                         SEQUENCE LISTING

<110>  UNIVERSITE LAVAL
 
<120>  VIRAL RNA POLYMERASE INHIBITORS AND USES THEREOF

<130>  G11229-00452

<150>  US 63/183,208
<151>  2021-05-03

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  932
<212>  PRT
<213>  SARS-CoV-2

<400>  1

Ser Ala Asp Ala Gln Ser Phe Leu Asn Arg Val Cys Gly Val Ser Ala 
1               5                   10                  15      


Ala Arg Leu Thr Pro Cys Gly Thr Gly Thr Ser Thr Asp Val Val Tyr 
            20                  25                  30          


Arg Ala Phe Asp Ile Tyr Asn Asp Lys Val Ala Gly Phe Ala Lys Phe 
        35                  40                  45              


Leu Lys Thr Asn Cys Cys Arg Phe Gln Glu Lys Asp Glu Asp Asp Asn 
    50                  55                  60                  


Leu Ile Asp Ser Tyr Phe Val Val Lys Arg His Thr Phe Ser Asn Tyr 
65                  70                  75                  80  


Gln His Glu Glu Thr Ile Tyr Asn Leu Leu Lys Asp Cys Pro Ala Val 
                85                  90                  95      


Ala Lys His Asp Phe Phe Lys Phe Arg Ile Asp Gly Asp Met Val Pro 
            100                 105                 110         


His Ile Ser Arg Gln Arg Leu Thr Lys Tyr Thr Met Ala Asp Leu Val 
        115                 120                 125             


Tyr Ala Leu Arg His Phe Asp Glu Gly Asn Cys Asp Thr Leu Lys Glu 
    130                 135                 140                 


Ile Leu Val Thr Tyr Asn Cys Cys Asp Asp Asp Tyr Phe Asn Lys Lys 
145                 150                 155                 160 


Asp Trp Tyr Asp Phe Val Glu Asn Pro Asp Ile Leu Arg Val Tyr Ala 
                165                 170                 175     


Asn Leu Gly Glu Arg Val Arg Gln Ala Leu Leu Lys Thr Val Gln Phe 
            180                 185                 190         


Cys Asp Ala Met Arg Asn Ala Gly Ile Val Gly Val Leu Thr Leu Asp 
        195                 200                 205             


Asn Gln Asp Leu Asn Gly Asn Trp Tyr Asp Phe Gly Asp Phe Ile Gln 
    210                 215                 220                 


Thr Thr Pro Gly Ser Gly Val Pro Val Val Asp Ser Tyr Tyr Ser Leu 
225                 230                 235                 240 


Leu Met Pro Ile Leu Thr Leu Thr Arg Ala Leu Thr Ala Glu Ser His 
                245                 250                 255     


Val Asp Thr Asp Leu Thr Lys Pro Tyr Ile Lys Trp Asp Leu Leu Lys 
            260                 265                 270         


Tyr Asp Phe Thr Glu Glu Arg Leu Lys Leu Phe Asp Arg Tyr Phe Lys 
        275                 280                 285             


Tyr Trp Asp Gln Thr Tyr His Pro Asn Cys Val Asn Cys Leu Asp Asp 
    290                 295                 300                 


Arg Cys Ile Leu His Cys Ala Asn Phe Asn Val Leu Phe Ser Thr Val 
305                 310                 315                 320 


Phe Pro Pro Thr Ser Phe Gly Pro Leu Val Arg Lys Ile Phe Val Asp 
                325                 330                 335     


Gly Val Pro Phe Val Val Ser Thr Gly Tyr His Phe Arg Glu Leu Gly 
            340                 345                 350         


Val Val His Asn Gln Asp Val Asn Leu His Ser Ser Arg Leu Ser Phe 
        355                 360                 365             


Lys Glu Leu Leu Val Tyr Ala Ala Asp Pro Ala Met His Ala Ala Ser 
    370                 375                 380                 


Gly Asn Leu Leu Leu Asp Lys Arg Thr Thr Cys Phe Ser Val Ala Ala 
385                 390                 395                 400 


Leu Thr Asn Asn Val Ala Phe Gln Thr Val Lys Pro Gly Asn Phe Asn 
                405                 410                 415     


Lys Asp Phe Tyr Asp Phe Ala Val Ser Lys Gly Phe Phe Lys Glu Gly 
            420                 425                 430         


Ser Ser Val Glu Leu Lys His Phe Phe Phe Ala Gln Asp Gly Asn Ala 
        435                 440                 445             


Ala Ile Ser Asp Tyr Asp Tyr Tyr Arg Tyr Asn Leu Pro Thr Met Cys 
    450                 455                 460                 


Asp Ile Arg Gln Leu Leu Phe Val Val Glu Val Val Asp Lys Tyr Phe 
465                 470                 475                 480 


Asp Cys Tyr Asp Gly Gly Cys Ile Asn Ala Asn Gln Val Ile Val Asn 
                485                 490                 495     


Asn Leu Asp Lys Ser Ala Gly Phe Pro Phe Asn Lys Trp Gly Lys Ala 
            500                 505                 510         


Arg Leu Tyr Tyr Asp Ser Met Ser Tyr Glu Asp Gln Asp Ala Leu Phe 
        515                 520                 525             


Ala Tyr Thr Lys Arg Asn Val Ile Pro Thr Ile Thr Gln Met Asn Leu 
    530                 535                 540                 


Lys Tyr Ala Ile Ser Ala Lys Asn Arg Ala Arg Thr Val Ala Gly Val 
545                 550                 555                 560 


Ser Ile Cys Ser Thr Met Thr Asn Arg Gln Phe His Gln Lys Leu Leu 
                565                 570                 575     


Lys Ser Ile Ala Ala Thr Arg Gly Ala Thr Val Val Ile Gly Thr Ser 
            580                 585                 590         


Lys Phe Tyr Gly Gly Trp His Asn Met Leu Lys Thr Val Tyr Ser Asp 
        595                 600                 605             


Val Glu Asn Pro His Leu Met Gly Trp Asp Tyr Pro Lys Cys Asp Arg 
    610                 615                 620                 


Ala Met Pro Asn Met Leu Arg Ile Met Ala Ser Leu Val Leu Ala Arg 
625                 630                 635                 640 


Lys His Thr Thr Cys Cys Ser Leu Ser His Arg Phe Tyr Arg Leu Ala 
                645                 650                 655     


Asn Glu Cys Ala Gln Val Leu Ser Glu Met Val Met Cys Gly Gly Ser 
            660                 665                 670         


Leu Tyr Val Lys Pro Gly Gly Thr Ser Ser Gly Asp Ala Thr Thr Ala 
        675                 680                 685             


Tyr Ala Asn Ser Val Phe Asn Ile Cys Gln Ala Val Thr Ala Asn Val 
    690                 695                 700                 


Asn Ala Leu Leu Ser Thr Asp Gly Asn Lys Ile Ala Asp Lys Tyr Val 
705                 710                 715                 720 


Arg Asn Leu Gln His Arg Leu Tyr Glu Cys Leu Tyr Arg Asn Arg Asp 
                725                 730                 735     


Val Asp Thr Asp Phe Val Asn Glu Phe Tyr Ala Tyr Leu Arg Lys His 
            740                 745                 750         


Phe Ser Met Met Ile Leu Ser Asp Asp Ala Val Val Cys Phe Asn Ser 
        755                 760                 765             


Thr Tyr Ala Ser Gln Gly Leu Val Ala Ser Ile Lys Asn Phe Lys Ser 
    770                 775                 780                 


Val Leu Tyr Tyr Gln Asn Asn Val Phe Met Ser Glu Ala Lys Cys Trp 
785                 790                 795                 800 


Thr Glu Thr Asp Leu Thr Lys Gly Pro His Glu Phe Cys Ser Gln His 
                805                 810                 815     


Thr Met Leu Val Lys Gln Gly Asp Asp Tyr Val Tyr Leu Pro Tyr Pro 
            820                 825                 830         


Asp Pro Ser Arg Ile Leu Gly Ala Gly Cys Phe Val Asp Asp Ile Val 
        835                 840                 845             


Lys Thr Asp Gly Thr Leu Met Ile Glu Arg Phe Val Ser Leu Ala Ile 
    850                 855                 860                 


Asp Ala Tyr Pro Leu Thr Lys His Pro Asn Gln Glu Tyr Ala Asp Val 
865                 870                 875                 880 


Phe His Leu Tyr Leu Gln Tyr Ile Arg Lys Leu His Asp Glu Leu Thr 
                885                 890                 895     


Gly His Met Leu Asp Met Tyr Ser Val Met Leu Thr Asn Asp Asn Thr 
            900                 905                 910         


Ser Arg Tyr Trp Glu Pro Glu Phe Tyr Glu Ala Met Tyr Thr Pro His 
        915                 920                 925             


Thr Val Leu Gln 
    930         


<210>  2
<211>  928
<212>  PRT
<213>  SARS-CoV-2

<400>  2

Gln Ser Phe Leu Asn Arg Val Cys Gly Val Ser Ala Ala Arg Leu Thr 
1               5                   10                  15      


Pro Cys Gly Thr Gly Thr Ser Thr Asp Val Val Tyr Arg Ala Phe Asp 
            20                  25                  30          


Ile Tyr Asn Asp Lys Val Ala Gly Phe Ala Lys Phe Leu Lys Thr Asn 
        35                  40                  45              


Cys Cys Arg Phe Gln Glu Lys Asp Glu Asp Asp Asn Leu Ile Asp Ser 
    50                  55                  60                  


Tyr Phe Val Val Lys Arg His Thr Phe Ser Asn Tyr Gln His Glu Glu 
65                  70                  75                  80  


Thr Ile Tyr Asn Leu Leu Lys Asp Cys Pro Ala Val Ala Lys His Asp 
                85                  90                  95      


Phe Phe Lys Phe Arg Ile Asp Gly Asp Met Val Pro His Ile Ser Arg 
            100                 105                 110         


Gln Arg Leu Thr Lys Tyr Thr Met Ala Asp Leu Val Tyr Ala Leu Arg 
        115                 120                 125             


His Phe Asp Glu Gly Asn Cys Asp Thr Leu Lys Glu Ile Leu Val Thr 
    130                 135                 140                 


Tyr Asn Cys Cys Asp Asp Asp Tyr Phe Asn Lys Lys Asp Trp Tyr Asp 
145                 150                 155                 160 


Phe Val Glu Asn Pro Asp Ile Leu Arg Val Tyr Ala Asn Leu Gly Glu 
                165                 170                 175     


Arg Val Arg Gln Ala Leu Leu Lys Thr Val Gln Phe Cys Asp Ala Met 
            180                 185                 190         


Arg Asn Ala Gly Ile Val Gly Val Leu Thr Leu Asp Asn Gln Asp Leu 
        195                 200                 205             


Asn Gly Asn Trp Tyr Asp Phe Gly Asp Phe Ile Gln Thr Thr Pro Gly 
    210                 215                 220                 


Ser Gly Val Pro Val Val Asp Ser Tyr Tyr Ser Leu Leu Met Pro Ile 
225                 230                 235                 240 


Leu Thr Leu Thr Arg Ala Leu Thr Ala Glu Ser His Val Asp Thr Asp 
                245                 250                 255     


Leu Thr Lys Pro Tyr Ile Lys Trp Asp Leu Leu Lys Tyr Asp Phe Thr 
            260                 265                 270         


Glu Glu Arg Leu Lys Leu Phe Asp Arg Tyr Phe Lys Tyr Trp Asp Gln 
        275                 280                 285             


Thr Tyr His Pro Asn Cys Val Asn Cys Leu Asp Asp Arg Cys Ile Leu 
    290                 295                 300                 


His Cys Ala Asn Phe Asn Val Leu Phe Ser Thr Val Phe Pro Pro Thr 
305                 310                 315                 320 


Ser Phe Gly Pro Leu Val Arg Lys Ile Phe Val Asp Gly Val Pro Phe 
                325                 330                 335     


Val Val Ser Thr Gly Tyr His Phe Arg Glu Leu Gly Val Val His Asn 
            340                 345                 350         


Gln Asp Val Asn Leu His Ser Ser Arg Leu Ser Phe Lys Glu Leu Leu 
        355                 360                 365             


Val Tyr Ala Ala Asp Pro Ala Met His Ala Ala Ser Gly Asn Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Thr Thr Cys Phe Ser Val Ala Ala Leu Thr Asn Asn 
385                 390                 395                 400 


Val Ala Phe Gln Thr Val Lys Pro Gly Asn Phe Asn Lys Asp Phe Tyr 
                405                 410                 415     


Asp Phe Ala Val Ser Lys Gly Phe Phe Lys Glu Gly Ser Ser Val Glu 
            420                 425                 430         


Leu Lys His Phe Phe Phe Ala Gln Asp Gly Asn Ala Ala Ile Ser Asp 
        435                 440                 445             


Tyr Asp Tyr Tyr Arg Tyr Asn Leu Pro Thr Met Cys Asp Ile Arg Gln 
    450                 455                 460                 


Leu Leu Phe Val Val Glu Val Val Asp Lys Tyr Phe Asp Cys Tyr Asp 
465                 470                 475                 480 


Gly Gly Cys Ile Asn Ala Asn Gln Val Ile Val Asn Asn Leu Asp Lys 
                485                 490                 495     


Ser Ala Gly Phe Pro Phe Asn Lys Trp Gly Lys Ala Arg Leu Tyr Tyr 
            500                 505                 510         


Asp Ser Met Ser Tyr Glu Asp Gln Asp Ala Leu Phe Ala Tyr Thr Lys 
        515                 520                 525             


Arg Asn Val Ile Pro Thr Ile Thr Gln Met Asn Leu Lys Tyr Ala Ile 
    530                 535                 540                 


Ser Ala Lys Asn Arg Ala Arg Thr Val Ala Gly Val Ser Ile Cys Ser 
545                 550                 555                 560 


Thr Met Thr Asn Arg Gln Phe His Gln Lys Leu Leu Lys Ser Ile Ala 
                565                 570                 575     


Ala Thr Arg Gly Ala Thr Val Val Ile Gly Thr Ser Lys Phe Tyr Gly 
            580                 585                 590         


Gly Trp His Asn Met Leu Lys Thr Val Tyr Ser Asp Val Glu Asn Pro 
        595                 600                 605             


His Leu Met Gly Trp Asp Tyr Pro Lys Cys Asp Arg Ala Met Pro Asn 
    610                 615                 620                 


Met Leu Arg Ile Met Ala Ser Leu Val Leu Ala Arg Lys His Thr Thr 
625                 630                 635                 640 


Cys Cys Ser Leu Ser His Arg Phe Tyr Arg Leu Ala Asn Glu Cys Ala 
                645                 650                 655     


Gln Val Leu Ser Glu Met Val Met Cys Gly Gly Ser Leu Tyr Val Lys 
            660                 665                 670         


Pro Gly Gly Thr Ser Ser Gly Asp Ala Thr Thr Ala Tyr Ala Asn Ser 
        675                 680                 685             


Val Phe Asn Ile Cys Gln Ala Val Thr Ala Asn Val Asn Ala Leu Leu 
    690                 695                 700                 


Ser Thr Asp Gly Asn Lys Ile Ala Asp Lys Tyr Val Arg Asn Leu Gln 
705                 710                 715                 720 


His Arg Leu Tyr Glu Cys Leu Tyr Arg Asn Arg Asp Val Asp Thr Asp 
                725                 730                 735     


Phe Val Asn Glu Phe Tyr Ala Tyr Leu Arg Lys His Phe Ser Met Met 
            740                 745                 750         


Ile Leu Ser Asp Asp Ala Val Val Cys Phe Asn Ser Thr Tyr Ala Ser 
        755                 760                 765             


Gln Gly Leu Val Ala Ser Ile Lys Asn Phe Lys Ser Val Leu Tyr Tyr 
    770                 775                 780                 


Gln Asn Asn Val Phe Met Ser Glu Ala Lys Cys Trp Thr Glu Thr Asp 
785                 790                 795                 800 


Leu Thr Lys Gly Pro His Glu Phe Cys Ser Gln His Thr Met Leu Val 
                805                 810                 815     


Lys Gln Gly Asp Asp Tyr Val Tyr Leu Pro Tyr Pro Asp Pro Ser Arg 
            820                 825                 830         


Ile Leu Gly Ala Gly Cys Phe Val Asp Asp Ile Val Lys Thr Asp Gly 
        835                 840                 845             


Thr Leu Met Ile Glu Arg Phe Val Ser Leu Ala Ile Asp Ala Tyr Pro 
    850                 855                 860                 


Leu Thr Lys His Pro Asn Gln Glu Tyr Ala Asp Val Phe His Leu Tyr 
865                 870                 875                 880 


Leu Gln Tyr Ile Arg Lys Leu His Asp Glu Leu Thr Gly His Met Leu 
                885                 890                 895     


Asp Met Tyr Ser Val Met Leu Thr Asn Asp Asn Thr Ser Arg Tyr Trp 
            900                 905                 910         


Glu Pro Glu Phe Tyr Glu Ala Met Tyr Thr Pro His Thr Val Leu Gln 
        915                 920                 925             


