                         SEQUENCE LISTING

<110>  Universitaet Zrich
 
<120>  Split Prime Editing Enzyme

<130>  uz464wo

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  1152
<212>  PRT
<213>  Streptococcus pyogenes

<400>  1

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys 
    1145                 1150         


<210>  2
<211>  733
<212>  PRT
<213>  Streptococcus pyogenes

<400>  2

Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met 
1               5                   10                  15      


Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys 
            20                  25                  30          


Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr 
        35                  40                  45              


Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala 
    50                  55                  60                  


Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val 
65                  70                  75                  80  


Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro 
                85                  90                  95      


Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr 
            100                 105                 110         


Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile 
        115                 120                 125             


Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His 
    130                 135                 140                 


Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe 
145                 150                 155                 160 


Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr 
                165                 170                 175     


Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala 
            180                 185                 190         


Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 
        195                 200                 205             


Leu Ser Gln Leu Gly Gly Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
    210                 215                 220                 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
225                 230                 235                 240 


Gly Gly Ser Ser Gly Gly Ser Ser Thr Leu Asn Ile Glu Asp Glu Tyr 
                245                 250                 255     


Arg Leu His Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr 
            260                 265                 270         


Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly 
        275                 280                 285             


Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser 
    290                 295                 300                 


Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu 
305                 310                 315                 320 


Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val 
                325                 330                 335     


Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro 
            340                 345                 350         


Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys 
        355                 360                 365             


Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu 
    370                 375                 380                 


Ser Gly Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys 
385                 390                 395                 400 


Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe 
                405                 410                 415     


Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr 
            420                 425                 430         


Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn 
        435                 440                 445             


Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp 
    450                 455                 460                 


Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser 
465                 470                 475                 480 


Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly 
                485                 490                 495     


Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys 
            500                 505                 510         


Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu 
        515                 520                 525             


Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr 
    530                 535                 540                 


Pro Arg Gln Leu Arg Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu 
545                 550                 555                 560 


Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr 
                565                 570                 575     


Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr 
            580                 585                 590         


Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro 
        595                 600                 605             


Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr 
    610                 615                 620                 


Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val 
625                 630                 635                 640 


Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro 
                645                 650                 655     


Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly 
            660                 665                 670         


Lys Leu Thr Met Gly Gln Pro Leu Val Ile Leu Ala Pro His Ala Val 
        675                 680                 685             


Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg 
    690                 695                 700                 


Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe 
705                 710                 715                 720 


Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro 
                725                 730             


<210>  3
<211>  1916
<212>  PRT
<213>  Streptococcus pyogenes

<400>  3

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        35                  40                  45              


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    50                  55                  60                  


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                85                  90                  95      


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            100                 105                 110         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        115                 120                 125             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    130                 135                 140                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
145                 150                 155                 160 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                165                 170                 175     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            180                 185                 190         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        195                 200                 205             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    210                 215                 220                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
225                 230                 235                 240 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                245                 250                 255     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            260                 265                 270         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        275                 280                 285             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    290                 295                 300                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
305                 310                 315                 320 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                325                 330                 335     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            340                 345                 350         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        355                 360                 365             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    370                 375                 380                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
385                 390                 395                 400 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                405                 410                 415     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr 
        435                 440                 445             


Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
465                 470                 475                 480 


Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe 
                485                 490                 495     


Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg 
            500                 505                 510         


Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys 
        515                 520                 525             


His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
    530                 535                 540                 


Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly 
545                 550                 555                 560 


Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys 
                565                 570                 575     


Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys 
            580                 585                 590         


Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe 
    610                 615                 620                 


Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr 
                645                 650                 655     


Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg 
            660                 665                 670         


Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile 
        675                 680                 685             


Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp 
    690                 695                 700                 


Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu 
705                 710                 715                 720 


Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp 
                725                 730                 735     


Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys 
            740                 745                 750         


Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val 
        755                 760                 765             


Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu 
    770                 775                 780                 


Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys 
785                 790                 795                 800 


Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu 
                805                 810                 815     


His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr 
            820                 825                 830         


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile 
        835                 840                 845             


Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe 
    850                 855                 860                 


Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys 
865                 870                 875                 880 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys 
                885                 890                 895     


Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln 
            900                 905                 910         


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu 
        915                 920                 925             


Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys 
945                 950                 955                 960 


Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu 
                965                 970                 975     


Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys 
            980                 985                 990         


Val Arg Glu Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1025                 1030                 1035             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1040                 1045                 1050             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1055                 1060                 1065             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1070                 1075                 1080             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1085                 1090                 1095             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1100                 1105                 1110             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1115                 1120                 1125             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1130                 1135                 1140             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1145                 1150                 1155             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1160                 1165                 1170             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1175                 1180                 1185             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1190                 1195                 1200             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1205                 1210                 1215             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1220                 1225                 1230             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1235                 1240                 1245             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1250                 1255                 1260             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1265                 1270                 1275             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1280                 1285                 1290             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1295                 1300                 1305             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1310                 1315                 1320             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1325                 1330                 1335             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1340                 1345                 1350             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1355                 1360                 1365             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1370                 1375                 1380             


Gly Gly  Asp Ser Gly Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu 
    1385                 1390                 1395             


Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly 
    1400                 1405                 1410             


Ser Ser  Gly Gly Ser Ser Thr  Leu Asn Ile Glu Asp  Glu Tyr Arg 
    1415                 1420                 1425             


Leu His  Glu Thr Ser Lys Glu  Pro Asp Val Ser Leu  Gly Ser Thr 
    1430                 1435                 1440             


Trp Leu  Ser Asp Phe Pro Gln  Ala Trp Ala Glu Thr  Gly Gly Met 
    1445                 1450                 1455             


Gly Leu  Ala Val Arg Gln Ala  Pro Leu Ile Ile Pro  Leu Lys Ala 
    1460                 1465                 1470             


Thr Ser  Thr Pro Val Ser Ile  Lys Gln Tyr Pro Met  Ser Gln Glu 
    1475                 1480                 1485             


Ala Arg  Leu Gly Ile Lys Pro  His Ile Gln Arg Leu  Leu Asp Gln 
    1490                 1495                 1500             


Gly Ile  Leu Val Pro Cys Gln  Ser Pro Trp Asn Thr  Pro Leu Leu 
    1505                 1510                 1515             


Pro Val  Lys Lys Pro Gly Thr  Asn Asp Tyr Arg Pro  Val Gln Asp 
    1520                 1525                 1530             


Leu Arg  Glu Val Asn Lys Arg  Val Glu Asp Ile His  Pro Thr Val 
    1535                 1540                 1545             


Pro Asn  Pro Tyr Asn Leu Leu  Ser Gly Leu Pro Pro  Ser His Gln 
    1550                 1555                 1560             


Trp Tyr  Thr Val Leu Asp Leu  Lys Asp Ala Phe Phe  Cys Leu Arg 
    1565                 1570                 1575             


Leu His  Pro Thr Ser Gln Pro  Leu Phe Ala Phe Glu  Trp Arg Asp 
    1580                 1585                 1590             


Pro Glu  Met Gly Ile Ser Gly  Gln Leu Thr Trp Thr  Arg Leu Pro 
    1595                 1600                 1605             


Gln Gly  Phe Lys Asn Ser Pro  Thr Leu Phe Asn Glu  Ala Leu His 
    1610                 1615                 1620             


Arg Asp  Leu Ala Asp Phe Arg  Ile Gln His Pro Asp  Leu Ile Leu 
    1625                 1630                 1635             


Leu Gln  Tyr Val Asp Asp Leu  Leu Leu Ala Ala Thr  Ser Glu Leu 
    1640                 1645                 1650             


Asp Cys  Gln Gln Gly Thr Arg  Ala Leu Leu Gln Thr  Leu Gly Asn 
    1655                 1660                 1665             


Leu Gly  Tyr Arg Ala Ser Ala  Lys Lys Ala Gln Ile  Cys Gln Lys 
    1670                 1675                 1680             


Gln Val  Lys Tyr Leu Gly Tyr  Leu Leu Lys Glu Gly  Gln Arg Trp 
    1685                 1690                 1695             


Leu Thr  Glu Ala Arg Lys Glu  Thr Val Met Gly Gln  Pro Thr Pro 
    1700                 1705                 1710             


Lys Thr  Pro Arg Gln Leu Arg  Glu Phe Leu Gly Lys  Ala Gly Phe 
    1715                 1720                 1725             


Cys Arg  Leu Phe Ile Pro Gly  Phe Ala Glu Met Ala  Ala Pro Leu 
    1730                 1735                 1740             


Tyr Pro  Leu Thr Lys Pro Gly  Thr Leu Phe Asn Trp  Gly Pro Asp 
    1745                 1750                 1755             


Gln Gln  Lys Ala Tyr Gln Glu  Ile Lys Gln Ala Leu  Leu Thr Ala 
    1760                 1765                 1770             


Pro Ala  Leu Gly Leu Pro Asp  Leu Thr Lys Pro Phe  Glu Leu Phe 
    1775                 1780                 1785             


Val Asp  Glu Lys Gln Gly Tyr  Ala Lys Gly Val Leu  Thr Gln Lys 
    1790                 1795                 1800             


Leu Gly  Pro Trp Arg Arg Pro  Val Ala Tyr Leu Ser  Lys Lys Leu 
    1805                 1810                 1815             


Asp Pro  Val Ala Ala Gly Trp  Pro Pro Cys Leu Arg  Met Val Ala 
    1820                 1825                 1830             


Ala Ile  Ala Val Leu Thr Lys  Asp Ala Gly Lys Leu  Thr Met Gly 
    1835                 1840                 1845             


Gln Pro  Leu Val Ile Leu Ala  Pro His Ala Val Glu  Ala Leu Val 
    1850                 1855                 1860             


Lys Gln  Pro Pro Asp Arg Trp  Leu Ser Asn Ala Arg  Met Thr His 
    1865                 1870                 1875             


Tyr Gln  Ala Leu Leu Leu Asp  Thr Asp Arg Val Gln  Phe Gly Pro 
    1880                 1885                 1890             


Val Val  Ala Leu Asn Pro Ala  Thr Leu Leu Pro Gly  Ser Glu Phe 
    1895                 1900                 1905             


Glu Pro  Lys Lys Lys Arg Lys  Val 
    1910                 1915     


<210>  4
<211>  815
<212>  PRT
<213>  Streptococcus pyogenes

<400>  4

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn 
            20                  25                  30          


Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn 
        35                  40                  45              


Gly Phe Ile Ala Ser Asn Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Ser Lys Lys Leu Lys Ser Val Lys Glu Leu 
65                  70                  75                  80  


Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile 
                85                  90                  95      


Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile 
            100                 105                 110         


Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys 
        115                 120                 125             


Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala 
    130                 135                 140                 


Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu 
145                 150                 155                 160 


Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val 
                165                 170                 175     


Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu 
            180                 185                 190         


Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu 
        195                 200                 205             


Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu 
    210                 215                 220                 


Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala 
225                 230                 235                 240 


Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr 
                245                 250                 255     


Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu 
            260                 265                 270         


Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Ser Gly Gly 
        275                 280                 285             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    290                 295                 300                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Thr Leu 
305                 310                 315                 320 


Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu Pro Asp 
                325                 330                 335     


Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala 
            340                 345                 350         


Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile 
        355                 360                 365             


Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met 
    370                 375                 380                 


Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu 
385                 390                 395                 400 


Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu 
                405                 410                 415     


Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp 
            420                 425                 430         


Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro 
        435                 440                 445             


Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp Tyr 
    450                 455                 460                 


Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro 
465                 470                 475                 480 


Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly 
                485                 490                 495     


Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
            500                 505                 510         


Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe 
        515                 520                 525             


Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu 
    530                 535                 540                 


Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala 
545                 550                 555                 560 


Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys 
                565                 570                 575     


Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys 
            580                 585                 590         


Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly 
        595                 600                 605             


Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly Lys 
    610                 615                 620                 


Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala 
625                 630                 635                 640 


Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro 
                645                 650                 655     


Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala 
            660                 665                 670         


Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val 
        675                 680                 685             


Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly 
    690                 695                 700                 


Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
705                 710                 715                 720 


Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val 
                725                 730                 735     


Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile 
            740                 745                 750         


Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg 
        755                 760                 765             


Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp 
    770                 775                 780                 


Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr 
785                 790                 795                 800 


Leu Leu Pro Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                805                 810                 815 


<210>  5
<211>  1386
<212>  PRT
<213>  Streptococcus pyogenes

<400>  5

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        35                  40                  45              


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    50                  55                  60                  


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                85                  90                  95      


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            100                 105                 110         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        115                 120                 125             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    130                 135                 140                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
145                 150                 155                 160 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                165                 170                 175     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            180                 185                 190         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        195                 200                 205             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    210                 215                 220                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
225                 230                 235                 240 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                245                 250                 255     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            260                 265                 270         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        275                 280                 285             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    290                 295                 300                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
305                 310                 315                 320 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                325                 330                 335     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            340                 345                 350         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        355                 360                 365             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    370                 375                 380                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
385                 390                 395                 400 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                405                 410                 415     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr 
        435                 440                 445             


Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
465                 470                 475                 480 


Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe 
                485                 490                 495     


Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg 
            500                 505                 510         


Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys 
        515                 520                 525             


His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
    530                 535                 540                 


Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly 
545                 550                 555                 560 


Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys 
                565                 570                 575     


Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys 
            580                 585                 590         


Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe 
    610                 615                 620                 


Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr 
                645                 650                 655     


Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg 
            660                 665                 670         


Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile 
        675                 680                 685             


Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp 
    690                 695                 700                 


Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu 
705                 710                 715                 720 


Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp 
                725                 730                 735     


Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys 
            740                 745                 750         


Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val 
        755                 760                 765             


Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu 
    770                 775                 780                 


Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys 
785                 790                 795                 800 


Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu 
                805                 810                 815     


His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr 
            820                 825                 830         


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile 
        835                 840                 845             


Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe 
    850                 855                 860                 


Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys 
865                 870                 875                 880 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys 
                885                 890                 895     


Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln 
            900                 905                 910         


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu 
        915                 920                 925             


Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys 
945                 950                 955                 960 


Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu 
                965                 970                 975     


Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys 
            980                 985                 990         


Val Arg Glu Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1025                 1030                 1035             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1040                 1045                 1050             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1055                 1060                 1065             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1070                 1075                 1080             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1085                 1090                 1095             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1100                 1105                 1110             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1115                 1120                 1125             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1130                 1135                 1140             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1145                 1150                 1155             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1160                 1165                 1170             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1175                 1180                 1185             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1190                 1195                 1200             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1205                 1210                 1215             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1220                 1225                 1230             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1235                 1240                 1245             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1250                 1255                 1260             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1265                 1270                 1275             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1280                 1285                 1290             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1295                 1300                 1305             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1310                 1315                 1320             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1325                 1330                 1335             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1340                 1345                 1350             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1355                 1360                 1365             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1370                 1375                 1380             


Gly Gly  Asp 
    1385     


<210>  6
<211>  497
<212>  PRT
<213>  Streptococcus pyogenes

<400>  6

Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys 
                485                 490                 495     


Val 
    


<210>  7
<211>  1916
<212>  PRT
<213>  Streptococcus pyogenes

<400>  7

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        35                  40                  45              


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    50                  55                  60                  


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                85                  90                  95      


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            100                 105                 110         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        115                 120                 125             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    130                 135                 140                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
145                 150                 155                 160 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                165                 170                 175     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            180                 185                 190         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        195                 200                 205             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    210                 215                 220                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
225                 230                 235                 240 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                245                 250                 255     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            260                 265                 270         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        275                 280                 285             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    290                 295                 300                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
305                 310                 315                 320 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                325                 330                 335     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            340                 345                 350         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        355                 360                 365             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    370                 375                 380                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
385                 390                 395                 400 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                405                 410                 415     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr 
        435                 440                 445             


Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
465                 470                 475                 480 


Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe 
                485                 490                 495     


Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg 
            500                 505                 510         


Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys 
        515                 520                 525             


His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
    530                 535                 540                 


Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly 
545                 550                 555                 560 


Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys 
                565                 570                 575     


Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys 
            580                 585                 590         


Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe 
    610                 615                 620                 


Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr 
                645                 650                 655     


Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg 
            660                 665                 670         


Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile 
        675                 680                 685             


Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp 
    690                 695                 700                 


Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu 
705                 710                 715                 720 


Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp 
                725                 730                 735     


Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys 
            740                 745                 750         


Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val 
        755                 760                 765             


Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu 
    770                 775                 780                 


Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys 
785                 790                 795                 800 


Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu 
                805                 810                 815     


His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr 
            820                 825                 830         


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile 
        835                 840                 845             


Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe 
    850                 855                 860                 


Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys 
865                 870                 875                 880 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys 
                885                 890                 895     


Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln 
            900                 905                 910         


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu 
        915                 920                 925             


Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys 
945                 950                 955                 960 


Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu 
                965                 970                 975     


Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys 
            980                 985                 990         


Val Arg Glu Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1025                 1030                 1035             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1040                 1045                 1050             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1055                 1060                 1065             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1070                 1075                 1080             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1085                 1090                 1095             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1100                 1105                 1110             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1115                 1120                 1125             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1130                 1135                 1140             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1145                 1150                 1155             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1160                 1165                 1170             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1175                 1180                 1185             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1190                 1195                 1200             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1205                 1210                 1215             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1220                 1225                 1230             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1235                 1240                 1245             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1250                 1255                 1260             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1265                 1270                 1275             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1280                 1285                 1290             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1295                 1300                 1305             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1310                 1315                 1320             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1325                 1330                 1335             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1340                 1345                 1350             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1355                 1360                 1365             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1370                 1375                 1380             


Gly Gly  Asp Ser Gly Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu 
    1385                 1390                 1395             


Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly 
    1400                 1405                 1410             


Ser Ser  Gly Gly Ser Ser Thr  Leu Asn Ile Glu Asp  Glu Tyr Arg 
    1415                 1420                 1425             


Leu His  Glu Thr Ser Lys Glu  Pro Asp Val Ser Leu  Gly Ser Thr 
    1430                 1435                 1440             


Trp Leu  Ser Asp Phe Pro Gln  Ala Trp Ala Glu Thr  Gly Gly Met 
    1445                 1450                 1455             


Gly Leu  Ala Val Arg Gln Ala  Pro Leu Ile Ile Pro  Leu Lys Ala 
    1460                 1465                 1470             


Thr Ser  Thr Pro Val Ser Ile  Lys Gln Tyr Pro Met  Ser Gln Glu 
    1475                 1480                 1485             


Ala Arg  Leu Gly Ile Lys Pro  His Ile Gln Arg Leu  Leu Asp Gln 
    1490                 1495                 1500             


Gly Ile  Leu Val Pro Cys Gln  Ser Pro Trp Asn Thr  Pro Leu Leu 
    1505                 1510                 1515             


Pro Val  Lys Lys Pro Gly Thr  Asn Asp Tyr Arg Pro  Val Gln Asp 
    1520                 1525                 1530             


Leu Arg  Glu Val Asn Lys Arg  Val Glu Asp Ile His  Pro Thr Val 
    1535                 1540                 1545             


Pro Asn  Pro Tyr Asn Leu Leu  Ser Gly Leu Pro Pro  Ser His Gln 
    1550                 1555                 1560             


Trp Tyr  Thr Val Leu Asp Leu  Lys Asp Ala Phe Phe  Cys Leu Arg 
    1565                 1570                 1575             


Leu His  Pro Thr Ser Gln Pro  Leu Phe Ala Phe Glu  Trp Arg Asp 
    1580                 1585                 1590             


Pro Glu  Met Gly Ile Ser Gly  Gln Leu Thr Trp Thr  Arg Leu Pro 
    1595                 1600                 1605             


Gln Gly  Phe Lys Asn Ser Pro  Thr Leu Phe Asn Glu  Ala Leu His 
    1610                 1615                 1620             


Arg Asp  Leu Ala Asp Phe Arg  Ile Gln His Pro Asp  Leu Ile Leu 
    1625                 1630                 1635             


Leu Gln  Tyr Val Asp Asp Leu  Leu Leu Ala Ala Thr  Ser Glu Leu 
    1640                 1645                 1650             


Asp Cys  Gln Gln Gly Thr Arg  Ala Leu Leu Gln Thr  Leu Gly Asn 
    1655                 1660                 1665             


Leu Gly  Tyr Arg Ala Ser Ala  Lys Lys Ala Gln Ile  Cys Gln Lys 
    1670                 1675                 1680             


Gln Val  Lys Tyr Leu Gly Tyr  Leu Leu Lys Glu Gly  Gln Arg Trp 
    1685                 1690                 1695             


Leu Thr  Glu Ala Arg Lys Glu  Thr Val Met Gly Gln  Pro Thr Pro 
    1700                 1705                 1710             


Lys Thr  Pro Arg Gln Leu Arg  Glu Phe Leu Gly Lys  Ala Gly Phe 
    1715                 1720                 1725             


Cys Arg  Leu Phe Ile Pro Gly  Phe Ala Glu Met Ala  Ala Pro Leu 
    1730                 1735                 1740             


Tyr Pro  Leu Thr Lys Pro Gly  Thr Leu Phe Asn Trp  Gly Pro Asp 
    1745                 1750                 1755             


Gln Gln  Lys Ala Tyr Gln Glu  Ile Lys Gln Ala Leu  Leu Thr Ala 
    1760                 1765                 1770             


Pro Ala  Leu Gly Leu Pro Asp  Leu Thr Lys Pro Phe  Glu Leu Phe 
    1775                 1780                 1785             


Val Asp  Glu Lys Gln Gly Tyr  Ala Lys Gly Val Leu  Thr Gln Lys 
    1790                 1795                 1800             


Leu Gly  Pro Trp Arg Arg Pro  Val Ala Tyr Leu Ser  Lys Lys Leu 
    1805                 1810                 1815             


Asp Pro  Val Ala Ala Gly Trp  Pro Pro Cys Leu Arg  Met Val Ala 
    1820                 1825                 1830             


Ala Ile  Ala Val Leu Thr Lys  Asp Ala Gly Lys Leu  Thr Met Gly 
    1835                 1840                 1845             


Gln Pro  Leu Val Ile Leu Ala  Pro His Ala Val Glu  Ala Leu Val 
    1850                 1855                 1860             


Lys Gln  Pro Pro Asp Arg Trp  Leu Ser Asn Ala Arg  Met Thr His 
    1865                 1870                 1875             


Tyr Gln  Ala Leu Leu Leu Asp  Thr Asp Arg Val Gln  Phe Gly Pro 
    1880                 1885                 1890             


Val Val  Ala Leu Asn Pro Ala  Thr Leu Leu Pro Gly  Ser Glu Phe 
    1895                 1900                 1905             


Glu Pro  Lys Lys Lys Arg Lys  Val 
    1910                 1915     


<210>  8
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  structural part of pegRNA

<400>  8
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgc                                                       76


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  guide RNA sequence trac

<400>  9
cctaatgtac tgtgtgcagt                                                   20


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  template sequence tract

<400>  10
gccttccgag tctcccact                                                    19


<210>  11
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hybridizing sequence tract

<400>  11
gcacacagta cat                                                          13


<210>  12
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  12
ggctttcggc cccgtttctt gggaatggcc                                        30


<210>  13
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  13
ggctttcggc ccgtttcttg ggaatggcct                                        30


<210>  14
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  14
ctgatgtcgg catctgtttt gtgagacata                                        30


<210>  15
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  15
ctgatgtcgg catgtgtttt gtgagacata                                        30


<210>  16
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  16
caacaccctc atcatgacca ctcgaggtg                                         29


<210>  17
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  17
caacaccctc atcaggacca ctcgaggtg                                         29


<210>  18
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  18
caaatggcaa agaaagataa taaatgtttt                                        30


<210>  19
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  19
caaatggcaa aagaaagata ataaatgttt                                        30


<210>  20
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  20
gcagacttct cctcaggagt cagatgcacc                                        30


<210>  21
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  21
gcagacttct ccacaggagt cagatgcacc                                        30


<210>  22
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  22
tcccaggggt actttcattg aattccgaaa                                        30


<210>  23
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  23
tcccaggggt actttaattg aattccgaaa                                        30


<210>  24
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  24
acagcggaaa ccctggaaaa gcagctttcg                                        30


<210>  25
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  25
acagcggaaa ccccggaaaa gcagctttcg                                        30


<210>  26
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  26
gacttctccc tacagtgggg ggactgcacc                                        30


<210>  27
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  27
gacttctccc tacactgggg ggactgcacc                                        30


<210>  28
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  28
gcgctgggca tccgcctagt gagctgggaa                                        30


<210>  29
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  29
gcgctgggca tccgcatagt gagctgggaa                                        30


<210>  30
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  30
taaagaaaat atcatctttg gtgtttccta t                                      31


<210>  31
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  31
taaagaaaat atcattggtg tttcctat                                          28


<210>  32
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  32
atttagaaaa aacttggatc cctatgaaca                                        30


<210>  33
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  33
atttagaaaa aagttggatc cctatgaaca                                        30


<210>  34
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  34
aagatcagct gcagggccca tagccggatg                                        30


<210>  35
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  35
aagatcagct gcaggcccat agccggatgt                                        30


<210>  36
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  36
acactggtga ttactatgac ctgtatggag                                        30


<210>  37
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  37
acactggtga tgactatgac ctgtatggag                                        30


<210>  38
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  38
caggcggctc ccactgtact gtgcaggagt                                        30


<210>  39
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  39
caggcggctc ccacctgtac tgtgcaggag                                        30


<210>  40
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  40
ggagtacact ggaaaggatg cttgatgtaa                                        30


<210>  41
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  41
ggagtacact ggaagggatg cttgatgtaa                                        30


<210>  42
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  42
cctgcgggag aagaaagcgg gctcagcagg                                        30


<210>  43
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  43
cctgcgggag aagcaagcgg gctcagcagg                                        30


<210>  44
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  44
tcctcagcac agcacgccac ttcccaaagt                                        30


<210>  45
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  45
tcctcagcac aggacgccac ttcccaaagt                                        30


<210>  46
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  46
tgtatgggtc gtagcgaact gagaagggcc                                        30


<210>  47
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  47
tgtatgggtc gcagcgaact gagaagggcc                                        30


<210>  48
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  48
agacgatcct ggggggtgtg aacaaacact c                                      31


<210>  49
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  49
agacgatcct gggggtgtga acaaacactc                                        30


<210>  50
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  50
cttgagtcac catgagtagt agtttaggaa                                        30


<210>  51
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  51
cttgagtcac catgggtagt agtttaggaa                                        30


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  3x

<400>  52

Gly Gly Gly Gly Ser 
1               5   


<210>  53
<211>  42
<212>  DNA
<213>  Mus musculus

<400>  53
actcgggctg gagcttgttc gcgctggcat tcttgcaggt tg                          42


<210>  54
<211>  42
<212>  DNA
<213>  Mus musculus

<400>  54
actcgggctg gagcttgttc gcgctgccat tcttgcaggt tg                          42


<210>  55
<211>  40
<212>  DNA
<213>  Mus musculus

<400>  55
actcgggctg gagcttgttc gctgccattc ttgcaggttg                             40


<210>  56
<211>  41
<212>  DNA
<213>  Mus musculus

<400>  56
actcgggctg agcttgttcg cgctgccatt cttgcaggtt g                           41


<210>  57
<211>  78
<212>  DNA
<213>  Mus musculus

<400>  57
tcgtctcgag atttcttggg tggcctggcc ttccgagtct cccactgcac acagtacatt       60

aggcatggat ctaagccc                                                     78


<210>  58
<211>  26
<212>  PRT
<213>  Mus musculus

<400>  58

Ser Ser Arg Asp Phe Leu Gly Gly Leu Ala Phe Arg Val Ser His Cys 
1               5                   10                  15      


Thr Gln Tyr Ile Arg His Gly Ser Lys Pro 
            20                  25      


<210>  59
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nicking RNA


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Spacer

<400>  59
cttgggtggc ctggccttcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugc                                 96


<210>  60
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  60

Gly Gly Leu Ala Phe Arg Val Ser His Cys Thr Gln 
1               5                   10          


<210>  61
<211>  78
<212>  DNA
<213>  Mus musculus

<400>  61
tcgtctcgag atttcttggg tggcctggcc ttccgagtct cccactgcac acagtacatt       60

aggcatggat ctaagccc                                                     78


<210>  62
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pegRNA


<220>
<221>  misc_feature
<222>  (106)..(123)
<223>  Spacer

<400>  62
gcacacagua cauuuccggg ucuuccacuc guggcugagc cacggugaaa aaguucaacu       60

auugccugau cggaauaaaa uugaacgaua aagaucgaga uuuugtacgt gtgcatgtaa      120

tcc                                                                    123


<210>  63
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  63
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tcccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  64
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  64
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgggtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  65
<211>  83
<212>  DNA
<213>  Mus musculus

<400>  65
ctggcttact gtcgtctcga gatttcttgg gtttccgggt cttccactgc acacagtaca       60

ttaggcatgg atctaagccc atg                                               83


<210>  66
<211>  77
<212>  DNA
<213>  Mus musculus

<400>  66
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccacagt acattaggca       60

tggatctaag cccatgt                                                      77


<210>  67
<211>  87
<212>  DNA
<213>  Mus musculus

<400>  67
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgggtc tgcacacagt       60

acattaggca tggatctaag cccatgt                                           87


<210>  68
<211>  89
<212>  DNA
<213>  Mus musculus

<400>  68
ctggcttact gtcgtctcga gatttcttgg gtggcccttc cgggtcttcc actgcacaca       60

gtacattagg catggatcta agcccatgt                                         89


<210>  69
<211>  83
<212>  DNA
<213>  Mus musculus

<400>  69
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgggca cacagtacat       60

taggcatgga tctaagccca tgt                                               83


<210>  70
<211>  88
<212>  DNA
<213>  Mus musculus

<400>  70
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgggtc ttccacacag       60

tacattaggc atggatctaa gcccatgt                                          88


<210>  71
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  71
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tcccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  72
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  72
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgggtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  73
<211>  76
<212>  DNA
<213>  Mus musculus

<400>  73
ctggcttact gtcgtctcga gatcttccgg gtcttccact gcacacagta cattaggcat       60

ggatctaagc ccatgt                                                       76


<210>  74
<211>  59
<212>  DNA
<213>  Mus musculus

<400>  74
ctggcttact gtcgtctcga gatgcacaca gtacattagg catggatcta agcccatgt        59


<210>  75
<211>  85
<212>  DNA
<213>  Mus musculus

<400>  75
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccggctg cacacagtac       60

attaggcatg gatctaagcc catgt                                             85


<210>  76
<211>  88
<212>  DNA
<213>  Mus musculus

<400>  76
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgggtc ttccacacag       60

tacattaggc atggatctaa gcccatgt                                          88


<210>  77
<211>  80
<212>  DNA
<213>  Mus musculus

<400>  77
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cactgcacac agtacattag       60

gcatggatct aagcccatgt                                                   80


<210>  78
<211>  91
<212>  DNA
<213>  Mus musculus

<400>  78
ctggcttact gtcgtctcga gatttcttgg gtggcctgct tccgggtctt ccactgcaca       60

cagtacatta ggcatggatc taagcccatg t                                      91


<210>  79
<211>  89
<212>  DNA
<213>  Mus musculus

<400>  79
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttcccttcc actgcacaca       60

gtacattagg catggatcta agcccatgt                                         89


<210>  80
<211>  89
<212>  DNA
<213>  Mus musculus

<400>  80
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgggtc ttcccacaca       60

gtacattagg catggatcta agcccatgt                                         89


<210>  81
<211>  89
<212>  DNA
<213>  Mus musculus

<400>  81
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgggtc ttcgcacaca       60

gtacattagg catggatcta agcccatgt                                         89


<210>  82
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  82
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tcccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  83
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  83
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  84
<211>  92
<212>  DNA
<213>  Mus musculus

<400>  84
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tccactgcac       60

acagtacatt aggcatggat ctaagcccat gt                                     92


<210>  85
<211>  92
<212>  DNA
<213>  Mus musculus

<400>  85
ctggcttact gtcgtctcga gatttcttgg gtggcctgcc ttccgagtct tccactgcac       60

acagtacatt aggcatggat ctaagcccat gt                                     92


<210>  86
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  86
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tcccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  87
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  87
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  88
<211>  92
<212>  DNA
<213>  Mus musculus

<400>  88
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc ttccctgcac       60

acagtacatt aggcatggat ctaagcccat gt                                     92


<210>  89
<211>  92
<212>  DNA
<213>  Mus musculus

<400>  89
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tccactgcac       60

acagtacatt aggcatggat ctaagcccat gt                                     92


<210>  90
<211>  92
<212>  DNA
<213>  Mus musculus

<400>  90
ctggcttact gtcgtctcga gatttcttgg gtggcctgcc ttccgagtct tccactgcac       60

acagtacatt aggcatggat ctaagcccat gt                                     92


<210>  91
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  91
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tcccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  92
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  92
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  93
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  93
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgggtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  94
<211>  92
<212>  DNA
<213>  Mus musculus

<400>  94
ctggcttact gtcgtctcga gatttcttgg gtgcctggcc ttccgagtct tccactgcac       60

acagtacatt aggcatggat ctaagcccat gt                                     92


<210>  95
<211>  91
<212>  DNA
<213>  Mus musculus

<400>  95
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttgagtctt ccactgcaca       60

cagtacatta ggcatggatc taagcccatg t                                      91


<210>  96
<211>  92
<212>  DNA
<213>  Mus musculus

<400>  96
ctggcttact gtcgtctcga gatttcttgg gtggcctggc ctccgagtct tccactgcac       60

acagtacatt aggcatggat ctaagcccat gt                                     92


<210>  97
<211>  92
<212>  DNA
<213>  Mus musculus

<400>  97
ctggcttact gtcgtctcga gatttcttgg gtggccggcc ttccgagtct tccactgcac       60

acagtacatt aggcatggat ctaagcccat gt                                     92


<210>  98
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  98
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tcccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  99
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  99
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  100
<211>  59
<212>  DNA
<213>  Mus musculus

<400>  100
ctggcttact gtcgtctcga gatttcttgg gtacattagg catggatcta agcccatgt        59


<210>  101
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  101
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tcccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  102
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  102
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgggtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  103
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  103
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  104
<211>  91
<212>  DNA
<213>  Mus musculus

<400>  104
ctggcttact gtcgtctcga gatttcttgg gtggcctggc tccgagtctt ccactgcaca       60

cagtacatta ggcatggatc taagcccatg t                                      91


<210>  105
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  105
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tcccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  106
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  106
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  107
<211>  90
<212>  DNA
<213>  Mus musculus

<400>  107
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc ttccgcacac       60

agtacattag gcatggatct aagcccatgt                                        90


<210>  108
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  108
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc tcccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  109
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  109
ctggcttact gtcgtctcga gatttcttgg gtggcctggc cttccgagtc ttccactgca       60

cacagtacat taggcatgga tctaagccca tgt                                    93


<210>  110
<211>  92
<212>  DNA
<213>  Mus musculus

<400>  110
ctggcttact gtcgtctcga gatttcttgg gtggcctgcc ttccgagtct cccactgcac       60

acagtacatt aggcatggat ctaagcccat gt                                     92


<210>  111
<211>  858
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion polypeptide

<400>  111

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        35                  40                  45              


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    50                  55                  60                  


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                85                  90                  95      


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            100                 105                 110         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        115                 120                 125             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    130                 135                 140                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
145                 150                 155                 160 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                165                 170                 175     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            180                 185                 190         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        195                 200                 205             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    210                 215                 220                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
225                 230                 235                 240 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                245                 250                 255     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            260                 265                 270         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        275                 280                 285             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    290                 295                 300                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
305                 310                 315                 320 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                325                 330                 335     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            340                 345                 350         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        355                 360                 365             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    370                 375                 380                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
385                 390                 395                 400 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                405                 410                 415     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr 
        435                 440                 445             


Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
465                 470                 475                 480 


Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe 
                485                 490                 495     


Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg 
            500                 505                 510         


Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys 
        515                 520                 525             


His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
    530                 535                 540                 


Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly 
545                 550                 555                 560 


Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys 
                565                 570                 575     


Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys 
            580                 585                 590         


Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe 
    610                 615                 620                 


Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr 
                645                 650                 655     


Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg 
            660                 665                 670         


Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile 
        675                 680                 685             


Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp 
    690                 695                 700                 


Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu 
705                 710                 715                 720 


Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Gly Gly Gly Gly Ser 
                725                 730                 735     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Leu Ser Tyr Glu Thr 
            740                 745                 750         


Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val 
        755                 760                 765             


Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn 
    770                 775                 780                 


Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu 
785                 790                 795                 800 


Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys 
                805                 810                 815     


Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu 
            820                 825                 830         


Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 
        835                 840                 845             


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
    850                 855             


<210>  112
<211>  1455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion polypeptide

<400>  112

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln 
            20                  25                  30          


Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys 
        35                  40                  45              


Asn Gly Phe Ile Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Gly Gly Gly Gly Ser Ser Gly Gln Gly Asp Ser Leu His Glu His Ile 
65                  70                  75                  80  


Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr 
                85                  90                  95      


Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro 
            100                 105                 110         


Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys 
        115                 120                 125             


Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile 
    130                 135                 140                 


Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr 
145                 150                 155                 160 


Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg 
                165                 170                 175     


Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr 
            180                 185                 190         


Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile 
        195                 200                 205             


Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp 
    210                 215                 220                 


Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg 
225                 230                 235                 240 


Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu 
                245                 250                 255     


Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe 
            260                 265                 270         


Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala 
        275                 280                 285             


Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys 
    290                 295                 300                 


Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser 
305                 310                 315                 320 


Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn 
                325                 330                 335     


Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala 
            340                 345                 350         


Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp 
        355                 360                 365             


Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln Glu 
    370                 375                 380                 


Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn 
385                 390                 395                 400 


Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg 
                405                 410                 415     


Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys 
            420                 425                 430         


Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val 
        435                 440                 445             


Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu 
    450                 455                 460                 


Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys 
465                 470                 475                 480 


Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala 
                485                 490                 495     


Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys 
            500                 505                 510         


Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser 
        515                 520                 525             


Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys 
    530                 535                 540                 


Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe 
545                 550                 555                 560 


Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu 
                565                 570                 575     


Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu 
            580                 585                 590         


Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn 
        595                 600                 605             


Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu 
    610                 615                 620                 


Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp 
625                 630                 635                 640 


Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys 
                645                 650                 655     


Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr 
            660                 665                 670         


Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp 
        675                 680                 685             


Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile 
    690                 695                 700                 


His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln 
705                 710                 715                 720 


Leu Gly Gly Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
                725                 730                 735     


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
            740                 745                 750         


Ser Gly Gly Ser Ser Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His 
        755                 760                 765             


Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser 
    770                 775                 780                 


Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val 
785                 790                 795                 800 


Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val 
                805                 810                 815     


Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys 
            820                 825                 830         


Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln 
        835                 840                 845             


Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn 
    850                 855                 860                 


Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu 
865                 870                 875                 880 


Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu 
                885                 890                 895     


Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe 
            900                 905                 910         


Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu 
        915                 920                 925             


Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg 
    930                 935                 940                 


Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu 
945                 950                 955                 960 


His Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu 
                965                 970                 975     


Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp 
            980                 985                 990         


Cys Gln Gln Gly Thr Arg Ala Leu  Leu Gln Thr Leu Gly  Asn Leu Gly 
        995                 1000                 1005             


Tyr Arg  Ala Ser Ala Lys Lys  Ala Gln Ile Cys Gln  Lys Gln Val 
    1010                 1015                 1020             


Lys Tyr  Leu Gly Tyr Leu Leu  Lys Glu Gly Gln Arg  Trp Leu Thr 
    1025                 1030                 1035             


Glu Ala  Arg Lys Glu Thr Val  Met Gly Gln Pro Thr  Pro Lys Thr 
    1040                 1045                 1050             


Pro Arg  Gln Leu Arg Glu Phe  Leu Gly Lys Ala Gly  Phe Cys Arg 
    1055                 1060                 1065             


Leu Phe  Ile Pro Gly Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro 
    1070                 1075                 1080             


Leu Thr  Lys Pro Gly Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln 
    1085                 1090                 1095             


Lys Ala  Tyr Gln Glu Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala 
    1100                 1105                 1110             


Leu Gly  Leu Pro Asp Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp 
    1115                 1120                 1125             


Glu Lys  Gln Gly Tyr Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly 
    1130                 1135                 1140             


Pro Trp  Arg Arg Pro Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro 
    1145                 1150                 1155             


Val Ala  Ala Gly Trp Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile 
    1160                 1165                 1170             


Ala Val  Leu Thr Lys Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro 
    1175                 1180                 1185             


Leu Val  Ile Leu Ala Pro His  Ala Val Glu Ala Leu  Val Lys Gln 
    1190                 1195                 1200             


Pro Pro  Asp Arg Trp Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln 
    1205                 1210                 1215             


Ala Leu  Leu Leu Asp Thr Asp  Arg Val Gln Phe Gly  Pro Val Val 
    1220                 1225                 1230             


Ala Leu  Asn Pro Ala Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu 
    1235                 1240                 1245             


Gln His  Asn Cys Leu Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg 
    1250                 1255                 1260             


Pro Asp  Leu Thr Asp Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp 
    1265                 1270                 1275             


Tyr Thr  Asp Gly Ser Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala 
    1280                 1285                 1290             


Gly Ala  Ala Val Thr Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala 
    1295                 1300                 1305             


Leu Pro  Ala Gly Thr Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu 
    1310                 1315                 1320             


Thr Gln  Ala Leu Lys Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr 
    1325                 1330                 1335             


Thr Asp  Ser Arg Tyr Ala Phe  Ala Thr Ala His Ile  His Gly Glu 
    1340                 1345                 1350             


Ile Tyr  Arg Arg Arg Gly Trp  Leu Thr Ser Glu Gly  Lys Glu Ile 
    1355                 1360                 1365             


Lys Asn  Lys Asp Glu Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu 
    1370                 1375                 1380             


Pro Lys  Arg Leu Ser Ile Ile  His Cys Pro Gly His  Gln Lys Gly 
    1385                 1390                 1395             


His Ser  Ala Glu Ala Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala 
    1400                 1405                 1410             


Arg Lys  Ala Ala Ile Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu 
    1415                 1420                 1425             


Ile Glu  Asn Ser Ser Pro Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1430                 1435                 1440             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1445                 1450                 1455 


