               SEQUENCE LISTING

<110> Merck Patent GmbH

<120> HER2 targeting Fc antigen binding fragment-drug conjugates

<130> P021-066 EP-EPA

<140> EP21171859.8
<141> 0021-05-03

<150> EP21171859.8
<151> 2021-05-03

<160> 23

<170> BiSSAP 1.3.6

<210> 1
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> S5 (native Q295)

<400> 1
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Ser Gly Asn Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Glu Arg Met Trp Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly 
225         

<210> 2
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> S5-C265

<400> 2
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Cys Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Ser Gly Asn Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Glu Arg Met Trp Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly 
225         

<210> 3
<211> 232
<212> PRT
<213> Artificial Sequence


<220> 
<223> S5-NLLQGA

<400> 3
Leu Leu Gln Gly Ala Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser 
        35                  40                  45              
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Tyr Leu Ser Gly Asn Val 
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         
Val Pro Arg His Ser Glu Arg Met Trp Arg Trp Ala His Gly Asn Val 
        195                 200                 205             
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 
Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230         

<210> 4
<211> 237
<212> PRT
<213> Artificial Sequence


<220> 
<223> S5-NG4S-LLQGA

<400> 4
Leu Leu Gln Gly Ala Gly Gly Gly Gly Ser Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              
Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Tyr 
    130                 135                 140                 
Leu Ser Gly Asn Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         
Tyr Ser Lys Leu Thr Val Pro Arg His Ser Glu Arg Met Trp Arg Trp 
        195                 200                 205             
Ala His Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235         

<210> 5
<211> 237
<212> PRT
<213> Artificial Sequence


<220> 
<223> S5-CG4S-LLQGA

<400> 5
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Ser Gly Asn Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Glu Arg Met Trp Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly Gly Gly Gly Gly Ser Leu Leu Gln Gly Ala 
225                 230                 235         

<210> 6
<211> 242
<212> PRT
<213> Artificial Sequence


<220> 
<223> S5-C(G4S)2-LLQGA

<400> 6
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Ser Gly Asn Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Glu Arg Met Trp Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Leu Gln 
225                 230                 235                 240 
Gly Ala 
        

<210> 7
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> S19 (native Q295)

<400> 7
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Ser Asp Ser Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Glu Thr Met Arg Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly 
225         

<210> 8
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> S19-C265

<400> 8
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Cys Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Ser Asp Ser Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Glu Thr Met Arg Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly 
225         

<210> 9
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> FS (native Q295)

<400> 9
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Phe Phe Thr Tyr Trp Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Arg Arg Arg 
            180                 185                 190         
Trp Thr Ala Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220         

<210> 10
<211> 228
<212> PRT
<213> Artificial Sequence


<220> 
<223> αH H10 (Q295)

<400> 10
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Cys Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Tyr Gly Asp Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Ala Arg Met Trp Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Cys Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Gly Glu Cys 
225             

<210> 11
<211> 228
<212> PRT
<213> Artificial Sequence


<220> 
<223> αH H10C265 (D265C)

<400> 11
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Cys Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Cys Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Tyr Gly Asp Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Ala Arg Met Trp Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Cys Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Gly Glu Cys 
225             

<210> 12
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> H242-9 (taken from 10.1093/protein/gzq005)

<400> 12
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu His Gly Asp Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Ala Arg Tyr Ser 
            180                 185                 190         
Pro Arg Met Leu Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly 
225         

<210> 13
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> STAB1 (taken from 10.1093/protein/gzs102)

<400> 13
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Ser Gly Asp Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Glu Arg Met Trp Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly 
225         

<210> 14
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> STAB11 (taken from 10.1093/protein/gzs102)

<400> 14
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Thr Gly Asn Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Glu Arg Met Trp Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly 
225         

<210> 15
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> STAB14 (taken from 10.1093/protein/gzs102)

<400> 15
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Leu Ser Gly Asp Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Asp Ala Met Arg Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly 
225         

<210> 16
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> STAB15 (taken from 10.1093/protein/gzs102)

<400> 16
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Tyr Arg Ser Gly Asp Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser 
            180                 185                 190         
Glu Arg Met Trp Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly 
225         

<210> 17
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> T-Fab (K183C, V205C)

<400> 17
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Cys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Cys Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 18
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> huFc (native Q295)

<400> 18
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220         

<210> 19
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> huFc-C265

<400> 19
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Cys Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220         

<210> 20
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> huFc-NLLQGA

<400> 20
Leu Leu Gln Gly Ala Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser 
        35                  40                  45              
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 
Ser Pro Gly 
225         

<210> 21
<211> 232
<212> PRT
<213> Artificial Sequence


<220> 
<223> huFc-NG4S-LLQGA

<400> 21
Leu Leu Gln Gly Ala Gly Gly Gly Gly Ser Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              
Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 
Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230         

<210> 22
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> Light Chain

<400> 22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Thr Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 23
<211> 450
<212> PRT
<213> Artificial Sequence


<220> 
<223> Heavy Chain

<400> 23
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          
Gly Val Asn Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Met Ile Trp Gly Asp Gly Asn Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Met Leu Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Glu Arg Asp Tyr Arg Leu Asp Tyr Trp Gly Gln Gly Ser Leu Val 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Tyr Leu Ser Gly Asn Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Arg His Ser Glu 
                405                 410                 415     
Arg Met Trp Arg Trp Ala His Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly 
    450 

