﻿                         序列表

<110>  斯微（上海）生物科技股份有限公司
 
<120>  一种疫苗试剂和接种方法

<130>  P2022TC2067

<150>  CN202110488951.8
<151>  2021-05-04

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  野生型S蛋白

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  212氨基酸序列

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  3
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  213氨基酸序列

<400>  3

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gln Ser Ala Gln Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  4
<211>  3825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  212 DNA ORF

<400>  4
atgttcgtat tcctagtgct gctgcccctg gtgagcagcc agtgcgtgaa cctgaccaca       60

cgcactcagc tgccaccagc ctacaccaac tcattcacca ggggcgtgta ctatcctgac      120

aaggtgttca ggagcagcgt gctgcactcc acccaggatc tgttcctgcc cttcttcagc      180

aacgtgacat ggttccacgc catccacgtg agcgggacaa acggcaccaa gcggtttgac      240

aatcccgttc tgccattcaa cgatggcgtg tacttcgcca gcaccgagaa aagcaacatc      300

atccggggct ggatcttcgg caccacactg gacagcaaga cccagagtct gctgatcgtg      360

aacaacgcca ccaacgtggt gatcaaggtg tgtgagttcc agttctgtaa tgaccccttc      420

ctgggggtct attaccacaa gaacaataaa agctggatgg agagcgagtt tcgggtgtac      480

agtagtgcca acaactgtac attcgagtac gtgtcccagc cattcctgat ggacctggag      540

gggaagcagg ggaacttcaa gaacctgcgg gagttcgtgt ttaagaatat cgacggatat      600

tttaagatct actccaagca cacccccatc aacctggtgc gggatctgcc ccagggcttc      660

agcgccctgg agcccctggt ggacctgccc atcgggatca acatcacccg gttccagacc      720

ctgctggccc tgcaccggag ttacctgacc ccaggtgact ccagcagcgg ctggacagcc      780

ggggctgcag cctactacgt gggctacctg cagccccgga ccttcctcct gaagtacaat      840

gagaacggca ccatcaccga tgccgtggat tgtgctctgg accccctgtc tgagaccaag      900

tgcaccctga aaagcttcac cgtggagaag gggatctacc agacaagcaa ctttcgggtg      960

cagcccaccg agagtatcgt gaggttcccc aacatcacca acctgtgtcc attcggggag     1020

gtgttcaacg ccacccggtt cgcaagcgtg tacgcttgga accggaagcg catcagcaat     1080

tgcgtggctg attacagcgt gctgtacaac agcgcctcct tcagcacatt caagtgctac     1140

ggcgtctccc ccacaaagct gaacgatctg tgtttcacca acgtgtacgc agacagcttt     1200

gtgatccggg gagacgaggt gcggcagatc gcacccgggc agaccggcaa gattgctgac     1260

tacaattaca agctgcctga tgacttcaca ggctgcgtga ttgcctggaa cagcaataac     1320

ctggacagca aggtgggagg taattacaat tacctctacc ggctgttcag gaagtccaat     1380

ctgaagccct tcgagaggga catctccacc gagatctacc aggctgggtc caccccatgc     1440

aatggggtgg agggcttcaa ctgctacttc cccctgcagt cctacggctt ccagcccacc     1500

aatggggtgg gctaccagcc ctaccgggtg gtggtgctga gcttcgagct cctgcacgcc     1560

cccgccactg tgtgcggccc caagaagtcc accaacctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acgggttgac cgggactggg gtgctcacag agagcaacaa gaagttcctg     1680

cccttccagc agttcggaag ggacatcgcc gacaccacgg atgccgtgag ggatccccag     1740

accctcgaga tcctggacat cacgccatgc tccttcgggg gcgtgagcgt gatcactcct     1800

ggcacaaaca cctccaacca ggtggctgtg ctgtaccagg gcgtgaactg caccgaggtg     1860

cctgtggcca tccatgctga ccagctgacc cccacctggc gggtctacag caccggcagc     1920

aacgtgttcc agacccgggc cggctgcctg atcggggccg agcacgtgaa caacagctac     1980

gagtgcgata tccccatcgg cgccggcatc tgcgctagct accagacaca gaccaatagc     2040

cccagacggg ctaggtctgt ggctagccag agcatcatcg cctacactat gtctctgggc     2100

gcagagaata gtgtggctta cagcaacaac agcatcgcca ttcccactaa tttcacaatt     2160

agtgtgacca ccgagatcct gcctgtgagc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gggatagcac cgagtgcagc aacctgctgc tgcagtacgg cagcttctgc     2280

acacagctga accgggccct gaccggtatc gctgtggagc aggacaagaa cacccaggag     2340

gtgtttgcgc aggtgaagca gatctacaag acccctccta tcaaggactt cgggggcttt     2400

aacttcagcc agatcctgcc agacccctcc aagccctcca agaggagctt catcgaggat     2460

ctcctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta cggagattgc     2520

ctgggcgaca tcgccgccag ggatctcatc tgcgcccaga agttcaacgg cctgaccgtg     2580

ctgccccccc tgctgaccga tgagatgatc gctcagtaca ccagcgccct gctggctggg     2640

accatcacca gcgggtggac cttcggggcc ggcgccgccc tgcagatccc cttcgccatg     2700

cagatggcct accggttcaa cggtattggg gtgacccaga atgtgctgta tgagaaccag     2760

aagctgatcg ccaaccagtt caactctgcc atcggcaaga tccaggactc cctgagcagc     2820

actgccagcg ccctgggcaa gctgcaggac gtggtgaacc agaacgccca ggccctgaat     2880

accctggtga agcagctgtc cagcaacttc ggggccatca gcagcgtgct gaacgacatc     2940

ctgtcccgcc tggacccacc agaggcagag gtgcagatcg atcggctgat cacaggtagg     3000

ctgcagagcc tgcagaccta cgtgacccag cagctgatcc gcgccgctga gattagggcc     3060

agcgccaacc tggccgccac taagatgagc gagtgcgtgc tgggccagag caagcgggtg     3120

gacttctgcg gcaaggggta tcacctgatg agcttccctc agtccgcccc ccacggggtg     3180

gtgttcctgc acgtgacata cgtgcccgcc caggagaaga acttcaccac cgcccctgcc     3240

atctgccacg atggcaaggc ccactttccc cgggagggcg tgttcgtgtc caatggcaca     3300

cattggttcg tgacccagcg gaacttctac gagccacaga tcattaccac tgacaatacc     3360

tttgtcagtg gtaactgtga cgtggtgatc ggcattgtga acaacacagt gtacgatcct     3420

ctgcagccag agctggacag cttcaaggag gagctggaca agtacttcaa gaaccacacc     3480

agccccgacg tggatcttgg agacatctct ggcatcaacg ccagcgtggt caacatccag     3540

aaggagattg accgcctgaa cgaggttgcc aagaacctga acgagagtct gatcgacctc     3600

caggagcttg gcaagtacga gcagtacatc aagtggccat ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgcat gacctcttgt     3720

tgcagctgcc tgaaggggtg ctgcagctgc ggtagttgct gtaagttcga cgaggacgac     3780

agcgagcccg tgctgaaggg cgtgaagctg cactacacgt aatag                     3825


<210>  5
<211>  3825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  213 DNA ORF

<400>  5
atgttcgtat tcctagtgct gctgcccctg gtgagcagcc agtgcgtgaa cctgaccaca       60

cgcactcagc tgccaccagc ctacaccaac tcattcacca ggggcgtgta ctatcctgac      120

aaggtgttca ggagcagcgt gctgcactcc acccaggatc tgttcctgcc cttcttcagc      180

aacgtgacat ggttccacgc catccacgtg agcgggacaa acggcaccaa gcggtttgac      240

aatcccgttc tgccattcaa cgatggcgtg tacttcgcca gcaccgagaa aagcaacatc      300

atccggggct ggatcttcgg caccacactg gacagcaaga cccagagtct gctgatcgtg      360

aacaacgcca ccaacgtggt gatcaaggtg tgtgagttcc agttctgtaa tgaccccttc      420

ctgggggtct attaccacaa gaacaataaa agctggatgg agagcgagtt tcgggtgtac      480

agtagtgcca acaactgtac attcgagtac gtgtcccagc cattcctgat ggacctggag      540

gggaagcagg ggaacttcaa gaacctgcgg gagttcgtgt ttaagaatat cgacggatat      600

tttaagatct actccaagca cacccccatc aacctggtgc gggatctgcc ccagggcttc      660

agcgccctgg agcccctggt ggacctgccc atcgggatca acatcacccg gttccagacc      720

ctgctggccc tgcaccggag ttacctgacc ccaggtgact ccagcagcgg ctggacagcc      780

ggggctgcag cctactacgt gggctacctg cagccccgga ccttcctcct gaagtacaat      840

gagaacggca ccatcaccga tgccgtggat tgtgctctgg accccctgtc tgagaccaag      900

tgcaccctga aaagcttcac cgtggagaag gggatctacc agacaagcaa ctttcgggtg      960

cagcccaccg agagtatcgt gaggttcccc aacatcacca acctgtgtcc attcggggag     1020

gtgttcaacg ccacccggtt cgcaagcgtg tacgcttgga accggaagcg catcagcaat     1080

tgcgtggctg attacagcgt gctgtacaac agcgcctcct tcagcacatt caagtgctac     1140

ggcgtctccc ccacaaagct gaacgatctg tgtttcacca acgtgtacgc agacagcttt     1200

gtgatccggg gagacgaggt gcggcagatc gcacccgggc agaccggcaa gattgctgac     1260

tacaattaca agctgcctga tgacttcaca ggctgcgtga ttgcctggaa cagcaataac     1320

ctggacagca aggtgggagg taattacaat tacctctacc ggctgttcag gaagtccaat     1380

ctgaagccct tcgagaggga catctccacc gagatctacc aggctgggtc caccccatgc     1440

aatggggtgg agggcttcaa ctgctacttc cccctgcagt cctacggctt ccagcccacc     1500

aatggggtgg gctaccagcc ctaccgggtg gtggtgctga gcttcgagct cctgcacgcc     1560

cccgccactg tgtgcggccc caagaagtcc accaacctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acgggttgac cgggactggg gtgctcacag agagcaacaa gaagttcctg     1680

cccttccagc agttcggaag ggacatcgcc gacaccacgg atgccgtgag ggatccccag     1740

accctcgaga tcctggacat cacgccatgc tccttcgggg gcgtgagcgt gatcactcct     1800

ggcacaaaca cctccaacca ggtggctgtg ctgtaccagg gcgtgaactg caccgaggtg     1860

cctgtggcca tccatgctga ccagctgacc cccacctggc gggtctacag caccggcagc     1920

aacgtgttcc agacccgggc cggctgcctg atcggggccg agcacgtgaa caacagctac     1980

gagtgcgata tccccatcgg cgccggcatc tgcgctagct accagacaca gaccaatagc     2040

ccccaatccg ctcaatctgt ggctagccag agcatcatcg cctacactat gtctctgggc     2100

gcagagaata gtgtggctta cagcaacaac agcatcgcca ttcccactaa tttcacaatt     2160

agtgtgacca ccgagatcct gcctgtgagc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gggatagcac cgagtgcagc aacctgctgc tgcagtacgg cagcttctgc     2280

acacagctga accgggccct gaccggtatc gctgtggagc aggacaagaa cacccaggag     2340

gtgtttgcgc aggtgaagca gatctacaag acccctccta tcaaggactt cgggggcttt     2400

aacttcagcc agatcctgcc agacccctcc aagccctcca agaggagctt catcgaggat     2460

ctcctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta cggagattgc     2520

ctgggcgaca tcgccgccag ggatctcatc tgcgcccaga agttcaacgg cctgaccgtg     2580

ctgccccccc tgctgaccga tgagatgatc gctcagtaca ccagcgccct gctggctggg     2640

accatcacca gcgggtggac cttcggggcc ggcgccgccc tgcagatccc cttcgccatg     2700

cagatggcct accggttcaa cggtattggg gtgacccaga atgtgctgta tgagaaccag     2760

aagctgatcg ccaaccagtt caactctgcc atcggcaaga tccaggactc cctgagcagc     2820

actgccagcg ccctgggcaa gctgcaggac gtggtgaacc agaacgccca ggccctgaat     2880

accctggtga agcagctgtc cagcaacttc ggggccatca gcagcgtgct gaacgacatc     2940

ctgtcccgcc tggacccacc agaggcagag gtgcagatcg atcggctgat cacaggtagg     3000

ctgcagagcc tgcagaccta cgtgacccag cagctgatcc gcgccgctga gattagggcc     3060

agcgccaacc tggccgccac taagatgagc gagtgcgtgc tgggccagag caagcgggtg     3120

gacttctgcg gcaaggggta tcacctgatg agcttccctc agtccgcccc ccacggggtg     3180

gtgttcctgc acgtgacata cgtgcccgcc caggagaaga acttcaccac cgcccctgcc     3240

atctgccacg atggcaaggc ccactttccc cgggagggcg tgttcgtgtc caatggcaca     3300

cattggttcg tgacccagcg gaacttctac gagccacaga tcattaccac tgacaatacc     3360

tttgtcagtg gtaactgtga cgtggtgatc ggcattgtga acaacacagt gtacgatcct     3420

ctgcagccag agctggacag cttcaaggag gagctggaca agtacttcaa gaaccacacc     3480

agccccgacg tggatcttgg agacatctct ggcatcaacg ccagcgtggt caacatccag     3540

aaggagattg accgcctgaa cgaggttgcc aagaacctga acgagagtct gatcgacctc     3600

caggagcttg gcaagtacga gcagtacatc aagtggccat ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgcat gacctcttgt     3720

tgcagctgcc tgaaggggtg ctgcagctgc ggtagttgct gtaagttcga cgaggacgac     3780

agcgagcccg tgctgaaggg cgtgaagctg cactacacgt aatag                     3825


<210>  6
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7启动子

<400>  6
taatacgact cactata                                                      17


<210>  7
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' UTR

<400>  7
aggaaattcc atttggctgc agcttctgga gggagccgac aggagacgtg gggagacggc       60

cacc                                                                    64


<210>  8
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' UTR

<400>  8
gctgccttct gcggggcttg ccttctggcc atgcccttct tctctccctt gcacctgtac       60

ctcttggtct ttgaataaag cctgagtagg aagt                                   94


<210>  9
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  poly(A)

<400>  9
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaa                                                        75


<210>  10
<211>  3825
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  212 RNA ORF

<400>  10
auguucguau uccuagugcu gcugccccug gugagcagcc agugcgugaa ccugaccaca       60

cgcacucagc ugccaccagc cuacaccaac ucauucacca ggggcgugua cuauccugac      120

aagguguuca ggagcagcgu gcugcacucc acccaggauc uguuccugcc cuucuucagc      180

aacgugacau gguuccacgc cauccacgug agcgggacaa acggcaccaa gcgguuugac      240

aaucccguuc ugccauucaa cgauggcgug uacuucgcca gcaccgagaa aagcaacauc      300

auccggggcu ggaucuucgg caccacacug gacagcaaga cccagagucu gcugaucgug      360

aacaacgcca ccaacguggu gaucaaggug ugugaguucc aguucuguaa ugaccccuuc      420

cugggggucu auuaccacaa gaacaauaaa agcuggaugg agagcgaguu ucggguguac      480

aguagugcca acaacuguac auucgaguac gugucccagc cauuccugau ggaccuggag      540

gggaagcagg ggaacuucaa gaaccugcgg gaguucgugu uuaagaauau cgacggauau      600

uuuaagaucu acuccaagca cacccccauc aaccuggugc gggaucugcc ccagggcuuc      660

agcgcccugg agccccuggu ggaccugccc aucgggauca acaucacccg guuccagacc      720

cugcuggccc ugcaccggag uuaccugacc ccaggugacu ccagcagcgg cuggacagcc      780

ggggcugcag ccuacuacgu gggcuaccug cagccccgga ccuuccuccu gaaguacaau      840

gagaacggca ccaucaccga ugccguggau ugugcucugg acccccuguc ugagaccaag      900

ugcacccuga aaagcuucac cguggagaag gggaucuacc agacaagcaa cuuucgggug      960

cagcccaccg agaguaucgu gagguucccc aacaucacca accugugucc auucggggag     1020

guguucaacg ccacccgguu cgcaagcgug uacgcuugga accggaagcg caucagcaau     1080

ugcguggcug auuacagcgu gcuguacaac agcgccuccu ucagcacauu caagugcuac     1140

ggcgucuccc ccacaaagcu gaacgaucug uguuucacca acguguacgc agacagcuuu     1200

gugauccggg gagacgaggu gcggcagauc gcacccgggc agaccggcaa gauugcugac     1260

uacaauuaca agcugccuga ugacuucaca ggcugcguga uugccuggaa cagcaauaac     1320

cuggacagca aggugggagg uaauuacaau uaccucuacc ggcuguucag gaaguccaau     1380

cugaagcccu ucgagaggga caucuccacc gagaucuacc aggcuggguc caccccaugc     1440

aauggggugg agggcuucaa cugcuacuuc ccccugcagu ccuacggcuu ccagcccacc     1500

aauggggugg gcuaccagcc cuaccgggug guggugcuga gcuucgagcu ccugcacgcc     1560

cccgccacug ugugcggccc caagaagucc accaaccugg ugaagaacaa gugcgugaac     1620

uucaacuuca acggguugac cgggacuggg gugcucacag agagcaacaa gaaguuccug     1680

cccuuccagc aguucggaag ggacaucgcc gacaccacgg augccgugag ggauccccag     1740

acccucgaga uccuggacau cacgccaugc uccuucgggg gcgugagcgu gaucacuccu     1800

ggcacaaaca ccuccaacca gguggcugug cuguaccagg gcgugaacug caccgaggug     1860

ccuguggcca uccaugcuga ccagcugacc cccaccuggc gggucuacag caccggcagc     1920

aacguguucc agacccgggc cggcugccug aucggggccg agcacgugaa caacagcuac     1980

gagugcgaua uccccaucgg cgccggcauc ugcgcuagcu accagacaca gaccaauagc     2040

cccagacggg cuaggucugu ggcuagccag agcaucaucg ccuacacuau gucucugggc     2100

gcagagaaua guguggcuua cagcaacaac agcaucgcca uucccacuaa uuucacaauu     2160

agugugacca ccgagauccu gccugugagc augaccaaga ccagcgugga cugcaccaug     2220

uacaucugcg gggauagcac cgagugcagc aaccugcugc ugcaguacgg cagcuucugc     2280

acacagcuga accgggcccu gaccgguauc gcuguggagc aggacaagaa cacccaggag     2340

guguuugcgc aggugaagca gaucuacaag accccuccua ucaaggacuu cgggggcuuu     2400

aacuucagcc agauccugcc agaccccucc aagcccucca agaggagcuu caucgaggau     2460

cuccuguuca acaaggugac ccuggccgau gccggcuuca ucaagcagua cggagauugc     2520

cugggcgaca ucgccgccag ggaucucauc ugcgcccaga aguucaacgg ccugaccgug     2580

cugccccccc ugcugaccga ugagaugauc gcucaguaca ccagcgcccu gcuggcuggg     2640

accaucacca gcggguggac cuucggggcc ggcgccgccc ugcagauccc cuucgccaug     2700

cagauggccu accgguucaa cgguauuggg gugacccaga augugcugua ugagaaccag     2760

aagcugaucg ccaaccaguu caacucugcc aucggcaaga uccaggacuc ccugagcagc     2820

acugccagcg cccugggcaa gcugcaggac guggugaacc agaacgccca ggcccugaau     2880

acccugguga agcagcuguc cagcaacuuc ggggccauca gcagcgugcu gaacgacauc     2940

cugucccgcc uggacccacc agaggcagag gugcagaucg aucggcugau cacagguagg     3000

cugcagagcc ugcagaccua cgugacccag cagcugaucc gcgccgcuga gauuagggcc     3060

agcgccaacc uggccgccac uaagaugagc gagugcgugc ugggccagag caagcgggug     3120

gacuucugcg gcaaggggua ucaccugaug agcuucccuc aguccgcccc ccacggggug     3180

guguuccugc acgugacaua cgugcccgcc caggagaaga acuucaccac cgccccugcc     3240

aucugccacg auggcaaggc ccacuuuccc cgggagggcg uguucguguc caauggcaca     3300

cauugguucg ugacccagcg gaacuucuac gagccacaga ucauuaccac ugacaauacc     3360

uuugucagug guaacuguga cguggugauc ggcauuguga acaacacagu guacgauccu     3420

cugcagccag agcuggacag cuucaaggag gagcuggaca aguacuucaa gaaccacacc     3480

agccccgacg uggaucuugg agacaucucu ggcaucaacg ccagcguggu caacauccag     3540

aaggagauug accgccugaa cgagguugcc aagaaccuga acgagagucu gaucgaccuc     3600

caggagcuug gcaaguacga gcaguacauc aaguggccau gguacaucug gcugggcuuc     3660

aucgccggcc ugaucgccau cgugauggug accaucaugc ugugcugcau gaccucuugu     3720

ugcagcugcc ugaaggggug cugcagcugc gguaguugcu guaaguucga cgaggacgac     3780

agcgagcccg ugcugaaggg cgugaagcug cacuacacgu aauag                     3825


<210>  11
<211>  3825
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  213 RNA ORF

<400>  11
auguucguau uccuagugcu gcugccccug gugagcagcc agugcgugaa ccugaccaca       60

cgcacucagc ugccaccagc cuacaccaac ucauucacca ggggcgugua cuauccugac      120

aagguguuca ggagcagcgu gcugcacucc acccaggauc uguuccugcc cuucuucagc      180

aacgugacau gguuccacgc cauccacgug agcgggacaa acggcaccaa gcgguuugac      240

aaucccguuc ugccauucaa cgauggcgug uacuucgcca gcaccgagaa aagcaacauc      300

auccggggcu ggaucuucgg caccacacug gacagcaaga cccagagucu gcugaucgug      360

aacaacgcca ccaacguggu gaucaaggug ugugaguucc aguucuguaa ugaccccuuc      420

cugggggucu auuaccacaa gaacaauaaa agcuggaugg agagcgaguu ucggguguac      480

aguagugcca acaacuguac auucgaguac gugucccagc cauuccugau ggaccuggag      540

gggaagcagg ggaacuucaa gaaccugcgg gaguucgugu uuaagaauau cgacggauau      600

uuuaagaucu acuccaagca cacccccauc aaccuggugc gggaucugcc ccagggcuuc      660

agcgcccugg agccccuggu ggaccugccc aucgggauca acaucacccg guuccagacc      720

cugcuggccc ugcaccggag uuaccugacc ccaggugacu ccagcagcgg cuggacagcc      780

ggggcugcag ccuacuacgu gggcuaccug cagccccgga ccuuccuccu gaaguacaau      840

gagaacggca ccaucaccga ugccguggau ugugcucugg acccccuguc ugagaccaag      900

ugcacccuga aaagcuucac cguggagaag gggaucuacc agacaagcaa cuuucgggug      960

cagcccaccg agaguaucgu gagguucccc aacaucacca accugugucc auucggggag     1020

guguucaacg ccacccgguu cgcaagcgug uacgcuugga accggaagcg caucagcaau     1080

ugcguggcug auuacagcgu gcuguacaac agcgccuccu ucagcacauu caagugcuac     1140

ggcgucuccc ccacaaagcu gaacgaucug uguuucacca acguguacgc agacagcuuu     1200

gugauccggg gagacgaggu gcggcagauc gcacccgggc agaccggcaa gauugcugac     1260

uacaauuaca agcugccuga ugacuucaca ggcugcguga uugccuggaa cagcaauaac     1320

cuggacagca aggugggagg uaauuacaau uaccucuacc ggcuguucag gaaguccaau     1380

cugaagcccu ucgagaggga caucuccacc gagaucuacc aggcuggguc caccccaugc     1440

aauggggugg agggcuucaa cugcuacuuc ccccugcagu ccuacggcuu ccagcccacc     1500

aauggggugg gcuaccagcc cuaccgggug guggugcuga gcuucgagcu ccugcacgcc     1560

cccgccacug ugugcggccc caagaagucc accaaccugg ugaagaacaa gugcgugaac     1620

uucaacuuca acggguugac cgggacuggg gugcucacag agagcaacaa gaaguuccug     1680

cccuuccagc aguucggaag ggacaucgcc gacaccacgg augccgugag ggauccccag     1740

acccucgaga uccuggacau cacgccaugc uccuucgggg gcgugagcgu gaucacuccu     1800

ggcacaaaca ccuccaacca gguggcugug cuguaccagg gcgugaacug caccgaggug     1860

ccuguggcca uccaugcuga ccagcugacc cccaccuggc gggucuacag caccggcagc     1920

aacguguucc agacccgggc cggcugccug aucggggccg agcacgugaa caacagcuac     1980

gagugcgaua uccccaucgg cgccggcauc ugcgcuagcu accagacaca gaccaauagc     2040

ccccaauccg cucaaucugu ggcuagccag agcaucaucg ccuacacuau gucucugggc     2100

gcagagaaua guguggcuua cagcaacaac agcaucgcca uucccacuaa uuucacaauu     2160

agugugacca ccgagauccu gccugugagc augaccaaga ccagcgugga cugcaccaug     2220

uacaucugcg gggauagcac cgagugcagc aaccugcugc ugcaguacgg cagcuucugc     2280

acacagcuga accgggcccu gaccgguauc gcuguggagc aggacaagaa cacccaggag     2340

guguuugcgc aggugaagca gaucuacaag accccuccua ucaaggacuu cgggggcuuu     2400

aacuucagcc agauccugcc agaccccucc aagcccucca agaggagcuu caucgaggau     2460

cuccuguuca acaaggugac ccuggccgau gccggcuuca ucaagcagua cggagauugc     2520

cugggcgaca ucgccgccag ggaucucauc ugcgcccaga aguucaacgg ccugaccgug     2580

cugccccccc ugcugaccga ugagaugauc gcucaguaca ccagcgcccu gcuggcuggg     2640

accaucacca gcggguggac cuucggggcc ggcgccgccc ugcagauccc cuucgccaug     2700

cagauggccu accgguucaa cgguauuggg gugacccaga augugcugua ugagaaccag     2760

aagcugaucg ccaaccaguu caacucugcc aucggcaaga uccaggacuc ccugagcagc     2820

acugccagcg cccugggcaa gcugcaggac guggugaacc agaacgccca ggcccugaau     2880

acccugguga agcagcuguc cagcaacuuc ggggccauca gcagcgugcu gaacgacauc     2940

cugucccgcc uggacccacc agaggcagag gugcagaucg aucggcugau cacagguagg     3000

cugcagagcc ugcagaccua cgugacccag cagcugaucc gcgccgcuga gauuagggcc     3060

agcgccaacc uggccgccac uaagaugagc gagugcgugc ugggccagag caagcgggug     3120

gacuucugcg gcaaggggua ucaccugaug agcuucccuc aguccgcccc ccacggggug     3180

guguuccugc acgugacaua cgugcccgcc caggagaaga acuucaccac cgccccugcc     3240

aucugccacg auggcaaggc ccacuuuccc cgggagggcg uguucguguc caauggcaca     3300

cauugguucg ugacccagcg gaacuucuac gagccacaga ucauuaccac ugacaauacc     3360

uuugucagug guaacuguga cguggugauc ggcauuguga acaacacagu guacgauccu     3420

cugcagccag agcuggacag cuucaaggag gagcuggaca aguacuucaa gaaccacacc     3480

agccccgacg uggaucuugg agacaucucu ggcaucaacg ccagcguggu caacauccag     3540

aaggagauug accgccugaa cgagguugcc aagaaccuga acgagagucu gaucgaccuc     3600

caggagcuug gcaaguacga gcaguacauc aaguggccau gguacaucug gcugggcuuc     3660

aucgccggcc ugaucgccau cgugauggug accaucaugc ugugcugcau gaccucuugu     3720

ugcagcugcc ugaaggggug cugcagcugc gguaguugcu guaaguucga cgaggacgac     3780

agcgagcccg ugcugaaggg cgugaagcug cacuacacgu aauag                     3825


<210>  12
<211>  4058
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  212 mRNA

<400>  12
aggaaauucc auuuggcugc agcuucugga gggagccgac aggagacgug gggagacggc       60

caccauguuc guauuccuag ugcugcugcc ccuggugagc agccagugcg ugaaccugac      120

cacacgcacu cagcugccac cagccuacac caacucauuc accaggggcg uguacuaucc      180

ugacaaggug uucaggagca gcgugcugca cuccacccag gaucuguucc ugcccuucuu      240

cagcaacgug acaugguucc acgccaucca cgugagcggg acaaacggca ccaagcgguu      300

ugacaauccc guucugccau ucaacgaugg cguguacuuc gccagcaccg agaaaagcaa      360

caucauccgg ggcuggaucu ucggcaccac acuggacagc aagacccaga gucugcugau      420

cgugaacaac gccaccaacg uggugaucaa ggugugugag uuccaguucu guaaugaccc      480

cuuccugggg gucuauuacc acaagaacaa uaaaagcugg auggagagcg aguuucgggu      540

guacaguagu gccaacaacu guacauucga guacgugucc cagccauucc ugauggaccu      600

ggaggggaag caggggaacu ucaagaaccu gcgggaguuc guguuuaaga auaucgacgg      660

auauuuuaag aucuacucca agcacacccc caucaaccug gugcgggauc ugccccaggg      720

cuucagcgcc cuggagcccc ugguggaccu gcccaucggg aucaacauca cccgguucca      780

gacccugcug gcccugcacc ggaguuaccu gaccccaggu gacuccagca gcggcuggac      840

agccggggcu gcagccuacu acgugggcua ccugcagccc cggaccuucc uccugaagua      900

caaugagaac ggcaccauca ccgaugccgu ggauugugcu cuggaccccc ugucugagac      960

caagugcacc cugaaaagcu ucaccgugga gaaggggauc uaccagacaa gcaacuuucg     1020

ggugcagccc accgagagua ucgugagguu ccccaacauc accaaccugu guccauucgg     1080

ggagguguuc aacgccaccc gguucgcaag cguguacgcu uggaaccgga agcgcaucag     1140

caauugcgug gcugauuaca gcgugcugua caacagcgcc uccuucagca cauucaagug     1200

cuacggcguc ucccccacaa agcugaacga ucuguguuuc accaacgugu acgcagacag     1260

cuuugugauc cggggagacg aggugcggca gaucgcaccc gggcagaccg gcaagauugc     1320

ugacuacaau uacaagcugc cugaugacuu cacaggcugc gugauugccu ggaacagcaa     1380

uaaccuggac agcaaggugg gagguaauua caauuaccuc uaccggcugu ucaggaaguc     1440

caaucugaag cccuucgaga gggacaucuc caccgagauc uaccaggcug gguccacccc     1500

augcaauggg guggagggcu ucaacugcua cuucccccug caguccuacg gcuuccagcc     1560

caccaauggg gugggcuacc agcccuaccg ggugguggug cugagcuucg agcuccugca     1620

cgcccccgcc acugugugcg gccccaagaa guccaccaac cuggugaaga acaagugcgu     1680

gaacuucaac uucaacgggu ugaccgggac uggggugcuc acagagagca acaagaaguu     1740

ccugcccuuc cagcaguucg gaagggacau cgccgacacc acggaugccg ugagggaucc     1800

ccagacccuc gagauccugg acaucacgcc augcuccuuc gggggcguga gcgugaucac     1860

uccuggcaca aacaccucca accagguggc ugugcuguac cagggcguga acugcaccga     1920

ggugccugug gccauccaug cugaccagcu gacccccacc uggcgggucu acagcaccgg     1980

cagcaacgug uuccagaccc gggccggcug ccugaucggg gccgagcacg ugaacaacag     2040

cuacgagugc gauaucccca ucggcgccgg caucugcgcu agcuaccaga cacagaccaa     2100

uagccccaga cgggcuaggu cuguggcuag ccagagcauc aucgccuaca cuaugucucu     2160

gggcgcagag aauagugugg cuuacagcaa caacagcauc gccauuccca cuaauuucac     2220

aauuagugug accaccgaga uccugccugu gagcaugacc aagaccagcg uggacugcac     2280

cauguacauc ugcggggaua gcaccgagug cagcaaccug cugcugcagu acggcagcuu     2340

cugcacacag cugaaccggg cccugaccgg uaucgcugug gagcaggaca agaacaccca     2400

ggagguguuu gcgcagguga agcagaucua caagaccccu ccuaucaagg acuucggggg     2460

cuuuaacuuc agccagaucc ugccagaccc cuccaagccc uccaagagga gcuucaucga     2520

ggaucuccug uucaacaagg ugacccuggc cgaugccggc uucaucaagc aguacggaga     2580

uugccugggc gacaucgccg ccagggaucu caucugcgcc cagaaguuca acggccugac     2640

cgugcugccc ccccugcuga ccgaugagau gaucgcucag uacaccagcg cccugcuggc     2700

ugggaccauc accagcgggu ggaccuucgg ggccggcgcc gcccugcaga uccccuucgc     2760

caugcagaug gccuaccggu ucaacgguau uggggugacc cagaaugugc uguaugagaa     2820

ccagaagcug aucgccaacc aguucaacuc ugccaucggc aagauccagg acucccugag     2880

cagcacugcc agcgcccugg gcaagcugca ggacguggug aaccagaacg cccaggcccu     2940

gaauacccug gugaagcagc uguccagcaa cuucggggcc aucagcagcg ugcugaacga     3000

cauccugucc cgccuggacc caccagaggc agaggugcag aucgaucggc ugaucacagg     3060

uaggcugcag agccugcaga ccuacgugac ccagcagcug auccgcgccg cugagauuag     3120

ggccagcgcc aaccuggccg ccacuaagau gagcgagugc gugcugggcc agagcaagcg     3180

gguggacuuc ugcggcaagg gguaucaccu gaugagcuuc ccucaguccg ccccccacgg     3240

ggugguguuc cugcacguga cauacgugcc cgcccaggag aagaacuuca ccaccgcccc     3300

ugccaucugc cacgauggca aggcccacuu uccccgggag ggcguguucg uguccaaugg     3360

cacacauugg uucgugaccc agcggaacuu cuacgagcca cagaucauua ccacugacaa     3420

uaccuuuguc agugguaacu gugacguggu gaucggcauu gugaacaaca caguguacga     3480

uccucugcag ccagagcugg acagcuucaa ggaggagcug gacaaguacu ucaagaacca     3540

caccagcccc gacguggauc uuggagacau cucuggcauc aacgccagcg uggucaacau     3600

ccagaaggag auugaccgcc ugaacgaggu ugccaagaac cugaacgaga gucugaucga     3660

ccuccaggag cuuggcaagu acgagcagua caucaagugg ccaugguaca ucuggcuggg     3720

cuucaucgcc ggccugaucg ccaucgugau ggugaccauc augcugugcu gcaugaccuc     3780

uuguugcagc ugccugaagg ggugcugcag cugcgguagu ugcuguaagu ucgacgagga     3840

cgacagcgag cccgugcuga agggcgugaa gcugcacuac acguaauagg cugccuucug     3900

cggggcuugc cuucuggcca ugcccuucuu cucucccuug caccuguacc ucuuggucuu     3960

ugaauaaagc cugaguagga aguaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             4058


<210>  13
<211>  4058
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  213 mRNA

<400>  13
aggaaauucc auuuggcugc agcuucugga gggagccgac aggagacgug gggagacggc       60

caccauguuc guauuccuag ugcugcugcc ccuggugagc agccagugcg ugaaccugac      120

cacacgcacu cagcugccac cagccuacac caacucauuc accaggggcg uguacuaucc      180

ugacaaggug uucaggagca gcgugcugca cuccacccag gaucuguucc ugcccuucuu      240

cagcaacgug acaugguucc acgccaucca cgugagcggg acaaacggca ccaagcgguu      300

ugacaauccc guucugccau ucaacgaugg cguguacuuc gccagcaccg agaaaagcaa      360

caucauccgg ggcuggaucu ucggcaccac acuggacagc aagacccaga gucugcugau      420

cgugaacaac gccaccaacg uggugaucaa ggugugugag uuccaguucu guaaugaccc      480

cuuccugggg gucuauuacc acaagaacaa uaaaagcugg auggagagcg aguuucgggu      540

guacaguagu gccaacaacu guacauucga guacgugucc cagccauucc ugauggaccu      600

ggaggggaag caggggaacu ucaagaaccu gcgggaguuc guguuuaaga auaucgacgg      660

auauuuuaag aucuacucca agcacacccc caucaaccug gugcgggauc ugccccaggg      720

cuucagcgcc cuggagcccc ugguggaccu gcccaucggg aucaacauca cccgguucca      780

gacccugcug gcccugcacc ggaguuaccu gaccccaggu gacuccagca gcggcuggac      840

agccggggcu gcagccuacu acgugggcua ccugcagccc cggaccuucc uccugaagua      900

caaugagaac ggcaccauca ccgaugccgu ggauugugcu cuggaccccc ugucugagac      960

caagugcacc cugaaaagcu ucaccgugga gaaggggauc uaccagacaa gcaacuuucg     1020

ggugcagccc accgagagua ucgugagguu ccccaacauc accaaccugu guccauucgg     1080

ggagguguuc aacgccaccc gguucgcaag cguguacgcu uggaaccgga agcgcaucag     1140

caauugcgug gcugauuaca gcgugcugua caacagcgcc uccuucagca cauucaagug     1200

cuacggcguc ucccccacaa agcugaacga ucuguguuuc accaacgugu acgcagacag     1260

cuuugugauc cggggagacg aggugcggca gaucgcaccc gggcagaccg gcaagauugc     1320

ugacuacaau uacaagcugc cugaugacuu cacaggcugc gugauugccu ggaacagcaa     1380

uaaccuggac agcaaggugg gagguaauua caauuaccuc uaccggcugu ucaggaaguc     1440

caaucugaag cccuucgaga gggacaucuc caccgagauc uaccaggcug gguccacccc     1500

augcaauggg guggagggcu ucaacugcua cuucccccug caguccuacg gcuuccagcc     1560

caccaauggg gugggcuacc agcccuaccg ggugguggug cugagcuucg agcuccugca     1620

cgcccccgcc acugugugcg gccccaagaa guccaccaac cuggugaaga acaagugcgu     1680

gaacuucaac uucaacgggu ugaccgggac uggggugcuc acagagagca acaagaaguu     1740

ccugcccuuc cagcaguucg gaagggacau cgccgacacc acggaugccg ugagggaucc     1800

ccagacccuc gagauccugg acaucacgcc augcuccuuc gggggcguga gcgugaucac     1860

uccuggcaca aacaccucca accagguggc ugugcuguac cagggcguga acugcaccga     1920

ggugccugug gccauccaug cugaccagcu gacccccacc uggcgggucu acagcaccgg     1980

cagcaacgug uuccagaccc gggccggcug ccugaucggg gccgagcacg ugaacaacag     2040

cuacgagugc gauaucccca ucggcgccgg caucugcgcu agcuaccaga cacagaccaa     2100

uagcccccaa uccgcucaau cuguggcuag ccagagcauc aucgccuaca cuaugucucu     2160

gggcgcagag aauagugugg cuuacagcaa caacagcauc gccauuccca cuaauuucac     2220

aauuagugug accaccgaga uccugccugu gagcaugacc aagaccagcg uggacugcac     2280

cauguacauc ugcggggaua gcaccgagug cagcaaccug cugcugcagu acggcagcuu     2340

cugcacacag cugaaccggg cccugaccgg uaucgcugug gagcaggaca agaacaccca     2400

ggagguguuu gcgcagguga agcagaucua caagaccccu ccuaucaagg acuucggggg     2460

cuuuaacuuc agccagaucc ugccagaccc cuccaagccc uccaagagga gcuucaucga     2520

ggaucuccug uucaacaagg ugacccuggc cgaugccggc uucaucaagc aguacggaga     2580

uugccugggc gacaucgccg ccagggaucu caucugcgcc cagaaguuca acggccugac     2640

cgugcugccc ccccugcuga ccgaugagau gaucgcucag uacaccagcg cccugcuggc     2700

ugggaccauc accagcgggu ggaccuucgg ggccggcgcc gcccugcaga uccccuucgc     2760

caugcagaug gccuaccggu ucaacgguau uggggugacc cagaaugugc uguaugagaa     2820

ccagaagcug aucgccaacc aguucaacuc ugccaucggc aagauccagg acucccugag     2880

cagcacugcc agcgcccugg gcaagcugca ggacguggug aaccagaacg cccaggcccu     2940

gaauacccug gugaagcagc uguccagcaa cuucggggcc aucagcagcg ugcugaacga     3000

cauccugucc cgccuggacc caccagaggc agaggugcag aucgaucggc ugaucacagg     3060

uaggcugcag agccugcaga ccuacgugac ccagcagcug auccgcgccg cugagauuag     3120

ggccagcgcc aaccuggccg ccacuaagau gagcgagugc gugcugggcc agagcaagcg     3180

gguggacuuc ugcggcaagg gguaucaccu gaugagcuuc ccucaguccg ccccccacgg     3240

ggugguguuc cugcacguga cauacgugcc cgcccaggag aagaacuuca ccaccgcccc     3300

ugccaucugc cacgauggca aggcccacuu uccccgggag ggcguguucg uguccaaugg     3360

cacacauugg uucgugaccc agcggaacuu cuacgagcca cagaucauua ccacugacaa     3420

uaccuuuguc agugguaacu gugacguggu gaucggcauu gugaacaaca caguguacga     3480

uccucugcag ccagagcugg acagcuucaa ggaggagcug gacaaguacu ucaagaacca     3540

caccagcccc gacguggauc uuggagacau cucuggcauc aacgccagcg uggucaacau     3600

ccagaaggag auugaccgcc ugaacgaggu ugccaagaac cugaacgaga gucugaucga     3660

ccuccaggag cuuggcaagu acgagcagua caucaagugg ccaugguaca ucuggcuggg     3720

cuucaucgcc ggccugaucg ccaucgugau ggugaccauc augcugugcu gcaugaccuc     3780

uuguugcagc ugccugaagg ggugcugcag cugcgguagu ugcuguaagu ucgacgagga     3840

cgacagcgag cccgugcuga agggcgugaa gcugcacuac acguaauagg cugccuucug     3900

cggggcuugc cuucuggcca ugcccuucuu cucucccuug caccuguacc ucuuggucuu     3960

ugaauaaagc cugaguagga aguaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             4058


