                         SEQUENCE LISTING

<110>  Academia Sinica
       Fu-Tong Liu
       
<120>  ANGIOTENSIN-CONVERTING ENZYME II (ACE2) TRANSGENIC ANIMAL AND 
       USES THEREOF

<130>  ACA0145WO

<150>  63/180,861
<151>  2021-04-28

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  2
<211>  2415
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagaccaaag catcaaagtg     1860

aggataagcc taaaatcagc tcttggagat aaagcatatg aatggaacga caatgaaatg     1920

tacctgttcc gatcatctgt tgcatatgct atgaggcagt actttttaaa agtaaaaaat     1980

cagatgattc tttttgggga ggaggatgtg cgagtggcta atttgaaacc aagaatctcc     2040

tttaatttct ttgtcactgc acctaaaaat gtgtctgata tcattcctag aactgaagtt     2100

gaaaaggcca tcaggatgtc ccggagccgt atcaatgatg ctttccgtct gaatgacaac     2160

agcctagagt ttctggggat acagccaaca cttggacctc ctaaccagcc ccctgtttcc     2220

atatggctga ttgtttttgg agttgtgatg ggagtgatag tggttggcat tgtcatcctg     2280

atcttcactg ggatcagaga tcggaagaag aaaaataaag caagaagtgg agaaaatcct     2340

tatgcctcca tcgatattag caaaggagaa aataatccag gattccaaaa cactgatgat     2400

gttcagacct ccttt                                                      2415


<210>  3
<211>  1674
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG promoter

<400>  3
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc      540

ggggcgaggc ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct      600

tttatggcga ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga      660

gtcgctgcgc gctgccttcg ccccgtgccc cgctccgccg ccgcctcgcg ccgcccgccc      720

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg      780

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc      840

cttggagggg ctccgggagg gccctttgtg cgggggggag cggctcgggg gtgcgtgcgt      900

gtgtgtgtgc gtggggagcg ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg      960

cgggcgcggc gcggggcttt gtgcgctccg cgtgtgcgcg aggggagcgc ggccgggggc     1020

ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1080

tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc     1140

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtac ggggcgtggc     1200

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg     1260

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gcccccggag cgccggcggc     1320

tgtcgaggcg cggcgagccg cagccattgc cttttatggt aatcgtgcga gagggcgcag     1380

ggacttcctt tgtcccaaat ctgtgcggag ccgaaatctg ggaggcgccg ccgcaccccc     1440

tctagcgggc gcggggcgaa gcggtgcggc gccggcagga aggaaatggg cggggagggc     1500

cttcgtgcgt cgccgcgccg ccgtcccctt ctccctctcc agcctcgggg ctgtccgcgg     1560

ggggacggct gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc     1620

ggcggctcta gagcctctgc taaccatgtt catgccttct tctttttcct acag           1674


<210>  4
<211>  966
<212>  DNA
<213>  Gallus gallus

<400>  4
gccccatcct cactgactcc gtcctggagt tggatgagag ataatggcct tacgttgtgc       60

caggggaggg tcgggctgga tttagcaaga tttaccttct ccaaagagcg gtgctgcagt      120

ggcacagctg cccacggagg tgggggggtc accgtccctg gaggtgatga agaactgtgg      180

ggatgtggca ctgagggaca tggccagtgg gcacggtggg tgggttgggg ttggtcttgg      240

ggatcttgga gggcttttcc agccttcatg atttgacgat tgtatgaaca tctacatggc      300

aattctccag ctgcctgtcc cagtcctact gacccagctg tatctctcca ggcaagctct      360

tccacccctt ctgcttgcat ccagacacca tcaaacatgc aggctcagac acagggacca      420

gcagtgtctg tggccttttt gtgctcctct ccatgctggg ttttaacttg ctctttgtcc      480

ttctatccta tcttcttatc cttaaggctg ttctgaacgc tgtgacttgg agagtgtccc      540

agagccctca acacctgcat gtcccacgtc catgctgtcc tgcacttcct tatccccaag      600

atctgcctct ccgtgatgca ctgaattggc aaacatgtgt caccccagac caacaatgtc      660

acagcaaact cccccttgat aggacaaggg ggaatggctt tacactgaga caggggaggt      720

ttgggttgga tatgaggagg cagtttttcc cccagagggt ggtgacgcac tgaacaggtt      780

gcccaaggag gctgtggatg ccccatccct gcaggcattc aaggccaggc tggatgtggc      840

tctgggcagc ctgggctgct ggttgatgac cctgcacata gcagggggtt ggatctggat      900

gagcactgtg ctcctttgca acccaggccg ttctatgatt ctgtcattct aaatctctct      960

ttcagc                                                                 966


<210>  5
<211>  9
<212>  PRT
<213>  Influenza A virus

<400>  5

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  6
<211>  27
<212>  DNA
<213>  Influenza A virus

<400>  6
tacccatacg atgttccaga ttacgct                                           27


<210>  7
<211>  9433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hACE2 expression cassette (w/o NotI)

<400>  7
tgggtacccg gggatctgct cgagcagatc ctctagagcc ccatcctcac tgactccgtc       60

ctggagttgg atgagagata atggccttac gttgtgccag gggagggtcg ggctggattt      120

agcaagattt accttctcca aagagcggtg ctgcagtggc acagctgccc acggaggtgg      180

gggggtcacc gtccctggag gtgatgaaga actgtgggga tgtggcactg agggacatgg      240

ccagtgggca cggtgggtgg gttggggttg gtcttgggga tcttggaggg cttttccagc      300

cttcatgatt tgacgattgt atgaacatct acatggcaat tctccagctg cctgtcccag      360

tcctactgac ccagctgtat ctctccaggc aagctcttcc accccttctg cttgcatcca      420

gacaccatca aacatgcagg ctcagacaca gggaccagca gtgtctgtgg cctttttgtg      480

ctcctctcca tgctgggttt taacttgctc tttgtccttc tatcctatct tcttatcctt      540

aaggctgttc tgaacgctgt gacttggaga gtgtcccaga gccctcaaca cctgcatgtc      600

ccacgtccat gctgtcctgc acttccttat ccccaagatc tgcctctccg tgatgcactg      660

aattggcaaa catgtgtcac cccagaccaa caatgtcaca gcaaactccc ccttgatagg      720

acaaggggga atggctttac actgagacag gggaggtttg ggttggatat gaggaggcag      780

tttttccccc agagggtggt gacgcactga acaggttgcc caaggaggct gtggatgccc      840

catccctgca ggcattcaag gccaggctgg atgtggctct gggcagcctg ggctgctggt      900

tgatgaccct gcacatagca gggggttgga tctggatgag cactgtgctc ctttgcaacc      960

caggccgttc tatgattctg tcattctaaa tctctctttc agcctaaagc tttttccccg     1020

tatcccccca ggtgtctgca ggctcaaaga gcagcgagaa gcgttcagag gaaagcgatc     1080

ccgtgccacc ttccccgtgc ccgggctgtc cccgcacgct gccggctcgg ggatgcgggg     1140

ggagcgccgg accggagcgg agccccgggc ggctcgctgc tgccccctag cgggggaggg     1200

acgtaattac atccctgggg gctttggggg ggggctgtcc ctctagagcc ccatcctcac     1260

tgactccgtc ctggagttgg atgagagata atggccttac gttgtgccag gggagggtcg     1320

ggctggattt agcaagattt accttctcca aagagcggtg ctgcagtggc acagctgccc     1380

acggaggtgg gggggtcacc gtccctggag gtgatgaaga actgtgggga tgtggcactg     1440

agggacatgg ccagtgggca cggtgggtgg gttggggttg gtcttgggga tcttggaggg     1500

cttttccagc cttcatgatt tgacgattgt atgaacatct acatggcaat tctccagctg     1560

cctgtcccag tcctactgac ccagctgtat ctctccaggc aagctcttcc accccttctg     1620

cttgcatcca gacaccatca aacatgcagg ctcagacaca gggaccagca gtgtctgtgg     1680

cctttttgtg ctcctctcca tgctgggttt taacttgctc tttgtccttc tatcctatct     1740

tcttatcctt aaggctgttc tgaacgctgt gacttggaga gtgtcccaga gccctcaaca     1800

cctgcatgtc ccacgtccat gctgtcctgc acttccttat ccccaagatc tgcctctccg     1860

tgatgcactg aattggcaaa catgtgtcac cccagaccaa caatgtcaca gcaaactccc     1920

ccttgatagg acaaggggga atggctttac actgagacag gggaggtttg ggttggatat     1980

gaggaggcag tttttccccc agagggtggt gacgcactga acaggttgcc caaggaggct     2040

gtggatgccc catccctgca ggcattcaag gccaggctgg atgtggctct gggcagcctg     2100

ggctgctggt tgatgaccct gcacatagca gggggttgga tctggatgag cactgtgctc     2160

ctttgcaacc caggccgttc tatgattctg tcattctaaa tctctctttc agcctaaagc     2220

tttttccccg tatcccccca ggtgtctgca ggctcaaaga gcagcgagaa gcgttcagag     2280

gaaagcgatc ccgtgccacc ttccccgtgc ccgggctgtc cccgcacgct gccggctcgg     2340

ggatgcgggg ggagcgccgg accggagcgg agccccgggc ggctcgctgc tgccccctag     2400

cgggggaggg acgtaattac atccctgggg gctttggggg ggggctgtcc ctctagagtc     2460

gaggtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc     2520

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac     2580

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa     2640

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag     2700

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc     2760

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct     2820

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc     2880

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg     2940

cagcgatggg ggcggggggg gggggggcgc gcgccaggcg gggcggggcg gggcgagggg     3000

cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc gctccgaaag     3060

tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg     3120

gcgggagtcg ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc ctcgcgccgc     3180

ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga cggcccttct     3240

cctccgggct gtaattagcg cttggtttaa tgacggcttg tttcttttct gtggctgcgt     3300

gaaagccttg gaggggctcc gggagggccc tttgtgcggg ggggagcggc tcgggggtgc     3360

gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc gcgctgcccg gcggctgtga     3420

gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcgtg tgcgcgaggg gagcgcggcc     3480

gggggcggtg ccccgcggtg cgggggggct gcgaggggaa caaaggctgc gtgcggggtg     3540

tgtgcgtggg ggggtgagca gggggtgtgg gcgcggcggt cgggctgtaa cccccccctg     3600

cacccccctc cccgagttgc tgagcacggc ccggcttcgg gtgcggggct ccgtacgggg     3660

cgtggcgcgg ggctcgccgt gccgggcggg gggtggcggc aggtgggggt gccgggcggg     3720

gcggggccgc ctcgggccgg ggagggctcg ggggaggggc gcggcggccc ccggagcgcc     3780

ggcggctgtc gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg     3840

gcgcagggac ttcctttgtc ccaaatctgt gcggagccga aatctgggag gcgccgccgc     3900

accccctcta gcgggcgcgg ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg     3960

gagggccttc gtgcgtcgcc gcgccgccgt ccccttctcc ctctccagcc tcggggctgt     4020

ccgcgggggg acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt     4080

gtgaccggcg gctctagagc ctctgctaac catgttcatg ccttcttctt tttcctacag     4140

ctcctgggca acgtgctggt tattgtgctg tctcatcatt ttggcaaaga attgccctct     4200

aggccaccat gtcaagctct tcctggctcc ttctcagcct tgttgctgta actgctgctc     4260

agtccaccat tgaggaacag gccaagacat ttttggacaa gtttaaccac gaagccgaag     4320

acctgttcta tcaaagttca cttgcttctt ggaattataa caccaatatt actgaagaga     4380

atgtccaaaa catgaataat gctggggaca aatggtctgc ctttttaaag gaacagtcca     4440

cacttgccca aatgtatcca ctacaagaaa ttcagaatct cacagtcaag cttcagctgc     4500

aggctcttca gcaaaatggg tcttcagtgc tctcagaaga caagagcaaa cggttgaaca     4560

caattctaaa tacaatgagc accatctaca gtactggaaa agtttgtaac ccagataatc     4620

cacaagaatg cttattactt gaaccaggtt tgaatgaaat aatggcaaac agtttagact     4680

acaatgagag gctctgggct tgggaaagct ggagatctga ggtcggcaag cagctgaggc     4740

cattatatga agagtatgtg gtcttgaaaa atgagatggc aagagcaaat cattatgagg     4800

actatgggga ttattggaga ggagactatg aagtaaatgg ggtagatggc tatgactaca     4860

gccgcggcca gttgattgaa gatgtggaac atacctttga agagattaaa ccattatatg     4920

aacatcttca tgcctatgtg agggcaaagt tgatgaatgc ctatccttcc tatatcagtc     4980

caattggatg cctccctgct catttgcttg gtgatatgtg gggtagattt tggacaaatc     5040

tgtactcttt gacagttccc tttggacaga aaccaaacat agatgttact gatgcaatgg     5100

tggaccaggc ctgggatgca cagagaatat tcaaggaggc cgagaagttc tttgtatctg     5160

ttggtcttcc taatatgact caaggattct gggaaaattc catgctaacg gacccaggaa     5220

atgttcagaa agcagtctgc catcccacag cttgggacct ggggaagggc gacttcagga     5280

tccttatgtg cacaaaggtg acaatggacg acttcctgac agctcatcat gagatggggc     5340

atatccagta tgatatggca tatgctgcac aaccttttct gctaagaaat ggagctaatg     5400

aaggattcca tgaagctgtt ggggaaatca tgtcactttc tgcagccaca cctaagcatt     5460

taaaatccat tggtcttctg tcacccgatt ttcaagaaga caatgaaaca gaaataaact     5520

tcctgctcaa acaagcactc acgattgttg ggactctgcc atttacttac atgttagaga     5580

agtggaggtg gatggtcttt aaaggggaaa ttcccaaaga ccagtggatg aaaaagtggt     5640

gggagatgaa gcgagagata gttggggtgg tggaacctgt gccccatgat gaaacatact     5700

gtgaccccgc atctctgttc catgtttcta atgattactc attcattcga tattacacaa     5760

ggacccttta ccaattccag tttcaagaag cactttgtca agcagctaaa catgaaggcc     5820

ctctgcacaa atgtgacatc tcaaactcta cagaagctgg acagaaactg ttcaatatgc     5880

tgaggcttgg aaaatcagaa ccctggaccc tagcattgga aaatgttgta ggagcaaaga     5940

acatgaatgt aaggccactg ctcaactact ttgagccctt atttacctgg ctgaaagacc     6000

agaacaagaa ttcttttgtg ggatggagta ccgactggag tccatatgca gaccaaagca     6060

tcaaagtgag gataagccta aaatcagctc ttggagataa agcatatgaa tggaacgaca     6120

atgaaatgta cctgttccga tcatctgttg catatgctat gaggcagtac tttttaaaag     6180

taaaaaatca gatgattctt tttggggagg aggatgtgcg agtggctaat ttgaaaccaa     6240

gaatctcctt taatttcttt gtcactgcac ctaaaaatgt gtctgatatc attcctagaa     6300

ctgaagttga aaaggccatc aggatgtccc ggagccgtat caatgatgct ttccgtctga     6360

atgacaacag cctagagttt ctggggatac agccaacact tggacctcct aaccagcccc     6420

ctgtttccat atggctgatt gtttttggag ttgtgatggg agtgatagtg gttggcattg     6480

tcatcctgat cttcactggg atcagagatc ggaagaagaa aaataaagca agaagtggag     6540

aaaatcctta tgcctccatc gatattagca aaggagaaaa taatccagga ttccaaaaca     6600

ctgatgatgt tcagacctcc tttggtaccg agacctccca ggtggcgccc gctggatacc     6660

catacgatgt tccagattac gcttaagctt ggatccgcgt taagtttaaa ccgctgatca     6720

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     6780

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     6840

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     6900

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     6960

gcggaaagaa ccagctggaa ttcctgcagc ccgggggatc cactagttct agagccccat     7020

cctcactgac tccgtcctgg agttggatga gagataatgg ccttacgttg tgccagggga     7080

gggtcgggct ggatttagca agatttacct tctccaaaga gcggtgctgc agtggcacag     7140

ctgcccacgg aggtgggggg gtcaccgtcc ctggaggtga tgaagaactg tggggatgtg     7200

gcactgaggg acatggccag tgggcacggt gggtgggttg gggttggtct tggggatctt     7260

ggagggcttt tccagccttc atgatttgac gattgtatga acatctacat ggcaattctc     7320

cagctgcctg tcccagtcct actgacccag ctgtatctct ccaggcaagc tcttccaccc     7380

cttctgcttg catccagaca ccatcaaaca tgcaggctca gacacaggga ccagcagtgt     7440

ctgtggcctt tttgtgctcc tctccatgct gggttttaac ttgctctttg tccttctatc     7500

ctatcttctt atccttaagg ctgttctgaa cgctgtgact tggagagtgt cccagagccc     7560

tcaacacctg catgtcccac gtccatgctg tcctgcactt ccttatcccc aagatctgcc     7620

tctccgtgat gcactgaatt ggcaaacatg tgtcacccca gaccaacaat gtcacagcaa     7680

actccccctt gataggacaa gggggaatgg ctttacactg agacagggga ggtttgggtt     7740

ggatatgagg aggcagtttt tcccccagag ggtggtgacg cactgaacag gttgcccaag     7800

gaggctgtgg atgccccatc cctgcaggca ttcaaggcca ggctggatgt ggctctgggc     7860

agcctgggct gctggttgat gaccctgcac atagcagggg gttggatctg gatgagcact     7920

gtgctccttt gcaacccagg ccgttctatg attctgtcat tctaaatctc tctttcagcc     7980

taaagctttt tccccgtatc cccccaggtg tctgcaggct caaagagcag cgagaagcgt     8040

tcagaggaaa gcgatcccgt gccaccttcc ccgtgcccgg gctgtccccg cacgctgccg     8100

gctcggggat gcggggggag cgccggaccg gagcggagcc ccgggcggct cgctgctgcc     8160

ccctagcggg ggagggacgt aattacatcc ctgggggctt tggggggggg ctgtccctct     8220

agagccccat cctcactgac tccgtcctgg agttggatga gagataatgg ccttacgttg     8280

tgccagggga gggtcgggct ggatttagca agatttacct tctccaaaga gcggtgctgc     8340

agtggcacag ctgcccacgg aggtgggggg gtcaccgtcc ctggaggtga tgaagaactg     8400

tggggatgtg gcactgaggg acatggccag tgggcacggt gggtgggttg gggttggtct     8460

tggggatctt ggagggcttt tccagccttc atgatttgac gattgtatga acatctacat     8520

ggcaattctc cagctgcctg tcccagtcct actgacccag ctgtatctct ccaggcaagc     8580

tcttccaccc cttctgcttg catccagaca ccatcaaaca tgcaggctca gacacaggga     8640

ccagcagtgt ctgtggcctt tttgtgctcc tctccatgct gggttttaac ttgctctttg     8700

tccttctatc ctatcttctt atccttaagg ctgttctgaa cgctgtgact tggagagtgt     8760

cccagagccc tcaacacctg catgtcccac gtccatgctg tcctgcactt ccttatcccc     8820

aagatctgcc tctccgtgat gcactgaatt ggcaaacatg tgtcacccca gaccaacaat     8880

gtcacagcaa actccccctt gataggacaa gggggaatgg ctttacactg agacagggga     8940

ggtttgggtt ggatatgagg aggcagtttt tcccccagag ggtggtgacg cactgaacag     9000

gttgcccaag gaggctgtgg atgccccatc cctgcaggca ttcaaggcca ggctggatgt     9060

ggctctgggc agcctgggct gctggttgat gaccctgcac atagcagggg gttggatctg     9120

gatgagcact gtgctccttt gcaacccagg ccgttctatg attctgtcat tctaaatctc     9180

tctttcagcc taaagctttt tccccgtatc cccccaggtg tctgcaggct caaagagcag     9240

cgagaagcgt tcagaggaaa gcgatcccgt gccaccttcc ccgtgcccgg gctgtccccg     9300

cacgctgccg gctcggggat gcggggggag cgccggaccg gagcggagcc ccgggcggct     9360

cgctgctgcc ccctagcggg ggagggacgt aattacatcc ctgggggctt tggggggggg     9420

ctgtccctct aga                                                        9433


<210>  8
<211>  9449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hACE2 expression cassette (w/ NotI)

<400>  8
gcggccgctg ggtacccggg gatctgctcg agcagatcct ctagagcccc atcctcactg       60

actccgtcct ggagttggat gagagataat ggccttacgt tgtgccaggg gagggtcggg      120

ctggatttag caagatttac cttctccaaa gagcggtgct gcagtggcac agctgcccac      180

ggaggtgggg gggtcaccgt ccctggaggt gatgaagaac tgtggggatg tggcactgag      240

ggacatggcc agtgggcacg gtgggtgggt tggggttggt cttggggatc ttggagggct      300

tttccagcct tcatgatttg acgattgtat gaacatctac atggcaattc tccagctgcc      360

tgtcccagtc ctactgaccc agctgtatct ctccaggcaa gctcttccac cccttctgct      420

tgcatccaga caccatcaaa catgcaggct cagacacagg gaccagcagt gtctgtggcc      480

tttttgtgct cctctccatg ctgggtttta acttgctctt tgtccttcta tcctatcttc      540

ttatccttaa ggctgttctg aacgctgtga cttggagagt gtcccagagc cctcaacacc      600

tgcatgtccc acgtccatgc tgtcctgcac ttccttatcc ccaagatctg cctctccgtg      660

atgcactgaa ttggcaaaca tgtgtcaccc cagaccaaca atgtcacagc aaactccccc      720

ttgataggac aagggggaat ggctttacac tgagacaggg gaggtttggg ttggatatga      780

ggaggcagtt tttcccccag agggtggtga cgcactgaac aggttgccca aggaggctgt      840

ggatgcccca tccctgcagg cattcaaggc caggctggat gtggctctgg gcagcctggg      900

ctgctggttg atgaccctgc acatagcagg gggttggatc tggatgagca ctgtgctcct      960

ttgcaaccca ggccgttcta tgattctgtc attctaaatc tctctttcag cctaaagctt     1020

tttccccgta tccccccagg tgtctgcagg ctcaaagagc agcgagaagc gttcagagga     1080

aagcgatccc gtgccacctt ccccgtgccc gggctgtccc cgcacgctgc cggctcgggg     1140

atgcgggggg agcgccggac cggagcggag ccccgggcgg ctcgctgctg ccccctagcg     1200

ggggagggac gtaattacat ccctgggggc tttggggggg ggctgtccct ctagagcccc     1260

atcctcactg actccgtcct ggagttggat gagagataat ggccttacgt tgtgccaggg     1320

gagggtcggg ctggatttag caagatttac cttctccaaa gagcggtgct gcagtggcac     1380

agctgcccac ggaggtgggg gggtcaccgt ccctggaggt gatgaagaac tgtggggatg     1440

tggcactgag ggacatggcc agtgggcacg gtgggtgggt tggggttggt cttggggatc     1500

ttggagggct tttccagcct tcatgatttg acgattgtat gaacatctac atggcaattc     1560

tccagctgcc tgtcccagtc ctactgaccc agctgtatct ctccaggcaa gctcttccac     1620

cccttctgct tgcatccaga caccatcaaa catgcaggct cagacacagg gaccagcagt     1680

gtctgtggcc tttttgtgct cctctccatg ctgggtttta acttgctctt tgtccttcta     1740

tcctatcttc ttatccttaa ggctgttctg aacgctgtga cttggagagt gtcccagagc     1800

cctcaacacc tgcatgtccc acgtccatgc tgtcctgcac ttccttatcc ccaagatctg     1860

cctctccgtg atgcactgaa ttggcaaaca tgtgtcaccc cagaccaaca atgtcacagc     1920

aaactccccc ttgataggac aagggggaat ggctttacac tgagacaggg gaggtttggg     1980

ttggatatga ggaggcagtt tttcccccag agggtggtga cgcactgaac aggttgccca     2040

aggaggctgt ggatgcccca tccctgcagg cattcaaggc caggctggat gtggctctgg     2100

gcagcctggg ctgctggttg atgaccctgc acatagcagg gggttggatc tggatgagca     2160

ctgtgctcct ttgcaaccca ggccgttcta tgattctgtc attctaaatc tctctttcag     2220

cctaaagctt tttccccgta tccccccagg tgtctgcagg ctcaaagagc agcgagaagc     2280

gttcagagga aagcgatccc gtgccacctt ccccgtgccc gggctgtccc cgcacgctgc     2340

cggctcgggg atgcgggggg agcgccggac cggagcggag ccccgggcgg ctcgctgctg     2400

ccccctagcg ggggagggac gtaattacat ccctgggggc tttggggggg ggctgtccct     2460

ctagagtcga ggtcgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc     2520

attagttcat agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc     2580

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt     2640

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca     2700

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg     2760

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca     2820

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt     2880

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt     2940

attttgtgca gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg     3000

gcgaggggcg gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc     3060

tccgaaagtt tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg     3120

cgcggcgggc gggagtcgct gcgcgctgcc ttcgccccgt gccccgctcc gccgccgcct     3180

cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg     3240

gcccttctcc tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt     3300

ggctgcgtga aagccttgga ggggctccgg gagggccctt tgtgcggggg ggagcggctc     3360

gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc gctgcccggc     3420

ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcgtgtg cgcgagggga     3480

gcgcggccgg gggcggtgcc ccgcggtgcg ggggggctgc gaggggaaca aaggctgcgt     3540

gcggggtgtg tgcgtggggg ggtgagcagg gggtgtgggc gcggcggtcg ggctgtaacc     3600

cccccctgca cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc     3660

gtacggggcg tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc     3720

cgggcggggc ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc     3780

ggagcgccgg cggctgtcga ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt     3840

gcgagagggc gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc     3900

gccgccgcac cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa     3960

tgggcgggga gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct ctccagcctc     4020

ggggctgtcc gcggggggac ggctgccttc gggggggacg gggcagggcg gggttcggct     4080

tctggcgtgt gaccggcggc tctagagcct ctgctaacca tgttcatgcc ttcttctttt     4140

tcctacagct cctgggcaac gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat     4200

tgccctctag gccaccatgt caagctcttc ctggctcctt ctcagccttg ttgctgtaac     4260

tgctgctcag tccaccattg aggaacaggc caagacattt ttggacaagt ttaaccacga     4320

agccgaagac ctgttctatc aaagttcact tgcttcttgg aattataaca ccaatattac     4380

tgaagagaat gtccaaaaca tgaataatgc tggggacaaa tggtctgcct ttttaaagga     4440

acagtccaca cttgcccaaa tgtatccact acaagaaatt cagaatctca cagtcaagct     4500

tcagctgcag gctcttcagc aaaatgggtc ttcagtgctc tcagaagaca agagcaaacg     4560

gttgaacaca attctaaata caatgagcac catctacagt actggaaaag tttgtaaccc     4620

agataatcca caagaatgct tattacttga accaggtttg aatgaaataa tggcaaacag     4680

tttagactac aatgagaggc tctgggcttg ggaaagctgg agatctgagg tcggcaagca     4740

gctgaggcca ttatatgaag agtatgtggt cttgaaaaat gagatggcaa gagcaaatca     4800

ttatgaggac tatggggatt attggagagg agactatgaa gtaaatgggg tagatggcta     4860

tgactacagc cgcggccagt tgattgaaga tgtggaacat acctttgaag agattaaacc     4920

attatatgaa catcttcatg cctatgtgag ggcaaagttg atgaatgcct atccttccta     4980

tatcagtcca attggatgcc tccctgctca tttgcttggt gatatgtggg gtagattttg     5040

gacaaatctg tactctttga cagttccctt tggacagaaa ccaaacatag atgttactga     5100

tgcaatggtg gaccaggcct gggatgcaca gagaatattc aaggaggccg agaagttctt     5160

tgtatctgtt ggtcttccta atatgactca aggattctgg gaaaattcca tgctaacgga     5220

cccaggaaat gttcagaaag cagtctgcca tcccacagct tgggacctgg ggaagggcga     5280

cttcaggatc cttatgtgca caaaggtgac aatggacgac ttcctgacag ctcatcatga     5340

gatggggcat atccagtatg atatggcata tgctgcacaa ccttttctgc taagaaatgg     5400

agctaatgaa ggattccatg aagctgttgg ggaaatcatg tcactttctg cagccacacc     5460

taagcattta aaatccattg gtcttctgtc acccgatttt caagaagaca atgaaacaga     5520

aataaacttc ctgctcaaac aagcactcac gattgttggg actctgccat ttacttacat     5580

gttagagaag tggaggtgga tggtctttaa aggggaaatt cccaaagacc agtggatgaa     5640

aaagtggtgg gagatgaagc gagagatagt tggggtggtg gaacctgtgc cccatgatga     5700

aacatactgt gaccccgcat ctctgttcca tgtttctaat gattactcat tcattcgata     5760

ttacacaagg accctttacc aattccagtt tcaagaagca ctttgtcaag cagctaaaca     5820

tgaaggccct ctgcacaaat gtgacatctc aaactctaca gaagctggac agaaactgtt     5880

caatatgctg aggcttggaa aatcagaacc ctggacccta gcattggaaa atgttgtagg     5940

agcaaagaac atgaatgtaa ggccactgct caactacttt gagcccttat ttacctggct     6000

gaaagaccag aacaagaatt cttttgtggg atggagtacc gactggagtc catatgcaga     6060

ccaaagcatc aaagtgagga taagcctaaa atcagctctt ggagataaag catatgaatg     6120

gaacgacaat gaaatgtacc tgttccgatc atctgttgca tatgctatga ggcagtactt     6180

tttaaaagta aaaaatcaga tgattctttt tggggaggag gatgtgcgag tggctaattt     6240

gaaaccaaga atctccttta atttctttgt cactgcacct aaaaatgtgt ctgatatcat     6300

tcctagaact gaagttgaaa aggccatcag gatgtcccgg agccgtatca atgatgcttt     6360

ccgtctgaat gacaacagcc tagagtttct ggggatacag ccaacacttg gacctcctaa     6420

ccagccccct gtttccatat ggctgattgt ttttggagtt gtgatgggag tgatagtggt     6480

tggcattgtc atcctgatct tcactgggat cagagatcgg aagaagaaaa ataaagcaag     6540

aagtggagaa aatccttatg cctccatcga tattagcaaa ggagaaaata atccaggatt     6600

ccaaaacact gatgatgttc agacctcctt tggtaccgag acctcccagg tggcgcccgc     6660

tggataccca tacgatgttc cagattacgc ttaagcttgg atccgcgtta agtttaaacc     6720

gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg     6780

tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa     6840

ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca     6900

gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg     6960

cttctgaggc ggaaagaacc agctggaatt cctgcagccc gggggatcca ctagttctag     7020

agccccatcc tcactgactc cgtcctggag ttggatgaga gataatggcc ttacgttgtg     7080

ccaggggagg gtcgggctgg atttagcaag atttaccttc tccaaagagc ggtgctgcag     7140

tggcacagct gcccacggag gtgggggggt caccgtccct ggaggtgatg aagaactgtg     7200

gggatgtggc actgagggac atggccagtg ggcacggtgg gtgggttggg gttggtcttg     7260

gggatcttgg agggcttttc cagccttcat gatttgacga ttgtatgaac atctacatgg     7320

caattctcca gctgcctgtc ccagtcctac tgacccagct gtatctctcc aggcaagctc     7380

ttccacccct tctgcttgca tccagacacc atcaaacatg caggctcaga cacagggacc     7440

agcagtgtct gtggcctttt tgtgctcctc tccatgctgg gttttaactt gctctttgtc     7500

cttctatcct atcttcttat ccttaaggct gttctgaacg ctgtgacttg gagagtgtcc     7560

cagagccctc aacacctgca tgtcccacgt ccatgctgtc ctgcacttcc ttatccccaa     7620

gatctgcctc tccgtgatgc actgaattgg caaacatgtg tcaccccaga ccaacaatgt     7680

cacagcaaac tcccccttga taggacaagg gggaatggct ttacactgag acaggggagg     7740

tttgggttgg atatgaggag gcagtttttc ccccagaggg tggtgacgca ctgaacaggt     7800

tgcccaagga ggctgtggat gccccatccc tgcaggcatt caaggccagg ctggatgtgg     7860

ctctgggcag cctgggctgc tggttgatga ccctgcacat agcagggggt tggatctgga     7920

tgagcactgt gctcctttgc aacccaggcc gttctatgat tctgtcattc taaatctctc     7980

tttcagccta aagctttttc cccgtatccc cccaggtgtc tgcaggctca aagagcagcg     8040

agaagcgttc agaggaaagc gatcccgtgc caccttcccc gtgcccgggc tgtccccgca     8100

cgctgccggc tcggggatgc ggggggagcg ccggaccgga gcggagcccc gggcggctcg     8160

ctgctgcccc ctagcggggg agggacgtaa ttacatccct gggggctttg ggggggggct     8220

gtccctctag agccccatcc tcactgactc cgtcctggag ttggatgaga gataatggcc     8280

ttacgttgtg ccaggggagg gtcgggctgg atttagcaag atttaccttc tccaaagagc     8340

ggtgctgcag tggcacagct gcccacggag gtgggggggt caccgtccct ggaggtgatg     8400

aagaactgtg gggatgtggc actgagggac atggccagtg ggcacggtgg gtgggttggg     8460

gttggtcttg gggatcttgg agggcttttc cagccttcat gatttgacga ttgtatgaac     8520

atctacatgg caattctcca gctgcctgtc ccagtcctac tgacccagct gtatctctcc     8580

aggcaagctc ttccacccct tctgcttgca tccagacacc atcaaacatg caggctcaga     8640

cacagggacc agcagtgtct gtggcctttt tgtgctcctc tccatgctgg gttttaactt     8700

gctctttgtc cttctatcct atcttcttat ccttaaggct gttctgaacg ctgtgacttg     8760

gagagtgtcc cagagccctc aacacctgca tgtcccacgt ccatgctgtc ctgcacttcc     8820

ttatccccaa gatctgcctc tccgtgatgc actgaattgg caaacatgtg tcaccccaga     8880

ccaacaatgt cacagcaaac tcccccttga taggacaagg gggaatggct ttacactgag     8940

acaggggagg tttgggttgg atatgaggag gcagtttttc ccccagaggg tggtgacgca     9000

ctgaacaggt tgcccaagga ggctgtggat gccccatccc tgcaggcatt caaggccagg     9060

ctggatgtgg ctctgggcag cctgggctgc tggttgatga ccctgcacat agcagggggt     9120

tggatctgga tgagcactgt gctcctttgc aacccaggcc gttctatgat tctgtcattc     9180

taaatctctc tttcagccta aagctttttc cccgtatccc cccaggtgtc tgcaggctca     9240

aagagcagcg agaagcgttc agaggaaagc gatcccgtgc caccttcccc gtgcccgggc     9300

tgtccccgca cgctgccggc tcggggatgc ggggggagcg ccggaccgga gcggagcccc     9360

gggcggctcg ctgctgcccc ctagcggggg agggacgtaa ttacatccct gggggctttg     9420

ggggggggct gtccctctag agcggccgc                                       9449


<210>  9
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer F (spike gene)

<400>  9
aacttaagct tggtaccgcc accatgttcg tcttcctggt cctg                        44


<210>  10
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer R (spike gene)

<400>  10
tgctggatat ctgcagaatt cttacttaca gcaggagcca cagctacagc ag               52


<210>  11
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer F (hACE2 gene)

<400>  11
gggagaccca agctggctag ccaccatgtc aagctcttcc tggctccttc                  50


<210>  12
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer R (hACE2 gene)

<400>  12
ttgtctcaag atctagaatt cctaaaagga ggtctgaaca tcatcagtg                   49


<210>  13
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer F (hACE2 cDNA)

<400>  13
gccctctagg ccaccatgtc aagctcttcc tgg                                    33


<210>  14
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer R (hACE2 cDNA)

<400>  14
ctaagcgggc gccacctggg aggtctcggt accaaaggag gtctgaacat catcagtgt        59


<210>  15
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer F (HA)

<400>  15
gttccagatt acgcttaagc ttggatccgc gttaagttta aaccgctg                    48


<210>  16
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer R (HA)

<400>  16
atcgtatggg tatccagcgg gcgccacctg gga                                    33


<210>  17
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer F (ACE2) (genotyping)

<400>  17
gagactatga agtaaatggg gtagatggc                                         29


<210>  18
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer R (ACE2) (genotyping)

<400>  18
cttcattagc tccatttctt agcagaaaag g                                      31


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer F (Tbp)

<400>  19
ttgctactgc ctgctgtt                                                     18


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer R (Tbp)

<400>  20
ggacttactc cacagcctat tc                                                22


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe (Tbp)

<400>  21
ttgctgctgc tgtctttgtt gctc                                              24


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer F (hACE2 transgene)

<400>  22
ctaacggacc caggaaatgt tcaga                                             25


<210>  23
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer R (hACE2 transgene)

<400>  23
ggttgtgcag catatgccat atcatac                                           27


<210>  24
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe (hACE2)

<400>  24
aagggcgact tcaggatcct tatgtgcac                                         29


