                         SEQUENCE LISTING

<110>  Immatics Biotechnologies GmbH
 
<120>  Improved BMA031 antigen binding polypeptides

<130>  1017-43 PCT

<150>  EP21172352.3
<151>  2021-05-05

<150>  US 63/184,698
<151>  2021-05-05

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of BMA031 (V36)

<400>  1

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of BMA031 (V36)

<400>  2

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  3
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH1 of BMA031 (V36) including His tag

<400>  3

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Gly Ser Gly His His His His His His 
            100                 105                 110         


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human kappa light chain constant domain

<400>  4

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  5
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab heavy chain BMA031 (V36)

<400>  5

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly 
    210                 215                 220                 


Ser Gly His His His His His His 
225                 230         


<210>  6
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab light chain BMA031 (V36)

<400>  6

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_H90Y

<400>  7

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL_S31R_S56R

<400>  8

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Arg Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Arg Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_T30N_S31R

<400>  9

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Asn Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_T30S_S31R_Y53R_E100aD

<400>  10

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Ser Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_S31R

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  12
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_T30S_Y53R

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  13
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL_S31N_S56R_S93N

<400>  13

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Arg Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asn Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_N54K_H90Y

<400>  14

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Lys Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_T30N_S31N_Y53R

<400>  15

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Asn Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_T30N_S31R_V56I

<400>  16

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Asn Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Ile Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_S31R_N54K_E100aD

<400>  17

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Lys Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL_S56R

<400>  18

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Arg Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_T30R

<400>  19

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Arg Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_T30K

<400>  20

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Lys Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  21
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_S31K

<400>  21

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Lys Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_Y53R

<400>  22

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_Y53K

<400>  23

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  24
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_N54R

<400>  24

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Arg Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  25
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_N54K

<400>  25

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Lys Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  26
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL_S31R

<400>  26

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Arg Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  27
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL_S31K

<400>  27

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Lys Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  28
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL_S56K

<400>  28

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Lys Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  29
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_Y53H

<400>  29

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro His Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_S31H

<400>  30

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr His Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  31
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_S31R_H90Y

<400>  31

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_Y53R_H90Y

<400>  32

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_N54R_H90Y

<400>  33

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Arg Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_E61Q_H90Y

<400>  34

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  35
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCER chain 2 VH_S31R

<400>  35

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Arg Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  36
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCER chain 2 VH_Y53R_H90Y

<400>  36

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  37
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCER Chain 2 VH_wt

<400>  37

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  38
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCER chain 2 VH_Y53R

<400>  38

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  39
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCER chain 1 VL_wt

<400>  39

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  40
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv BMA031(V36)

<400>  40

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  41
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-A01

<400>  41

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Arg Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Arg Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  42
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-C03

<400>  42

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Asn Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  43
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-F02

<400>  43

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Ser Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  44
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-A02

<400>  44

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  45
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-D01

<400>  45

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Ser Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  46
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-D02

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Asn Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Arg Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Asn Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  47
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-B01

<400>  47

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Lys Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  48
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-D03

<400>  48

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Asn Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  49
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-E01

<400>  49

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Asn Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Ile Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  50
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-C01

<400>  50

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Lys Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  51
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-YU561-C02

<400>  51

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Glu Gly Gly Gly 
        115                 120                 125             


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Gln Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Thr Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala 
            180                 185                 190         


Arg Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCR1 Kabat

<400>  52

Ser Tyr Val Met His 
1               5   


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Kabat


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is A or N

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is E or Q

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is Q or K

<400>  53

Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Xaa Xaa Lys Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  54

Ser Ala Thr Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR2

<400>  55

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 Kabat


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)

<400>  56

Gly Ser Tyr Tyr Asp Tyr Xaa Gly Phe Val Tyr 
1               5                   10      


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 Kabat


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is S or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is selected from the group consisting of Q, D, 
       H, S, Y, A and N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is P or A

<400>  57

Gln Gln Trp Ser Xaa Xaa Xaa Leu Thr 
1               5                   


<210>  58
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH humanized BMA031 Shearman

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  59
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL humanized BMA031 Shearman

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ile Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  60
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC BMA031 (V36): huIgG1 (constant domains allotype G1m17,1)

<400>  60

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  61
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIgG1 (G1m17,1) CH1 and CH2 including hinge

<400>  61

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 Chothia

<400>  62

Gly Tyr Lys Phe Thr Ser Tyr 
1               5           


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2 Chothia

<400>  63

Asn Pro Tyr Asn Asp Val 
1               5       


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3 Kabat

<400>  64

Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr 
1               5                   10      


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 Kabat


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is an amino acid selected from the group 
       consisting of Q, D, H, S, Y, A and N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is P or A

<400>  65

Gln Gln Trp Ser Ser Xaa Xaa Leu Thr 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 Kabat


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is S or N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is P or A

<400>  66

Gln Gln Trp Ser Xaa Asn Xaa Leu Thr 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3 Kabat


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is S or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6  is an amino acid selected from the group 
       consisting of Q, D, H, S, Y, A and N

<400>  67

Gln Gln Trp Ser Xaa Xaa Pro Leu Thr 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  68

Gln Gln Trp Ser Ser Gln Pro Leu Thr 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  69

Gln Gln Trp Ser Ser Asp Pro Leu Thr 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  70

Gln Gln Trp Ser Ser His Pro Leu Thr 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  71

Gln Gln Trp Ser Ser Ser Pro Leu Thr 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  72

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  73

Gln Gln Trp Ser Ser Ala Pro Leu Thr 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  74

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  75

Gln Gln Trp Ser Ser Gln Ala Leu Thr 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  76

Gln Gln Trp Ser Ser Asp Ala Leu Thr 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  77

Gln Gln Trp Ser Ser His Ala Leu Thr 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  78

Gln Gln Trp Ser Ser Ser Ala Leu Thr 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  79

Gln Gln Trp Ser Ser Tyr Ala Leu Thr 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  80

Gln Gln Trp Ser Ser Ala Ala Leu Thr 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  81

Gln Gln Trp Ser Ser Asn Ala Leu Thr 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  82

Gln Gln Trp Ser Asn Gln Pro Leu Thr 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  83

Gln Gln Trp Asn Ser Asp Pro Leu Thr 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  84

Gln Gln Trp Asn Ser His Pro Leu Thr 
1               5                   


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QQWNSSPLT

<400>  85

Gln Gln Trp Asn Ser Ser Pro Leu Thr 
1               5                   


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  86

Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  87

Gln Gln Trp Asn Ser Ala Pro Leu Thr 
1               5                   


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  88

Gln Gln Trp Asn Ser Asn Pro Leu Thr 
1               5                   


<210>  89
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  89

Gln Gln Trp Ser Asn Gln Ala Leu Thr 
1               5                   


<210>  90
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  90

Gln Gln Trp Asn Ser Asp Ala Leu Thr 
1               5                   


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  91

Gln Gln Trp Asn Ser His Ala Leu Thr 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  92

Gln Gln Trp Asn Ser Ser Ala Leu Thr 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  93

Gln Gln Trp Asn Ser Tyr Ala Leu Thr 
1               5                   


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  94

Gln Gln Trp Asn Ser Ala Ala Leu Thr 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  95

Gln Gln Trp Asn Ser Asn Ala Leu Thr 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is S or N

<400>  96

Gln Gln Trp Ser Xaa Asn Pro Leu Thr 
1               5                   


<210>  97
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL1_BM_VH28_HV

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  98
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL1_BM_VH31_HV

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  99
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEBE1_H10_HV

<400>  99

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  100
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEBE1_H66_HV

<400>  100

Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  101
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEBE1_H71_HV

<400>  101

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Ala Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  102
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL1BMVK43_VL

<400>  102

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  103
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR1

<400>  103

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr 
            20                  25                  30  


<210>  104
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR2

<400>  104

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  105
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR3

<400>  105

Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys Ala Arg 
            20                  25                  30          


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFR4

<400>  106

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  107
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR1

<400>  107

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR2

<400>  108

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
1               5                   10                  15  


<210>  109
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR3

<400>  109

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LFR4

<400>  110

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  111
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc hole mutant

<400>  111

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro 
225                 


<210>  112
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc knob mutant

<400>  112

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro 
225                 


