                         SEQUENCE LISTING

<110>  Institut dInvestigacions Biomdiques August Pi i Sunyer (IDIBAPS)
       Hospital Clnic de Barcelona
       Universitat de Barcelona
 
<120>  CD19-SPECIFIC CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY

<130>  905984

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  1

Phe Ala Phe Ser Ser Tyr Trp Met Asn Trp Val 
1               5                   10      


<210>  2
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  2

Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5                   10  


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  3

Arg Lys Arg Ile Thr Ala Val Ile Thr 
1               5                   


<210>  4
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  4

Arg Ala Ser Glu Ser Val Asp Asn Phe Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  5
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  5

Ile Tyr Ile Ala Ser Asn Leu Glu Ser 
1               5                   


<210>  6
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  6

His Gln Asn Asn Glu Asp Pro Leu Thr Phe 
1               5                   10  


<210>  7
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  7

Thr Gly Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
1               5                   10                  15      


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp 
            20                  25                  30          


Asn Phe Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln 
        35                  40                  45              


Pro Pro Arg Leu Leu Ile Tyr Ile Ala Ser Asn Leu Glu Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Asn Asn Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  8
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  8

His Ser Gln Ile Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
1               5                   10                  15      


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Ala Phe Ser 
            20                  25                  30          


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Lys Tyr Asn Val 
    50                  55                  60                  


Lys Phe Arg Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Ile Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Lys Arg Ile Thr Ala Val Ile Thr Thr Val Phe Asp 
            100                 105                 110         


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  9
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  9

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  10
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  10

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  11
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  11

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  12
<211>  481
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  12

Thr Gly Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
1               5                   10                  15      


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp 
            20                  25                  30          


Asn Phe Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln 
        35                  40                  45              


Pro Pro Arg Leu Leu Ile Tyr Ile Ala Ser Asn Leu Glu Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys His Gln 
                85                  90                  95      


Asn Asn Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser His Ser Gln Ile Gln Leu Gln Gln Ser Gly Ala 
    130                 135                 140                 


Glu Leu Val Arg Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser 
145                 150                 155                 160 


Gly Phe Ala Phe Ser Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
                165                 170                 175     


Gly Gln Gly Leu Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp 
            180                 185                 190         


Thr Lys Tyr Asn Val Lys Phe Arg Gly Lys Ala Thr Leu Thr Ala Asp 
        195                 200                 205             


Glu Ser Ser Ser Thr Ala Tyr Ile Gln Leu Thr Ser Leu Thr Ser Glu 
    210                 215                 220                 


Asp Ser Gly Val Tyr Phe Cys Ala Arg Lys Arg Ile Thr Ala Val Ile 
225                 230                 235                 240 


Thr Thr Val Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
                245                 250                 255     


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            260                 265                 270         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
        275                 280                 285             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
    290                 295                 300                 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
305                 310                 315                 320 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
                325                 330                 335     


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
            340                 345                 350         


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        355                 360                 365             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    370                 375                 380                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
385                 390                 395                 400 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                405                 410                 415     


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg 
    


<210>  13
<211>  2560
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  13
cgcctttttc cggagggtgg gggagaaccg tatataagtg cagtagtccg tgaacgttct       60

ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt cccgcgggcc      120

tggcctcttt acgggttatg gcccttgcgt gccttgaatt acttccacct ggctgcagta      180

cgtgattctt gatcccgagc ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc      240

ttaaggagcc ccttcgcctc gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg      300

cgtgcgaatc tggtggcacc ttcgcgcctg tctcgctgct ttcgataagt ctctagccat      360

ttaaaatttt tgatgacctg ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc      420

gggccaagat ctgcacactg gtatttcggt ttttggggcc gcgggcggcg acggggcccg      480

tgcgtcccag cgcacatgtt cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg      540

acgggggtag tctcaagctg gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat      600

cgccccgccc tgggcggcaa ggctggcccg gtcggcacca gttgcgtgag cggaaagatg      660

gccgcttccc ggccctgctg cagggagctc aaaatggagg acgcggcgct cgggagagcg      720

ggcgggtgag tcacccacac aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg      780

tgactccact gagtaccggg cgccgtccag gcacctcgat tagttctcgt gcttttggag      840

tacgtcgtct ttaggttggg gggaggggtt ttatgcgatg gagtttcccc acactgagtg      900

ggtggagact gaagttaggc cagcttggca cttgatgtaa ttctccttgg aatttgccct      960

ttttgagttt ggatcttggt tcattctcaa gcctcagaca gtggttcaaa gtttttttct     1020

tccatttcag gtgtcatgag cctcatcccg aatggctctg cctgtcactg gactgctgct     1080

gtcactgggg ctgctgctgc acgccgcaag accaaccggt aacatcgtgc tgactcagag     1140

cccagcatcc ctggccgtct cactgggaca gcgggctacc atcagctgca gagcaagcga     1200

gtccgtggac aacttcggaa attcctttat gcactggtac cagcagaagt ctggccagcc     1260

ccctcgactg ctgatctata ttgcctctaa cctggagagt ggcgtgccag ctaggttctc     1320

tggcagtggg tcacgcacag actttaccct gacaattgat cccgtcgaag ccgacgatgc     1380

cgctacctac tattgccacc agaacaacga ggacccactg actttcggag cagggacaaa     1440

actggaactg aagggtggag gcgggagcgg aggaggcggg tcgggaggag gaggatcggg     1500

tggcggaggc tcacattctc agattcagct gcagcagtca ggggcagagc tggtgcggcc     1560

agggtcctca gtcaagatta gttgtaaggc ttcaggcttt gctttcagct cctactggat     1620

gaactgggtg aaacagcgac caggacaggg actggagtgg atcggacaga tctaccccgg     1680

agacggcgat acaaagtata atgtcaaatt tcggggcaag gccaccctga cagctgacga     1740

gtctagttca accgcctaca tccagctgac ttcactgacc agcgaagatt ccggcgtgta     1800

tttctgcgct cgaaagcgga tcactgcagt cattaccaca gtgtttgacg tgtggggggc     1860

aggaactacc gtgaccgtca gctccacaac tacgccggcg ccgagaccac ctacacctgc     1920

accaactatt gcctctcagc cactgagtct gcgccccgag gcatgtcgac ctgccgctgg     1980

cggggctgtg cacaccaggg gcctagactt cgcctgcgat atctatattt gggctccact     2040

ggcaggaacc tgtggcgtgc tgctgctgtc tctggtcatc acactgtact gcaaaagagg     2100

caggaagaaa ctgctgtata ttttcaagca gccctttatg agacctgtgc agacaactca     2160

ggaggaagac gggtgcagct gtaggttccc tgaggaagag gaaggaggct gtgagctgcg     2220

cgtgaaattt tctcggagtg cagatgcccc agcttaccag cagggccaga accagctgta     2280

taacgagctg aatctggggc ggagagagga atacgacgtg ctggataaga ggcgcgggcg     2340

agatccagaa atgggaggaa aaccccagcg acggaagaac cctcaggagg gactgtacaa     2400

tgaactgcag aaggacaaaa tggcagaggc ctattccgaa atcgggatga aaggagaaag     2460

aaggcgcggc aaggggcatg atggcctgta tcagggactg tcaaccgcaa caaaagatac     2520

ttatgatgct ctgcacatgc aggctctgcc cccgcggtaa                           2560


