggt caatccgaat atttcagcat     6060

atttagcaac atggatctcg cagataccgt catgttcctg tagggtgcca tcagattttc     6120

tgatctggtc aacgaacaga tacagcatac gtttttgatc ccgggagaga ctatatgccg     6180

cctcagtgag gtcgtttgac tggacgattc gcgggctatt tttacgtttc ttgtgattga     6240

taaccgctgt ttccgccatg acagatccat gtgaagtgtg acaagttttt agattgtcac     6300

actaaataaa aaagagtcaa taagcaggga taactttgtg aaaaaacagc ttcttctgag     6360

ggcaatttgt cacagggtta agggcaattt gtcacagaca ggactgtcat ttgagggtga     6420

tttgtcacac tgaaagggca atttgtcaca acaccttctc tagaaccagc atggataaag     6480

gcctacaagg cgctctaaaa aagaagatct aaaaactata aaaaaaataa ttataaaaat     6540

atccccgtgg ataagtggat aaccccaagg gaagtttttt caggcatcgt gtgtaagcag     6600

aatatataag tgctgttccc tggtgcttcc tcgctcactc gagggcttcg ccctgtcgct     6660

caactgcggc gagcactact ggctgtaaaa ggacagacca catcatggtt ctgtgttcat     6720

taggttgttc tgtccattgc tgacataatc cgctccactt caacgtaaca ccgcacgaag     6780

atttctattg ttcctgaagg catattcaaa tcgttttcgt taccgcttgc aggcatcatg     6840

acagaacact acttcctata aacgctacac aggctcctga gattaataat gcggatctct     6900

acgataatgg gagattttcc cgactgtttc gttcgcttct cagtggataa cagccagctt     6960

ctctgtttaa cagacaaaaa cagcatatcc actcagttcc acatttccat ataaaggcca     7020

aggcatttat tctcaggata attgtttcag catcgcaacc gcatcagact ccggcatcgc     7080

aaactgcacc cggtgccggg cagccacatc cagcgcaaaa accttcgtgt agacttccgt     7140

tgaactgatg gacttatgtc ccatcaggct ttgcagaact ttcagcggta taccggcata     7200

cagcatgtgc atcgcatagg aatggcggaa cgtatgtggt gtgaccggaa cagagaacgt     7260

cacaccgtca gcagcagcgg cggcaaccgc ctccccaatc caggtcctga ccgttctgtc     7320

cgtcacttcc cagatccgcg ctttctctgt ccttcctgtg cgacggttac gccgctccat     7380

gagcttatcg cgaataaata cctgtgacgg aagatcactt cgcagaataa ataaatcctg     7440

gtgtccctgt tgataccggg aagccctggg ccaacttttg gcgaaaatga gacgttgatc     7500

ggcacgtaag aggttccaac tttcaccata atgaaataag atcactaccg ggcgtatttt     7560

ttgagttatc gagattttca ggagctaagg aagctaaaat ggagaaaaaa atcactggat     7620

ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca tttcagtcag     7680

ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt ttaaagaccg     7740

taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc cgcctgatga     7800

atgctcatcc ggagttccgt atggcaatga aagacggtga gctggtgata tgggatagtg     7860

ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg ctctggagtg     7920

aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg gcgtgttacg     7980

gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc gtctcagcca     8040

atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac aacttcttcg     8100

cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg atgccgctgg     8160

cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg cttaatgaat     8220

tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc agttattggt     8280

gcccttaaac gcctggttgc tacgcctgaa taagtgataa taagcggatg aatggcagaa     8340

attcgatgat aagctgtcaa acatgagaat tggtcgacgg cgcgccaaag cttgcatgcc     8400

tgcagccgcg taacctggca aaatcggtta cggttgagta ataaatggat gccctgcgta     8460

agcggggcac atttcattac ctctttctcc gcacccgaca tagataataa cttcgtatag     8520

tatacattat acgaagttat ctagtagact taatcgcgtt taaacccatc atcaataata     8580

tacctcaaac tttttgtgcg cgttaatatg caaatgaggc gtttgaattt gggaagggag     8640

gaaggtgatt ggccgagaga agggcgaccg ttaggggcgg ggcgagtgac gttttgatga     8700

cgtgaccgcg aggaggagcc agtttgcaag ttctcgtggg aaaagtgacg tcaaacgagg     8760

tgtggtttga acacggaaat actcaatttt cccgcgctct ctgacaggaa atgaggtgtt     8820

tctaggcgga tgcaagtgaa aacgggccat tttcgcgcga aaactgaatg aggaagtgaa     8880

aatctgagta atttcgcgtt tatgacaggg aggagtattt gccgagggcc gagtagactt     8940

tgaccgatta cgtgggggtt tcgattaccg tgtttttcac ctaaatttcc gcgtacggtg     9000

tcaaagtccg gtgtttttac gtaggtgtca gctgatcgcc agggtattta aacctgcgct     9060

ctccagtcaa gaggccactc ttgagtgcca gcgagaagag ttttctcctc cgcgcgcgag     9120

tcagatctac actttgaaag gcgatcgcta gcgacatcga tcacaagttt gtacaaaaaa     9180

gcaggctcca ccatgggaac ccgcgttttg agatttctgt cgccgactaa attcatgtcg     9240

cgcgatagtg gtgtttatcg ccgatagaga tggcgatatt ggaaaaatcg atatttgaaa     9300

atatggcata ttgaaaatgt cgccgatgtg agtttctgtg taactgatat cgccattttt     9360

ccaaaagtga tttttgggca tacgcgatat ctggcgatag cgcttatatc gtttacgggg     9420

gatggcgata gacgactttg gtgacttggg cgattctgtg tgtcgcaaat atcgcagttt     9480

cgatataggt gacagacgat atgaggctat atcgccgata gaggcgacat caagctggca     9540

catggccaat gcatatcgat ctatacattg aatcaatatt ggccattagc catattattc     9600

attggttata tagcataaat caatattggc tattggccat tgcatacgtt gtatccatat     9660

cataatatgt acatttatat tggctcatgt ccaacattac cgccatgttg acattgatta     9720

ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag     9780

ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc     9840

ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga     9900

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat     9960

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc    10020

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct    10080

attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca    10140

cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat    10200

caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg    10260

cgtgtacggt gggaggtcta tataagcaga gctctcccta tcagtgatag agatctccct    10320

atcagtgata gagatcgtcg acgagctcgt ttagtgaacc gtcagatcgc ctggagacgc    10380

catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct ccgcggccgg    10440

gaacggtgca ttggaacgcg gattccccgt gccaagagtg acgtaagtac cgcctataga    10500

gtctataggc ccaccccctt ggcttcttat gcatgctata ctgtttttgg cttggggtct    10560

atacaccccc gcttcctcat gttataggtg atggtatagc ttagcctata ggtgtgggtt    10620

attgaccatt attgaccact cccctattgg tgacgatact ttccattact aatccataac    10680

atggctcttt gccacaactc tctttattgg ctatatgcca atacactgtc cttcagagac    10740

tgacacggac tctgtatttt tacaggatgg ggtctcattt attatttaca aattcacata    10800

tacaacacca ccgtccccag tgcccgcagt ttttattaaa cataacgtgg gatctccacg    10860

cgaatctcgg gtacgtgttc cggacatggg ctcttctccg gtagcggcgg agcttctaca    10920

tccgagccct gctcccatgc ctccagcgac tcatggtcgc tcggcagctc cttgctccta    10980

acagtggagg ccagacttag gcacagcacg atgcccacca ccaccagtgt gccgcacaag    11040

gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg agcgggcttg caccgctgac    11100

gcatttggaa gacttaaggc agcggcagaa gaagatgcag gcagctgagt tgttgtgttc    11160

tgataagagt cagaggtaac tcccgttgcg gtgctgttaa cggtggaggg cagtgtagtc    11220

tgagcagtac tcgttgctgc cgcgcgcgcc accagacata atagctgaca gactaacaga    11280

ctgttccttt ccatgggtct tttctgcagt caccgtcctt gacacgaagc ttggtacctt    11340

aatggacgcc atgaagcgag gcctgtgctg tgttctgctt ctgtgtggcg ccgtgtttgt    11400

gtccgccagc caagagatcc acgccagatt tcggagattc gtgttcctgg tgctgctgcc    11460

actggtgtct agccagtgtg tgaactttac caccaggaca cagctgcctc cagcctacac    11520

caacagcttc accagaggcg tgtactaccc agacaaggtg ttcagatcca gcgtgctgca    11580

ctctacccag gacctgttcc tgcctttctt cagcaacgtg acctggttcc acgccatcca    11640

cgtgtccggc accaatggca ccaagagatt cgccaaccca gtgctgccct tcaacgacgg    11700

agtgtacttt gccagcaccg agaagtccaa catcatcaga ggctggatct tcggcaccac    11760

actggacagc aagacccaga gcctgctgat cgtgaacaac gccaccaacg tggtcatcaa    11820

agtgtgcgag ttccagttct gcaacgaccc attcctgggc gtctactacc acaagaacaa    11880

caagagctgg atggaaagcg agttccgggt gtacagcagc gccaacaact gcaccttcga    11940

gtacgtgtcc cagcctttcc tgatggacct ggaaggcaag cagggcaact tcaagaacct    12000

gcgcgagttc gtgttcaaga acatcgacgg ctacttcaag atctacagca agcacacacc    12060

tatcaacctc gtgcggggcc tgcctcaggg cttctctgct ctggaaccac tggtggatct    12120

gcccatcggc atcaacatca cccggtttca gacactgcac agaagctacc tgacacctgg    12180

cgatagcagc tctggatgga cagctggcgc cgctgcctac tatgtgggat acctgcagcc    12240

tcggaccttc ctgctgaagt acaacgagaa cggcaccatc accgacgccg tggattgtgc    12300

tctggatcct ctgagcgaga caaagtgcac cctgaagtcc ttcaccgtgg aaaagggcat    12360

ctaccagacc agcaacttcc gggtgcagcc caccgaatcc atcgtgcggt tcccgaatat    12420

caccaatctg tgcccattcg gcgaggtgtt caatgccacc agattcgcct ctgtgtacgc    12480

ctggaaccgg aagcggatca gcaattgcgt ggccgactac tccgtgctgt acaactccgc    12540

cagcttcagc accttcaagt gctacggcgt gtcacctacc aagctgaacg acctgtgctt    12600

cacaaacgtg tacgccgaca gcttcgtgat ccgtggagat gaagtgcggc agattgcacc    12660

tggacagaca ggcaatatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg    12720

tgtgattgcc tggaacagca acaacctgga tagcaaagtc ggcggcaact acaattacct    12780

gtaccggctg ttccggaagt ccaatctgaa gcccttcgag cgggacatct ccaccgagat    12840

ctatcaggcc ggcagcacac cttgtaacgg cgtgaaaggc ttcaactgct acttcccact    12900

gcagtcctac ggctttcagc ccacatatgg cgtgggctac cagccttaca gagtggtggt    12960

gctgagcttc gagctgctgc atgctcctgc cacagtgtgc ggccctaaga aaagcaccaa    13020

tctcgtgaag aacaaatgcg tgaacttcaa cttcaacggc ctgaccggca ccggcgtgct    13080

gacagagagc aacaagaagt tcctgccatt ccagcagttc ggccgggata tcgccgatac    13140

cacagatgcc gtcagagatc ctcagacact ggaaatcctg gacatcacac cttgcagctt    13200

cggcggagtg tctgtgatca cgcctggcac caacaccagc aatcaggtgg cagtgctgta    13260

ccagggtgtg aactgtaccg aagtgcccgt ggccattcac gccgatcagc tgacacctac    13320

atggcgggtg tactccaccg gcagcaatgt gtttcagacc agagccggct gtctgatcgg    13380

agccgagcac gtgaacaata gctacgagtg cgacatccct atcggcgctg gcatctgcgc    13440

ctcttaccag acacagacaa acagccctag acgggccaga tctgtggcca gccagagcat    13500

cattgcctac acaatgtctc tgggcgtgga gaacagcgtg gcctactcca acaactctat    13560

cgctatcccg accaacttca ccatcagcgt gaccacagag atcctgcctg tgtccatgac    13620

caagaccagc gtggactgca ccatgtacat ctgcggcgat tccaccgagt gctccaacct    13680

gctgctgcag tacggcagct tctgcaccca gctgaataga gccctgacag ggatcgccgt    13740

ggaacaggac aagaacaccc aagaggtgtt cgcccaagtg aagcagatct acaagacgcc    13800

tcctatcaag gacttcggcg gcttcaattt cagccagatt ctgcccgatc ctagcaagcc    13860

cagcaagcgg agcttcatcg aggacctgct gttcaacaaa gtgacactgg ccgacgccgg    13920

cttcatcaag cagtatggcg attgtctggg cgacattgcc gccagggatc tgatttgcgc    13980

ccagaagttt aacggactga cagtgctgcc tcctctgctg accgatgaga tgatcgccca    14040

gtacacatct gccctgctgg ccggcacaat cacaagcggc tggacatttg gagctggcgc    14100

tgccctgcag atcccatttg ctatgcagat ggcctaccgg ttcaacggca tcggagtgac    14160

ccagaatgtg ctgtacgaga accagaagct gatcgccaac cagttcaaca gcgccatcgg    14220

caagatccag gacagcctga gcagcacagc aagcgccctg ggaaagctgc aggacgtggt    14280

caaccagaat gcccaggcac tgaacaccct ggtcaagcag ctgtctagca acttcggcgc    14340

catcagctct gtgctgaacg atatcctgag cagactggac aaggtggaag ccgaggtgca    14400

gatcgacaga ctgatcaccg gaaggctgca gtccctgcag acctacgtta cccagcagct    14460

gatcagagcc gccgagatta gagcctctgc caatctggcc gccaccaaga tgtctgagtg    14520

tgtgctgggc cagagcaaga gagtggactt ttgcggcaag ggctaccacc tgatgagctt    14580

ccctcagtct gcgcctcacg gcgtggtgtt tctgcacgtg acatacgtgc ccgctcaaga    14640

gaagaatttc accaccgctc cagccatctg ccacgacggc aaagcccact ttcctagaga    14700

aggcgtgttc gtgtccaacg gcacccattg gttcgtgacc cagcggaact tctacgagcc    14760

tcagatcatc accaccgaca acaccttcgt gtctggcaac tgcgacgtcg tgatcggcat    14820

tgtgaacaat accgtgtacg accctctgca gcccgagctg gacagcttca aagaggaact    14880

ggataagtac tttaagaacc acacaagccc tgacgtggac ctgggcgata tcagcggaat    14940

caatgccagc gtcgtgaaca tccagaaaga gatcgaccgg ctgaacgagg tggccaagaa    15000

tctgaacgag agcctgatcg acctgcaaga actgggcaag tacgagcagt acatcaagtg    15060

gccctggtac atctggctgg gctttatcgc cggactgatt gccatcgtga tggtcacaat    15120

catgctgtgt tgcatgacca gctgctgtag ctgcctgaag ggctgttgta gctgtggctc    15180

ctgctgcaag ttcgacgagg acgattctga gcccgtgctg aagggcgtga aactgcacta    15240

cacctgataa gcggccgctc gagcatgcat ctagagggcc ctattctata gtgtcaccta    15300

aatgctagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt    15360

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa    15420

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg    15480

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg    15540

gtgggctcta tggcttctga ggcggaaaga accagctggg gctcgagggg ggatcgatcc    15600

gtcgagatat ctagacccag ctttcttgta caaagtggtg atcgattcga cagatcgcga    15660

tcgcagtgag tagtgttctg gggcggggga ggacctgcat gagggccaga atgactgaaa    15720

tctgtgcttt tctgtgtgtt gcagcatcat gagcggaagc ggctcctttg agggaggggt    15780

attcagccct tatctgacgg ggcgtctccc ctcctgggcg ggagtgcgtc agaatgtgat    15840

gggatccacg gtggacggcc ggcccgtgca gcccgcgaac tcttcaaccc tgacctatgc    15900

aaccctgagc tcttcgtcgg tggacgcagc tgccgccgca gctgctgcat ccgccgccag    15960

cgccgtgcgc ggaatggcca tgggcgccgg ctactacggc actctggtgg ccaactcgag    16020

ttccaccaat aatcccgcca gcctgaacga ggagaagctg ctgctgctga tggcccagct    16080

tgaggccttg acccagcgcc tgggcgagct gacccagcag gtggctcagc tgcaggagca    16140

gacgcgggcc gcggttgcca cggtgaaatc caaataaaaa atgaatcaat aaataaacgg    16200

agacggttgt tgattttaac acagagtctg aatctttatt tgatttttcg cgcgcggtag    16260

gccctggacc accggtctcg atcattgagc acccggtgga tcttttccag gacccggtag    16320

aggtgggctt ggatgttgag gtacatgggc atgagcccgt cccgggggtg gaggtagctc    16380

cattgcaggg cctcgtgctc gggggtggtg ttgtaaatca cccagtcata gcaggggcgc    16440

agggcgtggt gttgcacaat atctttgagg aggagactga tggccacggg cagccctttg    16500

gtgtaggtgt ttacaaatct gttgagctgg gagggatgca tgcgggggga gatgaggtgc    16560

atcttggcct ggatcttgag attggcgatg ttaccgccca gatcccgcct ggggttcatg    16620

ttgtgcagga ccaccagcac ggtgtatccg gtgcacttgg ggaatttatc atgcaacttg    16680

gaagggaagg cgtgaaagaa tttggcgacg cccttgtgtc cgcccaggtt ttccatgcac    16740

tcatccatga tgatggcaat gggcccgtgg gcggcggcct gggcaaagac gtttcggggg    16800

tcggacacat catagttgtg gtcctgggtg aggtcatcat aggccatttt aatgaatttg    16860

gggcggaggg tgccggactg ggggacaaag gtaccctcga tcccgggggc gtagttcccc    16920

tcacagatct gcatctccca ggctttgagc tcagaggggg ggatcatgtc cacctgcggg    16980

gcgataaaga acacggtttc cggggcgggg gagatgagct gggccgaaag caagttccgg    17040

agcagctggg acttgccgca gccggtgggg ccgtaaatga ccccgatgac cggctgcagg    17100

tggtagttga gggagagaca gctgccgtcc tcccggagga ggggggccac ctcgttcatc    17160

atctcgcgca cgtgcatgtt ctcgcgcacc agttccgcca ggaggcgctc tccccccaga    17220

gataggagct cctggagcga ggcgaagttt ttcagcggct tgagtccgtc ggccatgggc    17280

attttggaga gggtctgttg caagagttcc aagcggtccc agagctcggt gatgtgctct    17340

acggcatctc gatccagcag acctcctcgt ttcgcgggtt gggacgactg cgggagtagg    17400

gcaccagacg atgggcgtcc agcgcagcca gggtccggtc cttccagggc cgcagcgtcc    17460

gcgtcagggt ggtctccgtc acggtgaagg ggtgcgcgcc gggctgggcg cttgcgaggg    17520

tgcgcttcag gctcatccgg ctggtcgaaa accgctcccg atcggcgccc tgcgcgtcgg    17580

ccaggtagca attgaccatg agttcgtagt tgagcgcctc ggccgcgtgg cctttggcgc    17640

ggagcttacc tttggaagtc tgcccgcagg cgggacagag gagggacttg agggcgtaga    17700

gcttgggggc gaggaagacg gaatcggggg cgtaggcgtc cgcgccgcag tgggcgcaga    17760

cggtctcgca ctccacgagc caggtgaggt cgggctggtc ggggtcaaaa accagtttcc    17820

cgccgttctt tttgatgcgt ttcttacctt tggtctccat gagctcgtgt ccccgctggg    17880

tgacaaagag gctgtccgtg tccccgtaga ccgactttat gggccggtcc tcgagcggtg    17940

tgccgcggtc ctcctcgtag aggaaccccg cccactccga gacgaaagcc cgggtccagg    18000

ccagcacgaa ggaggccacg tgggacgggt agcggtcgtt gtccaccagc gggtccactt    18060

tttccagggt atgcaaacac atgtccccct cgtccacatc caggaaggtg attggcttgt    18120

aagtgtaggc cacgtgaccg ggggtcccgg ccgggggggt ataaaagggg gcgggcccct    18180

gctcgtcctc actgtcttcc ggatcgctgt ccaggagcgc cagctgttgg ggtaggtatt    18240

ccctctcgaa ggcgggcatg acctcggcac tcaggttgtc agtttctaga aacgaggagg    18300

atttgatatt gacggtgcca gcggagatgc ctttcaagag cccctcgtcc atctggtcag    18360

aaaagacgat ttttttgttg tcgagcttgg tggcgaagga gccgtagagg gcgttggaaa    18420

ggagcttggc gatggagcgc atggtctggt ttttttcctt gtcggcgcgc tccttggccg    18480

cgatgttgag ctgcacgtac tcgcgcgcca cgcacttcca ttcggggaag acggtggtca    18540

tctcgtcggg cacgattctg acctgccaac ctcgattatg cagggtgatg aggtccacac    18600

tggtggccac ctcgccgcgc aggggctcgt tggtccagca gaggcggccg cccttgcgcg    18660

agcagaaggg gggcagaggg tccagcatga cctcgtcggg ggggtcggca tcgatggtga    18720

agatgccggg caggagatcg gggtcgaagt agctgatgga agtggccaga tcgtccaggg    18780

aagcttgcca ttcgcgcacg gccagcgcgc gctcgtaggg actgaggggc gtgccccagg    18840

gcatggggtg ggtgagcgcg gaggcgtaca tgccgcagat gtcgtagacg tagaggggct    18900

cctcgaggat gccgatgtag gtggggtagc agcgcccccc gcggatgctg gcgcgcacgt    18960

agtcatacag ctcgtgcgag ggcgcgagga gccccgggcc caggttggtg cgactgggct    19020

tttcggcgcg gtagacgatc tggcgaaaga tggcatgcga gttggaggag atggtgggcc    19080

tttggaagat gttgaagtgg gcgtggggga ggccgaccga gtcgcggatg aagtgggcgt    19140

aggagtcttg cagtttggcg acgagctcgg cggtgacgag gacgtccaga gcgcagtagt    19200

cgagggtctc ctggatgatg tcatacttga gctggccctt ttgtttccac agctcgcggt    19260

tgagaaggaa ctcttcgcgg tccttccagt actcttcgag ggggaacccg tcctgatctg    19320

cacggtaaga gcctagcatg tagaactggt tgacggcctt gtaggcgcag cagcccttct    19380

ccacggggag ggcgtaggcc tgggcggcct tgcgcaggga ggtgtgcgtg agggcgaagg    19440

tgtccctgac catgaccttg aggaactggt gcttgaaatc gatatcgtcg cagcccccct    19500

gctcccagag ctggaagtcc gtgcgcttct tgtaggcggg gttgggcaaa gcgaaagtaa    19560

catcgttgaa aaggatcttg cccgcgcggg gcataaagtt gcgagtgatg cggaaaggct    19620

ggggcacctc ggcccggttg ttgatgacct gggcggcgag cacgatctcg tcgaaaccgt    19680

tgatgttgtg gcccacgatg tagagttcca cgaatcgcgg gcggcccttg acgtggggca    19740

gcttcttgag ctcctcgtag gtgagctcgt cggggtcgct gagaccgtgc tgctcgagcg    19800

cccagtcggc gagatggggg ttggcgcgga ggaaggaagt ccagagatcc acggccaggg    19860

cggtttgcag acggtcccgg tactgacgga actgctgccc gacggccatt ttttcggggg    19920

tgacgcagta gaaggtgcgg gggtccccgt gccagcggtc ccatttgagc tggagggcga    19980

gatcgagggc gagctcgacg aggcggtcgt cccctgagag tttcatgacc agcatgaagg    20040

ggacgagctg cttgccgaag gaccccatcc aggtgtaggt ttccacatcg taggtgagga    20100

agagcctttc ggtgcgagga tgcgagccga tggggaagaa ctggatctcc tgccaccaat    20160

tggaggaatg gctgttgatg tgatggaagt agaaatgccg acggcgcgcc gaacactcgt    20220

gcttgtgttt atacaagcgg ccacagtgct cgcaacgctg cacgggatgc acgtgctgca    20280

cgagctgtac ctgagttcct ttgacgagga atttcagtgg gaagtggagt cgtggcgcct    20340

gcatctcgtg ctgtactacg tcgtggtggt cggcctggcc ctcttctgcc tcgatggtgg    20400

tcatgctgac gagcccgcgc gggaggcagg tccagacctc ggcgcgagcg ggtcggagag    20460

cgaggacgag ggcgcgcagg ccggagctgt ccagggtcct gagacgctgc ggagtcaggt    20520

cagtgggcag cggcggcgcg cggttgactt gcaggagttt ttccagggcg cgcgggaggt    20580

ccagatggta cttgatctcc accgcgccgt tggtggcgac gtcgatggct tgcagggtcc    20640

cgtgcccctg gggtgtgacc accgtccccc gtttcttctt gggcggctgg ggcgacgggg    20700

gcggtgcctc ttccatggtt agaagcggcg gcgaggacgc gcgccgggcg gcagaggcgg    20760

ctcggggccc ggaggcaggg gcggcagggg cacgtcggcg ccgcgcgcgg gtaggttctg    20820

gtactgcgcc cggagaagac tggcgtgagc gacgacgcga cggttgacgt cctggatctg    20880

acgcctctgg gtgaaggcca cgggacccgt gagtttgaac ctgaaagaga gttcgacaga    20940

atcaatctcg gtatcgttga cggcggcctg ccgcaggatc tcttgcacgt cgcccgagtt    21000

gtcctggtag gcgatctcgg tcatgaactg ctcgatctcc tcctcctgaa ggtctccgcg    21060

accggcgcgc tccacggtgg ccgcgaggtc gttggagatg cggcccatga gctgcgagaa    21120

ggcgttcatg cccgcctcgt tccagacgcg gctgtagacc acgacgccct cgggatcgcg    21180

ggcgcgcatg accacctggg cgaggttgag ctccacgtgg cgcgtgaaga ccgcgtagtt    21240

gcagaggcgc tggtagaggt agttgagcgt ggtggcgatg tgctcggtga cgaagaaata    21300

catgatccag cggcggagcg gcatctcgct gacgtcgccc agcgcctcca agcgttccat    21360

ggcctcgtaa aagtccacgg cgaagttgaa aaactgggag ttgcgcgccg agacggtcaa    21420

ctcctcctcc agaagacgga tgagctcggc gatggtggcg cgcacctcgc gctcgaaggc    21480

ccccgggagt tcctccactt cctcctcttc ttcctcctcc actaacatct cttctacttc    21540

ctcctcaggc ggtggtggtg gcgggggagg gggcctgcgt cgccggcggc gcacgggcag    21600

acggtcgatg aagcgctcga tggtctcgcc gcgccggcgt cgcatggtct cggtgacggc    21660

gcgcccgtcc tcgcggggcc gcagcgtgaa gacgccgccg cgcatctcca ggtggccggg    21720

ggggtccccg ttgggcaggg agagggcgct gacgatgcat cttatcaatt gccccgtagg    21780

gactccgcgc aaggacctga gcgtctcgag atccacggga tctgaaaacc gttgaacgaa    21840

ggcttcgagc cagtcgcagt cgcaaggtag gctgagcacg gtttcttctg ccgggtcatg    21900

ttggggagcg gggcgggcga tgctgctggt gatgaagttg aaataggcgg ttctgagacg    21960

gcggatggtg gcgaggagca ccaggtcttt gggcccggct tgctggatgc gcagacggtc    22020

ggccatgccc caggcgtggt cctgacacct ggccaggtcc ttgtagtagt cctgcatgag    22080

ccgctccacg ggcacctcct cctcgcccgc gcggccgtgc atgcgcgtga gcccgaagcc    22140

gcgctggggc tggacgagcg ccaggtcggc gacgacgcgc tcggcgagga tggcctgctg    22200

gatctgggtg agggtggtct ggaagtcgtc aaagtcgacg aagcggtggt aggctccggt    22260

gttgatggtg taggagcagt tggccatgac ggaccagttg acggtctggt ggcccggacg    22320

cacgagctcg tggtacttga ggcgcgagta ggcgcgcgtg tcgaagatgt agtcgttgca    22380

ggtgcgcacc aggtactggt agccgatgag gaagtgcggc ggcggctggc ggtagagcgg    22440

ccatcgctcg gtggcggggg cgccgggcgc gaggtcctcg agcatggtgc ggtggtagcc    22500

gtagatgtac ctggacatcc aggtgatgcc ggcggcggtg gtggaggcgc gcgggaactc    22560

gcggacgcgg ttccagatgt tgcgcagcgg caggaagtag ttcatggtgg gcacggtctg    22620

gcccgtgagg cgcgcgcagt cgtggatgct ctatacgggc aaaaacgaaa gcggtcagcg    22680

gctcgactcc gtggcctgga ggctaagcga acgggttggg ctgcgcgtgt accccggttc    22740

gaatctcgaa tcaggctgga gccgcagcta acgtggtact ggcactcccg tctcgaccca    22800

agcctgcacc aaccctccag gatacggagg cgggtcgttt tgcaactttt tttggaggcc    22860

ggaaatgaaa ctagtaagcg cggaaagcgg ccgaccgcga tggctcgctg ccgtagtctg    22920

gagaagaatc gccagggttg cgttgcggtg tgccccggtt cgaggccggc cggattccgc    22980

ggctaacgag ggcgtggctg ccccgtcgtt tccaagaccc catagccagc cgacttctcc    23040

agttacggag cgagcccctc ttttgttttg tttgtttttg ccagatgcat cccgtactgc    23100

ggcagatgcg cccccaccac cctccaccgc aacaacagcc ccctcctcca cagccggcgc    23160

ttctgccccc gccccagcag cagcagcaac ttccagccac gaccgccgcg gccgccgtga    23220

gcggggctgg acagacttct cagtatgatc acctggcctt ggaagagggc gaggggctgg    23280

cgcgcctggg ggcgtcgtcg ccggagcggc acccgcgcgt gcagatgaaa agggacgctc    23340

gcgaggccta cgtgcccaag cagaacctgt tcagagacag gagcggcgag gagcccgagg    23400

agatgcgcgc ggcccggttc cacgcggggc gggagctgcg gcgcggcctg gaccgaaaga    23460

gggtgctgag ggacgaggat ttcgaggcgg acgagctgac ggggatcagc cccgcgcgcg    23520

cgcacgtggc cgcggccaac ctggtcacgg cgtacgagca gaccgtgaag gaggagagca    23580

acttccaaaa atccttcaac aaccacgtgc gcaccctgat cgcgcgcgag gaggtgaccc    23640

tgggcctgat gcacctgtgg gacctgctgg aggccatcgt gcagaacccc accagcaagc    23700

cgctgacggc gcagctgttc ctggtggtgc agcatagtcg ggacaacgag gcgttcaggg    23760

aggcgctgct gaatatcacc gagcccgagg gccgctggct cctggacctg gtgaacattc    23820

tgcagagcat cgtggtgcag gagcgcgggc tgccgctgtc cgagaagctg gcggccatca    23880

acttctcggt gctgagtctg ggcaagtact acgctaggaa gatctacaag accccgtacg    23940

tgcccataga caaggaggtg aagatcgacg ggttttacat gcgcatgacc ctgaaagtgc    24000

tgaccctgag cgacgatctg ggggtgtacc gcaacgacag gatgcaccgc gcggtgagcg    24060

ccagcaggcg gcgcgagctg agcgaccagg agctgatgca cagcctgcag cgggccctga    24120

ccggggccgg gaccgagggg gagagctact ttgacatggg cgcggacctg cactggcagc    24180

ccagccgccg ggccttggag gcggcaggcg gtccccccta catagaagag gtggacgatg    24240

aggtggacga ggagggcgag tacctggaag actgatggcg cgaccgtatt tttgctagat    24300

gcaacaacag ccacctcctg atcccgcgat gcgggcggcg ctgcagagcc agccgtccgg    24360

cattaactcc tcggacgatt ggacccaggc catgcaacgc atcatggcgc tgacgacccg    24420

caaccccgaa gcctttagac agcagcccca ggccaaccgg ctctcggcca tcctggaggc    24480

cgtggtgccc tcgcgctcca accccacgca cgagaaggtc ctggccatcg tgaacgcgct    24540

ggtggagaac aaggccatcc gcggcgacga ggccggcctg gtgtacaacg cgctgctgga    24600

gcgcgtggcc cgctacaaca gcaccaacgt gcagaccaac ctggaccgca tggtgaccga    24660

cgtgcgcgag gccgtggccc agcgcgagcg gttccaccgc gagtccaacc tgggatccat    24720

ggtggcgctg aacgccttcc tcagcaccca gcccgccaac gtgccccggg gccaggagga    24780

ctacaccaac ttcatcagcg ccctgcgcct gatggtgacc gaggtgcccc agagcgaggt    24840

gtaccagtcc gggccggact acttcttcca gaccagtcgc cagggcttgc agaccgtgaa    24900

cctgagccag gcgttcaaga acttgcaggg cctgtggggc gtgcaggccc cggtcgggga    24960

ccgcgcgacg gtgtcgagcc tgctgacgcc gaactcgcgc ctgctgctgc tgctggtggc    25020

ccccttcacg gacagcggca gcatcaaccg caactcgtac ctgggctacc tgattaacct    25080

gtaccgcgag gccatcggcc aggcgcacgt ggacgagcag acctaccagg agatcaccca    25140

cgtgagccgc gccctgggcc aggacgaccc gggcaatctg gaagccaccc tgaacttttt    25200

gctgaccaac cggtcgcaga agatcccgcc ccagtacacg ctcagcgccg aggaggagcg    25260

catcctgcga tacgtgcagc agagcgtggg cctgttcctg atgcaggagg gggccacccc    25320

cagcgccgcg ctcgacatga ccgcgcgcaa catggagccc agcatgtacg ccagcaaccg    25380

cccgttcatc aataaactga tggactactt gcatcgggcg gccgccatga actctgacta    25440

tttcaccaac gccatcctga atccccactg gctcccgccg ccggggttct acacgggcga    25500

gtacgacatg cccgacccca atgacgggtt cctgtgggac gatgtggaca gcagcgtgtt    25560

ctccccccga ccgggtgcta acgagcgccc cttgtggaag aaggaaggca gcgaccgacg    25620

cccgtcctcg gcgctgtccg gccgcgaggg tgctgccgcg gcggtgcccg aggccgccag    25680

tcctttcccg agcttgccct tctcgctgaa cagtattcgc agcagcgagc tgggcaggat    25740

cacgcgcccg cgcttgctgg gcgaggagga gtacttgaat gactcgctgt tgagacccga    25800

gcgggagaag aacttcccca ataacgggat agagagcctg gtggacaaga tgagccgctg    25860

gaagacgtat gcgcaggagc acagggacga tccgtcgcag ggggccacga gccggggcag    25920

cgccgcccgt aaacgccggt ggcacgacag gcagcgggga ctgatgtggg acgatgagga    25980

ttccgccgac gacagcagcg tgttggactt gggtgggagt ggtaacccgt tcgctcacct    26040

gcgcccccgc atcgggcgca tgatgtaaga gaaaccgaaa ataaatgata ctcaccaagg    26100

ccatggcgac cagcgtgcgt tcgtttcttc tctgttgttg tatctagtat gatgaggcgt    26160

gcgtacccgg agggtcctcc tccctcgtac gagagcgtga tgcagcaggc gatggcggcg    26220

gcggcggcga tgcagccccc gctggaggct ccttacgtgc ccccgcggta cctggcgcct    26280

acggaggggc ggaacagcat tcgttactcg gagctggcac ccttgtacga taccacccgg    26340

ttgtacctgg tggacaacaa gtcggcggac atcgcctcgc tgaactacca gaacgaccac    26400

agcaacttcc tgaccaccgt ggtgcagaac aatgacttca cccccacgga ggccagcacc    26460

cagaccatca actttgacga gcgctcgcgg tggggcggtc agctgaaaac catcatgcac    26520

accaacatgc ccaacgtgaa cgagttcatg tacagcaaca agttcaaggc gcgggtgatg    26580

gtctcccgca agacccccaa cggggtgaca gtgacagatg gtagtcagga tatcttggag    26640

tatgaatggg tggagtttga gctgcccgaa ggcaacttct cggtgaccat gaccatcgac    26700

ctgatgaaca acgccatcat cgacaattac ttggcggtgg ggcggcagaa cggggtcctg    26760

gagagcgata tcggcgtgaa gttcgacact aggaacttca ggctgggctg ggaccccgtg    26820

accgagctgg tcatgcccgg ggtgtacacc aacgaggcct tccaccccga tattgtcttg    26880

ctgcccggct gcggggtgga cttcaccgag agccgcctca gcaacctgct gggcattcgc    26940

aagaggcagc ccttccagga gggcttccag atcatgtacg aggatctgga ggggggcaac    27000

atccccgcgc tcctggatgt cgacgcctat gagaaaagca aggaggagag cgccgccgcg    27060

gcgactgcag ctgtagccac cgcctctacc gaggtcaggg gcgataattt tgccagccct    27120

gcagcagtgg cagcggccga ggcggctgaa accgaaagta agatagtcat tcagccggtg    27180

gagaaggata gcaaggacag gagctacaac gtgctgccgg acaagataaa caccgcctac    27240

cgcagctggt acctggccta caactatggc gaccccgaga agggcgtgcg ctcctggacg    27300

ctgctcacca cctcggacgt cacctgcggc gtggagcaag tctactggtc gctgcccgac    27360

atgatgcaag acccggtcac cttccgctcc acgcgtcaag ttagcaacta cccggtggtg    27420

ggcgccgagc tcctgcccgt ctactccaag agcttcttca acgagcaggc cgtctactcg    27480

cagcagctgc gcgccttcac ctcgctcacg cacgtcttca accgcttccc cgagaaccag    27540

atcctcgtcc gcccgcccgc gcccaccatt accaccgtca gtgaaaacgt tcctgctctc    27600

acagatcacg ggaccctgcc gctgcgcagc agtatccggg gagtccagcg cgtgaccgtt    27660

actgacgcca gacgccgcac ctgcccctac gtctacaagg ccctgggcat agtcgcgccg    27720

cgcgtcctct cgagccgcac cttctaaaaa atgtccattc tcatctcgcc cagtaataac    27780

accggttggg gcctgcgcgc gcccagcaag atgtacggag gcgctcgcca acgctccacg    27840

caacaccccg tgcgcgtgcg cgggcacttc cgcgctccct ggggcgccct caagggccgc    27900

gtgcggtcgc gcaccaccgt cgacgacgtg atcgaccagg tggtggccga cgcgcgcaac    27960

tacacccccg ccgccgcgcc cgtctccacc gtggacgccg tcatcgacag cgtggtggcc    28020

gacgcgcgcc ggtacgcccg cgccaagagc cggcggcggc gcatcgcccg gcggcaccgg    28080

agcacccccg ccatgcgcgc ggcgcgagcc ttgctgcgca gggccaggcg cacgggacgc    28140

agggccatgc tcagggcggc cagacgcgcg gcttcaggcg ccagcgccgg caggacccgg    28200

agacgcgcgg ccacggcggc ggcagcggcc atcgccagca tgtcccgccc gcggcgaggg    28260

aacgtgtact gggtgcgcga cgccgccacc ggtgtgcgcg tgcccgtgcg cacccgcccc    28320

cctcgcactt gaagatgttc acttcgcgat gttgatgtgt cccagcggcg aggaggatgt    28380

ccaagcgcaa attcaaggaa gagatgctcc aggtcatcgc gcctgagatc tacggccccg    28440

cggtggtgaa ggaggaaaga aagccccgca aaatcaagcg ggtcaaaaag gacaaaaagg    28500

aagaagatga cgatctggtg gagtttgtgc gcgagttcgc cccccggcgg cgcgtgcagt    28560

ggcgcgggcg gaaagtgcac ccggtgctga gacccggcac caccgtggtc ttcacgcccg    28620

gcgagcgctc cggcagcgct tccaagcgct cctacgacga ggtgtacggg gacgaggaca    28680

tcctcgagca ggcggccgag cgcctgggcg agtttgctta cggcaagcgc agccgccccg    28740

ccctgaagga agaggcggtg tccatcccgc tggaccacgg caaccccacg ccgagcctca    28800

agcccgtgac cctgcagcag gtgctgccga gcgcagcgcc gcgccggggg ttcaagcgcg    28860

agggcgagga tctgtacccc accatgcagc tgatggtgcc caagcgccag aagctggaag    28920

acgtgctgga gaccatgaag gtggacccgg acgtgcagcc cgaggtcaag gtgcggccca    28980

tcaagcaggt ggccccgggc ctgggcgtgc agaccgtgga catcaagatc cccacggagc    29040

ccatggaaac gcagaccgag cccatgatca agcccagcac cagcaccatg gaggtgcaga    29100

cggatccctg gatgccatcg gctcctagcc gaagaccccg gcgcaagtac ggcgcggcca    29160

gcctgctgat gcccaactac gcgctgcatc cttccatcat ccccacgccg ggctaccgcg    29220

gcacgcgctt ctaccgcggt catacaacca gccgccgccg caagaccacc acccgccgcc    29280

gccgtcgccg cacagccgct gcatctaccc ctgccgccct ggtgcggaga gtgtaccgcc    29340

gcggccgcgc gcctctgacc ctaccgcgcg cgcgctacca cccgagcatc gccatttaaa    29400

ctttcgcctg ctttgcagat ggccctcaca tgccgcctcc gcgttcccat tacgggctac    29460

cgaggaagaa aaccgcgccg tagaaggctg gcggggaacg ggatgcgtcg ccaccaccat    29520

cggcggcggc gcgccatcag caagcggttg gggggaggct tcctgcccgc gctgatcccc    29580

atcatcgccg cggcgatcgg ggcgatcccc ggcattgctt ccgtggcggt gcaggcctct    29640

cagcgccact gagacacttg gaaaacatct tgtaataaac caatggactc tgacgctcct    29700

ggtcctgtga tgtgttttcg tagacagatg gaagacatca atttttcgtc cctggctccg    29760

cgacacggca cgcggccgtt catgggcacc tggagcgaca tcggcaccag ccaactgaac    29820

gggggcgcct tcaattggag cagtctctgg agcgggctta agaatttcgg gtccacgctt    29880

aaaacctatg gcagcaaggc gtggaacagc accacagggc aggcgctgag ggataagctg    29940

aaagagcaga acttccagca gaaggtggtc gatgggctcg cctcgggcat caacggggtg    30000

gtggacctgg ccaaccaggc cgtgcagcgg cagatcaaca gccgcctgga cccggtgccg    30060

cccgccggct ccgtggagat gccgcaggtg gaggaggagc tgcctcccct ggacaagcgg    30120

ggcgagaagc gaccccgccc cgacgcggag gagacgctgc tgacgcacac ggacgagccg    30180

cccccgtacg aggaggcggt gaaactgggt ctgcccacca cgcggcccat cgcgcccctg    30240

gccaccgggg tgctgaaacc cgaaagtaat aagcccgcga ccctggactt gcctcctccc    30300

gcttcccgcc cctctacagt ggctaagccc ctgccgccgg tggccgtggc ccgcgcgcga    30360

cccgggggct ccgcccgccc tcatgcgaac tggcagagca ctctgaacag catcgtgggt    30420

ctgggagtgc agagtgtgaa gcgccgccgc tgctattaaa cctaccgtag cgcttaactt    30480

gcttgtctgt gtgtgtatgt attatgtcgc cgctgtccgc cagaaggagg agtgaagagg    30540

cgcgtcgccg agttgcaaga tggccacccc atcgatgctg ccccagtggg cgtacatgca    30600

catcgccgga caggacgctt cggagtacct gagtccgggt ctggtgcagt tcgcccgcgc    30660

cacagacacc tacttcagtc tggggaacaa gtttaggaac cccacggtgg cgcccacgca    30720

cgatgtgacc accgaccgca gccagcggct gacgctgcgc ttcgtgcccg tggaccgcga    30780

ggacaacacc tactcgtaca aagtgcgcta cacgctggcc gtgggcgaca accgcgtgct    30840

ggacatggcc agcacctact ttgacatccg cggcgtgctg gatcggggcc ctagcttcaa    30900

accctactcc ggcaccgcct acaacagcct ggctcccaag ggagcgccca attccagcca    30960

gtgggagcaa aaaaaggcag gcaatggtga cactatggaa acacacacat ttggtgtggc    31020

cccaatgggc ggtgagaata ttacaatcga cggattacaa attggaactg acgctacagc    31080

tgatcaggat aaaccaattt atgctgacaa aacattccag cctgaacctc aagtaggaga    31140

agaaaattgg caagaaactg aaagctttta tggcggtagg gctcttaaaa aagacacaag    31200

catgaaacct tgctatggct cctatgctag acccaccaat gtaaagggag gtcaagctaa    31260

acttaaagtt ggagctgatg gagttcctac caaagaattt gacatagacc tggctttctt    31320

tgatactccc ggtggcacag tgaatggaca agatgagtat aaagcagaca ttgtcatgta    31380

taccgaaaac acgtatctgg aaactccaga cacgcatgtg gtatacaaac caggcaagga    31440

tgatgcaagt tctgaaatta acctggttca gcagtccatg cccaatagac ccaactatat    31500

tgggttcaga gacaacttta ttgggctcat gtattacaac agtactggca atatgggggt    31560

gctggctggt caggcctcac agctgaatgc tgtggtcgac ttgcaagaca gaaacaccga    31620

gctgtcatac cagctcttgc ttgactcttt gggtgacaga acccggtatt tcagtatgtg    31680

gaatcaggcg gtggacagtt atgatcctga tgtgcgcatt attgaaaacc atggtgtgga    31740

agacgaactt cccaactatt gcttccccct ggatgggtct ggcactaatg ccgcttacca    31800

aggtgtgaaa gtaaaaaatg gtaacgatgg tgatgttgag agcgaatggg aaaatgatga    31860

tactgtcgca gctcgaaatc aattatgcaa gggcaacatt tttgccatgg aaattaacct    31920

ccaagccaac ctgtggagaa gtttcctcta ctcgaacgtg gccctgtacc tgcccgactc    31980

ttacaagtac acgccagcca acatcaccct gcccaccaac accaacactt atgattacat    32040

gaacgggaga gtggtgcctc cctcgctggt ggacgcctac atcaacatcg gggcgcgctg    32100

gtcgctggac cccatggaca acgtcaatcc cttcaaccac caccgcaacg cgggcctgcg    32160

ctaccgctcc atgctcctgg gcaacgggcg ctacgtgccc ttccacatcc aggtgcccca    32220

gaaatttttc gccatcaaga gcctcctgct cctgcccggg tcctacacct acgagtggaa    32280

cttccgcaag gacgtcaaca tgatcctgca gagctccctc ggcaacgacc tgcgcacgga    32340

cggggcctcc atctccttca ccagcatcaa cctctacgcc accttcttcc ccatggcgca    32400

caacacggcc tccacgctcg aggccatgct gcgcaacgac accaacgacc agtccttcaa    32460

cgactacctc tcggcggcca acatgctcta ccccatcccg gccaacgcca ccaacgtgcc    32520

catctccatc ccctcgcgca actgggccgc cttccgcggc tggtccttca cgcgcctcaa    32580

gaccaaggag acgccctcgc tgggctccgg gttcgacccc tacttcgtct actcgggctc    32640

catcccctac ctcgacggca ccttctacct caaccacacc ttcaagaagg tctccatcac    32700

cttcgactcc tccgtcagct ggcccggcaa cgaccggctc ctgacgccca acgagttcga    32760

aatcaagcgc accgtcgacg gcgagggata caacgtggcc cagtgcaaca tgaccaagga    32820

ctggttcctg gtccagatgc tggcccacta caacatcggc taccagggct tctacgtgcc    32880

cgagggctac aaggaccgca tgtactcctt cttccgcaac ttccagccca tgagccgcca    32940

ggtggtggac gaggtcaact acaaggacta ccaggccgtc accctggcct accagcacaa    33000

caactcgggc ttcgtcggct acctcgcgcc caccatgcgc cagggccagc cctaccccgc    33060

caactacccg tacccgctca tcggcaagag cgccgtcacc agcgtcaccc agaaaaagtt    33120

cctctgcgac agggtcatgt ggcgcatccc cttctccagc aacttcatgt ccatgggcgc    33180

gctcaccgac ctcggccaga acatgctcta tgccaactcc gcccacgcgc tagacatgaa    33240

tttcgaagtc gaccccatgg atgagtccac ccttctctat gttgtcttcg aagtcttcga    33300

cgtcgtccga gtgcaccagc cccaccgcgg cgtcatcgag gccgtctacc tgcgcacccc    33360

cttctcggcc ggtaacgcca ccacctaaat tgctacttgc atgatggctg agcccacagg    33420

ctccggcgag caggagctca gggccatcat ccgcgacctg ggctgcgggc cctacttcct    33480

gggcaccttc gataagcgct tcccgggatt catggccccg cacaagctgg cctgcgccat    33540

cgtcaacacg gccggccgcg agaccggggg cgagcactgg ctggccttcg cctggaaccc    33600

gcgctcgaac acctgctacc tcttcgaccc cttcgggttc tcggacgagc gcctcaagca    33660

gatctaccag ttcgagtacg agggcctgct gcgccgtagc gccctggcca ccgaggaccg    33720

ctgcgtcacc ctggaaaagt ccacccagac cgtgcagggt ccgcgctcgg ccgcctgcgg    33780

gctcttctgc tgcatgttcc tgcacgcctt cgtgcactgg cccgaccgcc ccatggacaa    33840

gaaccccacc atgaacttgc tgacgggggt gcccaacggc atgctccagt cgccccaggt    33900

ggaacccacc ctgcgccgca accaggaggc gctctaccgc ttcctcaact cccactccgc    33960

ctactttcgc tcccaccgcg cgcgcatcga gaaggccacc gccttcgacc gcatgaacaa    34020

tcaagacatg taaaccgtgt gtgtatgttt aaaatatctt ttaataaaca gcactttaat    34080

gttacacatg catctgagat gattttattt tagaaatcga aagggttctg ccgggtctcg    34140

gcatggcccg cgggcaggga cacgttgcgg aactggtact tggccagcca cttgaactcg    34200

gggatcagca gtttgggcag cggggtgtcg gggaaggagt cggtccacag cttccgcgtc    34260

agctgcaggg cgcccagcag gtcgggcgcg gagatcttga aatcgcagtt gggacccgcg    34320

ttctgcgcgc gagagttgcg gtacacgggg ttgcagcact ggaacaccat cagggccggg    34380

tgcttcacgc tcgccagcac cgccgcgtcg gtgatgctct ccacgtcgag gtcctcggcg    34440

ttggccatcc cgaagggggt catcttgcag gtctgccttc ccatggtggg cacgcacccg    34500

ggcttgtggt tgcaatcgca gtgcaggggg atcagcatca tctgggcctg gtcggcgttc    34560

atccccgggt acatggcctt catgaaagcc tccaattgcc tgaacgcctg ctgggccttg    34620

gctccctcgg tgaagaagac cccgcaggac ttgctagaga actggttggt ggcacagccg    34680

gcatcgtgca cgcagcagcg cgcgtcgttg ttggccagct gcaccacgct gcgcccccag    34740

cggttctggg tgatcttggc ccggtcgggg ttctccttca gcgcgcgctg cccgttctcg    34800

ctcgccacat ccatctcgat catgtgctcc ttctggatca tggtggtccc gtgcaggcac    34860

cgcagtttgc cctcggcctc ggtgcacccg tgcagccaca gcgcgcaccc ggtgcactcc    34920

cagttcttgt gggcgatctg ggaatgcgcg tgcacgaacc cttgcaggaa gcggcccatc    34980

atggtcgtca gggtcttgtt gctagtgaag gtcaacggga tgccgcggtg ctcctcgttg    35040

atgtacaggt ggcagatgcg gcggtacacc tcgccctgct cgggcatcag ttggaagttg    35100

gctttcaggt cggtctccac gcggtagcgg tccatcagca tagtcatgat ttccatgccc    35160

ttctcccagg ccgagacgat gggcaggctc atagggttct tcaccatcat cttagcacta    35220

gcagccgcgg ccagggggtc gctctcatcc agggtctcaa agctccgctt gccgtccttc    35280

tcggtgatcc gcaccggggg gtagctgaag cccacggccg ccagctcctc ctcggcctgt    35340

ctttcgtcct cgctgtcctg gctgacgtcc tgcatgacca catgcttggt cttgcggggt    35400

ttcttcttgg gcggcagtgg cggcggagat gcttgtggcg agggggagcg cgagttctcg    35460

ctcaccacta ctatctcttc ctcttcttgg tccgaggcca cgcggcggta ggtatgtctc    35520

ttcgggggca gaggcggagg cgacgggctc tcgccgccgc gacttggcgg atggctggca    35580

gagccccttc cgcgttcggg ggtgcgctcc cggcggcgct ctgactgact tcctccgcgg    35640

ccggccattg tgttctccta gggaggaaca acaagcatgg agactcagcc atcgccaacc    35700

tcgccatctg cccccaccgc cggcgacgag aagcagcagc agcagaatga aagcttaacc    35760

gccccgccgc ccagccccgc ctccgacgca gccgcggtcc cagacatgca agagatggag    35820

gaatccatcg agattgacct gggctatgtg acgcccgcgg agcatgagga ggagctggca    35880

gtgcgctttc aatcgtcaag ccaggaagat aaagaacagc cagagcagga agcagagaac    35940

gagcagagtc aggctgggct cgagcatggc gactacctcc acctgagcgg ggaggaggac    36000

gcgctcatca agcatctggc ccggcaggcc accatcgtca aggacgcgct gctcgaccgc    36060

accgaggtgc ccctcagcgt ggaggagctc agccgcgcct acgagctcaa cctcttctcg    36120

ccgcgcgtgc cccccaagcg ccagcccaac ggcacctgcg agcccaaccc ccgcctcaac    36180

ttctacccgg tcttcgcggt gcccgaggcc ctggccacct accacatctt tttcaagaac    36240

caaaagatcc ccgtctcctg ccgcgccaac cgcacccgcg ccgacgccct cttcaacctg    36300

ggtcccggcg cccgcctacc tgatatcgcc tccttggaag aggttcccaa gatcttcgag    36360

ggtctgggca gcgacgagac tcgggccgcg aacgctctgc aaggagaagg aggaggagag    36420

catgagcacc acagcgccct ggtcgagttg gaaggcgaca acgcgcggct ggcggtgctc    36480

aaacgcacgg tcgagctgac ccatttcgcc tacccggctc tgaacctgcc cccgaaagtc    36540

atgagcgcgg tcatggacca ggtgctcatc aagcgcgcgt cgcccatctc cgaggacgag    36600

ggcatgcaag actccgagga gggcaagccc gtggtcagcg acgagcagct ggcccggtgg    36660

ctgggtccta atgctacccc tcaaagtttg gaagagcggc gcaagctcat gatggccgtg    36720

gtcctggtga ccgtggagct ggagtgcctg cgccgcttct tcgccgacgc ggagaccctg    36780

cgcaaggtcg aggagaacct gcactacctc ttcaggcacg ggttcgtgcg ccaggcctgc    36840

aagatctcca acgtggagct gaccaacctg gtctcctaca tgggcatctt gcacgagaac    36900

cgcctggggc agaacgtgct gcacaccacc ctgcgcgggg aggcccgccg cgactacatc    36960

cgcgactgcg tctacctcta cctctgccac acctggcaga cgggcatggg cgtgtggcag    37020

cagtgtctgg aggagcagaa cctgaaagag ctctgcaagc tcctgcaaaa gaacctcaag    37080

ggtctgtgga ccgggttcga cgagcggacc accgcctcgg acctggccga cctcatcttc    37140

cccgagcgcc tcaggctgac gctgcgcaac ggcctgcccg actttatgag ccaaagcatg    37200

ttgcaaaact ttcgctcttt catcctcgaa cgctccggaa tcctgcccgc cacctgctcc    37260

gcgctgccct cggacttcgt gccgctgacc ttccgcgagt gccccccgcc gctgtggagc    37320

cactgctacc tgctgcgcct ggccaactac ctggcctacc actcggacgt gatcgaggac    37380

gtcagcggcg agggcctgct cgagtgccac tgccgctgca acctctgcac gccgcaccgc    37440

tccctggcct gcaaccccca gctgctgagc gagacccaga tcatcggcac cttcgagttg    37500

caagggccca gcgagggcga gggagccaag gggggtctga aactcacccc ggggctgtgg    37560

acctcggcct acttgcgcaa gttcgtgccc gaggattacc atcccttcga gatcaggttc    37620

tacgaggacc aatcccagcc gcccaaggcc gagctgtcgg cctgcgtcat cacccagggg    37680

gcgatcctgg cccaattgca agccatccag aaatcccgcc aagaattctt gctgaaaaag    37740

ggccgcgggg tctacctcga cccccagacc ggtgaggagc tcaaccccgg cttcccccag    37800

gatgccccga ggaaacaaga agctgaaagt ggagctgccg cccgtggagg atttggagga    37860

agactgggag aacagcagtc aggcagagga gatggaggaa gactgggaca gcactcaggc    37920

agaggaggac agcctgcaag acagtctgga ggaagacgag gaggaggcag aggaggaggt    37980

ggaagaagca gccgccgcca gaccgtcgtc ctcggcgggg gagaaagcaa gcagcacgga    38040

taccatctcc gctccgggtc ggggtcccgc tcggccccac agtagatggg acgagaccgg    38100

gcgattcccg aaccccacca cccagaccgg taagaaggag cggcagggat acaagtcctg    38160

gcgggggcac aaaaacgcca tcgtctcctg cttgcaggcc tgcgggggca acatctcctt    38220

cacccggcgc tacctgctct tccaccgcgg ggtgaacttc ccccgcaaca tcttgcatta    38280

ctaccgtcac ctccacagcc cctactactt ccaagaagag gcagcagcag cagaaaaaga    38340

ccagaaaacc agctagaaaa tccacagcgg cggcagcggc aggtggactg aggatcgcgg    38400

cgaacgagcc ggcgcagacc cgggagctga ggaaccggat ctttcccacc ctctatgcca    38460

tcttccagca gagtcggggg caggagcagg aactgaaagt caagaaccgt tctctgcgct    38520

cgctcacccg cagttgtctg tatcacaaga gcgaagacca acttcagcgc actctcgagg    38580

acgccgaggc tctcttcaac aagtactgcg cgctcactct taaagagtag cccgcgcccg    38640

cccagtcgca gaaaaaggcg ggaattacgt cacctgtgcc cttcgcccta gccgcctcca    38700

cccagcaccg ccatgagcaa agagattccc acgccttaca tgtggagcta ccagccccag    38760

atgggcctgg ccgccggcgc cgcccaggac tactccaccc gcatgaattg gctcagcgcc    38820

gggcccgcga tgatctcacg ggtgaatgac atccgcgccc accgaaacca gatactccta    38880

gaacagtcag cgctcaccgc cacgccccgc aatcacctca atccgcgtaa ttggcccgcc    38940

gccctggtgt accaggaaat tccccagccc acgaccgtac tacttccgcg agacgcccag    39000

gccgaagtcc agctgactaa ctcaggtgtc cagctggcgg gcggcgccac cctgtgtcgt    39060

caccgccccg ctcagggtat aaagcggctg gtgatccggg gcagaggcac acagctcaac    39120

gacgaggtgg tgagctcttc gctgggtctg cgacctgacg gagtcttcca actcgccgga    39180

tcggggagat cttccttcac gcctcgtcag gcggtcctga ctttggagag ttcgtcctcg    39240

cagccccgct cgggcggcat cggcactctc cagttcgtgg aggagttcac tccctcggtc    39300

tacttcaacc ccttctccgg ctcccccggc cactacccgg acgagttcat cccgaacttt    39360

gacgccatca gcgagtcggt ggacggctac gattgattaa ttaatcaact aaccccttac    39420

ccctttaccc tccagtaaaa ataaagatta aaaatgattg aattgatcaa taaagaatca    39480

cttacttgaa atctgaaacc aggtctctgt ccatgttttc tgtcagcagc acttcactcc    39540

cctcttccca actctggtac tgcaggcccc ggcgggctgc aaacttcctc cacactctga    39600

aggggatgtc aaattcctcc tgtccctcaa tcttcatttt tatcttctat cagatgtcca    39660

aaaagcgcgc gcgggtggat gatggcttcg accccgtgta cccctacgat gcagacaacg    39720

caccgactgt gcccttcatc aaccctccct tcgtctcttc agatggattc caagaaaagc    39780

ccctgggggt gttgtccctg cgactggccg accccgtcac caccaagaat ggggctgtca    39840

ccctcaagct gggggagggg gtggacctcg acgactcggg aaaactcatc tccaaaaatg    39900

ccaccaaggc cactgcccct ctcagtattt ccaacggcac catttccctt aacatggctg    39960

ccccttttta caacaacaat ggaacgttaa gtctcaatgt ttctacacca ttagcagtat    40020

ttcccacttt taacacttta ggtatcagtc ttggaaacgg tcttcaaact tctaataagt    40080

tgctgactgt acagttaact catcctctta cattcagctc aaatagcatc acagtaaaaa    40140

cagacaaagg actctatatt aattctagtg gaaacagagg gcttgaggct aacataagcc    40200

taaaaagagg actgattttt gatggtaatg ctattgcaac ataccttgga agtggtttag    40260

actatggatc ctatgatagc gatgggaaaa caagacccat catcaccaaa attggagcag    40320

gtttgaattt tgatgctaat aatgccatgg ctgtgaagct aggcacaggt ttaagttttg    40380

actctgccgg tgccttaaca gctggaaaca aagaggatga caagctaaca ctttggacta    40440

cacctgaccc aagccctaat tgtcaattac tttcagacag agatgccaaa tttaccctat    40500

gtcttacaaa atgcggtagt caaatactag gcactgttgc agtagctgct gttactgtag    40560

gttcagcact aaatccaatt aatgacacag taaaaagcgc catagtattc cttagatttg    40620

actctgacgg tgtgctcatg tcaaactcat caatggtagg tgattactgg aactttaggg    40680

aaggacagac cacccaaagt gtggcctata caaatgctgt gggattcatg cccaatctag    40740

gtgcatatcc taaaacccaa agcaaaacac caaaaaatag tatagtaagt caggtatatt    40800

taaatggaga aactactatg ccaatgacac tgacaataac tttcaatggc actgatgaaa    40860

aagacacaac acctgtgagc acttactcca tgacttttac atggcagtgg actggagact    40920

ataaggacaa gaatattacc tttgctacca actcctttac tttctcctac atggcccaag    40980

aataaaccct gcatgccaac cccattgttc ccaccactat ggaaaactct gaagcagaaa    41040

aaaataaagt tcaagtgttt tattgattca acagttttct cacagaaccc tagtattcaa    41100

cctgccacct ccctcccaac acacagagta cacagtcctt tctccccggc tggccttaaa    41160

aagcatcata tcatgggtaa cagacatatt cttaggtgtt atattccaca cggtttcctg    41220

tcgagccaaa cgctcatcag tgatattaat aaactccccg ggcagctcac ttaagttcat    41280

gtcgctgtcc agctgctgag ccacaggctg ctgtccaact tgcggttgct taacgggcgg    41340

cgaaggagaa gtccacgcct acatgggggt agagtcataa tcgtgcatca ggatagggcg    41400

gtggtgctgc agcagcgcgc gaataaactg ctgccgccgc cgctccgtcc tgcaggaata    41460

caacatggca gtggtctcct cagcgatgat tcgcaccgcc cgcagcataa ggcgccttgt    41520

cctccgggca cagcagcgca ccctgatctc acttaaatca gcacagtaac tgcagcacag    41580

caccacaata ttgttcaaaa tcccacagtg caaggcgctg tatccaaagc tcatggcggg    41640

gaccacagaa cccacgtggc catcatacca caagcgcagg tagattaagt ggcgacccct    41700

cataaacacg ctggacataa acattacctc ttttggcatg ttgtaattca ccacctcccg    41760

gtaccatata aacctctgat taaacatggc gccatccacc accatcctaa accagctggc    41820

caaaacctgc ccgccggcta tacactgcag ggaaccggga ctggaacaat gacagtggag    41880

agcccaggac tcgtaaccat ggatcatcat gctcgtcatg atatcaatgt tggcacaaca    41940

caggcacacg tgcatacact tcctcaggat tacaagctcc tcccgcgtta gaaccatatc    42000

ccagggaaca acccattcct gaatcagcgt aaatcccaca ctgcagggaa gacctcgcac    42060

gtaactcacg ttgtgcattg tcaaagtgtt acattcgggc agcagcggat gatcctccag    42120

tatggtagcg cgggtttctg tctcaaaagg aggtagacga tccctactgt acggagtgcg    42180

ccgagacaac cgagatcgtg ttggtcgtag tgtcatgcca aatggaacgc cggacgtagt    42240

catatttcct gaagcaaaac caggtgcggg cgtgacaaac agatctgcgt ctccggtctc    42300

gccgcttaga tcgctctgtg tagtagttgt agtatatcca ctctctcaaa gcatccaggc    42360

gccccctggc ttcgggttct atgtaaactc cttcatgcgc cgctgccctg ataacatcca    42420

ccaccgcaga ataagccaca cccagccaac ctacacattc gttctgcgag tcacacacgg    42480

gaggagcggg aagagctgga agaaccatga ttaactttat tccaaacggt ctcggagcac    42540

ttcaaaatgc aggtcccgga ggtggcacct ctcgccccca ctgtgttggt ggaaaataac    42600

agccaggtca aaggtgacac ggttctcgag atgttccacg gtggcttcca gcaaagcctc    42660

cacgcgcaca tccagaaaca agaggacagc gaaagcggga gcgttttcta attcctcaat    42720

catcatatta cactcctgca ccatccccag ataattttca tttttccagc cttgaatgat    42780

tcgtattagt tcctgaggta aatccaagcc agccatgata aaaagctcgc gcagagcgcc    42840

ctccaccggc attcttaagc acaccctcat aattccaaga gattctgctc ctggttcacc    42900

tgcagcagat taacaatggg aatatcaaaa tctctgccgc gatccctaag ctcctccctc    42960

aacaataact gtatgtaatc tttcatatca tctccgaaat ttttagccat agggccgcca    43020

ggaataagag cagggcaagc cacattacag ataaagcgaa gtcctcccca gtgagcattg    43080

ccaaatgtaa gattgaaata agcatgctgg ctagaccctg tgatatcttc cagataactg    43140

gacagaaaat caggcaagca atttttaaga aaatcaacaa aagaaaagtc gtccaggtgc    43200

aggtttagag cctcaggaac aacgatggaa taagtgcaag gagtgcgttc cagcatggtt    43260

agtgtttttt tggtgatctg tagaacaaaa aataaacatg caatattaaa ccatgctagc    43320

ctggcgaaca ggtgggtaaa tcactctttc cagcaccagg caggctacgg ggtctccggc    43380

gcgaccctcg tagaagctgt cgccatgatt gaaaagcatc accgagagac cttcccggtg    43440

gccggcatgg atgattcgag aagaagcata cactccggga acattggcat ccgtgagtga    43500

aaaaaagcga cctataaagc ctcggggcac tacaatgctc aatctcaatt ccagcaaagc    43560

caccccatgc ggatggagca caaaattggc aggtgcgtaa aaaatgtaat tactcccctc    43620

ctgcacaggc agcaaagccc ccgctccctc cagaaacaca tacaaagcct cagcgtccat    43680

agcttaccga gcacggcagg cgcaagagtc agagaaaagg ctgagctcta acctgactgc    43740

ccgctcctgt gctcaatata tagccctaac ctacactgac gtaaaggcca aagtctaaaa    43800

atacccgcca aaatgacaca cacgcccagc acacgcccag aaaccggtga cacactcaaa    43860

aaaatacgtg cgcttcctca aacgcccaaa ccggcgtcat ttccgggttc ccacgctacg    43920

tcaccgctca gcgactttca aattccgtcg accgttaaaa acgtcactcg ccccgcccct    43980

aacggtcgcc cttctctcgg ccaatcacct tcctcccttc ccaaattcaa acgcctcatt    44040

tgcatattaa cgcgcacaaa aagtttgagg tatatatttg aatgatggtt taaac         44095


<210>  14
<211>  30960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ChAdOx1: Viral vector based on Chimpanzee adenovirus C68

<400>  14
ccatcatcaa taatatacct caaacttttt gtgcgcgtta atatgcaaat gaggcgtttg       60

aatttgggaa gggaggaagg tgattggccg agagaagggc gaccgttagg ggcggggcga      120

gtgacgtttt gatgacgtga ccgcgaggag gagccagttt gcaagttctc gtgggaaaag      180

tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca attttcccgc gctctctgac      240

aggaaatgag gtgtttctag gcggatgcaa gtgaaaacgg gccattttcg cgcgaaaact      300

gaatgaggaa gtgaaaatct gagtaatttc gcgtttatga cagggaggag tatttgccga      360

gggccgagta gactttgacc gattacgtgg gggtttcgat taccgtgttt ttcacctaaa      420

tttccgcgta cggtgtcaaa gtccggtgtt tttacgtagg tgtcagctga tcgccagggt      480

atttaaacct gcgctctcca gtcaagaggc cactcttgag tgccagcgag aagagttttc      540

tcctccgcgc gcgagtcaga tctacacttt gaaaggcgat cgctagcgac atcgatcaca      600

agtttgtaca aaaaagctga acgagaaacg taaaatgata taaatatcaa tatattaaat      660

tagattttgc ataaaaaaca gactacataa tactgtaaaa cacaacatat ccagtcacta      720

tggcggccgc cgatttattc aacaaagcca cgttgtgtct caaaatctct gatgttacat      780

tgcacaagat aaaaatatat catcatgaac aataaaactg tctgcttaca taaacagtaa      840

tacaaggggt gttatgagcc atattcaacg ggaaacgtct tgctcgaggc cgcgattaaa      900

ttccaacatg gatgctgatt tatatgggta taaatgggct cgtgataatg tcgggcaatc      960

aggtgcgaca atctatcgat tgtatgggaa gcccgatgcg ccagagttgt ttctgaaaca     1020

tggcaaaggt agcgttgcca atgatgttac agatgagatg gtcagactaa actggctgac     1080

ggaatttatg cctcttccga ccatcaagca ttttatccgt actcctgatg atgcatggtt     1140

actcaccact gcgatccccg ggaaaacagc attccaggta ttagaagaat atcctgattc     1200

aggtgaaaat attgttgatg cgctggcagt gttcctgcgc cggttgcatt cgattcctgt     1260

ttgtaattgt ccttttaaca gcgatcgcgt atttcgtctc gctcaggcgc aatcacgaat     1320

gaataacggt ttggttgatg cgagtgattt tgatgacgag cgtaatggct ggcctgttga     1380

acaagtctgg aaagaaatgc ataagctttt gccattctca ccggattcag tcgtcactca     1440

tggtgatttc tcacttgata accttatttt tgacgagggg aaattaatag gttgtattga     1500

tgttggacga gtcggaatcg cagaccgata ccaggatctt gccatcctat ggaactgcct     1560

cggtgagttt tctccttcat tacagaaacg gctttttcaa aaatatggta ttgataatcc     1620

tgatatgaat aaattgcagt ttcatttgat gctcgatgag tttttctaat cagaattggt     1680

taattggttg taacactggc acgcgtggat ccggcttact aaaagccaga taacagtatg     1740

cgtatttgcg cgctgatttt tgcggtataa gaatatatac tgatatgtat acccgaagta     1800

tgtcaaaaag aggtatgcta tgaagcagcg tattacagtg acagttgaca gcgacagcta     1860

tcagttgctc aaggcatata tgatgtcaat atctccggtc tggtaagcac aaccatgcag     1920

aatgaagccc gtcgtctgcg tgccgaacgc tggaaagcgg aaaatcagga agggatggct     1980

gaggtcgccc ggtttattga aatgaacggc tcttttgctg acgagaacag gggctggtga     2040

aatgcagttt aaggtttaca cctataaaag agagagccgt tatcgtctgt ttgtggatgt     2100

acagagtgat attattgaca cgcccgggcg acggatggtg atccccctgg ccagtgcacg     2160

tctgctgtca gataaagtct cccgtgaact ttacccggtg gtgcatatcg gggatgaaag     2220

ctggcgcatg atgaccaccg atatggccag tgtgccggtc tccgttatcg gggaagaagt     2280

ggctgatctc agccaccgcg aaaatgacat caaaaacgcc attaacctga tgttctgggg     2340

aatataaatg tcaggctccc ttatacacag ccagtctgca ggtcgaccat agtgactgga     2400

tatgttgtgt tttacagtat tatgtagtct gttttttatg caaaatctaa tttaatatat     2460

tgatatttat atcattttac gtttctcgtt cagctttctt gtacaaagtg gtgatcgatt     2520

cgacagatcg cgatcgcagt gagtagtgtt ctggggcggg ggaggacctg catgagggcc     2580

agaatgactg aaatctgtgc ttttctgtgt gttgcagcat catgagcgga agcggctcct     2640

ttgagggagg ggtattcagc ccttatctga cggggcgtct cccctcctgg gcgggagtgc     2700

gtcagaatgt gatgggatcc acggtggacg gccggcccgt gcagcccgcg aactcttcaa     2760

ccctgaccta tgcaaccctg agctcttcgt cggtggacgc agctgccgcc gcagctgctg     2820

catccgccgc cagcgccgtg cgcggaatgg ccatgggcgc cggctactac ggcactctgg     2880

tggccaactc gagttccacc aataatcccg ccagcctgaa cgaggagaag ctgctgctgc     2940

tgatggccca gcttgaggcc ttgacccagc gcctgggcga gctgacccag caggtggctc     3000

agctgcagga gcagacgcgg gccgcggttg ccacggtgaa atccaaataa aaaatgaatc     3060

aataaataaa cggagacggt tgttgatttt aacacagagt ctgaatcttt atttgatttt     3120

tcgcgcgcgg taggccctgg accaccggtc tcgatcattg agcacccggt ggatcttttc     3180

caggacccgg tagaggtggg cttggatgtt gaggtacatg ggcatgagcc cgtcccgggg     3240

gtggaggtag ctccattgca gggcctcgtg ctcgggggtg gtgttgtaaa tcacccagtc     3300

atagcagggg cgcagggcgt ggtgttgcac aatatctttg aggaggagac tgatggccac     3360

gggcagccct ttggtgtagg tgtttacaaa tctgttgagc tgggagggat gcatgcgggg     3420

ggagatgagg tgcatcttgg cctggatctt gagattggcg atgttaccgc ccagatcccg     3480

cctggggttc atgttgtgca ggaccaccag cacggtgtat ccggtgcact tggggaattt     3540

atcatgcaac ttggaaggga aggcgtgaaa gaatttggcg acgcccttgt gtccgcccag     3600

gttttccatg cactcatcca tgatgatggc aatgggcccg tgggcggcgg cctgggcaaa     3660

gacgtttcgg gggtcggaca catcatagtt gtggtcctgg gtgaggtcat cataggccat     3720

tttaatgaat ttggggcgga gggtgccgga ctgggggaca aaggtaccct cgatcccggg     3780

ggcgtagttc ccctcacaga tctgcatctc ccaggctttg agctcagagg gggggatcat     3840

gtccacctgc ggggcgataa agaacacggt ttccggggcg ggggagatga gctgggccga     3900

aagcaagttc cggagcagct gggacttgcc gcagccggtg gggccgtaaa tgaccccgat     3960

gaccggctgc aggtggtagt tgagggagag acagctgccg tcctcccgga ggaggggggc     4020

cacctcgttc atcatctcgc gcacgtgcat gttctcgcgc accagttccg ccaggaggcg     4080

ctctcccccc agagatagga gctcctggag cgaggcgaag tttttcagcg gcttgagtcc     4140

gtcggccatg ggcattttgg agagggtctg ttgcaagagt tccaagcggt cccagagctc     4200

ggtgatgtgc tctacggcat ctcgatccag cagacctcct cgtttcgcgg gttgggacga     4260

ctgcgggagt agggcaccag acgatgggcg tccagcgcag ccagggtccg gtccttccag     4320

ggccgcagcg tccgcgtcag ggtggtctcc gtcacggtga aggggtgcgc gccgggctgg     4380

gcgcttgcga gggtgcgctt caggctcatc cggctggtcg aaaaccgctc ccgatcggcg     4440

ccctgcgcgt cggccaggta gcaattgacc atgagttcgt agttgagcgc ctcggccgcg     4500

tggcctttgg cgcggagctt acctttggaa gtctgcccgc aggcgggaca gaggagggac     4560

ttgagggcgt agagcttggg ggcgaggaag acggaatcgg gggcgtaggc gtccgcgccg     4620

cagtgggcgc agacggtctc gcactccacg agccaggtga ggtcgggctg gtcggggtca     4680

aaaaccagtt tcccgccgtt ctttttgatg cgtttcttac ctttggtctc catgagctcg     4740

tgtccccgct gggtgacaaa gaggctgtcc gtgtccccgt agaccgactt tatgggccgg     4800

tcctcgagcg gtgtgccgcg gtcctcctcg tagaggaacc ccgcccactc cgagacgaaa     4860

gcccgggtcc aggccagcac gaaggaggcc acgtgggacg ggtagcggtc gttgtccacc     4920

agcgggtcca ctttttccag ggtatgcaaa cacatgtccc cctcgtccac atccaggaag     4980

gtgattggct tgtaagtgta ggccacgtga ccgggggtcc cggccggggg ggtataaaag     5040

ggggcgggcc cctgctcgtc ctcactgtct tccggatcgc tgtccaggag cgccagctgt     5100

tggggtaggt attccctctc gaaggcgggc atgacctcgg cactcaggtt gtcagtttct     5160

agaaacgagg aggatttgat attgacggtg ccagcggaga tgcctttcaa gagcccctcg     5220

tccatctggt cagaaaagac gatttttttg ttgtcgagct tggtggcgaa ggagccgtag     5280

agggcgttgg aaaggagctt ggcgatggag cgcatggtct ggtttttttc cttgtcggcg     5340

cgctccttgg ccgcgatgtt gagctgcacg tactcgcgcg ccacgcactt ccattcgggg     5400

aagacggtgg tcatctcgtc gggcacgatt ctgacctgcc aacctcgatt atgcagggtg     5460

atgaggtcca cactggtggc cacctcgccg cgcaggggct cgttggtcca gcagaggcgg     5520

ccgcccttgc gcgagcagaa ggggggcaga gggtccagca tgacctcgtc gggggggtcg     5580

gcatcgatgg tgaagatgcc gggcaggaga tcggggtcga agtagctgat ggaagtggcc     5640

agatcgtcca gggaagcttg ccattcgcgc acggccagcg cgcgctcgta gggactgagg     5700

ggcgtgcccc agggcatggg gtgggtgagc gcggaggcgt acatgccgca gatgtcgtag     5760

acgtagaggg gctcctcgag gatgccgatg taggtggggt agcagcgccc cccgcggatg     5820

ctggcgcgca cgtagtcata cagctcgtgc gagggcgcga ggagccccgg gcccaggttg     5880

gtgcgactgg gcttttcggc gcggtagacg atctggcgaa agatggcatg cgagttggag     5940

gagatggtgg gcctttggaa gatgttgaag tgggcgtggg ggaggccgac cgagtcgcgg     6000

atgaagtggg cgtaggagtc ttgcagtttg gcgacgagct cggcggtgac gaggacgtcc     6060

agagcgcagt agtcgagggt ctcctggatg atgtcatact tgagctggcc cttttgtttc     6120

cacagctcgc ggttgagaag gaactcttcg cggtccttcc agtactcttc gagggggaac     6180

ccgtcctgat ctgcacggta agagcctagc atgtagaact ggttgacggc cttgtaggcg     6240

cagcagccct tctccacggg gagggcgtag gcctgggcgg ccttgcgcag ggaggtgtgc     6300

gtgagggcga aggtgtccct gaccatgacc ttgaggaact ggtgcttgaa atcgatatcg     6360

tcgcagcccc cctgctccca gagctggaag tccgtgcgct tcttgtaggc ggggttgggc     6420

aaagcgaaag taacatcgtt gaaaaggatc ttgcccgcgc ggggcataaa gttgcgagtg     6480

atgcggaaag gctggggcac ctcggcccgg ttgttgatga cctgggcggc gagcacgatc     6540

tcgtcgaaac cgttgatgtt gtggcccacg atgtagagtt ccacgaatcg cgggcggccc     6600

ttgacgtggg gcagcttctt gagctcctcg taggtgagct cgtcggggtc gctgagaccg     6660

tgctgctcga gcgcccagtc ggcgagatgg gggttggcgc ggaggaagga agtccagaga     6720

tccacggcca gggcggtttg cagacggtcc cggtactgac ggaactgctg cccgacggcc     6780

attttttcgg gggtgacgca gtagaaggtg cgggggtccc cgtgccagcg gtcccatttg     6840

agctggaggg cgagatcgag ggcgagctcg acgaggcggt cgtcccctga gagtttcatg     6900

accagcatga aggggacgag ctgcttgccg aaggacccca tccaggtgta ggtttccaca     6960

tcgtaggtga ggaagagcct ttcggtgcga ggatgcgagc cgatggggaa gaactggatc     7020

tcctgccacc aattggagga atggctgttg atgtgatgga agtagaaatg ccgacggcgc     7080

gccgaacact cgtgcttgtg tttatacaag cggccacagt gctcgcaacg ctgcacggga     7140

tgcacgtgct gcacgagctg tacctgagtt cctttgacga ggaatttcag tgggaagtgg     7200

agtcgtggcg cctgcatctc gtgctgtact acgtcgtggt ggtcggcctg gccctcttct     7260

gcctcgatgg tggtcatgct gacgagcccg cgcgggaggc aggtccagac ctcggcgcga     7320

gcgggtcgga gagcgaggac gagggcgcgc aggccggagc tgtccagggt cctgagacgc     7380

tgcggagtca ggtcagtggg cagcggcggc gcgcggttga cttgcaggag tttttccagg     7440

gcgcgcggga ggtccagatg gtacttgatc tccaccgcgc cgttggtggc gacgtcgatg     7500

gcttgcaggg tcccgtgccc ctggggtgtg accaccgtcc cccgtttctt cttgggcggc     7560

tggggcgacg ggggcggtgc ctcttccatg gttagaagcg gcggcgagga cgcgcgccgg     7620

gcggcagagg cggctcgggg cccggaggca ggggcggcag gggcacgtcg gcgccgcgcg     7680

cgggtaggtt ctggtactgc gcccggagaa gactggcgtg agcgacgacg cgacggttga     7740

cgtcctggat ctgacgcctc tgggtgaagg ccacgggacc cgtgagtttg aacctgaaag     7800

agagttcgac agaatcaatc tcggtatcgt tgacggcggc ctgccgcagg atctcttgca     7860

cgtcgcccga gttgtcctgg taggcgatct cggtcatgaa ctgctcgatc tcctcctcct     7920

gaaggtctcc gcgaccggcg cgctccacgg tggccgcgag gtcgttggag atgcggccca     7980

tgagctgcga gaaggcgttc atgcccgcct cgttccagac gcggctgtag accacgacgc     8040

cctcgggatc gcgggcgcgc atgaccacct gggcgaggtt gagctccacg tggcgcgtga     8100

agaccgcgta gttgcagagg cgctggtaga ggtagttgag cgtggtggcg atgtgctcgg     8160

tgacgaagaa atacatgatc cagcggcgga gcggcatctc gctgacgtcg cccagcgcct     8220

ccaagcgttc catggcctcg taaaagtcca cggcgaagtt gaaaaactgg gagttgcgcg     8280

ccgagacggt caactcctcc tccagaagac ggatgagctc ggcgatggtg gcgcgcacct     8340

cgcgctcgaa ggcccccggg agttcctcca cttcctcctc ttcttcctcc tccactaaca     8400

tctcttctac ttcctcctca ggcggtggtg gtggcggggg agggggcctg cgtcgccggc     8460

ggcgcacggg cagacggtcg atgaagcgct cgatggtctc gccgcgccgg cgtcgcatgg     8520

tctcggtgac ggcgcgcccg tcctcgcggg gccgcagcgt gaagacgccg ccgcgcatct     8580

ccaggtggcc gggggggtcc ccgttgggca gggagagggc gctgacgatg catcttatca     8640

attgccccgt agggactccg cgcaaggacc tgagcgtctc gagatccacg ggatctgaaa     8700

accgttgaac gaaggcttcg agccagtcgc agtcgcaagg taggctgagc acggtttctt     8760

ctgccgggtc atgttgggga gcggggcggg cgatgctgct ggtgatgaag ttgaaatagg     8820

cggttctgag acggcggatg gtggcgagga gcaccaggtc tttgggcccg gcttgctgga     8880

tgcgcagacg gtcggccatg ccccaggcgt ggtcctgaca cctggccagg tccttgtagt     8940

agtcctgcat gagccgctcc acgggcacct cctcctcgcc cgcgcggccg tgcatgcgcg     9000

tgagcccgaa gccgcgctgg ggctggacga gcgccaggtc ggcgacgacg cgctcggcga     9060

ggatggcctg ctggatctgg gtgagggtgg tctggaagtc gtcaaagtcg acgaagcggt     9120

ggtaggctcc ggtgttgatg gtgtaggagc agttggccat gacggaccag ttgacggtct     9180

ggtggcccgg acgcacgagc tcgtggtact tgaggcgcga gtaggcgcgc gtgtcgaaga     9240

tgtagtcgtt gcaggtgcgc accaggtact ggtagccgat gaggaagtgc ggcggcggct     9300

ggcggtagag cggccatcgc tcggtggcgg gggcgccggg cgcgaggtcc tcgagcatgg     9360

tgcggtggta gccgtagatg tacctggaca tccaggtgat gccggcggcg gtggtggagg     9420

cgcgcgggaa ctcgcggacg cggttccaga tgttgcgcag cggcaggaag tagttcatgg     9480

tgggcacggt ctggcccgtg aggcgcgcgc agtcgtggat gctctatacg ggcaaaaacg     9540

aaagcggtca gcggctcgac tccgtggcct ggaggctaag cgaacgggtt gggctgcgcg     9600

tgtaccccgg ttcgaatctc gaatcaggct ggagccgcag ctaacgtggt actggcactc     9660

ccgtctcgac ccaagcctgc accaaccctc caggatacgg aggcgggtcg ttttgcaact     9720

ttttttggag gccggaaatg aaactagtaa gcgcggaaag cggccgaccg cgatggctcg     9780

ctgccgtagt ctggagaaga atcgccaggg ttgcgttgcg gtgtgccccg gttcgaggcc     9840

ggccggattc cgcggctaac gagggcgtgg ctgccccgtc gtttccaaga ccccatagcc     9900

agccgacttc tccagttacg gagcgagccc ctcttttgtt ttgtttgttt ttgccagatg     9960

catcccgtac tgcggcagat gcgcccccac caccctccac cgcaacaaca gccccctcct    10020

ccacagccgg cgcttctgcc cccgccccag cagcagcagc aacttccagc cacgaccgcc    10080

gcggccgccg tgagcggggc tggacagact tctcagtatg atcacctggc cttggaagag    10140

ggcgaggggc tggcgcgcct gggggcgtcg tcgccggagc ggcacccgcg cgtgcagatg    10200

aaaagggacg ctcgcgaggc ctacgtgccc aagcagaacc tgttcagaga caggagcggc    10260

gaggagcccg aggagatgcg cgcggcccgg ttccacgcgg ggcgggagct gcggcgcggc    10320

ctggaccgaa agagggtgct gagggacgag gatttcgagg cggacgagct gacggggatc    10380

agccccgcgc gcgcgcacgt ggccgcggcc aacctggtca cggcgtacga gcagaccgtg    10440

aaggaggaga gcaacttcca aaaatccttc aacaaccacg tgcgcaccct gatcgcgcgc    10500

gaggaggtga ccctgggcct gatgcacctg tgggacctgc tggaggccat cgtgcagaac    10560

cccaccagca agccgctgac ggcgcagctg ttcctggtgg tgcagcatag tcgggacaac    10620

gaggcgttca gggaggcgct gctgaatatc accgagcccg agggccgctg gctcctggac    10680

ctggtgaaca ttctgcagag catcgtggtg caggagcgcg ggctgccgct gtccgagaag    10740

ctggcggcca tcaacttctc ggtgctgagt ctgggcaagt actacgctag gaagatctac    10800

aagaccccgt acgtgcccat agacaaggag gtgaagatcg acgggtttta catgcgcatg    10860

accctgaaag tgctgaccct gagcgacgat ctgggggtgt accgcaacga caggatgcac    10920

cgcgcggtga gcgccagcag gcggcgcgag ctgagcgacc aggagctgat gcacagcctg    10980

cagcgggccc tgaccggggc cgggaccgag ggggagagct actttgacat gggcgcggac    11040

ctgcactggc agcccagccg ccgggccttg gaggcggcag gcggtccccc ctacatagaa    11100

gaggtggacg atgaggtgga cgaggagggc gagtacctgg aagactgatg gcgcgaccgt    11160

atttttgcta gatgcaacaa cagccacctc ctgatcccgc gatgcgggcg gcgctgcaga    11220

gccagccgtc cggcattaac tcctcggacg attggaccca ggccatgcaa cgcatcatgg    11280

cgctgacgac ccgcaacccc gaagccttta gacagcagcc ccaggccaac cggctctcgg    11340

ccatcctgga ggccgtggtg ccctcgcgct ccaaccccac gcacgagaag gtcctggcca    11400

tcgtgaacgc gctggtggag aacaaggcca tccgcggcga cgaggccggc ctggtgtaca    11460

acgcgctgct ggagcgcgtg gcccgctaca acagcaccaa cgtgcagacc aacctggacc    11520

gcatggtgac cgacgtgcgc gaggccgtgg cccagcgcga gcggttccac cgcgagtcca    11580

acctgggatc catggtggcg ctgaacgcct tcctcagcac ccagcccgcc aacgtgcccc    11640

ggggccagga ggactacacc aacttcatca gcgccctgcg cctgatggtg accgaggtgc    11700

cccagagcga ggtgtaccag tccgggccgg actacttctt ccagaccagt cgccagggct    11760

tgcagaccgt gaacctgagc caggcgttca agaacttgca gggcctgtgg ggcgtgcagg    11820

ccccggtcgg ggaccgcgcg acggtgtcga gcctgctgac gccgaactcg cgcctgctgc    11880

tgctgctggt ggcccccttc acggacagcg gcagcatcaa ccgcaactcg tacctgggct    11940

acctgattaa cctgtaccgc gaggccatcg gccaggcgca cgtggacgag cagacctacc    12000

aggagatcac ccacgtgagc cgcgccctgg gccaggacga cccgggcaat ctggaagcca    12060

ccctgaactt tttgctgacc aaccggtcgc agaagatccc gccccagtac acgctcagcg    12120

ccgaggagga gcgcatcctg cgatacgtgc agcagagcgt gggcctgttc ctgatgcagg    12180

agggggccac ccccagcgcc gcgctcgaca tgaccgcgcg caacatggag cccagcatgt    12240

acgccagcaa ccgcccgttc atcaataaac tgatggacta cttgcatcgg gcggccgcca    12300

tgaactctga ctatttcacc aacgccatcc tgaatcccca ctggctcccg ccgccggggt    12360

tctacacggg cgagtacgac atgcccgacc ccaatgacgg gttcctgtgg gacgatgtgg    12420

acagcagcgt gttctccccc cgaccgggtg ctaacgagcg ccccttgtgg aagaaggaag    12480

gcagcgaccg acgcccgtcc tcggcgctgt ccggccgcga gggtgctgcc gcggcggtgc    12540

ccgaggccgc cagtcctttc ccgagcttgc ccttctcgct gaacagtatt cgcagcagcg    12600

agctgggcag gatcacgcgc ccgcgcttgc tgggcgagga ggagtacttg aatgactcgc    12660

tgttgagacc cgagcgggag aagaacttcc ccaataacgg gatagagagc ctggtggaca    12720

agatgagccg ctggaagacg tatgcgcagg agcacaggga cgatccgtcg cagggggcca    12780

cgagccgggg cagcgccgcc cgtaaacgcc ggtggcacga caggcagcgg ggactgatgt    12840

gggacgatga ggattccgcc gacgacagca gcgtgttgga cttgggtggg agtggtaacc    12900

cgttcgctca cctgcgcccc cgcatcgggc gcatgatgta agagaaaccg aaaataaatg    12960

atactcacca aggccatggc gaccagcgtg cgttcgtttc ttctctgttg ttgtatctag    13020

tatgatgagg cgtgcgtacc cggagggtcc tcctccctcg tacgagagcg tgatgcagca    13080

ggcgatggcg gcggcggcgg cgatgcagcc cccgctggag gctccttacg tgcccccgcg    13140

gtacctggcg cctacggagg ggcggaacag cattcgttac tcggagctgg cacccttgta    13200

cgataccacc cggttgtacc tggtggacaa caagtcggcg gacatcgcct cgctgaacta    13260

ccagaacgac cacagcaact tcctgaccac cgtggtgcag aacaatgact tcacccccac    13320

ggaggccagc acccagacca tcaactttga cgagcgctcg cggtggggcg gtcagctgaa    13380

aaccatcatg cacaccaaca tgcccaacgt gaacgagttc atgtacagca acaagttcaa    13440

ggcgcgggtg atggtctccc gcaagacccc caacggggtg acagtgacag atggtagtca    13500

ggatatcttg gagtatgaat gggtggagtt tgagctgccc gaaggcaact tctcggtgac    13560

catgaccatc gacctgatga acaacgccat catcgacaat tacttggcgg tggggcggca    13620

gaacggggtc ctggagagcg atatcggcgt gaagttcgac actaggaact tcaggctggg    13680

ctgggacccc gtgaccgagc tggtcatgcc cggggtgtac accaacgagg ccttccaccc    13740

cgatattgtc ttgctgcccg gctgcggggt ggacttcacc gagagccgcc tcagcaacct    13800

gctgggcatt cgcaagaggc agcccttcca ggagggcttc cagatcatgt acgaggatct    13860

ggaggggggc aacatccccg cgctcctgga tgtcgacgcc tatgagaaaa gcaaggagga    13920

gagcgccgcc gcggcgactg cagctgtagc caccgcctct accgaggtca ggggcgataa    13980

ttttgccagc cctgcagcag tggcagcggc cgaggcggct gaaaccgaaa gtaagatagt    14040

cattcagccg gtggagaagg atagcaagga caggagctac aacgtgctgc cggacaagat    14100

aaacaccgcc taccgcagct ggtacctggc ctacaactat ggcgaccccg agaagggcgt    14160

gcgctcctgg acgctgctca ccacctcgga cgtcacctgc ggcgtggagc aagtctactg    14220

gtcgctgccc gacatgatgc aagacccggt caccttccgc tccacgcgtc aagttagcaa    14280

ctacccggtg gtgggcgccg agctcctgcc cgtctactcc aagagcttct tcaacgagca    14340

ggccgtctac tcgcagcagc tgcgcgcctt cacctcgctc acgcacgtct tcaaccgctt    14400

ccccgagaac cagatcctcg tccgcccgcc cgcgcccacc attaccaccg tcagtgaaaa    14460

cgttcctgct ctcacagatc acgggaccct gccgctgcgc agcagtatcc ggggagtcca    14520

gcgcgtgacc gttactgacg ccagacgccg cacctgcccc tacgtctaca aggccctggg    14580

catagtcgcg ccgcgcgtcc tctcgagccg caccttctaa aaaatgtcca ttctcatctc    14640

gcccagtaat aacaccggtt ggggcctgcg cgcgcccagc aagatgtacg gaggcgctcg    14700

ccaacgctcc acgcaacacc ccgtgcgcgt gcgcgggcac ttccgcgctc cctggggcgc    14760

cctcaagggc cgcgtgcggt cgcgcaccac cgtcgacgac gtgatcgacc aggtggtggc    14820

cgacgcgcgc aactacaccc ccgccgccgc gcccgtctcc accgtggacg ccgtcatcga    14880

cagcgtggtg gccgacgcgc gccggtacgc ccgcgccaag agccggcggc ggcgcatcgc    14940

ccggcggcac cggagcaccc ccgccatgcg cgcggcgcga gccttgctgc gcagggccag    15000

gcgcacggga cgcagggcca tgctcagggc ggccagacgc gcggcttcag gcgccagcgc    15060

cggcaggacc cggagacgcg cggccacggc ggcggcagcg gccatcgcca gcatgtcccg    15120

cccgcggcga gggaacgtgt actgggtgcg cgacgccgcc accggtgtgc gcgtgcccgt    15180

gcgcacccgc ccccctcgca cttgaagatg ttcacttcgc gatgttgatg tgtcccagcg    15240

gcgaggagga tgtccaagcg caaattcaag gaagagatgc tccaggtcat cgcgcctgag    15300

atctacggcc ccgcggtggt gaaggaggaa agaaagcccc gcaaaatcaa gcgggtcaaa    15360

aaggacaaaa aggaagaaga tgacgatctg gtggagtttg tgcgcgagtt cgccccccgg    15420

cggcgcgtgc agtggcgcgg gcggaaagtg cacccggtgc tgagacccgg caccaccgtg    15480

gtcttcacgc ccggcgagcg ctccggcagc gcttccaagc gctcctacga cgaggtgtac    15540

ggggacgagg acatcctcga gcaggcggcc gagcgcctgg gcgagtttgc ttacggcaag    15600

cgcagccgcc ccgccctgaa ggaagaggcg gtgtccatcc cgctggacca cggcaacccc    15660

acgccgagcc tcaagcccgt gaccctgcag caggtgctgc cgagcgcagc gccgcgccgg    15720

gggttcaagc gcgagggcga ggatctgtac cccaccatgc agctgatggt gcccaagcgc    15780

cagaagctgg aagacgtgct ggagaccatg aaggtggacc cggacgtgca gcccgaggtc    15840

aaggtgcggc ccatcaagca ggtggccccg ggcctgggcg tgcagaccgt ggacatcaag    15900

atccccacgg agcccatgga aacgcagacc gagcccatga tcaagcccag caccagcacc    15960

atggaggtgc agacggatcc ctggatgcca tcggctccta gccgaagacc ccggcgcaag    16020

tacggcgcgg ccagcctgct gatgcccaac tacgcgctgc atccttccat catccccacg    16080

ccgggctacc gcggcacgcg cttctaccgc ggtcatacaa ccagccgccg ccgcaagacc    16140

accacccgcc gccgccgtcg ccgcacagcc gctgcatcta cccctgccgc cctggtgcgg    16200

agagtgtacc gccgcggccg cgcgcctctg accctaccgc gcgcgcgcta ccacccgagc    16260

atcgccattt aaactttcgc ctgctttgca gatggccctc acatgccgcc tccgcgttcc    16320

cattacgggc taccgaggaa gaaaaccgcg ccgtagaagg ctggcgggga acgggatgcg    16380

tcgccaccac catcggcggc ggcgcgccat cagcaagcgg ttggggggag gcttcctgcc    16440

cgcgctgatc cccatcatcg ccgcggcgat cggggcgatc cccggcattg cttccgtggc    16500

ggtgcaggcc tctcagcgcc actgagacac ttggaaaaca tcttgtaata aaccaatgga    16560

ctctgacgct cctggtcctg tgatgtgttt tcgtagacag atggaagaca tcaatttttc    16620

gtccctggct ccgcgacacg gcacgcggcc gttcatgggc acctggagcg acatcggcac    16680

cagccaactg aacgggggcg ccttcaattg gagcagtctc tggagcgggc ttaagaattt    16740

cgggtccacg cttaaaacct atggcagcaa ggcgtggaac agcaccacag ggcaggcgct    16800

gagggataag ctgaaagagc agaacttcca gcagaaggtg gtcgatgggc tcgcctcggg    16860

catcaacggg gtggtggacc tggccaacca ggccgtgcag cggcagatca acagccgcct    16920

ggacccggtg ccgcccgccg gctccgtgga gatgccgcag gtggaggagg agctgcctcc    16980

cctggacaag cggggcgaga agcgaccccg ccccgacgcg gaggagacgc tgctgacgca    17040

cacggacgag ccgcccccgt acgaggaggc ggtgaaactg ggtctgccca ccacgcggcc    17100

catcgcgccc ctggccaccg gggtgctgaa acccgaaagt aataagcccg cgaccctgga    17160

cttgcctcct cccgcttccc gcccctctac agtggctaag cccctgccgc cggtggccgt    17220

ggcccgcgcg cgacccgggg gctccgcccg ccctcatgcg aactggcaga gcactctgaa    17280

cagcatcgtg ggtctgggag tgcagagtgt gaagcgccgc cgctgctatt aaacctaccg    17340

tagcgcttaa cttgcttgtc tgtgtgtgta tgtattatgt cgccgctgtc cgccagaagg    17400

aggagtgaag aggcgcgtcg ccgagttgca agatggccac cccatcgatg ctgccccagt    17460

gggcgtacat gcacatcgcc ggacaggacg cttcggagta cctgagtccg ggtctggtgc    17520

agttcgcccg cgccacagac acctacttca gtctggggaa caagtttagg aaccccacgg    17580

tggcgcccac gcacgatgtg accaccgacc gcagccagcg gctgacgctg cgcttcgtgc    17640

ccgtggaccg cgaggacaac acctactcgt acaaagtgcg ctacacgctg gccgtgggcg    17700

acaaccgcgt gctggacatg gccagcacct actttgacat ccgcggcgtg ctggatcggg    17760

gccctagctt caaaccctac tccggcaccg cctacaacag cctggctccc aagggagcgc    17820

ccaattccag ccagtgggag caaaaaaagg caggcaatgg tgacactatg gaaacacaca    17880

catttggtgt ggccccaatg ggcggtgaga atattacaat cgacggatta caaattggaa    17940

ctgacgctac agctgatcag gataaaccaa tttatgctga caaaacattc cagcctgaac    18000

ctcaagtagg agaagaaaat tggcaagaaa ctgaaagctt ttatggcggt agggctctta    18060

aaaaagacac aagcatgaaa ccttgctatg gctcctatgc tagacccacc aatgtaaagg    18120

gaggtcaagc taaacttaaa gttggagctg atggagttcc taccaaagaa tttgacatag    18180

acctggcttt ctttgatact cccggtggca cagtgaatgg acaagatgag tataaagcag    18240

acattgtcat gtataccgaa aacacgtatc tggaaactcc agacacgcat gtggtataca    18300

aaccaggcaa ggatgatgca agttctgaaa ttaacctggt tcagcagtcc atgcccaata    18360

gacccaacta tattgggttc agagacaact ttattgggct catgtattac aacagtactg    18420

gcaatatggg ggtgctggct ggtcaggcct cacagctgaa tgctgtggtc gacttgcaag    18480

acagaaacac cgagctgtca taccagctct tgcttgactc tttgggtgac agaacccggt    18540

atttcagtat gtggaatcag gcggtggaca gttatgatcc tgatgtgcgc attattgaaa    18600

accatggtgt ggaagacgaa cttcccaact attgcttccc cctggatggg tctggcacta    18660

atgccgctta ccaaggtgtg aaagtaaaaa atggtaacga tggtgatgtt gagagcgaat    18720

gggaaaatga tgatactgtc gcagctcgaa atcaattatg caagggcaac atttttgcca    18780

tggaaattaa cctccaagcc aacctgtgga gaagtttcct ctactcgaac gtggccctgt    18840

acctgcccga ctcttacaag tacacgccag ccaacatcac cctgcccacc aacaccaaca    18900

cttatgatta catgaacggg agagtggtgc ctccctcgct ggtggacgcc tacatcaaca    18960

tcggggcgcg ctggtcgctg gaccccatgg acaacgtcaa tcccttcaac caccaccgca    19020

acgcgggcct gcgctaccgc tccatgctcc tgggcaacgg gcgctacgtg cccttccaca    19080

tccaggtgcc ccagaaattt ttcgccatca agagcctcct gctcctgccc gggtcctaca    19140

cctacgagtg gaacttccgc aaggacgtca acatgatcct gcagagctcc ctcggcaacg    19200

acctgcgcac ggacggggcc tccatctcct tcaccagcat caacctctac gccaccttct    19260

tccccatggc gcacaacacg gcctccacgc tcgaggccat gctgcgcaac gacaccaacg    19320

accagtcctt caacgactac ctctcggcgg ccaacatgct ctaccccatc ccggccaacg    19380

ccaccaacgt gcccatctcc atcccctcgc gcaactgggc cgccttccgc ggctggtcct    19440

tcacgcgcct caagaccaag gagacgccct cgctgggctc cgggttcgac ccctacttcg    19500

tctactcggg ctccatcccc tacctcgacg gcaccttcta cctcaaccac accttcaaga    19560

aggtctccat caccttcgac tcctccgtca gctggcccgg caacgaccgg ctcctgacgc    19620

ccaacgagtt cgaaatcaag cgcaccgtcg acggcgaggg atacaacgtg gcccagtgca    19680

acatgaccaa ggactggttc ctggtccaga tgctggccca ctacaacatc ggctaccagg    19740

gcttctacgt gcccgagggc tacaaggacc gcatgtactc cttcttccgc aacttccagc    19800

ccatgagccg ccaggtggtg gacgaggtca actacaagga ctaccaggcc gtcaccctgg    19860

cctaccagca caacaactcg ggcttcgtcg gctacctcgc gcccaccatg cgccagggcc    19920

agccctaccc cgccaactac ccgtacccgc tcatcggcaa gagcgccgtc accagcgtca    19980

cccagaaaaa gttcctctgc gacagggtca tgtggcgcat ccccttctcc agcaacttca    20040

tgtccatggg cgcgctcacc gacctcggcc agaacatgct ctatgccaac tccgcccacg    20100

cgctagacat gaatttcgaa gtcgacccca tggatgagtc cacccttctc tatgttgtct    20160

tcgaagtctt cgacgtcgtc cgagtgcacc agccccaccg cggcgtcatc gaggccgtct    20220

acctgcgcac ccccttctcg gccggtaacg ccaccaccta aattgctact tgcatgatgg    20280

ctgagcccac aggctccggc gagcaggagc tcagggccat catccgcgac ctgggctgcg    20340

ggccctactt cctgggcacc ttcgataagc gcttcccggg attcatggcc ccgcacaagc    20400

tggcctgcgc catcgtcaac acggccggcc gcgagaccgg gggcgagcac tggctggcct    20460

tcgcctggaa cccgcgctcg aacacctgct acctcttcga ccccttcggg ttctcggacg    20520

agcgcctcaa gcagatctac cagttcgagt acgagggcct gctgcgccgt agcgccctgg    20580

ccaccgagga ccgctgcgtc accctggaaa agtccaccca gaccgtgcag ggtccgcgct    20640

cggccgcctg cgggctcttc tgctgcatgt tcctgcacgc cttcgtgcac tggcccgacc    20700

gccccatgga caagaacccc accatgaact tgctgacggg ggtgcccaac ggcatgctcc    20760

agtcgcccca ggtggaaccc accctgcgcc gcaaccagga ggcgctctac cgcttcctca    20820

actcccactc cgcctacttt cgctcccacc gcgcgcgcat cgagaaggcc accgccttcg    20880

accgcatgaa caatcaagac atgtaaaccg tgtgtgtatg tttaaaatat cttttaataa    20940

acagcacttt aatgttacac atgcatctga gatgatttta ttttagaaat cgaaagggtt    21000

ctgccgggtc tcggcatggc ccgcgggcag ggacacgttg cggaactggt acttggccag    21060

ccacttgaac tcggggatca gcagtttggg cagcggggtg tcggggaagg agtcggtcca    21120

cagcttccgc gtcagctgca gggcgcccag caggtcgggc gcggagatct tgaaatcgca    21180

gttgggaccc gcgttctgcg cgcgagagtt gcggtacacg gggttgcagc actggaacac    21240

catcagggcc gggtgcttca cgctcgccag caccgccgcg tcggtgatgc tctccacgtc    21300

gaggtcctcg gcgttggcca tcccgaaggg ggtcatcttg caggtctgcc ttcccatggt    21360

gggcacgcac ccgggcttgt ggttgcaatc gcagtgcagg gggatcagca tcatctgggc    21420

ctggtcggcg ttcatccccg ggtacatggc cttcatgaaa gcctccaatt gcctgaacgc    21480

ctgctgggcc ttggctccct cggtgaagaa gaccccgcag gacttgctag agaactggtt    21540

ggtggcacag ccggcatcgt gcacgcagca gcgcgcgtcg ttgttggcca gctgcaccac    21600

gctgcgcccc cagcggttct gggtgatctt ggcccggtcg gggttctcct tcagcgcgcg    21660

ctgcccgttc tcgctcgcca catccatctc gatcatgtgc tccttctgga tcatggtggt    21720

cccgtgcagg caccgcagtt tgccctcggc ctcggtgcac ccgtgcagcc acagcgcgca    21780

cccggtgcac tcccagttct tgtgggcgat ctgggaatgc gcgtgcacga acccttgcag    21840

gaagcggccc atcatggtcg tcagggtctt gttgctagtg aaggtcaacg ggatgccgcg    21900

gtgctcctcg ttgatgtaca ggtggcagat gcggcggtac acctcgccct gctcgggcat    21960

cagttggaag ttggctttca ggtcggtctc cacgcggtag cggtccatca gcatagtcat    22020

gatttccatg cccttctccc aggccgagac gatgggcagg ctcatagggt tcttcaccat    22080

catcttagca ctagcagccg cggccagggg gtcgctctca tccagggtct caaagctccg    22140

cttgccgtcc ttctcggtga tccgcaccgg ggggtagctg aagcccacgg ccgccagctc    22200

ctcctcggcc tgtctttcgt cctcgctgtc ctggctgacg tcctgcatga ccacatgctt    22260

ggtcttgcgg ggtttcttct tgggcggcag tggcggcgga gatgcttgtg gcgaggggga    22320

gcgcgagttc tcgctcacca ctactatctc ttcctcttct tggtccgagg ccacgcggcg    22380

gtaggtatgt ctcttcgggg gcagaggcgg aggcgacggg ctctcgccgc cgcgacttgg    22440

cggatggctg gcagagcccc ttccgcgttc gggggtgcgc tcccggcggc gctctgactg    22500

acttcctccg cggccggcca ttgtgttctc ctagggagga acaacaagca tggagactca    22560

gccatcgcca acctcgccat ctgcccccac cgccggcgac gagaagcagc agcagcagaa    22620

tgaaagctta accgccccgc cgcccagccc cgcctccgac gcagccgcgg tcccagacat    22680

gcaagagatg gaggaatcca tcgagattga cctgggctat gtgacgcccg cggagcatga    22740

ggaggagctg gcagtgcgct ttcaatcgtc aagccaggaa gataaagaac agccagagca    22800

ggaagcagag aacgagcaga gtcaggctgg gctcgagcat ggcgactacc tccacctgag    22860

cggggaggag gacgcgctca tcaagcatct ggcccggcag gccaccatcg tcaaggacgc    22920

gctgctcgac cgcaccgagg tgcccctcag cgtggaggag ctcagccgcg cctacgagct    22980

caacctcttc tcgccgcgcg tgccccccaa gcgccagccc aacggcacct gcgagcccaa    23040

cccccgcctc aacttctacc cggtcttcgc ggtgcccgag gccctggcca cctaccacat    23100

ctttttcaag aaccaaaaga tccccgtctc ctgccgcgcc aaccgcaccc gcgccgacgc    23160

cctcttcaac ctgggtcccg gcgcccgcct acctgatatc gcctccttgg aagaggttcc    23220

caagatcttc gagggtctgg gcagcgacga gactcgggcc gcgaacgctc tgcaaggaga    23280

aggaggagga gagcatgagc accacagcgc cctggtcgag ttggaaggcg acaacgcgcg    23340

gctggcggtg ctcaaacgca cggtcgagct gacccatttc gcctacccgg ctctgaacct    23400

gcccccgaaa gtcatgagcg cggtcatgga ccaggtgctc atcaagcgcg cgtcgcccat    23460

ctccgaggac gagggcatgc aagactccga ggagggcaag cccgtggtca gcgacgagca    23520

gctggcccgg tggctgggtc ctaatgctac ccctcaaagt ttggaagagc ggcgcaagct    23580

catgatggcc gtggtcctgg tgaccgtgga gctggagtgc ctgcgccgct tcttcgccga    23640

cgcggagacc ctgcgcaagg tcgaggagaa cctgcactac ctcttcaggc acgggttcgt    23700

gcgccaggcc tgcaagatct ccaacgtgga gctgaccaac ctggtctcct acatgggcat    23760

cttgcacgag aaccgcctgg ggcagaacgt gctgcacacc accctgcgcg gggaggcccg    23820

ccgcgactac atccgcgact gcgtctacct ctacctctgc cacacctggc agacgggcat    23880

gggcgtgtgg cagcagtgtc tggaggagca gaacctgaaa gagctctgca agctcctgca    23940

aaagaacctc aagggtctgt ggaccgggtt cgacgagcgg accaccgcct cggacctggc    24000

cgacctcatc ttccccgagc gcctcaggct gacgctgcgc aacggcctgc ccgactttat    24060

gagccaaagc atgttgcaaa actttcgctc tttcatcctc gaacgctccg gaatcctgcc    24120

cgccacctgc tccgcgctgc cctcggactt cgtgccgctg accttccgcg agtgcccccc    24180

gccgctgtgg agccactgct acctgctgcg cctggccaac tacctggcct accactcgga    24240

cgtgatcgag gacgtcagcg gcgagggcct gctcgagtgc cactgccgct gcaacctctg    24300

cacgccgcac cgctccctgg cctgcaaccc ccagctgctg agcgagaccc agatcatcgg    24360

caccttcgag ttgcaagggc ccagcgaggg cgagggagcc aaggggggtc tgaaactcac    24420

cccggggctg tggacctcgg cctacttgcg caagttcgtg cccgaggatt accatccctt    24480

cgagatcagg ttctacgagg accaatccca gccgcccaag gccgagctgt cggcctgcgt    24540

catcacccag ggggcgatcc tggcccaatt gcaagccatc cagaaatccc gccaagaatt    24600

cttgctgaaa aagggccgcg gggtctacct cgacccccag accggtgagg agctcaaccc    24660

cggcttcccc caggatgccc cgaggaaaca agaagctgaa agtggagctg ccgcccgtgg    24720

aggatttgga ggaagactgg gagaacagca gtcaggcaga ggagatggag gaagactggg    24780

acagcactca ggcagaggag gacagcctgc aagacagtct ggaggaagac gaggaggagg    24840

cagaggagga ggtggaagaa gcagccgccg ccagaccgtc gtcctcggcg ggggagaaag    24900

caagcagcac ggataccatc tccgctccgg gtcggggtcc cgctcggccc cacagtagat    24960

gggacgagac cgggcgattc ccgaacccca ccacccagac cggtaagaag gagcggcagg    25020

gatacaagtc ctggcggggg cacaaaaacg ccatcgtctc ctgcttgcag gcctgcgggg    25080

gcaacatctc cttcacccgg cgctacctgc tcttccaccg cggggtgaac ttcccccgca    25140

acatcttgca ttactaccgt cacctccaca gcccctacta cttccaagaa gaggcagcag    25200

cagcagaaaa agaccagaaa accagctaga aaatccacag cggcggcagc ggcaggtgga    25260

ctgaggatcg cggcgaacga gccggcgcag acccgggagc tgaggaaccg gatctttccc    25320

accctctatg ccatcttcca gcagagtcgg gggcaggagc aggaactgaa agtcaagaac    25380

cgttctctgc gctcgctcac ccgcagttgt ctgtatcaca agagcgaaga ccaacttcag    25440

cgcactctcg aggacgccga ggctctcttc aacaagtact gcgcgctcac tcttaaagag    25500

tagcccgcgc ccgcccagtc gcagaaaaag gcgggaatta cgtcacctgt gcccttcgcc    25560

ctagccgcct ccacccagca ccgccatgag caaagagatt cccacgcctt acatgtggag    25620

ctaccagccc cagatgggcc tggccgccgg cgccgcccag gactactcca cccgcatgaa    25680

ttggctcagc gccgggcccg cgatgatctc acgggtgaat gacatccgcg cccaccgaaa    25740

ccagatactc ctagaacagt cagcgctcac cgccacgccc cgcaatcacc tcaatccgcg    25800

taattggccc gccgccctgg tgtaccagga aattccccag cccacgaccg tactacttcc    25860

gcgagacgcc caggccgaag tccagctgac taactcaggt gtccagctgg cgggcggcgc    25920

caccctgtgt cgtcaccgcc ccgctcaggg tataaagcgg ctggtgatcc ggggcagagg    25980

cacacagctc aacgacgagg tggtgagctc ttcgctgggt ctgcgacctg acggagtctt    26040

ccaactcgcc ggatcgggga gatcttcctt cacgcctcgt caggcggtcc tgactttgga    26100

gagttcgtcc tcgcagcccc gctcgggcgg catcggcact ctccagttcg tggaggagtt    26160

cactccctcg gtctacttca accccttctc cggctccccc ggccactacc cggacgagtt    26220

catcccgaac tttgacgcca tcagcgagtc ggtggacggc tacgattgat taattaatca    26280

actaacccct taccccttta ccctccagta aaaataaaga ttaaaaatga ttgaattgat    26340

caataaagaa tcacttactt gaaatctgaa accaggtctc tgtccatgtt ttctgtcagc    26400

agcacttcac tcccctcttc ccaactctgg tactgcaggc cccggcgggc tgcaaacttc    26460

ctccacactc tgaaggggat gtcaaattcc tcctgtccct caatcttcat ttttatcttc    26520

tatcagatgt ccaaaaagcg cgcgcgggtg gatgatggct tcgaccccgt gtacccctac    26580

gatgcagaca acgcaccgac tgtgcccttc atcaaccctc ccttcgtctc ttcagatgga    26640

ttccaagaaa agcccctggg ggtgttgtcc ctgcgactgg ccgaccccgt caccaccaag    26700

aatggggctg tcaccctcaa gctgggggag ggggtggacc tcgacgactc gggaaaactc    26760

atctccaaaa atgccaccaa ggccactgcc cctctcagta tttccaacgg caccatttcc    26820

cttaacatgg ctgccccttt ttacaacaac aatggaacgt taagtctcaa tgtttctaca    26880

ccattagcag tatttcccac ttttaacact ttaggtatca gtcttggaaa cggtcttcaa    26940

acttctaata agttgctgac tgtacagtta actcatcctc ttacattcag ctcaaatagc    27000

atcacagtaa aaacagacaa aggactctat attaattcta gtggaaacag agggcttgag    27060

gctaacataa gcctaaaaag aggactgatt tttgatggta atgctattgc aacatacctt    27120

ggaagtggtt tagactatgg atcctatgat agcgatggga aaacaagacc catcatcacc    27180

aaaattggag caggtttgaa ttttgatgct aataatgcca tggctgtgaa gctaggcaca    27240

ggtttaagtt ttgactctgc cggtgcctta acagctggaa acaaagagga tgacaagcta    27300

acactttgga ctacacctga cccaagccct aattgtcaat tactttcaga cagagatgcc    27360

aaatttaccc tatgtcttac aaaatgcggt agtcaaatac taggcactgt tgcagtagct    27420

gctgttactg taggttcagc actaaatcca attaatgaca cagtaaaaag cgccatagta    27480

ttccttagat ttgactctga cggtgtgctc atgtcaaact catcaatggt aggtgattac    27540

tggaacttta gggaaggaca gaccacccaa agtgtggcct atacaaatgc tgtgggattc    27600

atgcccaatc taggtgcata tcctaaaacc caaagcaaaa caccaaaaaa tagtatagta    27660

agtcaggtat atttaaatgg agaaactact atgccaatga cactgacaat aactttcaat    27720

ggcactgatg aaaaagacac aacacctgtg agcacttact ccatgacttt tacatggcag    27780

tggactggag actataagga caagaatatt acctttgcta ccaactcctt tactttctcc    27840

tacatggccc aagaataaac cctgcatgcc aaccccattg ttcccaccac tatggaaaac    27900

tctgaagcag aaaaaaataa agttcaagtg ttttattgat tcaacagttt tctcacagaa    27960

ccctagtatt caacctgcca cctccctccc aacacacaga gtacacagtc ctttctcccc    28020

ggctggcctt aaaaagcatc atatcatggg taacagacat attcttaggt gttatattcc    28080

acacggtttc ctgtcgagcc aaacgctcat cagtgatatt aataaactcc ccgggcagct    28140

cacttaagtt catgtcgctg tccagctgct gagccacagg ctgctgtcca acttgcggtt    28200

gcttaacggg cggcgaagga gaagtccacg cctacatggg ggtagagtca taatcgtgca    28260

tcaggatagg gcggtggtgc tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg    28320

tcctgcagga atacaacatg gcagtggtct cctcagcgat gattcgcacc gcccgcagca    28380

taaggcgcct tgtcctccgg gcacagcagc gcaccctgat ctcacttaaa tcagcacagt    28440

aactgcagca cagcaccaca atattgttca aaatcccaca gtgcaaggcg ctgtatccaa    28500

agctcatggc ggggaccaca gaacccacgt ggccatcata ccacaagcgc aggtagatta    28560

agtggcgacc cctcataaac acgctggaca taaacattac ctcttttggc atgttgtaat    28620

tcaccacctc ccggtaccat ataaacctct gattaaacat ggcgccatcc accaccatcc    28680

taaaccagct ggccaaaacc tgcccgccgg ctatacactg cagggaaccg ggactggaac    28740

aatgacagtg gagagcccag gactcgtaac catggatcat catgctcgtc atgatatcaa    28800

tgttggcaca acacaggcac acgtgcatac acttcctcag gattacaagc tcctcccgcg    28860

ttagaaccat atcccaggga acaacccatt cctgaatcag cgtaaatccc acactgcagg    28920

gaagacctcg cacgtaactc acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg    28980

gatgatcctc cagtatggta gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac    29040

tgtacggagt gcgccgagac aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa    29100

cgccggacgt agtcatattt cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg    29160

cgtctccggt ctcgccgctt agatcgctct gtgtagtagt tgtagtatat ccactctctc    29220

aaagcatcca ggcgccccct ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc    29280

ctgataacat ccaccaccgc agaataagcc acacccagcc aacctacaca ttcgttctgc    29340

gagtcacaca cgggaggagc gggaagagct ggaagaacca tgattaactt tattccaaac    29400

ggtctcggag cacttcaaaa tgcaggtccc ggaggtggca cctctcgccc ccactgtgtt    29460

ggtggaaaat aacagccagg tcaaaggtga cacggttctc gagatgttcc acggtggctt    29520

ccagcaaagc ctccacgcgc acatccagaa acaagaggac agcgaaagcg ggagcgtttt    29580

ctaattcctc aatcatcata ttacactcct gcaccatccc cagataattt tcatttttcc    29640

agccttgaat gattcgtatt agttcctgag gtaaatccaa gccagccatg ataaaaagct    29700

cgcgcagagc gccctccacc ggcattctta agcacaccct cataattcca agagattctg    29760

ctcctggttc acctgcagca gattaacaat gggaatatca aaatctctgc cgcgatccct    29820

aagctcctcc ctcaacaata actgtatgta atctttcata tcatctccga aatttttagc    29880

catagggccg ccaggaataa gagcagggca agccacatta cagataaagc gaagtcctcc    29940

ccagtgagca ttgccaaatg taagattgaa ataagcatgc tggctagacc ctgtgatatc    30000

ttccagataa ctggacagaa aatcaggcaa gcaattttta agaaaatcaa caaaagaaaa    30060

gtcgtccagg tgcaggttta gagcctcagg aacaacgatg gaataagtgc aaggagtgcg    30120

ttccagcatg gttagtgttt ttttggtgat ctgtagaaca aaaaataaac atgcaatatt    30180

aaaccatgct agcctggcga acaggtgggt aaatcactct ttccagcacc aggcaggcta    30240

cggggtctcc ggcgcgaccc tcgtagaagc tgtcgccatg attgaaaagc atcaccgaga    30300

gaccttcccg gtggccggca tggatgattc gagaagaagc atacactccg ggaacattgg    30360

catccgtgag tgaaaaaaag cgacctataa agcctcgggg cactacaatg ctcaatctca    30420

attccagcaa agccacccca tgcggatgga gcacaaaatt ggcaggtgcg taaaaaatgt    30480

aattactccc ctcctgcaca ggcagcaaag cccccgctcc ctccagaaac acatacaaag    30540

cctcagcgtc catagcttac cgagcacggc aggcgcaaga gtcagagaaa aggctgagct    30600

ctaacctgac tgcccgctcc tgtgctcaat atatagccct aacctacact gacgtaaagg    30660

ccaaagtcta aaaatacccg ccaaaatgac acacacgccc agcacacgcc cagaaaccgg    30720

tgacacactc aaaaaaatac gtgcgcttcc tcaaacgccc aaaccggcgt catttccggg    30780

ttcccacgct acgtcaccgc tcagcgactt tcaaattccg tcgaccgtta aaaacgtcac    30840

tcgccccgcc cctaacggtc gcccttctct cggccaatca ccttcctccc ttcccaaatt    30900

caaacgcctc atttgcatat taacgcgcac aaaaagtttg aggtatatat ttgaatgatg    30960


<210>  15
<211>  44104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AZD1222 plasmid : p5713 pDEST-ChAdOx1-nCOV-19 DNA sequence

<400>  15
gcggccgcca ggcctaccca ctagtcaatt cgggaggatc gaaacggcag atcgcaaaaa       60

acagtacata cagaaggaga catgaacatg aacatcaaaa aaattgtaaa acaagccaca      120

gttctgactt ttacgactgc acttctggca ggaggagcga ctcaagcctt cgcgaaagaa      180

aataaccaaa aagcatacaa agaaacgtac ggcgtctctc atattacacg ccatgatatg      240

ctgcagatcc ctaaacagca gcaaaacgaa aaataccaag tgcctcaatt cgatcaatca      300

acgattaaaa atattgagtc tgcaaaagga cttgatgtgt gggacagctg gccgctgcaa      360

aacgctgacg gaacagtagc tgaatacaac ggctatcacg ttgtgtttgc tcttgcggga      420

agcccgaaag acgctgatga cacatcaatc tacatgtttt atcaaaaggt cggcgacaac      480

tcaatcgaca gctggaaaaa cgcgggccgt gtctttaaag acagcgataa gttcgacgcc      540

aacgatccga tcctgaaaga tcagacgcaa gaatggtccg gttctgcaac ctttacatct      600

gacggaaaaa tccgtttatt ctacactgac tattccggta aacattacgg caaacaaagc      660

ctgacaacag cgcaggtaaa tgtgtcaaaa tctgatgaca cactcaaaat caacggagtg      720

gaagatcaca aaacgatttt tgacggagac ggaaaaacat atcagaacgt tcagcagttt      780

atcgatgaag gcaattatac atccggcgac aaccatacgc tgagagaccc tcactacgtt      840

gaagacaaag gccataaata ccttgtattc gaagccaaca cgggaacaga aaacggatac      900

caaggcgaag aatctttatt taacaaagcg tactacggcg gcggcacgaa cttcttccgt      960

aaagaaagcc agaagcttca gcagagcgct aaaaaacgcg atgctgagtt agcgaacggc     1020

gccctcggta tcatagagtt aaataatgat tacacattga aaaaagtaat gaagccgctg     1080

atcacttcaa acacggtaac tgatgaaatc gagcgcgcga atgttttcaa aatgaacggc     1140

aaatggtact tgttcactga ttcacgcggt tcaaaaatga cgatcgatgg tattaactca     1200

aacgatattt acatgcttgg ttatgtatca aactctttaa ccggccctta caagccgctg     1260

aacaaaacag ggcttgtgct gcaaatgggt cttgatccaa acgatgtgac attcacttac     1320

tctcacttcg cagtgccgca agccaaaggc aacaatgtgg ttatcacaag ctacatgaca     1380

aacagaggct tcttcgagga taaaaaggca acatttgcgc caagcttctt aatgaacatc     1440

aaaggcaata aaacatccgt tgtcaaaaac agcatcctgg agcaaggaca gctgacagtc     1500

aactaataac agcaaaaaga aaatgccgat acttcattgg cattttcttt tatttctcaa     1560

caagatggtg aattgactag tgggtagatc cacaggacgg gtgtggtcgc catgatcgcg     1620

tagtcgatag tggctccaag tagcgaagcg agcaggactg ggcggcggcc aaagcggtcg     1680

gacagtgctc cgagaacggg tgcgcataga aattgcatca acgcatatag cgctagcagc     1740

acgccatagt gactggcgat gctgtcggaa tggacgatat cccgcaagag gcccggcagt     1800

accggcataa ccaagcctat gcctacagca tccagggtga cggtgccgag gatgacgatg     1860

agcgcattgt tagatttcat acacggtgcc tgactgcgtt agcaatttaa ctgtgataaa     1920

ctaccgcatt aaagcttatc gatgataagc tgtcaaacat gagaattgat ccggaaccct     1980

taatataact tcgtataatg tatgctatac gaagttatta ggtccctcga ctatagggtc     2040

accgtcgaca gcgacacact tgcatcggat gcagcccggt taacgtgccg gcacggcctg     2100

ggtaaccagg tattttgtcc acataaccgt gcgcaaaatg ttgtggataa gcaggacaca     2160

gcagcaatcc acagcaggca tacaaccgca caccgaggtt actccgttct acaggttacg     2220

acgacatgtc aatacttgcc cttgacaggc attgatggaa tcgtagtctc acgctgatag     2280

tctgatcgac aatacaagtg ggaccgtggt cccagaccga taatcagacc gacaacacga     2340

gtgggatcgt ggtcccagac taataatcag accgacgata cgagtgggac cgtggtccca     2400

gactaataat cagaccgacg atacgagtgg gaccgtggtt ccagactaat aatcagaccg     2460

acgatacgag tgggaccgtg gtcccagaca taataatcag accgaaccgt ggtcccagtc     2520

tgattatcag accgacgata cgagtgggac cgtggtccca gactaataat cagaccgacg     2580

atacgagtgg gaccgtggtc ccagactaat aatcagaccg acgatacgag tgggaccgtg     2640

gtcccagtct gattatcaga ccgacgatac aagtggaaca gtgggcccag agagaatatt     2700

caggccagtt atgctttctg gcctgtaaca aaggacatta agtaaagaca gataaacgta     2760

gactaaaacg tggtcgcatc agggtgctgg cttttcaagt tccttaagaa tggcctcaat     2820

tttctctata cactcagttg gaacacgaga cctgtccagg ttaagcacca ttttatcgcc     2880

cttatacaat actgtcgctc caggagcaaa ctgatgtcgt gagcttaaac tagttcttga     2940

tgcagatgac gttttaagca cagaagttaa aagagtgata acttcttcag cttcaaatat     3000

caccccagct tttttctgct catgaaggtt agatgcctgc tgcttaagta attcctcttt     3060

atctgtaaag gctttttgaa gtgcatcacc tgaccgggca gatagttcac cggggtgaga     3120

aaaaagagca acaactgatt taggcaattt ggcggtgttg atacagcggg taataatctt     3180

acgtgaaata ttttccgcat cagccagcgc agaaatattt ccagcaaatt cattctgcaa     3240

tcggcttgca taacgctgac cacgttcata agcacttgtt gggcgataat cgttacccaa     3300

tctggataat gcagccatct gctcatcatc cagctcgcca accagaacac gataatcact     3360

ttcggtaagt gcagcagctt tacgacggcg actcccatcg gcaatttcta tgacaccaga     3420

tactcttcga ccgaacgccg gtgtctgttg accagtcagt agaaaagaag ggatgagatc     3480

atccagtgcg tcctcagtaa gcagctcctg gtcacgttca ttacctgacc atacccgaga     3540

ggtcttctca acactatcac cccggagcac ttcaagagta aacttcacat cccgaccaca     3600

tacaggcaaa gtaatggcat taccgcgagc cattactcct acgcgcgcaa ttaacgaatc     3660

caccatcggg gcagctggtg tcgataacga agtatcttca accggttgag tattgagcgt     3720

atgttttgga ataacaggcg cacgcttcat tatctaatct cccagcgtgg tttaatcaga     3780

cgatcgaaaa tttcattgca gacaggttcc caaatagaaa gagcatttct ccaggcacca     3840

gttgaagagc gttgatcaat ggcctgttca aaaacagttc tcatccggat ctgaccttta     3900

ccaacttcat ccgtttcacg tacaacattt tttagaacca tgcttcccca ggcatcccga     3960

atttgctcct ccatccacgg ggactgagag ccattactat tgctgtattt ggtaagcaaa     4020

atacgtacat caggctcgaa ccctttaaga tcaacgttct tgagcagatc acgaagcata     4080

tcgaaaaact gcagtgcgga ggtgtagtca aacaactcag caggcgtggg aacaatcagc     4140

acatcagcag cacatacgac attaatcgtg ccgataccca ggttaggcgc gctgtcaata     4200

actatgacat catagtcatg agcaacagtt tcaatggcca gtcggagcat caggtgtgga     4260

tcggtgggca gtttaccttc atcaaatttg cccattaact cagtttcaat acggtgcaga     4320

gccagacagg aaggaataat gtcaagcccc ggccagcaag tgggctttat tgcataagtg     4380

acatcgtcct tttccccaag atagaaaggc aggagagtgt cttctgcatg aatatgaaga     4440

tctggtaccc atccgtgata cattgaggct gttccctggg ggtcgttacc ttccacgagc     4500

aaaacacgta gccccttcag agccagatcc tgagcaagat gaacagaaac tgaggttttg     4560

taaacgccac ctttatgggc agcaaccccg atcaccggtg gaaatacgtc ttcagcacgt     4620

cgcaatcgcg taccaaacac atcacgcata tgattaattt gttcaattgt ataaccaaca     4680

cgttgctcaa cccgtcctcg aatttccata tccgggtgcg gtagtcgccc tgctttctcg     4740

gcatctctga tagcctgaga agaaacccca actaaatccg ctgcttcacc tattctccag     4800

cgccgggtta ttttcctcgc ttccgggctg tcatcattaa actgtgcaat ggcgatagcc     4860

ttcgtcattt catgaccagc gtttatgcac tggttaagtg tttccatgag tttcattctg     4920

aacatccttt aatcattgct ttgcgttttt ttattaaatc ttgcaattta ctgcaaagca     4980

acaacaaaat cgcaaagtca tcaaaaaacc gcaaagttgt ttaaaataag agcaacacta     5040

caaaaggaga taagaagagc acatacctca gtcacttatt atcactagcg ctcgccgcag     5100

ccgtgtaacc gagcatagcg agcgaactgg cgaggaagca aagaagaact gttctgtcag     5160

atagctctta cgctcagcgc aagaagaaat atccaccgtg ggaaaaactc caggtagagg     5220

tacacacgcg gatagccaat tcagagtaat aaactgtgat aatcaaccct catcaatgat     5280

gacgaactaa cccccgatat caggtcacat gacgaaggga aagagaagga aatcaactgt     5340

gacaaactgc cctcaaattt ggcttcctta aaaattacag ttcaaaaagt atgagaaaat     5400

ccatgcaggc tgaaggaaac agcaaaactg tgacaaatta ccctcagtag gtcagaacaa     5460

atgtgacgaa ccaccctcaa atctgtgaca gataaccctc agactatcct gtcgtcatgg     5520

aagtgatatc gcggaaggaa aatacgatat gagtcgtctg gcggcctttc tttttctcaa     5580

tgtatgagag gcgcattgga gttctgctgt tgatctcatt aacacagacc tgcaggaagc     5640

ggcggcggaa gtcaggcata cgctggtaac tttgaggcag ctggtaacgc tctatgatcc     5700

agtcgatttt cagagagacg atgcctgagc catccggctt acgatactga cacagggatt     5760

cgtataaacg catggcatac ggattggtga tttcttttgt ttcactaagc cgaaactgcg     5820

taaaccggtt ctgtaacccg ataaagaagg gaatgagata tgggttgata tgtacactgt     5880

aaagccctct ggatggactg tgcgcacgtt tgataaacca aggaaaagat tcatagcctt     5940

tttcatcgcc ggcatcctct tcagggcgat aaaaaaccac ttccttcccc gcgaaactct     6000

tcaatgcctg ccgtatatcc ttactggctt ccgcagaggt caatccgaat atttcagcat     6060

atttagcaac atggatctcg cagataccgt catgttcctg tagggtgcca tcagattttc     6120

tgatctggtc aacgaacaga tacagcatac gtttttgatc ccgggagaga ctatatgccg     6180

cctcagtgag gtcgtttgac tggacgattc gcgggctatt tttacgtttc ttgtgattga     6240

taaccgctgt ttccgccatg acagatccat gtgaagtgtg acaagttttt agattgtcac     6300

actaaataaa aaagagtcaa taagcaggga taactttgtg aaaaaacagc ttcttctgag     6360

ggcaatttgt cacagggtta agggcaattt gtcacagaca ggactgtcat ttgagggtga     6420

tttgtcacac tgaaagggca atttgtcaca acaccttctc tagaaccagc atggataaag     6480

gcctacaagg cgctctaaaa aagaagatct aaaaactata aaaaaaataa ttataaaaat     6540

atccccgtgg ataagtggat aaccccaagg gaagtttttt caggcatcgt gtgtaagcag     6600

aatatataag tgctgttccc tggtgcttcc tcgctcactc gagggcttcg ccctgtcgct     6660

caactgcggc gagcactact ggctgtaaaa ggacagacca catcatggtt ctgtgttcat     6720

taggttgttc tgtccattgc tgacataatc cgctccactt caacgtaaca ccgcacgaag     6780

atttctattg ttcctgaagg catattcaaa tcgttttcgt taccgcttgc aggcatcatg     6840

acagaacact acttcctata aacgctacac aggctcctga gattaataat gcggatctct     6900

acgataatgg gagattttcc cgactgtttc gttcgcttct cagtggataa cagccagctt     6960

ctctgtttaa cagacaaaaa cagcatatcc actcagttcc acatttccat ataaaggcca     7020

aggcatttat tctcaggata attgtttcag catcgcaacc gcatcagact ccggcatcgc     7080

aaactgcacc cggtgccggg cagccacatc cagcgcaaaa accttcgtgt agacttccgt     7140

tgaactgatg gacttatgtc ccatcaggct ttgcagaact ttcagcggta taccggcata     7200

cagcatgtgc atcgcatagg aatggcggaa cgtatgtggt gtgaccggaa cagagaacgt     7260

cacaccgtca gcagcagcgg cggcaaccgc ctccccaatc caggtcctga ccgttctgtc     7320

cgtcacttcc cagatccgcg ctttctctgt ccttcctgtg cgacggttac gccgctccat     7380

gagcttatcg cgaataaata cctgtgacgg aagatcactt cgcagaataa ataaatcctg     7440

gtgtccctgt tgataccggg aagccctggg ccaacttttg gcgaaaatga gacgttgatc     7500

ggcacgtaag aggttccaac tttcaccata atgaaataag atcactaccg ggcgtatttt     7560

ttgagttatc gagattttca ggagctaagg aagctaaaat ggagaaaaaa atcactggat     7620

ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca tttcagtcag     7680

ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt ttaaagaccg     7740

taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc cgcctgatga     7800

atgctcatcc ggagttccgt atggcaatga aagacggtga gctggtgata tgggatagtg     7860

ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg ctctggagtg     7920

aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg gcgtgttacg     7980

gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc gtctcagcca     8040

atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac aacttcttcg     8100

cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg atgccgctgg     8160

cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg cttaatgaat     8220

tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc agttattggt     8280

gcccttaaac gcctggttgc tacgcctgaa taagtgataa taagcggatg aatggcagaa     8340

attcgatgat aagctgtcaa acatgagaat tggtcgacgg cgcgccaaag cttgcatgcc     8400

tgcagccgcg taacctggca aaatcggtta cggttgagta ataaatggat gccctgcgta     8460

agcggggcac atttcattac ctctttctcc gcacccgaca tagataataa cttcgtatag     8520

tatacattat acgaagttat ctagtagact taatcgcgtt taaacccatc atcaataata     8580

tacctcaaac tttttgtgcg cgttaatatg caaatgaggc gtttgaattt gggaagggag     8640

gaaggtgatt ggccgagaga agggcgaccg ttaggggcgg ggcgagtgac gttttgatga     8700

cgtgaccgcg aggaggagcc agtttgcaag ttctcgtggg aaaagtgacg tcaaacgagg     8760

tgtggtttga acacggaaat actcaatttt cccgcgctct ctgacaggaa atgaggtgtt     8820

tctaggcgga tgcaagtgaa aacgggccat tttcgcgcga aaactgaatg aggaagtgaa     8880

aatctgagta atttcgcgtt tatgacaggg aggagtattt gccgagggcc gagtagactt     8940

tgaccgatta cgtgggggtt tcgattaccg tgtttttcac ctaaatttcc gcgtacggtg     9000

tcaaagtccg gtgtttttac gtaggtgtca gctgatcgcc agggtattta aacctgcgct     9060

ctccagtcaa gaggccactc ttgagtgcca gcgagaagag ttttctcctc cgcgcgcgag     9120

tcagatctac actttgaaag gcgatcgcta gcgacatcga tcacaagttt gtacaaaaaa     9180

gcaggctcca ccatgggaac ccgcgttttg agatttctgt cgccgactaa attcatgtcg     9240

cgcgatagtg gtgtttatcg ccgatagaga tggcgatatt ggaaaaatcg atatttgaaa     9300

atatggcata ttgaaaatgt cgccgatgtg agtttctgtg taactgatat cgccattttt     9360

ccaaaagtga tttttgggca tacgcgatat ctggcgatag cgcttatatc gtttacgggg     9420

gatggcgata gacgactttg gtgacttggg cgattctgtg tgtcgcaaat atcgcagttt     9480

cgatataggt gacagacgat atgaggctat atcgccgata gaggcgacat caagctggca     9540

catggccaat gcatatcgat ctatacattg aatcaatatt ggccattagc catattattc     9600

attggttata tagcataaat caatattggc tattggccat tgcatacgtt gtatccatat     9660

cataatatgt acatttatat tggctcatgt ccaacattac cgccatgttg acattgatta     9720

ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag     9780

ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc     9840

ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga     9900

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat     9960

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc    10020

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct    10080

attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca    10140

cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat    10200

caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg    10260

cgtgtacggt gggaggtcta tataagcaga gctctcccta tcagtgatag agatctccct    10320

atcagtgata gagatcgtcg acgagctcgt ttagtgaacc gtcagatcgc ctggagacgc    10380

catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct ccgcggccgg    10440

gaacggtgca ttggaacgcg gattccccgt gccaagagtg acgtaagtac cgcctataga    10500

gtctataggc ccaccccctt ggcttcttat gcatgctata ctgtttttgg cttggggtct    10560

atacaccccc gcttcctcat gttataggtg atggtatagc ttagcctata ggtgtgggtt    10620

attgaccatt attgaccact cccctattgg tgacgatact ttccattact aatccataac    10680

atggctcttt gccacaactc tctttattgg ctatatgcca atacactgtc cttcagagac    10740

tgacacggac tctgtatttt tacaggatgg ggtctcattt attatttaca aattcacata    10800

tacaacacca ccgtccccag tgcccgcagt ttttattaaa cataacgtgg gatctccacg    10860

cgaatctcgg gtacgtgttc cggacatggg ctcttctccg gtagcggcgg agcttctaca    10920

tccgagccct gctcccatgc ctccagcgac tcatggtcgc tcggcagctc cttgctccta    10980

acagtggagg ccagacttag gcacagcacg atgcccacca ccaccagtgt gccgcacaag    11040

gccgtggcgg tagggtatgt gtctgaaaat gagctcgggg agcgggcttg caccgctgac    11100

gcatttggaa gacttaaggc agcggcagaa gaagatgcag gcagctgagt tgttgtgttc    11160

tgataagagt cagaggtaac tcccgttgcg gtgctgttaa cggtggaggg cagtgtagtc    11220

tgagcagtac tcgttgctgc cgcgcgcgcc accagacata atagctgaca gactaacaga    11280

ctgttccttt ccatgggtct tttctgcagt caccgtcctt gacacgaagc ttggtacctt    11340

aatggacgcc atgaagcgag gcctgtgctg tgttctgctt ctgtgtggcg ccgtgtttgt    11400

gtccgccagc caagagatcc acgccagatt tcggagattc gtgttcctgg tgctgctgcc    11460

actggtgtct agccagtgtg tgaacctgac caccaggaca cagctgcctc cagcctacac    11520

caacagcttc accagaggcg tgtactaccc agacaaggtg ttcagatcca gcgtgctgca    11580

ctctacccag gacctgttcc tgcctttctt cagcaacgtg acctggttcc acgccatcca    11640

cgtgtccggc accaatggca ccaagagatt cgacaaccca gtgctgccct tcaacgacgg    11700

agtgtacttt gccagcaccg agaagtccaa catcatcaga ggctggatct tcggcaccac    11760

actggacagc aagacccaga gcctgctgat cgtgaacaac gccaccaacg tggtcatcaa    11820

agtgtgcgag ttccagttct gcaacgaccc attcctgggc gtctactacc acaagaacaa    11880

caagagctgg atggaaagcg agttccgggt gtacagcagc gccaacaact gcaccttcga    11940

gtacgtgtcc cagcctttcc tgatggacct ggaaggcaag cagggcaact tcaagaacct    12000

gcgcgagttc gtgttcaaga acatcgacgg ctacttcaag atctacagca agcacacacc    12060

tatcaacctc gtgcgggatc tgcctcaggg cttctctgct ctggaaccac tggtggatct    12120

gcccatcggc atcaacatca cccggtttca gacactgctg gccctgcaca gaagctacct    12180

gacacctggc gatagcagct ctggatggac agctggcgcc gctgcctact atgtgggata    12240

cctgcagcct cggaccttcc tgctgaagta caacgagaac ggcaccatca ccgacgccgt    12300

ggattgtgct ctggatcctc tgagcgagac aaagtgcacc ctgaagtcct tcaccgtgga    12360

aaagggcatc taccagacca gcaacttccg ggtgcagccc accgaatcca tcgtgcggtt    12420

cccgaatatc accaatctgt gcccattcgg cgaggtgttc aatgccacca gattcgcctc    12480

tgtgtacgcc tggaaccgga agcggatcag caattgcgtg gccgactact ccgtgctgta    12540

caactccgcc agcttcagca ccttcaagtg ctacggcgtg tcacctacca agctgaacga    12600

cctgtgcttc acaaacgtgt acgccgacag cttcgtgatc cgtggagatg aagtgcggca    12660

gattgcacct ggacagacag gcaagatcgc cgactacaac tacaagctgc ccgacgactt    12720

caccggctgt gtgattgcct ggaacagcaa caacctggat agcaaagtcg gcggcaacta    12780

caattacctg taccggctgt tccggaagtc caatctgaag cccttcgagc gggacatctc    12840

caccgagatc tatcaggccg gcagcacacc ttgtaacggc gtggaaggct tcaactgcta    12900

cttcccactg cagtcctacg gctttcagcc cacaaatggc gtgggctacc agccttacag    12960

agtggtggtg ctgagcttcg agctgctgca tgctcctgcc acagtgtgcg gccctaagaa    13020

aagcaccaat ctcgtgaaga acaaatgcgt gaacttcaac ttcaacggcc tgaccggcac    13080

cggcgtgctg acagagagca acaagaagtt cctgccattc cagcagttcg gccgggatat    13140

cgccgatacc acagatgccg tcagagatcc tcagacactg gaaatcctgg acatcacacc    13200

ttgcagcttc ggcggagtgt ctgtgatcac gcctggcacc aacaccagca atcaggtggc    13260

agtgctgtac caggacgtga actgtaccga agtgcccgtg gccattcacg ccgatcagct    13320

gacacctaca tggcgggtgt actccaccgg cagcaatgtg tttcagacca gagccggctg    13380

tctgatcgga gccgagcacg tgaacaatag ctacgagtgc gacatcccta tcggcgctgg    13440

catctgcgcc tcttaccaga cacagacaaa cagccctaga cgggccagat ctgtggccag    13500

ccagagcatc attgcctaca caatgtctct gggcgccgag aacagcgtgg cctactccaa    13560

caactctatc gctatcccga ccaacttcac catcagcgtg accacagaga tcctgcctgt    13620

gtccatgacc aagaccagcg tggactgcac catgtacatc tgcggcgatt ccaccgagtg    13680

ctccaacctg ctgctgcagt acggcagctt ctgcacccag ctgaatagag ccctgacagg    13740

gatcgccgtg gaacaggaca agaacaccca agaggtgttc gcccaagtga agcagatcta    13800

caagacgcct cctatcaagg acttcggcgg cttcaatttc agccagattc tgcccgatcc    13860

tagcaagccc agcaagcgga gcttcatcga ggacctgctg ttcaacaaag tgacactggc    13920

cgacgccggc ttcatcaagc agtatggcga ttgtctgggc gacattgccg ccagggatct    13980

gatttgcgcc cagaagttta acggactgac agtgctgcct cctctgctga ccgatgagat    14040

gatcgcccag tacacatctg ccctgctggc cggcacaatc acaagcggct ggacatttgg    14100

agctggcgct gccctgcaga tcccatttgc tatgcagatg gcctaccggt tcaacggcat    14160

cggagtgacc cagaatgtgc tgtacgagaa ccagaagctg atcgccaacc agttcaacag    14220

cgccatcggc aagatccagg acagcctgag cagcacagca agcgccctgg gaaagctgca    14280

ggacgtggtc aaccagaatg cccaggcact gaacaccctg gtcaagcagc tgtctagcaa    14340

cttcggcgcc atcagctctg tgctgaacga tatcctgagc agactggaca aggtggaagc    14400

cgaggtgcag atcgacagac tgatcaccgg aaggctgcag tccctgcaga cctacgttac    14460

ccagcagctg atcagagccg ccgagattag agcctctgcc aatctggccg ccaccaagat    14520

gtctgagtgt gtgctgggcc agagcaagag agtggacttt tgcggcaagg gctaccacct    14580

gatgagcttc cctcagtctg cgcctcacgg cgtggtgttt ctgcacgtga catacgtgcc    14640

cgctcaagag aagaatttca ccaccgctcc agccatctgc cacgacggca aagcccactt    14700

tcctagagaa ggcgtgttcg tgtccaacgg cacccattgg ttcgtgaccc agcggaactt    14760

ctacgagcct cagatcatca ccaccgacaa caccttcgtg tctggcaact gcgacgtcgt    14820

gatcggcatt gtgaacaata ccgtgtacga ccctctgcag cccgagctgg acagcttcaa    14880

agaggaactg gataagtact ttaagaacca cacaagccct gacgtggacc tgggcgatat    14940

cagcggaatc aatgccagcg tcgtgaacat ccagaaagag atcgaccggc tgaacgaggt    15000

ggccaagaat ctgaacgaga gcctgatcga cctgcaagaa ctgggcaagt acgagcagta    15060

catcaagtgg ccctggtaca tctggctggg ctttatcgcc ggactgattg ccatcgtgat    15120

ggtcacaatc atgctgtgtt gcatgaccag ctgctgtagc tgcctgaagg gctgttgtag    15180

ctgtggctcc tgctgcaagt tcgacgagga cgattctgag cccgtgctga agggcgtgaa    15240

actgcactac acctgataag cggccgctcg agcatgcatc tagagggccc tattctatag    15300

tgtcacctaa atgctagagc tcgctgatca gcctcgactg tgccttctag ttgccagcca    15360

tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc    15420

ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg    15480

gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct    15540

ggggatgcgg tgggctctat ggcttctgag gcggaaagaa ccagctgggg ctcgaggggg    15600

gatcgatccg tcgagatatc tagacccagc tttcttgtac aaagtggtga tcgattcgac    15660

agatcgcgat cgcagtgagt agtgttctgg ggcgggggag gacctgcatg agggccagaa    15720

tgactgaaat ctgtgctttt ctgtgtgttg cagcatcatg agcggaagcg gctcctttga    15780

gggaggggta ttcagccctt atctgacggg gcgtctcccc tcctgggcgg gagtgcgtca    15840

gaatgtgatg ggatccacgg tggacggccg gcccgtgcag cccgcgaact cttcaaccct    15900

gacctatgca accctgagct cttcgtcggt ggacgcagct gccgccgcag ctgctgcatc    15960

cgccgccagc gccgtgcgcg gaatggccat gggcgccggc tactacggca ctctggtggc    16020

caactcgagt tccaccaata atcccgccag cctgaacgag gagaagctgc tgctgctgat    16080

ggcccagctt gaggccttga cccagcgcct gggcgagctg acccagcagg tggctcagct    16140

gcaggagcag acgcgggccg cggttgccac ggtgaaatcc aaataaaaaa tgaatcaata    16200

aataaacgga gacggttgtt gattttaaca cagagtctga atctttattt gatttttcgc    16260

gcgcggtagg ccctggacca ccggtctcga tcattgagca cccggtggat cttttccagg    16320

acccggtaga ggtgggcttg gatgttgagg tacatgggca tgagcccgtc ccgggggtgg    16380

aggtagctcc attgcagggc ctcgtgctcg ggggtggtgt tgtaaatcac ccagtcatag    16440

caggggcgca gggcgtggtg ttgcacaata tctttgagga ggagactgat ggccacgggc    16500

agccctttgg tgtaggtgtt tacaaatctg ttgagctggg agggatgcat gcggggggag    16560

atgaggtgca tcttggcctg gatcttgaga ttggcgatgt taccgcccag atcccgcctg    16620

gggttcatgt tgtgcaggac caccagcacg gtgtatccgg tgcacttggg gaatttatca    16680

tgcaacttgg aagggaaggc gtgaaagaat ttggcgacgc ccttgtgtcc gcccaggttt    16740

tccatgcact catccatgat gatggcaatg ggcccgtggg cggcggcctg ggcaaagacg    16800

tttcgggggt cggacacatc atagttgtgg tcctgggtga ggtcatcata ggccatttta    16860

atgaatttgg ggcggagggt gccggactgg gggacaaagg taccctcgat cccgggggcg    16920

tagttcccct cacagatctg catctcccag gctttgagct cagagggggg gatcatgtcc    16980

acctgcgggg cgataaagaa cacggtttcc ggggcggggg agatgagctg ggccgaaagc    17040

aagttccgga gcagctggga cttgccgcag ccggtggggc cgtaaatgac cccgatgacc    17100

ggctgcaggt ggtagttgag ggagagacag ctgccgtcct cccggaggag gggggccacc    17160

tcgttcatca tctcgcgcac gtgcatgttc tcgcgcacca gttccgccag gaggcgctct    17220

ccccccagag ataggagctc ctggagcgag gcgaagtttt tcagcggctt gagtccgtcg    17280

gccatgggca ttttggagag ggtctgttgc aagagttcca agcggtccca gagctcggtg    17340

atgtgctcta cggcatctcg atccagcaga cctcctcgtt tcgcgggttg ggacgactgc    17400

gggagtaggg caccagacga tgggcgtcca gcgcagccag ggtccggtcc ttccagggcc    17460

gcagcgtccg cgtcagggtg gtctccgtca cggtgaaggg gtgcgcgccg ggctgggcgc    17520

ttgcgagggt gcgcttcagg ctcatccggc tggtcgaaaa ccgctcccga tcggcgccct    17580

gcgcgtcggc caggtagcaa ttgaccatga gttcgtagtt gagcgcctcg gccgcgtggc    17640

ctttggcgcg gagcttacct ttggaagtct gcccgcaggc gggacagagg agggacttga    17700

gggcgtagag cttgggggcg aggaagacgg aatcgggggc gtaggcgtcc gcgccgcagt    17760

gggcgcagac ggtctcgcac tccacgagcc aggtgaggtc gggctggtcg gggtcaaaaa    17820

ccagtttccc gccgttcttt ttgatgcgtt tcttaccttt ggtctccatg agctcgtgtc    17880

cccgctgggt gacaaagagg ctgtccgtgt ccccgtagac cgactttatg ggccggtcct    17940

cgagcggtgt gccgcggtcc tcctcgtaga ggaaccccgc ccactccgag acgaaagccc    18000

gggtccaggc cagcacgaag gaggccacgt gggacgggta gcggtcgttg tccaccagcg    18060

ggtccacttt ttccagggta tgcaaacaca tgtccccctc gtccacatcc aggaaggtga    18120

ttggcttgta agtgtaggcc acgtgaccgg gggtcccggc cgggggggta taaaaggggg    18180

cgggcccctg ctcgtcctca ctgtcttccg gatcgctgtc caggagcgcc agctgttggg    18240

gtaggtattc cctctcgaag gcgggcatga cctcggcact caggttgtca gtttctagaa    18300

acgaggagga tttgatattg acggtgccag cggagatgcc tttcaagagc ccctcgtcca    18360

tctggtcaga aaagacgatt tttttgttgt cgagcttggt ggcgaaggag ccgtagaggg    18420

cgttggaaag gagcttggcg atggagcgca tggtctggtt tttttccttg tcggcgcgct    18480

ccttggccgc gatgttgagc tgcacgtact cgcgcgccac gcacttccat tcggggaaga    18540

cggtggtcat ctcgtcgggc acgattctga cctgccaacc tcgattatgc agggtgatga    18600

ggtccacact ggtggccacc tcgccgcgca ggggctcgtt ggtccagcag aggcggccgc    18660

ccttgcgcga gcagaagggg ggcagagggt ccagcatgac ctcgtcgggg gggtcggcat    18720

cgatggtgaa gatgccgggc aggagatcgg ggtcgaagta gctgatggaa gtggccagat    18780

cgtccaggga agcttgccat tcgcgcacgg ccagcgcgcg ctcgtaggga ctgaggggcg    18840

tgccccaggg catggggtgg gtgagcgcgg aggcgtacat gccgcagatg tcgtagacgt    18900

agaggggctc ctcgaggatg ccgatgtagg tggggtagca gcgccccccg cggatgctgg    18960

cgcgcacgta gtcatacagc tcgtgcgagg gcgcgaggag ccccgggccc aggttggtgc    19020

gactgggctt ttcggcgcgg tagacgatct ggcgaaagat ggcatgcgag ttggaggaga    19080

tggtgggcct ttggaagatg ttgaagtggg cgtgggggag gccgaccgag tcgcggatga    19140

agtgggcgta ggagtcttgc agtttggcga cgagctcggc ggtgacgagg acgtccagag    19200

cgcagtagtc gagggtctcc tggatgatgt catacttgag ctggcccttt tgtttccaca    19260

gctcgcggtt gagaaggaac tcttcgcggt ccttccagta ctcttcgagg gggaacccgt    19320

cctgatctgc acggtaagag cctagcatgt agaactggtt gacggccttg taggcgcagc    19380

agcccttctc cacggggagg gcgtaggcct gggcggcctt gcgcagggag gtgtgcgtga    19440

gggcgaaggt gtccctgacc atgaccttga ggaactggtg cttgaaatcg atatcgtcgc    19500

agcccccctg ctcccagagc tggaagtccg tgcgcttctt gtaggcgggg ttgggcaaag    19560

cgaaagtaac atcgttgaaa aggatcttgc ccgcgcgggg cataaagttg cgagtgatgc    19620

ggaaaggctg gggcacctcg gcccggttgt tgatgacctg ggcggcgagc acgatctcgt    19680

cgaaaccgtt gatgttgtgg cccacgatgt agagttccac gaatcgcggg cggcccttga    19740

cgtggggcag cttcttgagc tcctcgtagg tgagctcgtc ggggtcgctg agaccgtgct    19800

gctcgagcgc ccagtcggcg agatgggggt tggcgcggag gaaggaagtc cagagatcca    19860

cggccagggc ggtttgcaga cggtcccggt actgacggaa ctgctgcccg acggccattt    19920

tttcgggggt gacgcagtag aaggtgcggg ggtccccgtg ccagcggtcc catttgagct    19980

ggagggcgag atcgagggcg agctcgacga ggcggtcgtc ccctgagagt ttcatgacca    20040

gcatgaaggg gacgagctgc ttgccgaagg accccatcca ggtgtaggtt tccacatcgt    20100

aggtgaggaa gagcctttcg gtgcgaggat gcgagccgat ggggaagaac tggatctcct    20160

gccaccaatt ggaggaatgg ctgttgatgt gatggaagta gaaatgccga cggcgcgccg    20220

aacactcgtg cttgtgttta tacaagcggc cacagtgctc gcaacgctgc acgggatgca    20280

cgtgctgcac gagctgtacc tgagttcctt tgacgaggaa tttcagtggg aagtggagtc    20340

gtggcgcctg catctcgtgc tgtactacgt cgtggtggtc ggcctggccc tcttctgcct    20400

cgatggtggt catgctgacg agcccgcgcg ggaggcaggt ccagacctcg gcgcgagcgg    20460

gtcggagagc gaggacgagg gcgcgcaggc cggagctgtc cagggtcctg agacgctgcg    20520

gagtcaggtc agtgggcagc ggcggcgcgc ggttgacttg caggagtttt tccagggcgc    20580

gcgggaggtc cagatggtac ttgatctcca ccgcgccgtt ggtggcgacg tcgatggctt    20640

gcagggtccc gtgcccctgg ggtgtgacca ccgtcccccg tttcttcttg ggcggctggg    20700

gcgacggggg cggtgcctct tccatggtta gaagcggcgg cgaggacgcg cgccgggcgg    20760

cagaggcggc tcggggcccg gaggcagggg cggcaggggc acgtcggcgc cgcgcgcggg    20820

taggttctgg tactgcgccc ggagaagact ggcgtgagcg acgacgcgac ggttgacgtc    20880

ctggatctga cgcctctggg tgaaggccac gggacccgtg agtttgaacc tgaaagagag    20940

ttcgacagaa tcaatctcgg tatcgttgac ggcggcctgc cgcaggatct cttgcacgtc    21000

gcccgagttg tcctggtagg cgatctcggt catgaactgc tcgatctcct cctcctgaag    21060

gtctccgcga ccggcgcgct ccacggtggc cgcgaggtcg ttggagatgc ggcccatgag    21120

ctgcgagaag gcgttcatgc ccgcctcgtt ccagacgcgg ctgtagacca cgacgccctc    21180

gggatcgcgg gcgcgcatga ccacctgggc gaggttgagc tccacgtggc gcgtgaagac    21240

cgcgtagttg cagaggcgct ggtagaggta gttgagcgtg gtggcgatgt gctcggtgac    21300

gaagaaatac atgatccagc ggcggagcgg catctcgctg acgtcgccca gcgcctccaa    21360

gcgttccatg gcctcgtaaa agtccacggc gaagttgaaa aactgggagt tgcgcgccga    21420

gacggtcaac tcctcctcca gaagacggat gagctcggcg atggtggcgc gcacctcgcg    21480

ctcgaaggcc cccgggagtt cctccacttc ctcctcttct tcctcctcca ctaacatctc    21540

ttctacttcc tcctcaggcg gtggtggtgg cgggggaggg ggcctgcgtc gccggcggcg    21600

cacgggcaga cggtcgatga agcgctcgat ggtctcgccg cgccggcgtc gcatggtctc    21660

ggtgacggcg cgcccgtcct cgcggggccg cagcgtgaag acgccgccgc gcatctccag    21720

gtggccgggg gggtccccgt tgggcaggga gagggcgctg acgatgcatc ttatcaattg    21780

ccccgtaggg actccgcgca aggacctgag cgtctcgaga tccacgggat ctgaaaaccg    21840

ttgaacgaag gcttcgagcc agtcgcagtc gcaaggtagg ctgagcacgg tttcttctgc    21900

cgggtcatgt tggggagcgg ggcgggcgat gctgctggtg atgaagttga aataggcggt    21960

tctgagacgg cggatggtgg cgaggagcac caggtctttg ggcccggctt gctggatgcg    22020

cagacggtcg gccatgcccc aggcgtggtc ctgacacctg gccaggtcct tgtagtagtc    22080

ctgcatgagc cgctccacgg gcacctcctc ctcgcccgcg cggccgtgca tgcgcgtgag    22140

cccgaagccg cgctggggct ggacgagcgc caggtcggcg acgacgcgct cggcgaggat    22200

ggcctgctgg atctgggtga gggtggtctg gaagtcgtca aagtcgacga agcggtggta    22260

ggctccggtg ttgatggtgt aggagcagtt ggccatgacg gaccagttga cggtctggtg    22320

gcccggacgc acgagctcgt ggtacttgag gcgcgagtag gcgcgcgtgt cgaagatgta    22380

gtcgttgcag gtgcgcacca ggtactggta gccgatgagg aagtgcggcg gcggctggcg    22440

gtagagcggc catcgctcgg tggcgggggc gccgggcgcg aggtcctcga gcatggtgcg    22500

gtggtagccg tagatgtacc tggacatcca ggtgatgccg gcggcggtgg tggaggcgcg    22560

cgggaactcg cggacgcggt tccagatgtt gcgcagcggc aggaagtagt tcatggtggg    22620

cacggtctgg cccgtgaggc gcgcgcagtc gtggatgctc tatacgggca aaaacgaaag    22680

cggtcagcgg ctcgactccg tggcctggag gctaagcgaa cgggttgggc tgcgcgtgta    22740

ccccggttcg aatctcgaat caggctggag ccgcagctaa cgtggtactg gcactcccgt    22800

ctcgacccaa gcctgcacca accctccagg atacggaggc gggtcgtttt gcaacttttt    22860

ttggaggccg gaaatgaaac tagtaagcgc ggaaagcggc cgaccgcgat ggctcgctgc    22920

cgtagtctgg agaagaatcg ccagggttgc gttgcggtgt gccccggttc gaggccggcc    22980

ggattccgcg gctaacgagg gcgtggctgc cccgtcgttt ccaagacccc atagccagcc    23040

gacttctcca gttacggagc gagcccctct tttgttttgt ttgtttttgc cagatgcatc    23100

ccgtactgcg gcagatgcgc ccccaccacc ctccaccgca acaacagccc cctcctccac    23160

agccggcgct tctgcccccg ccccagcagc agcagcaact tccagccacg accgccgcgg    23220

ccgccgtgag cggggctgga cagacttctc agtatgatca cctggccttg gaagagggcg    23280

aggggctggc gcgcctgggg gcgtcgtcgc cggagcggca cccgcgcgtg cagatgaaaa    23340

gggacgctcg cgaggcctac gtgcccaagc agaacctgtt cagagacagg agcggcgagg    23400

agcccgagga gatgcgcgcg gcccggttcc acgcggggcg ggagctgcgg cgcggcctgg    23460

accgaaagag ggtgctgagg gacgaggatt tcgaggcgga cgagctgacg gggatcagcc    23520

ccgcgcgcgc gcacgtggcc gcggccaacc tggtcacggc gtacgagcag accgtgaagg    23580

aggagagcaa cttccaaaaa tccttcaaca accacgtgcg caccctgatc gcgcgcgagg    23640

aggtgaccct gggcctgatg cacctgtggg acctgctgga ggccatcgtg cagaacccca    23700

ccagcaagcc gctgacggcg cagctgttcc tggtggtgca gcatagtcgg gacaacgagg    23760

cgttcaggga ggcgctgctg aatatcaccg agcccgaggg ccgctggctc ctggacctgg    23820

tgaacattct gcagagcatc gtggtgcagg agcgcgggct gccgctgtcc gagaagctgg    23880

cggccatcaa cttctcggtg ctgagtctgg gcaagtacta cgctaggaag atctacaaga    23940

ccccgtacgt gcccatagac aaggaggtga agatcgacgg gttttacatg cgcatgaccc    24000

tgaaagtgct gaccctgagc gacgatctgg gggtgtaccg caacgacagg atgcaccgcg    24060

cggtgagcgc cagcaggcgg cgcgagctga gcgaccagga gctgatgcac agcctgcagc    24120

gggccctgac cggggccggg accgaggggg agagctactt tgacatgggc gcggacctgc    24180

actggcagcc cagccgccgg gccttggagg cggcaggcgg tcccccctac atagaagagg    24240

tggacgatga ggtggacgag gagggcgagt acctggaaga ctgatggcgc gaccgtattt    24300

ttgctagatg caacaacagc cacctcctga tcccgcgatg cgggcggcgc tgcagagcca    24360

gccgtccggc attaactcct cggacgattg gacccaggcc atgcaacgca tcatggcgct    24420

gacgacccgc aaccccgaag cctttagaca gcagccccag gccaaccggc tctcggccat    24480

cctggaggcc gtggtgccct cgcgctccaa ccccacgcac gagaaggtcc tggccatcgt    24540

gaacgcgctg gtggagaaca aggccatccg cggcgacgag gccggcctgg tgtacaacgc    24600

gctgctggag cgcgtggccc gctacaacag caccaacgtg cagaccaacc tggaccgcat    24660

ggtgaccgac gtgcgcgagg ccgtggccca gcgcgagcgg ttccaccgcg agtccaacct    24720

gggatccatg gtggcgctga acgccttcct cagcacccag cccgccaacg tgccccgggg    24780

ccaggaggac tacaccaact tcatcagcgc cctgcgcctg atggtgaccg aggtgcccca    24840

gagcgaggtg taccagtccg ggccggacta cttcttccag accagtcgcc agggcttgca    24900

gaccgtgaac ctgagccagg cgttcaagaa cttgcagggc ctgtggggcg tgcaggcccc    24960

ggtcggggac cgcgcgacgg tgtcgagcct gctgacgccg aactcgcgcc tgctgctgct    25020

gctggtggcc cccttcacgg acagcggcag catcaaccgc aactcgtacc tgggctacct    25080

gattaacctg taccgcgagg ccatcggcca ggcgcacgtg gacgagcaga cctaccagga    25140

gatcacccac gtgagccgcg ccctgggcca ggacgacccg ggcaatctgg aagccaccct    25200

gaactttttg ctgaccaacc ggtcgcagaa gatcccgccc cagtacacgc tcagcgccga    25260

ggaggagcgc atcctgcgat acgtgcagca gagcgtgggc ctgttcctga tgcaggaggg    25320

ggccaccccc agcgccgcgc tcgacatgac cgcgcgcaac atggagccca gcatgtacgc    25380

cagcaaccgc ccgttcatca ataaactgat ggactacttg catcgggcgg ccgccatgaa    25440

ctctgactat ttcaccaacg ccatcctgaa tccccactgg ctcccgccgc cggggttcta    25500

cacgggcgag tacgacatgc ccgaccccaa tgacgggttc ctgtgggacg atgtggacag    25560

cagcgtgttc tccccccgac cgggtgctaa cgagcgcccc ttgtggaaga aggaaggcag    25620

cgaccgacgc ccgtcctcgg cgctgtccgg ccgcgagggt gctgccgcgg cggtgcccga    25680

ggccgccagt cctttcccga gcttgccctt ctcgctgaac agtattcgca gcagcgagct    25740

gggcaggatc acgcgcccgc gcttgctggg cgaggaggag tacttgaatg actcgctgtt    25800

gagacccgag cgggagaaga acttccccaa taacgggata gagagcctgg tggacaagat    25860

gagccgctgg aagacgtatg cgcaggagca cagggacgat ccgtcgcagg gggccacgag    25920

ccggggcagc gccgcccgta aacgccggtg gcacgacagg cagcggggac tgatgtggga    25980

cgatgaggat tccgccgacg acagcagcgt gttggacttg ggtgggagtg gtaacccgtt    26040

cgctcacctg cgcccccgca tcgggcgcat gatgtaagag aaaccgaaaa taaatgatac    26100

tcaccaaggc catggcgacc agcgtgcgtt cgtttcttct ctgttgttgt atctagtatg    26160

atgaggcgtg cgtacccgga gggtcctcct ccctcgtacg agagcgtgat gcagcaggcg    26220

atggcggcgg cggcggcgat gcagcccccg ctggaggctc cttacgtgcc cccgcggtac    26280

ctggcgccta cggaggggcg gaacagcatt cgttactcgg agctggcacc cttgtacgat    26340

accacccggt tgtacctggt ggacaacaag tcggcggaca tcgcctcgct gaactaccag    26400

aacgaccaca gcaacttcct gaccaccgtg gtgcagaaca atgacttcac ccccacggag    26460

gccagcaccc agaccatcaa ctttgacgag cgctcgcggt ggggcggtca gctgaaaacc    26520

atcatgcaca ccaacatgcc caacgtgaac gagttcatgt acagcaacaa gttcaaggcg    26580

cgggtgatgg tctcccgcaa gacccccaac ggggtgacag tgacagatgg tagtcaggat    26640

atcttggagt atgaatgggt ggagtttgag ctgcccgaag gcaacttctc ggtgaccatg    26700

accatcgacc tgatgaacaa cgccatcatc gacaattact tggcggtggg gcggcagaac    26760

ggggtcctgg agagcgatat cggcgtgaag ttcgacacta ggaacttcag gctgggctgg    26820

gaccccgtga ccgagctggt catgcccggg gtgtacacca acgaggcctt ccaccccgat    26880

attgtcttgc tgcccggctg cggggtggac ttcaccgaga gccgcctcag caacctgctg    26940

ggcattcgca agaggcagcc cttccaggag ggcttccaga tcatgtacga ggatctggag    27000

gggggcaaca tccccgcgct cctggatgtc gacgcctatg agaaaagcaa ggaggagagc    27060

gccgccgcgg cgactgcagc tgtagccacc gcctctaccg aggtcagggg cgataatttt    27120

gccagccctg cagcagtggc agcggccgag gcggctgaaa ccgaaagtaa gatagtcatt    27180

cagccggtgg agaaggatag caaggacagg agctacaacg tgctgccgga caagataaac    27240

accgcctacc gcagctggta cctggcctac aactatggcg accccgagaa gggcgtgcgc    27300

tcctggacgc tgctcaccac ctcggacgtc acctgcggcg tggagcaagt ctactggtcg    27360

ctgcccgaca tgatgcaaga cccggtcacc ttccgctcca cgcgtcaagt tagcaactac    27420

ccggtggtgg gcgccgagct cctgcccgtc tactccaaga gcttcttcaa cgagcaggcc    27480

gtctactcgc agcagctgcg cgccttcacc tcgctcacgc acgtcttcaa ccgcttcccc    27540

gagaaccaga tcctcgtccg cccgcccgcg cccaccatta ccaccgtcag tgaaaacgtt    27600

cctgctctca cagatcacgg gaccctgccg ctgcgcagca gtatccgggg agtccagcgc    27660

gtgaccgtta ctgacgccag acgccgcacc tgcccctacg tctacaaggc cctgggcata    27720

gtcgcgccgc gcgtcctctc gagccgcacc ttctaaaaaa tgtccattct catctcgccc    27780

agtaataaca ccggttgggg cctgcgcgcg cccagcaaga tgtacggagg cgctcgccaa    27840

cgctccacgc aacaccccgt gcgcgtgcgc gggcacttcc gcgctccctg gggcgccctc    27900

aagggccgcg tgcggtcgcg caccaccgtc gacgacgtga tcgaccaggt ggtggccgac    27960

gcgcgcaact acacccccgc cgccgcgccc gtctccaccg tggacgccgt catcgacagc    28020

gtggtggccg acgcgcgccg gtacgcccgc gccaagagcc ggcggcggcg catcgcccgg    28080

cggcaccgga gcacccccgc catgcgcgcg gcgcgagcct tgctgcgcag ggccaggcgc    28140

acgggacgca gggccatgct cagggcggcc agacgcgcgg cttcaggcgc cagcgccggc    28200

aggacccgga gacgcgcggc cacggcggcg gcagcggcca tcgccagcat gtcccgcccg    28260

cggcgaggga acgtgtactg ggtgcgcgac gccgccaccg gtgtgcgcgt gcccgtgcgc    28320

acccgccccc ctcgcacttg aagatgttca cttcgcgatg ttgatgtgtc ccagcggcga    28380

ggaggatgtc caagcgcaaa ttcaaggaag agatgctcca ggtcatcgcg cctgagatct    28440

acggccccgc ggtggtgaag gaggaaagaa agccccgcaa aatcaagcgg gtcaaaaagg    28500

acaaaaagga agaagatgac gatctggtgg agtttgtgcg cgagttcgcc ccccggcggc    28560

gcgtgcagtg gcgcgggcgg aaagtgcacc cggtgctgag acccggcacc accgtggtct    28620

tcacgcccgg cgagcgctcc ggcagcgctt ccaagcgctc ctacgacgag gtgtacgggg    28680

acgaggacat cctcgagcag gcggccgagc gcctgggcga gtttgcttac ggcaagcgca    28740

gccgccccgc cctgaaggaa gaggcggtgt ccatcccgct ggaccacggc aaccccacgc    28800

cgagcctcaa gcccgtgacc ctgcagcagg tgctgccgag cgcagcgccg cgccgggggt    28860

tcaagcgcga gggcgaggat ctgtacccca ccatgcagct gatggtgccc aagcgccaga    28920

agctggaaga cgtgctggag accatgaagg tggacccgga cgtgcagccc gaggtcaagg    28980

tgcggcccat caagcaggtg gccccgggcc tgggcgtgca gaccgtggac atcaagatcc    29040

ccacggagcc catggaaacg cagaccgagc ccatgatcaa gcccagcacc agcaccatgg    29100

aggtgcagac ggatccctgg atgccatcgg ctcctagccg aagaccccgg cgcaagtacg    29160

gcgcggccag cctgctgatg cccaactacg cgctgcatcc ttccatcatc cccacgccgg    29220

gctaccgcgg cacgcgcttc taccgcggtc atacaaccag ccgccgccgc aagaccacca    29280

cccgccgccg ccgtcgccgc acagccgctg catctacccc tgccgccctg gtgcggagag    29340

tgtaccgccg cggccgcgcg cctctgaccc taccgcgcgc gcgctaccac ccgagcatcg    29400

ccatttaaac tttcgcctgc tttgcagatg gccctcacat gccgcctccg cgttcccatt    29460

acgggctacc gaggaagaaa accgcgccgt agaaggctgg cggggaacgg gatgcgtcgc    29520

caccaccatc ggcggcggcg cgccatcagc aagcggttgg ggggaggctt cctgcccgcg    29580

ctgatcccca tcatcgccgc ggcgatcggg gcgatccccg gcattgcttc cgtggcggtg    29640

caggcctctc agcgccactg agacacttgg aaaacatctt gtaataaacc aatggactct    29700

gacgctcctg gtcctgtgat gtgttttcgt agacagatgg aagacatcaa tttttcgtcc    29760

ctggctccgc gacacggcac gcggccgttc atgggcacct ggagcgacat cggcaccagc    29820

caactgaacg ggggcgcctt caattggagc agtctctgga gcgggcttaa gaatttcggg    29880

tccacgctta aaacctatgg cagcaaggcg tggaacagca ccacagggca ggcgctgagg    29940

gataagctga aagagcagaa cttccagcag aaggtggtcg atgggctcgc ctcgggcatc    30000

aacggggtgg tggacctggc caaccaggcc gtgcagcggc agatcaacag ccgcctggac    30060

ccggtgccgc ccgccggctc cgtggagatg ccgcaggtgg aggaggagct gcctcccctg    30120

gacaagcggg gcgagaagcg accccgcccc gacgcggagg agacgctgct gacgcacacg    30180

gacgagccgc ccccgtacga ggaggcggtg aaactgggtc tgcccaccac gcggcccatc    30240

gcgcccctgg ccaccggggt gctgaaaccc gaaagtaata agcccgcgac cctggacttg    30300

cctcctcccg cttcccgccc ctctacagtg gctaagcccc tgccgccggt ggccgtggcc    30360

cgcgcgcgac ccgggggctc cgcccgccct catgcgaact ggcagagcac tctgaacagc    30420

atcgtgggtc tgggagtgca gagtgtgaag cgccgccgct gctattaaac ctaccgtagc    30480

gcttaacttg cttgtctgtg tgtgtatgta ttatgtcgcc gctgtccgcc agaaggagga    30540

gtgaagaggc gcgtcgccga gttgcaagat ggccacccca tcgatgctgc cccagtgggc    30600

gtacatgcac atcgccggac aggacgcttc ggagtacctg agtccgggtc tggtgcagtt    30660

cgcccgcgcc acagacacct acttcagtct ggggaacaag tttaggaacc ccacggtggc    30720

gcccacgcac gatgtgacca ccgaccgcag ccagcggctg acgctgcgct tcgtgcccgt    30780

ggaccgcgag gacaacacct actcgtacaa agtgcgctac acgctggccg tgggcgacaa    30840

ccgcgtgctg gacatggcca gcacctactt tgacatccgc ggcgtgctgg atcggggccc    30900

tagcttcaaa ccctactccg gcaccgccta caacagcctg gctcccaagg gagcgcccaa    30960

ttccagccag tgggagcaaa aaaaggcagg caatggtgac actatggaaa cacacacatt    31020

tggtgtggcc ccaatgggcg gtgagaatat tacaatcgac ggattacaaa ttggaactga    31080

cgctacagct gatcaggata aaccaattta tgctgacaaa acattccagc ctgaacctca    31140

agtaggagaa gaaaattggc aagaaactga aagcttttat ggcggtaggg ctcttaaaaa    31200

agacacaagc atgaaacctt gctatggctc ctatgctaga cccaccaatg taaagggagg    31260

tcaagctaaa cttaaagttg gagctgatgg agttcctacc aaagaatttg acatagacct    31320

ggctttcttt gatactcccg gtggcacagt gaatggacaa gatgagtata aagcagacat    31380

tgtcatgtat accgaaaaca cgtatctgga aactccagac acgcatgtgg tatacaaacc    31440

aggcaaggat gatgcaagtt ctgaaattaa cctggttcag cagtccatgc ccaatagacc    31500

caactatatt gggttcagag acaactttat tgggctcatg tattacaaca gtactggcaa    31560

tatgggggtg ctggctggtc aggcctcaca gctgaatgct gtggtcgact tgcaagacag    31620

aaacaccgag ctgtcatacc agctcttgct tgactctttg ggtgacagaa cccggtattt    31680

cagtatgtgg aatcaggcgg tggacagtta tgatcctgat gtgcgcatta ttgaaaacca    31740

tggtgtggaa gacgaacttc ccaactattg cttccccctg gatgggtctg gcactaatgc    31800

cgcttaccaa ggtgtgaaag taaaaaatgg taacgatggt gatgttgaga gcgaatggga    31860

aaatgatgat actgtcgcag ctcgaaatca attatgcaag ggcaacattt ttgccatgga    31920

aattaacctc caagccaacc tgtggagaag tttcctctac tcgaacgtgg ccctgtacct    31980

gcccgactct tacaagtaca cgccagccaa catcaccctg cccaccaaca ccaacactta    32040

tgattacatg aacgggagag tggtgcctcc ctcgctggtg gacgcctaca tcaacatcgg    32100

ggcgcgctgg tcgctggacc ccatggacaa cgtcaatccc ttcaaccacc accgcaacgc    32160

gggcctgcgc taccgctcca tgctcctggg caacgggcgc tacgtgccct tccacatcca    32220

ggtgccccag aaatttttcg ccatcaagag cctcctgctc ctgcccgggt cctacaccta    32280

cgagtggaac ttccgcaagg acgtcaacat gatcctgcag agctccctcg gcaacgacct    32340

gcgcacggac ggggcctcca tctccttcac cagcatcaac ctctacgcca ccttcttccc    32400

catggcgcac aacacggcct ccacgctcga ggccatgctg cgcaacgaca ccaacgacca    32460

gtccttcaac gactacctct cggcggccaa catgctctac cccatcccgg ccaacgccac    32520

caacgtgccc atctccatcc cctcgcgcaa ctgggccgcc ttccgcggct ggtccttcac    32580

gcgcctcaag accaaggaga cgccctcgct gggctccggg ttcgacccct acttcgtcta    32640

ctcgggctcc atcccctacc tcgacggcac cttctacctc aaccacacct tcaagaaggt    32700

ctccatcacc ttcgactcct ccgtcagctg gcccggcaac gaccggctcc tgacgcccaa    32760

cgagttcgaa atcaagcgca ccgtcgacgg cgagggatac aacgtggccc agtgcaacat    32820

gaccaaggac tggttcctgg tccagatgct ggcccactac aacatcggct accagggctt    32880

ctacgtgccc gagggctaca aggaccgcat gtactccttc ttccgcaact tccagcccat    32940

gagccgccag gtggtggacg aggtcaacta caaggactac caggccgtca ccctggccta    33000

ccagcacaac aactcgggct tcgtcggcta cctcgcgccc accatgcgcc agggccagcc    33060

ctaccccgcc aactacccgt acccgctcat cggcaagagc gccgtcacca gcgtcaccca    33120

gaaaaagttc ctctgcgaca gggtcatgtg gcgcatcccc ttctccagca acttcatgtc    33180

catgggcgcg ctcaccgacc tcggccagaa catgctctat gccaactccg cccacgcgct    33240

agacatgaat ttcgaagtcg accccatgga tgagtccacc cttctctatg ttgtcttcga    33300

agtcttcgac gtcgtccgag tgcaccagcc ccaccgcggc gtcatcgagg ccgtctacct    33360

gcgcaccccc ttctcggccg gtaacgccac cacctaaatt gctacttgca tgatggctga    33420

gcccacaggc tccggcgagc aggagctcag ggccatcatc cgcgacctgg gctgcgggcc    33480

ctacttcctg ggcaccttcg ataagcgctt cccgggattc atggccccgc acaagctggc    33540

ctgcgccatc gtcaacacgg ccggccgcga gaccgggggc gagcactggc tggccttcgc    33600

ctggaacccg cgctcgaaca cctgctacct cttcgacccc ttcgggttct cggacgagcg    33660

cctcaagcag atctaccagt tcgagtacga gggcctgctg cgccgtagcg ccctggccac    33720

cgaggaccgc tgcgtcaccc tggaaaagtc cacccagacc gtgcagggtc cgcgctcggc    33780

cgcctgcggg ctcttctgct gcatgttcct gcacgccttc gtgcactggc ccgaccgccc    33840

catggacaag aaccccacca tgaacttgct gacgggggtg cccaacggca tgctccagtc    33900

gccccaggtg gaacccaccc tgcgccgcaa ccaggaggcg ctctaccgct tcctcaactc    33960

ccactccgcc tactttcgct cccaccgcgc gcgcatcgag aaggccaccg ccttcgaccg    34020

catgaacaat caagacatgt aaaccgtgtg tgtatgttta aaatatcttt taataaacag    34080

cactttaatg ttacacatgc atctgagatg attttatttt agaaatcgaa agggttctgc    34140

cgggtctcgg catggcccgc gggcagggac acgttgcgga actggtactt ggccagccac    34200

ttgaactcgg ggatcagcag tttgggcagc ggggtgtcgg ggaaggagtc ggtccacagc    34260

ttccgcgtca gctgcagggc gcccagcagg tcgggcgcgg agatcttgaa atcgcagttg    34320

ggacccgcgt tctgcgcgcg agagttgcgg tacacggggt tgcagcactg gaacaccatc    34380

agggccgggt gcttcacgct cgccagcacc gccgcgtcgg tgatgctctc cacgtcgagg    34440

tcctcggcgt tggccatccc gaagggggtc atcttgcagg tctgccttcc catggtgggc    34500

acgcacccgg gcttgtggtt gcaatcgcag tgcaggggga tcagcatcat ctgggcctgg    34560

tcggcgttca tccccgggta catggccttc atgaaagcct ccaattgcct gaacgcctgc    34620

tgggccttgg ctccctcggt gaagaagacc ccgcaggact tgctagagaa ctggttggtg    34680

gcacagccgg catcgtgcac gcagcagcgc gcgtcgttgt tggccagctg caccacgctg    34740

cgcccccagc ggttctgggt gatcttggcc cggtcggggt tctccttcag cgcgcgctgc    34800

ccgttctcgc tcgccacatc catctcgatc atgtgctcct tctggatcat ggtggtcccg    34860

tgcaggcacc gcagtttgcc ctcggcctcg gtgcacccgt gcagccacag cgcgcacccg    34920

gtgcactccc agttcttgtg ggcgatctgg gaatgcgcgt gcacgaaccc ttgcaggaag    34980

cggcccatca tggtcgtcag ggtcttgttg ctagtgaagg tcaacgggat gccgcggtgc    35040

tcctcgttga tgtacaggtg gcagatgcgg cggtacacct cgccctgctc gggcatcagt    35100

tggaagttgg ctttcaggtc ggtctccacg cggtagcggt ccatcagcat agtcatgatt    35160

tccatgccct tctcccaggc cgagacgatg ggcaggctca tagggttctt caccatcatc    35220

ttagcactag cagccgcggc cagggggtcg ctctcatcca gggtctcaaa gctccgcttg    35280

ccgtccttct cggtgatccg caccgggggg tagctgaagc ccacggccgc cagctcctcc    35340

tcggcctgtc tttcgtcctc gctgtcctgg ctgacgtcct gcatgaccac atgcttggtc    35400

ttgcggggtt tcttcttggg cggcagtggc ggcggagatg cttgtggcga gggggagcgc    35460

gagttctcgc tcaccactac tatctcttcc tcttcttggt ccgaggccac gcggcggtag    35520

gtatgtctct tcgggggcag aggcggaggc gacgggctct cgccgccgcg acttggcgga    35580

tggctggcag agccccttcc gcgttcgggg gtgcgctccc ggcggcgctc tgactgactt    35640

cctccgcggc cggccattgt gttctcctag ggaggaacaa caagcatgga gactcagcca    35700

tcgccaacct cgccatctgc ccccaccgcc ggcgacgaga agcagcagca gcagaatgaa    35760

agcttaaccg ccccgccgcc cagccccgcc tccgacgcag ccgcggtccc agacatgcaa    35820

gagatggagg aatccatcga gattgacctg ggctatgtga cgcccgcgga gcatgaggag    35880

gagctggcag tgcgctttca atcgtcaagc caggaagata aagaacagcc agagcaggaa    35940

gcagagaacg agcagagtca ggctgggctc gagcatggcg actacctcca cctgagcggg    36000

gaggaggacg cgctcatcaa gcatctggcc cggcaggcca ccatcgtcaa ggacgcgctg    36060

ctcgaccgca ccgaggtgcc cctcagcgtg gaggagctca gccgcgccta cgagctcaac    36120

ctcttctcgc cgcgcgtgcc ccccaagcgc cagcccaacg gcacctgcga gcccaacccc    36180

cgcctcaact tctacccggt cttcgcggtg cccgaggccc tggccaccta ccacatcttt    36240

ttcaagaacc aaaagatccc cgtctcctgc cgcgccaacc gcacccgcgc cgacgccctc    36300

ttcaacctgg gtcccggcgc ccgcctacct gatatcgcct ccttggaaga ggttcccaag    36360

atcttcgagg gtctgggcag cgacgagact cgggccgcga acgctctgca aggagaagga    36420

ggaggagagc atgagcacca cagcgccctg gtcgagttgg aaggcgacaa cgcgcggctg    36480

gcggtgctca aacgcacggt cgagctgacc catttcgcct acccggctct gaacctgccc    36540

ccgaaagtca tgagcgcggt catggaccag gtgctcatca agcgcgcgtc gcccatctcc    36600

gaggacgagg gcatgcaaga ctccgaggag ggcaagcccg tggtcagcga cgagcagctg    36660

gcccggtggc tgggtcctaa tgctacccct caaagtttgg aagagcggcg caagctcatg    36720

atggccgtgg tcctggtgac cgtggagctg gagtgcctgc gccgcttctt cgccgacgcg    36780

gagaccctgc gcaaggtcga ggagaacctg cactacctct tcaggcacgg gttcgtgcgc    36840

caggcctgca agatctccaa cgtggagctg accaacctgg tctcctacat gggcatcttg    36900

cacgagaacc gcctggggca gaacgtgctg cacaccaccc tgcgcgggga ggcccgccgc    36960

gactacatcc gcgactgcgt ctacctctac ctctgccaca cctggcagac gggcatgggc    37020

gtgtggcagc agtgtctgga ggagcagaac ctgaaagagc tctgcaagct cctgcaaaag    37080

aacctcaagg gtctgtggac cgggttcgac gagcggacca ccgcctcgga cctggccgac    37140

ctcatcttcc ccgagcgcct caggctgacg ctgcgcaacg gcctgcccga ctttatgagc    37200

caaagcatgt tgcaaaactt tcgctctttc atcctcgaac gctccggaat cctgcccgcc    37260

acctgctccg cgctgccctc ggacttcgtg ccgctgacct tccgcgagtg ccccccgccg    37320

ctgtggagcc actgctacct gctgcgcctg gccaactacc tggcctacca ctcggacgtg    37380

atcgaggacg tcagcggcga gggcctgctc gagtgccact gccgctgcaa cctctgcacg    37440

ccgcaccgct ccctggcctg caacccccag ctgctgagcg agacccagat catcggcacc    37500

ttcgagttgc aagggcccag cgagggcgag ggagccaagg ggggtctgaa actcaccccg    37560

gggctgtgga cctcggccta cttgcgcaag ttcgtgcccg aggattacca tcccttcgag    37620

atcaggttct acgaggacca atcccagccg cccaaggccg agctgtcggc ctgcgtcatc    37680

acccaggggg cgatcctggc ccaattgcaa gccatccaga aatcccgcca agaattcttg    37740

ctgaaaaagg gccgcggggt ctacctcgac ccccagaccg gtgaggagct caaccccggc    37800

ttcccccagg atgccccgag gaaacaagaa gctgaaagtg gagctgccgc ccgtggagga    37860

tttggaggaa gactgggaga acagcagtca ggcagaggag atggaggaag actgggacag    37920

cactcaggca gaggaggaca gcctgcaaga cagtctggag gaagacgagg aggaggcaga    37980

ggaggaggtg gaagaagcag ccgccgccag accgtcgtcc tcggcggggg agaaagcaag    38040

cagcacggat accatctccg ctccgggtcg gggtcccgct cggccccaca gtagatggga    38100

cgagaccggg cgattcccga accccaccac ccagaccggt aagaaggagc ggcagggata    38160

caagtcctgg cgggggcaca aaaacgccat cgtctcctgc ttgcaggcct gcgggggcaa    38220

catctccttc acccggcgct acctgctctt ccaccgcggg gtgaacttcc cccgcaacat    38280

cttgcattac taccgtcacc tccacagccc ctactacttc caagaagagg cagcagcagc    38340

agaaaaagac cagaaaacca gctagaaaat ccacagcggc ggcagcggca ggtggactga    38400

ggatcgcggc gaacgagccg gcgcagaccc gggagctgag gaaccggatc tttcccaccc    38460

tctatgccat cttccagcag agtcgggggc aggagcagga actgaaagtc aagaaccgtt    38520

ctctgcgctc gctcacccgc agttgtctgt atcacaagag cgaagaccaa cttcagcgca    38580

ctctcgagga cgccgaggct ctcttcaaca agtactgcgc gctcactctt aaagagtagc    38640

ccgcgcccgc ccagtcgcag aaaaaggcgg gaattacgtc acctgtgccc ttcgccctag    38700

ccgcctccac ccagcaccgc catgagcaaa gagattccca cgccttacat gtggagctac    38760

cagccccaga tgggcctggc cgccggcgcc gcccaggact actccacccg catgaattgg    38820

ctcagcgccg ggcccgcgat gatctcacgg gtgaatgaca tccgcgccca ccgaaaccag    38880

atactcctag aacagtcagc gctcaccgcc acgccccgca atcacctcaa tccgcgtaat    38940

tggcccgccg ccctggtgta ccaggaaatt ccccagccca cgaccgtact acttccgcga    39000

gacgcccagg ccgaagtcca gctgactaac tcaggtgtcc agctggcggg cggcgccacc    39060

ctgtgtcgtc accgccccgc tcagggtata aagcggctgg tgatccgggg cagaggcaca    39120

cagctcaacg acgaggtggt gagctcttcg ctgggtctgc gacctgacgg agtcttccaa    39180

ctcgccggat cggggagatc ttccttcacg cctcgtcagg cggtcctgac tttggagagt    39240

tcgtcctcgc agccccgctc gggcggcatc ggcactctcc agttcgtgga ggagttcact    39300

ccctcggtct acttcaaccc cttctccggc tcccccggcc actacccgga cgagttcatc    39360

ccgaactttg acgccatcag cgagtcggtg gacggctacg attgattaat taatcaacta    39420

accccttacc cctttaccct ccagtaaaaa taaagattaa aaatgattga attgatcaat    39480

aaagaatcac ttacttgaaa tctgaaacca ggtctctgtc catgttttct gtcagcagca    39540

cttcactccc ctcttcccaa ctctggtact gcaggccccg gcgggctgca aacttcctcc    39600

acactctgaa ggggatgtca aattcctcct gtccctcaat cttcattttt atcttctatc    39660

agatgtccaa aaagcgcgcg cgggtggatg atggcttcga ccccgtgtac ccctacgatg    39720

cagacaacgc accgactgtg cccttcatca accctccctt cgtctcttca gatggattcc    39780

aagaaaagcc cctgggggtg ttgtccctgc gactggccga ccccgtcacc accaagaatg    39840

gggctgtcac cctcaagctg ggggaggggg tggacctcga cgactcggga aaactcatct    39900

ccaaaaatgc caccaaggcc actgcccctc tcagtatttc caacggcacc atttccctta    39960

acatggctgc ccctttttac aacaacaatg gaacgttaag tctcaatgtt tctacaccat    40020

tagcagtatt tcccactttt aacactttag gtatcagtct tggaaacggt cttcaaactt    40080

ctaataagtt gctgactgta cagttaactc atcctcttac attcagctca aatagcatca    40140

cagtaaaaac agacaaagga ctctatatta attctagtgg aaacagaggg cttgaggcta    40200

acataagcct aaaaagagga ctgatttttg atggtaatgc tattgcaaca taccttggaa    40260

gtggtttaga ctatggatcc tatgatagcg atgggaaaac aagacccatc atcaccaaaa    40320

ttggagcagg tttgaatttt gatgctaata atgccatggc tgtgaagcta ggcacaggtt    40380

taagttttga ctctgccggt gccttaacag ctggaaacaa agaggatgac aagctaacac    40440

tttggactac acctgaccca agccctaatt gtcaattact ttcagacaga gatgccaaat    40500

ttaccctatg tcttacaaaa tgcggtagtc aaatactagg cactgttgca gtagctgctg    40560

ttactgtagg ttcagcacta aatccaatta atgacacagt aaaaagcgcc atagtattcc    40620

ttagatttga ctctgacggt gtgctcatgt caaactcatc aatggtaggt gattactgga    40680

actttaggga aggacagacc acccaaagtg tggcctatac aaatgctgtg ggattcatgc    40740

ccaatctagg tgcatatcct aaaacccaaa gcaaaacacc aaaaaatagt atagtaagtc    40800

aggtatattt aaatggagaa actactatgc caatgacact gacaataact ttcaatggca    40860

ctgatgaaaa agacacaaca cctgtgagca cttactccat gacttttaca tggcagtgga    40920

ctggagacta taaggacaag aatattacct ttgctaccaa ctcctttact ttctcctaca    40980

tggcccaaga ataaaccctg catgccaacc ccattgttcc caccactatg gaaaactctg    41040

aagcagaaaa aaataaagtt caagtgtttt attgattcaa cagttttctc acagaaccct    41100

agtattcaac ctgccacctc cctcccaaca cacagagtac acagtccttt ctccccggct    41160

ggccttaaaa agcatcatat catgggtaac agacatattc ttaggtgtta tattccacac    41220

ggtttcctgt cgagccaaac gctcatcagt gatattaata aactccccgg gcagctcact    41280

taagttcatg tcgctgtcca gctgctgagc cacaggctgc tgtccaactt gcggttgctt    41340

aacgggcggc gaaggagaag tccacgccta catgggggta gagtcataat cgtgcatcag    41400

gatagggcgg tggtgctgca gcagcgcgcg aataaactgc tgccgccgcc gctccgtcct    41460

gcaggaatac aacatggcag tggtctcctc agcgatgatt cgcaccgccc gcagcataag    41520

gcgccttgtc ctccgggcac agcagcgcac cctgatctca cttaaatcag cacagtaact    41580

gcagcacagc accacaatat tgttcaaaat cccacagtgc aaggcgctgt atccaaagct    41640

catggcgggg accacagaac ccacgtggcc atcataccac aagcgcaggt agattaagtg    41700

gcgacccctc ataaacacgc tggacataaa cattacctct tttggcatgt tgtaattcac    41760

cacctcccgg taccatataa acctctgatt aaacatggcg ccatccacca ccatcctaaa    41820

ccagctggcc aaaacctgcc cgccggctat acactgcagg gaaccgggac tggaacaatg    41880

acagtggaga gcccaggact cgtaaccatg gatcatcatg ctcgtcatga tatcaatgtt    41940

ggcacaacac aggcacacgt gcatacactt cctcaggatt acaagctcct cccgcgttag    42000

aaccatatcc cagggaacaa cccattcctg aatcagcgta aatcccacac tgcagggaag    42060

acctcgcacg taactcacgt tgtgcattgt caaagtgtta cattcgggca gcagcggatg    42120

atcctccagt atggtagcgc gggtttctgt ctcaaaagga ggtagacgat ccctactgta    42180

cggagtgcgc cgagacaacc gagatcgtgt tggtcgtagt gtcatgccaa atggaacgcc    42240

ggacgtagtc atatttcctg aagcaaaacc aggtgcgggc gtgacaaaca gatctgcgtc    42300

tccggtctcg ccgcttagat cgctctgtgt agtagttgta gtatatccac tctctcaaag    42360

catccaggcg ccccctggct tcgggttcta tgtaaactcc ttcatgcgcc gctgccctga    42420

taacatccac caccgcagaa taagccacac ccagccaacc tacacattcg ttctgcgagt    42480

cacacacggg aggagcggga agagctggaa gaaccatgat taactttatt ccaaacggtc    42540

tcggagcact tcaaaatgca ggtcccggag gtggcacctc tcgcccccac tgtgttggtg    42600

gaaaataaca gccaggtcaa aggtgacacg gttctcgaga tgttccacgg tggcttccag    42660

caaagcctcc acgcgcacat ccagaaacaa gaggacagcg aaagcgggag cgttttctaa    42720

ttcctcaatc atcatattac actcctgcac catccccaga taattttcat ttttccagcc    42780

ttgaatgatt cgtattagtt cctgaggtaa atccaagcca gccatgataa aaagctcgcg    42840

cagagcgccc tccaccggca ttcttaagca caccctcata attccaagag attctgctcc    42900

tggttcacct gcagcagatt aacaatggga atatcaaaat ctctgccgcg atccctaagc    42960

tcctccctca acaataactg tatgtaatct ttcatatcat ctccgaaatt tttagccata    43020

gggccgccag gaataagagc agggcaagcc acattacaga taaagcgaag tcctccccag    43080

tgagcattgc caaatgtaag attgaaataa gcatgctggc tagaccctgt gatatcttcc    43140

agataactgg acagaaaatc aggcaagcaa tttttaagaa aatcaacaaa agaaaagtcg    43200

tccaggtgca ggtttagagc ctcaggaaca acgatggaat aagtgcaagg agtgcgttcc    43260

agcatggtta gtgttttttt ggtgatctgt agaacaaaaa ataaacatgc aatattaaac    43320

catgctagcc tggcgaacag gtgggtaaat cactctttcc agcaccaggc aggctacggg    43380

gtctccggcg cgaccctcgt agaagctgtc gccatgattg aaaagcatca ccgagagacc    43440

ttcccggtgg ccggcatgga tgattcgaga agaagcatac actccgggaa cattggcatc    43500

cgtgagtgaa aaaaagcgac ctataaagcc tcggggcact acaatgctca atctcaattc    43560

cagcaaagcc accccatgcg gatggagcac aaaattggca ggtgcgtaaa aaatgtaatt    43620

actcccctcc tgcacaggca gcaaagcccc cgctccctcc agaaacacat acaaagcctc    43680

agcgtccata gcttaccgag cacggcaggc gcaagagtca gagaaaaggc tgagctctaa    43740

cctgactgcc cgctcctgtg ctcaatatat agccctaacc tacactgacg taaaggccaa    43800

agtctaaaaa tacccgccaa aatgacacac acgcccagca cacgcccaga aaccggtgac    43860

acactcaaaa aaatacgtgc gcttcctcaa acgcccaaac cggcgtcatt tccgggttcc    43920

cacgctacgt caccgctcag cgactttcaa attccgtcga ccgttaaaaa cgtcactcgc    43980

cccgccccta acggtcgccc ttctctcggc caatcacctt cctcccttcc caaattcaaa    44040

cgcctcattt gcatattaac gcgcacaaaa agtttgaggt atatatttga atgatggttt    44100

aaac                                                                 44104


<210>  16
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  501Y.V2 - Brazil - Jenner C - wildtype

<400>  16

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  17
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  501Y.V2 - Brazil - Jenner C - S2P

<400>  17

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  18
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  501Y.V2 - Brazil - Jenner C - hexapro

<400>  18

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  19
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  501Y.V3 - South Africa - Jenner D - wildtype

<400>  19

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  20
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  501Y.V3 - South Africa - Jenner D - S2P

<400>  20

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  21
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  501Y.V3 - South Africa - Jenner D - hexapro

<400>  21

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  22
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  501Y.V3 - South Africa - Jenner E.2 - S2P

<400>  22

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  23
<211>  3906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence coding for tPA-SARS CoV-2 spike protein E 
       variant AZD2816 (SEQ ID NO: 3).

tPA coding sequence = nt 1-96.

<400>  23
atggacgcca tgaagcgagg cctgtgctgt gttctgcttc tgtgtggcgc cgtgtttgtg       60

tccgccagcc aagagatcca cgccagattt cggagattcg tgttcctggt gctgctgcca      120

ctggtgtcta gccagtgtgt gaactttacc accaggacac agctgcctcc agcctacacc      180

aacagcttca ccagaggcgt gtactaccca gacaaggtgt tcagatccag cgtgctgcac      240

tctacccagg acctgttcct gcctttcttc agcaacgtga cctggttcca cgccatccac      300

gtgtccggca ccaatggcac caagagattc gccaacccag tgctgccctt caacgacgga      360

gtgtactttg ccagcaccga gaagtccaac atcatcagag gctggatctt cggcaccaca      420

ctggacagca agacccagag cctgctgatc gtgaacaacg ccaccaacgt ggtcatcaaa      480

gtgtgcgagt tccagttctg caacgaccca ttcctgggcg tctactacca caagaacaac      540

aagagctgga tggaaagcga gttccgggtg tacagcagcg ccaacaactg caccttcgag      600

tacgtgtccc agcctttcct gatggacctg gaaggcaagc agggcaactt caagaacctg      660

cgcgagttcg tgttcaagaa catcgacggc tacttcaaga tctacagcaa gcacacacct      720

atcaacctcg tgcggggcct gcctcagggc ttctctgctc tggaaccact ggtggatctg      780

cccatcggca tcaacatcac ccggtttcag acactgcaca gaagctacct gacacctggc      840

gatagcagct ctggatggac agctggcgcc gctgcctact atgtgggata cctgcagcct      900

cggaccttcc tgctgaagta caacgagaac ggcaccatca ccgacgccgt ggattgtgct      960

ctggatcctc tgagcgagac aaagtgcacc ctgaagtcct tcaccgtgga aaagggcatc     1020

taccagacca gcaacttccg ggtgcagccc accgaatcca tcgtgcggtt cccgaatatc     1080

accaatctgt gcccattcgg cgaggtgttc aatgccacca gattcgcctc tgtgtacgcc     1140

tggaaccgga agcggatcag caattgcgtg gccgactact ccgtgctgta caactccgcc     1200

agcttcagca ccttcaagtg ctacggcgtg tcacctacca agctgaacga cctgtgcttc     1260

acaaacgtgt acgccgacag cttcgtgatc cgtggagatg aagtgcggca gattgcacct     1320

ggacagacag gcaatatcgc cgactacaac tacaagctgc ccgacgactt caccggctgt     1380

gtgattgcct ggaacagcaa caacctggat agcaaagtcg gcggcaacta caattacctg     1440

taccggctgt tccggaagtc caatctgaag cccttcgagc gggacatctc caccgagatc     1500

tatcaggccg gcagcacacc ttgtaacggc gtgaaaggct tcaactgcta cttcccactg     1560

cagtcctacg gctttcagcc cacatatggc gtgggctacc agccttacag agtggtggtg     1620

ctgagcttcg agctgctgca tgctcctgcc acagtgtgcg gccctaagaa aagcaccaat     1680

ctcgtgaaga acaaatgcgt gaacttcaac ttcaacggcc tgaccggcac cggcgtgctg     1740

acagagagca acaagaagtt cctgccattc cagcagttcg gccgggatat cgccgatacc     1800

acagatgccg tcagagatcc tcagacactg gaaatcctgg acatcacacc ttgcagcttc     1860

ggcggagtgt ctgtgatcac gcctggcacc aacaccagca atcaggtggc agtgctgtac     1920

cagggtgtga actgtaccga agtgcccgtg gccattcacg ccgatcagct gacacctaca     1980

tggcgggtgt actccaccgg cagcaatgtg tttcagacca gagccggctg tctgatcgga     2040

gccgagcacg tgaacaatag ctacgagtgc gacatcccta tcggcgctgg catctgcgcc     2100

tcttaccaga cacagacaaa cagccctaga cgggccagat ctgtggccag ccagagcatc     2160

attgcctaca caatgtctct gggcgtggag aacagcgtgg cctactccaa caactctatc     2220

gctatcccga ccaacttcac catcagcgtg accacagaga tcctgcctgt gtccatgacc     2280

aagaccagcg tggactgcac catgtacatc tgcggcgatt ccaccgagtg ctccaacctg     2340

ctgctgcagt acggcagctt ctgcacccag ctgaatagag ccctgacagg gatcgccgtg     2400

gaacaggaca agaacaccca agaggtgttc gcccaagtga agcagatcta caagacgcct     2460

cctatcaagg acttcggcgg cttcaatttc agccagattc tgcccgatcc tagcaagccc     2520

agcaagcgga gcttcatcga ggacctgctg ttcaacaaag tgacactggc cgacgccggc     2580

ttcatcaagc agtatggcga ttgtctgggc gacattgccg ccagggatct gatttgcgcc     2640

cagaagttta acggactgac agtgctgcct cctctgctga ccgatgagat gatcgcccag     2700

tacacatctg ccctgctggc cggcacaatc acaagcggct ggacatttgg agctggcgct     2760

gccctgcaga tcccatttgc tatgcagatg gcctaccggt tcaacggcat cggagtgacc     2820

cagaatgtgc tgtacgagaa ccagaagctg atcgccaacc agttcaacag cgccatcggc     2880

aagatccagg acagcctgag cagcacagca agcgccctgg gaaagctgca ggacgtggtc     2940

aaccagaatg cccaggcact gaacaccctg gtcaagcagc tgtctagcaa cttcggcgcc     3000

atcagctctg tgctgaacga tatcctgagc agactggaca aggtggaagc cgaggtgcag     3060

atcgacagac tgatcaccgg aaggctgcag tccctgcaga cctacgttac ccagcagctg     3120

atcagagccg ccgagattag agcctctgcc aatctggccg ccaccaagat gtctgagtgt     3180

gtgctgggcc agagcaagag agtggacttt tgcggcaagg gctaccacct gatgagcttc     3240

cctcagtctg cgcctcacgg cgtggtgttt ctgcacgtga catacgtgcc cgctcaagag     3300

aagaatttca ccaccgctcc agccatctgc cacgacggca aagcccactt tcctagagaa     3360

ggcgtgttcg tgtccaacgg cacccattgg ttcgtgaccc agcggaactt ctacgagcct     3420

cagatcatca ccaccgacaa caccttcgtg tctggcaact gcgacgtcgt gatcggcatt     3480

gtgaacaata ccgtgtacga ccctctgcag cccgagctgg acagcttcaa agaggaactg     3540

gataagtact ttaagaacca cacaagccct gacgtggacc tgggcgatat cagcggaatc     3600

aatgccagcg tcgtgaacat ccagaaagag atcgaccggc tgaacgaggt ggccaagaat     3660

ctgaacgaga gcctgatcga cctgcaagaa ctgggcaagt acgagcagta catcaagtgg     3720

ccctggtaca tctggctggg ctttatcgcc ggactgattg ccatcgtgat ggtcacaatc     3780

atgctgtgtt gcatgaccag ctgctgtagc tgcctgaagg gctgttgtag ctgtggctcc     3840

tgctgcaagt tcgacgagga cgattctgag cccgtgctga agggcgtgaa actgcactac     3900

acctga                                                                3906


<210>  24
<211>  3906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence coding for tPA-SARS CoV-2 spike protein E6 
       variant in AZD3990

tPA coding sequence = nt 1-96.

<400>  24
atggacgcca tgaagcgagg cctgtgctgt gttctgcttc tgtgtggcgc cgtgtttgtg       60

tccgccagcc aagagatcca cgccagattt cggagattcg tgttcctggt gctgctgcca      120

ctggtgtcta gccagtgtgt gaactttacc accaggacac agctgcctcc agcctacacc      180

aacagcttca ccagaggcgt gtactaccca gacaaggtgt tcagatccag cgtgctgcac      240

tctacccagg acctgttcct gcctttcttc agcaacgtga cctggttcca cgccatccac      300

gtgtccggca ccaatggcac caagagattc gctaacccag tgctgccctt caacgacgga      360

gtgtactttg ccagcaccga gaagtccaac atcatcagag gctggatctt cggcaccaca      420

ctggacagca agacccagag cctgctgatc gtgaacaacg ccaccaacgt ggtcatcaaa      480

gtgtgcgagt tccagttctg caacgaccca ttcctgggcg tctactacca caagaacaac      540

aagagctgga tggaaagcga gttccgggtg tacagcagcg ccaacaactg caccttcgag      600

tacgtgtccc agcctttcct gatggacctg gaaggcaagc agggcaactt caagaacctg      660

cgcgagttcg tgttcaagaa catcgacggc tacttcaaga tctacagcaa gcacacacct      720

atcaacctcg tgcggggcct gcctcagggc ttctctgctc tggaaccact ggtggatctg      780

cccatcggca tcaacatcac ccggtttcag acactgcaca gaagctacct gacacctggc      840

gatagcagct ctggatggac agctggcgcc gctgcctact atgtgggata cctgcagcct      900

cggaccttcc tgctgaagta caacgagaac ggcaccatca ccgacgccgt ggattgtgct      960

ctggatcctc tgagcgagac aaagtgcacc ctgaagtcct tcaccgtgga aaagggcatc     1020

taccagacca gcaacttccg ggtgcagccc accgaatcca tcgtgcggtt cccgaatatc     1080

accaatctgt gcccattcgg cgaggtgttc aatgccacca gattcgcctc tgtgtacgcc     1140

tggaaccgga agcggatcag caattgcgtg gccgactact ccgtgctgta caactccgcc     1200

agcttcagca ccttcaagtg ctacggcgtg tcacctacca agctgaacga cctgtgcttc     1260

acaaacgtgt acgccgacag cttcgtgatc cgtggagatg aagtgcggca gattgcacct     1320

ggacagacag gcaatatcgc cgactacaac tacaagctgc ccgacgactt caccggctgt     1380

gtgattgcct ggaacagcaa caacctggat agcaaagtcg gcggcaacta caattacctg     1440

taccggctgt tccggaagtc caatctgaag cccttcgagc gggacatctc caccgagatc     1500

tatcaggccg gcagcacacc ttgtaacggc gtgaaaggct tcaactgcta cttcccactg     1560

cagtcctacg gctttcagcc cacatatggc gtgggctacc agccttacag agtggtggtg     1620

ctgagcttcg agctgctgca tgctcctgcc acagtgtgcg gccctaagaa aagcaccaat     1680

ctcgtgaaga acaaatgcgt gaacttcaac ttcaacggcc tgaccggcac cggcgtgctg     1740

acagagagca acaagaagtt cctgccattc cagcagttcg gccgggatat cgccgatacc     1800

acagatgccg tcagagatcc tcagacactg gaaatcctgg acatcacacc ttgcagcttc     1860

ggcggagtgt ctgtgatcac gcctggcacc aacaccagca atcaggtggc agtgctgtac     1920

cagggtgtga actgtaccga agtgcccgtg gccattcacg ccgatcagct gacacctaca     1980

tggcgggtgt actccaccgg cagcaatgtg tttcagacca gagccggctg tctgatcgga     2040

gccgagcacg tgaacaatag ctacgagtgc gacatcccta tcggcgctgg catctgcgcc     2100

tcttaccaga cacagacaaa cagccctaga cgggccagat ctgtggccag ccagagcatc     2160

attgcctaca caatgtctct gggcgtggag aacagcgtgg cctactccaa caactctatc     2220

gctatcccga ccaacttcac catcagcgtg accacagaga tcctgcctgt gtccatgacc     2280

aagaccagcg tggactgcac catgtacatc tgcggcgatt ccaccgagtg ctccaacctg     2340

ctgctgcagt acggcagctt ctgcacccag ctgaatagag ccctgacagg gatcgccgtg     2400

gaacaggaca agaacaccca agaggtgttc gcccaagtga agcagatcta caagacgcct     2460

cctatcaagg acttcggcgg cttcaatttc agccagattc tgcccgatcc tagcaagccc     2520

agcaagcgga gccctatcga ggacctgctg ttcaacaaag tgacactggc cgacgccggc     2580

ttcatcaagc agtatggcga ttgtctgggc gacattgccg ccagggatct gatttgcgcc     2640

cagaagttta acggactgac agtgctgcct cctctgctga ccgatgagat gatcgcccag     2700

tacacatctg ccctgctggc cggcacaatc acaagcggct ggacatttgg agctggccct     2760

gccctgcaga tcccatttcc tatgcagatg gcctaccggt tcaacggcat cggagtgacc     2820

cagaatgtgc tgtacgagaa ccagaagctg atcgccaacc agttcaacag cgccatcggc     2880

aagatccagg acagcctgag cagcacacct agcgccctgg gaaagctgca ggacgtggtc     2940

aaccagaatg cccaggcact gaacaccctg gtcaagcagc tgtctagcaa cttcggcgcc     3000

atcagctctg tgctgaacga tatcctgagc agactggacc ctcctgaagc cgaggtgcag     3060

atcgacagac tgatcaccgg aaggctgcag tccctgcaga cctacgttac ccagcagctg     3120

atcagagccg ccgagattag agcctctgcc aatctggccg ccaccaagat gtctgagtgt     3180

gtgctgggcc agagcaagag agtggacttt tgcggcaagg gctaccacct gatgagcttc     3240

cctcagtctg cgcctcacgg cgtggtgttt ctgcacgtga catacgtgcc cgctcaagag     3300

aagaatttca ccaccgctcc agccatctgc cacgacggca aagcccactt tcctagagaa     3360

ggcgtgttcg tgtccaacgg cacccattgg ttcgtgaccc agcggaactt ctacgagcct     3420

cagatcatca ccaccgacaa caccttcgtg tctggcaact gcgacgtcgt gatcggcatt     3480

gtgaacaata ccgtgtacga ccctctgcag cccgagctgg acagcttcaa agaggaactg     3540

gataagtact ttaagaacca cacaagccct gacgtggacc tgggcgatat cagcggaatc     3600

aatgccagcg tcgtgaacat ccagaaagag atcgaccggc tgaacgaggt ggccaagaat     3660

ctgaacgaga gcctgatcga cctgcaagaa ctgggcaagt acgagcagta catcaagtgg     3720

ccctggtaca tctggctggg ctttatcgcc ggactgattg ccatcgtgat ggtcacaatc     3780

atgctgtgtt gcatgaccag ctgctgtagc tgcctgaagg gctgttgtag ctgtggctcc     3840

tgctgcaagt tcgacgagga cgattctgag cccgtgctga agggcgtgaa actgcactac     3900

acctga                                                                3906


<210>  25
<211>  35530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AZD3990: Full Genome sequence AZD3990 (E6)

<400>  25
aaacccatca tcaataatat acctcaaact ttttgtgcgc gttaatatgc aaatgaggcg       60

tttgaatttg ggaagggagg aaggtgattg gccgagagaa gggcgaccgt taggggcggg      120

gcgagtgacg ttttgatgac gtgaccgcga ggaggagcca gtttgcaagt tctcgtggga      180

aaagtgacgt caaacgaggt gtggtttgaa cacggaaata ctcaattttc ccgcgctctc      240

tgacaggaaa tgaggtgttt ctaggcggat gcaagtgaaa acgggccatt ttcgcgcgaa      300

aactgaatga ggaagtgaaa atctgagtaa tttcgcgttt atgacaggga ggagtatttg      360

ccgagggccg agtagacttt gaccgattac gtgggggttt cgattaccgt gtttttcacc      420

taaatttccg cgtacggtgt caaagtccgg tgtttttacg taggtgtcag ctgatcgcca      480

gggtatttaa acctgcgctc tccagtcaag aggccactct tgagtgccag cgagaagagt      540

tttctcctcc gcgcgcgagt cagatctaca ctttgaaagg cgatcgctag cgacatcgat      600

cacaagtttg tacaaaaaag caggctccac catgggaacc cgcgttttga gatttctgtc      660

gccgactaaa ttcatgtcgc gcgatagtgg tgtttatcgc cgatagagat ggcgatattg      720

gaaaaatcga tatttgaaaa tatggcatat tgaaaatgtc gccgatgtga gtttctgtgt      780

aactgatatc gccatttttc caaaagtgat ttttgggcat acgcgatatc tggcgatagc      840

gcttatatcg tttacggggg atggcgatag acgactttgg tgacttgggc gattctgtgt      900

gtcgcaaata tcgcagtttc gatataggtg acagacgata tgaggctata tcgccgatag      960

aggcgacatc aagctggcac atggccaatg catatcgatc tatacattga atcaatattg     1020

gccattagcc atattattca ttggttatat agcataaatc aatattggct attggccatt     1080

gcatacgttg tatccatatc ataatatgta catttatatt ggctcatgtc caacattacc     1140

gccatgttga cattgattat tgactagtta ttaatagtaa tcaattacgg ggtcattagt     1200

tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg     1260

accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc     1320

aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc     1380

agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg     1440

gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat     1500

ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca tcaatgggcg     1560

tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag     1620

tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact ccgccccatt     1680

gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctctccctat     1740

cagtgataga gatctcccta tcagtgatag agatcgtcga cgagctcgtt tagtgaaccg     1800

tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgggaccg     1860

atccagcctc cgcggccggg aacggtgcat tggaacgcgg attccccgtg ccaagagtga     1920

cgtaagtacc gcctatagag tctataggcc cacccccttg gcttcttatg catgctatac     1980

tgtttttggc ttggggtcta tacacccccg cttcctcatg ttataggtga tggtatagct     2040

tagcctatag gtgtgggtta ttgaccatta ttgaccactc ccctattggt gacgatactt     2100

tccattacta atccataaca tggctctttg ccacaactct ctttattggc tatatgccaa     2160

tacactgtcc ttcagagact gacacggact ctgtattttt acaggatggg gtctcattta     2220

ttatttacaa attcacatat acaacaccac cgtccccagt gcccgcagtt tttattaaac     2280

ataacgtggg atctccacgc gaatctcggg tacgtgttcc ggacatgggc tcttctccgg     2340

tagcggcgga gcttctacat ccgagccctg ctcccatgcc tccagcgact catggtcgct     2400

cggcagctcc ttgctcctaa cagtggaggc cagacttagg cacagcacga tgcccaccac     2460

caccagtgtg ccgcacaagg ccgtggcggt agggtatgtg tctgaaaatg agctcgggga     2520

gcgggcttgc accgctgacg catttggaag acttaaggca gcggcagaag aagatgcagg     2580

cagctgagtt gttgtgttct gataagagtc agaggtaact cccgttgcgg tgctgttaac     2640

ggtggagggc agtgtagtct gagcagtact cgttgctgcc gcgcgcgcca ccagacataa     2700

tagctgacag actaacagac tgttcctttc catgggtctt ttctgcagtc accgtccttg     2760

acacgaagct tggtacctta atggacgcca tgaagcgagg cctgtgctgt gttctgcttc     2820

tgtgtggcgc cgtgtttgtg tccgccagcc aagagatcca cgccagattt cggagattcg     2880

tgttcctggt gctgctgcca ctggtgtcta gccagtgtgt gaactttacc accaggacac     2940

agctgcctcc agcctacacc aacagcttca ccagaggcgt gtactaccca gacaaggtgt     3000

tcagatccag cgtgctgcac tctacccagg acctgttcct gcctttcttc agcaacgtga     3060

cctggttcca cgccatccac gtgtccggca ccaatggcac caagagattc gctaacccag     3120

tgctgccctt caacgacgga gtgtactttg ccagcaccga gaagtccaac atcatcagag     3180

gctggatctt cggcaccaca ctggacagca agacccagag cctgctgatc gtgaacaacg     3240

ccaccaacgt ggtcatcaaa gtgtgcgagt tccagttctg caacgaccca ttcctgggcg     3300

tctactacca caagaacaac aagagctgga tggaaagcga gttccgggtg tacagcagcg     3360

ccaacaactg caccttcgag tacgtgtccc agcctttcct gatggacctg gaaggcaagc     3420

agggcaactt caagaacctg cgcgagttcg tgttcaagaa catcgacggc tacttcaaga     3480

tctacagcaa gcacacacct atcaacctcg tgcggggcct gcctcagggc ttctctgctc     3540

tggaaccact ggtggatctg cccatcggca tcaacatcac ccggtttcag acactgcaca     3600

gaagctacct gacacctggc gatagcagct ctggatggac agctggcgcc gctgcctact     3660

atgtgggata cctgcagcct cggaccttcc tgctgaagta caacgagaac ggcaccatca     3720

ccgacgccgt ggattgtgct ctggatcctc tgagcgagac aaagtgcacc ctgaagtcct     3780

tcaccgtgga aaagggcatc taccagacca gcaacttccg ggtgcagccc accgaatcca     3840

tcgtgcggtt cccgaatatc accaatctgt gcccattcgg cgaggtgttc aatgccacca     3900

gattcgcctc tgtgtacgcc tggaaccgga agcggatcag caattgcgtg gccgactact     3960

ccgtgctgta caactccgcc agcttcagca ccttcaagtg ctacggcgtg tcacctacca     4020

agctgaacga cctgtgcttc acaaacgtgt acgccgacag cttcgtgatc cgtggagatg     4080

aagtgcggca gattgcacct ggacagacag gcaatatcgc cgactacaac tacaagctgc     4140

ccgacgactt caccggctgt gtgattgcct ggaacagcaa caacctggat agcaaagtcg     4200

gcggcaacta caattacctg taccggctgt tccggaagtc caatctgaag cccttcgagc     4260

gggacatctc caccgagatc tatcaggccg gcagcacacc ttgtaacggc gtgaaaggct     4320

tcaactgcta cttcccactg cagtcctacg gctttcagcc cacatatggc gtgggctacc     4380

agccttacag agtggtggtg ctgagcttcg agctgctgca tgctcctgcc acagtgtgcg     4440

gccctaagaa aagcaccaat ctcgtgaaga acaaatgcgt gaacttcaac ttcaacggcc     4500

tgaccggcac cggcgtgctg acagagagca acaagaagtt cctgccattc cagcagttcg     4560

gccgggatat cgccgatacc acagatgccg tcagagatcc tcagacactg gaaatcctgg     4620

acatcacacc ttgcagcttc ggcggagtgt ctgtgatcac gcctggcacc aacaccagca     4680

atcaggtggc agtgctgtac cagggtgtga actgtaccga agtgcccgtg gccattcacg     4740

ccgatcagct gacacctaca tggcgggtgt actccaccgg cagcaatgtg tttcagacca     4800

gagccggctg tctgatcgga gccgagcacg tgaacaatag ctacgagtgc gacatcccta     4860

tcggcgctgg catctgcgcc tcttaccaga cacagacaaa cagccctaga cgggccagat     4920

ctgtggccag ccagagcatc attgcctaca caatgtctct gggcgtggag aacagcgtgg     4980

cctactccaa caactctatc gctatcccga ccaacttcac catcagcgtg accacagaga     5040

tcctgcctgt gtccatgacc aagaccagcg tggactgcac catgtacatc tgcggcgatt     5100

ccaccgagtg ctccaacctg ctgctgcagt acggcagctt ctgcacccag ctgaatagag     5160

ccctgacagg gatcgccgtg gaacaggaca agaacaccca agaggtgttc gcccaagtga     5220

agcagatcta caagacgcct cctatcaagg acttcggcgg cttcaatttc agccagattc     5280

tgcccgatcc tagcaagccc agcaagcgga gccctatcga ggacctgctg ttcaacaaag     5340

tgacactggc cgacgccggc ttcatcaagc agtatggcga ttgtctgggc gacattgccg     5400

ccagggatct gatttgcgcc cagaagttta acggactgac agtgctgcct cctctgctga     5460

ccgatgagat gatcgcccag tacacatctg ccctgctggc cggcacaatc acaagcggct     5520

ggacatttgg agctggccct gccctgcaga tcccatttcc tatgcagatg gcctaccggt     5580

tcaacggcat cggagtgacc cagaatgtgc tgtacgagaa ccagaagctg atcgccaacc     5640

agttcaacag cgccatcggc aagatccagg acagcctgag cagcacacct agcgccctgg     5700

gaaagctgca ggacgtggtc aaccagaatg cccaggcact gaacaccctg gtcaagcagc     5760

tgtctagcaa cttcggcgcc atcagctctg tgctgaacga tatcctgagc agactggacc     5820

ctcctgaagc cgaggtgcag atcgacagac tgatcaccgg aaggctgcag tccctgcaga     5880

cctacgttac ccagcagctg atcagagccg ccgagattag agcctctgcc aatctggccg     5940

ccaccaagat gtctgagtgt gtgctgggcc agagcaagag agtggacttt tgcggcaagg     6000

gctaccacct gatgagcttc cctcagtctg cgcctcacgg cgtggtgttt ctgcacgtga     6060

catacgtgcc cgctcaagag aagaatttca ccaccgctcc agccatctgc cacgacggca     6120

aagcccactt tcctagagaa ggcgtgttcg tgtccaacgg cacccattgg ttcgtgaccc     6180

agcggaactt ctacgagcct cagatcatca ccaccgacaa caccttcgtg tctggcaact     6240

gcgacgtcgt gatcggcatt gtgaacaata ccgtgtacga ccctctgcag cccgagctgg     6300

acagcttcaa agaggaactg gataagtact ttaagaacca cacaagccct gacgtggacc     6360

tgggcgatat cagcggaatc aatgccagcg tcgtgaacat ccagaaagag atcgaccggc     6420

tgaacgaggt ggccaagaat ctgaacgaga gcctgatcga cctgcaagaa ctgggcaagt     6480

acgagcagta catcaagtgg ccctggtaca tctggctggg ctttatcgcc ggactgattg     6540

ccatcgtgat ggtcacaatc atgctgtgtt gcatgaccag ctgctgtagc tgcctgaagg     6600

gctgttgtag ctgtggctcc tgctgcaagt tcgacgagga cgattctgag cccgtgctga     6660

agggcgtgaa actgcactac acctgataag cggccgctcg agcatgcatc tagagggccc     6720

tattctatag tgtcacctaa atgctagagc tcgctgatca gcctcgactg tgccttctag     6780

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     6840

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     6900

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     6960

caggcatgct ggggatgcgg tgggctctat ggcttctgag gcggaaagaa ccagctgggg     7020

ctcgaggggg gatcgatccg tcgagatatc tagacccagc tttcttgtac aaagtggtga     7080

tcgattcgac agatcgcgat cgcagtgagt agtgttctgg ggcgggggag gacctgcatg     7140

agggccagaa tgactgaaat ctgtgctttt ctgtgtgttg cagcatcatg agcggaagcg     7200

gctcctttga gggaggggta ttcagccctt atctgacggg gcgtctcccc tcctgggcgg     7260

gagtgcgtca gaatgtgatg ggatccacgg tggacggccg gcccgtgcag cccgcgaact     7320

cttcaaccct gacctatgca accctgagct cttcgtcggt ggacgcagct gccgccgcag     7380

ctgctgcatc cgccgccagc gccgtgcgcg gaatggccat gggcgccggc tactacggca     7440

ctctggtggc caactcgagt tccaccaata atcccgccag cctgaacgag gagaagctgc     7500

tgctgctgat ggcccagctt gaggccttga cccagcgcct gggcgagctg acccagcagg     7560

tggctcagct gcaggagcag acgcgggccg cggttgccac ggtgaaatcc aaataaaaaa     7620

tgaatcaata aataaacgga gacggttgtt gattttaaca cagagtctga atctttattt     7680

gatttttcgc gcgcggtagg ccctggacca ccggtctcga tcattgagca cccggtggat     7740

cttttccagg acccggtaga ggtgggcttg gatgttgagg tacatgggca tgagcccgtc     7800

ccgggggtgg aggtagctcc attgcagggc ctcgtgctcg ggggtggtgt tgtaaatcac     7860

ccagtcatag caggggcgca gggcgtggtg ttgcacaata tctttgagga ggagactgat     7920

ggccacgggc agccctttgg tgtaggtgtt tacaaatctg ttgagctggg agggatgcat     7980

gcggggggag atgaggtgca tcttggcctg gatcttgaga ttggcgatgt taccgcccag     8040

atcccgcctg gggttcatgt tgtgcaggac caccagcacg gtgtatccgg tgcacttggg     8100

gaatttatca tgcaacttgg aagggaaggc gtgaaagaat ttggcgacgc ccttgtgtcc     8160

gcccaggttt tccatgcact catccatgat gatggcaatg ggcccgtggg cggcggcctg     8220

ggcaaagacg tttcgggggt cggacacatc atagttgtgg tcctgggtga ggtcatcata     8280

ggccatttta atgaatttgg ggcggagggt gccggactgg gggacaaagg taccctcgat     8340

cccgggggcg tagttcccct cacagatctg catctcccag gctttgagct cagagggggg     8400

gatcatgtcc acctgcgggg cgataaagaa cacggtttcc ggggcggggg agatgagctg     8460

ggccgaaagc aagttccgga gcagctggga cttgccgcag ccggtggggc cgtaaatgac     8520

cccgatgacc ggctgcaggt ggtagttgag ggagagacag ctgccgtcct cccggaggag     8580

gggggccacc tcgttcatca tctcgcgcac gtgcatgttc tcgcgcacca gttccgccag     8640

gaggcgctct ccccccagag ataggagctc ctggagcgag gcgaagtttt tcagcggctt     8700

gagtccgtcg gccatgggca ttttggagag ggtctgttgc aagagttcca agcggtccca     8760

gagctcggtg atgtgctcta cggcatctcg atccagcaga cctcctcgtt tcgcgggttg     8820

ggacgactgc gggagtaggg caccagacga tgggcgtcca gcgcagccag ggtccggtcc     8880

ttccagggcc gcagcgtccg cgtcagggtg gtctccgtca cggtgaaggg gtgcgcgccg     8940

ggctgggcgc ttgcgagggt gcgcttcagg ctcatccggc tggtcgaaaa ccgctcccga     9000

tcggcgccct gcgcgtcggc caggtagcaa ttgaccatga gttcgtagtt gagcgcctcg     9060

gccgcgtggc ctttggcgcg gagcttacct ttggaagtct gcccgcaggc gggacagagg     9120

agggacttga gggcgtagag cttgggggcg aggaagacgg aatcgggggc gtaggcgtcc     9180

gcgccgcagt gggcgcagac ggtctcgcac tccacgagcc aggtgaggtc gggctggtcg     9240

gggtcaaaaa ccagtttccc gccgttcttt ttgatgcgtt tcttaccttt ggtctccatg     9300

agctcgtgtc cccgctgggt gacaaagagg ctgtccgtgt ccccgtagac cgactttatg     9360

ggccggtcct cgagcggtgt gccgcggtcc tcctcgtaga ggaaccccgc ccactccgag     9420

acgaaagccc gggtccaggc cagcacgaag gaggccacgt gggacgggta gcggtcgttg     9480

tccaccagcg ggtccacttt ttccagggta tgcaaacaca tgtccccctc gtccacatcc     9540

aggaaggtga ttggcttgta agtgtaggcc acgtgaccgg gggtcccggc cgggggggta     9600

taaaaggggg cgggcccctg ctcgtcctca ctgtcttccg gatcgctgtc caggagcgcc     9660

agctgttggg gtaggtattc cctctcgaag gcgggcatga cctcggcact caggttgtca     9720

gtttctagaa acgaggagga tttgatattg acggtgccag cggagatgcc tttcaagagc     9780

ccctcgtcca tctggtcaga aaagacgatt tttttgttgt cgagcttggt ggcgaaggag     9840

ccgtagaggg cgttggaaag gagcttggcg atggagcgca tggtctggtt tttttccttg     9900

tcggcgcgct ccttggccgc gatgttgagc tgcacgtact cgcgcgccac gcacttccat     9960

tcggggaaga cggtggtcat ctcgtcgggc acgattctga cctgccaacc tcgattatgc    10020

agggtgatga ggtccacact ggtggccacc tcgccgcgca ggggctcgtt ggtccagcag    10080

aggcggccgc ccttgcgcga gcagaagggg ggcagagggt ccagcatgac ctcgtcgggg    10140

gggtcggcat cgatggtgaa gatgccgggc aggagatcgg ggtcgaagta gctgatggaa    10200

gtggccagat cgtccaggga agcttgccat tcgcgcacgg ccagcgcgcg ctcgtaggga    10260

ctgaggggcg tgccccaggg catggggtgg gtgagcgcgg aggcgtacat gccgcagatg    10320

tcgtagacgt agaggggctc ctcgaggatg ccgatgtagg tggggtagca gcgccccccg    10380

cggatgctgg cgcgcacgta gtcatacagc tcgtgcgagg gcgcgaggag ccccgggccc    10440

aggttggtgc gactgggctt ttcggcgcgg tagacgatct ggcgaaagat ggcatgcgag    10500

ttggaggaga tggtgggcct ttggaagatg ttgaagtggg cgtgggggag gccgaccgag    10560

tcgcggatga agtgggcgta ggagtcttgc agtttggcga cgagctcggc ggtgacgagg    10620

acgtccagag cgcagtagtc gagggtctcc tggatgatgt catacttgag ctggcccttt    10680

tgtttccaca gctcgcggtt gagaaggaac tcttcgcggt ccttccagta ctcttcgagg    10740

gggaacccgt cctgatctgc acggtaagag cctagcatgt agaactggtt gacggccttg    10800

taggcgcagc agcccttctc cacggggagg gcgtaggcct gggcggcctt gcgcagggag    10860

gtgtgcgtga gggcgaaggt gtccctgacc atgaccttga ggaactggtg cttgaaatcg    10920

atatcgtcgc agcccccctg ctcccagagc tggaagtccg tgcgcttctt gtaggcgggg    10980

ttgggcaaag cgaaagtaac atcgttgaaa aggatcttgc ccgcgcgggg cataaagttg    11040

cgagtgatgc ggaaaggctg gggcacctcg gcccggttgt tgatgacctg ggcggcgagc    11100

acgatctcgt cgaaaccgtt gatgttgtgg cccacgatgt agagttccac gaatcgcggg    11160

cggcccttga cgtggggcag cttcttgagc tcctcgtagg tgagctcgtc ggggtcgctg    11220

agaccgtgct gctcgagcgc ccagtcggcg agatgggggt tggcgcggag gaaggaagtc    11280

cagagatcca cggccagggc ggtttgcaga cggtcccggt actgacggaa ctgctgcccg    11340

acggccattt tttcgggggt gacgcagtag aaggtgcggg ggtccccgtg ccagcggtcc    11400

catttgagct ggagggcgag atcgagggcg agctcgacga ggcggtcgtc ccctgagagt    11460

ttcatgacca gcatgaaggg gacgagctgc ttgccgaagg accccatcca ggtgtaggtt    11520

tccacatcgt aggtgaggaa gagcctttcg gtgcgaggat gcgagccgat ggggaagaac    11580

tggatctcct gccaccaatt ggaggaatgg ctgttgatgt gatggaagta gaaatgccga    11640

cggcgcgccg aacactcgtg cttgtgttta tacaagcggc cacagtgctc gcaacgctgc    11700

acgggatgca cgtgctgcac gagctgtacc tgagttcctt tgacgaggaa tttcagtggg    11760

aagtggagtc gtggcgcctg catctcgtgc tgtactacgt cgtggtggtc ggcctggccc    11820

tcttctgcct cgatggtggt catgctgacg agcccgcgcg ggaggcaggt ccagacctcg    11880

gcgcgagcgg gtcggagagc gaggacgagg gcgcgcaggc cggagctgtc cagggtcctg    11940

agacgctgcg gagtcaggtc agtgggcagc ggcggcgcgc ggttgacttg caggagtttt    12000

tccagggcgc gcgggaggtc cagatggtac ttgatctcca ccgcgccgtt ggtggcgacg    12060

tcgatggctt gcagggtccc gtgcccctgg ggtgtgacca ccgtcccccg tttcttcttg    12120

ggcggctggg gcgacggggg cggtgcctct tccatggtta gaagcggcgg cgaggacgcg    12180

cgccgggcgg cagaggcggc tcggggcccg gaggcagggg cggcaggggc acgtcggcgc    12240

cgcgcgcggg taggttctgg tactgcgccc ggagaagact ggcgtgagcg acgacgcgac    12300

ggttgacgtc ctggatctga cgcctctggg tgaaggccac gggacccgtg agtttgaacc    12360

tgaaagagag ttcgacagaa tcaatctcgg tatcgttgac ggcggcctgc cgcaggatct    12420

cttgcacgtc gcccgagttg tcctggtagg cgatctcggt catgaactgc tcgatctcct    12480

cctcctgaag gtctccgcga ccggcgcgct ccacggtggc cgcgaggtcg ttggagatgc    12540

ggcccatgag ctgcgagaag gcgttcatgc ccgcctcgtt ccagacgcgg ctgtagacca    12600

cgacgccctc gggatcgcgg gcgcgcatga ccacctgggc gaggttgagc tccacgtggc    12660

gcgtgaagac cgcgtagttg cagaggcgct ggtagaggta gttgagcgtg gtggcgatgt    12720

gctcggtgac gaagaaatac atgatccagc ggcggagcgg catctcgctg acgtcgccca    12780

gcgcctccaa gcgttccatg gcctcgtaaa agtccacggc gaagttgaaa aactgggagt    12840

tgcgcgccga gacggtcaac tcctcctcca gaagacggat gagctcggcg atggtggcgc    12900

gcacctcgcg ctcgaaggcc cccgggagtt cctccacttc ctcctcttct tcctcctcca    12960

ctaacatctc ttctacttcc tcctcaggcg gtggtggtgg cgggggaggg ggcctgcgtc    13020

gccggcggcg cacgggcaga cggtcgatga agcgctcgat ggtctcgccg cgccggcgtc    13080

gcatggtctc ggtgacggcg cgcccgtcct cgcggggccg cagcgtgaag acgccgccgc    13140

gcatctccag gtggccgggg gggtccccgt tgggcaggga gagggcgctg acgatgcatc    13200

ttatcaattg ccccgtaggg actccgcgca aggacctgag cgtctcgaga tccacgggat    13260

ctgaaaaccg ttgaacgaag gcttcgagcc agtcgcagtc gcaaggtagg ctgagcacgg    13320

tttcttctgc cgggtcatgt tggggagcgg ggcgggcgat gctgctggtg atgaagttga    13380

aataggcggt tctgagacgg cggatggtgg cgaggagcac caggtctttg ggcccggctt    13440

gctggatgcg cagacggtcg gccatgcccc aggcgtggtc ctgacacctg gccaggtcct    13500

tgtagtagtc ctgcatgagc cgctccacgg gcacctcctc ctcgcccgcg cggccgtgca    13560

tgcgcgtgag cccgaagccg cgctggggct ggacgagcgc caggtcggcg acgacgcgct    13620

cggcgaggat ggcctgctgg atctgggtga gggtggtctg gaagtcgtca aagtcgacga    13680

agcggtggta ggctccggtg ttgatggtgt aggagcagtt ggccatgacg gaccagttga    13740

cggtctggtg gcccggacgc acgagctcgt ggtacttgag gcgcgagtag gcgcgcgtgt    13800

cgaagatgta gtcgttgcag gtgcgcacca ggtactggta gccgatgagg aagtgcggcg    13860

gcggctggcg gtagagcggc catcgctcgg tggcgggggc gccgggcgcg aggtcctcga    13920

gcatggtgcg gtggtagccg tagatgtacc tggacatcca ggtgatgccg gcggcggtgg    13980

tggaggcgcg cgggaactcg cggacgcggt tccagatgtt gcgcagcggc aggaagtagt    14040

tcatggtggg cacggtctgg cccgtgaggc gcgcgcagtc gtggatgctc tatacgggca    14100

aaaacgaaag cggtcagcgg ctcgactccg tggcctggag gctaagcgaa cgggttgggc    14160

tgcgcgtgta ccccggttcg aatctcgaat caggctggag ccgcagctaa cgtggtactg    14220

gcactcccgt ctcgacccaa gcctgcacca accctccagg atacggaggc gggtcgtttt    14280

gcaacttttt ttggaggccg gaaatgaaac tagtaagcgc ggaaagcggc cgaccgcgat    14340

ggctcgctgc cgtagtctgg agaagaatcg ccagggttgc gttgcggtgt gccccggttc    14400

gaggccggcc ggattccgcg gctaacgagg gcgtggctgc cccgtcgttt ccaagacccc    14460

atagccagcc gacttctcca gttacggagc gagcccctct tttgttttgt ttgtttttgc    14520

cagatgcatc ccgtactgcg gcagatgcgc ccccaccacc ctccaccgca acaacagccc    14580

cctcctccac agccggcgct tctgcccccg ccccagcagc agcagcaact tccagccacg    14640

accgccgcgg ccgccgtgag cggggctgga cagacttctc agtatgatca cctggccttg    14700

gaagagggcg aggggctggc gcgcctgggg gcgtcgtcgc cggagcggca cccgcgcgtg    14760

cagatgaaaa gggacgctcg cgaggcctac gtgcccaagc agaacctgtt cagagacagg    14820

agcggcgagg agcccgagga gatgcgcgcg gcccggttcc acgcggggcg ggagctgcgg    14880

cgcggcctgg accgaaagag ggtgctgagg gacgaggatt tcgaggcgga cgagctgacg    14940

gggatcagcc ccgcgcgcgc gcacgtggcc gcggccaacc tggtcacggc gtacgagcag    15000

accgtgaagg aggagagcaa cttccaaaaa tccttcaaca accacgtgcg caccctgatc    15060

gcgcgcgagg aggtgaccct gggcctgatg cacctgtggg acctgctgga ggccatcgtg    15120

cagaacccca ccagcaagcc gctgacggcg cagctgttcc tggtggtgca gcatagtcgg    15180

gacaacgagg cgttcaggga ggcgctgctg aatatcaccg agcccgaggg ccgctggctc    15240

ctggacctgg tgaacattct gcagagcatc gtggtgcagg agcgcgggct gccgctgtcc    15300

gagaagctgg cggccatcaa cttctcggtg ctgagtctgg gcaagtacta cgctaggaag    15360

atctacaaga ccccgtacgt gcccatagac aaggaggtga agatcgacgg gttttacatg    15420

cgcatgaccc tgaaagtgct gaccctgagc gacgatctgg gggtgtaccg caacgacagg    15480

atgcaccgcg cggtgagcgc cagcaggcgg cgcgagctga gcgaccagga gctgatgcac    15540

agcctgcagc gggccctgac cggggccggg accgaggggg agagctactt tgacatgggc    15600

gcggacctgc actggcagcc cagccgccgg gccttggagg cggcaggcgg tcccccctac    15660

atagaagagg tggacgatga ggtggacgag gagggcgagt acctggaaga ctgatggcgc    15720

gaccgtattt ttgctagatg caacaacagc cacctcctga tcccgcgatg cgggcggcgc    15780

tgcagagcca gccgtccggc attaactcct cggacgattg gacccaggcc atgcaacgca    15840

tcatggcgct gacgacccgc aaccccgaag cctttagaca gcagccccag gccaaccggc    15900

tctcggccat cctggaggcc gtggtgccct cgcgctccaa ccccacgcac gagaaggtcc    15960

tggccatcgt gaacgcgctg gtggagaaca aggccatccg cggcgacgag gccggcctgg    16020

tgtacaacgc gctgctggag cgcgtggccc gctacaacag caccaacgtg cagaccaacc    16080

tggaccgcat ggtgaccgac gtgcgcgagg ccgtggccca gcgcgagcgg ttccaccgcg    16140

agtccaacct gggatccatg gtggcgctga acgccttcct cagcacccag cccgccaacg    16200

tgccccgggg ccaggaggac tacaccaact tcatcagcgc cctgcgcctg atggtgaccg    16260

aggtgcccca gagcgaggtg taccagtccg ggccggacta cttcttccag accagtcgcc    16320

agggcttgca gaccgtgaac ctgagccagg cgttcaagaa cttgcagggc ctgtggggcg    16380

tgcaggcccc ggtcggggac cgcgcgacgg tgtcgagcct gctgacgccg aactcgcgcc    16440

tgctgctgct gctggtggcc cccttcacgg acagcggcag catcaaccgc aactcgtacc    16500

tgggctacct gattaacctg taccgcgagg ccatcggcca ggcgcacgtg gacgagcaga    16560

cctaccagga gatcacccac gtgagccgcg ccctgggcca ggacgacccg ggcaatctgg    16620

aagccaccct gaactttttg ctgaccaacc ggtcgcagaa gatcccgccc cagtacacgc    16680

tcagcgccga ggaggagcgc atcctgcgat acgtgcagca gagcgtgggc ctgttcctga    16740

tgcaggaggg ggccaccccc agcgccgcgc tcgacatgac cgcgcgcaac atggagccca    16800

gcatgtacgc cagcaaccgc ccgttcatca ataaactgat ggactacttg catcgggcgg    16860

ccgccatgaa ctctgactat ttcaccaacg ccatcctgaa tccccactgg ctcccgccgc    16920

cggggttcta cacgggcgag tacgacatgc ccgaccccaa tgacgggttc ctgtgggacg    16980

atgtggacag cagcgtgttc tccccccgac cgggtgctaa cgagcgcccc ttgtggaaga    17040

aggaaggcag cgaccgacgc ccgtcctcgg cgctgtccgg ccgcgagggt gctgccgcgg    17100

cggtgcccga ggccgccagt cctttcccga gcttgccctt ctcgctgaac agtattcgca    17160

gcagcgagct gggcaggatc acgcgcccgc gcttgctggg cgaggaggag tacttgaatg    17220

actcgctgtt gagacccgag cgggagaaga acttccccaa taacgggata gagagcctgg    17280

tggacaagat gagccgctgg aagacgtatg cgcaggagca cagggacgat ccgtcgcagg    17340

gggccacgag ccggggcagc gccgcccgta aacgccggtg gcacgacagg cagcggggac    17400

tgatgtggga cgatgaggat tccgccgacg acagcagcgt gttggacttg ggtgggagtg    17460

gtaacccgtt cgctcacctg cgcccccgca tcgggcgcat gatgtaagag aaaccgaaaa    17520

taaatgatac tcaccaaggc catggcgacc agcgtgcgtt cgtttcttct ctgttgttgt    17580

atctagtatg atgaggcgtg cgtacccgga gggtcctcct ccctcgtacg agagcgtgat    17640

gcagcaggcg atggcggcgg cggcggcgat gcagcccccg ctggaggctc cttacgtgcc    17700

cccgcggtac ctggcgccta cggaggggcg gaacagcatt cgttactcgg agctggcacc    17760

cttgtacgat accacccggt tgtacctggt ggacaacaag tcggcggaca tcgcctcgct    17820

gaactaccag aacgaccaca gcaacttcct gaccaccgtg gtgcagaaca atgacttcac    17880

ccccacggag gccagcaccc agaccatcaa ctttgacgag cgctcgcggt ggggcggtca    17940

gctgaaaacc atcatgcaca ccaacatgcc caacgtgaac gagttcatgt acagcaacaa    18000

gttcaaggcg cgggtgatgg tctcccgcaa gacccccaac ggggtgacag tgacagatgg    18060

tagtcaggat atcttggagt atgaatgggt ggagtttgag ctgcccgaag gcaacttctc    18120

ggtgaccatg accatcgacc tgatgaacaa cgccatcatc gacaattact tggcggtggg    18180

gcggcagaac ggggtcctgg agagcgatat cggcgtgaag ttcgacacta ggaacttcag    18240

gctgggctgg gaccccgtga ccgagctggt catgcccggg gtgtacacca acgaggcctt    18300

ccaccccgat attgtcttgc tgcccggctg cggggtggac ttcaccgaga gccgcctcag    18360

caacctgctg ggcattcgca agaggcagcc cttccaggag ggcttccaga tcatgtacga    18420

ggatctggag gggggcaaca tccccgcgct cctggatgtc gacgcctatg agaaaagcaa    18480

ggaggagagc gccgccgcgg cgactgcagc tgtagccacc gcctctaccg aggtcagggg    18540

cgataatttt gccagccctg cagcagtggc agcggccgag gcggctgaaa ccgaaagtaa    18600

gatagtcatt cagccggtgg agaaggatag caaggacagg agctacaacg tgctgccgga    18660

caagataaac accgcctacc gcagctggta cctggcctac aactatggcg accccgagaa    18720

gggcgtgcgc tcctggacgc tgctcaccac ctcggacgtc acctgcggcg tggagcaagt    18780

ctactggtcg ctgcccgaca tgatgcaaga cccggtcacc ttccgctcca cgcgtcaagt    18840

tagcaactac ccggtggtgg gcgccgagct cctgcccgtc tactccaaga gcttcttcaa    18900

cgagcaggcc gtctactcgc agcagctgcg cgccttcacc tcgctcacgc acgtcttcaa    18960

ccgcttcccc gagaaccaga tcctcgtccg cccgcccgcg cccaccatta ccaccgtcag    19020

tgaaaacgtt cctgctctca cagatcacgg gaccctgccg ctgcgcagca gtatccgggg    19080

agtccagcgc gtgaccgtta ctgacgccag acgccgcacc tgcccctacg tctacaaggc    19140

cctgggcata gtcgcgccgc gcgtcctctc gagccgcacc ttctaaaaaa tgtccattct    19200

catctcgccc agtaataaca ccggttgggg cctgcgcgcg cccagcaaga tgtacggagg    19260

cgctcgccaa cgctccacgc aacaccccgt gcgcgtgcgc gggcacttcc gcgctccctg    19320

gggcgccctc aagggccgcg tgcggtcgcg caccaccgtc gacgacgtga tcgaccaggt    19380

ggtggccgac gcgcgcaact acacccccgc cgccgcgccc gtctccaccg tggacgccgt    19440

catcgacagc gtggtggccg acgcgcgccg gtacgcccgc gccaagagcc ggcggcggcg    19500

catcgcccgg cggcaccgga gcacccccgc catgcgcgcg gcgcgagcct tgctgcgcag    19560

ggccaggcgc acgggacgca gggccatgct cagggcggcc agacgcgcgg cttcaggcgc    19620

cagcgccggc aggacccgga gacgcgcggc cacggcggcg gcagcggcca tcgccagcat    19680

gtcccgcccg cggcgaggga acgtgtactg ggtgcgcgac gccgccaccg gtgtgcgcgt    19740

gcccgtgcgc acccgccccc ctcgcacttg aagatgttca cttcgcgatg ttgatgtgtc    19800

ccagcggcga ggaggatgtc caagcgcaaa ttcaaggaag agatgctcca ggtcatcgcg    19860

cctgagatct acggccccgc ggtggtgaag gaggaaagaa agccccgcaa aatcaagcgg    19920

gtcaaaaagg acaaaaagga agaagatgac gatctggtgg agtttgtgcg cgagttcgcc    19980

ccccggcggc gcgtgcagtg gcgcgggcgg aaagtgcacc cggtgctgag acccggcacc    20040

accgtggtct tcacgcccgg cgagcgctcc ggcagcgctt ccaagcgctc ctacgacgag    20100

gtgtacgggg acgaggacat cctcgagcag gcggccgagc gcctgggcga gtttgcttac    20160

ggcaagcgca gccgccccgc cctgaaggaa gaggcggtgt ccatcccgct ggaccacggc    20220

aaccccacgc cgagcctcaa gcccgtgacc ctgcagcagg tgctgccgag cgcagcgccg    20280

cgccgggggt tcaagcgcga gggcgaggat ctgtacccca ccatgcagct gatggtgccc    20340

aagcgccaga agctggaaga cgtgctggag accatgaagg tggacccgga cgtgcagccc    20400

gaggtcaagg tgcggcccat caagcaggtg gccccgggcc tgggcgtgca gaccgtggac    20460

atcaagatcc ccacggagcc catggaaacg cagaccgagc ccatgatcaa gcccagcacc    20520

agcaccatgg aggtgcagac ggatccctgg atgccatcgg ctcctagccg aagaccccgg    20580

cgcaagtacg gcgcggccag cctgctgatg cccaactacg cgctgcatcc ttccatcatc    20640

cccacgccgg gctaccgcgg cacgcgcttc taccgcggtc atacaaccag ccgccgccgc    20700

aagaccacca cccgccgccg ccgtcgccgc acagccgctg catctacccc tgccgccctg    20760

gtgcggagag tgtaccgccg cggccgcgcg cctctgaccc taccgcgcgc gcgctaccac    20820

ccgagcatcg ccatttaaac tttcgcctgc tttgcagatg gccctcacat gccgcctccg    20880

cgttcccatt acgggctacc gaggaagaaa accgcgccgt agaaggctgg cggggaacgg    20940

gatgcgtcgc caccaccatc ggcggcggcg cgccatcagc aagcggttgg ggggaggctt    21000

cctgcccgcg ctgatcccca tcatcgccgc ggcgatcggg gcgatccccg gcattgcttc    21060

cgtggcggtg caggcctctc agcgccactg agacacttgg aaaacatctt gtaataaacc    21120

aatggactct gacgctcctg gtcctgtgat gtgttttcgt agacagatgg aagacatcaa    21180

tttttcgtcc ctggctccgc gacacggcac gcggccgttc atgggcacct ggagcgacat    21240

cggcaccagc caactgaacg ggggcgcctt caattggagc agtctctgga gcgggcttaa    21300

gaatttcggg tccacgctta aaacctatgg cagcaaggcg tggaacagca ccacagggca    21360

ggcgctgagg gataagctga aagagcagaa cttccagcag aaggtggtcg atgggctcgc    21420

ctcgggcatc aacggggtgg tggacctggc caaccaggcc gtgcagcggc agatcaacag    21480

ccgcctggac ccggtgccgc ccgccggctc cgtggagatg ccgcaggtgg aggaggagct    21540

gcctcccctg gacaagcggg gcgagaagcg accccgcccc gacgcggagg agacgctgct    21600

gacgcacacg gacgagccgc ccccgtacga ggaggcggtg aaactgggtc tgcccaccac    21660

gcggcccatc gcgcccctgg ccaccggggt gctgaaaccc gaaagtaata agcccgcgac    21720

cctggacttg cctcctcccg cttcccgccc ctctacagtg gctaagcccc tgccgccggt    21780

ggccgtggcc cgcgcgcgac ccgggggctc cgcccgccct catgcgaact ggcagagcac    21840

tctgaacagc atcgtgggtc tgggagtgca gagtgtgaag cgccgccgct gctattaaac    21900

ctaccgtagc gcttaacttg cttgtctgtg tgtgtatgta ttatgtcgcc gctgtccgcc    21960

agaaggagga gtgaagaggc gcgtcgccga gttgcaagat ggccacccca tcgatgctgc    22020

cccagtgggc gtacatgcac atcgccggac aggacgcttc ggagtacctg agtccgggtc    22080

tggtgcagtt cgcccgcgcc acagacacct acttcagtct ggggaacaag tttaggaacc    22140

ccacggtggc gcccacgcac gatgtgacca ccgaccgcag ccagcggctg acgctgcgct    22200

tcgtgcccgt ggaccgcgag gacaacacct actcgtacaa agtgcgctac acgctggccg    22260

tgggcgacaa ccgcgtgctg gacatggcca gcacctactt tgacatccgc ggcgtgctgg    22320

atcggggccc tagcttcaaa ccctactccg gcaccgccta caacagcctg gctcccaagg    22380

gagcgcccaa ttccagccag tgggagcaaa aaaaggcagg caatggtgac actatggaaa    22440

cacacacatt tggtgtggcc ccaatgggcg gtgagaatat tacaatcgac ggattacaaa    22500

ttggaactga cgctacagct gatcaggata aaccaattta tgctgacaaa acattccagc    22560

ctgaacctca agtaggagaa gaaaattggc aagaaactga aagcttttat ggcggtaggg    22620

ctcttaaaaa agacacaagc atgaaacctt gctatggctc ctatgctaga cccaccaatg    22680

taaagggagg tcaagctaaa cttaaagttg gagctgatgg agttcctacc aaagaatttg    22740

acatagacct ggctttcttt gatactcccg gtggcacagt gaatggacaa gatgagtata    22800

aagcagacat tgtcatgtat accgaaaaca cgtatctgga aactccagac acgcatgtgg    22860

tatacaaacc aggcaaggat gatgcaagtt ctgaaattaa cctggttcag cagtccatgc    22920

ccaatagacc caactatatt gggttcagag acaactttat tgggctcatg tattacaaca    22980

gtactggcaa tatgggggtg ctggctggtc aggcctcaca gctgaatgct gtggtcgact    23040

tgcaagacag aaacaccgag ctgtcatacc agctcttgct tgactctttg ggtgacagaa    23100

cccggtattt cagtatgtgg aatcaggcgg tggacagtta tgatcctgat gtgcgcatta    23160

ttgaaaacca tggtgtggaa gacgaacttc ccaactattg cttccccctg gatgggtctg    23220

gcactaatgc cgcttaccaa ggtgtgaaag taaaaaatgg taacgatggt gatgttgaga    23280

gcgaatggga aaatgatgat actgtcgcag ctcgaaatca attatgcaag ggcaacattt    23340

ttgccatgga aattaacctc caagccaacc tgtggagaag tttcctctac tcgaacgtgg    23400

ccctgtacct gcccgactct tacaagtaca cgccagccaa catcaccctg cccaccaaca    23460

ccaacactta tgattacatg aacgggagag tggtgcctcc ctcgctggtg gacgcctaca    23520

tcaacatcgg ggcgcgctgg tcgctggacc ccatggacaa cgtcaatccc ttcaaccacc    23580

accgcaacgc gggcctgcgc taccgctcca tgctcctggg caacgggcgc tacgtgccct    23640

tccacatcca ggtgccccag aaatttttcg ccatcaagag cctcctgctc ctgcccgggt    23700

cctacaccta cgagtggaac ttccgcaagg acgtcaacat gatcctgcag agctccctcg    23760

gcaacgacct gcgcacggac ggggcctcca tctccttcac cagcatcaac ctctacgcca    23820

ccttcttccc catggcgcac aacacggcct ccacgctcga ggccatgctg cgcaacgaca    23880

ccaacgacca gtccttcaac gactacctct cggcggccaa catgctctac cccatcccgg    23940

ccaacgccac caacgtgccc atctccatcc cctcgcgcaa ctgggccgcc ttccgcggct    24000

ggtccttcac gcgcctcaag accaaggaga cgccctcgct gggctccggg ttcgacccct    24060

acttcgtcta ctcgggctcc atcccctacc tcgacggcac cttctacctc aaccacacct    24120

tcaagaaggt ctccatcacc ttcgactcct ccgtcagctg gcccggcaac gaccggctcc    24180

tgacgcccaa cgagttcgaa atcaagcgca ccgtcgacgg cgagggatac aacgtggccc    24240

agtgcaacat gaccaaggac tggttcctgg tccagatgct ggcccactac aacatcggct    24300

accagggctt ctacgtgccc gagggctaca aggaccgcat gtactccttc ttccgcaact    24360

tccagcccat gagccgccag gtggtggacg aggtcaacta caaggactac caggccgtca    24420

ccctggccta ccagcacaac aactcgggct tcgtcggcta cctcgcgccc accatgcgcc    24480

agggccagcc ctaccccgcc aactacccgt acccgctcat cggcaagagc gccgtcacca    24540

gcgtcaccca gaaaaagttc ctctgcgaca gggtcatgtg gcgcatcccc ttctccagca    24600

acttcatgtc catgggcgcg ctcaccgacc tcggccagaa catgctctat gccaactccg    24660

cccacgcgct agacatgaat ttcgaagtcg accccatgga tgagtccacc cttctctatg    24720

ttgtcttcga agtcttcgac gtcgtccgag tgcaccagcc ccaccgcggc gtcatcgagg    24780

ccgtctacct gcgcaccccc ttctcggccg gtaacgccac cacctaaatt gctacttgca    24840

tgatggctga gcccacaggc tccggcgagc aggagctcag ggccatcatc cgcgacctgg    24900

gctgcgggcc ctacttcctg ggcaccttcg ataagcgctt cccgggattc atggccccgc    24960

acaagctggc ctgcgccatc gtcaacacgg ccggccgcga gaccgggggc gagcactggc    25020

tggccttcgc ctggaacccg cgctcgaaca cctgctacct cttcgacccc ttcgggttct    25080

cggacgagcg cctcaagcag atctaccagt tcgagtacga gggcctgctg cgccgtagcg    25140

ccctggccac cgaggaccgc tgcgtcaccc tggaaaagtc cacccagacc gtgcagggtc    25200

cgcgctcggc cgcctgcggg ctcttctgct gcatgttcct gcacgccttc gtgcactggc    25260

ccgaccgccc catggacaag aaccccacca tgaacttgct gacgggggtg cccaacggca    25320

tgctccagtc gccccaggtg gaacccaccc tgcgccgcaa ccaggaggcg ctctaccgct    25380

tcctcaactc ccactccgcc tactttcgct cccaccgcgc gcgcatcgag aaggccaccg    25440

ccttcgaccg catgaacaat caagacatgt aaaccgtgtg tgtatgttta aaatatcttt    25500

taataaacag cactttaatg ttacacatgc atctgagatg attttatttt agaaatcgaa    25560

agggttctgc cgggtctcgg catggcccgc gggcagggac acgttgcgga actggtactt    25620

ggccagccac ttgaactcgg ggatcagcag tttgggcagc ggggtgtcgg ggaaggagtc    25680

ggtccacagc ttccgcgtca gctgcagggc gcccagcagg tcgggcgcgg agatcttgaa    25740

atcgcagttg ggacccgcgt tctgcgcgcg agagttgcgg tacacggggt tgcagcactg    25800

gaacaccatc agggccgggt gcttcacgct cgccagcacc gccgcgtcgg tgatgctctc    25860

cacgtcgagg tcctcggcgt tggccatccc gaagggggtc atcttgcagg tctgccttcc    25920

catggtgggc acgcacccgg gcttgtggtt gcaatcgcag tgcaggggga tcagcatcat    25980

ctgggcctgg tcggcgttca tccccgggta catggccttc atgaaagcct ccaattgcct    26040

gaacgcctgc tgggccttgg ctccctcggt gaagaagacc ccgcaggact tgctagagaa    26100

ctggttggtg gcacagccgg catcgtgcac gcagcagcgc gcgtcgttgt tggccagctg    26160

caccacgctg cgcccccagc ggttctgggt gatcttggcc cggtcggggt tctccttcag    26220

cgcgcgctgc ccgttctcgc tcgccacatc catctcgatc atgtgctcct tctggatcat    26280

ggtggtcccg tgcaggcacc gcagtttgcc ctcggcctcg gtgcacccgt gcagccacag    26340

cgcgcacccg gtgcactccc agttcttgtg ggcgatctgg gaatgcgcgt gcacgaaccc    26400

ttgcaggaag cggcccatca tggtcgtcag ggtcttgttg ctagtgaagg tcaacgggat    26460

gccgcggtgc tcctcgttga tgtacaggtg gcagatgcgg cggtacacct cgccctgctc    26520

gggcatcagt tggaagttgg ctttcaggtc ggtctccacg cggtagcggt ccatcagcat    26580

agtcatgatt tccatgccct tctcccaggc cgagacgatg ggcaggctca tagggttctt    26640

caccatcatc ttagcactag cagccgcggc cagggggtcg ctctcatcca gggtctcaaa    26700

gctccgcttg ccgtccttct cggtgatccg caccgggggg tagctgaagc ccacggccgc    26760

cagctcctcc tcggcctgtc tttcgtcctc gctgtcctgg ctgacgtcct gcatgaccac    26820

atgcttggtc ttgcggggtt tcttcttggg cggcagtggc ggcggagatg cttgtggcga    26880

gggggagcgc gagttctcgc tcaccactac tatctcttcc tcttcttggt ccgaggccac    26940

gcggcggtag gtatgtctct tcgggggcag aggcggaggc gacgggctct cgccgccgcg    27000

acttggcgga tggctggcag agccccttcc gcgttcgggg gtgcgctccc ggcggcgctc    27060

tgactgactt cctccgcggc cggccattgt gttctcctag ggaggaacaa caagcatgga    27120

gactcagcca tcgccaacct cgccatctgc ccccaccgcc ggcgacgaga agcagcagca    27180

gcagaatgaa agcttaaccg ccccgccgcc cagccccgcc tccgacgcag ccgcggtccc    27240

agacatgcaa gagatggagg aatccatcga gattgacctg ggctatgtga cgcccgcgga    27300

gcatgaggag gagctggcag tgcgctttca atcgtcaagc caggaagata aagaacagcc    27360

agagcaggaa gcagagaacg agcagagtca ggctgggctc gagcatggcg actacctcca    27420

cctgagcggg gaggaggacg cgctcatcaa gcatctggcc cggcaggcca ccatcgtcaa    27480

ggacgcgctg ctcgaccgca ccgaggtgcc cctcagcgtg gaggagctca gccgcgccta    27540

cgagctcaac ctcttctcgc cgcgcgtgcc ccccaagcgc cagcccaacg gcacctgcga    27600

gcccaacccc cgcctcaact tctacccggt cttcgcggtg cccgaggccc tggccaccta    27660

ccacatcttt ttcaagaacc aaaagatccc cgtctcctgc cgcgccaacc gcacccgcgc    27720

cgacgccctc ttcaacctgg gtcccggcgc ccgcctacct gatatcgcct ccttggaaga    27780

ggttcccaag atcttcgagg gtctgggcag cgacgagact cgggccgcga acgctctgca    27840

aggagaagga ggaggagagc atgagcacca cagcgccctg gtcgagttgg aaggcgacaa    27900

cgcgcggctg gcggtgctca aacgcacggt cgagctgacc catttcgcct acccggctct    27960

gaacctgccc ccgaaagtca tgagcgcggt catggaccag gtgctcatca agcgcgcgtc    28020

gcccatctcc gaggacgagg gcatgcaaga ctccgaggag ggcaagcccg tggtcagcga    28080

cgagcagctg gcccggtggc tgggtcctaa tgctacccct caaagtttgg aagagcggcg    28140

caagctcatg atggccgtgg tcctggtgac cgtggagctg gagtgcctgc gccgcttctt    28200

cgccgacgcg gagaccctgc gcaaggtcga ggagaacctg cactacctct tcaggcacgg    28260

gttcgtgcgc caggcctgca agatctccaa cgtggagctg accaacctgg tctcctacat    28320

gggcatcttg cacgagaacc gcctggggca gaacgtgctg cacaccaccc tgcgcgggga    28380

ggcccgccgc gactacatcc gcgactgcgt ctacctctac ctctgccaca cctggcagac    28440

gggcatgggc gtgtggcagc agtgtctgga ggagcagaac ctgaaagagc tctgcaagct    28500

cctgcaaaag aacctcaagg gtctgtggac cgggttcgac gagcggacca ccgcctcgga    28560

cctggccgac ctcatcttcc ccgagcgcct caggctgacg ctgcgcaacg gcctgcccga    28620

ctttatgagc caaagcatgt tgcaaaactt tcgctctttc atcctcgaac gctccggaat    28680

cctgcccgcc acctgctccg cgctgccctc ggacttcgtg ccgctgacct tccgcgagtg    28740

ccccccgccg ctgtggagcc actgctacct gctgcgcctg gccaactacc tggcctacca    28800

ctcggacgtg atcgaggacg tcagcggcga gggcctgctc gagtgccact gccgctgcaa    28860

cctctgcacg ccgcaccgct ccctggcctg caacccccag ctgctgagcg agacccagat    28920

catcggcacc ttcgagttgc aagggcccag cgagggcgag ggagccaagg ggggtctgaa    28980

actcaccccg gggctgtgga cctcggccta cttgcgcaag ttcgtgcccg aggattacca    29040

tcccttcgag atcaggttct acgaggacca atcccagccg cccaaggccg agctgtcggc    29100

ctgcgtcatc acccaggggg cgatcctggc ccaattgcaa gccatccaga aatcccgcca    29160

agaattcttg ctgaaaaagg gccgcggggt ctacctcgac ccccagaccg gtgaggagct    29220

caaccccggc ttcccccagg atgccccgag gaaacaagaa gctgaaagtg gagctgccgc    29280

ccgtggagga tttggaggaa gactgggaga acagcagtca ggcagaggag atggaggaag    29340

actgggacag cactcaggca gaggaggaca gcctgcaaga cagtctggag gaagacgagg    29400

aggaggcaga ggaggaggtg gaagaagcag ccgccgccag accgtcgtcc tcggcggggg    29460

agaaagcaag cagcacggat accatctccg ctccgggtcg gggtcccgct cggccccaca    29520

gtagatggga cgagaccggg cgattcccga accccaccac ccagaccggt aagaaggagc    29580

ggcagggata caagtcctgg cgggggcaca aaaacgccat cgtctcctgc ttgcaggcct    29640

gcgggggcaa catctccttc acccggcgct acctgctctt ccaccgcggg gtgaacttcc    29700

cccgcaacat cttgcattac taccgtcacc tccacagccc ctactacttc caagaagagg    29760

cagcagcagc agaaaaagac cagaaaacca gctagaaaat ccacagcggc ggcagcggca    29820

ggtggactga ggatcgcggc gaacgagccg gcgcagaccc gggagctgag gaaccggatc    29880

tttcccaccc tctatgccat cttccagcag agtcgggggc aggagcagga actgaaagtc    29940

aagaaccgtt ctctgcgctc gctcacccgc agttgtctgt atcacaagag cgaagaccaa    30000

cttcagcgca ctctcgagga cgccgaggct ctcttcaaca agtactgcgc gctcactctt    30060

aaagagtagc ccgcgcccgc ccagtcgcag aaaaaggcgg gaattacgtc acctgtgccc    30120

ttcgccctag ccgcctccac ccagcaccgc catgagcaaa gagattccca cgccttacat    30180

gtggagctac cagccccaga tgggcctggc cgccggcgcc gcccaggact actccacccg    30240

catgaattgg ctcagcgccg ggcccgcgat gatctcacgg gtgaatgaca tccgcgccca    30300

ccgaaaccag atactcctag aacagtcagc gctcaccgcc acgccccgca atcacctcaa    30360

tccgcgtaat tggcccgccg ccctggtgta ccaggaaatt ccccagccca cgaccgtact    30420

acttccgcga gacgcccagg ccgaagtcca gctgactaac tcaggtgtcc agctggcggg    30480

cggcgccacc ctgtgtcgtc accgccccgc tcagggtata aagcggctgg tgatccgggg    30540

cagaggcaca cagctcaacg acgaggtggt gagctcttcg ctgggtctgc gacctgacgg    30600

agtcttccaa ctcgccggat cggggagatc ttccttcacg cctcgtcagg cggtcctgac    30660

tttggagagt tcgtcctcgc agccccgctc gggcggcatc ggcactctcc agttcgtgga    30720

ggagttcact ccctcggtct acttcaaccc cttctccggc tcccccggcc actacccgga    30780

cgagttcatc ccgaactttg acgccatcag cgagtcggtg gacggctacg attgattaat    30840

taatcaacta accccttacc cctttaccct ccagtaaaaa taaagattaa aaatgattga    30900

attgatcaat aaagaatcac ttacttgaaa tctgaaacca ggtctctgtc catgttttct    30960

gtcagcagca cttcactccc ctcttcccaa ctctggtact gcaggccccg gcgggctgca    31020

aacttcctcc acactctgaa ggggatgtca aattcctcct gtccctcaat cttcattttt    31080

atcttctatc agatgtccaa aaagcgcgcg cgggtggatg atggcttcga ccccgtgtac    31140

ccctacgatg cagacaacgc accgactgtg cccttcatca accctccctt cgtctcttca    31200

gatggattcc aagaaaagcc cctgggggtg ttgtccctgc gactggccga ccccgtcacc    31260

accaagaatg gggctgtcac cctcaagctg ggggaggggg tggacctcga cgactcggga    31320

aaactcatct ccaaaaatgc caccaaggcc actgcccctc tcagtatttc caacggcacc    31380

atttccctta acatggctgc ccctttttac aacaacaatg gaacgttaag tctcaatgtt    31440

tctacaccat tagcagtatt tcccactttt aacactttag gtatcagtct tggaaacggt    31500

cttcaaactt ctaataagtt gctgactgta cagttaactc atcctcttac attcagctca    31560

aatagcatca cagtaaaaac agacaaagga ctctatatta attctagtgg aaacagaggg    31620

cttgaggcta acataagcct aaaaagagga ctgatttttg atggtaatgc tattgcaaca    31680

taccttggaa gtggtttaga ctatggatcc tatgatagcg atgggaaaac aagacccatc    31740

atcaccaaaa ttggagcagg tttgaatttt gatgctaata atgccatggc tgtgaagcta    31800

ggcacaggtt taagttttga ctctgccggt gccttaacag ctggaaacaa agaggatgac    31860

aagctaacac tttggactac acctgaccca agccctaatt gtcaattact ttcagacaga    31920

gatgccaaat ttaccctatg tcttacaaaa tgcggtagtc aaatactagg cactgttgca    31980

gtagctgctg ttactgtagg ttcagcacta aatccaatta atgacacagt aaaaagcgcc    32040

atagtattcc ttagatttga ctctgacggt gtgctcatgt caaactcatc aatggtaggt    32100

gattactgga actttaggga aggacagacc acccaaagtg tggcctatac aaatgctgtg    32160

ggattcatgc ccaatctagg tgcatatcct aaaacccaaa gcaaaacacc aaaaaatagt    32220

atagtaagtc aggtatattt aaatggagaa actactatgc caatgacact gacaataact    32280

ttcaatggca ctgatgaaaa agacacaaca cctgtgagca cttactccat gacttttaca    32340

tggcagtgga ctggagacta taaggacaag aatattacct ttgctaccaa ctcctttact    32400

ttctcctaca tggcccaaga ataaaccctg catgccaacc ccattgttcc caccactatg    32460

gaaaactctg aagcagaaaa aaataaagtt caagtgtttt attgattcaa cagttttctc    32520

acagaaccct agtattcaac ctgccacctc cctcccaaca cacagagtac acagtccttt    32580

ctccccggct ggccttaaaa agcatcatat catgggtaac agacatattc ttaggtgtta    32640

tattccacac ggtttcctgt cgagccaaac gctcatcagt gatattaata aactccccgg    32700

gcagctcact taagttcatg tcgctgtcca gctgctgagc cacaggctgc tgtccaactt    32760

gcggttgctt aacgggcggc gaaggagaag tccacgccta catgggggta gagtcataat    32820

cgtgcatcag gatagggcgg tggtgctgca gcagcgcgcg aataaactgc tgccgccgcc    32880

gctccgtcct gcaggaatac aacatggcag tggtctcctc agcgatgatt cgcaccgccc    32940

gcagcataag gcgccttgtc ctccgggcac agcagcgcac cctgatctca cttaaatcag    33000

cacagtaact gcagcacagc accacaatat tgttcaaaat cccacagtgc aaggcgctgt    33060

atccaaagct catggcgggg accacagaac ccacgtggcc atcataccac aagcgcaggt    33120

agattaagtg gcgacccctc ataaacacgc tggacataaa cattacctct tttggcatgt    33180

tgtaattcac cacctcccgg taccatataa acctctgatt aaacatggcg ccatccacca    33240

ccatcctaaa ccagctggcc aaaacctgcc cgccggctat acactgcagg gaaccgggac    33300

tggaacaatg acagtggaga gcccaggact cgtaaccatg gatcatcatg ctcgtcatga    33360

tatcaatgtt ggcacaacac aggcacacgt gcatacactt cctcaggatt acaagctcct    33420

cccgcgttag aaccatatcc cagggaacaa cccattcctg aatcagcgta aatcccacac    33480

tgcagggaag acctcgcacg taactcacgt tgtgcattgt caaagtgtta cattcgggca    33540

gcagcggatg atcctccagt atggtagcgc gggtttctgt ctcaaaagga ggtagacgat    33600

ccctactgta cggagtgcgc cgagacaacc gagatcgtgt tggtcgtagt gtcatgccaa    33660

atggaacgcc ggacgtagtc atatttcctg aagcaaaacc aggtgcgggc gtgacaaaca    33720

gatctgcgtc tccggtctcg ccgcttagat cgctctgtgt agtagttgta gtatatccac    33780

tctctcaaag catccaggcg ccccctggct tcgggttcta tgtaaactcc ttcatgcgcc    33840

gctgccctga taacatccac caccgcagaa taagccacac ccagccaacc tacacattcg    33900

ttctgcgagt cacacacggg aggagcggga agagctggaa gaaccatgat taactttatt    33960

ccaaacggtc tcggagcact tcaaaatgca ggtcccggag gtggcacctc tcgcccccac    34020

tgtgttggtg gaaaataaca gccaggtcaa aggtgacacg gttctcgaga tgttccacgg    34080

tggcttccag caaagcctcc acgcgcacat ccagaaacaa gaggacagcg aaagcgggag    34140

cgttttctaa ttcctcaatc atcatattac actcctgcac catccccaga taattttcat    34200

ttttccagcc ttgaatgatt cgtattagtt cctgaggtaa atccaagcca gccatgataa    34260

aaagctcgcg cagagcgccc tccaccggca ttcttaagca caccctcata attccaagag    34320

attctgctcc tggttcacct gcagcagatt aacaatggga atatcaaaat ctctgccgcg    34380

atccctaagc tcctccctca acaataactg tatgtaatct ttcatatcat ctccgaaatt    34440

tttagccata gggccgccag gaataagagc agggcaagcc acattacaga taaagcgaag    34500

tcctccccag tgagcattgc caaatgtaag attgaaataa gcatgctggc tagaccctgt    34560

gatatcttcc agataactgg acagaaaatc aggcaagcaa tttttaagaa aatcaacaaa    34620

agaaaagtcg tccaggtgca ggtttagagc ctcaggaaca acgatggaat aagtgcaagg    34680

agtgcgttcc agcatggtta gtgttttttt ggtgatctgt agaacaaaaa ataaacatgc    34740

aatattaaac catgctagcc tggcgaacag gtgggtaaat cactctttcc agcaccaggc    34800

aggctacggg gtctccggcg cgaccctcgt agaagctgtc gccatgattg aaaagcatca    34860

ccgagagacc ttcccggtgg ccggcatgga tgattcgaga agaagcatac actccgggaa    34920

cattggcatc cgtgagtgaa aaaaagcgac ctataaagcc tcggggcact acaatgctca    34980

atctcaattc cagcaaagcc accccatgcg gatggagcac aaaattggca ggtgcgtaaa    35040

aaatgtaatt actcccctcc tgcacaggca gcaaagcccc cgctccctcc agaaacacat    35100

acaaagcctc agcgtccata gcttaccgag cacggcaggc gcaagagtca gagaaaaggc    35160

tgagctctaa cctgactgcc cgctcctgtg ctcaatatat agccctaacc tacactgacg    35220

taaaggccaa agtctaaaaa tacccgccaa aatgacacac acgcccagca cacgcccaga    35280

aaccggtgac acactcaaaa aaatacgtgc gcttcctcaa acgcccaaac cggcgtcatt    35340

tccgggttcc cacgctacgt caccgctcag cgactttcaa attccgtcga ccgttaaaaa    35400

cgtcactcgc cccgccccta acggtcgccc ttctctcggc caatcacctt cctcccttcc    35460

caaattcaaa cgcctcattt gcatattaac gcgcacaaaa agtttgaggt atatatttga    35520

atgatggttt                                                           35530


