                         SEQUENCE LISTING

<110>  AMGEN INC.
       AMGEN RESEARCH (MUNICH) GMBH
 
<120>  METHODS FOR REDUCING LOW MOLECULAR WEIGHT SPECIES OF 
       RECOMBINANTLY-PRODUCED PROTEINS

<130>  A-2734-WO01-SEC

<150>  63/181,903
<151>  2021-04-29

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Asp Gly Gly Tyr Tyr Thr Tyr Tyr Ser Asp Ile Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Pro Leu Leu Arg His Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
145                 150                 155                 160 


Ala Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Lys Ser Leu Ile Tyr Ser Ala Ser Tyr Val Tyr Trp 
            180                 185                 190         


Asp Val Pro Ser Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asp Gln Gln Leu Ile Thr Phe Gly Cys Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr 
    290                 295                 300                 


Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn 
                325                 330                 335     


Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn 
            340                 345                 350         


Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr 
385                 390                 395                 400 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly 
                405                 410                 415     


Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly 
            420                 425                 430         


Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly 
        435                 440                 445             


Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu 
    450                 455                 460                 


Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val 
465                 470                 475                 480 


Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                485                 490                 495     


Val Leu Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            500                 505                 510         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        515                 520                 525             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    530                 535                 540                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
545                 550                 555                 560 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
                565                 570                 575     


Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
            580                 585                 590         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        595                 600                 605             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    610                 615                 620                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
625                 630                 635                 640 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                645                 650                 655     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            660                 665                 670         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        675                 680                 685             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    690                 695                 700                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
705                 710                 715                 720 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
                725                 730                 735     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            740                 745                 750         


Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
        755                 760                 765             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    770                 775                 780                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
785                 790                 795                 800 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                805                 810                 815     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu 
            820                 825                 830         


Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu 
        835                 840                 845             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    850                 855                 860                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
865                 870                 875                 880 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                885                 890                 895     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            900                 905                 910         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        915                 920                 925             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    930                 935                 940                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
945                 950                 955                 960 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                965                 970                 975     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985     


<210>  2
<211>  3027
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg       60

cgctgtcagg tgcagctcgt ggaatccggt ggcggcttgg tgaaacctgg cgagtcactg      120

agattgtcat gcgctgcatc aggttttaca ttcagtgatt actatatgta ctgggtacgg      180

caggcacctg gaaaatgcct tgagtgggtc gctattatca gtgacggcgg gtattatacc      240

tattactccg atatcattaa aggaaggttt accatcagcc gagataacgc caaaaactcc      300

ctttaccttc agatgaacag tcttaaagct gaggacactg ctgtttacta ttgtgctaga      360

gggttccccc tgctgcgtca cggcgcaatg gattactggg gccagggcac ccttgtaacc      420

gtaagcagtg gtgggggggg tagtggtggt ggtggctctg gcggtggagg atcagacatc      480

cagatgaccc aaagcccctc tagtctcagc gcaagtgtag gcgaccgggt aaccattaca      540

tgtaaggcat cacagaatgt ggacacaaat gttgcttggt atcagcagaa gccaggacag      600

gctcctaagt cacttatcta cagtgcaagt tatgtgtatt gggacgttcc ttcccgcttt      660

tctggttccg ctagtggaac tgacttcact ttgactattt catcagttca gtctgaggac      720

ttcgccacat attactgcca acaatatgat cagcagctca ttacctttgg ctgtggcaca      780

aagctggaaa tcaagtccgg aggtggtgga tccgaggtgc agctggtcga gtctggagga      840

ggattggtgc agcctggagg gtcattgaaa ctctcatgtg cagcctctgg attcaccttc      900

aataagtacg ccatgaactg ggtccgccag gctccaggaa agggtttgga atgggttgct      960

cgcatcagaa gtaaatataa taattatgca acatattatg ccgattcagt gaaagacagg     1020

ttcaccatct ccagagatga ttcaaaaaac actgcctatc tacaaatgaa caacttgaag     1080

actgaggaca ctgccgtgta ctactgtgtg agacatggga acttcggtaa tagctacatc     1140

tcctactggg cttactgggg ccaagggact ctggtcaccg tgtcctcagg tggtggtggt     1200

tctggcggcg gcggctccgg tggtggtggt tctcagactg ttgtgactca ggaaccttca     1260

ctcaccgtat cacctggtgg aacagtcaca ctcacttgtg gctcctcgac tggggctgtt     1320

acatctggca actacccaaa ctgggtccaa caaaaaccag gtcaggcacc ccgtggtcta     1380

atcggtggga ctaagttcct cgcccccggt actcctgcca gattctcagg ctccctgctt     1440

ggaggcaagg ctgccctcac cctctcaggg gtacagccag aggatgaggc ggaatattac     1500

tgtgttctat ggtacagcaa ccgctgggtg ttcggtggag gaaccaaact gactgtccta     1560

ggcggtggtg gagacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     1620

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     1680

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1740

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgtgcga ggagcagtac     1800

ggcagcacgt accgttgcgt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1860

aaggagtaca agtgcaaggt gtccaacaaa gccctcccag cccccatcga gaaaaccatc     1920

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1980

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     2040

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     2100

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     2160

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     2220

acgcagaaga gcctctccct gtctccgggt aaaggtggag gaggtagcgg aggaggcggc     2280

tccggagggg gcggatctgg cggcggagga agcggtgggg gcggctccgg agggggcggc     2340

tctgacaaga cccacacatg tcctccgtgc cccgcacccg agctgttggg aggaccctcg     2400

gtgtttttgt ttcctcccaa gccaaaggac acgttgatga tttcgcgcac tccagaggtc     2460

acgtgtgtag tcgtggacgt gtcacatgag gaccccgagg taaagttcaa ttggtatgtg     2520

gacggagtcg aggtccataa cgccaaaaca aagccgtgcg aagaacagta cgggtcaacg     2580

tataggtgcg tcagcgtcct cactgtgctg caccaagact ggctcaatgg taaagaatac     2640

aagtgcaagg tgtcgaacaa ggccctccct gcccctatcg agaaaaccat ctccaaagcg     2700

aaggggcagc cgcgagaacc ccaagtctac acgctgccgc cctcgcggga ggaaatgacc     2760

aaaaaccagg tgtcgcttac gtgtcttgtg aaagggttct atccatcaga tatcgcggtc     2820

gagtgggagt cgaacggcca gcccgaaaac aattacaaaa caacacctcc ggtcctcgat     2880

tcagatggaa gcttcttctt gtattcgaag ctgaccgtcg ataagtcaag gtggcaacag     2940

ggaaatgtgt tctcgtgctc agtgatgcac gaggctctgc ataaccacta tacgcagaaa     3000

tcattgtcgc tcagccccgg taaatag                                         3027


<210>  3
<211>  2961
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
caggtgcagc tcgtggaatc cggtggcggc ttggtgaaac ctggcgagtc actgagattg       60

tcatgcgctg catcaggttt tacattcagt gattactata tgtactgggt acggcaggca      120

cctggaaaat gccttgagtg ggtcgctatt atcagtgacg gcgggtatta tacctattac      180

tccgatatca ttaaaggaag gtttaccatc agccgagata acgccaaaaa ctccctttac      240

cttcagatga acagtcttaa agctgaggac actgctgttt actattgtgc tagagggttc      300

cccctgctgc gtcacggcgc aatggattac tggggccagg gcacccttgt aaccgtaagc      360

agtggtgggg ggggtagtgg tggtggtggc tctggcggtg gaggatcaga catccagatg      420

acccaaagcc cctctagtct cagcgcaagt gtaggcgacc gggtaaccat tacatgtaag      480

gcatcacaga atgtggacac aaatgttgct tggtatcagc agaagccagg acaggctcct      540

aagtcactta tctacagtgc aagttatgtg tattgggacg ttccttcccg cttttctggt      600

tccgctagtg gaactgactt cactttgact atttcatcag ttcagtctga ggacttcgcc      660

acatattact gccaacaata tgatcagcag ctcattacct ttggctgtgg cacaaagctg      720

gaaatcaagt ccggaggtgg tggatccgag gtgcagctgg tcgagtctgg aggaggattg      780

gtgcagcctg gagggtcatt gaaactctca tgtgcagcct ctggattcac cttcaataag      840

tacgccatga actgggtccg ccaggctcca ggaaagggtt tggaatgggt tgctcgcatc      900

agaagtaaat ataataatta tgcaacatat tatgccgatt cagtgaaaga caggttcacc      960

atctccagag atgattcaaa aaacactgcc tatctacaaa tgaacaactt gaagactgag     1020

gacactgccg tgtactactg tgtgagacat gggaacttcg gtaatagcta catctcctac     1080

tgggcttact ggggccaagg gactctggtc accgtgtcct caggtggtgg tggttctggc     1140

ggcggcggct ccggtggtgg tggttctcag actgttgtga ctcaggaacc ttcactcacc     1200

gtatcacctg gtggaacagt cacactcact tgtggctcct cgactggggc tgttacatct     1260

ggcaactacc caaactgggt ccaacaaaaa ccaggtcagg caccccgtgg tctaatcggt     1320

gggactaagt tcctcgcccc cggtactcct gccagattct caggctccct gcttggaggc     1380

aaggctgccc tcaccctctc aggggtacag ccagaggatg aggcggaata ttactgtgtt     1440

ctatggtaca gcaaccgctg ggtgttcggt ggaggaacca aactgactgt cctaggcggt     1500

ggtggagaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg     1560

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag     1620

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac     1680

gtggacggcg tggaggtgca taatgccaag acaaagccgt gcgaggagca gtacggcagc     1740

acgtaccgtt gcgtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     1800

tacaagtgca aggtgtccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1860

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1920

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1980

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     2040

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag     2100

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     2160

aagagcctct ccctgtctcc gggtaaaggt ggaggaggta gcggaggagg cggctccgga     2220

gggggcggat ctggcggcgg aggaagcggt gggggcggct ccggaggggg cggctctgac     2280

aagacccaca catgtcctcc gtgccccgca cccgagctgt tgggaggacc ctcggtgttt     2340

ttgtttcctc ccaagccaaa ggacacgttg atgatttcgc gcactccaga ggtcacgtgt     2400

gtagtcgtgg acgtgtcaca tgaggacccc gaggtaaagt tcaattggta tgtggacgga     2460

gtcgaggtcc ataacgccaa aacaaagccg tgcgaagaac agtacgggtc aacgtatagg     2520

tgcgtcagcg tcctcactgt gctgcaccaa gactggctca atggtaaaga atacaagtgc     2580

aaggtgtcga acaaggccct ccctgcccct atcgagaaaa ccatctccaa agcgaagggg     2640

cagccgcgag aaccccaagt ctacacgctg ccgccctcgc gggaggaaat gaccaaaaac     2700

caggtgtcgc ttacgtgtct tgtgaaaggg ttctatccat cagatatcgc ggtcgagtgg     2760

gagtcgaacg gccagcccga aaacaattac aaaacaacac ctccggtcct cgattcagat     2820

ggaagcttct tcttgtattc gaagctgacc gtcgataagt caaggtggca acagggaaat     2880

gtgttctcgt gctcagtgat gcacgaggct ctgcataacc actatacgca gaaatcattg     2940

tcgctcagcc ccggtaaata g                                               2961


<210>  4
<211>  3027
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
atggatatgc gcgtgcccgc tcagctgctg gggctgcttc tgctctggct tcgcggggcc       60

cgctgtcagg tgcaactggt ggaaagcggt ggcggccttg tgaagcctgg ggaatccctc      120

aggctctcct gtgctgctag tggcttcacg ttcagcgact actacatgta ttgggtgcgg      180

caggctccag gaaagtgcct tgagtgggtc gccatcattt ccgatggcgg gtattacacc      240

tactacagcg acatcatcaa gggtcggttt accattagcc gcgacaatgc caagaacagc      300

ctgtatctgc agatgaacag tctgaaagcc gaggatactg ccgtttatta ctgtgcaaga      360

gggtttccct tgttgcgtca cggcgcaatg gactactggg gtcaaggaac actggtgaca      420

gtatcatcag gaggtggagg gtctggcggc ggaggtagtg gaggaggtgg gtccgatatt      480

cagatgactc agtctccttc ctctctgagc gcttctgtag gcgatcgagt caccataacc      540

tgcaaagcaa gccagaatgt ggacacaaac gtggcatggt accaacagaa gccaggccaa      600

gctcccaagt ctctgatcta ttctgcctca tacgtctatt gggatgttcc cagtcggttt      660

agtggatctg cctctgggac agacttcact ctgactatct cctccgttca atccgaggac      720

tttgccacct actattgcca gcagtatgat cagcagctca tcacattcgg ctgtgggacc      780

aaactggaga ttaaatccgg aggtggaggg agcgaagtgc agctcgttga gagcggcgga      840

ggccttgtgc agcctggagg atccctgaag ctgagctgtg ccgcatctgg gttcacattc      900

aacaagtatg ccatgaattg ggtgcgtcag gctcctggta aaggcttgga gtgggtagcc      960

cggattagga gcaaatataa taactatgcc acctactatg ctgactctgt caaggaccgc     1020

tttacaatct ctcgggatga ctccaagaat actgcctacc tccagatgaa caacctcaag     1080

acggaggata ccgccgtcta ctattgcgtc cgacatggca actttgggaa ctcctacatc     1140

tcctattggg cttattgggg ccaggggact cttgtcacag tctcatccgg cggtgggggc     1200

tctggtggag gtgggtcagg aggtggtggg agccaaaccg ttgtaacaca ggagccctcc     1260

ttgactgtgt cacctggcgg aacggtgacg ctgacttgtg gctcatcaac tggagccgta     1320

acatctggaa attaccctaa ctgggtgcag cagaagcctg gtcaggcacc cagaggactg     1380

ataggcggaa ccaaatttct cgctccaggt actccagccc ggttttccgg gtccttgctg     1440

ggcggtaagg ctgccctgac actgagcgga gttcagccag aggatgaagc agaatactat     1500

tgcgtgctgt ggtactccaa caggtgggta tttggaggcg gcaccaagct cacggtcctc     1560

ggcggaggtg gagacaaaac acacacttgt cctccctgtc ctgcacccga acttctggga     1620

ggcccctctg tgttcctttt cccacccaag cccaaagata ccttgatgat cagccgtacg     1680

ccagaggtta catgcgtggt cgttgacgtg tctcatgaag atcccgaagt caagttcaac     1740

tggtacgtgg atggggtgga ggtacataat gcaaagacca agccctgtga ggagcagtat     1800

gggtcaacct atcggtgtgt gtctgtgctg accgtgctgc atcaagattg gttgaatggg     1860

aaggaatata agtgcaaggt gtcaaataag gctctgcccg cacccattga aaagaccata     1920

agtaaggcca aggggcagcc tagggaaccc caggtataca ctctgcctcc atcccgtgag     1980

gagatgacaa agaatcaagt gagcctcacc tgtctggtta aaggcttcta ccccagtgat     2040

atcgctgtgg agtgggagtc aaacgggcag cccgaaaaca actacaaaac cacacctcca     2100

gtcttggata gcgacggatc cttctttctg tactctaaac tcaccgtgga caaaagtaga     2160

tggcagcaag gcaacgtttt cagttgctct gtgatgcacg aagctctcca taatcattat     2220

actcagaaga gcctgtccct ttctcctgga aaaggggggg gtggctccgg cggtggcggc     2280

agtggaggcg gaggctctgg tggtggcggt tccggtggcg ggggaagcgg cggcggtggg     2340

agtgacaaga cacatacctg tcctccatgc ccagctcccg aactgttggg cggacccagc     2400

gtgtttctgt ttccaccaaa gcctaaagac accctgatga tttcaaggac tcctgaggtg     2460

acatgcgtgg tagtggatgt cagccacgag gaccccgaag tgaaattcaa ttggtatgta     2520

gacggggtgg aggtccacaa tgccaagact aaaccctgcg aggagcagta cgggtccact     2580

taccgatgcg ttagtgttct cacagtcctt caccaggact ggctgaacgg aaaggagtac     2640

aaatgcaaag tgtccaacaa agccctgcca gccccaatcg agaaaacaat cagcaaggcc     2700

aagggtcaac ctcgagaacc ccaagtgtat actctgccac cctctcgcga agagatgacc     2760

aagaatcagg tttccctcac ctgtttggtc aaaggctttt acccctctga cattgctgtt     2820

gaatgggaga gtaacggcca gcctgagaac aactataaaa ccaccccacc agtgcttgat     2880

agtgatggct ccttcttcct gtacagcaag ctgacagtgg acaaatctcg ctggcaacag     2940

ggcaatgtct ttagttgctc cgtcatgcac gaggcactgc acaatcacta cactcagaag     3000

tcactgagtc tgagccctgg gaagtag                                         3027


<210>  5
<211>  2961
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
caggtgcaac tggtggaaag cggtggcggc cttgtgaagc ctggggaatc cctcaggctc       60

tcctgtgctg ctagtggctt cacgttcagc gactactaca tgtattgggt gcggcaggct      120

ccaggaaagt gccttgagtg ggtcgccatc atttccgatg gcgggtatta cacctactac      180

agcgacatca tcaagggtcg gtttaccatt agccgcgaca atgccaagaa cagcctgtat      240

ctgcagatga acagtctgaa agccgaggat actgccgttt attactgtgc aagagggttt      300

cccttgttgc gtcacggcgc aatggactac tggggtcaag gaacactggt gacagtatca      360

tcaggaggtg gagggtctgg cggcggaggt agtggaggag gtgggtccga tattcagatg      420

actcagtctc cttcctctct gagcgcttct gtaggcgatc gagtcaccat aacctgcaaa      480

gcaagccaga atgtggacac aaacgtggca tggtaccaac agaagccagg ccaagctccc      540

aagtctctga tctattctgc ctcatacgtc tattgggatg ttcccagtcg gtttagtgga      600

tctgcctctg ggacagactt cactctgact atctcctccg ttcaatccga ggactttgcc      660

acctactatt gccagcagta tgatcagcag ctcatcacat tcggctgtgg gaccaaactg      720

gagattaaat ccggaggtgg agggagcgaa gtgcagctcg ttgagagcgg cggaggcctt      780

gtgcagcctg gaggatccct gaagctgagc tgtgccgcat ctgggttcac attcaacaag      840

tatgccatga attgggtgcg tcaggctcct ggtaaaggct tggagtgggt agcccggatt      900

aggagcaaat ataataacta tgccacctac tatgctgact ctgtcaagga ccgctttaca      960

atctctcggg atgactccaa gaatactgcc tacctccaga tgaacaacct caagacggag     1020

gataccgccg tctactattg cgtccgacat ggcaactttg ggaactccta catctcctat     1080

tgggcttatt ggggccaggg gactcttgtc acagtctcat ccggcggtgg gggctctggt     1140

ggaggtgggt caggaggtgg tgggagccaa accgttgtaa cacaggagcc ctccttgact     1200

gtgtcacctg gcggaacggt gacgctgact tgtggctcat caactggagc cgtaacatct     1260

ggaaattacc ctaactgggt gcagcagaag cctggtcagg cacccagagg actgataggc     1320

ggaaccaaat ttctcgctcc aggtactcca gcccggtttt ccgggtcctt gctgggcggt     1380

aaggctgccc tgacactgag cggagttcag ccagaggatg aagcagaata ctattgcgtg     1440

ctgtggtact ccaacaggtg ggtatttgga ggcggcacca agctcacggt cctcggcgga     1500

ggtggagaca aaacacacac ttgtcctccc tgtcctgcac ccgaacttct gggaggcccc     1560

tctgtgttcc ttttcccacc caagcccaaa gataccttga tgatcagccg tacgccagag     1620

gttacatgcg tggtcgttga cgtgtctcat gaagatcccg aagtcaagtt caactggtac     1680

gtggatgggg tggaggtaca taatgcaaag accaagccct gtgaggagca gtatgggtca     1740

acctatcggt gtgtgtctgt gctgaccgtg ctgcatcaag attggttgaa tgggaaggaa     1800

tataagtgca aggtgtcaaa taaggctctg cccgcaccca ttgaaaagac cataagtaag     1860

gccaaggggc agcctaggga accccaggta tacactctgc ctccatcccg tgaggagatg     1920

acaaagaatc aagtgagcct cacctgtctg gttaaaggct tctaccccag tgatatcgct     1980

gtggagtggg agtcaaacgg gcagcccgaa aacaactaca aaaccacacc tccagtcttg     2040

gatagcgacg gatccttctt tctgtactct aaactcaccg tggacaaaag tagatggcag     2100

caaggcaacg ttttcagttg ctctgtgatg cacgaagctc tccataatca ttatactcag     2160

aagagcctgt ccctttctcc tggaaaaggg gggggtggct ccggcggtgg cggcagtgga     2220

ggcggaggct ctggtggtgg cggttccggt ggcgggggaa gcggcggcgg tgggagtgac     2280

aagacacata cctgtcctcc atgcccagct cccgaactgt tgggcggacc cagcgtgttt     2340

ctgtttccac caaagcctaa agacaccctg atgatttcaa ggactcctga ggtgacatgc     2400

gtggtagtgg atgtcagcca cgaggacccc gaagtgaaat tcaattggta tgtagacggg     2460

gtggaggtcc acaatgccaa gactaaaccc tgcgaggagc agtacgggtc cacttaccga     2520

tgcgttagtg ttctcacagt ccttcaccag gactggctga acggaaagga gtacaaatgc     2580

aaagtgtcca acaaagccct gccagcccca atcgagaaaa caatcagcaa ggccaagggt     2640

caacctcgag aaccccaagt gtatactctg ccaccctctc gcgaagagat gaccaagaat     2700

caggtttccc tcacctgttt ggtcaaaggc ttttacccct ctgacattgc tgttgaatgg     2760

gagagtaacg gccagcctga gaacaactat aaaaccaccc caccagtgct tgatagtgat     2820

ggctccttct tcctgtacag caagctgaca gtggacaaat ctcgctggca acagggcaat     2880

gtctttagtt gctccgtcat gcacgaggca ctgcacaatc actacactca gaagtcactg     2940

agtctgagcc ctgggaagta g                                               2961


<210>  6
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  7
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Ala Trp Ala Leu Leu Leu Leu Thr Leu Leu Thr Gln Gly Thr Gly 
1               5                   10                  15      


Ser Trp Ala 
            


<210>  8
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Thr Cys Ser Pro Leu Leu Leu Thr Leu Leu Ile His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala 
            


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Glu Trp Thr Trp Arg Val Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  11
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Asp Ile Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys 
            20          


<210>  12
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Asp Ile Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  13
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Met Asp Met Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  14
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe 
            20          


<210>  15
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Glu 
            20      


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  20
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
atggatatgc gcgtgcccgc tcagctgctg gggctgcttc tgctctggct tcgcggggcc       60

cgctgt                                                                  66


<210>  21
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
atggcctggg ctctgctgct cctcaccctc ctcactcagg ggacagggtc ctgggcc          57


<210>  22
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
atggcctggg ctctgctgct cctcaccctc ctcactcagg ggaccgggtc ctgggcc          57


<210>  23
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gln Gln Leu Ile 
1               5                   10                  15      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        35                  40                  45              


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
    50                  55                  60                  


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
65                  70                  75                  80  


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
                85                  90                  95      


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
            100                 105                 110         


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
        115                 120                 125             


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
    130                 135                 140                 


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
                165                 170                 175     


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
            180                 185                 190         


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
        195                 200                 205             


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
    210                 215                 220                 


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
225                 230                 235                 240 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
                245                 250                 255     


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
            260                 265                 270         


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
        275                 280                 285             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    290                 295                 300                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
305                 310                 315                 320 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                325                 330                 335     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            340                 345                 350         


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
        355                 360                 365             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
385                 390                 395                 400 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                405                 410                 415     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            420                 425                 430         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        435                 440                 445             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    450                 455                 460                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
465                 470                 475                 480 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                485                 490                 495     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 505                 510         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    530                 535                 540                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
545                 550                 555                 560 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                565                 570                 575     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            580                 585                 590         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        595                 600                 605             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    610                 615                 620                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
625                 630                 635                 640 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                645                 650                 655     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            660                 665                 670         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        675                 680                 685             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    690                 695                 700                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
705                 710                 715                 720 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                725                 730                 735     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            740                 745                 750         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        755                 760                 765             


Gly 
    


