                         SEQUENCE LISTING

<110>  Hoba Therapeutics ApS
 
<120>  Prevention and treatment of chemotherapy-induced neuropathic pain

<130>  P5897PC00

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1109
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (118)..(999)

<400>  1
gcttcgccgg ggccgggcgg ccggcgcccc cggctgctcc cgccgccgcc cggacccgcg       60

ccccgccggg gcagcggtgg tgagagcccc gactccccgg acgccgcccg ccgtgcc         117

atg ggg ttc ccg gcc gcg gcg ctg ctc tgc gcg ctg tgc tgc ggc ctc        165
Met Gly Phe Pro Ala Ala Ala Leu Leu Cys Ala Leu Cys Cys Gly Leu           
1               5                   10                  15                

ctg gcc ccg gct gcc cgc gcc ggc tac tcc gag gag cgc tgc agc tgg        213
Leu Ala Pro Ala Ala Arg Ala Gly Tyr Ser Glu Glu Arg Cys Ser Trp           
            20                  25                  30                    

agg ggc agc ggc ctc acc cag gag ccc ggc agc gtg ggg cag ctg gcc        261
Arg Gly Ser Gly Leu Thr Gln Glu Pro Gly Ser Val Gly Gln Leu Ala           
        35                  40                  45                        

ctg gcc tgt gcg gag ggc gcg gtt gag tgg ctg tac ccg gct ggg gcg        309
Leu Ala Cys Ala Glu Gly Ala Val Glu Trp Leu Tyr Pro Ala Gly Ala           
    50                  55                  60                            

ctg cgc ctg acc ctg ggc ggc ccc gat ccc aga gcg cgg ccc ggc atc        357
Leu Arg Leu Thr Leu Gly Gly Pro Asp Pro Arg Ala Arg Pro Gly Ile           
65                  70                  75                  80            

gcc tgt ctg cgg ccg gtg cgg ccc ttc gcg ggc gcc cag gtc ttc gcg        405
Ala Cys Leu Arg Pro Val Arg Pro Phe Ala Gly Ala Gln Val Phe Ala           
                85                  90                  95                

gag cgc gca ggg ggc gcc ctg gag ctg ctg ctg gcc gag ggc ccg ggc        453
Glu Arg Ala Gly Gly Ala Leu Glu Leu Leu Leu Ala Glu Gly Pro Gly           
            100                 105                 110                   

ccg gca ggg ggc cgc tgc gtg cgc tgg ggt ccc cgc gag cgc cgg gcc        501
Pro Ala Gly Gly Arg Cys Val Arg Trp Gly Pro Arg Glu Arg Arg Ala           
        115                 120                 125                       

ctc ttc ctg cag gcc acg ccg cac cag gac atc agc cgc cgc gtg gcc        549
Leu Phe Leu Gln Ala Thr Pro His Gln Asp Ile Ser Arg Arg Val Ala           
    130                 135                 140                           

gcc ttc cgc ttt gag ctg cgc gag gac ggg cgc ccc gag ctg ccc ccg        597
Ala Phe Arg Phe Glu Leu Arg Glu Asp Gly Arg Pro Glu Leu Pro Pro           
145                 150                 155                 160           

cag gcc cac ggt ctc ggc gta gac ggt gcc tgc agg ccc tgc agc gac        645
Gln Ala His Gly Leu Gly Val Asp Gly Ala Cys Arg Pro Cys Ser Asp           
                165                 170                 175               

gct gag ctg ctc ctg gcc gca tgc acc agc gac ttc gta att cac ggg        693
Ala Glu Leu Leu Leu Ala Ala Cys Thr Ser Asp Phe Val Ile His Gly           
            180                 185                 190                   

atc atc cat ggg gtc acc cat gac gtg gag ctg cag gag tct gtc atc        741
Ile Ile His Gly Val Thr His Asp Val Glu Leu Gln Glu Ser Val Ile           
        195                 200                 205                       

act gtg gtg gcc gcc cgt gtc ctc cgc cag aca ccg ccg ctg ttc cag        789
Thr Val Val Ala Ala Arg Val Leu Arg Gln Thr Pro Pro Leu Phe Gln           
    210                 215                 220                           

gcg ggg cga tcc ggg gac cag ggg ctg acc tcc att cgt acc cca ctg        837
Ala Gly Arg Ser Gly Asp Gln Gly Leu Thr Ser Ile Arg Thr Pro Leu           
225                 230                 235                 240           

cgc tgt ggc gtc cac ccg ggc cca ggc acc ttc ctc ttc atg ggc tgg        885
Arg Cys Gly Val His Pro Gly Pro Gly Thr Phe Leu Phe Met Gly Trp           
                245                 250                 255               

agc cgc ttt ggg gag gcc cgg ctg ggc tgt gcc cca cga ttc cag gag        933
Ser Arg Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg Phe Gln Glu           
            260                 265                 270                   

ttc cgc cgt gcc tac gag gct gcc cgt gct gcc cac ctc cac ccc tgc        981
Phe Arg Arg Ala Tyr Glu Ala Ala Arg Ala Ala His Leu His Pro Cys           
        275                 280                 285                       

gag gtg gcg ctg cac tga ggggctgggt gctggggagg ggctggtagg              1029
Glu Val Ala Leu His                                                       
    290                                                                   

agggagggtg ggcccactgc tttggaggtg atgggactat caataagaac tctgttcacg     1089

caaaaaaaaa aaaaaaaaaa                                                 1109


<210>  2
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Phe Pro Ala Ala Ala Leu Leu Cys Ala Leu Cys Cys Gly Leu 
1               5                   10                  15      


Leu Ala Pro Ala Ala Arg Ala Gly Tyr Ser Glu Glu Arg Cys Ser Trp 
            20                  25                  30          


Arg Gly Ser Gly Leu Thr Gln Glu Pro Gly Ser Val Gly Gln Leu Ala 
        35                  40                  45              


Leu Ala Cys Ala Glu Gly Ala Val Glu Trp Leu Tyr Pro Ala Gly Ala 
    50                  55                  60                  


Leu Arg Leu Thr Leu Gly Gly Pro Asp Pro Arg Ala Arg Pro Gly Ile 
65                  70                  75                  80  


Ala Cys Leu Arg Pro Val Arg Pro Phe Ala Gly Ala Gln Val Phe Ala 
                85                  90                  95      


Glu Arg Ala Gly Gly Ala Leu Glu Leu Leu Leu Ala Glu Gly Pro Gly 
            100                 105                 110         


Pro Ala Gly Gly Arg Cys Val Arg Trp Gly Pro Arg Glu Arg Arg Ala 
        115                 120                 125             


Leu Phe Leu Gln Ala Thr Pro His Gln Asp Ile Ser Arg Arg Val Ala 
    130                 135                 140                 


Ala Phe Arg Phe Glu Leu Arg Glu Asp Gly Arg Pro Glu Leu Pro Pro 
145                 150                 155                 160 


Gln Ala His Gly Leu Gly Val Asp Gly Ala Cys Arg Pro Cys Ser Asp 
                165                 170                 175     


Ala Glu Leu Leu Leu Ala Ala Cys Thr Ser Asp Phe Val Ile His Gly 
            180                 185                 190         


Ile Ile His Gly Val Thr His Asp Val Glu Leu Gln Glu Ser Val Ile 
        195                 200                 205             


Thr Val Val Ala Ala Arg Val Leu Arg Gln Thr Pro Pro Leu Phe Gln 
    210                 215                 220                 


Ala Gly Arg Ser Gly Asp Gln Gly Leu Thr Ser Ile Arg Thr Pro Leu 
225                 230                 235                 240 


Arg Cys Gly Val His Pro Gly Pro Gly Thr Phe Leu Phe Met Gly Trp 
                245                 250                 255     


Ser Arg Phe Gly Glu Ala Arg Leu Gly Cys Ala Pro Arg Phe Gln Glu 
            260                 265                 270         


Phe Arg Arg Ala Tyr Glu Ala Ala Arg Ala Ala His Leu His Pro Cys 
        275                 280                 285             


Glu Val Ala Leu His 
    290             


<210>  3
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Tyr Ser Glu Glu Arg Cys Ser Trp Arg Gly Ser Gly Leu Thr Gln 
1               5                   10                  15      


Glu Pro Gly Ser Val Gly Gln Leu Ala Leu Ala Cys Ala Glu Gly Ala 
            20                  25                  30          


Val Glu Trp Leu Tyr Pro Ala Gly Ala Leu Arg Leu Thr Leu Gly Gly 
        35                  40                  45              


Pro Asp Pro Arg Ala Arg Pro Gly Ile Ala Cys Leu Arg Pro Val Arg 
    50                  55                  60                  


Pro Phe Ala Gly Ala Gln Val Phe Ala Glu Arg Ala Gly Gly Ala Leu 
65                  70                  75                  80  


Glu Leu Leu Leu Ala Glu Gly Pro Gly Pro Ala Gly Gly Arg Cys Val 
                85                  90                  95      


Arg Trp Gly Pro Arg Glu Arg Arg Ala Leu Phe Leu Gln Ala Thr Pro 
            100                 105                 110         


His Gln Asp Ile Ser Arg Arg Val Ala Ala Phe Arg Phe Glu Leu Arg 
        115                 120                 125             


Glu Asp Gly Arg Pro Glu Leu Pro Pro Gln Ala His Gly Leu Gly Val 
    130                 135                 140                 


Asp Gly Ala Cys Arg Pro Cys Ser Asp Ala Glu Leu Leu Leu Ala Ala 
145                 150                 155                 160 


Cys Thr Ser Asp Phe Val Ile His Gly Ile Ile His Gly Val Thr His 
                165                 170                 175     


Asp Val Glu Leu Gln Glu Ser Val Ile Thr Val Val Ala Ala Arg Val 
            180                 185                 190         


Leu Arg Gln Thr Pro Pro Leu Phe Gln Ala Gly Arg Ser Gly Asp Gln 
        195                 200                 205             


Gly Leu Thr Ser Ile Arg Thr Pro Leu Arg Cys Gly Val His Pro Gly 
    210                 215                 220                 


Pro Gly Thr Phe Leu Phe Met Gly Trp Ser Arg Phe Gly Glu Ala Arg 
225                 230                 235                 240 


Leu Gly Cys Ala Pro Arg Phe Gln Glu Phe Arg Arg Ala Tyr Glu Ala 
                245                 250                 255     


Ala Arg Ala Ala His Leu His Pro Cys Glu Val Ala Leu His 
            260                 265                 270 


<210>  4
<211>  1363
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (84)..(959)

<400>  4
gggcagccgc gccgcgggct gctcgcgctg cggccccgac cctcccgggg cagcagtccg       60

aggccccggc gcgtccccta acc atg ctg gta gcc acg ctt ctt tgc gcg ctc      113
                          Met Leu Val Ala Thr Leu Leu Cys Ala Leu         
                          1               5                   10          

tgt tgc ggc ctc ctg gcc gcg tcc gct cac gct ggc tac tcg gaa gac        161
Cys Cys Gly Leu Leu Ala Ala Ser Ala His Ala Gly Tyr Ser Glu Asp           
                15                  20                  25                

cgc tgc agc tgg agg ggc agc ggt ttg acc cag gag cct ggc agc gtg        209
Arg Cys Ser Trp Arg Gly Ser Gly Leu Thr Gln Glu Pro Gly Ser Val           
            30                  35                  40                    

ggg cag ctg acc ctg gac tgt act gag ggc gct atc gag tgg ctg tac        257
Gly Gln Leu Thr Leu Asp Cys Thr Glu Gly Ala Ile Glu Trp Leu Tyr           
        45                  50                  55                        

cca gct ggg gcg ctg cgc ctg acc ctg ggc ggc ccc gat ccg ggc aca        305
Pro Ala Gly Ala Leu Arg Leu Thr Leu Gly Gly Pro Asp Pro Gly Thr           
    60                  65                  70                            

cgg ccc agc atc gtc tgt ctg cgc cca gag cgg ccc ttc gct ggt gcc        353
Arg Pro Ser Ile Val Cys Leu Arg Pro Glu Arg Pro Phe Ala Gly Ala           
75                  80                  85                  90            

cag gtc ttc gct gaa cgt atg acc ggc aat cta gag ttg cta ctg gcc        401
Gln Val Phe Ala Glu Arg Met Thr Gly Asn Leu Glu Leu Leu Leu Ala           
                95                  100                 105               

gag ggc ccg gac ctg gct ggg ggc cgc tgc atg cgc tgg ggt ccc cgc        449
Glu Gly Pro Asp Leu Ala Gly Gly Arg Cys Met Arg Trp Gly Pro Arg           
            110                 115                 120                   

gag cgc cga gcc ctt ttc ctg cag gcc aca cca cac cgc gac atc agc        497
Glu Arg Arg Ala Leu Phe Leu Gln Ala Thr Pro His Arg Asp Ile Ser           
        125                 130                 135                       

cgc aga gtt gct gcc ttc cgt ttt gaa ctg cac gag gac caa cgt gca        545
Arg Arg Val Ala Ala Phe Arg Phe Glu Leu His Glu Asp Gln Arg Ala           
    140                 145                 150                           

gaa atg tct ccc cag gct caa ggt ctt ggt gtg gat ggt gcc tgc agg        593
Glu Met Ser Pro Gln Ala Gln Gly Leu Gly Val Asp Gly Ala Cys Arg           
155                 160                 165                 170           

ccc tgc agt gat gcc gag ctc ctc ctg gct gca tgc acc agt gat ttt        641
Pro Cys Ser Asp Ala Glu Leu Leu Leu Ala Ala Cys Thr Ser Asp Phe           
                175                 180                 185               

gtg atc cac ggg acc atc cat ggg gtc gcc cat gac aca gag ctg caa        689
Val Ile His Gly Thr Ile His Gly Val Ala His Asp Thr Glu Leu Gln           
            190                 195                 200                   

gaa tca gtc atc act gtg gtg gtt gct cgt gtc atc cgc cag aca ctg        737
Glu Ser Val Ile Thr Val Val Val Ala Arg Val Ile Arg Gln Thr Leu           
        205                 210                 215                       

cca ctg ttc aag gaa ggg agc tcg gag ggc caa ggc cgg gcc tcc att        785
Pro Leu Phe Lys Glu Gly Ser Ser Glu Gly Gln Gly Arg Ala Ser Ile           
    220                 225                 230                           

cgt acc ttg ctg cgc tgt ggt gtg cgt cct ggc cca ggc tcc ttc ctc        833
Arg Thr Leu Leu Arg Cys Gly Val Arg Pro Gly Pro Gly Ser Phe Leu           
235                 240                 245                 250           

ttc atg ggc tgg agc cga ttt ggc gaa gct tgg ctg ggc tgt gct ccc        881
Phe Met Gly Trp Ser Arg Phe Gly Glu Ala Trp Leu Gly Cys Ala Pro           
                255                 260                 265               

cgc ttc caa gag ttc agc cgt gtc tat tca gct gct ctc acg acc cat        929
Arg Phe Gln Glu Phe Ser Arg Val Tyr Ser Ala Ala Leu Thr Thr His           
            270                 275                 280                   

ctc aac cca tgt gag atg gca ctg gac tga gagacctggg agcaagccct          979
Leu Asn Pro Cys Glu Met Ala Leu Asp                                       
        285                 290                                           

ggatggacct tcttctggag atggggtgtt ggggagggtg atgggagggt gggtgagaag     1039

ggtgtggctc ggatggcatc ctggtaccca cagtgagctg gtagaatact aagtaatctg     1099

gaccatacca gccactgtag tcatggtctt ctgtggcagg cagcataccc agctctgtgc     1159

ctgcctcact ttgtctactc tccagtctgc tgcccttcta acccttctta gcctgctgac     1219

cagtgagctc atgttttcct cgaattccag ggtgctgctg gggttcagag caaccgtgcc     1279

gtagtttgga agacttgagc taattgtttt ttttttgttt gtttttttgt ttgtttaaag     1339

gtggcctggg gggggcggca aaca                                            1363


<210>  5
<211>  291
<212>  PRT
<213>  Mus musculus

<400>  5

Met Leu Val Ala Thr Leu Leu Cys Ala Leu Cys Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ala Ser Ala His Ala Gly Tyr Ser Glu Asp Arg Cys Ser Trp Arg Gly 
            20                  25                  30          


Ser Gly Leu Thr Gln Glu Pro Gly Ser Val Gly Gln Leu Thr Leu Asp 
        35                  40                  45              


Cys Thr Glu Gly Ala Ile Glu Trp Leu Tyr Pro Ala Gly Ala Leu Arg 
    50                  55                  60                  


Leu Thr Leu Gly Gly Pro Asp Pro Gly Thr Arg Pro Ser Ile Val Cys 
65                  70                  75                  80  


Leu Arg Pro Glu Arg Pro Phe Ala Gly Ala Gln Val Phe Ala Glu Arg 
                85                  90                  95      


Met Thr Gly Asn Leu Glu Leu Leu Leu Ala Glu Gly Pro Asp Leu Ala 
            100                 105                 110         


Gly Gly Arg Cys Met Arg Trp Gly Pro Arg Glu Arg Arg Ala Leu Phe 
        115                 120                 125             


Leu Gln Ala Thr Pro His Arg Asp Ile Ser Arg Arg Val Ala Ala Phe 
    130                 135                 140                 


Arg Phe Glu Leu His Glu Asp Gln Arg Ala Glu Met Ser Pro Gln Ala 
145                 150                 155                 160 


Gln Gly Leu Gly Val Asp Gly Ala Cys Arg Pro Cys Ser Asp Ala Glu 
                165                 170                 175     


Leu Leu Leu Ala Ala Cys Thr Ser Asp Phe Val Ile His Gly Thr Ile 
            180                 185                 190         


His Gly Val Ala His Asp Thr Glu Leu Gln Glu Ser Val Ile Thr Val 
        195                 200                 205             


Val Val Ala Arg Val Ile Arg Gln Thr Leu Pro Leu Phe Lys Glu Gly 
    210                 215                 220                 


Ser Ser Glu Gly Gln Gly Arg Ala Ser Ile Arg Thr Leu Leu Arg Cys 
225                 230                 235                 240 


Gly Val Arg Pro Gly Pro Gly Ser Phe Leu Phe Met Gly Trp Ser Arg 
                245                 250                 255     


Phe Gly Glu Ala Trp Leu Gly Cys Ala Pro Arg Phe Gln Glu Phe Ser 
            260                 265                 270         


Arg Val Tyr Ser Ala Ala Leu Thr Thr His Leu Asn Pro Cys Glu Met 
        275                 280                 285             


Ala Leu Asp 
    290     


<210>  6
<211>  270
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Tyr Ser Glu Asp Arg Cys Ser Trp Arg Gly Ser Gly Leu Thr Gln 
1               5                   10                  15      


Glu Pro Gly Ser Val Gly Gln Leu Thr Leu Asp Cys Thr Glu Gly Ala 
            20                  25                  30          


Ile Glu Trp Leu Tyr Pro Ala Gly Ala Leu Arg Leu Thr Leu Gly Gly 
        35                  40                  45              


Pro Asp Pro Gly Thr Arg Pro Ser Ile Val Cys Leu Arg Pro Glu Arg 
    50                  55                  60                  


Pro Phe Ala Gly Ala Gln Val Phe Ala Glu Arg Met Thr Gly Asn Leu 
65                  70                  75                  80  


Glu Leu Leu Leu Ala Glu Gly Pro Asp Leu Ala Gly Gly Arg Cys Met 
                85                  90                  95      


Arg Trp Gly Pro Arg Glu Arg Arg Ala Leu Phe Leu Gln Ala Thr Pro 
            100                 105                 110         


His Arg Asp Ile Ser Arg Arg Val Ala Ala Phe Arg Phe Glu Leu His 
        115                 120                 125             


Glu Asp Gln Arg Ala Glu Met Ser Pro Gln Ala Gln Gly Leu Gly Val 
    130                 135                 140                 


Asp Gly Ala Cys Arg Pro Cys Ser Asp Ala Glu Leu Leu Leu Ala Ala 
145                 150                 155                 160 


Cys Thr Ser Asp Phe Val Ile His Gly Thr Ile His Gly Val Ala His 
                165                 170                 175     


Asp Thr Glu Leu Gln Glu Ser Val Ile Thr Val Val Val Ala Arg Val 
            180                 185                 190         


Ile Arg Gln Thr Leu Pro Leu Phe Lys Glu Gly Ser Ser Glu Gly Gln 
        195                 200                 205             


Gly Arg Ala Ser Ile Arg Thr Leu Leu Arg Cys Gly Val Arg Pro Gly 
    210                 215                 220                 


Pro Gly Ser Phe Leu Phe Met Gly Trp Ser Arg Phe Gly Glu Ala Trp 
225                 230                 235                 240 


Leu Gly Cys Ala Pro Arg Phe Gln Glu Phe Ser Arg Val Tyr Ser Ala 
                245                 250                 255     


Ala Leu Thr Thr His Leu Asn Pro Cys Glu Met Ala Leu Asp 
            260                 265                 270 


<210>  7
<211>  1026
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (1)..(876)

<400>  7
atg ctg gta gcg gcg ctt ctc tgc gcg ctg tgc tgc ggc ctc ttg gct         48
Met Leu Val Ala Ala Leu Leu Cys Ala Leu Cys Cys Gly Leu Leu Ala           
1               5                   10                  15                

gcg tcc gct cga gct ggc tac tcc gag gac cgc tgc agc tgg agg ggc         96
Ala Ser Ala Arg Ala Gly Tyr Ser Glu Asp Arg Cys Ser Trp Arg Gly           
            20                  25                  30                    

agc ggt ttg acc cag gaa cct ggc agc gtg ggg cag ctg acc ctg gat        144
Ser Gly Leu Thr Gln Glu Pro Gly Ser Val Gly Gln Leu Thr Leu Asp           
        35                  40                  45                        

tgt act gag ggt gct atc gag tgg ctg tat cca gct ggg gcg ctg cgc        192
Cys Thr Glu Gly Ala Ile Glu Trp Leu Tyr Pro Ala Gly Ala Leu Arg           
    50                  55                  60                            

ctg act cta ggc ggc tct gat ccg ggc acg cgg ccc agc atc gtc tgt        240
Leu Thr Leu Gly Gly Ser Asp Pro Gly Thr Arg Pro Ser Ile Val Cys           
65                  70                  75                  80            

ctg cgc cca aca cgg ccc ttc gct ggt gcc cag gtc ttc gct gaa cgg        288
Leu Arg Pro Thr Arg Pro Phe Ala Gly Ala Gln Val Phe Ala Glu Arg           
                85                  90                  95                

atg gcc ggc aac cta gag ttg cta ctg gcc gag ggc caa ggc ctg gct        336
Met Ala Gly Asn Leu Glu Leu Leu Leu Ala Glu Gly Gln Gly Leu Ala           
            100                 105                 110                   

ggg ggc cgc tgc atg cgc tgg ggt cct cgc gag cgc cga gcc ctt ttc        384
Gly Gly Arg Cys Met Arg Trp Gly Pro Arg Glu Arg Arg Ala Leu Phe           
        115                 120                 125                       

ctg cag gcc acg cca cac cgg gac atc agc cgc aga gtt gct gcc ttc        432
Leu Gln Ala Thr Pro His Arg Asp Ile Ser Arg Arg Val Ala Ala Phe           
    130                 135                 140                           

caa ttt gaa ctg cac gag gac caa cgt gca gaa atg tct ccc cag gcc        480
Gln Phe Glu Leu His Glu Asp Gln Arg Ala Glu Met Ser Pro Gln Ala           
145                 150                 155                 160           

caa ggt ttt ggt gtg gat ggt gcc tgc agg ccc tgc agt gat gcc gag        528
Gln Gly Phe Gly Val Asp Gly Ala Cys Arg Pro Cys Ser Asp Ala Glu           
                165                 170                 175               

ctc ctt ctg act gca tgc acc agt gac ttt gtg atc cat ggg acc atc        576
Leu Leu Leu Thr Ala Cys Thr Ser Asp Phe Val Ile His Gly Thr Ile           
            180                 185                 190                   

cat ggg gtc gtc cat gac atg gag ctg caa gaa tca gtc atc act gtg        624
His Gly Val Val His Asp Met Glu Leu Gln Glu Ser Val Ile Thr Val           
        195                 200                 205                       

gtg gcc act cgt gtc atc cgc cag aca ctg cca ctg ttc cag gaa ggg        672
Val Ala Thr Arg Val Ile Arg Gln Thr Leu Pro Leu Phe Gln Glu Gly           
    210                 215                 220                           

agc tcg gag ggc cgg ggc cag gcc tcc gtt cgt acc ttg ttg cgc tgt        720
Ser Ser Glu Gly Arg Gly Gln Ala Ser Val Arg Thr Leu Leu Arg Cys           
225                 230                 235                 240           

ggt gtg cgt cct ggc cca ggc tcc ttc ctc ttc atg ggc tgg agc cga        768
Gly Val Arg Pro Gly Pro Gly Ser Phe Leu Phe Met Gly Trp Ser Arg           
                245                 250                 255               

ttt ggc gaa gct tgg ctg ggc tgc gct ccc cgc ttc caa gag ttc agc        816
Phe Gly Glu Ala Trp Leu Gly Cys Ala Pro Arg Phe Gln Glu Phe Ser           
            260                 265                 270                   

cgt gtc tat tca gct gct ctc gcg gcc cac ctc aac cca tgt gag gtg        864
Arg Val Tyr Ser Ala Ala Leu Ala Ala His Leu Asn Pro Cys Glu Val           
        275                 280                 285                       

gca ctg gac tga gagacctggg agcaagccct ggatggatct tcctctgggg            916
Ala Leu Asp                                                               
    290                                                                   

atggggtgtt ggggaggggt gataggaggg tgggtgggaa gggtgtggct cagatggcat      976

cctggtaccc acagtgaggt ggtagaatac taaataacct ggatcacacc                1026


<210>  8
<211>  291
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Leu Val Ala Ala Leu Leu Cys Ala Leu Cys Cys Gly Leu Leu Ala 
1               5                   10                  15      


Ala Ser Ala Arg Ala Gly Tyr Ser Glu Asp Arg Cys Ser Trp Arg Gly 
            20                  25                  30          


Ser Gly Leu Thr Gln Glu Pro Gly Ser Val Gly Gln Leu Thr Leu Asp 
        35                  40                  45              


Cys Thr Glu Gly Ala Ile Glu Trp Leu Tyr Pro Ala Gly Ala Leu Arg 
    50                  55                  60                  


Leu Thr Leu Gly Gly Ser Asp Pro Gly Thr Arg Pro Ser Ile Val Cys 
65                  70                  75                  80  


Leu Arg Pro Thr Arg Pro Phe Ala Gly Ala Gln Val Phe Ala Glu Arg 
                85                  90                  95      


Met Ala Gly Asn Leu Glu Leu Leu Leu Ala Glu Gly Gln Gly Leu Ala 
            100                 105                 110         


Gly Gly Arg Cys Met Arg Trp Gly Pro Arg Glu Arg Arg Ala Leu Phe 
        115                 120                 125             


Leu Gln Ala Thr Pro His Arg Asp Ile Ser Arg Arg Val Ala Ala Phe 
    130                 135                 140                 


Gln Phe Glu Leu His Glu Asp Gln Arg Ala Glu Met Ser Pro Gln Ala 
145                 150                 155                 160 


Gln Gly Phe Gly Val Asp Gly Ala Cys Arg Pro Cys Ser Asp Ala Glu 
                165                 170                 175     


Leu Leu Leu Thr Ala Cys Thr Ser Asp Phe Val Ile His Gly Thr Ile 
            180                 185                 190         


His Gly Val Val His Asp Met Glu Leu Gln Glu Ser Val Ile Thr Val 
        195                 200                 205             


Val Ala Thr Arg Val Ile Arg Gln Thr Leu Pro Leu Phe Gln Glu Gly 
    210                 215                 220                 


Ser Ser Glu Gly Arg Gly Gln Ala Ser Val Arg Thr Leu Leu Arg Cys 
225                 230                 235                 240 


Gly Val Arg Pro Gly Pro Gly Ser Phe Leu Phe Met Gly Trp Ser Arg 
                245                 250                 255     


Phe Gly Glu Ala Trp Leu Gly Cys Ala Pro Arg Phe Gln Glu Phe Ser 
            260                 265                 270         


Arg Val Tyr Ser Ala Ala Leu Ala Ala His Leu Asn Pro Cys Glu Val 
        275                 280                 285             


Ala Leu Asp 
    290     


<210>  9
<211>  270
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Gly Tyr Ser Glu Asp Arg Cys Ser Trp Arg Gly Ser Gly Leu Thr Gln 
1               5                   10                  15      


Glu Pro Gly Ser Val Gly Gln Leu Thr Leu Asp Cys Thr Glu Gly Ala 
            20                  25                  30          


Ile Glu Trp Leu Tyr Pro Ala Gly Ala Leu Arg Leu Thr Leu Gly Gly 
        35                  40                  45              


Ser Asp Pro Gly Thr Arg Pro Ser Ile Val Cys Leu Arg Pro Thr Arg 
    50                  55                  60                  


Pro Phe Ala Gly Ala Gln Val Phe Ala Glu Arg Met Ala Gly Asn Leu 
65                  70                  75                  80  


Glu Leu Leu Leu Ala Glu Gly Gln Gly Leu Ala Gly Gly Arg Cys Met 
                85                  90                  95      


Arg Trp Gly Pro Arg Glu Arg Arg Ala Leu Phe Leu Gln Ala Thr Pro 
            100                 105                 110         


His Arg Asp Ile Ser Arg Arg Val Ala Ala Phe Gln Phe Glu Leu His 
        115                 120                 125             


Glu Asp Gln Arg Ala Glu Met Ser Pro Gln Ala Gln Gly Phe Gly Val 
    130                 135                 140                 


Asp Gly Ala Cys Arg Pro Cys Ser Asp Ala Glu Leu Leu Leu Thr Ala 
145                 150                 155                 160 


Cys Thr Ser Asp Phe Val Ile His Gly Thr Ile His Gly Val Val His 
                165                 170                 175     


Asp Met Glu Leu Gln Glu Ser Val Ile Thr Val Val Ala Thr Arg Val 
            180                 185                 190         


Ile Arg Gln Thr Leu Pro Leu Phe Gln Glu Gly Ser Ser Glu Gly Arg 
        195                 200                 205             


Gly Gln Ala Ser Val Arg Thr Leu Leu Arg Cys Gly Val Arg Pro Gly 
    210                 215                 220                 


Pro Gly Ser Phe Leu Phe Met Gly Trp Ser Arg Phe Gly Glu Ala Trp 
225                 230                 235                 240 


Leu Gly Cys Ala Pro Arg Phe Gln Glu Phe Ser Arg Val Tyr Ser Ala 
                245                 250                 255     


Ala Leu Ala Ala His Leu Asn Pro Cys Glu Val Ala Leu Asp 
            260                 265                 270 


<210>  10
<211>  882
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimised

<400>  10
atgggctttc ccgctgccgc cctgctgtgc gctctgtgct gcggactgct ggctcctgca       60

gccagagccg gctacagcga ggaacggtgc agctggcggg gcagcggcct gacccaggaa      120

cctggcagcg tcggccagct cgcactggcc tgtgcagaag gcgccgtgga gtggctgtac      180

cccgcaggcg ccctgagact gaccctgggc ggacccgacc ccagagccag acccggcatt      240

gcctgtctga ggcccgtgcg gcctttcgct ggcgcccagg tgttcgccga gagagccggc      300

ggagccctgg aactcctgct cgccgaaggc cctggtccag ccggcggaag atgcgtgaga      360

tggggcccaa gagagcggag agccctgttc ctgcaagcca ccccccacca ggacatcagc      420

agacgggtgg ccgccttcag attcgagctg cgggaggacg gtagacccga gctgccacct      480

caggcccacg gactgggagt ggacggcgcc tgcagaccct gtagcgacgc cgagctgctg      540

ctcgccgcct gcaccagcga cttcgtgatc cacggcatca tccacggcgt gacccacgac      600

gtggagctgc aggaaagcgt catcaccgtc gtcgccgcca gagtgctgag acagaccccc      660

cctctgttcc aggccggcag aagcggcgac cagggcctga ccagcatccg gacccccctg      720

agatgcggcg tgcatcccgg acccggcacc ttcctgttca tgggctggtc cagattcggc      780

gaggcccggc tgggctgcgc tccccggttc caggaattca gacgggccta cgaggccgcc      840

agggccgctc atctgcaccc ctgcgaggtg gccctgcatt ga                         882


<210>  11
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Consensus sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (76)..(77)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (88)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (133)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (135)..(136)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (142)..(142)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (159)..(159)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (170)..(170)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (175)..(175)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (178)..(178)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (189)..(190)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (193)..(193)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (197)..(197)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (201)..(202)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (204)..(204)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (206)..(208)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (210)..(211)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (216)..(216)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (222)..(222)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (227)..(227)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (251)..(251)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (253)..(253)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (255)..(255)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (258)..(260)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (263)..(263)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (267)..(267)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (270)..(270)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Gly Tyr Ser Glu Xaa Arg Cys Ser Trp Arg Gly Ser Gly Leu Thr Gln 
1               5                   10                  15      


Glu Pro Gly Ser Val Gly Gln Leu Xaa Leu Xaa Cys Xaa Glu Gly Ala 
            20                  25                  30          


Xaa Glu Trp Leu Tyr Pro Ala Gly Ala Leu Arg Leu Thr Leu Gly Gly 
        35                  40                  45              


Xaa Asp Pro Xaa Xaa Arg Pro Xaa Ile Xaa Cys Leu Arg Pro Xaa Arg 
    50                  55                  60                  


Pro Phe Ala Gly Ala Gln Val Phe Ala Glu Arg Xaa Xaa Gly Xaa Leu 
65                  70                  75                  80  


Glu Leu Leu Leu Ala Glu Gly Xaa Xaa Xaa Ala Gly Gly Arg Cys Xaa 
                85                  90                  95      


Arg Trp Gly Pro Arg Glu Arg Arg Ala Leu Phe Leu Gln Ala Thr Pro 
            100                 105                 110         


His Xaa Asp Ile Ser Arg Arg Val Ala Ala Phe Xaa Phe Glu Leu Xaa 
        115                 120                 125             


Glu Asp Xaa Arg Xaa Glu Xaa Xaa Pro Gln Ala Xaa Gly Xaa Gly Val 
    130                 135                 140                 


Asp Gly Ala Cys Arg Pro Cys Ser Asp Ala Glu Leu Leu Leu Xaa Ala 
145                 150                 155                 160 


Cys Thr Ser Asp Phe Val Ile His Gly Xaa Ile His Gly Val Xaa His 
                165                 170                 175     


Asp Xaa Glu Leu Gln Glu Ser Val Ile Thr Val Val Xaa Xaa Arg Val 
            180                 185                 190         


Xaa Arg Gln Thr Xaa Pro Leu Phe Xaa Xaa Gly Xaa Ser Xaa Xaa Xaa 
        195                 200                 205             


Gly Xaa Xaa Ser Xaa Arg Thr Xaa Leu Arg Cys Gly Val Xaa Pro Gly 
    210                 215                 220                 


Pro Gly Xaa Phe Leu Phe Met Gly Trp Ser Arg Phe Gly Glu Ala Xaa 
225                 230                 235                 240 


Leu Gly Cys Ala Pro Arg Phe Gln Glu Phe Xaa Arg Xaa Tyr Xaa Ala 
                245                 250                 255     


Ala Xaa Xaa Xaa His Leu Xaa Pro Cys Glu Xaa Ala Leu Xaa 
            260                 265                 270 


