
                                SEQUENCE LISTING

<110> Minotaur Therapeutics, Inc.

<120> HUMANIZED CHIMERIC BOVINE ANTIBODIES AND
  METHODS OF USE

<130> 166262000340

<140> Not Yet Assigned     
<141> Concurrently Herewith  

<150> US 63/181,223       
<151> 2021-04-28  

<160> 211

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-15

<400> 1
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile
 1               5                  10                  15      
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His
            20                  25                  30          
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln
        35                  40                  45              
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu
    50                  55                  60                  
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val
65                  70                  75                  80  
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile
                85                  90                  95      
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn
            100                 105                 110         
Thr Ser
        


<210> 2
<211> 77
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL-15-Ralphasushi

<400> 2
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val
 1               5                  10                  15      
Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly
            20                  25                  30          
Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn
        35                  40                  45              
Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile
    50                  55                  60                  
Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro
65                  70                  75          


<210> 3
<211> 912
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-15-Ralphasushi_GS linker_BLV1H12 light chain

<400> 3
atcacctgcc cacctccaat gagcgtggag cacgcagaca tctgggtgaa gtcttacagc 60
ctgtattccc gggagagata catctgcaac tctggcttca agcggaaggc cggcaccagc 120
tccctgacag agtgcgtgct gaacaaggcc accaatgtgg cccactggac aactccttcc 180
ctgaaatgta ttagagaccc cgccctggtg catcagagac ctgccccccc tggtggaggc 240
ggttcaggcg gaggtggatc ccaggccgtc ctgaaccagc caagcagcgt ctccgggtct 300
ctggggcagc gggtctcaat cacctgtagc gggtcttcct ccaatgtcgg caacggctac 360
gtgtcttggt atcagctgat ccctggcagt gccccacgaa ccctgatcta cggcgacaca 420
tccagagctt ctggggtccc cgatcggttc tcagggagca gatccggaaa cacagctact 480
ctgaccatca gctccctgca ggctgaggac gaagcagatt atttctgcgc atctgccgag 540
gactctagtt caaatgccgt gtttggaagc ggcaccacac tgacagtcct aggtcagccc 600
aaggctgccc cctcggtcac tctgttcccg ccctcctctg aggagcttca agccaacaag 660
gccacactgg tgtgtctcat aagtgacttc tacccgggag ccgtgacagt ggcctggaag 720
gcagatagca gccccgtcaa ggcgggagtg gagaccacca caccctccaa acaaagcaac 780
aacaagtacg cggccagcag ctatctgagc ctgacgcctg agcagtggaa gtcccacaga 840
agctacagct gccaggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctaca 900
gaatgttcat aa                                                     912

<210> 4
<211> 524
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL2 receptor subunit beta

<400> 4
Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn
 1               5                  10                  15      
Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys
            20                  25                  30          
Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu
        35                  40                  45              
Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly
    50                  55                  60                  
Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg
65                  70                  75                  80  
Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp
                85                  90                  95      
Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln
            100                 105                 110         
Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser
        115                 120                 125             
Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr
    130                 135                 140                 
Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys
145                 150                 155                 160 
Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln
                165                 170                 175     
Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr
            180                 185                 190         
Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala
        195                 200                 205             
Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu
    210                 215                 220                 
Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys
225                 230                 235                 240 
Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro
                245                 250                 255     
Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp
            260                 265                 270         
Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro
        275                 280                 285             
Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp
    290                 295                 300                 
Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala
305                 310                 315                 320 
Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly
                325                 330                 335     
Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln
            340                 345                 350         
Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly
        355                 360                 365             
Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu
    370                 375                 380                 
Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu
385                 390                 395                 400 
Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr
                405                 410                 415     
Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu
            420                 425                 430         
Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro
        435                 440                 445             
Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu
    450                 455                 460                 
Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu
465                 470                 475                 480 
Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg
                485                 490                 495     
Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu
            500                 505                 510         
Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val
        515                 520                 


<210> 5
<211> 513
<212> DNA
<213> Artificial Sequence

<220> 
<223> BLV1H 12 heavy chain

<400> 5
caggtccagc tgagagagag cggcccttca ctggtcaagc catcccagac actgagcctg 60
acatgcacag caagcgggtt ttcactgagc gacaaggcag tgggatgggt ccgacaggca 120
ccaggaaaag ccctggaatg gctgggcagc atcgataccg gcgggaacac agggtacaat 180
cccggactga agagcagact gtccattacc aaggacaact ctaaaagtca ggtgtcactg 240
agcgtgagct ccgtcaccac agaggatagt gcaacttact attgcacctc tgtgcaccag 300
gaaactaaga aataccagag ctgtcctgac ggctatcggg agagatctga ttgcagtaat 360
aggccagctt gtggcacatc cgactgctgt cgcgtgtctg tcttcgggaa ctgcctgact 420
accctgcctg tgtcctactc ttatacctac aattatgaat ggcatgtgga tgtctgggga 480
cagggcctgc tggtgacagt ctctagtgct agc                              513

<210> 6
<211> 1557
<212> DNA
<213> Artificial Sequence

<220> 
<223> (Sig Seq- VRegion - CH1CH2CH3) BLV1H12 V in human
      IgG

<400> 6
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag 60
gtgcagctgc gggagtcggg ccccagcctg atgaagccgt cacagaccct ctccctcacc 120
tgcacggtct ctggatcttc attgaacgac aagtctgtag gctgggtccg ccaggctcca 180
gggaaggcgc tgcagtggct cggtagtgtg gacactagtg gaaacacaga ctataaccca 240
ggcctgaaat cccggctcag catcaccaag gacaactcca agagccgaat ctctcttaca 300
gtgactggca tgacaactga agactcggcc acatactact gtacttctgt gcaccaggaa 360
acaaaaaaat accaaagttg tccggaggat tatacttata atccacgttg ccctcagcag 420
tatggttgga gtgactgtga ttgtatgggc gataggtttg ggggttactg tcgacaggat 480
ggttgtagta attatagtta tacttacaat tacgaatggc acgtcgatgt ctggggccaa 540
ggactcctgg tcaccgtctc ctcagctagc accaagggcc catcggtctt ccccctggca 600
ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac 660
ttccccgaac ctgtgacggt ctcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc 720
ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc 780
tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc 840
aaggtggaca agagagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc 900
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 960
accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa 1020
gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca 1080
aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg 1140
caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca 1200
gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac 1260
accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc 1320
aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac 1380
aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctatagcaag 1440
ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat 1500
gaggctctgc acaaccacta cacgcagaag agcctctccc tgtccccggg taaatga    1557

<210> 7
<211> 823
<212> DNA
<213> Artificial Sequence

<220> 
<223> B15 variable region plus signal peptide

<400> 7
gaattccacc atgggatggt catgtatcat cctttttcta gtagcaactg caaccggagt 60
acattcccag gtgcagctgc gcgagtcggg ccccagcctg gtgaagccgt cacagaccct 120
ctcgctcacc tgcacggcct ctggattctc attgagcgac aaggctgtag gctgggtccg 180
ccaggctcca gggaaggcgc tggagtggct cggtagtata gacactggtg gaaacacagg 240
ctataaccca ggcctgaaat cccggctcag catcaccaag gacaactcca agagtcaagt 300
ctctctgtca gtgagcagcg tgacaactga ggactcggcc acatactact gtacttctgt 360
gcaccaggaa acaaaaaaat accaaaccgg tggatcaaac tgggtgaatg taataagtga 420
tttgaaaaaa attgaagatc ttattcaatc tatgcatatt gatgctactt tatatacgga 480
aagtgatgtt caccccagtt gcaaagtaac agcaatgaag tgctttctct tggagttaca 540
agttatttca cttgagtccg gagatgcaag tattcatgat acagtagaaa atctgatcat 600
cctagcaaac aacagtttgt cttctaatgg gaatgtaaca gaatctggat gcaaagaatg 660
tgaggaactg gaggaaaaaa atattaaaga atttttgcag agttttgtac atattgtcca 720
aatgttcatc aacacttctg gttcaggatc ctatacttac aattacgaat ggcacgtcga 780
tgtctggggc caaggactcc tggtcaccgt ctcctcagct agc                   823

<210> 8
<211> 672
<212> DNA
<213> Artificial Sequence

<220> 
<223> BLV1H12 Light Chain

<400> 8
tcacgaattc gcaggccgtc ctgaaccagc caagcagcgt ctccgggtct ctggggcagc 60
gggtctcaat cacctgtagc gggtcttcct ccaatgtcgg caacggctac gtgtcttggt 120
atcagctgat ccctggcagt gccccacgaa ccctgatcta cggcgacaca tccagagctt 180
ctggggtccc cgatcggttc tcagggagca gatccggaaa cacagctact ctgaccatca 240
gctccctgca ggctgaggac gaagcagatt atttctgcgc atctgccgag gactctagtt 300
caaatgccgt gtttggaagc ggcaccacac tgacagtcct ggggcagccc aagagtcccc 360
cttcagtgac tctgttccca ccctctaccg aggaactgaa cggaaacaag gccacactgg 420
tgtgtctgat cagcgacttt taccctggat ccgtcactgt ggtctggaag gcagatggca 480
gcacaattac taggaacgtg gaaactaccc gcgcctccaa gcagtctaat agtaaatacg 540
ccgccagctc ctatctgagc ctgacctcta gtgattggaa gtccaaaggg tcatatagct 600
gcgaagtgac ccatgaaggc tcaaccgtga ctaagactgt gaaaccatcc gagtgctcct 660
aggctagctg gc                                                     672

<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV1H12 ascending stalk region

<400> 9
Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser
 1               5                  10          


<210> 10
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV1H12 decending stalk region

<400> 10
Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val
 1               5                  10          


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> V2 alternative sequence

<400> 11
Trp Gly Gln Gly Leu Leu Val Thr Val Ser Ser
 1               5                  10      


<210> 12
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> V1 Alternative B sequence of VH4-34_Q5RQ6E

<400> 12
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95  


<210> 13
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> V1 Alternative B sequence of
      VH4-34_CDR1-G31DY32K_Q5RQ6E

<400> 13
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95  


<210> 14
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> V1 Alternative B sequence of
      VH4-34_CDR2-E50S_Q5RQ6E

<400> 14
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95  


<210> 15
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized: V1 Alternative B sequence of
      VH4-34_CDR1-G31DY32K_CDR2-E50S_Q5RQ6E

<400> 15
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95  


<210> 16
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized: V1 Alternative B sequence of
      VH4-34_CDR1-Cow_Q5RQ6E

<400> 16
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95  


<210> 17
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized: V1 Alternative B sequence of
      VH4-34_CDR2-Cow_Q5RQ6E

<400> 17
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Leu Gly Ser Ile Asp
            20                  25                  30          
Thr Gly Gly Asn Thr Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile
        35                  40                  45              
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95  


<210> 18
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized: V1 Alternative B sequence of
      VH4-34_CDR1-Cow_CDR2-E50S_Q5RQ6E

<400> 18
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95  


<210> 19
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized: V1 Alternative N sequence of
      VH4-34_CDR1-Cow_CDR2-Cow_Q5RQ6E

<400> 19
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95  


<210> 20
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> V2 alternative sequence

<400> 20
Trp Gly His Gly Thr Ala Val Thr Val Ser Ser
 1               5                  10      


<210> 21
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> V2 alternative sequence

<400> 21
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
 1               5                  10      


<210> 22
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> V2 alternative sequence

<400> 22
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
 1               5                  10      


<210> 23
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> V2 alternative sequence

<400> 23
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
 1               5                  10      


<210> 24
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> V2 alternative sequence

<400> 24
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser
 1               5                  10      


<210> 25
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthesized: ultralong CDR3 sequence (BLV1H12)

<400> 25
Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Cys Pro Asp Gly Tyr
 1               5                  10                  15      
Arg Glu Arg Ser Asp Cys Ser Asn Arg Pro Ala Cys Gly Thr Ser Asp
            20                  25                  30          
Cys Cys Arg Val Ser Val Phe Gly Asn Cys Leu Thr Thr Leu Pro Val
        35                  40                  45              
Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp
    50                  55                  60      


<210> 26
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV1H12 Heavy Chain

<400> 26
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Thr
                85                  90                  95      
Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Cys Pro Asp Gly Tyr
            100                 105                 110         
Arg Glu Arg Ser Asp Cys Ser Asn Arg Pro Ala Cys Gly Thr Ser Asp
        115                 120                 125             
Cys Cys Arg Val Ser Val Phe Gly Asn Cys Leu Thr Thr Leu Pro Val
    130                 135                 140                 
Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp Gly
145                 150                 155                 160 
Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys
                165                 170                 175     
Val Tyr Pro Leu Ser Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr Val
            180                 185                 190         
Thr Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val
        195                 200                 205             
Thr Trp Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala
    210                 215                 220                 
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val
225                 230                 235                 240 
Pro Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro
                245                 250                 255     
Ala Ser Ser Thr Lys Val Asp Lys Ala Val Glu Pro Lys Ser Cys Asp
            260                 265                 270         
Gly Ser
        


<210> 27
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV1H12 Light Chain

<400> 27
Gln Ala Val Leu Asn Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln
 1               5                  10                  15      
Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Asn Gly
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Leu Ile Pro Gly Ser Ala Pro Arg Thr Leu
        35                  40                  45              
Ile Tyr Gly Asp Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ser Ala Glu Asp Ser Ser
                85                  90                  95      
Ser Asn Ala Val Phe Gly Ser Gly Thr Thr Leu Thr Val Leu Gly Gln
            100                 105                 110         
Pro Lys Ser Pro Pro Ser Val Thr Leu Phe Pro Pro Ser Thr Glu Glu
        115                 120                 125             
Leu Asn Gly Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140                 
Pro Gly Ser Val Thr Val Val Trp Lys Ala Asp Gly Ser Thr Ile Thr
145                 150                 155                 160 
Arg Asn Val Glu Thr Thr Arg Ala Ser Lys Gln Ser Asn Ser Lys Tyr
                165                 170                 175     
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Ser Ser Asp Trp Lys Ser Lys
            180                 185                 190         
Gly Ser Tyr Ser Cys Glu Val Thr His Glu Gly Ser Thr Val Thr Lys
        195                 200                 205             
Thr Val Lys Pro Ser Glu Cys Ser
    210                 215     


<210> 28
<211> 240
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV5B8 heavy chain

<400> 28
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Ser Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Thr
                85                  90                  95      
Thr Val His Gln Glu Thr Arg Lys Thr Cys Ser Asp Gly Tyr Ile Ala
            100                 105                 110         
Val Asp Ser Cys Gly Arg Gly Gln Ser Asp Gly Cys Val Asn Asp Cys
        115                 120                 125             
Asn Ser Cys Tyr Tyr Gly Trp Arg Asn Cys Arg Arg Gln Pro Ala Ile
    130                 135                 140                 
His Ser Tyr Glu Phe His Val Asp Ala Trp Gly Arg Gly Leu Leu Val
145                 150                 155                 160 
Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser
                165                 170                 175     
Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu
            180                 185                 190         
Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly
        195                 200                 205             
Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
    210                 215                 220                 
Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser
225                 230                 235                 240 


<210> 29
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV5B8 light chain

<400> 29
Gln Ala Val Leu Asn Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln
 1               5                  10                  15      
Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Asn Gly
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Leu Ile Pro Gly Ser Ala Pro Arg Thr Leu
        35                  40                  45              
Ile Tyr Gly Asp Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln
65                  70                  75                  80  
Ala Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ser Ala Glu Asp Ser Ser
                85                  90                  95      
Ser Asn Ala Val Phe Gly Ser Gly Thr Thr Leu Thr Val Leu Gly Gln
            100                 105                 110         
Pro Lys Ser Pro Pro Ser Val Thr Leu Phe Pro Pro Ser Thr Glu Glu
        115                 120                 125             
Leu Asn Gly Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140                 
Pro Gly Ser Val Thr Val Val Trp Lys Ala Asp Gly Ser Thr Ile Thr
145                 150                 155                 160 
Arg Asn Val Glu Thr Thr Arg Ala Ser Lys Gln Ser Asn Ser Lys Tyr
                165                 170                 175     
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Ser Ser Asp Trp Lys Ser Lys
            180                 185                 190         
Gly Ser Tyr Ser Cys Glu Val Thr His Glu Gly Ser Thr Val Thr Lys
        195                 200                 205             
Thr Val Lys Pro Ser Glu Cys Ser
    210                 215     


<210> 30
<211> 56
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV5B8 CDR3

<400> 30
Thr Val His Gln Glu Thr Arg Lys Thr Cys Ser Asp Gly Tyr Ile Ala
 1               5                  10                  15      
Val Asp Ser Cys Gly Arg Gly Gln Ser Asp Gly Cys Val Asn Asp Cys
            20                  25                  30          
Asn Ser Cys Tyr Tyr Gly Trp Arg Asn Cys Arg Arg Gln Pro Ala Ile
        35                  40                  45              
His Ser Tyr Glu Phe His Val Asp
    50                  55      


<210> 31
<211> 57
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV5D3 CDR3

<400> 31
Ser Val Thr Gln Arg Thr His Val Ser Arg Ser Cys Pro Asp Gly Cys
 1               5                  10                  15      
Ser Asp Gly Asp Gly Cys Val Asp Gly Cys Cys Cys Ser Ala Tyr Arg
            20                  25                  30          
Cys Tyr Thr Pro Gly Val Arg Asp Leu Ser Cys Thr Ser Tyr Ser Ile
        35                  40                  45              
Thr Tyr Thr Tyr Glu Trp Asn Val Asp
    50                  55          


<210> 32
<211> 58
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV8C11 CDR3

<400> 32
Thr Val His Gln Lys Thr Thr Arg Lys Thr Cys Cys Ser Asp Ala Tyr
 1               5                  10                  15      
Arg Tyr Asp Ser Gly Cys Gly Ser Gly Cys Asp Cys Cys Gly Ala Asp
            20                  25                  30          
Cys Tyr Val Phe Gly Ala Cys Thr Phe Gly Leu Asp Ser Ser Tyr Ser
        35                  40                  45              
Tyr Ile Tyr Ile Tyr Gln Trp Tyr Val Asp
    50                  55              


<210> 33
<211> 56
<212> PRT
<213> Artificial Sequence

<220> 
<223> BF4E9 CDR3

<400> 33
Thr Val His Gln Ile Phe Cys Pro Asp Gly Tyr Ser Tyr Gly Tyr Gly
 1               5                  10                  15      
Cys Gly Tyr Gly Tyr Gly Cys Ser Gly Tyr Asp Cys Tyr Gly Tyr Gly
            20                  25                  30          
Gly Tyr Gly Tyr Gly Gly Tyr Gly Gly Tyr Ser Ser Tyr Ser Tyr Ser
        35                  40                  45              
Tyr Ser Tyr Glu Tyr Tyr Gly Asp
    50                  55      


<210> 34
<211> 48
<212> PRT
<213> Artificial Sequence

<220> 
<223> BF1H1 CDR3

<400> 34
Thr Val His Pro Ser Pro Asp Gly Tyr Ser Tyr Gly Tyr Gly Cys Gly
 1               5                  10                  15      
Tyr Gly Tyr Gly Cys Ser Gly Tyr Asp Cys Tyr Gly Tyr Gly Gly Tyr
            20                  25                  30          
Gly Tyr Gly Gly Tyr Gly Gly Tyr Ser Ser Tyr Ser Tyr Ser Tyr Ser
        35                  40                  45              


<210> 35
<211> 48
<212> PRT
<213> Artificial Sequence

<220> 
<223> F18 CDR3

<400> 35
Thr Val His Gln Ile Arg Cys Pro Asp Gly Tyr Gly Tyr Gly Tyr Gly
 1               5                  10                  15      
Cys Gly Tyr Gly Ser Tyr Gly Tyr Ser Gly Tyr Asp Cys Tyr Gly Tyr
            20                  25                  30          
Gly Gly Tyr Gly Gly Tyr Gly Gly Tyr Gly Gly Tyr Ser Ser Tyr Ser
        35                  40                  45              


<210> 36
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 36
Thr Thr Val His Gln
 1               5  


<210> 37
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 37
Thr Ser Val His Gln
 1               5  


<210> 38
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 38
Ser Ser Val Thr Gln
 1               5  


<210> 39
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 39
Ser Thr Val His Gln
 1               5  


<210> 40
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 40
Ala Thr Val Arg Gln
 1               5  


<210> 41
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 41
Thr Thr Val Tyr Gln
 1               5  


<210> 42
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 42
Ser Pro Val His Gln
 1               5  


<210> 43
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 43
Ala Thr Val Tyr Gln
 1               5  


<210> 44
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 44
Thr Ala Val Tyr Gln
 1               5  


<210> 45
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 45
Thr Asn Val His Gln
 1               5  


<210> 46
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 46
Ala Thr Val His Gln
 1               5  


<210> 47
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 47
Ser Thr Val Tyr Gln
 1               5  


<210> 48
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 48
Thr Ile Val His Gln
 1               5  


<210> 49
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 49
Ala Ile Val Tyr Gln
 1               5  


<210> 50
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 50
Thr Thr Val Phe Gln
 1               5  


<210> 51
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 51
Ala Ala Val Phe Gln
 1               5  


<210> 52
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 52
Gly Thr Val His Gln
 1               5  


<210> 53
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 53
Ala Ser Val His Gln
 1               5  


<210> 54
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 54
Thr Ala Val Phe Gln
 1               5  


<210> 55
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 55
Ala Thr Val Phe Gln
 1               5  


<210> 56
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 56
Ala Ala Ala His Gln
 1               5  


<210> 57
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 57
Val Trp Tyr Gln
 1              


<210> 58
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 58
Gly Thr Val Phe Gln
 1               5  


<210> 59
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 59
Thr Ala Val His Gln
 1               5  


<210> 60
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 60
Ile Thr Val His Gln
 1               5  


<210> 61
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 61
Ile Thr Ala His Gln
 1               5  


<210> 62
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 62
Val Thr Val His Gln
 1               5  


<210> 63
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 63
Ala Ala Val His Gln
 1               5  


<210> 64
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 64
Gly Thr Val Tyr Gln
 1               5  


<210> 65
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 65
Thr Thr Val Leu Gln
 1               5  


<210> 66
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 66
Thr Thr Thr His Gln
 1               5  


<210> 67
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 67
Thr Thr Asp Tyr Gln
 1               5  


<210> 68
<211> 99
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human heavy chain variable region sequence VH4-39

<400> 68
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser
            20                  25                  30          
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg
            


<210> 69
<211> 96
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human heavy chain variable region sequence 4-59*03

<400> 69
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      


<210> 70
<211> 97
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human heavy chain variable region sequence 4-34*02

<400> 70
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg
    


<210> 71
<211> 97
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human heavy chain variable region sequence 4-34*09

<400> 71
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg
    


<210> 72
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 72
Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln
 1               5                  10      


<210> 73
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 73
Val His Gln Glu Thr Lys Lys Tyr Gln
 1               5                  


<210> 74
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 74
Ile His Ser Tyr Glu Phe
 1               5      


<210> 75
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 75
Ser Tyr Glu Phe
 1              


<210> 76
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 76
Tyr Thr Tyr Asn Tyr Glu
 1               5      


<210> 77
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 77
Tyr Thr Tyr Asn Tyr Glu Trp
 1               5          


<210> 78
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 78
Ser Tyr Thr Tyr Asn Tyr Glu Trp
 1               5              


<210> 79
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 79
Thr Tyr Asn Tyr Glu Trp
 1               5      


<210> 80
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 80
Ser Tyr Thr Tyr
 1              


<210> 81
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 81
Gly Ser Lys His Arg Leu Arg Asp Tyr Phe Leu Tyr Asn Glu
 1               5                  10                  


<210> 82
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 82
Gly Ser Lys His Arg Leu Arg Asp Tyr Phe Leu Tyr Asn
 1               5                  10              


<210> 83
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 83
Gly Ser Lys His Arg Leu Arg Asp Tyr Phe Leu Tyr
 1               5                  10          


<210> 84
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 84
Gly Ser Lys His Arg Leu Arg Asp Tyr Phe Leu
 1               5                  10      


<210> 85
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 85
Gly Ser Lys His Arg Leu Arg Asp Tyr Phe
 1               5                  10  


<210> 86
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 86
Gly Ser Lys His Arg Leu Arg Asp Tyr
 1               5                  


<210> 87
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 87
Gly Ser Lys His Arg Leu Arg Asp
 1               5              


<210> 88
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 88
Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn Tyr
 1               5                  10              


<210> 89
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 89
Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn
 1               5                  10          


<210> 90
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 90
Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr
 1               5                  10      


<210> 91
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 91
Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly
 1               5                  10  


<210> 92
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 92
Glu Ala Gly Gly Pro Asp Tyr Arg Asn
 1               5                  


<210> 93
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 93
Glu Ala Gly Gly Pro Asp Tyr Arg
 1               5              


<210> 94
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 94
Glu Ala Gly Gly Pro Asp Tyr
 1               5          


<210> 95
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 95
Glu Ala Gly Gly Pro Asp
 1               5      


<210> 96
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 96
Glu Ala Gly Gly Pro Ile Trp His Asp Asp Val Lys Tyr
 1               5                  10              


<210> 97
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 97
Glu Ala Gly Gly Pro Ile Trp His Asp Asp Val Lys
 1               5                  10          


<210> 98
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 98
Glu Ala Gly Gly Pro Ile Trp His Asp Asp Val
 1               5                  10      


<210> 99
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 99
Glu Ala Gly Gly Pro Ile Trp His Asp Asp
 1               5                  10  


<210> 100
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 100
Glu Ala Gly Gly Pro Ile Trp His Asp
 1               5                  


<210> 101
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 101
Glu Ala Gly Gly Pro Ile Trp His
 1               5              


<210> 102
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 102
Glu Ala Gly Gly Pro Ile Trp
 1               5          


<210> 103
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 103
Glu Ala Gly Gly Pro Ile
 1               5      


<210> 104
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 104
Gly Thr Asp Tyr Thr Ile Asp Asp Gln Gly Ile
 1               5                  10      


<210> 105
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 105
Gly Thr Asp Tyr Thr Ile Asp Asp Gln Gly
 1               5                  10  


<210> 106
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 106
Gly Thr Asp Tyr Thr Ile Asp Asp Gln
 1               5                  


<210> 107
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 107
Gly Thr Asp Tyr Thr Ile Asp Asp
 1               5              


<210> 108
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 108
Gly Thr Asp Tyr Thr Ile Asp
 1               5          


<210> 109
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 109
Gly Thr Asp Tyr Thr Ile
 1               5      


<210> 110
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 110
Asp Lys Gly Asp Ser Asp Tyr Asp Tyr Asn Leu
 1               5                  10      


<210> 111
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 111
Asp Lys Gly Asp Ser Asp Tyr Asp Tyr Asn
 1               5                  10  


<210> 112
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 112
Asp Lys Gly Asp Ser Asp Tyr Asp Tyr
 1               5                  


<210> 113
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 113
Asp Lys Gly Asp Ser Asp Tyr Asp
 1               5              


<210> 114
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 114
Asp Lys Gly Asp Ser Asp Tyr
 1               5          


<210> 115
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 115
Asp Lys Gly Asp Ser Asp
 1               5      


<210> 116
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 116
Tyr Gly Pro Asn Tyr Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp
 1               5                  10                  15      
Val
    


<210> 117
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 117
Gly Pro Asn Tyr Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp Val
 1               5                  10                  15      


<210> 118
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 118
Pro Asn Tyr Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp Val
 1               5                  10                  15  


<210> 119
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 119
Asn Tyr Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp Val
 1               5                  10                  


<210> 120
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 120
Tyr Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp Val
 1               5                  10              


<210> 121
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Strand

<400> 121
Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp Val
 1               5                  10          


<210> 122
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 122
Tyr Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10                  15  


<210> 123
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 123
Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10                  


<210> 124
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 124
Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10              


<210> 125
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 125
Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10          


<210> 126
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 126
Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10      


<210> 127
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 127
Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10  


<210> 128
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 128
Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  


<210> 129
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 129
Tyr Asp Phe Asn Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10                  15  


<210> 130
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 130
Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10                  


<210> 131
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 131
Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10              


<210> 132
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 132
Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10          


<210> 133
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 133
Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10      


<210> 134
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 134
Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val
 1               5                  10  


<210> 135
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 135
Gln Gly Ile Arg Tyr Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val
 1               5                  10                  15      


<210> 136
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 136
Gly Ile Arg Tyr Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val
 1               5                  10                  15  


<210> 137
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 137
Ile Arg Tyr Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val
 1               5                  10                  


<210> 138
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 138
Arg Tyr Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val
 1               5                  10              


<210> 139
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 139
Tyr Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val
 1               5                  10          


<210> 140
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 140
Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val
 1               5                  10      


<210> 141
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 141
Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val
 1               5                  10  


<210> 142
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 142
Ser Gly Thr Phe Trp Tyr Phe Asp Val
 1               5                  


<210> 143
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 143
Gly Thr Phe Trp Tyr Phe Asp Val
 1               5              


<210> 144
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 144
Tyr Asn Leu Gly Tyr Ser Tyr Phe Tyr Tyr Met Asp Gly
 1               5                  10              


<210> 145
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 145
Asn Leu Gly Tyr Ser Tyr Phe Tyr Tyr Met Asp Gly
 1               5                  10          


<210> 146
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 146
Leu Gly Tyr Ser Tyr Phe Tyr Tyr Met Asp Gly
 1               5                  10      


<210> 147
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 147
Gly Tyr Ser Tyr Phe Tyr Tyr Met Asp Gly
 1               5                  10  


<210> 148
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 148
Tyr Ser Tyr Phe Tyr Tyr Met Asp Gly
 1               5                  


<210> 149
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending Stalk Strand

<400> 149
Ser Tyr Phe Tyr Tyr Met Asp Gly
 1               5              


<210> 150
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 150
Gly Ser
 1      


<210> 151
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 151
Gly Gly Ser
 1          


<210> 152
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 152
Gly Gly Ser Gly Gly Ser
 1               5      


<210> 153
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 153
Gly Gly Ser Gly Gly Ser Gly Gly Ser
 1               5                  


<210> 154
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 154
Gly Gly Gly Gly Ser
 1               5  


<210> 155
<211> 662
<212> DNA
<213> Artificial Sequence

<220> 
<223> human light chain lambda region

<400> 155
tcacgaattc gcaggccgtc ctgaaccagc caagcagcgt ctccgggtct ctggggcagc 60
gggtctcaat cacctgtagc gggtcttcct ccaatgtcgg caacggctac gtgtcttggt 120
atcagctgat ccctggcagt gccccacgaa ccctgatcta cggcgacaca tccagagctt 180
ctggggtccc cgatcggttc tcagggagca gatccggaaa cacagctact ctgaccatca 240
gctccctgca ggctgaggac gaagcagatt atttctgcgc atctgccgag gactctagtt 300
caaatgccgt gtttggaagc ggcaccacac tgacagtcct aggtcagccc aaggctgccc 360
cctcggtcac tctgttcccg ccctcctctg aggagcttca agccaacaag gccacactgg 420
tgtgtctcat aagtgacttc tacccgggag ccgtgacagt ggcctggaag gcagatagca 480
gccccgtcaa ggcgggagtg gagaccacca caccctccaa acaaagcaac aacaagtacg 540
cggccagcag ctatctgagc ctgacgcctg agcagtggaa gtcccacaga agctacagct 600
gccaggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctaca gaatgttcat 660
aa                                                                662

<210> 156
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> human VL1-51

<400> 156
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
 1               5                  10                  15      
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65                  70                  75                  80  
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Ala Glu Asp Ser Ser
                85                  90                  95      
Ser Asn Ala Val Phe Gly Ser Gly Thr Thr Leu Thr Val Leu Gly Gln
            100                 105                 110         
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu
        115                 120                 125             
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140                 
Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys
145                 150                 155                 160 
Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr
                165                 170                 175     
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His
            180                 185                 190         
Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys
        195                 200                 205             
Thr Val Ala Pro Thr Glu Cys Ser
    210                 215     


<210> 157
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> BLV1H12 ascending stalk region

<400> 157
tgtacttctg tgcaccagga aacaaaaaaa taccaaacc                        39

<210> 158
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV1H12 ascending stalk region

<400> 158
Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Thr
 1               5                  10          


<210> 159
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV1H12 ascending stalk region

<400> 159
Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Thr
 1               5                  10              


<210> 160
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Descending stalk region

<400> 160
tcctatactt acaattacga atggcacgtc gatgtctgg                        39

<210> 161
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Descending stalk region

<400> 161
Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
 1               5                  10              


<210> 162
<211> 117
<212> DNA
<213> Artificial Sequence

<220> 
<223> BLV1H12 knob sequence

<400> 162
tgtccggagg attatactta taatccacgt tgccctcagc agtatggttg gagtgactgt 60
gattgtatgg gcgataggtt tgggggttac tgtcgacagg atggttgtag taattat    117

<210> 163
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Coding sequencing for N-terminal GGS linker

<400> 163
ggtggatca                                                         9

<210> 164
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Coding sequence for C-terminal GSG linker

<400> 164
ggttcagga                                                         9

<210> 165
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL2

<400> 165
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His
 1               5                  10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys
            20                  25                  30          
Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile
        115                 120                 125             
Ile Ser Thr Leu Thr
    130             


<210> 166
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL2 coding sequence

<400> 166
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat 60
ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc 120
acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa 180
gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta 240
agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa 300
acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga 360
tggattacct tttgtcaaag catcatctca acactgact                        399

<210> 167
<211> 513
<212> DNA
<213> Artificial Sequence

<220> 
<223> Chimeric ultralong bovine heavy chain sequence

<400> 167
caggtgcagc tgcgggagtc gggccccagc ctgatgaagc cgtcacagac cctctccctc 60
acctgcacgg tctctggatc ttcattgaac gacaagtctg taggctgggt ccgccaggct 120
ccagggaagg cgctgcagtg gctcggtagt gtggacacta gtggaaacac agactataac 180
ccaggcctga aatcccggct cagcatcacc aaggacaact ccaagagccg aatctctctt 240
acagtgactg gcatgacaac tgaagactcg gccacatact actgtacttc tgtgcaccag 300
gaaacaaaaa aataccaaag ttgtccggag gattatactt ataatccacg ttgccctcag 360
cagtatggtt ggagtgactg tgattgtatg ggcgataggt ttgggggtta ctgtcgacag 420
gatggttgta gtaattatag ttatacttac aattacgaat ggcacgtcga tgtctggggc 480
caaggactcc tggtcaccgt ctcctcagct agc                              513

<210> 168
<211> 651
<212> DNA
<213> Artificial Sequence

<220> 
<223> BLV1H12 Light Chain-

<400> 168
caggccgtcc tgaaccagcc aagcagcgtc tccgggtctc tggggcagcg ggtctcaatc 60
acctgtagcg ggtcttcctc caatgtcggc aacggctacg tgtcttggta tcagctgatc 120
cctggcagtg ccccacgaac cctgatctac ggcgacacat ccagagcttc tggggtcccc 180
gatcggttct cagggagcag atccggaaac acagctactc tgaccatcag ctccctgcag 240
gctgaggacg aagcagatta tttctgcgca tctgccgagg actctagttc aaatgccgtg 300
tttggaagcg gcaccacact gacagtccta ggtcagccca aggctgcccc ctcggtcact 360
ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata 420
agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag 480
gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc 540
tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg 600
catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata a          651

<210> 169
<211> 311
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human heavy chain variable region sequence 4-39

<400> 169
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc 120
cagcccccag ggaaggggct ggagtggatt gggagtatct attatagtgg gagcacctac 180
tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc 240
tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgagacac 300
acagtgaggg g                                                      311

<210> 170
<211> 288
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human heavy chain variable region sequence 4-59*03

<400> 170
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc 120
ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaac 180
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca attctccctg 240
aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcg              288

<210> 171
<211> 291
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human heavy chain variable region sequence 4-34*09

<400> 171
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc 60
acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc 120
ccagggaagg gactggagtg gattggggaa atcaatcata gtggaagcac caactacaac 180
ccgtccctca agagtcgagt taccatatca gtagacacgt ctaagaacca gttctccctg 240
aagctgagct ctgtgactgc cgcggacacg gccgtgtatt actgtgcgag a          291

<210> 172
<211> 290
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human heavy chain variable region sequence 4-34*02

<400> 172
caggtgcagc tacaacagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60
acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc 120
ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac 180
ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag            290

<210> 173
<211> 98
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human germline light chain variable region
      sequence VL1-47

<400> 173
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
            20                  25                  30          
Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Ser Gly
        


<210> 174
<211> 99
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human germline light chain variable region
      sequence VL1-40*1

<400> 174
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95      
Leu Ser Gly
            


<210> 175
<211> 98
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human germline light chain variable region
      sequence VL1-51*01

<400> 175
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
 1               5                  10                  15      
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65                  70                  75                  80  
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
                85                  90                  95      
Ser Ala
        


<210> 176
<211> 99
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human germline light chain variable region
      sequence VL2-18*02

<400> 176
Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln
 1               5                  10                  15      
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr
            20                  25                  30          
Asn Arg Val Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
                85                  90                  95      
Ser Thr Phe
            


<210> 177
<211> 296
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human germline light chain variable region
      sequence VL1-47

<400> 177
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcttgttctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcagctc 120
ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggtcc     296

<210> 178
<211> 299
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human germline light chain variable region
      sequence VL1-40*1

<400> 178
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc 60
tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag 120
cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc 180
cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc 240
caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttc  299

<210> 179
<211> 296
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human germline light chain variable region
      sequence VL1-51*01

<400> 179
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc 60
tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc 120
ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct 180
gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag 240
actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag tgctgg     296

<210> 180
<211> 297
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human germline light chain variable region
      sequence VL2-18*02

<400> 180
cagtctgccc tgactcagcc tccctccgtg tccgggtctc ctggacagtc agtcaccatc 60
tcctgcactg gaaccagcag tgacgttggt agttataacc gtgtctcctg gtaccagcag 120
cccccaggca cagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtc 180
cctgatcgct tctctgggtc caagtctggc aacacggcct ccctgaccat ctctgggctc 240
caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cactttc    297

<210> 181
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Humanized Light Chain

<400> 181
Gln Ala Val Leu Asn Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln
 1               5                  10                  15      
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Gly Asp Thr Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
65                  70                  75                  80  
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Ala Glu Asp Ser Ser
                85                  90                  95      
Ser Asn Ala Val Phe Gly Ser Gly Thr Thr Leu Thr Val Leu Gly Gln
            100                 105                 110         
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu
        115                 120                 125             
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140                 
Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys
145                 150                 155                 160 
Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr
                165                 170                 175     
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His
            180                 185                 190         
Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys
        195                 200                 205             
Thr Val Ala Pro Thr Glu Cys Ser
    210                 215     


<210> 182
<211> 94
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 V1 Region

<400> 182
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr
                85                  90                  


<210> 183
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Region

<400> 183
Cys Ser Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr
 1               5                  10              


<210> 184
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Region

<400> 184
Cys Ala Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr
 1               5                  10              


<210> 185
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ascending Stalk Region

<400> 185
Cys Thr Thr Val Tyr Gln Glu Thr Lys Lys Tyr Gln Thr
 1               5                  10              


<210> 186
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 186
Gly Ser Gly
 1          


<210> 187
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 heavy constant region with LALA
      mutation and K97R

<400> 187
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 188
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 heavy constant region with LALA
      mutation

<400> 188
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 189
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 1 Heavy Chain

<400> 189
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Ser
                85                  90                  95      
Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
                245                 250                 255     
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
            260                 265                 270         
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
        275                 280                 285             
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
    290                 295                 300                 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
305                 310                 315                 320 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                325                 330                 335     
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                565                 570                 575     
Ser Pro Gly Lys
            580 


<210> 190
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 2 Heavy Chain

<400> 190
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
                245                 250                 255     
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
            260                 265                 270         
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
        275                 280                 285             
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
    290                 295                 300                 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
305                 310                 315                 320 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                325                 330                 335     
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                565                 570                 575     
Ser Pro Gly Lys
            580 


<210> 191
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 3 Heavy Chain

<400> 191
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Thr
                85                  90                  95      
Thr Val Tyr Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
                245                 250                 255     
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
            260                 265                 270         
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
        275                 280                 285             
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
    290                 295                 300                 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
305                 310                 315                 320 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                325                 330                 335     
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                565                 570                 575     
Ser Pro Gly Lys
            580 


<210> 192
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 4 Heavy Chain

<400> 192
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ser
                85                  90                  95      
Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
                245                 250                 255     
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
            260                 265                 270         
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
        275                 280                 285             
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
    290                 295                 300                 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
305                 310                 315                 320 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                325                 330                 335     
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                565                 570                 575     
Ser Pro Gly Lys
            580 


<210> 193
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 5 Heavy Chain

<400> 193
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
                245                 250                 255     
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
            260                 265                 270         
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
        275                 280                 285             
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
    290                 295                 300                 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
305                 310                 315                 320 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                325                 330                 335     
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                565                 570                 575     
Ser Pro Gly Lys
            580 


<210> 194
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 6 Heavy Chain

<400> 194
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr
                85                  90                  95      
Thr Val Tyr Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
                245                 250                 255     
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
            260                 265                 270         
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
        275                 280                 285             
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
    290                 295                 300                 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
305                 310                 315                 320 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                325                 330                 335     
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                565                 570                 575     
Ser Pro Gly Lys
            580 


<210> 195
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> BLV1H12 Knob Sequence

<400> 195
Cys Pro Asp Gly Tyr Arg Glu Arg Ser Asp Cys Ser Asn Arg Pro Ala
 1               5                  10                  15      
Cys Gly Thr Ser Asp Cys Cys Arg Val Ser Val Phe Gly Asn Cys Leu
            20                  25                  30          
Thr Thr Leu Pro Val Ser Tyr
        35                  


<210> 196
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human IgG1 Heavy Constant Region

<400> 196
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 197
<211> 94
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Humanized V1 Region

<400> 197
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  


<210> 198
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 7 Heavy Chain

<400> 198
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Thr
                85                  90                  95      
Ser Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
                245                 250                 255     
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
            260                 265                 270         
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
        275                 280                 285             
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
    290                 295                 300                 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
305                 310                 315                 320 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                325                 330                 335     
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                565                 570                 575     
Ser Pro Gly Lys
            580 


<210> 199
<211> 580
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 8 Heavy Chain

<400> 199
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr
                85                  90                  95      
Ser Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
                245                 250                 255     
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
            260                 265                 270         
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
        275                 280                 285             
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
    290                 295                 300                 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
305                 310                 315                 320 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn
                325                 330                 335     
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
            340                 345                 350         
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
        355                 360                 365             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
    370                 375                 380                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
385                 390                 395                 400 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
                405                 410                 415     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
            420                 425                 430         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
        435                 440                 445             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
    450                 455                 460                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
465                 470                 475                 480 
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
                485                 490                 495     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
            500                 505                 510         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
        515                 520                 525             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
    530                 535                 540                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
545                 550                 555                 560 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                565                 570                 575     
Ser Pro Gly Lys
            580 


<210> 200
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 1 Variable Heavy Region

<400> 200
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Ser
                85                  90                  95      
Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser
                245                 250 


<210> 201
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 2 Variable Heavy Region

<400> 201
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Ala
                85                  90                  95      
Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser
                245                 250 


<210> 202
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 3 Variable Heavy Region

<400> 202
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Thr
                85                  90                  95      
Thr Val Tyr Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser
                245                 250 


<210> 203
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 4 Variable Heavy Region

<400> 203
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ser
                85                  90                  95      
Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser
                245                 250 


<210> 204
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 5 Variable Heavy Region

<400> 204
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser
                245                 250 


<210> 205
<211> 250
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 6 Variable Heavy Region

<400> 205
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr
                85                  90                  95      
Thr Val Tyr Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser Asn Trp
            100                 105                 110         
Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser
        115                 120                 125             
Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser
    130                 135                 140                 
Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile
145                 150                 155                 160 
Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu
                165                 170                 175     
Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu
            180                 185                 190         
Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu
        195                 200                 205             
Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser
    210                 215                 220                 
Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp
225                 230                 235                 240 
Gly Gln Gly Leu Leu Val Thr Val Ser Ser
                245                 250 


<210> 206
<211> 145
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 1 and 4 Ultralong CDR3

<400> 206
Cys Ser Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser
 1               5                  10                  15      
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile
            20                  25                  30          
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His
        35                  40                  45              
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln
    50                  55                  60                  
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu
65                  70                  75                  80  
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val
                85                  90                  95      
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile
            100                 105                 110         
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn
        115                 120                 125             
Thr Ser Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp
    130                 135                 140                 
Val
145 


<210> 207
<211> 145
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 2 and 5 Ultralong CDR3

<400> 207
Cys Ala Thr Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser
 1               5                  10                  15      
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile
            20                  25                  30          
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His
        35                  40                  45              
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln
    50                  55                  60                  
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu
65                  70                  75                  80  
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val
                85                  90                  95      
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile
            100                 105                 110         
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn
        115                 120                 125             
Thr Ser Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp
    130                 135                 140                 
Val
145 


<210> 208
<211> 145
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 3 and 6 Ultralong CDR3

<400> 208
Cys Thr Thr Val Tyr Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser
 1               5                  10                  15      
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile
            20                  25                  30          
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His
        35                  40                  45              
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln
    50                  55                  60                  
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu
65                  70                  75                  80  
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val
                85                  90                  95      
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile
            100                 105                 110         
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn
        115                 120                 125             
Thr Ser Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp
    130                 135                 140                 
Val
145 


<210> 209
<211> 145
<212> PRT
<213> Artificial Sequence

<220> 
<223> B15 Variant 7 and 8 Ultralong CDR3

<400> 209
Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Thr Gly Gly Ser
 1               5                  10                  15      
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile
            20                  25                  30          
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His
        35                  40                  45              
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln
    50                  55                  60                  
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu
65                  70                  75                  80  
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val
                85                  90                  95      
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile
            100                 105                 110         
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn
        115                 120                 125             
Thr Ser Gly Ser Gly Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp
    130                 135                 140                 
Val
145 


<210> 210
<211> 469
<212> PRT
<213> Artificial Sequence

<220> 
<223> Control Antibody Heavy Chain (No Knob)

<400> 210
Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys
            20                  25                  30          
Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu
        35                  40                  45              
Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu
65                  70                  75                  80  
Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Thr
                85                  90                  95      
Thr Val Tyr Gln Glu Thr Lys Lys Tyr Gln Ser Gly Gly Ser Gly Gly
            100                 105                 110         
Ser Gly Gly Ser Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val
        115                 120                 125             
Trp Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
    130                 135                 140                 
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
145                 150                 155                 160 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
                165                 170                 175     
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
            180                 185                 190         
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
        195                 200                 205             
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
    210                 215                 220                 
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
225                 230                 235                 240 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala
                245                 250                 255     
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            260                 265                 270         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        275                 280                 285             
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
    290                 295                 300                 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
305                 310                 315                 320 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                325                 330                 335     
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
            340                 345                 350         
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        355                 360                 365             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
    370                 375                 380                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
385                 390                 395                 400 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                405                 410                 415     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            420                 425                 430         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        435                 440                 445             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    450                 455                 460                 
Leu Ser Pro Gly Lys
465                 


<210> 211
<211> 469
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized Control Antibody Heavy Chain (No Knob)

<400> 211
Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Thr
                85                  90                  95      
Thr Val Tyr Gln Glu Thr Lys Lys Tyr Gln Ser Gly Gly Ser Gly Gly
            100                 105                 110         
Ser Gly Gly Ser Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val
        115                 120                 125             
Trp Gly Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
    130                 135                 140                 
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
145                 150                 155                 160 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
                165                 170                 175     
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
            180                 185                 190         
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
        195                 200                 205             
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
    210                 215                 220                 
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
225                 230                 235                 240 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala
                245                 250                 255     
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            260                 265                 270         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        275                 280                 285             
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
    290                 295                 300                 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
305                 310                 315                 320 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                325                 330                 335     
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
            340                 345                 350         
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        355                 360                 365             
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
    370                 375                 380                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
385                 390                 395                 400 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                405                 410                 415     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
            420                 425                 430         
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
        435                 440                 445             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    450                 455                 460                 
Leu Ser Pro Gly Lys
465                 

