                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  LASSA VIRUS-SPECIFIC NANOBODIES AND METHODS OF THEIR USE

<130>  4239-106147-02

<150>  US 63/181,519
<151>  2021-04-29

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Ala Trp Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Gln Ala Ser Lys Ser Thr Phe Ser Thr Ser 
            20                  25                  30          


Gly Met Arg Trp Glu Arg Gln Ala Gln Gly Lys Gly Val Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Ser Ser Asp Ser Thr Arg Lys Trp Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Ser Asn Trp Trp Arg Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      


Lys Asp Leu Glu Ser His His Leu Arg Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Ala Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asn Ser Asp Cys Gly Leu Ser 
            20                  25                  30          


Asp Thr Tyr Trp Phe Arg Met Ser Pro Gly Ser Gly Ser Glu Glu Arg 
        35                  40                  45              


Ile Ser Ile Gly Gly Arg Tyr Leu Glu Thr Val Asn Ser Val Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Arg 
65                  70                  75                  80  


Tyr Arg Cys Lys Thr Asp Val Tyr Arg Tyr Val Ser Gly Ser Gly Cys 
                85                  90                  95      


Leu Tyr Ser Tyr Phe Ala Ser Gly Ala Gly Thr Val Val Thr Val Asn 
            100                 105                 110         


<210>  3
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Pro Pro Asp Ser Asn Cys Ala Leu Ala 
            20                  25                  30          


Asp Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Pro Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ile Leu Arg Ile Asn Asp Leu Arg Val Ala Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Val Ser Cys Tyr Ala Ala Ala Tyr Tyr Gly Gln Gln 
                85                  90                  95      


Leu Glu Arg Leu Tyr Asp Val Tyr Gly Gly Gly Thr Ala Val Thr Val 
            100                 105                 110         


Asn 
    


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Thr Cys Ile Leu Arg Asp Ser Gln Cys Ala Leu Ser 
            20                  25                  30          


Pro Thr Tyr Trp Tyr His Lys Lys Ser Gly Ser Thr Lys Pro Glu Arg 
        35                  40                  45              


Ile Tyr Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Phe Phe Cys Lys Val Ser Gly Trp Tyr Ala Tyr Ser Cys Arg Leu Glu 
                85                  90                  95      


Pro Asp Gly Tyr Tyr Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val 
            100                 105                 110         


Asn 
    


<210>  5
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Ala Arg Val Asp Gln Thr Pro Gln Thr Val Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Ala Leu Pro 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Asn 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Arg Pro Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Val His Gly Leu Pro Leu Asp Cys Ile Pro Ala Arg 
                85                  90                  95      


Gly Leu Glu Leu Asn Trp Arg Glu Asp Val Asn Gly Gly Gly Thr Ala 
            100                 105                 110         


Val Thr Val Asn 
        115     


<210>  6
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Pro Leu Ser 
            20                  25                  30          


Ser Thr Phe Trp Tyr Arg Ala Asp Ala Gly Ser Leu Asn Glu Glu Asn 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Thr Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Val Ala Gly Leu Pro Leu Asp Cys Ile Pro Ala Arg 
                85                  90                  95      


Gly Leu Glu Leu Asn Trp Arg Glu Asp Val Tyr Gly Gly Gly Thr Ala 
            100                 105                 110         


Val Thr Val Asn 
        115     


<210>  7
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Glu Pro Lys Ile Pro Gln Pro Gln Pro Lys Pro Gln Pro Gln Pro Gln 
1               5                   10                  15      


Pro Gln Pro Lys Pro Gln Pro Lys Pro Glu Pro Glu Cys Thr Cys Pro 
            20                  25                  30          


Lys Cys Pro 
        35  


<210>  8
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Gly Gln Ile Val Thr Phe Phe Gln Glu Val Pro His Val Ile Glu 
1               5                   10                  15      


Glu Val Met Asn Ile Val Leu Ile Ala Leu Ser Val Leu Ala Val Leu 
            20                  25                  30          


Lys Gly Leu Tyr Asn Phe Ala Thr Cys Gly Leu Val Gly Leu Val Thr 
        35                  40                  45              


Phe Leu Leu Leu Cys Gly Arg Ser Cys Thr Thr Ser Leu Tyr Lys Gly 
    50                  55                  60                  


Val Tyr Glu Leu Gln Thr Leu Glu Leu Asn Met Glu Thr Leu Asn Met 
65                  70                  75                  80  


Thr Met Pro Leu Ser Cys Thr Lys Asn Asn Ser His His Tyr Ile Met 
                85                  90                  95      


Val Gly Asn Glu Thr Gly Leu Glu Leu Thr Leu Thr Asn Thr Ser Ile 
            100                 105                 110         


Ile Asn His Lys Phe Cys Asn Leu Ser Asp Ala His Lys Lys Asn Leu 
        115                 120                 125             


Tyr Asp His Ala Leu Met Ser Ile Ile Ser Thr Phe His Leu Ser Ile 
    130                 135                 140                 


Pro Asn Phe Asn Gln Tyr Glu Ala Met Ser Cys Asp Phe Asn Gly Gly 
145                 150                 155                 160 


Lys Ile Ser Val Gln Tyr Asn Leu Ser His Ser Tyr Ala Gly Asp Ala 
                165                 170                 175     


Ala Asn His Cys Gly Thr Val Ala Asn Gly Val Leu Gln Thr Phe Met 
            180                 185                 190         


Arg Met Ala Trp Gly Gly Ser Tyr Ile Ala Leu Asp Ser Gly Gly Cys 
        195                 200                 205             


Gly Asn Trp Asp Cys Ile Met Thr Ser Tyr Gln Tyr Leu Ile Ile Gln 
    210                 215                 220                 


Asn Thr Thr Trp Glu Asp His Cys Gln Phe Ser Arg Pro Ser Pro Ile 
225                 230                 235                 240 


Gly Tyr Leu Gly Leu Leu Ser Gln Arg Thr Arg Asp Ile Tyr Ile Ser 
                245                 250                 255     


Arg Arg Arg Arg Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Glu Gly 
            260                 265                 270         


Lys Asp Thr Pro Gly Gly Tyr Cys Leu Thr Arg Trp Met Leu Ile Glu 
        275                 280                 285             


Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Glu 
    290                 295                 300                 


Lys His Asp Glu Glu Phe Cys Asp Met Leu Arg Leu Phe Asp Phe Asn 
305                 310                 315                 320 


Lys Gln Ala Ile Gln Arg Cys Lys Ala Pro Ala Gln Met Ser Ile Gln 
                325                 330                 335     


Leu Ile Asn Lys Ala Val Asn Ala Leu Ile Asn Asp Gln Leu Ile Met 
            340                 345                 350         


Lys Asn His Leu Arg Asp Ile Met Gly Ile Pro Tyr Cys Asn Tyr Ser 
        355                 360                 365             


Lys Tyr Trp Tyr Leu Asn His Thr Thr Thr Gly Arg Thr Ser Leu Pro 
    370                 375                 380                 


Lys Cys Trp Leu Val Ser Asn Gly Ser Tyr Leu Asn Glu Thr His Phe 
385                 390                 395                 400 


Ser Asp Asp Ile Glu Gln Gln Ala Asp Asn Met Ile Thr Glu Met Leu 
                405                 410                 415     


Gln Lys Glu Gly Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
            420                 425                 430         


Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
        435                 440                 445             


Gly Gly Leu Val Pro Arg 
    450                 


<210>  9
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  9
gcgtggcagc tggtggagtc tgggggaggc tcggtgcagc cggggggctc tctgacactc       60

acctgtcaag cttccaaatc tacgttcagt acgtccggca tgcggtggga gcgccaggct      120

caagggaagg gagtggaatt tgtcgcagat attagtagtg atagtacgag gaaatggtat      180

tcagactccg tgaagggccg attcacgatc tccagaagca actggtggag gacggtgact      240

ctacagatga acgatctgaa acctgaggac acggcccgtt attattgtaa agatcttgag      300

tcccaccatc tacggggcca ggggacccag gtcaccgtct cctca                      345


