                         SEQUENCE LISTING

<110>  Ottawa Hospital Research Institute
 
<120>  EXTRACELLULAR VESICLE-DIRECTED POLYPEPTIDE TAG

<130>  PAT 110421W-90

<140>  Not yet filed
<141>  2022-05-03

<150>  US 63/183,902
<151>  2021-05-04

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-Wnt2

<400>  1

Met Asn Ala Pro Leu Gly Gly Ile Trp Leu Trp Leu Pro Leu Leu Leu 
1               5                   10                  15      


Thr Trp Leu Thr Pro Glu Val Asn Ser Ser Trp Trp Tyr Met Arg Ala 
            20                  25                  30          


Thr Gly Gly Ser Ser Arg Val Met Cys Asp Asn Val Pro Gly Leu Val 
        35                  40                  45              


Ser Ser Gln Arg Gln Leu Cys His Arg His Pro Asp Val Met Arg Ala 
    50                  55                  60                  


Ile Ser Gln Gly Val Ala Glu Trp Thr Ala Glu Cys Gln His Gln Phe 
65                  70                  75                  80  


Arg Gln His Arg Trp Asn Cys Asn Thr Leu Asp Arg Asp His Ser Leu 
                85                  90                  95      


Phe Gly Arg Val Leu Leu Arg Ser Ser Arg Glu Ser Ala Phe Val Tyr 
            100                 105                 110         


Ala Ile Ser Ser Ala Gly Val Val Phe Ala Ile Thr Arg Ala Cys Ser 
        115                 120                 125             


Gln Gly Glu Val Lys Ser Cys Ser Cys Asp Pro Lys Lys Met Gly Ser 
    130                 135                 140                 


Ala Lys Asp Ser Lys Gly Ile Phe Asp Trp Gly Gly Cys Ser Asp Asn 
145                 150                 155                 160 


Ile Asp Tyr Gly Ile Lys Phe Ala Arg Ala Phe Val Asp Ala Lys Glu 
                165                 170                 175     


Arg Lys Gly Lys Asp Ala Arg Ala Leu Met Asn Leu His Asn Asn Arg 
            180                 185                 190         


Ala Gly Arg Lys Ala Val Lys Arg Phe Leu Lys Gln Glu Cys Lys Cys 
        195                 200                 205             


His Gly Val Ser Gly Ser Cys Thr Leu Arg Thr Cys Trp Leu Ala Met 
    210                 215                 220                 


Ala Asp Phe Arg Lys Thr Gly Asp Tyr Leu Trp Arg Lys Tyr Asn Gly 
225                 230                 235                 240 


Ala Ile Gln Val Val Met Asn Gln Asp Gly Thr Gly Phe Thr Val Ala 
                245                 250                 255     


Asn Glu Arg Phe Lys Lys Pro Thr Lys Asn Asp Leu Val Tyr Phe Glu 
            260                 265                 270         


Asn Ser Pro Asp Tyr Cys Ile Arg Asp Arg Glu Ala Gly Ser Leu Gly 
        275                 280                 285             


Thr Ala Gly Arg Val Cys Asn Leu Thr Ser Arg Gly Met Asp Ser Cys 
    290                 295                 300                 


Glu Val Met Cys Cys Gly Arg Gly Tyr Asp Thr Ser His Val Thr Arg 
305                 310                 315                 320 


Met Thr Lys Cys Gly Cys Lys Phe His Trp Cys Cys Ala Val Arg Cys 
                325                 330                 335     


Gln Asp Cys Leu Glu Ala Leu Asp Val His Thr Cys Lys Ala Pro Lys 
            340                 345                 350         


Asn Ala Asp Trp Thr Thr Ala Thr 
        355                 360 


<210>  2
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-Wnt2b

<400>  2

Met Leu Arg Pro Gly Gly Ala Glu Glu Ala Ala Gln Leu Pro Leu Arg 
1               5                   10                  15      


Arg Ala Ser Ala Pro Val Pro Val Pro Ser Pro Ala Ala Pro Asp Gly 
            20                  25                  30          


Ser Arg Ala Ser Ala Arg Leu Gly Leu Ala Cys Leu Leu Leu Leu Leu 
        35                  40                  45              


Leu Leu Thr Leu Pro Ala Arg Val Asp Thr Ser Trp Trp Tyr Ile Gly 
    50                  55                  60                  


Ala Leu Gly Ala Arg Val Ile Cys Asp Asn Ile Pro Gly Leu Val Ser 
65                  70                  75                  80  


Arg Gln Arg Gln Leu Cys Gln Arg Tyr Pro Asp Ile Met Arg Ser Val 
                85                  90                  95      


Gly Glu Gly Ala Arg Glu Trp Ile Arg Glu Cys Gln His Gln Phe Arg 
            100                 105                 110         


His His Arg Trp Asn Cys Thr Thr Leu Asp Arg Asp His Thr Val Phe 
        115                 120                 125             


Gly Arg Val Met Leu Arg Ser Ser Arg Glu Ala Ala Phe Val Tyr Ala 
    130                 135                 140                 


Ile Ser Ser Ala Gly Val Val His Ala Ile Thr Arg Ala Cys Ser Gln 
145                 150                 155                 160 


Gly Glu Leu Ser Val Cys Ser Cys Asp Pro Tyr Thr Arg Gly Arg His 
                165                 170                 175     


His Asp Gln Arg Gly Asp Phe Asp Trp Gly Gly Cys Ser Asp Asn Ile 
            180                 185                 190         


His Tyr Gly Val Arg Phe Ala Lys Ala Phe Val Asp Ala Lys Glu Lys 
        195                 200                 205             


Arg Leu Lys Asp Ala Arg Ala Leu Met Asn Leu His Asn Asn Arg Cys 
    210                 215                 220                 


Gly Arg Thr Ala Val Arg Arg Phe Leu Lys Leu Glu Cys Lys Cys His 
225                 230                 235                 240 


Gly Val Ser Gly Ser Cys Thr Leu Arg Thr Cys Trp Arg Ala Leu Ser 
                245                 250                 255     


Asp Phe Arg Arg Thr Gly Asp Tyr Leu Arg Arg Arg Tyr Asp Gly Ala 
            260                 265                 270         


Val Gln Val Met Ala Thr Gln Asp Gly Ala Asn Phe Thr Ala Ala Arg 
        275                 280                 285             


Gln Gly Tyr Arg Arg Ala Thr Arg Thr Asp Leu Val Tyr Phe Asp Asn 
    290                 295                 300                 


Ser Pro Asp Tyr Cys Val Leu Asp Lys Ala Ala Gly Ser Leu Gly Thr 
305                 310                 315                 320 


Ala Gly Arg Val Cys Ser Lys Thr Ser Lys Gly Thr Asp Gly Cys Glu 
                325                 330                 335     


Ile Met Cys Cys Gly Arg Gly Tyr Asp Thr Thr Arg Val Thr Arg Val 
            340                 345                 350         


Thr Gln Cys Glu Cys Lys Phe His Trp Cys Cys Ala Val Arg Cys Lys 
        355                 360                 365             


Glu Cys Arg Asn Thr Val Asp Val His Thr Cys Lys Ala Pro Lys Lys 
    370                 375                 380                 


Ala Glu Trp Leu Asp Gln Thr 
385                 390     


<210>  3
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-Wnt4

<400>  3

Met Ser Pro Arg Ser Cys Leu Arg Ser Leu Arg Leu Leu Val Phe Ala 
1               5                   10                  15      


Val Phe Ser Ala Ala Ala Ser Asn Trp Leu Tyr Leu Ala Lys Leu Ser 
            20                  25                  30          


Ser Val Gly Ser Ile Ser Glu Glu Glu Thr Cys Glu Lys Leu Lys Gly 
        35                  40                  45              


Leu Ile Gln Arg Gln Val Gln Met Cys Lys Arg Asn Leu Glu Val Met 
    50                  55                  60                  


Asp Ser Val Arg Arg Gly Ala Gln Leu Ala Ile Glu Glu Cys Gln Tyr 
65                  70                  75                  80  


Gln Phe Arg Asn Arg Arg Trp Asn Cys Ser Thr Leu Asp Ser Leu Pro 
                85                  90                  95      


Val Phe Gly Lys Val Val Thr Gln Gly Thr Arg Glu Ala Ala Phe Val 
            100                 105                 110         


Tyr Ala Ile Ser Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ala Cys 
        115                 120                 125             


Ser Ser Gly Glu Leu Glu Lys Cys Gly Cys Asp Arg Thr Val His Gly 
    130                 135                 140                 


Val Ser Pro Gln Gly Phe Gln Trp Ser Gly Cys Ser Asp Asn Ile Ala 
145                 150                 155                 160 


Tyr Gly Val Ala Phe Ser Gln Ser Phe Val Asp Val Arg Glu Arg Ser 
                165                 170                 175     


Lys Gly Ala Ser Ser Ser Arg Ala Leu Met Asn Leu His Asn Asn Glu 
            180                 185                 190         


Ala Gly Arg Lys Ala Ile Leu Thr His Met Arg Val Glu Cys Lys Cys 
        195                 200                 205             


His Gly Val Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Arg Ala Val 
    210                 215                 220                 


Pro Pro Phe Arg Gln Val Gly His Ala Leu Lys Glu Lys Phe Asp Gly 
225                 230                 235                 240 


Ala Thr Glu Val Glu Pro Arg Arg Val Gly Ser Ser Arg Ala Leu Val 
                245                 250                 255     


Pro Arg Asn Ala Gln Phe Lys Pro His Thr Asp Glu Asp Leu Val Tyr 
            260                 265                 270         


Leu Glu Pro Ser Pro Asp Phe Cys Glu Gln Asp Met Arg Ser Gly Val 
        275                 280                 285             


Leu Gly Thr Arg Gly Arg Thr Cys Asn Lys Thr Ser Lys Ala Ile Asp 
    290                 295                 300                 


Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly Phe His Thr Ala Gln Val 
305                 310                 315                 320 


Glu Leu Ala Glu Arg Cys Ser Cys Lys Phe His Trp Cys Cys Phe Val 
                325                 330                 335     


Lys Cys Arg Gln Cys Gln Arg Leu Val Glu Leu His Thr Cys Arg 
            340                 345                 350     


<210>  4
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-Wnt5b

<400>  4

Met Pro Ser Leu Leu Leu Leu Phe Thr Ala Ala Leu Leu Ser Ser Trp 
1               5                   10                  15      


Ala Gln Leu Leu Thr Asp Ala Asn Ser Trp Trp Ser Leu Ala Leu Asn 
            20                  25                  30          


Pro Val Gln Arg Pro Glu Met Phe Ile Ile Gly Ala Gln Pro Val Cys 
        35                  40                  45              


Ser Gln Leu Pro Gly Leu Ser Pro Gly Gln Arg Lys Leu Cys Gln Leu 
    50                  55                  60                  


Tyr Gln Glu His Met Ala Tyr Ile Gly Glu Gly Ala Lys Thr Gly Ile 
65                  70                  75                  80  


Lys Glu Cys Gln His Gln Phe Arg Gln Arg Arg Trp Asn Cys Ser Thr 
                85                  90                  95      


Ala Asp Asn Ala Ser Val Phe Gly Arg Val Met Gln Ile Gly Ser Arg 
            100                 105                 110         


Glu Thr Ala Phe Thr His Ala Val Ser Ala Ala Gly Val Val Asn Ala 
        115                 120                 125             


Ile Ser Arg Ala Cys Arg Glu Gly Glu Leu Ser Thr Cys Gly Cys Ser 
    130                 135                 140                 


Arg Thr Ala Arg Pro Lys Asp Leu Pro Arg Asp Trp Leu Trp Gly Gly 
145                 150                 155                 160 


Cys Gly Asp Asn Val Glu Tyr Gly Tyr Arg Phe Ala Lys Glu Phe Val 
                165                 170                 175     


Asp Ala Arg Glu Arg Glu Lys Asn Phe Ala Lys Gly Ser Glu Glu Gln 
            180                 185                 190         


Gly Arg Val Leu Met Asn Leu Gln Asn Asn Glu Ala Gly Arg Arg Ala 
        195                 200                 205             


Val Tyr Lys Met Ala Asp Val Ala Cys Lys Cys His Gly Val Ser Gly 
    210                 215                 220                 


Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln Leu Ala Glu Phe Arg Lys 
225                 230                 235                 240 


Val Gly Asp Arg Leu Lys Glu Lys Tyr Asp Ser Ala Ala Ala Met Arg 
                245                 250                 255     


Val Thr Arg Lys Gly Arg Leu Glu Leu Val Asn Ser Arg Phe Thr Gln 
            260                 265                 270         


Pro Thr Pro Glu Asp Leu Val Tyr Val Asp Pro Ser Pro Asp Tyr Cys 
        275                 280                 285             


Leu Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr Gln Gly Arg Leu Cys 
    290                 295                 300                 


Asn Lys Thr Ser Glu Gly Met Asp Gly Cys Glu Leu Met Cys Cys Gly 
305                 310                 315                 320 


Arg Gly Tyr Asn Gln Phe Lys Ser Val Gln Val Glu Arg Cys His Cys 
                325                 330                 335     


Lys Phe His Trp Cys Cys Phe Val Arg Cys Lys Lys Cys Thr Glu Ile 
            340                 345                 350         


Val Asp Gln Tyr Ile Cys Lys 
        355                 


<210>  5
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-Wnt7a

<400>  5

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys 
            340                 345                 


<210>  6
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-Wnt8a

<400>  6

Met Gly Asn Leu Phe Met Leu Trp Ala Ala Leu Gly Ile Cys Cys Ala 
1               5                   10                  15      


Ala Phe Ser Ala Ser Ala Trp Ser Val Asn Asn Phe Leu Ile Thr Gly 
            20                  25                  30          


Pro Lys Ala Tyr Leu Thr Tyr Thr Thr Ser Val Ala Leu Gly Ala Gln 
        35                  40                  45              


Ser Gly Ile Glu Glu Cys Lys Phe Gln Phe Ala Trp Glu Arg Trp Asn 
    50                  55                  60                  


Cys Pro Glu Asn Ala Leu Gln Leu Ser Thr His Asn Arg Leu Arg Ser 
65                  70                  75                  80  


Ala Thr Arg Glu Thr Ser Phe Ile His Ala Ile Ser Ser Ala Gly Val 
                85                  90                  95      


Met Tyr Ile Ile Thr Lys Asn Cys Ser Met Gly Asp Phe Glu Asn Cys 
            100                 105                 110         


Gly Cys Asp Gly Ser Asn Asn Gly Lys Thr Gly Gly His Gly Trp Ile 
        115                 120                 125             


Trp Gly Gly Cys Ser Asp Asn Val Glu Phe Gly Glu Arg Ile Ser Lys 
    130                 135                 140                 


Leu Phe Val Asp Ser Leu Glu Lys Gly Lys Asp Ala Arg Ala Leu Met 
145                 150                 155                 160 


Asn Leu His Asn Asn Arg Ala Gly Arg Leu Ala Val Arg Ala Thr Met 
                165                 170                 175     


Lys Arg Thr Cys Lys Cys His Gly Ile Ser Gly Ser Cys Ser Ile Gln 
            180                 185                 190         


Thr Cys Trp Leu Gln Leu Ala Glu Phe Arg Glu Met Gly Asp Tyr Leu 
        195                 200                 205             


Lys Ala Lys Tyr Asp Gln Ala Leu Lys Ile Glu Met Asp Lys Arg Gln 
    210                 215                 220                 


Leu Arg Ala Gly Asn Ser Ala Glu Gly His Trp Val Pro Ala Glu Ala 
225                 230                 235                 240 


Phe Leu Pro Ser Ala Glu Ala Glu Leu Ile Phe Leu Glu Glu Ser Pro 
                245                 250                 255     


Asp Tyr Cys Thr Cys Asn Ser Ser Leu Gly Ile Tyr Gly Thr Glu Gly 
            260                 265                 270         


Arg Glu Cys Leu Gln Asn Ser His Asn Thr Ser Arg Trp Glu Arg Arg 
        275                 280                 285             


Ser Cys Gly Arg Leu Cys Thr Glu Cys Gly Leu Gln Val Glu Glu Arg 
    290                 295                 300                 


Lys Thr Glu Val Ile Ser Ser Cys Asn Cys Lys Phe Gln Trp Cys Cys 
305                 310                 315                 320 


Thr Val Lys Cys Asp Gln Cys Arg His Val Val Ser Lys Tyr Tyr Cys 
                325                 330                 335     


Ala Arg Ser Pro Gly Ser Ala Gln Ser Leu Gly Lys Gly Ser Ala 
            340                 345                 350     


<210>  7
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-Wnt10a

<400>  7

Met Gly Ser Ala His Pro Arg Pro Trp Leu Arg Leu Arg Pro Gln Pro 
1               5                   10                  15      


Gln Pro Arg Pro Ala Leu Trp Val Leu Leu Phe Phe Leu Leu Leu Leu 
            20                  25                  30          


Ala Ala Ala Met Pro Arg Ser Ala Pro Asn Asp Ile Leu Asp Leu Arg 
        35                  40                  45              


Leu Pro Pro Glu Pro Val Leu Asn Ala Asn Thr Val Cys Leu Thr Leu 
    50                  55                  60                  


Pro Gly Leu Ser Arg Arg Gln Met Glu Val Cys Val Arg His Pro Asp 
65                  70                  75                  80  


Val Ala Ala Ser Ala Ile Gln Gly Ile Gln Ile Ala Ile His Glu Cys 
                85                  90                  95      


Gln His Gln Phe Arg Asp Gln Arg Trp Asn Cys Ser Ser Leu Glu Thr 
            100                 105                 110         


Arg Asn Lys Ile Pro Tyr Glu Ser Pro Ile Phe Ser Arg Gly Phe Arg 
        115                 120                 125             


Glu Ser Ala Phe Ala Tyr Ala Ile Ala Ala Ala Gly Val Val His Ala 
    130                 135                 140                 


Val Ser Asn Ala Cys Ala Leu Gly Lys Leu Lys Ala Cys Gly Cys Asp 
145                 150                 155                 160 


Ala Ser Arg Arg Gly Asp Glu Glu Ala Phe Arg Arg Lys Leu His Arg 
                165                 170                 175     


Leu Gln Leu Asp Ala Leu Gln Arg Gly Lys Gly Leu Ser His Gly Val 
            180                 185                 190         


Pro Glu His Pro Ala Leu Pro Thr Ala Ser Pro Gly Leu Gln Asp Ser 
        195                 200                 205             


Trp Glu Trp Gly Gly Cys Ser Pro Asp Met Gly Phe Gly Glu Arg Phe 
    210                 215                 220                 


Ser Lys Asp Phe Leu Asp Ser Arg Glu Pro His Arg Asp Ile His Ala 
225                 230                 235                 240 


Arg Met Arg Leu His Asn Asn Arg Val Gly Arg Gln Ala Val Met Glu 
                245                 250                 255     


Asn Met Arg Arg Lys Cys Lys Cys His Gly Thr Ser Gly Ser Cys Gln 
            260                 265                 270         


Leu Lys Thr Cys Trp Gln Val Thr Pro Glu Phe Arg Thr Val Gly Ala 
        275                 280                 285             


Leu Leu Arg Ser Arg Phe His Arg Ala Thr Leu Ile Arg Pro His Asn 
    290                 295                 300                 


Arg Asn Gly Gly Gln Leu Glu Pro Gly Pro Ala Gly Ala Pro Ser Pro 
305                 310                 315                 320 


Ala Pro Gly Ala Pro Gly Pro Arg Arg Arg Ala Ser Pro Ala Asp Leu 
                325                 330                 335     


Val Tyr Phe Glu Lys Ser Pro Asp Phe Cys Glu Arg Glu Pro Arg Leu 
            340                 345                 350         


Asp Ser Ala Gly Thr Val Gly Arg Leu Cys Asn Lys Ser Ser Ala Gly 
        355                 360                 365             


Ser Asp Gly Cys Gly Ser Met Cys Cys Gly Arg Gly His Asn Ile Leu 
    370                 375                 380                 


Arg Gln Thr Arg Ser Glu Arg Cys His Cys Arg Phe His Trp Cys Cys 
385                 390                 395                 400 


Phe Val Val Cys Glu Glu Cys Arg Ile Thr Glu Trp Val Ser Val Cys 
                405                 410                 415     


Lys 
    


<210>  8
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-Wnt10b

<400>  8

Met Leu Glu Glu Pro Arg Pro Arg Pro Pro Pro Ser Gly Leu Ala Gly 
1               5                   10                  15      


Leu Leu Phe Leu Ala Leu Cys Ser Arg Ala Leu Ser Asn Glu Ile Leu 
            20                  25                  30          


Gly Leu Lys Leu Pro Gly Glu Pro Pro Leu Thr Ala Asn Thr Val Cys 
        35                  40                  45              


Leu Thr Leu Ser Gly Leu Ser Lys Arg Gln Leu Gly Leu Cys Leu Arg 
    50                  55                  60                  


Asn Pro Asp Val Thr Ala Ser Ala Leu Gln Gly Leu His Ile Ala Val 
65                  70                  75                  80  


His Glu Cys Gln His Gln Leu Arg Asp Gln Arg Trp Asn Cys Ser Ala 
                85                  90                  95      


Leu Glu Gly Gly Gly Arg Leu Pro His His Ser Ala Ile Leu Lys Arg 
            100                 105                 110         


Gly Phe Arg Glu Ser Ala Phe Ser Phe Ser Met Leu Ala Ala Gly Val 
        115                 120                 125             


Met His Ala Val Ala Thr Ala Cys Ser Leu Gly Lys Leu Val Ser Cys 
    130                 135                 140                 


Gly Cys Gly Trp Lys Gly Ser Gly Glu Gln Asp Arg Leu Arg Ala Lys 
145                 150                 155                 160 


Leu Leu Gln Leu Gln Ala Leu Ser Arg Gly Lys Ser Phe Pro His Ser 
                165                 170                 175     


Leu Pro Ser Pro Gly Pro Gly Ser Ser Pro Ser Pro Gly Pro Gln Asp 
            180                 185                 190         


Thr Trp Glu Trp Gly Gly Cys Asn His Asp Met Asp Phe Gly Glu Lys 
        195                 200                 205             


Phe Ser Arg Asp Phe Leu Asp Ser Arg Glu Ala Pro Arg Asp Ile Gln 
    210                 215                 220                 


Ala Arg Met Arg Ile His Asn Asn Arg Val Gly Arg Gln Val Val Thr 
225                 230                 235                 240 


Glu Asn Leu Lys Arg Lys Cys Lys Cys His Gly Thr Ser Gly Ser Cys 
                245                 250                 255     


Gln Phe Lys Thr Cys Trp Arg Ala Ala Pro Glu Phe Arg Ala Val Gly 
            260                 265                 270         


Ala Ala Leu Arg Glu Arg Leu Gly Arg Ala Ile Phe Ile Asp Thr His 
        275                 280                 285             


Asn Arg Asn Ser Gly Ala Phe Gln Pro Arg Leu Arg Pro Arg Arg Leu 
    290                 295                 300                 


Ser Gly Glu Leu Val Tyr Phe Glu Lys Ser Pro Asp Phe Cys Glu Arg 
305                 310                 315                 320 


Asp Pro Thr Met Gly Ser Pro Gly Thr Arg Gly Arg Ala Cys Asn Lys 
                325                 330                 335     


Thr Ser Arg Leu Leu Asp Gly Cys Gly Ser Leu Cys Cys Gly Arg Gly 
            340                 345                 350         


His Asn Val Leu Arg Gln Thr Arg Val Glu Arg Cys His Cys Arg Phe 
        355                 360                 365             


His Trp Cys Cys Tyr Val Leu Cys Asp Glu Cys Lys Val Thr Glu Trp 
    370                 375                 380                 


Val Asn Val Cys Lys 
385                 


<210>  9
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-Wnt11

<400>  9

Met Arg Ala Arg Pro Gln Val Cys Glu Ala Leu Leu Phe Ala Leu Ala 
1               5                   10                  15      


Leu Gln Thr Gly Val Cys Tyr Gly Ile Lys Trp Leu Ala Leu Ser Lys 
            20                  25                  30          


Thr Pro Ser Ala Leu Ala Leu Asn Gln Thr Gln His Cys Lys Gln Leu 
        35                  40                  45              


Glu Gly Leu Val Ser Ala Gln Val Gln Leu Cys Arg Ser Asn Leu Glu 
    50                  55                  60                  


Leu Met His Thr Val Val His Ala Ala Arg Glu Val Met Lys Ala Cys 
65                  70                  75                  80  


Arg Arg Ala Phe Ala Asp Met Arg Trp Asn Cys Ser Ser Ile Glu Leu 
                85                  90                  95      


Ala Pro Asn Tyr Leu Leu Asp Leu Glu Arg Gly Thr Arg Glu Ser Ala 
            100                 105                 110         


Phe Val Tyr Ala Leu Ser Ala Ala Ala Ile Ser His Ala Ile Ala Arg 
        115                 120                 125             


Ala Cys Thr Ser Gly Asp Leu Pro Gly Cys Ser Cys Gly Pro Val Pro 
    130                 135                 140                 


Gly Glu Pro Pro Gly Pro Gly Asn Arg Trp Gly Gly Cys Ala Asp Asn 
145                 150                 155                 160 


Leu Ser Tyr Gly Leu Leu Met Gly Ala Lys Phe Ser Asp Ala Pro Met 
                165                 170                 175     


Lys Val Lys Lys Thr Gly Ser Gln Ala Asn Lys Leu Met Arg Leu His 
            180                 185                 190         


Asn Ser Glu Val Gly Arg Gln Ala Leu Arg Ala Ser Leu Glu Met Lys 
        195                 200                 205             


Cys Lys Cys His Gly Val Ser Gly Ser Cys Ser Ile Arg Thr Cys Trp 
    210                 215                 220                 


Lys Gly Leu Gln Glu Leu Gln Asp Val Ala Ala Asp Leu Lys Thr Arg 
225                 230                 235                 240 


Tyr Leu Ser Ala Thr Lys Val Val His Arg Pro Met Gly Thr Arg Lys 
                245                 250                 255     


His Leu Val Pro Lys Asp Leu Asp Ile Arg Pro Val Lys Asp Ser Glu 
            260                 265                 270         


Leu Val Tyr Leu Gln Ser Ser Pro Asp Phe Cys Met Lys Asn Glu Lys 
        275                 280                 285             


Val Gly Ser His Gly Thr Gln Asp Arg Gln Cys Asn Lys Thr Ser Asn 
    290                 295                 300                 


Gly Ser Asp Ser Cys Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Pro 
305                 310                 315                 320 


Tyr Thr Asp Arg Val Val Glu Arg Cys His Cys Lys Tyr His Trp Cys 
                325                 330                 335     


Cys Tyr Val Thr Cys Arg Arg Cys Glu Arg Thr Val Glu Arg Tyr Val 
            340                 345                 350         


Cys Lys 
        


<210>  10
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-Wnt16

<400>  10

Met Asp Arg Ala Ala Leu Leu Gly Leu Ala Arg Leu Cys Ala Leu Trp 
1               5                   10                  15      


Ala Ala Leu Leu Val Leu Phe Pro Tyr Gly Ala Gln Gly Asn Trp Met 
            20                  25                  30          


Trp Leu Gly Ile Ala Ser Phe Gly Val Pro Glu Lys Leu Gly Cys Ala 
        35                  40                  45              


Asn Leu Pro Leu Asn Ser Arg Gln Lys Glu Leu Cys Lys Arg Lys Pro 
    50                  55                  60                  


Tyr Leu Leu Pro Ser Ile Arg Glu Gly Ala Arg Leu Gly Ile Gln Glu 
65                  70                  75                  80  


Cys Gly Ser Gln Phe Arg His Glu Arg Trp Asn Cys Met Ile Thr Ala 
                85                  90                  95      


Ala Ala Thr Thr Ala Pro Met Gly Ala Ser Pro Leu Phe Gly Tyr Glu 
            100                 105                 110         


Leu Ser Ser Gly Thr Lys Glu Thr Ala Phe Ile Tyr Ala Val Met Ala 
        115                 120                 125             


Ala Gly Leu Val His Ser Val Thr Arg Ser Cys Ser Ala Gly Asn Met 
    130                 135                 140                 


Thr Glu Cys Ser Cys Asp Thr Thr Leu Gln Asn Gly Gly Ser Ala Ser 
145                 150                 155                 160 


Glu Gly Trp His Trp Gly Gly Cys Ser Asp Asp Val Gln Tyr Gly Met 
                165                 170                 175     


Trp Phe Ser Arg Lys Phe Leu Asp Phe Pro Ile Gly Asn Thr Thr Gly 
            180                 185                 190         


Lys Glu Asn Lys Val Leu Leu Ala Met Asn Leu His Asn Asn Glu Ala 
        195                 200                 205             


Gly Arg Gln Ala Val Ala Lys Leu Met Ser Val Asp Cys Arg Cys His 
    210                 215                 220                 


Gly Val Ser Gly Ser Cys Ala Val Lys Thr Cys Trp Lys Thr Met Ser 
225                 230                 235                 240 


Ser Phe Glu Lys Ile Gly His Leu Leu Lys Asp Lys Tyr Glu Asn Ser 
                245                 250                 255     


Ile Gln Ile Ser Asp Lys Thr Lys Arg Lys Met Arg Arg Arg Glu Lys 
            260                 265                 270         


Asp Gln Arg Lys Ile Pro Ile His Lys Asp Asp Leu Leu Tyr Val Asn 
        275                 280                 285             


Lys Ser Pro Asn Tyr Cys Val Glu Asp Lys Lys Leu Gly Ile Pro Gly 
    290                 295                 300                 


Thr Gln Gly Arg Glu Cys Asn Arg Thr Ser Glu Gly Ala Asp Gly Cys 
305                 310                 315                 320 


Asn Leu Leu Cys Cys Gly Arg Gly Tyr Asn Thr His Val Val Arg His 
                325                 330                 335     


Val Glu Arg Cys Glu Cys Lys Phe Ile Trp Cys Cys Tyr Val Arg Cys 
            340                 345                 350         


Arg Arg Cys Glu Ser Met Thr Asp Val His Thr Cys Lys 
        355                 360                 365 


<210>  11
<211>  349
<212>  PRT
<213>  Mus musculus

<400>  11

Met Thr Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Ile Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys 
            340                 345                 


<210>  12
<211>  349
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met Thr Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Ile Val Tyr Leu Arg Ile Gly Asp Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys 
            340                 345                 


<210>  13
<211>  349
<212>  PRT
<213>  Canis lupus familiaris

<400>  13

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Val Tyr Thr Cys Lys 
            340                 345                 


<210>  14
<211>  349
<212>  PRT
<213>  Bos taurus

<400>  14

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Ala Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Glu Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Ser Tyr Cys Glu Glu Asp Pro Ala Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Val Tyr Thr Cys Lys 
            340                 345                 


<210>  15
<211>  349
<212>  PRT
<213>  Macaca mulatta

<400>  15

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Thr Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys 
            340                 345                 


<210>  16
<211>  349
<212>  PRT
<213>  Gallus gallus

<400>  16

Met Asn Arg Lys Thr Arg Arg Trp Ile Phe His Ile Phe Leu Ser Leu 
1               5                   10                  15      


Gly Ile Val Tyr Ile Lys Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Ile Asn Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Lys Glu 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Lys Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Ile Leu Lys Asp Lys Tyr Asn Glu Ala Val Gln Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Met Cys Asn Lys Thr Ala Gln Gln Ser Asn Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ser Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Val Tyr Thr Cys Lys 
            340                 345                 


<210>  17
<211>  248
<212>  PRT
<213>  Xenopus tropicalis

<400>  17

Gly Ser Arg Glu Ala Ala Phe Met Tyr Ala Ile Ile Ala Ala Gly Val 
1               5                   10                  15      


Ala His Ala Ile Thr Thr Ala Cys Thr Gln Gly Asn Met Ser Asp Cys 
            20                  25                  30          


Gly Cys Asp Lys Glu Lys Gln Gly Gln Phe His Arg Glu Glu Gly Trp 
        35                  40                  45              


Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile Gly Phe Ser 
    50                  55                  60                  


Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala Arg Thr Leu 
65                  70                  75                  80  


Met Asn Leu His Asn Asn Glu Ala Gly Arg Arg Ile Leu Lys Glu Ser 
                85                  90                  95      


Met Lys Ser Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys Thr Thr 
            100                 105                 110         


Lys Thr Cys Trp Thr Thr Leu Pro Lys Phe Arg Glu Leu Gly Ala Ile 
        115                 120                 125             


Leu Arg Asp Lys Tyr Asn Glu Ala Ile Gln Val Glu Pro Val Arg Ala 
    130                 135                 140                 


Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Asn Ser Tyr Arg 
145                 150                 155                 160 


Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn Tyr 
                165                 170                 175     


Cys Glu Glu Asp Pro Met Thr Gly Ser Val Gly Thr Gln Gly Arg Leu 
            180                 185                 190         


Cys Asn Lys Thr Ala Gln His Thr Ser Ser Cys Asp Leu Met Cys Cys 
        195                 200                 205             


Gly Arg Gly Tyr Asn Thr His Gln Tyr Ser Arg Val Trp Gln Cys Asn 
    210                 215                 220                 


Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Asn Thr Cys Ser Glu 
225                 230                 235                 240 


Arg Thr Glu Val Phe Thr Cys Lys 
                245             


<210>  18
<211>  349
<212>  PRT
<213>  Danio rerio

<400>  18

Met Ser Arg Lys Thr Arg Arg Trp Ile Phe His Ile Phe Leu Cys Leu 
1               5                   10                  15      


Gly Ile Ile Tyr Leu Lys Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Thr Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ala Gln Met Gly Ile Asn Glu Cys Gln Phe Gln Phe Lys Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Lys Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Thr Leu 
        115                 120                 125             


Ser Gly Cys Gly Cys Asp Lys Glu Lys Gln Gly Phe Tyr Asn Gln Glu 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Leu 
145                 150                 155                 160 


Ser Phe Ser Lys Val Phe Leu Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Val Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Lys Asn Met Arg Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Lys Phe Arg Gln Leu 
    210                 215                 220                 


Gly Tyr Ile Leu Lys Glu Arg Tyr Asn His Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Ala Phe Leu Lys Val Lys Lys 
                245                 250                 255     


Pro Tyr Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Ala Asp Pro Val Thr Gly Ser Met Gly 
        275                 280                 285             


Thr Gln Gly Arg Ile Cys Asn Lys Thr Ala Gln His Thr Asn Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ser Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe Leu Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Val Tyr Thr Cys Lys 
            340                 345                 


<210>  19
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19-Wnt7a_Delta32-212

<400>  19

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Thr 
            20                  25                  30          


Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu Gly Tyr Val Leu Lys 
        35                  40                  45              


Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro Val Arg Ala Ser Arg 
    50                  55                  60                  


Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Leu Ser Tyr Arg 
65                  70                  75                  80  


Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn Tyr 
                85                  90                  95      


Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr Gln Gly Arg Ala 
            100                 105                 110         


Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys Asp Leu Met Cys Cys 
        115                 120                 125             


Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg Val Trp Gln Cys Asn 
    130                 135                 140                 


Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Asn Thr Cys Ser Glu 
145                 150                 155                 160 


Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                165                 170                 175     


Ala 
    


<210>  20
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wnt7a_Delta-32-212 F-Primer

<400>  20
gcttctcctc agtggtagct acgtgctgga ccacactgcc ac                          42


<210>  21
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  21-Wnt7a_Delta-32-212 R-Primer

<400>  21
aagaattctc aagcgtaatc tggaacatcg tatgggtact tgcacgtgta catctccg         58


<210>  22
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  22-Wnt7a_Delta32-149

<400>  22

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Gly 
            20                  25                  30          


Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile Gly Phe Ala Lys Val Phe 
        35                  40                  45              


Val Asp Ala Arg Glu Ile Lys Gln Asn Ala Arg Thr Leu Met Asn Leu 
    50                  55                  60                  


His Asn Asn Glu Ala Gly Arg Lys Ile Leu Glu Glu Asn Met Lys Leu 
65                  70                  75                  80  


Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys Thr Thr Lys Thr Cys 
                85                  90                  95      


Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu Gly Tyr Val Leu Lys Asp 
            100                 105                 110         


Lys Tyr Asn Glu Ala Val His Val Glu Pro Val Arg Ala Ser Arg Asn 
        115                 120                 125             


Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Leu Ser Tyr Arg Lys 
    130                 135                 140                 


Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn Tyr Cys 
145                 150                 155                 160 


Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr Gln Gly Arg Ala Cys 
                165                 170                 175     


Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys Asp Leu Met Cys Cys Gly 
            180                 185                 190         


Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg Val Trp Gln Cys Asn Cys 
        195                 200                 205             


Lys Phe His Trp Cys Cys Tyr Val Lys Cys Asn Thr Cys Ser Glu Arg 
    210                 215                 220                 


Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
225                 230                 235                 240 


<210>  23
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  23-Wnt7a_Delta32-149 F-Primer

<400>  23
aaggatccac catgaaccgg aaagcgcggc gctgcctggg ccacctcttt ctcagcctgg       60

gcatggtcta cctccggatc ggtggcttct cctcagtggt agctggtggc tgctctgccg      120

acatc                                                                  125


<210>  24
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  24-Wnt7a_Delta32-149 R-Primer

<400>  24
aagaattctc aagcgtaatc tggaacatcg tatgggtact tgcacgtgta catctccg         58


<210>  25
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25-Wnt7a_Delta32-99

<400>  25

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Gly 
            20                  25                  30          


Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala Ala Gly Val Ala 
        35                  40                  45              


His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu Ser Asp Cys Gly 
    50                  55                  60                  


Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp Glu Gly Trp Lys 
65                  70                  75                  80  


Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile Gly Phe Ala Lys 
                85                  90                  95      


Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala Arg Thr Leu Met 
            100                 105                 110         


Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu Glu Glu Asn Met 
        115                 120                 125             


Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys Thr Thr Lys 
    130                 135                 140                 


Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu Gly Tyr Val Leu 
145                 150                 155                 160 


Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro Val Arg Ala Ser 
                165                 170                 175     


Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Leu Ser Tyr 
            180                 185                 190         


Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn 
        195                 200                 205             


Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr Gln Gly Arg 
    210                 215                 220                 


Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys Asp Leu Met Cys 
225                 230                 235                 240 


Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg Val Trp Gln Cys 
                245                 250                 255     


Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Asn Thr Cys Ser 
            260                 265                 270         


Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr Asp Val Pro Asp 
        275                 280                 285             


Tyr Ala 
    290 


<210>  26
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26-Wnt7a_Delta32-99 F-Primer

<400>  26
aaggatccac catgaaccgg aaagcgcggc gctgcctggg ccacctcttt ctcagcctgg       60

gcatggtcta cctccggatc ggtggcttct cctcagtggt agctgggagc cgggaggctg      120

cgttc                                                                  125


<210>  27
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  27-Wnt7a_Delta32-99 R-Primer

<400>  27
aagaattctc aagcgtaatc tggaacatcg tatgggtact tgcacgtgta catctccg         58


<210>  28
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28-Wnt7a_Delta32-49

<400>  28

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Ala 
            20                  25                  30          


Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu Gly Ser 
        35                  40                  45              


Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly Arg Trp 
    50                  55                  60                  


Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu Leu Lys 
65                  70                  75                  80  


Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala Ala Gly 
                85                  90                  95      


Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu Ser Asp 
            100                 105                 110         


Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp Glu Gly 
        115                 120                 125             


Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile Gly Phe 
    130                 135                 140                 


Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala Arg Thr 
145                 150                 155                 160 


Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu Glu Glu 
                165                 170                 175     


Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys Thr 
            180                 185                 190         


Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu Gly Tyr 
        195                 200                 205             


Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro Val Arg 
    210                 215                 220                 


Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Leu 
225                 230                 235                 240 


Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys Ser 
                245                 250                 255     


Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr Gln 
            260                 265                 270         


Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys Asp Leu 
        275                 280                 285             


Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg Val Trp 
    290                 295                 300                 


Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Asn Thr 
305                 310                 315                 320 


Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr Asp Val 
                325                 330                 335     


Pro Asp Tyr Ala 
            340 


<210>  29
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29-Wnt7a_Delta32-49 F-Primer

<400>  29
aaggatccac catgaaccgg aaagcgcggc gctgcctggg ccacctcttt ctcagcctgg       60

gcatggtcta cctccggatc ggtggcttct cctcagtggt agctgcgatc tgccagagcc      120

ggcccgac                                                               128


<210>  30
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30-Wnt7a_Delta32-49 R-Primer

<400>  30
aagaattctc aagcgtaatc tggaacatcg tatgggtact tgcacgtgta catctccg         58


<210>  31
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31-Wnt7a_Delta213-349

<400>  31

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
    210                 215                 220     


<210>  32
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  32-Wnt7a_Delta213-349 F-Primer

<400>  32
aaggatccac catgaaccgg aaagcgcggc gctg                                   34


<210>  33
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  33-Wnt7a_Delta213-349 R-Primer

<400>  33
aagaattctc aagcgtaatc tggaacatcg tatgggtact tggtggtgca cgagcctgac       60


<210>  34
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34-Wnt7a_Delta251-349

<400>  34

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Tyr Pro Tyr Asp Val Pro Asp 
                245                 250                 255     


Tyr Ala 
        


<210>  35
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  35-Wnt7a_Delta251-349 F-Primer

<400>  35
aaggatccac catgaaccgg aaagcgcggc gctg                                   34


<210>  36
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  36-Wnt7a_Delta251-349 R-Primer

<400>  36
aagaattctc aagcgtaatc tggaacatcg tatgggtagg tgggccgctt gttgcggctg       60


<210>  37
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37-Wnt7a_Delta301-349

<400>  37

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Tyr Pro Tyr Asp 
    290                 295                 300                 


Val Pro Asp Tyr Ala 
305                 


<210>  38
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  38-Wnt7a_Delta301-349 F-Primer

<400>  38
aaggatccac catgaaccgg aaagcgcggc gctg                                   34


<210>  39
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  39-Wnt7a_Delta301-349 R-Primer

<400>  39
aagaattctc aagcgtaatc tggaacatcg tatgggtact ggggagccgt cttgttgcag       60


<210>  40
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40-Wnt7a_Delta32-99_Delta301-349

<400>  40

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Gly 
            20                  25                  30          


Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala Ala Gly Val Ala 
        35                  40                  45              


His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu Ser Asp Cys Gly 
    50                  55                  60                  


Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp Glu Gly Trp Lys 
65                  70                  75                  80  


Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile Gly Phe Ala Lys 
                85                  90                  95      


Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala Arg Thr Leu Met 
            100                 105                 110         


Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu Glu Glu Asn Met 
        115                 120                 125             


Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys Thr Thr Lys 
    130                 135                 140                 


Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu Gly Tyr Val Leu 
145                 150                 155                 160 


Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro Val Arg Ala Ser 
                165                 170                 175     


Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Leu Ser Tyr 
            180                 185                 190         


Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn 
        195                 200                 205             


Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr Gln Gly Arg 
    210                 215                 220                 


Ala Cys Asn Lys Thr Ala Pro Gln Tyr Pro Tyr Asp Val Pro Asp Tyr 
225                 230                 235                 240 


Ala 
    


<210>  41
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41-Wnt7a_Delta32-99_Delta301-349 F-Prime

<400>  41
aaggatccac catgaaccgg aaagcgcggc gctgcctggg ccacctcttt ctcagcctgg       60

gcatggtcta cctccggatc ggtggcttct cctcagtggt agctgggagc cgggaggctg      120

cgttc                                                                  125


<210>  42
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  42-Wnt7a_Delta32-99_Delta301-349 R-Primer

<400>  42
aagaattctc aagcgtaatc tggaacatcg tatgggtact ggggagccgt cttgttgcag       60


<210>  43
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43-Wnt7a_Delta1-99_Delta301-349

<400>  43

Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala Ala Gly Val 
1               5                   10                  15      


Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu Ser Asp Cys 
            20                  25                  30          


Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp Glu Gly Trp 
        35                  40                  45              


Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile Gly Phe Ala 
    50                  55                  60                  


Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala Arg Thr Leu 
65                  70                  75                  80  


Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu Glu Glu Asn 
                85                  90                  95      


Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys Thr Thr 
            100                 105                 110         


Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu Gly Tyr Val 
        115                 120                 125             


Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro Val Arg Ala 
    130                 135                 140                 


Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Leu Ser 
145                 150                 155                 160 


Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys Ser Pro 
                165                 170                 175     


Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr Gln Gly 
            180                 185                 190         


Arg Ala Cys Asn Lys Thr Ala Pro Gln Tyr Pro Tyr Asp Val Pro Asp 
        195                 200                 205             


Tyr Ala 
    210 


<210>  44
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  44-Wnt7a_Delta1-99_Delta301-349 F-Primer

<400>  44
aaggatccac catggggagc cgggaggctg cgttc                                  35


<210>  45
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  45-Wnt7a_Delta1-99_Delta301-349 R-Primer

<400>  45
aagaattctc aagcgtaatc tggaacatcg tatgggtact ggggagccgt cttgttgcag       60


<210>  46
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46-Wnt7a_DeltaEBP*GSGS

<400>  46

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Gly 
225                 230                 235                 240 


Ser Gly Ser Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr 
                245                 250                 255     


Ile Glu Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser 
            260                 265                 270         


Val Gly Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser 
        275                 280                 285             


Gly Cys Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr 
    290                 295                 300                 


Ala Arg Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val 
305                 310                 315                 320 


Lys Cys Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr 
                325                 330                 335     


Pro Tyr Asp Val Pro Asp Tyr Ala 
            340                 


<210>  47
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  47-Wnt7a_DeltaEBP*GSGS F-Primer

<400>  47
vvcaacgagg ccgttcacgt ggagcctggt tcaggttcac tgtcgtaccg caagcccatg       60

gacacggac                                                               69


<210>  48
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  48-Wnt7a_DeltaEBP*GSGS R-Primer

<400>  48
gtccgtgtcc atgggcttgc ggtacgacag tgaacctgaa ccaggctcca cgtgaacggc       60

ctcgttg                                                                 67


<210>  49
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49-Wnt7a_Delta1-49

<400>  49

Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu Gly 
1               5                   10                  15      


Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly Arg 
            20                  25                  30          


Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu Leu 
        35                  40                  45              


Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala Ala 
    50                  55                  60                  


Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu Ser 
65                  70                  75                  80  


Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp Glu 
                85                  90                  95      


Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile Gly 
            100                 105                 110         


Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala Arg 
        115                 120                 125             


Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu Glu 
    130                 135                 140                 


Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys 
145                 150                 155                 160 


Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu Gly 
                165                 170                 175     


Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro Val 
            180                 185                 190         


Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro 
        195                 200                 205             


Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys 
    210                 215                 220                 


Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr 
225                 230                 235                 240 


Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys Asp 
                245                 250                 255     


Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg Val 
            260                 265                 270         


Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Asn 
        275                 280                 285             


Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr Asp 
    290                 295                 300                 


Val Pro Asp Tyr Ala 
305                 


<210>  50
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  50-Wnt7a_Delta1-49 F-Primer

<400>  50
aaggatccac catggcgatc tgccagagcc ggcccgac                               38


<210>  51
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  51-Wnt7a_Delta1-49 R-Primer

<400>  51
aagaattctc aagcgtaatc tggaacatcg tatgggtact tgcacgtgta catctccg         58


<210>  52
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-Wnt7a_Delta1-99

<400>  52

Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala Ala Gly Val 
1               5                   10                  15      


Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu Ser Asp Cys 
            20                  25                  30          


Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp Glu Gly Trp 
        35                  40                  45              


Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile Gly Phe Ala 
    50                  55                  60                  


Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala Arg Thr Leu 
65                  70                  75                  80  


Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu Glu Glu Asn 
                85                  90                  95      


Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys Thr Thr 
            100                 105                 110         


Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu Gly Tyr Val 
        115                 120                 125             


Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro Val Arg Ala 
    130                 135                 140                 


Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Leu Ser 
145                 150                 155                 160 


Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys Ser Pro 
                165                 170                 175     


Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr Gln Gly 
            180                 185                 190         


Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys Asp Leu Met 
        195                 200                 205             


Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg Val Trp Gln 
    210                 215                 220                 


Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Asn Thr Cys 
225                 230                 235                 240 


Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr Asp Val Pro 
                245                 250                 255     


Asp Tyr Ala 
            


<210>  53
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  53-Wnt7a_Delta1-99 F-Primer

<400>  53
aaggatccac catggggagc cgggaggctg cgttc                                  35


<210>  54
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  54-Wnt7a_Delta1-99 R-Primer

<400>  54
aagaattctc aagcgtaatc tggaacatcg tatgggtact tgcacgtgta catctccg         58


<210>  55
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  55-Wnt7a_Delta1-149

<400>  55

Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile Gly Phe Ala Lys Val 
1               5                   10                  15      


Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala Arg Thr Leu Met Asn 
            20                  25                  30          


Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu Glu Glu Asn Met Lys 
        35                  40                  45              


Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys Thr Thr Lys Thr 
    50                  55                  60                  


Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu Gly Tyr Val Leu Lys 
65                  70                  75                  80  


Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro Val Arg Ala Ser Arg 
                85                  90                  95      


Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Leu Ser Tyr Arg 
            100                 105                 110         


Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn Tyr 
        115                 120                 125             


Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr Gln Gly Arg Ala 
    130                 135                 140                 


Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys Asp Leu Met Cys Cys 
145                 150                 155                 160 


Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg Val Trp Gln Cys Asn 
                165                 170                 175     


Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Asn Thr Cys Ser Glu 
            180                 185                 190         


Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr Asp Val Pro Asp Tyr 
        195                 200                 205             


Ala 
    


<210>  56
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  56-Wnt7a_Delta1-149 F-Primer

<400>  56
aaggatccac catgggtggc tgctctgccg acatc                                  35


<210>  57
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  57-Wnt7a_Delta1-149 R-Primer

<400>  57
aagaattctc aagcgtaatc tggaacatcg tatgggtact tgcacgtgta catctccg         58


<210>  58
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  58-Wnt7a_Delta3aa*GSG

<400>  58

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Gly Ser Gly Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr 
            340                 345                 350         


Asp Val Pro Asp Tyr Ala 
        355             


<210>  59
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  59-Wnt7a_Delta3aa*GSG F-Primer

<400>  59
caaggtcttt gtggatgccc gggagggctc ggggaatgcc cggactctca tgaacttgca       60

c                                                                       61


<210>  60
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  60-Wnt7a_Delta3aa*GSG R-Primer

<400>  60
gtgcaagttc atgagagtcc gggcattccc cgagccctcc cgggcatcca caaagacctt       60

g                                                                       61


<210>  61
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  61-Wnt7a_Delta3aa*ESP

<400>  61

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Pro Val Arg Ala Ser 
                165                 170                 175     


Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Asn Ala Arg 
            180                 185                 190         


Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu Glu 
        195                 200                 205             


Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys 
    210                 215                 220                 


Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu Gly 
225                 230                 235                 240 


Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro Val 
                245                 250                 255     


Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro 
            260                 265                 270         


Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu Lys 
        275                 280                 285             


Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr 
    290                 295                 300                 


Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys Asp 
305                 310                 315                 320 


Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg Val 
                325                 330                 335     


Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Asn 
            340                 345                 350         


Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr Asp 
        355                 360                 365             


Val Pro Asp Tyr Ala 
    370             


<210>  62
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  62-Wnt7a_Delta3aa*ESP F-Primer

<400>  62
tggcttcttg atcttcagga aggtgggccg cttgttgcgg ctggcacgca caggctcccg       60

ggcatccaca aagaccttg                                                    79


<210>  63
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  63-Wnt7a_Delta3aa*ESP R-Primer

<400>  63
cctgtgcgtg ccagccgcaa caagcggccc accttcctga agatcaagaa gccaaatgcc       60

cggactctca tgaacttgc                                                    79


<210>  64
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  64-Wnt7a_Delta213-349*ESP@172

<400>  64

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Pro Val Arg Ala Ser 
                165                 170                 175     


Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Asn Ala Arg 
            180                 185                 190         


Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu Glu 
        195                 200                 205             


Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys 
    210                 215                 220                 


Thr Thr Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
225                 230                 235     


<210>  65
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  65-Wnt7a_Delta213-349*ESP@172 F-Primer

<400>  65
aaggatccac catgaaccgg aaagcgcggc gctg                                   34


<210>  66
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  66-Wnt7a_Delta213-349*ESP@172 R-Primer

<400>  66
aagaattctc aagcgtaatc tggaacatcg tatgggtact tggtggtgca cgagcctgac       60


<210>  67
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  67-Wnt7a_Delta213-349*ESP

<400>  67

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Pro Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe 
    210                 215                 220                 


Leu Lys Ile Lys Lys Pro Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
225                 230                 235                 


<210>  68
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  68-Wnt7a_Delta213-349*ESP F-Primer

<400>  68
aaggatccac catgaaccgg aaagcgcggc gctg                                   34


<210>  69
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  69-Wnt7a_Delta213-349*ESP R1-Primer

<400>  69
gcttgttgcg gctggcacgc acaggtcccg atcccttggt ggtgcacgag cctgacac         58


<210>  70
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  70-Wnt7a_Delta213-349*ESP R2-Primer

<400>  70
agaattctca agcgtaatct ggaacatcgt atgggtatgg cttcttgatc ttcaggaagg       60

tgggccgctt gttgcggctg gcacgcac                                          88


<210>  71
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71-Wnt7a_*ESPDelta213-349

<400>  71

Pro Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys 
1               5                   10                  15      


Lys Pro Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu 
            20                  25                  30          


Ser Leu Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val 
        35                  40                  45              


Ala Leu Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro 
    50                  55                  60                  


Arg Gln Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile 
65                  70                  75                  80  


Gly Glu Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg 
                85                  90                  95      


Asn Gly Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly 
            100                 105                 110         


Lys Glu Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile 
        115                 120                 125             


Ile Ala Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly 
    130                 135                 140                 


Asn Leu Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His 
145                 150                 155                 160 


Arg Asp Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr 
                165                 170                 175     


Gly Ile Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln 
            180                 185                 190         


Asn Ala Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys 
        195                 200                 205             


Ile Leu Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser 
    210                 215                 220                 


Gly Ser Cys Thr Thr Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
225                 230                 235                 


<210>  72
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  72-Wnt7a_*ESPDelta213-349 F1-Primer

<400>  72
cccaccttcc tgaagatcaa gaagccagga tcgggaatga accggaaagc gcggcgctg        59


<210>  73
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  73-Wnt7a_*ESPDelta213-349 F2-Primer

<400>  73
aggatcccca atgcctgtgc gtgccagccg caacaagcgg cccaccttcc tgaagatcaa       60

g                                                                       61


<210>  74
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  74-Wnt7a_*ESPDelta213-349 R1-Primer

<400>  74
aagaattctc aagcgtaatc tggaacatcg tatgggtact tggtggtgca cgagcctgac       60


<210>  75
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  75-HALO*ESP-HA

<400>  75

Met Ala Glu Ile Gly Thr Gly Phe Pro Phe Asp Pro His Tyr Val Glu 
1               5                   10                  15      


Val Leu Gly Glu Arg Met His Tyr Val Asp Val Gly Pro Arg Asp Gly 
            20                  25                  30          


Thr Pro Val Leu Phe Leu His Gly Asn Pro Thr Ser Ser Tyr Val Trp 
        35                  40                  45              


Arg Asn Ile Ile Pro His Val Ala Pro Thr His Arg Cys Ile Ala Pro 
    50                  55                  60                  


Asp Leu Ile Gly Met Gly Lys Ser Asp Lys Pro Asp Leu Gly Tyr Phe 
65                  70                  75                  80  


Phe Asp Asp His Val Arg Phe Met Asp Ala Phe Ile Glu Ala Leu Gly 
                85                  90                  95      


Leu Glu Glu Val Val Leu Val Ile His Asp Trp Gly Ser Ala Leu Gly 
            100                 105                 110         


Phe His Trp Ala Lys Arg Asn Pro Glu Arg Val Lys Gly Ile Ala Phe 
        115                 120                 125             


Met Glu Phe Ile Arg Pro Ile Pro Thr Trp Asp Glu Trp Pro Glu Phe 
    130                 135                 140                 


Ala Arg Glu Thr Phe Gln Ala Phe Arg Thr Thr Asp Val Gly Arg Lys 
145                 150                 155                 160 


Leu Ile Ile Asp Gln Asn Val Phe Ile Glu Gly Thr Leu Pro Met Gly 
                165                 170                 175     


Val Val Arg Pro Leu Thr Glu Val Glu Met Asp His Tyr Arg Glu Pro 
            180                 185                 190         


Phe Leu Asn Pro Val Asp Arg Glu Pro Leu Trp Arg Phe Pro Asn Glu 
        195                 200                 205             


Leu Pro Ile Ala Gly Glu Pro Ala Asn Ile Val Ala Leu Val Glu Glu 
    210                 215                 220                 


Tyr Met Asp Trp Leu His Gln Ser Pro Val Pro Lys Leu Leu Phe Trp 
225                 230                 235                 240 


Gly Thr Pro Gly Val Leu Ile Pro Pro Ala Glu Ala Ala Arg Leu Ala 
                245                 250                 255     


Lys Ser Leu Pro Asn Cys Lys Ala Val Asp Ile Gly Pro Gly Leu Asn 
            260                 265                 270         


Leu Leu Gln Glu Asp Asn Pro Asp Leu Ile Gly Ser Glu Ile Ala Arg 
        275                 280                 285             


Trp Leu Ser Thr Leu Glu Ile Ser Gly Gly Ser Gly Pro Val Arg Ala 
    290                 295                 300                 


Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro Tyr Pro 
305                 310                 315                 320 


Tyr Asp Val Pro Asp Tyr Ala 
                325         


<210>  76
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  76-HALO*ESP-HA F-Primer

<400>  76
atataagctt accatgatat aagcttatgg aggatctgta ctttcag                     47


<210>  77
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  77-HALO*ESP-HA R-Primer

<400>  77
caagcggccc accttcctga agatcaagaa gccataccca tacgatgttc cagattacgc       60

ttgagaattc tt                                                           72


<210>  78
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  78-HALO*ESP

<400>  78

Met Ala Glu Ile Gly Thr Gly Phe Pro Phe Asp Pro His Tyr Val Glu 
1               5                   10                  15      


Val Leu Gly Glu Arg Met His Tyr Val Asp Val Gly Pro Arg Asp Gly 
            20                  25                  30          


Thr Pro Val Leu Phe Leu His Gly Asn Pro Thr Ser Ser Tyr Val Trp 
        35                  40                  45              


Arg Asn Ile Ile Pro His Val Ala Pro Thr His Arg Cys Ile Ala Pro 
    50                  55                  60                  


Asp Leu Ile Gly Met Gly Lys Ser Asp Lys Pro Asp Leu Gly Tyr Phe 
65                  70                  75                  80  


Phe Asp Asp His Val Arg Phe Met Asp Ala Phe Ile Glu Ala Leu Gly 
                85                  90                  95      


Leu Glu Glu Val Val Leu Val Ile His Asp Trp Gly Ser Ala Leu Gly 
            100                 105                 110         


Phe His Trp Ala Lys Arg Asn Pro Glu Arg Val Lys Gly Ile Ala Phe 
        115                 120                 125             


Met Glu Phe Ile Arg Pro Ile Pro Thr Trp Asp Glu Trp Pro Glu Phe 
    130                 135                 140                 


Ala Arg Glu Thr Phe Gln Ala Phe Arg Thr Thr Asp Val Gly Arg Lys 
145                 150                 155                 160 


Leu Ile Ile Asp Gln Asn Val Phe Ile Glu Gly Thr Leu Pro Met Gly 
                165                 170                 175     


Val Val Arg Pro Leu Thr Glu Val Glu Met Asp His Tyr Arg Glu Pro 
            180                 185                 190         


Phe Leu Asn Pro Val Asp Arg Glu Pro Leu Trp Arg Phe Pro Asn Glu 
        195                 200                 205             


Leu Pro Ile Ala Gly Glu Pro Ala Asn Ile Val Ala Leu Val Glu Glu 
    210                 215                 220                 


Tyr Met Asp Trp Leu His Gln Ser Pro Val Pro Lys Leu Leu Phe Trp 
225                 230                 235                 240 


Gly Thr Pro Gly Val Leu Ile Pro Pro Ala Glu Ala Ala Arg Leu Ala 
                245                 250                 255     


Lys Ser Leu Pro Asn Cys Lys Ala Val Asp Ile Gly Pro Gly Leu Asn 
            260                 265                 270         


Leu Leu Gln Glu Asp Asn Pro Asp Leu Ile Gly Ser Glu Ile Ala Arg 
        275                 280                 285             


Trp Leu Ser Thr Leu Glu Ile Ser Gly Gly Ser Gly Pro Val Arg Ala 
    290                 295                 300                 


Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro 
305                 310                 315             


<210>  79
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  79-HALO*ESP F-Primer

<400>  79
atataagctt accatgatat aagcttatgg aggatctgta ctttcag                     47


<210>  80
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  80-HALO*ESP R-Primer

<400>  80
cttcaggaag gtgggccgct tgttgcggct ggcacgcaca ggtcccgatc caccggaaat       60

ctccagagta g                                                            71


<210>  81
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  81-Wnt7a-BirA-myc

<400>  81

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Phe Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe Gln Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Lys Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Thr Gly Gly 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Ser Asp Phe Lys Asn Leu Ile Trp Leu Lys 
        355                 360                 365             


Glu Val Asp Ser Thr Gln Glu Arg Leu Lys Glu Trp Asn Val Ser Tyr 
    370                 375                 380                 


Gly Thr Ala Leu Val Ala Asp Arg Gln Thr Lys Gly Arg Gly Gly Leu 
385                 390                 395                 400 


Gly Arg Lys Trp Leu Ser Gln Glu Gly Gly Leu Tyr Phe Ser Phe Leu 
                405                 410                 415     


Leu Asn Pro Lys Glu Phe Glu Asn Leu Leu Gln Leu Pro Leu Val Leu 
            420                 425                 430         


Gly Leu Ser Val Ser Glu Ala Leu Glu Glu Ile Thr Glu Ile Pro Phe 
        435                 440                 445             


Ser Leu Lys Trp Pro Asn Asp Val Tyr Phe Gln Glu Lys Lys Val Ser 
    450                 455                 460                 


Gly Val Leu Cys Glu Leu Ser Lys Asp Lys Leu Ile Val Gly Ile Gly 
465                 470                 475                 480 


Ile Asn Val Asn Gln Arg Glu Ile Pro Glu Glu Ile Lys Asp Arg Ala 
                485                 490                 495     


Thr Thr Leu Tyr Glu Ile Thr Gly Lys Asp Trp Asp Arg Lys Glu Val 
            500                 505                 510         


Leu Leu Lys Val Leu Lys Arg Ile Ser Glu Asn Leu Lys Lys Phe Lys 
        515                 520                 525             


Glu Lys Ser Phe Lys Glu Phe Lys Gly Lys Ile Glu Ser Lys Met Leu 
    530                 535                 540                 


Tyr Leu Gly Glu Glu Val Lys Leu Leu Gly Glu Gly Lys Ile Thr Gly 
545                 550                 555                 560 


Lys Leu Val Gly Leu Ser Glu Lys Gly Gly Ala Leu Ile Leu Thr Glu 
                565                 570                 575     


Glu Gly Ile Lys Glu Ile Leu Ser Gly Glu Phe Ser Leu Arg Arg Ser 
            580                 585                 590         


Leu Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
        595                 600                 


<210>  82
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  82-Wnt7a-BirA-myc F1-Primer

<400>  82
tatagaattc gccaccatga accggaaagc gcggcgctgc c                           41


<210>  83
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  83-Wnt7a-BirA-myc F2-Primer

<400>  83
tataaccggt ggaagtggaa gtggaagtgg aagtgacttc aagaacctga tctggctg         58


<210>  84
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  84-Wnt7a-BirA-myc R1-Primer

<400>  84
tatagtcgac catatgtata taaccggtct tgcacgtgta catctccgtg cgc              53


<210>  85
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  85-Wnt7a-BirA-myc R2-Primer

<400>  85
tatacatatg tcaaagatct tcctcggata tgagtttctg ctcctcgagg cttcttctca       60

ggctg                                                                   65


<210>  86
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  86-Myc-BirA-ESP

<400>  86

Met Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp Phe Lys Asn Leu 
1               5                   10                  15      


Ile Trp Leu Lys Glu Val Asp Ser Thr Gln Glu Arg Leu Lys Glu Trp 
            20                  25                  30          


Asn Val Ser Tyr Gly Thr Ala Leu Val Ala Asp Arg Gln Thr Lys Gly 
        35                  40                  45              


Arg Gly Gly Leu Gly Arg Lys Trp Leu Ser Gln Glu Gly Gly Leu Tyr 
    50                  55                  60                  


Phe Ser Phe Leu Leu Asn Pro Lys Glu Phe Glu Asn Leu Leu Gln Leu 
65                  70                  75                  80  


Pro Leu Val Leu Gly Leu Ser Val Ser Glu Ala Leu Glu Glu Ile Thr 
                85                  90                  95      


Glu Ile Pro Phe Ser Leu Lys Trp Pro Asn Asp Val Tyr Phe Gln Glu 
            100                 105                 110         


Lys Lys Val Ser Gly Val Leu Cys Glu Leu Ser Lys Asp Lys Leu Ile 
        115                 120                 125             


Val Gly Ile Gly Ile Asn Val Asn Gln Arg Glu Ile Pro Glu Glu Ile 
    130                 135                 140                 


Lys Asp Arg Ala Thr Thr Leu Tyr Glu Ile Thr Gly Lys Asp Trp Asp 
145                 150                 155                 160 


Arg Lys Glu Val Leu Leu Lys Val Leu Lys Arg Ile Ser Glu Asn Leu 
                165                 170                 175     


Lys Lys Phe Lys Glu Lys Ser Phe Lys Glu Phe Lys Gly Lys Ile Glu 
            180                 185                 190         


Ser Lys Met Leu Tyr Leu Gly Glu Glu Val Lys Leu Leu Gly Glu Gly 
        195                 200                 205             


Lys Ile Thr Gly Lys Leu Val Gly Leu Ser Glu Lys Gly Gly Ala Leu 
    210                 215                 220                 


Ile Leu Thr Glu Glu Gly Ile Lys Glu Ile Leu Ser Gly Glu Phe Ser 
225                 230                 235                 240 


Leu Arg Arg Ser Leu Glu Gly Ser Gly Pro Val Arg Ala Ser Arg Asn 
                245                 250                 255     


Lys Arg Pro Thr Phe Leu Lys Ile Lys Lys Pro 
            260                 265         


<210>  87
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  87-Myc-BirA-ESP F-Primer

<400>  87
tatactcgag ggatcgggac ctgtgcgtgc cagccgcaac                             40


<210>  88
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  88-Myc-BirA-ESP R-Primer

<400>  88
gtcgactcat ggcttcttga tcttcaggaa g                                      31


<210>  89
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  89-Wnt7a_ESP*Scramb

<400>  89

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Asn Lys Lys Leu Ala Ser Pro Arg Ile Thr Phe Lys Pro Lys Arg Arg 
                245                 250                 255     


Val Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr 
            340                 345                 350         


Asp Val Pro Asp Tyr Ala 
        355             


<210>  90
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  90-Wnt7a_ESP*Scramb F-Primer

<400>  90
tggcgagccc gcgcattacc tttaaaccga aacgccgcgt gctgtcgtac cgcaagccca       60

tg                                                                      62


<210>  91
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  91-Wnt7a_ESP*Scramb R-Primer

<400>  91
ggtttaaagg taatgcgcgg gctcgccagt tttttgttcg gctccacgtg aacggcctcg       60

ttg                                                                     63


<210>  92
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  92-Wnt7a_K247A

<400>  92

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Ala Arg Pro Thr Phe Leu Lys Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr 
            340                 345                 350         


Asp Val Pro Asp Tyr Ala 
        355             


<210>  93
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  93-Wnt7a_K247A F-Primer

<400>  93
gtgcgtgcca gccgcaacgc gcggcccacc ttcctgaaga tc                          42


<210>  94
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  94-Wnt7a_K247A R-Primer

<400>  94
gatcttcagg aaggtgggcc gcgcgttgcg gctggcacgc ac                          42


<210>  95
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  95-Wnt7a_K253A

<400>  95

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Ala Ile Lys Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr 
            340                 345                 350         


Asp Val Pro Asp Tyr Ala 
        355             


<210>  96
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  96-Wnt7a_K253A F-Primer

<400>  96
caagcggccc accttcctgg cgatcaagaa gccactgtcg tac                         43


<210>  97
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  97-Wnt7a_K253A R-Primer

<400>  97
gtacgacagt ggcttcttga tcgccaggaa ggtgggccgc ttg                         43


<210>  98
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  98-Wnt7a_K255A

<400>  98

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Ala Lys 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr 
            340                 345                 350         


Asp Val Pro Asp Tyr Ala 
        355             


<210>  99
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  99-Wnt7a_K255A F-Primer

<400>  99
cggcccacct tcctgaagat cgcgaagcca ctgtcgtacc gcaag                       45


<210>  100
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  100-Wnt7a_K255A R-Primer

<400>  100
cttgcggtac gacagtggct tcgcgatctt caggaaggtg ggccg                       45


<210>  101
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  101-Wnt7a_K256A

<400>  101

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys Ala 
                245                 250                 255     


Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile Glu 
            260                 265                 270         


Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly 
        275                 280                 285             


Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys 
    290                 295                 300                 


Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg 
305                 310                 315                 320 


Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys 
                325                 330                 335     


Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr 
            340                 345                 350         


Asp Val Pro Asp Tyr Ala 
        355             


<210>  102
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  102-Wnt7a_K256A F-Primer

<400>  102
caccttcctg aagatcaagg cgccactgtc gtaccgcaag ccc                         43


<210>  103
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  103-Wnt7a_K256A R-Primer

<400>  103
gggcttgcgg tacgacagtg gcgccttgat cttcaggaag gtg                         43


<210>  104
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  104-Wnt7a_DeltaESP*Wnt10a-ESP

<400>  104

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


His Asn Arg Asn Gly Gly Gln Leu Glu Pro Gly Pro Ala Gly Ala Pro 
                245                 250                 255     


Ser Pro Ala Pro Gly Ala Pro Gly Pro Arg Arg Arg Ala Ser Asp Thr 
            260                 265                 270         


Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro 
        275                 280                 285             


Val Thr Gly Ser Val Gly Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala 
    290                 295                 300                 


Pro Gln Ala Ser Gly Cys Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn 
305                 310                 315                 320 


Thr His Gln Tyr Ala Arg Val Trp Gln Cys Asn Cys Lys Phe His Trp 
                325                 330                 335     


Cys Cys Tyr Val Lys Cys Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr 
            340                 345                 350         


Thr Cys Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
        355                 360                 


<210>  105
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  105-Wnt7a_DeltaESP*Wnt10a-ESP F1-Primer

<400>  105
aaggatccac catgaaccgg aaagcgcggc gctg                                   34


<210>  106
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  106-Wnt7a_DeltaESP*Wnt10a-ESP F2-Primer

<400>  106
gctccgggcg ctcccgggcc gcgccgacgg gccagcgaca cggacctggt gtacatc          57


<210>  107
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  107-Wnt7a_DeltaESP*Wnt10a-ESP F3-Primer

<400>  107
ctggagccgg gcccagcggg ggcaccctcg ccggctccgg gcgctcccgg gccg             54


<210>  108
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  108-Wnt7a_DeltaESP*Wnt10a-ESP R1-Primer

<400>  108
tgggcccggc tccagctggc cgccgttgcg gttgtgaggc tccacgtgaa cggcctc          57


<210>  109
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  109-Wnt7a_DeltaESP*Wnt10a-ESP R2-Primer

<400>  109
aagaattctc aagcgtaatc tggaacatcg tatgggtact tgcacgtgta catctccg         58


<210>  110
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  110-Wnt7a_DeltaESP*Wnt16-ESP

<400>  110

Met Asn Arg Lys Ala Arg Arg Cys Leu Gly His Leu Phe Leu Ser Leu 
1               5                   10                  15      


Gly Met Val Tyr Leu Arg Ile Gly Gly Phe Ser Ser Val Val Ala Leu 
            20                  25                  30          


Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg Gln 
        35                  40                  45              


Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly Glu 
    50                  55                  60                  


Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn Gly 
65                  70                  75                  80  


Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys Glu 
                85                  90                  95      


Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile Ala 
            100                 105                 110         


Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn Leu 
        115                 120                 125             


Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg Asp 
    130                 135                 140                 


Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly Ile 
145                 150                 155                 160 


Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn Ala 
                165                 170                 175     


Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile Leu 
            180                 185                 190         


Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu Leu 
    210                 215                 220                 


Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu Pro 
225                 230                 235                 240 


Lys Thr Lys Arg Lys Met Arg Arg Arg Glu Lys Asp Gln Arg Lys Ile 
                245                 250                 255     


Pro Ile His Asp Thr Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn Tyr 
            260                 265                 270         


Cys Glu Glu Asp Pro Val Thr Gly Ser Val Gly Thr Gln Gly Arg Ala 
        275                 280                 285             


Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly Cys Asp Leu Met Cys Cys 
    290                 295                 300                 


Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala Arg Val Trp Gln Cys Asn 
305                 310                 315                 320 


Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Asn Thr Cys Ser Glu 
                325                 330                 335     


Arg Thr Glu Met Tyr Thr Cys Lys Tyr Pro Tyr Asp Val Pro Asp Tyr 
            340                 345                 350         


Ala 
    


<210>  111
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  111-Wnt7a_DeltaESP*Wnt16-ESP F1-Primer

<400>  111
aaggatccac catgaaccgg aaagcgcggc gctg                                   34


<210>  112
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  112-Wnt7a_DeltaESP*Wnt16-ESP F2-Primer

<400>  112
aggagagaaa aagatcagag gaaaatacca atccatgaca cggacctggt gtacatc          57


<210>  113
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  113-Wnt7a_DeltaESP*Wnt16-ESP R1-Primer

<400>  113
atctttttct ctcctgcgca ttttcctctt tgttttaggc tccacgtgaa cggcctc          57


<210>  114
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  114-Wnt7a_DeltaESP*Wnt16-ESP R2-Primer

<400>  114
aagaattctc aagcgtaatc tggaacatcg tatgggtact tgcacgtgta catctccg         58


<210>  115
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  115-Wnt10b_DeltaESP*GSGS

<400>  115

Met Leu Glu Glu Pro Arg Pro Arg Pro Pro Pro Ser Gly Leu Ala Gly 
1               5                   10                  15      


Leu Leu Phe Leu Ala Leu Cys Ser Arg Ala Leu Ser Asn Glu Ile Leu 
            20                  25                  30          


Gly Leu Lys Leu Pro Gly Glu Pro Pro Leu Thr Ala Asn Thr Val Cys 
        35                  40                  45              


Leu Thr Leu Ser Gly Leu Ser Lys Arg Gln Leu Gly Leu Cys Leu Arg 
    50                  55                  60                  


Asn Pro Asp Val Thr Ala Ser Ala Leu Gln Gly Leu His Ile Ala Val 
65                  70                  75                  80  


His Glu Cys Gln His Gln Leu Arg Asp Gln Arg Trp Asn Cys Ser Ala 
                85                  90                  95      


Leu Glu Gly Gly Gly Arg Leu Pro His His Ser Ala Ile Leu Lys Arg 
            100                 105                 110         


Gly Phe Arg Glu Ser Ala Phe Ser Phe Ser Met Leu Ala Ala Gly Val 
        115                 120                 125             


Met His Ala Val Ala Thr Ala Cys Ser Leu Gly Lys Leu Val Ser Cys 
    130                 135                 140                 


Gly Cys Gly Trp Lys Gly Ser Gly Glu Gln Asp Arg Leu Arg Ala Lys 
145                 150                 155                 160 


Leu Leu Gln Leu Gln Ala Leu Ser Arg Gly Lys Ser Phe Pro His Ser 
                165                 170                 175     


Leu Pro Ser Pro Gly Pro Gly Ser Ser Pro Ser Pro Gly Pro Gln Asp 
            180                 185                 190         


Thr Trp Glu Trp Gly Gly Cys Asn His Asp Met Asp Phe Gly Glu Lys 
        195                 200                 205             


Phe Ser Arg Asp Phe Leu Asp Ser Arg Glu Ala Pro Arg Asp Ile Gln 
    210                 215                 220                 


Ala Arg Met Arg Ile His Asn Asn Arg Val Gly Arg Gln Val Val Thr 
225                 230                 235                 240 


Glu Asn Leu Lys Arg Lys Cys Lys Cys His Gly Thr Ser Gly Ser Cys 
                245                 250                 255     


Gln Phe Lys Thr Cys Trp Arg Ala Ala Pro Glu Phe Arg Ala Val Gly 
            260                 265                 270         


Ala Ala Leu Arg Glu Arg Leu Gly Arg Ala Ile Phe Ile Gly Ser Gly 
        275                 280                 285             


Ser Glu Leu Val Tyr Phe Glu Lys Ser Pro Asp Phe Cys Glu Arg Asp 
    290                 295                 300                 


Pro Thr Met Gly Ser Pro Gly Thr Arg Gly Arg Ala Cys Asn Lys Thr 
305                 310                 315                 320 


Ser Arg Leu Leu Asp Gly Cys Gly Ser Leu Cys Cys Gly Arg Gly His 
                325                 330                 335     


Asn Val Leu Arg Gln Thr Arg Val Glu Arg Cys His Cys Arg Phe His 
            340                 345                 350         


Trp Cys Cys Tyr Val Leu Cys Asp Glu Cys Lys Val Thr Glu Trp Val 
        355                 360                 365             


Asn Val Cys Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
    370                 375                 380     


<210>  116
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  116-Wnt10b_DeltaESP*GSGS F1-Primer

<400>  116
aaggatccac catgctggag gagccccggc c                                      31


<210>  117
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  117-Wnt10b_DeltaESP*GSGS F2-Primer

<400>  117
cggctgggcc gggccatctt cattggttca ggttcagagc tggtctactt tgagaagtct       60

c                                                                       61


<210>  118
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  118-Wnt10b_DeltaESP*GSGS R1-Primer

<400>  118
gagacttctc aaagtagacc agctctgaac ctgaaccaat gaagatggcc cggcccagcc       60

g                                                                       61


<210>  119
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  119-Wnt10b_DeltaESP*GSGS R2-Primer

<400>  119
aagaattcct aaccggtacg cgtagaatcg                                        30


<210>  120
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  120-Wnt10b_RR302AA

<400>  120

Met Leu Glu Glu Pro Arg Pro Arg Pro Pro Pro Ser Gly Leu Ala Gly 
1               5                   10                  15      


Leu Leu Phe Leu Ala Leu Cys Ser Arg Ala Leu Ser Asn Glu Ile Leu 
            20                  25                  30          


Gly Leu Lys Leu Pro Gly Glu Pro Pro Leu Thr Ala Asn Thr Val Cys 
        35                  40                  45              


Leu Thr Leu Ser Gly Leu Ser Lys Arg Gln Leu Gly Leu Cys Leu Arg 
    50                  55                  60                  


Asn Pro Asp Val Thr Ala Ser Ala Leu Gln Gly Leu His Ile Ala Val 
65                  70                  75                  80  


His Glu Cys Gln His Gln Leu Arg Asp Gln Arg Trp Asn Cys Ser Ala 
                85                  90                  95      


Leu Glu Gly Gly Gly Arg Leu Pro His His Ser Ala Ile Leu Lys Arg 
            100                 105                 110         


Gly Phe Arg Glu Ser Ala Phe Ser Phe Ser Met Leu Ala Ala Gly Val 
        115                 120                 125             


Met His Ala Val Ala Thr Ala Cys Ser Leu Gly Lys Leu Val Ser Cys 
    130                 135                 140                 


Gly Cys Gly Trp Lys Gly Ser Gly Glu Gln Asp Arg Leu Arg Ala Lys 
145                 150                 155                 160 


Leu Leu Gln Leu Gln Ala Leu Ser Arg Gly Lys Ser Phe Pro His Ser 
                165                 170                 175     


Leu Pro Ser Pro Gly Pro Gly Ser Ser Pro Ser Pro Gly Pro Gln Asp 
            180                 185                 190         


Thr Trp Glu Trp Gly Gly Cys Asn His Asp Met Asp Phe Gly Glu Lys 
        195                 200                 205             


Phe Ser Arg Asp Phe Leu Asp Ser Arg Glu Ala Pro Arg Asp Ile Gln 
    210                 215                 220                 


Ala Arg Met Arg Ile His Asn Asn Arg Val Gly Arg Gln Val Val Thr 
225                 230                 235                 240 


Glu Asn Leu Lys Arg Lys Cys Lys Cys His Gly Thr Ser Gly Ser Cys 
                245                 250                 255     


Gln Phe Lys Thr Cys Trp Arg Ala Ala Pro Glu Phe Arg Ala Val Gly 
            260                 265                 270         


Ala Ala Leu Arg Glu Arg Leu Gly Arg Ala Ile Phe Ile Asp Thr His 
        275                 280                 285             


Asn Arg Asn Ser Gly Ala Phe Gln Pro Arg Leu Arg Pro Ala Ala Leu 
    290                 295                 300                 


Ser Gly Glu Leu Val Tyr Phe Glu Lys Ser Pro Asp Phe Cys Glu Arg 
305                 310                 315                 320 


Asp Pro Thr Met Gly Ser Pro Gly Thr Arg Gly Arg Ala Cys Asn Lys 
                325                 330                 335     


Thr Ser Arg Leu Leu Asp Gly Cys Gly Ser Leu Cys Cys Gly Arg Gly 
            340                 345                 350         


His Asn Val Leu Arg Gln Thr Arg Val Glu Arg Cys His Cys Arg Phe 
        355                 360                 365             


His Trp Cys Cys Tyr Val Leu Cys Asp Glu Cys Lys Val Thr Glu Trp 
    370                 375                 380                 


Val Asn Val Cys Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
385                 390                 395             


<210>  121
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  121-Wnt10b_RR302AA F-Primer

<400>  121
gccttccagc cccgtctgcg tcccgctgcc ctctcaggag agctggtcta ctttg            55


<210>  122
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  122-Wnt10b_RR302AA R-Primer

<400>  122
caaagtagac cagctctcct gagagggcag cgggacgcag acggggctgg aaggc            55


