                         SEQUENCE LISTING

<110>  Immatics biotechnologies GmbH
 
<120>  Antigen binding proteins specifically binding PRAME

<130>  1017-29 PCT

<150>  EP21172351.5
<151>  2021-05-05

<150>  US63/184,689
<151>  2021-05-05

<160>  384   

<170>  PatentIn version 3.5

<210>  1
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  1

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala 
            20                  25                  30          


Leu His Trp Tyr Arg Trp Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe 
        35                  40                  45              


Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn Ile 
            100                 105                 110         


Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser 
        115                 120                 125             


Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val 
    130                 135                 140                 


Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu 
145                 150                 155                 160 


Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser 
                165                 170                 175     


Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile 
            180                 185                 190         


Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys 
        195                 200                 205             


Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn 
    210                 215                 220                 


Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
225                 230                 235                 240 


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250     


<210>  2
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  2

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn 
        35                  40                  45              


Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ser 
                85                  90                  95      


Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
            100                 105                 110         


Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
        115                 120                 125             


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
    130                 135                 140                 


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
145                 150                 155                 160 


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
                165                 170                 175     


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
    210                 215                 220                 


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
        275                 280                 285             


Arg Gly 
    290 


<210>  3
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  3

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala 
            20                  25                  30          


Leu His Trp Tyr Arg Trp Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe 
        35                  40                  45              


Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro 
            100                 105                 110 


<210>  4
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  4

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn 
        35                  40                  45              


Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ser 
                85                  90                  95      


Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  5
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  5

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala 
            20                  25                  30          


Leu His Trp Tyr Arg Trp Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe 
        35                  40                  45              


Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Glu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  6
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  6

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Asn 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Met Thr Ser Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Asn Asn Asn Glu Pro Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  7

Ser Ser Asn Phe Tyr Ala 
1               5       


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  8

Met Thr Leu Asn Gly Asp Glu 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  9

Ala Leu Tyr Asn Asn Asn Asp Met Arg 
1               5                   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  10

Ser Gly His Asn Ser 
1               5   


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  11

Phe Asn Asn Asn Val Pro 
1               5       


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  12

Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr 
1               5                   10      


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  13

Ser Ser Asn Phe Tyr Asn 
1               5       


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  14

Met Thr Ser Asn Gly Asp Glu 
1               5           


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  15

Phe Asn Asn Asn Glu Pro 
1               5       


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  16

Val Lys Glu Phe Gln Asp 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  17

Asn Lys Glu Phe Gln Asp 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  18

Thr Arg Glu Phe Gln Asp 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  19

Asn Arg Glu Phe Gln Asp 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  20

Thr Ser Glu Phe Gln Asp 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  21

Thr Lys Glu Phe Gln Asp 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  22

Val Arg Glu Phe Gln Asp 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  23

Thr Ala Glu Phe Gln Asp 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  24

Val Ser Glu Phe Gln Asp 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  25

Val Ala Glu Phe Gln Asp 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  26

Ile Lys Glu Phe Gln Asn 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  27

Val Arg Glu Phe Gln Asn 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  28

Thr Ala Glu Phe Gln Asn 
1               5       


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  29

Phe Gly Pro Tyr Gly Val Glu 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  30

Phe Gly Pro Tyr Gly Arg Glu 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  31

Phe Gly Pro Tyr Gly Thr Glu 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  32

Phe Gly Pro Tyr Gly Lys Glu 
1               5           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  33

Ala Leu Tyr Asn Asn Leu Asp Met Arg 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  34

Ala Leu Tyr Asn Asn Tyr Asp Met Arg 
1               5                   


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  35

Tyr Gln Asn Thr Ala Ile 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  36

Phe Gln Asn Thr Ala Val 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  37

Tyr Gln Asn Thr Ala Val 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  38

Tyr Gln Asn Thr Ala Leu 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  39

Phe Gln Asn Thr Ala Thr 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  40

Met Gln Asn Ser Ala Val 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  41

Phe Gln Asn Thr Ala Leu 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  42

Met Gln Asn Thr Ala Ile 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  43

Leu Gln Asn Thr Ala Val 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  44

Met Gln Asn Thr Ala Val 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  45

Phe Asn Ser Glu Thr Val 
1               5       


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  46

Ala Ser Ser Pro Gly Ser Ile Asp Thr Gln Tyr 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  47

Ala Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  48

Ala Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  49

Ala Ser Ser Pro Gly Ser Thr Asp Ala Gln Tyr 
1               5                   10      


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  50

Ser Leu Leu Gln His Leu Ile Gly Leu 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  51

Ser Ile Leu Gln Thr Leu Ile Leu Val 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  52

Ser Leu Ile Glu His Leu Gln Gly Leu 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  53

Ser Leu Ile Gln His Leu Glu Glu Ile 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  54

Ser Leu Leu Lys Asn Leu Ile Tyr Leu 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  55

Ser Leu Leu Asn His Leu Pro Tyr Leu 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  56

Ser Leu Leu Gln His Val Leu Leu Leu 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  57

Ser Leu Leu Gln Lys Gln Ile Met Leu 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  58

Ser Leu Ser Gln Glu Leu Val Gly Val 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  59

Ser Val Leu Gly Ala Leu Ile Gly Val 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  60

Phe Met Asn Pro His Leu Ile Ser Val 
1               5                   


<210>  61
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  61

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  62

Ser Ile Leu Gln His Leu Leu Leu Val 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  63

Leu Leu Leu Ala His Ile Ile Ala Leu 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  64

His Leu Leu Ser Lys Leu Ile Ser Val 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  65

Lys Leu Leu Lys Asn Leu Ile Gly Ile 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  66

Lys Leu Ile Gln Phe Leu Ile Ser Leu 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  67

Tyr Met Leu Glu His Val Ile Thr Leu 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  68

Ile Leu Leu Glu His Ile Ile Met Cys 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  69

Ser Ile Leu Glu His Gln Ile Gln Val 
1               5                   


<210>  70
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  70

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  71

Ser Leu Leu Leu Lys Leu Ile Ala Val 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  72

Ser Leu Leu Asp Asn Met Ile Gly Val 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  73

Phe Leu Ile Gln His Leu Leu Gln Ala 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  74

Ser Leu Leu Asp Lys Ile Ile Gly Ala 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  75

Glu Leu Leu Gln Lys Val Ile Thr Leu 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  76

Ile Ile Ile Asn His Val Ile Ser Val 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  77

Phe Val Leu Gly His Phe Ile Leu Leu 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  78

Asn Leu Leu Pro His Ala Ile Asn Leu 
1               5                   


<210>  79
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  79

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Thr Arg Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Val Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  80
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  80

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Thr Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Val Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  81
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  81

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Thr Arg Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu His Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  82
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  82

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Thr Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Arg Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  83
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  83

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Asn 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Val Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Asn Ser Glu Thr Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  84
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  84

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Asn Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Val Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Tyr Gln Asn Thr Ala Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  85
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  85

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Asn Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Thr Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  86
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  86

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Asn 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu His Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Tyr Gln Asn Thr Ala Ile Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  87
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  87

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  88
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  88

Met Gln Leu Leu Arg Cys Phe Ser Ile Phe Ser Val Ile Ala Ser Val 
1               5                   10                  15      


Leu Ala Gln Glu Leu Thr Thr Ile Cys Glu Gln Ile Pro Ser Pro Thr 
            20                  25                  30          


Leu Glu Ser Thr Pro Tyr Ser Leu Ser Thr Thr Thr Ile Leu Ala Asn 
        35                  40                  45              


Gly Lys Ala Met Gln Gly Val Phe Glu Tyr Tyr Lys Ser Val Thr Phe 
    50                  55                  60                  


Val Ser Asn Cys Gly Ser His Pro Ser Thr Thr Ser Lys Gly Ser Pro 
65                  70                  75                  80  


Ile Asn Thr Gln Tyr Val Phe 
                85          


<210>  89
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  89

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg Asn Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu His Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Asn Ser Glu Thr Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  90
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  90

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Asn Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Asp Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Arg Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Lys Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Tyr Gln Asn Thr Ala Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  91
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  91

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Thr Arg Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Thr Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Tyr Gln Asn Thr Ala Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Ser Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  92
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  92

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Thr Lys Glu Phe Gln Asp 
            20                  25                  30          


Met His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Val Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His Leu 
    130                 135                 140                 


Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser 
145                 150                 155                 160 


Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu 
                165                 170                 175     


Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly 
            180                 185                 190         


Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser 
        195                 200                 205             


Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Arg Leu Thr Val Leu 
                245     


<210>  93
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  94
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  94

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu 
                245                 250                 255     


Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Thr Arg Glu Phe Gln 
            260                 265                 270         


Asp Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu 
        275                 280                 285             


Phe Tyr Phe Gly Pro Tyr Gly Val Glu Lys Lys Lys Gly Arg Ile Ser 
    290                 295                 300                 


Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp 
305                 310                 315                 320 


Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn 
                325                 330                 335     


Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His 
    370                 375                 380                 


Leu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile 
385                 390                 395                 400 


Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly 
                405                 410                 415     


Leu Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser 
            420                 425                 430         


Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe 
        435                 440                 445             


Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr 
    450                 455                 460                 


Phe Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro 
465                 470                 475                 480 


Gly Thr Arg Leu Thr Val Leu 
                485         


<210>  95
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  95

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu 
                245                 250                 255     


Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Thr Lys Glu Phe Gln 
            260                 265                 270         


Asp Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu 
        275                 280                 285             


Phe Tyr Phe Gly Pro Tyr Gly Arg Glu Lys Lys Lys Gly Arg Ile Ser 
    290                 295                 300                 


Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp 
305                 310                 315                 320 


Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn 
                325                 330                 335     


Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His 
    370                 375                 380                 


Leu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile 
385                 390                 395                 400 


Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly 
                405                 410                 415     


Leu Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser 
            420                 425                 430         


Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe 
        435                 440                 445             


Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr 
    450                 455                 460                 


Phe Cys Ala Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro 
465                 470                 475                 480 


Gly Thr Arg Leu Thr Val Leu 
                485         


<210>  96
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  96

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu 
                245                 250                 255     


Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr 
            260                 265                 270         


Asn Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu 
        275                 280                 285             


Phe Tyr Phe Gly Pro Tyr Gly Val Glu Lys Lys Lys Gly Arg Ile Ser 
    290                 295                 300                 


Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp 
305                 310                 315                 320 


Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn 
                325                 330                 335     


Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His 
    370                 375                 380                 


Leu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile 
385                 390                 395                 400 


Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly 
                405                 410                 415     


Leu Glu Leu Leu Ile Tyr Phe Asn Ser Glu Thr Val Ile Asp Asp Ser 
            420                 425                 430         


Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe 
        435                 440                 445             


Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr 
    450                 455                 460                 


Phe Cys Ala Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro 
465                 470                 475                 480 


Gly Thr Arg Leu Thr Val Leu 
                485         


<210>  97
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  97

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu 
                245                 250                 255     


Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Asn Lys Glu Phe Gln 
            260                 265                 270         


Asp Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu 
        275                 280                 285             


Phe Tyr Phe Gly Pro Tyr Gly Thr Glu Lys Lys Lys Gly Arg Ile Ser 
    290                 295                 300                 


Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp 
305                 310                 315                 320 


Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn 
                325                 330                 335     


Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His 
    370                 375                 380                 


Leu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile 
385                 390                 395                 400 


Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly 
                405                 410                 415     


Leu Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser 
            420                 425                 430         


Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe 
        435                 440                 445             


Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr 
    450                 455                 460                 


Phe Cys Ala Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro 
465                 470                 475                 480 


Gly Thr Arg Leu Thr Val Leu 
                485         


<210>  98
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  98

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu 
                245                 250                 255     


Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln 
            260                 265                 270         


Asp Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu 
        275                 280                 285             


Phe Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser 
    290                 295                 300                 


Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp 
305                 310                 315                 320 


Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn 
                325                 330                 335     


Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Val Ile Gln Ser Pro Arg His 
    370                 375                 380                 


Leu Val Thr Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile 
385                 390                 395                 400 


Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly 
                405                 410                 415     


Leu Glu Leu Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser 
            420                 425                 430         


Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe 
        435                 440                 445             


Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr 
    450                 455                 460                 


Phe Cys Ala Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro 
465                 470                 475                 480 


Gly Thr Arg Leu Thr Val Leu 
                485         


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  99

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  100
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  100

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        115                 120                 125             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
    130                 135                 140                 


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
145                 150                 155                 160 


Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 
                165                 170                 175     


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            180                 185                 190         


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
        195                 200                 205             


Gly Gln Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
    210                 215                 220                 


Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  101
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  101

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Val Ile Gln Ser Pro Arg His Leu Val Thr Glu Met Gly 
    130                 135                 140                 


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
145                 150                 155                 160 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
                165                 170                 175     


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
            180                 185                 190         


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
        195                 200                 205             


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
    210                 215                 220                 


Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
225                 230                 235                 240 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro 
465                 470 


<210>  102
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  102

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Leu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  103
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  103

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  104
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  104

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Leu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  105
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  105

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  106
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  106

Ile Met Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        115                 120                 125             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
    130                 135                 140                 


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
145                 150                 155                 160 


Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 
                165                 170                 175     


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            180                 185                 190         


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
        195                 200                 205             


Gly Gln Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
    210                 215                 220                 


Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  107
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  107

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Val Ile Gln Ser Pro Arg His Leu Val Thr Glu Met Gly 
    130                 135                 140                 


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
145                 150                 155                 160 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
                165                 170                 175     


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
            180                 185                 190         


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
        195                 200                 205             


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
    210                 215                 220                 


Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
225                 230                 235                 240 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro 
465                 470 


<210>  108
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  109
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  109

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  110
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  110

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Leu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  111
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  111

Ile Met Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  112
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  112

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  113
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  113

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  114
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  114

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  115
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  115

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  116
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  116

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Arg Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  117
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  117

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  118
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  119
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  119

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Val Ile Gln Ser Pro Arg His Leu Val Thr Glu Met Gly 
    130                 135                 140                 


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
145                 150                 155                 160 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
                165                 170                 175     


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
            180                 185                 190         


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
        195                 200                 205             


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
    210                 215                 220                 


Gly Ala Thr Asp Leu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
225                 230                 235                 240 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro 
465                 470 


<210>  120
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  120

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  121
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  121

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
    130                 135                 140                 


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
145                 150                 155                 160 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
                165                 170                 175     


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
            180                 185                 190         


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
        195                 200                 205             


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
    210                 215                 220                 


Gly Ala Thr Asp Leu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
225                 230                 235                 240 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro 
465                 470 


<210>  122
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  122

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        115                 120                 125             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
    130                 135                 140                 


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
145                 150                 155                 160 


Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 
                165                 170                 175     


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            180                 185                 190         


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
        195                 200                 205             


Gly Gln Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
    210                 215                 220                 


Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  123
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asp Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  124
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  124

Ile Met Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        115                 120                 125             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
    130                 135                 140                 


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
145                 150                 155                 160 


Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 
                165                 170                 175     


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            180                 185                 190         


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
        195                 200                 205             


Gly Gln Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
    210                 215                 220                 


Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  125
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  125

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Glu Ser Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  126
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  126

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        115                 120                 125             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
    130                 135                 140                 


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
145                 150                 155                 160 


Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 
                165                 170                 175     


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            180                 185                 190         


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
        195                 200                 205             


Gly Gln Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
    210                 215                 220                 


Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  127
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ala Tyr Ile Ser Tyr Trp 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  128
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  128

Ile Met Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        115                 120                 125             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
    130                 135                 140                 


Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
145                 150                 155                 160 


Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val 
                165                 170                 175     


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            180                 185                 190         


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
        195                 200                 205             


Gly Gln Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
    210                 215                 220                 


Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  129
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  129

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro 
            100                 105                 110 


<210>  130
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  130

Gly Val Ile Gln Ser Pro Arg His Leu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ala 
                85                  90                  95      


Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  131
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  131

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
    130                 135                 140                 


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
145                 150                 155                 160 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
                165                 170                 175     


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
            180                 185                 190         


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
        195                 200                 205             


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
    210                 215                 220                 


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
225                 230                 235                 240 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro 
465                 470 


<210>  132
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  132

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro 
            100                 105                 110 


<210>  133
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  133

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
    130                 135                 140                 


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
145                 150                 155                 160 


Phe Trp Tyr Arg Glu Thr Met Met Gln Gly Leu Glu Leu Leu Ile Tyr 
                165                 170                 175     


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
            180                 185                 190         


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
        195                 200                 205             


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
    210                 215                 220                 


Gly Ala Thr Asp Leu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
225                 230                 235                 240 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro 
465                 470 


<210>  134
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  134

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ala 
                85                  90                  95      


Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  135
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  135

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ala 
                85                  90                  95      


Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  136
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  136

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ser 
                85                  90                  95      


Thr Asp Ala Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  137
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  137

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Leu 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro 
            100                 105                 110 


<210>  138
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  138

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Ala Gly Ala 
                85                  90                  95      


Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  139
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  139

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ala 
                85                  90                  95      


Ile Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  140
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  140

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Ala Gly Ser 
                85                  90                  95      


Thr Asp Ala Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  141
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  141

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ser 
                85                  90                  95      


Ile Asp Ala Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  142
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  142

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Ile His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro 
            100                 105                 110 


<210>  143
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  143

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
    130                 135                 140                 


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
145                 150                 155                 160 


Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr 
                165                 170                 175     


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
            180                 185                 190         


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
        195                 200                 205             


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
    210                 215                 220                 


Gly Ala Thr Asp Leu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
225                 230                 235                 240 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro 
465                 470 


<210>  144
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  144

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Ala Gly Ala 
                85                  90                  95      


Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  145
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  145

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Thr Gly Ala 
                85                  90                  95      


Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  146
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  146

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ala 
                85                  90                  95      


Ile Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  147
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  147

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Ala Gly Ala 
                85                  90                  95      


Ile Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  148
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  148

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr Phe Gln 
        35                  40                  45              


Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Thr Gly Ala 
                85                  90                  95      


Ile Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  149
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  149

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro 
225                 


<210>  150
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  150

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro 
225                 


<210>  151
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  151

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Arg Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  152
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  152

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Leu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  153
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  153

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr 
    130                 135                 140                 


Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro Gly His Arg 
145                 150                 155                 160 


Ala Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu 
                165                 170                 175     


Phe Glu Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly 
            180                 185                 190         


Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Ser Ser Glu Met Asn Ile 
        195                 200                 205             


Ser Asn Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser 
    210                 215                 220                 


Pro Trp Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
225                 230                 235                 240 


Thr Val Thr Glu Asp Leu Lys Asn Glu Pro Lys Ser Ser Asp Lys Thr 
                245                 250                 255     


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  154
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  154

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln 
        115                 120                 125             


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    130                 135                 140                 


Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr 
                165                 170                 175     


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
        195                 200                 205             


Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp Thr Phe Gly 
    210                 215                 220                 


Gln Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  155
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  155

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  156
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  156

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Leu 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  157
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  157

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  158
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  158

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  159
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  159

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  160
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  160

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  161
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  161

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Ala 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  162
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  162

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  163
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  163

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Ile Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  164
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  164

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Ala 
        195                 200                 205             


Gly Ser Thr Asp Ala Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  165
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  165

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Ile Asp Ala Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  166
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  166

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Ile His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  167
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  167

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  168
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  168

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  169
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  169

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  170
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  170

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Ala 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  171
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  171

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  172
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  172

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Thr 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  173
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  173

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  174
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  174

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Ile Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  175
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  175

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asp 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  176
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  176

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  177
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  177

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  178
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  178

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Glu 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  179
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  179

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  180
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  180

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
    210                 215                 220                 


Ala Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  181
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  181

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  182
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  182

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Ala 
        195                 200                 205             


Gly Ala Ile Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  183
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  183

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  184
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  184

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  185
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  185

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Thr 
        195                 200                 205             


Gly Ala Ile Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  186
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  186

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  187

Ser Leu Ala Glu Gly Arg Leu Tyr Leu 
1               5                   


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  188

Asn Leu Leu Pro Lys Leu His Ile Val 
1               5                   


<210>  189
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  189

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  190
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  190

Ala Ile Val Asp Lys Val Pro Ser Val 
1               5                   


<210>  191
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  191

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asn 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  192

Ala Leu Ala Thr Leu Ile His Gln Val 
1               5                   


<210>  193
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  193

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  194
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  194

Ser Leu Asp Gln Pro Thr Gln Thr Val 
1               5                   


<210>  195
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  195

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Ala 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  196
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  196

Ser Leu Phe Arg Val Ile Thr Glu Val 
1               5                   


<210>  197
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  197

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Asp 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  198
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  198

Arg Leu Ala Val Tyr Ile Asp Arg Val 
1               5                   


<210>  199
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  199

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Glu 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  200
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  200

Pro Ile Leu Tyr Arg Pro Val Ala Val 
1               5                   


<210>  201
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  201

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Phe 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  202

Gly Leu Ala Thr Asp Val Gln Thr Val 
1               5                   


<210>  203
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  203

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn His 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  204

Lys Ile Tyr Glu Gly Gln Val Glu Val 
1               5                   


<210>  205
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  205

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Ile 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  206

Asn Leu Cys Pro Thr Arg Ile Glu Val 
1               5                   


<210>  207
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  207

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Leu 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  208

Phe Leu Leu Gln His Gln Thr Phe Leu 
1               5                   


<210>  209
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  209

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Lys 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  210
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  210

Leu Leu Ala Glu Arg Asp Leu Tyr Leu 
1               5                   


<210>  211
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  211

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Gln 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  212
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  212

Glu Leu Asp Val Arg Ile Thr Ala Leu 
1               5                   


<210>  213
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  213

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Arg 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  214
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  214

Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               


<210>  215
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  215

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Val 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  216
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  216

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Glu Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  217
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  217

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  218
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  218

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Arg Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  219
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  219

Ala Leu Tyr Asn Asn Ala Asp Met Arg 
1               5                   


<210>  220
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  220

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Lys Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  221
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  221

Ala Leu Tyr Asn Asn Asp Asp Met Arg 
1               5                   


<210>  222
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  222

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Gln Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  223
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  223

Ala Leu Tyr Asn Asn Glu Asp Met Arg 
1               5                   


<210>  224
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  224

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asn Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  225
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  225

Ala Leu Tyr Asn Asn Phe Asp Met Arg 
1               5                   


<210>  226
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  226

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Tyr Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  227
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  227

Ala Leu Tyr Asn Asn His Asp Met Arg 
1               5                   


<210>  228
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  228

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Ser Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  229
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  229

Ala Leu Tyr Asn Asn Ile Asp Met Arg 
1               5                   


<210>  230
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  230

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Arg Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  231
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  231

Ala Leu Tyr Asn Asn Lys Asp Met Arg 
1               5                   


<210>  232
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  232

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp His Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  233
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  233

Ala Leu Tyr Asn Asn Gln Asp Met Arg 
1               5                   


<210>  234
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  234

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  235
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  235

Ala Leu Tyr Asn Asn Arg Asp Met Arg 
1               5                   


<210>  236
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  236

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Ala Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  237
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  237

Ala Leu Tyr Asn Asn Val Asp Met Arg 
1               5                   


<210>  238
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  238

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Gln Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  239
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  239

Ala Ser Ser Pro Gly Ala Thr Asp Leu Gln Tyr 
1               5                   10      


<210>  240
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  240

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Asn Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  241
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  241

Ala Ser Ser Pro Gly Ala Thr Asp Arg Gln Tyr 
1               5                   10      


<210>  242
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  242

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Phe Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  243
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  243

Ala Ser Ser Pro Gly Ala Thr Asp His Gln Tyr 
1               5                   10      


<210>  244
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  244

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Tyr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  245
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  245

Ala Ser Ser Pro Gly Ala Thr Asp Glu Gln Tyr 
1               5                   10      


<210>  246
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  246

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Ile Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  247
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  247

Ala Ser Ser Pro Gly Ala Thr Asp Ala Gln Tyr 
1               5                   10      


<210>  248
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  248

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  249
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  249

Ala Ser Ser Pro Gly Ala Thr Asp Gln Gln Tyr 
1               5                   10      


<210>  250
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  250

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp Arg Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  251
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  251

Ala Ser Ser Pro Gly Ala Thr Asp Asn Gln Tyr 
1               5                   10      


<210>  252
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  252

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp His Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  253
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  253

Ala Ser Ser Pro Gly Ala Thr Asp Phe Gln Tyr 
1               5                   10      


<210>  254
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  254

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  255
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  255

Ala Ser Ser Pro Gly Ala Thr Asp Tyr Gln Tyr 
1               5                   10      


<210>  256
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  256

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp Ala Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  257
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  257

Ala Ser Ser Pro Gly Ala Thr Asp Ile Gln Tyr 
1               5                   10      


<210>  258
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  258

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp Gln Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  259
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  259

Ala Ser Ser Pro Gly Ala Thr Asp Val Gln Tyr 
1               5                   10      


<210>  260
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  260

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp Asn Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  261
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  261

Ala Ser Ser Pro Gly Ser Thr Asp Arg Gln Tyr 
1               5                   10      


<210>  262
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  262

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp Phe Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  263
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  263

Ala Ser Ser Pro Gly Ser Thr Asp His Gln Tyr 
1               5                   10      


<210>  264
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  264

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp Tyr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  265
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  265

Ala Ser Ser Pro Gly Ser Thr Asp Glu Gln Tyr 
1               5                   10      


<210>  266
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  266

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp Ile Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  267
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  267

Ala Ser Ser Pro Gly Ser Thr Asp Gln Gln Tyr 
1               5                   10      


<210>  268
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  268

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  269
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  269

Ala Ser Ser Pro Gly Ser Thr Asp Asn Gln Tyr 
1               5                   10      


<210>  270
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  270

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Glu Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  271
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  271

Ala Ser Ser Pro Gly Ser Thr Asp Phe Gln Tyr 
1               5                   10      


<210>  272
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  272

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Arg Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  273
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  273

Ala Ser Ser Pro Gly Ser Thr Asp Tyr Gln Tyr 
1               5                   10      


<210>  274
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  274

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Lys Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  275
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  275

Ala Ser Ser Pro Gly Ser Thr Asp Ile Gln Tyr 
1               5                   10      


<210>  276
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  276

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Gln Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  277
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  277

Ala Ser Ser Pro Gly Ser Thr Asp Val Gln Tyr 
1               5                   10      


<210>  278
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  278

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Asn Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  279
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  279

Ala Ser Ser Ser Gly Ala Thr Asp Val Gln Tyr 
1               5                   10      


<210>  280
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  280

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Tyr Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  281
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  281

Ala Ser Ser Ala Gly Ala Thr Asp Lys Gln Tyr 
1               5                   10      


<210>  282
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  282

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ser Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  283
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  283

Ala Ser Ser Pro Gly Ala Ile Asp Lys Gln Tyr 
1               5                   10      


<210>  284
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  284

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ser Thr Asp Ala Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  285
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  285

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Arg Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  286
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  286

Gly Gly Gly Gly Ser 
1               5   


<210>  287
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  287

Gly Gly Gly Ala Ser 
1               5   


<210>  288
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  288

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  289
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  289

Ala Ala Ala Gly Gly Ser Gly Gly 
1               5               


<210>  290
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  290

Gly Gly Gly Ser 
1               


<210>  291
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  291

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Tyr 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  292
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  292

Ala Ser Ser Ala Gly Ser Thr Asp Ala Gln Tyr 
1               5                   10      


<210>  293
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  293

Ala Ser Ser Arg Gly Ser Thr Asp Ala Gln Tyr 
1               5                   10      


<210>  294
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  294

Ala Ser Ser Pro Gly Ser Ile Asp Ala Gln Tyr 
1               5                   10      


<210>  295
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  295

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Leu 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        115                 120                 125             


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
    130                 135                 140                 


Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr 
                165                 170                 175     


Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn 
    210                 215                 220                 


Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470         


<210>  296
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  296

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
        115                 120                 125             


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
    130                 135                 140                 


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu 
145                 150                 155                 160 


Leu Ile Tyr Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro 
                165                 170                 175     


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Asp Ser Phe Ser Thr Leu 
            180                 185                 190         


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
        195                 200                 205             


Ser Ser Pro Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg 
    210                 215                 220                 


Leu Thr Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455         


<210>  297
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  297

Ala Ser Ser Thr Gly Ala Thr Asp Lys Gln Tyr 
1               5                   10      


<210>  298
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  298

Ala Ser Ser Ala Gly Ala Ile Asp Lys Gln Tyr 
1               5                   10      


<210>  299
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  299

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Leu 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Arg Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  300
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  300

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
        115                 120                 125             


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu 
    130                 135                 140                 


Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile Tyr 
145                 150                 155                 160 


Phe Gln Asn Thr Ala Val Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
                165                 170                 175     


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
            180                 185                 190         


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro 
        195                 200                 205             


Gly Ala Thr Asp Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
    210                 215                 220                 


Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro 
    450                 


<210>  301
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  301

Ala Ser Ser Thr Gly Ala Ile Asp Lys Gln Tyr 
1               5                   10      


<210>  302
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  302

Ala Ser Ser Ser Gly Ala Thr Asp Thr Gln Tyr 
1               5                   10      


<210>  303
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  303

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro Val Lys Glu Phe Gln Asp 
            20                  25                  30          


Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
        35                  40                  45              


Tyr Phe Gly Pro Tyr Gly Lys Glu Lys Lys Lys Gly Arg Ile Ser Ala 
    50                  55                  60                  


Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Thr Asp Ser 
65                  70                  75                  80  


Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Leu Tyr Asn Asn Leu 
                85                  90                  95      


Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
        115                 120                 125             


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
    130                 135                 140                 


Tyr Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Gln Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Arg Asn Asp Val Thr 
                165                 170                 175     


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
            180                 185                 190         


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
        195                 200                 205             


Thr Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly 
    210                 215                 220                 


Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro 
225                 230                 235                 240 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro 
465         


<210>  304
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  304

His Leu Leu Pro Glu Val Phe Thr Leu 
1               5                   


<210>  305
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  305

Asp Val Leu Asn Pro Leu Ile Thr Ala 
1               5                   


<210>  306
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  306

Leu Thr Leu Gly His Leu Met Gly Val 
1               5                   


<210>  307
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  307

Phe Leu Leu Ser Glu Pro Val Ala Leu 
1               5                   


<210>  308
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  308

Leu Leu Thr Pro Ala Val Gln Asp Leu 
1               5                   


<210>  309
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  309

Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
1               5                   


<210>  310
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  310

Phe Leu Asp Thr Ile Lys Ser Asn Leu 
1               5                   


<210>  311
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  311

Ser Leu Leu Val His Asn Val Ser Val 
1               5                   


<210>  312
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  312

Thr Leu Gln Glu Phe Leu Lys Leu Ala 
1               5                   


<210>  313
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  313

Phe Leu Ile Thr Gln Leu Lys Met Leu 
1               5                   


<210>  314
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  314

Val Leu Asp Ser Val Lys Leu Glu Ala 
1               5                   


<210>  315
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  315

Ile Leu Gln Thr Phe Lys Thr Val Ala 
1               5                   


<210>  316
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  316

Ile Leu Ala Ser Glu Leu Ser Arg Leu 
1               5                   


<210>  317
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  317

Ser Leu Asn Leu Arg Glu Thr Asn Leu 
1               5                   


<210>  318
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  318

Ala Leu Leu Gln His Leu Ile Gly Leu 
1               5                   


<210>  319
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  319

Ser Leu Ala Gln His Leu Ile Gly Leu 
1               5                   


<210>  320
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  320

Ser Leu Leu Ala His Leu Ile Gly Leu 
1               5                   


<210>  321
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  321

Ser Leu Leu Gln Ala Leu Ile Gly Leu 
1               5                   


<210>  322
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  322

Ser Leu Leu Gln His Ala Ile Gly Leu 
1               5                   


<210>  323
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  323

Ser Leu Leu Gln His Leu Ala Gly Leu 
1               5                   


<210>  324
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  324

Ser Leu Leu Gln His Leu Ile Ala Leu 
1               5                   


<210>  325
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  325

Met Gln Leu Leu Arg Cys Phe Ser Ile Phe Ser Val Ile Ala Ser Val 
1               5                   10                  15      


Leu Ala Gln Glu Leu Thr Thr Ile Cys Glu Gln Ile Pro Ser Pro Thr 
            20                  25                  30          


Leu Glu Ser Thr Pro Tyr Ser Leu Ser Thr Thr Thr Ile Leu Ala Asn 
        35                  40                  45              


Gly Lys Ala Met Gln Gly Val Phe Glu Tyr Tyr Lys Ser Val Thr Phe 
    50                  55                  60                  


Val Ser Asn Cys Gly Ser His Pro Ser Thr Thr Ser Lys Gly Ser Pro 
65                  70                  75                  80  


Ile Asn Thr Gln Tyr Val Phe Gly Gly Gly Gly Ser Asp Tyr Lys Asp 
                85                  90                  95      


Asp Asp Asp Lys Gly Gly Gly Ala Ser Ile Leu Asn Val Glu Gln Ser 
            100                 105                 110         


Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys 
        115                 120                 125             


Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu 
    130                 135                 140                 


Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp 
145                 150                 155                 160 


Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly 
                165                 170                 175     


Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr 
            180                 185                 190         


Tyr Leu Cys Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly 
        195                 200                 205             


Thr Arg Leu Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
                245                 250                 255     


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            260                 265                 270         


Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn 
        275                 280                 285             


Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    290                 295                 300                 


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
305                 310                 315                 320 


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly Ser 
                325                 330                 335     


Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Ala 
            340                 345                 350         


Ala Ala Gly Gly Ser Gly Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp 
        355                 360                 365             


Leu 
    


<210>  326
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X1
<222>  (6)..(6)
<223>  X1 is L or Y

<400>  326

Ala Leu Tyr Asn Asn Xaa Asp Met Arg 
1               5                   


<210>  327
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X1
<222>  (4)..(4)
<223>  X1 is P, A or T

<220>
<221>  X2
<222>  (6)..(6)
<223>  X2 is A or S

<220>
<221>  X3
<222>  (7)..(7)
<223>  X3 is T or I

<220>
<221>  X4
<222>  (9)..(9)
<223>  X4 is K or A

<400>  327

Ala Ser Ser Xaa Gly Xaa Xaa Asp Xaa Gln Tyr 
1               5                   10      


<210>  328
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Glu Arg Arg Arg Leu Trp Gly Ser Ile Gln Ser Arg Tyr Ile Ser 
1               5                   10                  15      


Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly Gln 
            20                  25                  30          


Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu Leu 
        35                  40                  45              


Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly Arg 
    50                  55                  60                  


His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr Cys 
65                  70                  75                  80  


Leu Pro Leu Gly Val Leu Met Lys Gly Gln His Leu His Leu Glu Thr 
                85                  90                  95      


Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu Val 
            100                 105                 110         


Arg Pro Arg Arg Trp Lys Leu Gln Val Leu Asp Leu Arg Lys Asn Ser 
        115                 120                 125             


His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu Tyr 
    130                 135                 140                 


Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Thr Lys Lys Arg Lys 
145                 150                 155                 160 


Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Ile Pro Val Glu 
                165                 170                 175     


Val Leu Val Asp Leu Phe Leu Lys Glu Gly Ala Cys Asp Glu Leu Phe 
            180                 185                 190         


Ser Tyr Leu Ile Glu Lys Val Lys Arg Lys Lys Asn Val Leu Arg Leu 
        195                 200                 205             


Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile Lys 
    210                 215                 220                 


Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu Val 
225                 230                 235                 240 


Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr Leu 
                245                 250                 255     


Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His Ala 
            260                 265                 270         


Ser Ser Tyr Ile Ser Pro Glu Lys Glu Glu Gln Tyr Ile Ala Gln Phe 
        275                 280                 285             


Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val Asp 
    290                 295                 300                 


Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His Val 
305                 310                 315                 320 


Met Asn Pro Leu Glu Thr Leu Ser Ile Thr Asn Cys Arg Leu Ser Glu 
                325                 330                 335     


Gly Asp Val Met His Leu Ser Gln Ser Pro Ser Val Ser Gln Leu Ser 
            340                 345                 350         


Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu Pro 
        355                 360                 365             


Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu Val 
    370                 375                 380                 


Phe Asp Glu Cys Gly Ile Thr Asp Asp Gln Leu Leu Ala Leu Leu Pro 
385                 390                 395                 400 


Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Tyr Gly Asn 
                405                 410                 415     


Ser Ile Ser Ile Ser Ala Leu Gln Ser Leu Leu Gln His Leu Ile Gly 
            420                 425                 430         


Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser Tyr 
        435                 440                 445             


Glu Asp Ile His Gly Thr Leu His Leu Glu Arg Leu Ala Tyr Leu His 
    450                 455                 460                 


Ala Arg Leu Arg Glu Leu Leu Cys Glu Leu Gly Arg Pro Ser Met Val 
465                 470                 475                 480 


Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe Tyr 
                485                 490                 495     


Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
            500                 505                 


<210>  329
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  329

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  330
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  330

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly 
            20      


<210>  331
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  331

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro 
            


<210>  332
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  332

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
        35                  40                  45              


Pro Glu Leu Leu Gly 
    50              


<210>  333
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  333

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly 
        


<210>  334
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X1
<222>  (1)..(1)
<223>  X1 is V, T, N, I or S, preferably V; T or N, most preferably V,

<220>
<221>  X2
<222>  (2)..(2)
<223>  X2 is K, R, S or A, more preferably K or R, most preferably K

<220>
<221>  X3
<222>  (6)..(6)
<223>  X3 is D or N, preferably D

<400>  334

Xaa Xaa Glu Phe Gln Xaa 
1               5       


<210>  335
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X1
<222>  (6)..(6)
<223>  X1 is K, R, T or V, preferably K or R, most preferably K

<400>  335

Phe Gly Pro Tyr Gly Xaa Glu 
1               5           


<210>  336
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X1
<222>  (6)..(6)
<223>  X1 is L, Y, H, Q, A, I, K, R, V, D, E, F or N, preferably L, Y, 
       H, Q, A, I, K or R, more preferably L, Y, H, Q or A, most 
       preferably L or Y

<400>  336

Ala Leu Tyr Asn Asn Xaa Asp Met Arg 
1               5                   


<210>  337
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X1
<222>  (1)..(1)
<223>  X1 is F, Y, M or L, preferably F or Y, most preferably F

<220>
<221>  X2
<222>  (2)..(2)
<223>  X2 is Q or N, preferably Q (if X2 is N, then X3 is also N)

<220>
<221>  X3
<222>  (3)..(3)
<223>  X3 is N or S, preferably N

<220>
<221>  X4
<222>  (4)..(4)
<223>  X4 is T, S, or E, preferably T or S, most preferably T (if X4 is 
       S, then X2 is Q)

<220>
<221>  X5
<222>  (5)..(5)
<223>  X5 is A or T, preferably A

<220>
<221>  X6
<222>  (6)..(6)
<223>  X6 is V, I, L or T, preferably V or I, most preferably V

<400>  337

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  338
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X1
<222>  (4)..(4)
<223>  X1 is P, R, A, T, or S, preferably P, T or A, most preferably P

<220>
<221>  X2
<222>  (6)..(6)
<223>  X2 is A or S, preferably A

<220>
<221>  X3
<222>  (7)..(7)
<223>  X3 is T or I, preferably T

<220>
<221>  X4
<222>  (9)..(9)
<223>  X4 is K, A, L, I, V, R, Q, N, Y, T, H, E or F, preferably K, A, 
       L, I, V, R, Q N, or Y, more preferably K, A, L, I, V or R, most 
       preferably K or A

<400>  338

Ala Ser Ser Xaa Gly Xaa Xaa Asp Xaa Gln Tyr 
1               5                   10      


<210>  339
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  339

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  340
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  340

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  341
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  341

Ala Ala Val Ile Asp Asn Asp Gln Gly Gly Ile Leu Thr 
1               5                   10              


<210>  342
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  342

Pro Gly His Arg Ala 
1               5   


<210>  343
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  343

Tyr Val His Gly Glu Glu 
1               5       


<210>  344
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  344

Ala Ser Ser Pro Trp Asp Ser Pro Asn Val Gln Tyr 
1               5                   10          


<210>  345
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  345

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Lys Phe Thr Cys Ser Phe Pro 
            20                  25      


<210>  346
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  346

Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly 
1               5                   10                  15      


Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
            20                  25      


<210>  347
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  347

Leu His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
1               5                   10                  15      


Tyr 
    


<210>  348
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  348

Ile His Trp Tyr Arg Lys Glu Thr Ala Lys Ser Pro Glu Phe Leu Phe 
1               5                   10                  15      


Tyr 
    


<210>  349
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  349

Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr 
1               5                   10                  15      


Ser Tyr Leu Tyr Ile Thr Asp Ser Gln Pro Glu Asp Ser Ala Thr Tyr 
            20                  25                  30          


Leu Cys 
        


<210>  350
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  350

Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro 
1               5                   10      


<210>  351
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  351

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile 
            20                  


<210>  352
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  352

Gly Val Ile Gln Ser Pro Arg His Leu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile 
            20                  


<210>  353
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  353

Leu Phe Trp Tyr Arg Glu Thr Pro Met Gln Gly Leu Glu Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  354
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  354

Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro 
1               5                   10                  15      


Asn Asp Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  355
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  355

Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser Ala Lys Met Pro 
1               5                   10                  15      


Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser Glu Pro Arg Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  356
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  356

Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
1               5                   10  


<210>  357
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  357

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val 
    130                 135                 140                 


Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly Gln Gln Val Thr 
145                 150                 155                 160 


Leu Ser Cys Ser Pro Ile Pro Gly His Arg Ala Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu Tyr Val His Gly 
            180                 185                 190         


Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe Ser Gly Arg Gln 
        195                 200                 205             


Phe Ser Asn Ser Ser Ser Glu Met Asn Ile Ser Asn Leu Glu Leu Gly 
    210                 215                 220                 


Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Pro Trp Asp Ser Pro Asn 
225                 230                 235                 240 


Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu 
                245                 250                 255     


Lys Asn 
        


<210>  358
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  358

Gly Gly Gly Gly Ser Ala Ala Ala 
1               5               


<210>  359
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X1
<222>  (1)..(1)
<223>  X1 is F, Y, M or L, preferably F or Y, most preferably F

<220>
<221>  X3
<222>  (3)..(3)
<223>  X3 is N or S, preferably N

<220>
<221>  X5
<222>  (5)..(5)
<223>  X5 is A or T, preferably A

<220>
<221>  X6
<222>  (6)..(6)
<223>  X6 is V, I, L or T, preferably V or I, most preferably V

<400>  359

Xaa Gln Xaa Thr Xaa Xaa 
1               5       


<210>  360
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  360

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser 
            100                 105                 110         


Pro Ala Pro Pro Val Ala Gly 
        115                 


<210>  361
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  361

Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
1               5                   10                  15      


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
            20                  25                  30          


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
    50                  55                  60                  


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
65                  70                  75                  80  


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
                85                  90                  95      


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
            100                 105                 110         


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
        115                 120                 125             


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140     


<210>  362
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  362

Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Ser Arg Gly 
            


<210>  363
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X2
<222>  (6)..(6)
<223>  X2 is A or S, preferably A

<220>
<221>  X4
<222>  (9)..(9)
<223>  X4 is T, K or A, preferably K or A, more preferably K

<400>  363

Ala Ser Ser Pro Gly Xaa Thr Asp Xaa Gln Tyr 
1               5                   10      


<210>  364
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X2
<222>  (6)..(6)
<223>  X2 is A or S, preferably A

<220>
<221>  X3
<222>  (7)..(7)
<223>  X3 is T or I

<220>
<221>  X4
<222>  (9)..(9)
<223>  X4 is T, K or A, preferably K or A, more preferably K

<400>  364

Ala Ser Ser Pro Gly Xaa Xaa Asp Xaa Gln Tyr 
1               5                   10      


<210>  365
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X3
<222>  (7)..(7)
<223>  X3 is T or I, preferably I

<220>
<221>  X4
<222>  (9)..(9)
<223>  X4 is K or A, preferably K

<400>  365

Ala Ser Ser Pro Gly Ala Xaa Asp Xaa Gln Tyr 
1               5                   10      


<210>  366
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  366

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  367
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  367

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Lys Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  368
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  368

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Lys Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  369
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  369

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Arg Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  370
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  370

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Arg Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  371
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  371

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr His Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  372
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  372

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Lys Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  373
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  373

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Lys Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  374
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  374

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Arg Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  375
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  375

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro His Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  376
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  376

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Lys Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  377
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  377

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Lys Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  378
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  378

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Arg Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  379
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  379

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Lys Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  380
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  380

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Arg Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  381
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  381

Ser Tyr Val Met His 
1               5   


<210>  382
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence


<220>
<221>  X1
<222>  (12)..(12)
<223>  X1 is A or N

<220>
<221>  X2
<222>  (13)..(13)
<223>  X2 is E or Q

<220>
<221>  X3
<222>  (16)..(16)
<223>  X3 is Q or K

<400>  382

Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Xaa Xaa Lys Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  383
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  383

Ser Ala Thr Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  384
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified or unmodified human sequence

<400>  384

Asp Thr Ser Lys Leu Ala Ser 
1               5           


