                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  Porcine-Derived Adeno-Associated Virus Capsids and Uses Thereof

<130>  21-9621.PCT

<150>  63/180,372
<151>  2021-04-27

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  1
atg tcg ttt gtt gat cac cct cca gat tgg ctt gag gag att ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa gct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ctg gga ccc gga aac ggt ctc gac cgc gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gca gac gag gtc gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt caa gag aag ctc gcg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtg gag gag cct gtt aag acg gct gct aaa gga gag cgg ata        432
Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat ccc aag aag aag aag gct cgg atc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ttg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggc aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cga acc tgg gtg ctg ccc agc tac aac aac cat cag tac ctt gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Leu Glu           
225                 230                 235                 240           

atc cac agc ggc gaa gtt gac ggc agc acc gcc aac gcc tac ttt gga        768
Ile His Ser Gly Glu Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc ccc cga gac tgg cag cga ctc gtc aac aac tac tgg gga ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc agg tcc ctc aag gtc aag atc ttc aac atc caa gtc aag gaa        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg acg cag gac ggc aca acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Thr Gln Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc caa gtg ttt acg gac gac gac tac cag ctg ccc tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acg gag ggg tgc ctg ccg gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg acg ctg aac cgt aac aac acc gac       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asp           
        355                 360                 365                       

gat ccc acc gag cgg agc agt ttc ttc tgc ctg gaa tac ttt ccc agc       1152
Asp Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg ctg cgg acg ggc aac aac ttt gaa ttc acc tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gtg ccc ttc cac tgc agc ttc gct ccc agc cag aac ctc ttc aag       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gcc aat ccg ctg gtg gac cag tac ctg tac cgc ttt gtg agc acc       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac act tcc ggt aac cta cag ttc caa aag aac ttg aag gcc aga tat       1344
Asp Thr Ser Gly Asn Leu Gln Phe Gln Lys Asn Leu Lys Ala Arg Tyr           
        435                 440                 445                       

gcc aac acc tac aag aac tgg ttt ccg ggg ccc atg tgc cgg acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tat aca ggc tcg ggc aca tat aac aac aaa ggc gtt gcc aac       1440
Gly Trp Tyr Thr Gly Ser Gly Thr Tyr Asn Asn Lys Gly Val Ala Asn           
465                 470                 475                 480           

ttt ggt act tca aac aaa atg gac cta gag gga gcc agt tac caa gta       1488
Phe Gly Thr Ser Asn Lys Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

aac cct caa ccc aac gga atg aca aac acg ctt cag gat agt aac aga       1536
Asn Pro Gln Pro Asn Gly Met Thr Asn Thr Leu Gln Asp Ser Asn Arg           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg atc ttc aac gcc cag aac gcc cct ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Pro Pro           
        515                 520                 525                       

gga act acc tct ctg tac cag gag aac aat ctt ttg ata acc agc gag       1632
Gly Thr Thr Ser Leu Tyr Gln Glu Asn Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag acg cag cct gtg aac cgc ttg gcc tac cac acc ggt ggt cag       1680
Ser Glu Thr Gln Pro Val Asn Arg Leu Ala Tyr His Thr Gly Gly Gln           
545                 550                 555                 560           

gta tca aac aac aat cag aat tca act aca cct cct acg acc gga gta       1728
Val Ser Asn Asn Asn Gln Asn Ser Thr Thr Pro Pro Thr Thr Gly Val           
                565                 570                 575               

tac aat cat cag gaa gtg ttg cct ggt agc gtg tgg atg gac aga gac       1776
Tyr Asn His Gln Glu Val Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gta tac ctt cag ggt ccc atc tgg gcc aaa atc cca gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cat ttt cat cct tct ccg gct atg ggc gga ttc gga ctc aaa cac cca       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro           
    610                 615                 620                           

ccg cct atg atg ctc atc aag aac acg ccg gta cct agc aat gtc gct       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Ala           
625                 630                 635                 640           

gcc ttt tcg gat gtg ccc gtt aaa agc ttc atc acc cag tac agc acc       1968
Ala Phe Ser Asp Val Pro Val Lys Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

gga cag gtc acg gtg gag att gaa tgg gag ctc aag aag gaa aac tcc       2016
Gly Gln Val Thr Val Glu Ile Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag agg tgg aac ccc gag atc cag tac acc aac aac tac agc aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Ser Asn Pro           
        675                 680                 685                       

aca ttc gtg gac ttt gct cca gac acc tcc ggc gag tac agg acc acg       2112
Thr Phe Val Asp Phe Ala Pro Asp Thr Ser Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgt tac ctt acc cga cct ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  2
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  2

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Leu Glu 
225                 230                 235                 240 


Ile His Ser Gly Glu Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Thr Gln Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asp 
        355                 360                 365             


Asp Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Thr Ser Gly Asn Leu Gln Phe Gln Lys Asn Leu Lys Ala Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Ser Gly Thr Tyr Asn Asn Lys Gly Val Ala Asn 
465                 470                 475                 480 


Phe Gly Thr Ser Asn Lys Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Asn Pro Gln Pro Asn Gly Met Thr Asn Thr Leu Gln Asp Ser Asn Arg 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Pro Pro 
        515                 520                 525             


Gly Thr Thr Ser Leu Tyr Gln Glu Asn Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Leu Ala Tyr His Thr Gly Gly Gln 
545                 550                 555                 560 


Val Ser Asn Asn Asn Gln Asn Ser Thr Thr Pro Pro Thr Thr Gly Val 
                565                 570                 575     


Tyr Asn His Gln Glu Val Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Ala 
625                 630                 635                 640 


Ala Phe Ser Asp Val Pro Val Lys Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Ile Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Ser Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Thr Ser Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  3
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  3
atg tcg ttt gtt gat cac ccc cca gat tgg ctt gag gag atc ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc ccg cct aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag cag gac gac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asp Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ctg gga ccc gga aac ggt ctc gac cgc gga gac cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Asp Pro Val           
    50                  55                  60                            

aac cgg gca gac gag gtc gcg cga gaa cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt caa gag aag ctc gcg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gag cct gtt aag acg gct gct aaa gga gag cgg ata        432
Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat ccc aag aag aag aag gct cgg atc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ttg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggc aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cga acc tgg gtg ctg ccc agc tac aac aac cat cag tac ctt gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Leu Glu           
225                 230                 235                 240           

atc cac agc ggc gaa gtt gac ggc agc acc gcc aac gcc tac ttt gga        768
Ile His Ser Gly Glu Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc ccc cga gac tgg cag cga ctc gtc aac aac tac tgg gga ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc agg tcc ctc aag gtc aag atc ttc aac atc caa gtc aag gaa        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg acg cag gac ggc aca acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Thr Gln Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc caa gtg ttt acg gac gac gac tac cag ctg ccc tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acg gag ggg tgc ctg ccg gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg acg ctg aac cgt aac aac acc gac       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asp           
        355                 360                 365                       

gat ccc acc gag cgg agc agt ttc ttc tgc ctg gaa tac ttt ccc agc       1152
Asp Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg ctg cgg acg gtc aac aac ttt gaa ttc acc tac agc ttc gag       1200
Lys Met Leu Arg Thr Val Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gtg ccc ttc cac tgc agc ttc gct ccc agc cag aac ctc ttc aag       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gcc aat ccg ctg gtg gac cag tac ctg tac cgc ttt gtg agc acc       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac act tcc ggt aac cta cag ttc caa aag aac ttg aag gcc aga tat       1344
Asp Thr Ser Gly Asn Leu Gln Phe Gln Lys Asn Leu Lys Ala Arg Tyr           
        435                 440                 445                       

gcc aac acc tac aag aac tgg ttt ccg ggg ccc atg tgc cgg acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tat aca ggc tcg ggc aca tat aac aac aaa ggc gtt gcc aac       1440
Gly Trp Tyr Thr Gly Ser Gly Thr Tyr Asn Asn Lys Gly Val Ala Asn           
465                 470                 475                 480           

ttt ggt act tca aac aaa atg gac cta gag gga gcc agt tac caa gta       1488
Phe Gly Thr Ser Asn Lys Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

aac cct caa ccc aac gga atg aca aac acg ctt cag gat agt aac aga       1536
Asn Pro Gln Pro Asn Gly Met Thr Asn Thr Leu Gln Asp Ser Asn Arg           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg atc ttc aac gcc cag aac gcc cct ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Pro Pro           
        515                 520                 525                       

gga act acc tct ctg tac cag gag aac aat ctt ttg ata acc agc gag       1632
Gly Thr Thr Ser Leu Tyr Gln Glu Asn Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag acg cag cct gtg aac cgc ttg gcc tac cac acc ggt ggt cag       1680
Ser Glu Thr Gln Pro Val Asn Arg Leu Ala Tyr His Thr Gly Gly Gln           
545                 550                 555                 560           

gta tca aac aac aat cag aat tca act aca cct cct acg acc gga gta       1728
Val Ser Asn Asn Asn Gln Asn Ser Thr Thr Pro Pro Thr Thr Gly Val           
                565                 570                 575               

tac aat cat cag gaa gtg ttg cct ggt agc gtg tgg atg gac aga gac       1776
Tyr Asn His Gln Glu Val Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gta tac ctt cag ggt ccc atc tgg gcc aaa atc cca gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cat ttt cat cct tct ccg gct atg ggc gga ttc gga ctc aaa cac cca       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro           
    610                 615                 620                           

ccg cct atg atg ctc atc aag aac acg ccg gta cct agc aat gtc gct       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Ala           
625                 630                 635                 640           

gcc ttt tcg gat gtg ccc gtt aaa agc ttc atc acc cag tac agc acc       1968
Ala Phe Ser Asp Val Pro Val Lys Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

gga cag gtc acg gtg gag att gaa tgg gag ctc aag aag gaa aac tcc       2016
Gly Gln Val Thr Val Glu Ile Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag agg tgg aac ccc gag atc cag tac acc aac aac tac agc aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Ser Asn Pro           
        675                 680                 685                       

aca ttc gtg gac ttt gct cca gac acc tcc ggc gag tac agg acc acg       2112
Thr Phe Val Asp Phe Ala Pro Asp Thr Ser Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgt tac ctt acc cga cct ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  4
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  4

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asp Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Asp Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Leu Glu 
225                 230                 235                 240 


Ile His Ser Gly Glu Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Thr Gln Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asp 
        355                 360                 365             


Asp Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Val Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Thr Ser Gly Asn Leu Gln Phe Gln Lys Asn Leu Lys Ala Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Ser Gly Thr Tyr Asn Asn Lys Gly Val Ala Asn 
465                 470                 475                 480 


Phe Gly Thr Ser Asn Lys Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Asn Pro Gln Pro Asn Gly Met Thr Asn Thr Leu Gln Asp Ser Asn Arg 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Pro Pro 
        515                 520                 525             


Gly Thr Thr Ser Leu Tyr Gln Glu Asn Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Leu Ala Tyr His Thr Gly Gly Gln 
545                 550                 555                 560 


Val Ser Asn Asn Asn Gln Asn Ser Thr Thr Pro Pro Thr Thr Gly Val 
                565                 570                 575     


Tyr Asn His Gln Glu Val Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Ala 
625                 630                 635                 640 


Ala Phe Ser Asp Val Pro Val Lys Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Ile Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Ser Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Thr Ser Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  5
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  5
atg tcg ttt gtt gat cac cct cca gat tgg ctt gag gag att ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ctg gga ccc gga aac gga ctc gaa cgc gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Glu Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gca gac gag gtc gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt caa gag aag ctc gcg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gag cct gtt aag acg gct gct aaa gga gag cgg ata        432
Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat ccc aag aag aag aag gct cgg atc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ttg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggc aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cga acc tgg gtg ctg ccc agc tac aac aac cat cag tac ctt gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Leu Glu           
225                 230                 235                 240           

atc cac agc ggc gaa gtt gac ggc agc acc gcc aac gcc tac ttt gga        768
Ile His Ser Gly Glu Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc ccc cga gac tgg cag cga ctc gtc aac aac tac tgg gga ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc agg tcc ctc aag gtc aag atc ttc aac atc caa gtc aag gaa        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg acg cag gac ggc aca acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Thr Gln Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc caa gtg ttt acg gac gac gac tac cag ctg ccc tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acg gag ggg tgc ctg ccg gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg acg ctg aac cgt aac aac acc gac       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asp           
        355                 360                 365                       

gat ccc acc gag cgg agc agt ttc ttc tgc ctg gaa tac ttt ccc agc       1152
Asp Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg ctg cgg acg ggc aac aac ttt gaa ttc acc tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gtg ccc ttc cac tgc agc ttc gct ccc agc cag aac ctc ttc aag       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gcc aat ccg ctg gtg gac cag tac ctg tac cgc ttt gtg agc acc       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac act tcc ggt aac cta cag ttc caa aag aac ttg aag gcc aga tat       1344
Asp Thr Ser Gly Asn Leu Gln Phe Gln Lys Asn Leu Lys Ala Arg Tyr           
        435                 440                 445                       

gcc aac acc tac aag aac tgg ttt ccg ggg ccc atg tgc cgg acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tat aca ggc tcg ggc aca tat aac aac aaa ggc gtt gcc aac       1440
Gly Trp Tyr Thr Gly Ser Gly Thr Tyr Asn Asn Lys Gly Val Ala Asn           
465                 470                 475                 480           

ttt ggt act tca aac aaa atg gac cta gag gga gcc agt tac caa gta       1488
Phe Gly Thr Ser Asn Lys Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

aac cct caa ccc aac gga atg aca aac acg ctt cag gat agt aac aga       1536
Asn Pro Gln Pro Asn Gly Met Thr Asn Thr Leu Gln Asp Ser Asn Arg           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg atc ttc aac gcc cag aac gcc cct ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Pro Pro           
        515                 520                 525                       

gga act acc tct ctg tac cag gag aac aat ctt ttg ata acc agc gag       1632
Gly Thr Thr Ser Leu Tyr Gln Glu Asn Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag acg cag cct gtg aac cgc ttg gcc tac cac acc ggt ggt cag       1680
Ser Glu Thr Gln Pro Val Asn Arg Leu Ala Tyr His Thr Gly Gly Gln           
545                 550                 555                 560           

gta tca aac aac aat cag aat tca act aca cct cct acg acc gga gta       1728
Val Ser Asn Asn Asn Gln Asn Ser Thr Thr Pro Pro Thr Thr Gly Val           
                565                 570                 575               

tac aat cat cag gaa gtg ttg cct ggt agc gtg tgg atg gac aga gac       1776
Tyr Asn His Gln Glu Val Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gta tac ctt cag ggt ccc atc tgg gcc aaa atc cca gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cat ttt cat cct tct ccg gct atg ggc gga ttc gga ctc aaa cac cca       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro           
    610                 615                 620                           

ccg cct atg atg ctc atc aag aac acg ccg gta cct agc aat gtc gct       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Ala           
625                 630                 635                 640           

gcc ttt tcg gat gtg ccc gtt aaa agc ttc atc acc cag tac agc acc       1968
Ala Phe Ser Asp Val Pro Val Lys Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

gga cag gtc acg gtg gag att gaa tgg gag ctc aag aag gaa aac tcc       2016
Gly Gln Val Thr Val Glu Ile Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag agg tgg aac ccc gag atc cag tac acc aac aac tac agc aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Ser Asn Pro           
        675                 680                 685                       

aca ttc gtg gac ttt gct cca gac acc tcc ggc gag tac agg acc acg       2112
Thr Phe Val Asp Phe Ala Pro Asp Thr Ser Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgt tac ctt acc cga cct ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  6
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  6

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Glu Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Leu Glu 
225                 230                 235                 240 


Ile His Ser Gly Glu Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Thr Gln Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asp 
        355                 360                 365             


Asp Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Thr Ser Gly Asn Leu Gln Phe Gln Lys Asn Leu Lys Ala Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Ser Gly Thr Tyr Asn Asn Lys Gly Val Ala Asn 
465                 470                 475                 480 


Phe Gly Thr Ser Asn Lys Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Asn Pro Gln Pro Asn Gly Met Thr Asn Thr Leu Gln Asp Ser Asn Arg 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Pro Pro 
        515                 520                 525             


Gly Thr Thr Ser Leu Tyr Gln Glu Asn Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Leu Ala Tyr His Thr Gly Gly Gln 
545                 550                 555                 560 


Val Ser Asn Asn Asn Gln Asn Ser Thr Thr Pro Pro Thr Thr Gly Val 
                565                 570                 575     


Tyr Asn His Gln Glu Val Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Ala 
625                 630                 635                 640 


Ala Phe Ser Asp Val Pro Val Lys Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Ile Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Ser Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Thr Ser Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  7
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  7
atg tcg ttt gtt gat cac ccc cca gat tgg ctt gag gag atc ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ctg gga ccc gga aac ggt ctc gac cgc gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gca gac gag gtc gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt caa gag aag ctc gcg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gag cct gtt aag acg gct gct aaa gga gag cgg ata        432
Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat ccc aag aag aag aag gct cgg atc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ttg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggc aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cga acc tgg gtg ctg ccc agc tac aac aac cat cag tac ctt gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Leu Glu           
225                 230                 235                 240           

atc cac agc ggc gaa gtt gac ggc agc acc gcc aac gcc tac ttt gga        768
Ile His Ser Gly Glu Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc ccc cga gac tgg cag cga ctc gtc aac aac tac tgg gga ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc agg tcc ctc aag gtc aag atc ttc aac atc caa gtc aag gaa        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg acg cag gac ggc aca acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Thr Gln Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc caa gtg ttt acg gac gac gac tac cag ctg ccc tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acg gag ggg tgc ctg ccg gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg acg ctg aac cgt aac aac acc gac       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asp           
        355                 360                 365                       

gat ccc acc gag cgg agc agt ttc ttc tgc ctg gaa tac ttt ccc agc       1152
Asp Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg ctg cgg acg ggc aac aac ttt gaa ttc acc tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gtg ccc ttc cac tgc agc ttc gct ccc agc cag aac ctc ttc aag       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gcc aat ccg ctg gtg gac cag tac ctg tac cgc ttt gtg agc acc       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac act tcc ggt aac cta cag ttc caa aag aac ttg aag gcc aga tat       1344
Asp Thr Ser Gly Asn Leu Gln Phe Gln Lys Asn Leu Lys Ala Arg Tyr           
        435                 440                 445                       

gcc aac acc tac aag aac tgg ttt ccg ggg ccc atg tgc cgg acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tat aca ggc tcg ggc aca tat aac aac aaa ggc gtt gcc aac       1440
Gly Trp Tyr Thr Gly Ser Gly Thr Tyr Asn Asn Lys Gly Val Ala Asn           
465                 470                 475                 480           

ttt ggt act tca aac aaa atg gac cta gag gga gcc agt tac caa gta       1488
Phe Gly Thr Ser Asn Lys Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

aac cct caa ccc aac gga atg aca aac acg ctt cag gat agt aac aga       1536
Asn Pro Gln Pro Asn Gly Met Thr Asn Thr Leu Gln Asp Ser Asn Arg           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg atc ttc aac gcc cag aac gcc cct ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Pro Pro           
        515                 520                 525                       

gga act acc tct ctg tac cag gag aac aat ctt ttg ata acc agc gag       1632
Gly Thr Thr Ser Leu Tyr Gln Glu Asn Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag acg cag cct gtg aac cgc ttg gcc tac cac acc ggt ggt cag       1680
Ser Glu Thr Gln Pro Val Asn Arg Leu Ala Tyr His Thr Gly Gly Gln           
545                 550                 555                 560           

gta tca aac aac aat cag aat tca act aca cct cct acg acc gga gta       1728
Val Ser Asn Asn Asn Gln Asn Ser Thr Thr Pro Pro Thr Thr Gly Val           
                565                 570                 575               

tac aat cat cag gaa gtg ttg cct ggt agc gtg tgg atg gac aga gac       1776
Tyr Asn His Gln Glu Val Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gta tac ctt cag ggt ccc atc tgg gcc aaa atc cca gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cat ttt cat cct tct ccg gct atg ggc gga ttc gga ctc aaa cac cca       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro           
    610                 615                 620                           

ccg cct atg atg ctc atc aag aac acg ccg gta cct agc aat gtc gct       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Ala           
625                 630                 635                 640           

gcc ttt tcg gat gtg ccc gtt aaa agc ttc atc acc cag tac agc acc       1968
Ala Phe Ser Asp Val Pro Val Lys Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

gga cag gtc acg gtg gag att gaa tgg gag ctc aag aag gaa aac tcc       2016
Gly Gln Val Thr Val Glu Ile Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag agg tgg aac ccc gag atc cag tac acc aac aac tac agc aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Ser Asn Pro           
        675                 680                 685                       

aca ttc gtg gac ttt gct cca gac acc tcc ggc gag tac agg acc acg       2112
Thr Phe Val Asp Phe Ala Pro Asp Thr Ser Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgt tac ctt acc cga cct ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  8
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  8

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Leu Glu 
225                 230                 235                 240 


Ile His Ser Gly Glu Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Thr Gln Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asp 
        355                 360                 365             


Asp Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Thr Ser Gly Asn Leu Gln Phe Gln Lys Asn Leu Lys Ala Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Ser Gly Thr Tyr Asn Asn Lys Gly Val Ala Asn 
465                 470                 475                 480 


Phe Gly Thr Ser Asn Lys Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Asn Pro Gln Pro Asn Gly Met Thr Asn Thr Leu Gln Asp Ser Asn Arg 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Pro Pro 
        515                 520                 525             


Gly Thr Thr Ser Leu Tyr Gln Glu Asn Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Leu Ala Tyr His Thr Gly Gly Gln 
545                 550                 555                 560 


Val Ser Asn Asn Asn Gln Asn Ser Thr Thr Pro Pro Thr Thr Gly Val 
                565                 570                 575     


Tyr Asn His Gln Glu Val Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Ala 
625                 630                 635                 640 


Ala Phe Ser Asp Val Pro Val Lys Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Ile Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Ser Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Thr Ser Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  9
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  9
atg tcg ttt gtt gat cac ccc cca gat tgg ctt gag gag atc ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ctg gga ccc gga aac ggt ctc gac cgc gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gca gac gag gtc gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt caa gag aag ctc gcg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtg gag gag cct gtt aag acg gct gct aaa gga gag cgg ata        432
Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat ccc aag aag aag aag gct cgg atc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ttg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggc aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cga acc tgg gtg ctg ccc agc tac aac aac cat cag tac ctt gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Leu Glu           
225                 230                 235                 240           

atc cac agc ggt tcc gtc gac gga agc aac gct aac gcc tac ttt gga        768
Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc ccc cga gac tgg cag cga ctc gtc aac aac tac tgg gga ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc agg tct ctc aag gtc aag atc ttc aac atc caa gtc aag gaa        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc aca acg cag gac ggc acc acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Thr Gln Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc caa gtg ttt acg gac gat gac tac cag ctg ccc tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acg gag ggg tgc ctg ccg gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tat ggc tac gcg acg ctg aac cgt aac aac acc gac       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asp           
        355                 360                 365                       

gat ccc acc gag cgg agc agt ttc ttc tgc ctg gaa tac ttt ccc agc       1152
Asp Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg ctg cgg acg ggc aac aac ttt gaa ttc acc tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gtg ccc ttc cac tgc agc ttc gct ccc agc cag aac ctc ttc aag       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gcc aat ccg ctg gtg gac cag tac ctg tac cgc ttc gtg agc act       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac acc tcg ggc aat att cag ttc caa aag aac ttg aag gcc aga tat       1344
Asp Thr Ser Gly Asn Ile Gln Phe Gln Lys Asn Leu Lys Ala Arg Tyr           
        435                 440                 445                       

gcc aac act tac aag aat tgg ttt ccg ggg ccc atg tgc cgg acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tac acg agc gcg ggc aca tat aac aac aaa ggc gtt gcc aac       1440
Gly Trp Tyr Thr Ser Ala Gly Thr Tyr Asn Asn Lys Gly Val Ala Asn           
465                 470                 475                 480           

ttt gat act tca aac aag atg gaa ctg gag ggg gct agt tac caa gta       1488
Phe Asp Thr Ser Asn Lys Met Glu Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

aac cct caa cca aat gga atg aca aac acg ctc cag gat agt aac aaa       1536
Asn Pro Gln Pro Asn Gly Met Thr Asn Thr Leu Gln Asp Ser Asn Lys           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg atc ttc aac gca cag aac gcc cct ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Pro Pro           
        515                 520                 525                       

gga acg acc tct ctg tac cag gag aac aat ctt ttg ata acc agc gag       1632
Gly Thr Thr Ser Leu Tyr Gln Glu Asn Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gaa acg cag cct gtg aac cga ttg gcc tac aac acc ggt ggt cag       1680
Ser Glu Thr Gln Pro Val Asn Arg Leu Ala Tyr Asn Thr Gly Gly Gln           
545                 550                 555                 560           

gta tca aac aac aac cag aat tca aat aca cat cct acg gtc gga gta       1728
Val Ser Asn Asn Asn Gln Asn Ser Asn Thr His Pro Thr Val Gly Val           
                565                 570                 575               

tac aat cac cag gaa gtg ttg cct ggt agc gtg tgg atg gac aga gac       1776
Tyr Asn His Gln Glu Val Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gta tac ctt cag ggc ccc atc tgg gcc aaa atc ccg gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cac ttt cat cct tct ccg gct atg ggc gga ttt gga ctc aaa cac cca       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro           
    610                 615                 620                           

ccg ccc atg atg ctc atc aag aac aca ccg gta cct agc aac gtc gct       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Ala           
625                 630                 635                 640           

gcc ttt tct gac gtg ccc gtt aaa agc ttc atc acc cag tac agc acc       1968
Ala Phe Ser Asp Val Pro Val Lys Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

gga cag gtc acg gtg gag att gaa tgg gag ctc aag aaa gaa aac tcc       2016
Gly Gln Val Thr Val Glu Ile Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag aga tgg aac ccc gag atc cag tac acc aac aac tac aac aac cca       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro           
        675                 680                 685                       

gag ttc gtg gac ttt gct cca gac acg tcc ggc gag tac aga acc acg       2112
Glu Phe Val Asp Phe Ala Pro Asp Thr Ser Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgc tac ctt acc cgg cct ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  10
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  10

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Gln Tyr Leu Glu 
225                 230                 235                 240 


Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Val Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Thr Gln Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asp Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asp 
        355                 360                 365             


Asp Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Thr Ser Gly Asn Ile Gln Phe Gln Lys Asn Leu Lys Ala Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Ser Ala Gly Thr Tyr Asn Asn Lys Gly Val Ala Asn 
465                 470                 475                 480 


Phe Asp Thr Ser Asn Lys Met Glu Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Asn Pro Gln Pro Asn Gly Met Thr Asn Thr Leu Gln Asp Ser Asn Lys 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Pro Pro 
        515                 520                 525             


Gly Thr Thr Ser Leu Tyr Gln Glu Asn Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Leu Ala Tyr Asn Thr Gly Gly Gln 
545                 550                 555                 560 


Val Ser Asn Asn Asn Gln Asn Ser Asn Thr His Pro Thr Val Gly Val 
                565                 570                 575     


Tyr Asn His Gln Glu Val Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Ala 
625                 630                 635                 640 


Ala Phe Ser Asp Val Pro Val Lys Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Ile Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro 
        675                 680                 685             


Glu Phe Val Asp Phe Ala Pro Asp Thr Ser Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  11
<211>  2187
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2187)

<400>  11
atg tcg ttt gtt gat cac cct cca gat tgg ctt gag gag atc ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tat ctg gga ccc ttc aac gga ctc gac aag gga gat ccc gtc        192
Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val           
    50                  55                  60                            

aac cga gcg gac gct gtt gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc aag gac gac acc tcc ttt ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gca cct gtt aag acg gct cca gcc aag aag cgg ccg        432
Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro           
    130                 135                 140                           

ata gag aag tct ccg gcg gaa ccg agc tct tcg aag ggc atc ggc aag        480
Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys           
145                 150                 155                 160           

gcg ggc cag cag cct gcg aga aag cga ctc aac ttt ggt cag act gga        528
Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly           
                165                 170                 175               

gac gca gac tcc gcc cct gac ccc cag cct ctc gga gaa cca ccc gca        576
Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala           
            180                 185                 190                   

gcc ccc tct ggt ctg gga act ggt acg atg gct tca ggc ggt ggc gca        624
Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala           
        195                 200                 205                       

cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc tcg        672
Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser           
    210                 215                 220                           

gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac cga gtc atc acc        720
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr           
225                 230                 235                 240           

acc agc acc cgc acc tgg gcc ctg ccc acc tac aac aat cat ctc tac        768
Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr           
                245                 250                 255               

aaa caa atc tcc agc agt tcc gga tcg ggt gct acc aac gac aac cac        816
Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tcg ccg cga gac tgg cag cga ctc atc aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg ggg ttc cgg ccc aag cga ctc aac ttc aag ctg ttc aac atc caa        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gaa gtt acg gaa acg gac ggc acg aag acc atc gcc aat aac       1008
Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt cag gtc ttt gcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tat gtc ctc ggc tcg gca cac cag ggc tgc ttc ccg ccg ttc ccg gca       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gtc ttc atg atc ccg cag tat ggg tac cta acc ctg aac aac ggg       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agt cat gca atg gga cgt tcg tcc ttc tac tgc ttg gag tac ttc ccg       1200
Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tcg cag atg ctg cgg acg gga aac aac ttc acg ttc agc tac acc ttc       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gaa gac gtg ccc ttc cac agc agc tac gcg cac agc caa agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

cga ctg atg aac ccg ctc atc gac cag tac ctg tac tac cta agt aag       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys           
        435                 440                 445                       

aca aat ggc ggt cta aga ttt tct caa gcg ggg ccc tcg agc atg cgc       1392
Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg           
    450                 455                 460                           

gat cag tcc agg aat tgg ctg ccg gga cca tgc ttc cgt caa cag cgg       1440
Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg           
465                 470                 475                 480           

att tca acc gta cct aca caa aat aac aac gga gaa ttt tcg tgg acg       1488
Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr           
                485                 490                 495               

gga gcc aca aag tat cat ctc aat ggt aga aac tcg gcg atg aac ccg       1536
Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro           
            500                 505                 510                   

ggc ccg gcc atg gct agc cat aag gac gac gag cac agg ttc ttc cct       1584
Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro           
        515                 520                 525                       

cag aac ggc gtg ctc atc ttt gga aaa cag ggc gca gac aag aca aat       1632
Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn           
    530                 535                 540                           

gcg ata ctc gaa aaa gtg atc atc act gac gaa gag gag atc agg acc       1680
Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr           
545                 550                 555                 560           

aca aac cct gta gcc acg gag gag tac ggg ttt gtc gcc act agt cta       1728
Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu           
                565                 570                 575               

caa agc tcg acc gaa gca gcc gag acc gca aga gtc aac gcg caa ggc       1776
Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly           
            580                 585                 590                   

atc ctc cct ggc atg gtg tgg cag gat cga gat gtg tat ctg cag gga       1824
Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly           
        595                 600                 605                       

ccc atc tgg gct aag att ccc cac acg gac gga cac ttc cac ccc tcg       1872
Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser           
    610                 615                 620                           

ccg ctc atg ggc gga ttc ggc ctt aag cat cca ccc cca caa atc ctc       1920
Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu           
625                 630                 635                 640           

atc aag aat acg ccg gtg cca tcg gac cct cca ttg acc ttc aac ccg       1968
Ile Lys Asn Thr Pro Val Pro Ser Asp Pro Pro Leu Thr Phe Asn Pro           
                645                 650                 655               

gcg aag cta gcg tcc ttc atc acg cag tac tcc acg ggc cag gtc agc       2016
Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser           
            660                 665                 670                   

gtg gaa atc gag tgg gag ctg cag aag gaa aac agc aag cgc tgg aac       2064
Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn           
        675                 680                 685                       

ccc gag gtc cag tac acg tcc aac tac gac aag tcc gtc aac gtg gac       2112
Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asp Lys Ser Val Asn Val Asp           
    690                 695                 700                           

ttc aca gta aac ggg gat ggc gtg tac tcg gaa ccg cga acc atc gga       2160
Phe Thr Val Asn Gly Asp Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly           
705                 710                 715                 720           

agc cgc tac ctt acc cgt aac ctg taa                                   2187
Ser Arg Tyr Leu Thr Arg Asn Leu                                           
                725                                                       


<210>  12
<211>  728
<212>  PRT
<213>  adeno-associated virus

<400>  12

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro 
    130                 135                 140                 


Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys 
145                 150                 155                 160 


Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg 
    450                 455                 460                 


Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg 
465                 470                 475                 480 


Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr 
                485                 490                 495     


Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro 
            500                 505                 510         


Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro 
        515                 520                 525             


Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn 
    530                 535                 540                 


Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu 
                565                 570                 575     


Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly 
            580                 585                 590         


Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ser Asp Pro Pro Leu Thr Phe Asn Pro 
                645                 650                 655     


Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asp Lys Ser Val Asn Val Asp 
    690                 695                 700                 


Phe Thr Val Asn Gly Asp Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly 
705                 710                 715                 720 


Ser Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  13
<211>  2187
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2187)

<220>
<221>  misc_feature
<222>  (499)..(502)
<223>  n is a, c, g, or t

<400>  13
atg tcg ttt gtt gat cac ccc cca gat tgg ttg gaa gag gtt ggt gaa         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu           
1               5                   10                  15                

ggc ctt cac gag ttt ttg gag ctc gaa gct ggc cca ccc aaa ccg aag         96
Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag cag gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tat ctg gga ccc ttc aac gga ctc gac aag gga gat ccc gtc        192
Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val           
    50                  55                  60                            

aac cga gcg gac gct gtt gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc aag gac gac acc tcc ttt ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca atc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gca cct gtt aag acg gct cca gcc aag aag cgg ccg        432
Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro           
    130                 135                 140                           

ata gag aag tct ccg gcg gaa ccg agc tct tcg aag ggc atc ggc aag        480
Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys           
145                 150                 155                 160           

gcg ggc cag cag cct gcg nnn nag cga ctc aac ttt ggt cag act gga        528
Ala Gly Gln Gln Pro Ala Xaa Xaa Arg Leu Asn Phe Gly Gln Thr Gly           
                165                 170                 175               

gac gca gac tcc gcc cct gac ccc cag cct ctc gga gaa cca ccc gca        576
Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala           
            180                 185                 190                   

gcc ccc tct ggt ctg gga act ggt acg atg gct tca ggc ggt ggc gca        624
Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala           
        195                 200                 205                       

cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc tcg        672
Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser           
    210                 215                 220                           

gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac cga gtc atc acc        720
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr           
225                 230                 235                 240           

acc agc acc cgc acc tgg gcc ctg ccc acc tac aac aat cat ctc tac        768
Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr           
                245                 250                 255               

aaa caa atc tcc agc agt tcc gga tcg ggt gct acc aac gac aac cac        816
Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tcg ccg cga gac tgg cag cga ctc atc aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg ggg ttc cgg ccc aag cga ctc aac ttc aag ctg ttc aac atc caa        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gaa gtt acg gaa acg gac ggc acg aag acc atc gcc aat aac       1008
Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt cag gtc ttt gcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tat gtc ctc ggc tcg gca cac cag ggc tgc ttc ccg ccg ttc ccg gca       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gtc ttc atg atc ccg cag tat ggg tac cta acc ctg aac aac ggg       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agt cat gca atg gga cgt tcg tcc ttc tac tgc ttg gag tac ttc ccg       1200
Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tcg cag atg ctg cgg acg gga aac aac ttc acg ttc agc tac acc ttc       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gaa gac gtg ccc ttc cac agc agc tac gcg cac agc caa agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

cga ctg atg aac ccg ctc atc gac cag tac ctg tac tac cta agt aag       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys           
        435                 440                 445                       

aca aat ggc ggt cta aga ttt tct caa gcg ggg ccc tcg agc atg cgc       1392
Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg           
    450                 455                 460                           

gat cag tcc agg aat tgg ctg ccg gga cca tgc ttc cgt caa cag cgg       1440
Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg           
465                 470                 475                 480           

att tca acc gta cct aca caa aat aac aac gga gaa ttt tcg tgg acg       1488
Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr           
                485                 490                 495               

gga gcc aca aag tat cat ctc aat ggt aga aac tcg gcg atg aac ccg       1536
Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro           
            500                 505                 510                   

ggc ccg gcc atg gct agc cat aag gac gac gag cac agg ttc ttc cct       1584
Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro           
        515                 520                 525                       

cag aac ggc gtg ctc atc ttt gga aaa cag ggc gca gac aag aca aat       1632
Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn           
    530                 535                 540                           

gcg ata ctc gaa aaa gtg atc atc act gac gaa gag gag atc agg acc       1680
Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr           
545                 550                 555                 560           

aca aac cct gta gcc acg gag gag tac ggg ttt gtc gcc act agt cta       1728
Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu           
                565                 570                 575               

caa agc tcg acc gaa gca gcc gag acc gca aga gtc aac gcg caa ggc       1776
Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly           
            580                 585                 590                   

atc ctc cct ggc atg gtg tgg cag gat cga gat gtg tat ctg cag gga       1824
Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly           
        595                 600                 605                       

ccc atc tgg gct aag att ccc cac acg gac gga cac ttc cac ccc tcg       1872
Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser           
    610                 615                 620                           

ccg ctc atg ggc gga ttc ggc ctt aag cat cca ccc cca caa atc ctc       1920
Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu           
625                 630                 635                 640           

atc aag aat acg ccg gtg cca tcg gac cct cca ttg acc ttc aac ccg       1968
Ile Lys Asn Thr Pro Val Pro Ser Asp Pro Pro Leu Thr Phe Asn Pro           
                645                 650                 655               

gcg aag cta gcg tcc ttc atc acg cag tac tcc acg ggc cag gtc agc       2016
Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser           
            660                 665                 670                   

gtg gaa atc gag tgg gag ctg cag aag gaa aac agc aag cgc tgg aac       2064
Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn           
        675                 680                 685                       

ccc gag gtc cag tac acg tcc aac tac gac aag tcc gtc aac gtg gac       2112
Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asp Lys Ser Val Asn Val Asp           
    690                 695                 700                           

ttc aca gta aac ggg gat ggc gtg tac tcg gaa ccg cga acc atc gga       2160
Phe Thr Val Asn Gly Asp Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly           
705                 710                 715                 720           

agc cgc tac ctt acc cgt aac ctg taa                                   2187
Ser Arg Tyr Leu Thr Arg Asn Leu                                           
                725                                                       


<210>  14
<211>  728
<212>  PRT
<213>  adeno-associated virus

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  The 'Xaa' at location 167 stands for Lys, Asn, Arg, Ser, Thr, 
       Ile, Met, Glu, Asp, Gly, Ala, Val, Gln, His, Pro, Leu, Tyr, Trp, 
       Cys, or Phe.

<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  The 'Xaa' at location 168 stands for Lys, Glu, or Gln.

<400>  14

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro 
    130                 135                 140                 


Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys 
145                 150                 155                 160 


Ala Gly Gln Gln Pro Ala Xaa Xaa Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg 
    450                 455                 460                 


Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg 
465                 470                 475                 480 


Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr 
                485                 490                 495     


Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro 
            500                 505                 510         


Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro 
        515                 520                 525             


Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn 
    530                 535                 540                 


Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu 
                565                 570                 575     


Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly 
            580                 585                 590         


Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ser Asp Pro Pro Leu Thr Phe Asn Pro 
                645                 650                 655     


Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asp Lys Ser Val Asn Val Asp 
    690                 695                 700                 


Phe Thr Val Asn Gly Asp Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly 
705                 710                 715                 720 


Ser Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  15
<211>  2187
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2187)

<220>
<221>  misc_feature
<222>  (1583)..(1583)
<223>  n is a, c, g, or t

<400>  15
atg tcg ttt gtt gat cac ccc cca gat tgg ttg gaa gag gtt ggt gaa         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu           
1               5                   10                  15                

ggc ctt cac gag ttt ttg gag ctc gaa gct ggc cca ccc aaa ccg aag         96
Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag cag gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tat ctg gga ccc ttc aac gga ctc gac aag gga gat ccc gtc        192
Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val           
    50                  55                  60                            

aac cga gcg gac gct gtt gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc aag gac gac acc tcc ttt ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca atc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gca cct gtt aag acg gct cca gcc aag aag cgg ccg        432
Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro           
    130                 135                 140                           

ata gag aag tct ccg gcg gaa ccg agc tct tcg aag ggc atc ggc aag        480
Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys           
145                 150                 155                 160           

gcg ggc cag cag cct gcg aga aag cga ctc aac ttt ggt cag act gga        528
Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly           
                165                 170                 175               

gac gca gac tcc gcc cct gac ccc cag cct ctc gga gaa cca ccc gca        576
Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala           
            180                 185                 190                   

gcc ccc tct ggt ctg gga act ggt acg atg gct tca ggc ggt ggc gca        624
Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala           
        195                 200                 205                       

cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc tcg        672
Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser           
    210                 215                 220                           

gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac cga gtc atc acc        720
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr           
225                 230                 235                 240           

acc agc acc cgc acc tgg gcc ctg ccc acc tac aac aat cat ctc tac        768
Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr           
                245                 250                 255               

aaa caa atc tcc agc agt tcc gga tcg ggt gct acc aac gac aac cac        816
Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tcg ccg cga gac tgg cag cga ctc atc aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg ggg ttc cgg ccc aag cga ctc aac ttc aag ctg ttc aac atc caa        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gaa gtt acg gaa acg gac ggc acg aag acc atc gcc aat aac       1008
Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt cag gtc ttt gcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tat gtc ctc ggc tcg gca cac cag ggc tgc ttc ccg ccg ttc ccg gca       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gtc ttc atg atc ccg cag tat ggg tac cta acc ctg aac aac ggg       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agt cat gca atg gga cgt tcg tcc ttc tac tgc ttg gag tac ttc ccg       1200
Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tcg cag atg ctg cgg acg gga aac aac ttc acg ttc agc tac acc ttc       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gaa gac gtg ccc ttc cac agc agc tac gcg cac agc caa agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

cga ctg atg aac ccg ctc atc gac cag tac ctg tac tac cta agt aag       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys           
        435                 440                 445                       

aca aat ggc ggt cta aga ttt tct caa gcg ggg ccc tcg agc atg cgc       1392
Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg           
    450                 455                 460                           

gat cag tcc agg aat tgg ctg ccg gga cca tgc ttc cgt caa cag cgg       1440
Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg           
465                 470                 475                 480           

att tca acc gta cct aca caa aat aac aac gga gaa ttt tcg tgg acg       1488
Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr           
                485                 490                 495               

gga gcc aca aag tat cat ctc aat ggt aga aac tcg gcg atg aac ccg       1536
Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro           
            500                 505                 510                   

ggc ccg gcc atg gct agc cat aag gac gac gag cac agg ttc ttc cnt       1584
Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Xaa           
        515                 520                 525                       

cag aac ggc gtg ctc atc ttt gga aaa cag ggc gca gac aag aca aat       1632
Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn           
    530                 535                 540                           

gcg ata ctc gaa aaa gtg atc atc act gac gaa gag gag atc agg acc       1680
Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr           
545                 550                 555                 560           

aca aac cct gta gcc acg gag gag tac ggg ttt gtc gcc act agt cta       1728
Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu           
                565                 570                 575               

caa agc tcg acc gaa gca gcc gag acc gca aga gtc aac gcg caa ggc       1776
Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly           
            580                 585                 590                   

atc ctc cct ggc atg gtg tgg cag gat cga gat gtg tat ctg cag gga       1824
Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly           
        595                 600                 605                       

ccc atc tgg gct aag att ccc cac acg gac gga cac ttc cac ccc tcg       1872
Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser           
    610                 615                 620                           

ccg ctc atg ggc gga ttc ggc ctt aag cat cca ccc cca caa atc ctc       1920
Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu           
625                 630                 635                 640           

atc aag aat acg ccg gtg cca tcg gac cct cca ttg acc ttc aac ccg       1968
Ile Lys Asn Thr Pro Val Pro Ser Asp Pro Pro Leu Thr Phe Asn Pro           
                645                 650                 655               

gcg aag cta gcg tcc ttc atc acg cag tac tcc acg ggc cag gtc agc       2016
Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser           
            660                 665                 670                   

gtg gaa atc gag tgg gag ctg cag aag gaa aac agc aag cgc tgg aac       2064
Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn           
        675                 680                 685                       

ccc gag gtc cag tac acg tcc aac tac gac aag tcc gtc aac gtg gac       2112
Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asp Lys Ser Val Asn Val Asp           
    690                 695                 700                           

ttc aca gta aac ggg gat ggc gtg tac tcg gaa ccg cga acc atc gga       2160
Phe Thr Val Asn Gly Asp Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly           
705                 710                 715                 720           

agc cgc tac ctt acc cgt aac ctg taa                                   2187
Ser Arg Tyr Leu Thr Arg Asn Leu                                           
                725                                                       


<210>  16
<211>  728
<212>  PRT
<213>  adeno-associated virus

<220>
<221>  misc_feature
<222>  (528)..(528)
<223>  The 'Xaa' at location 528 stands for His, Arg, Pro, or Leu.

<400>  16

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro 
    130                 135                 140                 


Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys 
145                 150                 155                 160 


Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg 
    450                 455                 460                 


Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg 
465                 470                 475                 480 


Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr 
                485                 490                 495     


Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro 
            500                 505                 510         


Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Xaa 
        515                 520                 525             


Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn 
    530                 535                 540                 


Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu 
                565                 570                 575     


Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly 
            580                 585                 590         


Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ser Asp Pro Pro Leu Thr Phe Asn Pro 
                645                 650                 655     


Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asp Lys Ser Val Asn Val Asp 
    690                 695                 700                 


Phe Thr Val Asn Gly Asp Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly 
705                 710                 715                 720 


Ser Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  17
<211>  2187
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2187)

<400>  17
atg tcg ttt gtt gat cac cct cca gat tgg ttg gaa gag gtt ggt gaa         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu           
1               5                   10                  15                

ggc ctt cac gag ttt ttg gag ctc gaa gct ggc cca ccc aaa ccg aag         96
Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag cag gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tat ctg gga ccc ttc aac gga ctc gac aag gga gat ccc gtc        192
Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val           
    50                  55                  60                            

aac cga gcg gac gct gtt gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc aag gac gac acc tcc ttt ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca atc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gca cct gtt aag acg gct cca gcc aag aag cgg ccg        432
Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro           
    130                 135                 140                           

ata gag aag tct ccg gcg gaa ccg agc tct tcg aag ggc atc ggc aag        480
Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys           
145                 150                 155                 160           

gcg ggc cag cag cct gcg aga aag cga ctc aac ttt ggt cag act gga        528
Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly           
                165                 170                 175               

gac gca gac tcc gcc cct gac ccc cag cct ctc gga gaa cca ccc gca        576
Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala           
            180                 185                 190                   

gcc ccc tct ggt ctg gga act ggt acg atg gct tca ggc ggt ggc gca        624
Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala           
        195                 200                 205                       

cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc tcg        672
Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser           
    210                 215                 220                           

gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac cga gtc atc acc        720
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr           
225                 230                 235                 240           

acc agc acc cgc acc tgg gcc ctg ccc acc tac aac aat cat ctc tac        768
Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr           
                245                 250                 255               

aaa caa atc tcc agc agt tcc gga tcg ggt gct acc aac gac aac cac        816
Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tcg ccg cga gac tgg cag cga ctc atc aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg ggg ttc cgg ccc aag cga ctc aac ttc aag ctg ttc aac atc caa        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gaa gtt acg gaa acg gac ggc acg aag acc atc gcc aat aac       1008
Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt cag gtc ttt gcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tat gtc ctc ggc tcg gca cac cag ggc tgc ttc ccg ccg ttc ccg gca       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gtc ttc atg atc ccg cag tat ggg tac cta acc ctg aac aac ggg       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agt cat gca atg gga cgt tcg tcc ttc tac tgc ttg gag tac ttc ccg       1200
Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tcg cag atg ctg cgg acg gga aac aac ttc acg ttc agc tac acc ttc       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gaa gac gtg ccc ttc cac agc agc tac gcg cac agc caa agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

cga ctg atg aac ccg ctc atc gac cag tac ctg tac tac cta agt aag       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys           
        435                 440                 445                       

aca aat ggc ggt cta aga ttt tct caa gcg ggg ccc tcg agc atg cgc       1392
Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg           
    450                 455                 460                           

gat cag tcc agg aat tgg ctg ccg gga cca tgc ttc cgt caa cag cgg       1440
Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg           
465                 470                 475                 480           

att tca acc gta cct aca caa aat aac aac gga gaa ttt tcg tgg acg       1488
Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr           
                485                 490                 495               

gga gcc aca aag tat cat ctc aat ggt aga aac tcg gcg atg aac ccg       1536
Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro           
            500                 505                 510                   

ggc ccg gcc atg gct agc cat aag gac gac gag cac agg ttc ttc cct       1584
Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro           
        515                 520                 525                       

cag aac ggc gtg ctc atc ttt gga aaa cag ggc gca gac aag aca aat       1632
Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn           
    530                 535                 540                           

gcg ata ctc gaa aaa gtg atc atc act gac gaa gag gag atc agg acc       1680
Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr           
545                 550                 555                 560           

aca aac cct gta gcc acg gag gag tac ggg ttt gtc gcc act agt cta       1728
Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu           
                565                 570                 575               

caa agc tcg acc gaa gca gcc gag acc gca aga gtc aac gcg caa ggc       1776
Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly           
            580                 585                 590                   

atc ctc cct ggc atg gtg tgg cag gat cga gat gtg tat ctg cag gga       1824
Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly           
        595                 600                 605                       

ccc atc tgg gct aag att ccc cac acg gac gga cac ttc cac ccc tcg       1872
Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser           
    610                 615                 620                           

ccg ctc atg ggc gga ttc ggc ctt aag cat cca ccc cca caa atc ctc       1920
Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu           
625                 630                 635                 640           

atc aag aat acg ccg gtg cca tcg gac cct cca ttg acc ttc aac ccg       1968
Ile Lys Asn Thr Pro Val Pro Ser Asp Pro Pro Leu Thr Phe Asn Pro           
                645                 650                 655               

gcg aag cta gcg tcc ttc atc acg cag tac tcc acg ggc cag gtc agc       2016
Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser           
            660                 665                 670                   

gtg gaa atc gag tgg gag ctg cag aag gaa aac agc aag cgc tgg aac       2064
Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn           
        675                 680                 685                       

ccc gag gtc cag tac acg tcc aac tac gac aag tcc gtc aac gtg gac       2112
Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asp Lys Ser Val Asn Val Asp           
    690                 695                 700                           

ttc aca gta aac ggg gat ggc gtg tac tcg gaa ccg cga acc atc gga       2160
Phe Thr Val Asn Gly Asp Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly           
705                 710                 715                 720           

agc cgc tac ctt acc cgt aac ctg taa                                   2187
Ser Arg Tyr Leu Thr Arg Asn Leu                                           
                725                                                       


<210>  18
<211>  728
<212>  PRT
<213>  adeno-associated virus

<400>  18

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro 
    130                 135                 140                 


Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys 
145                 150                 155                 160 


Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg 
    450                 455                 460                 


Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg 
465                 470                 475                 480 


Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr 
                485                 490                 495     


Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro 
            500                 505                 510         


Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro 
        515                 520                 525             


Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn 
    530                 535                 540                 


Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu 
                565                 570                 575     


Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly 
            580                 585                 590         


Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ser Asp Pro Pro Leu Thr Phe Asn Pro 
                645                 650                 655     


Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asp Lys Ser Val Asn Val Asp 
    690                 695                 700                 


Phe Thr Val Asn Gly Asp Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly 
705                 710                 715                 720 


Ser Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  19
<211>  2187
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2187)

<400>  19
atg tcg ttt gtt gat cac cct cca gat tgg ttg gaa gag gtt ggt gaa         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu           
1               5                   10                  15                

ggc ctt cac gag ttt ttg gag ctc gaa gct ggc cca ccc aaa ccg aag         96
Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag cag gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tat ctg gga ccc ttc aac gga ctc gac aag gga gat ccc gtc        192
Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val           
    50                  55                  60                            

aac cga gcg gac gct gtt gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc aag gac gac acc tcc ttt ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca atc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gca cct gtt aag acg gct cca gcc aag aag cgg ccg        432
Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro           
    130                 135                 140                           

ata gag aag tct ccg gcg gaa ccg agc tct tcg aag ggc atc ggc aag        480
Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys           
145                 150                 155                 160           

gcg ggc cag cag cct gcg aga aag cga ctc aac ttt ggt cag act gga        528
Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly           
                165                 170                 175               

gac gca gac tcc gcc cct gac ccc cag cct ctc gga gaa cca ccc gca        576
Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala           
            180                 185                 190                   

gcc ccc tct ggt ctg gga act ggt acg atg gct tca ggc ggt ggc gca        624
Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala           
        195                 200                 205                       

cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc tcg        672
Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser           
    210                 215                 220                           

gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac cga gtc atc acc        720
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr           
225                 230                 235                 240           

acc agc acc cgc acc tgg gcc ctg ccc acc tac aac aat cat ctc tac        768
Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr           
                245                 250                 255               

aaa caa atc tcc agc agt tcc gga tcg ggt gct acc aac gac aac cac        816
Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tcg ccg cga gac tgg cag cga ctc atc aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg ggg ttc cgg ccc aag cga ctc aac ttc aag ctg ttc aac atc caa        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gaa gtt acg gaa acg gac ggc acg aag acc atc gcc aat aac       1008
Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt cag gtc ttt gcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tat gtc ctc ggc tcg gca cac cag ggc tgc ttc ccg ccg ttc ccg gca       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gtc ttc atg atc ccg cag tat ggg tac cta acc ctg aac aac ggg       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agt cat gca atg gga cgt tcg tcc ttc tac tgc ttg gag tac ttc ccg       1200
Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tcg cag atg ctg cgg acg gga aac aac ttc acg ttc agc tac acc ttc       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gaa gac gtg ccc ttc cac agc agc tac gcg cac agc caa agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

cga ctg atg aac ccg ctc atc gac cag tac ctg tac tac cta agt aag       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys           
        435                 440                 445                       

aca aat ggc ggt cta aga ttt tct caa gcg ggg ccc tcg agc atg cgc       1392
Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg           
    450                 455                 460                           

gat cag tcc agg aat tgg ctg ccg gga cca tgc ttc cgt caa cag cgg       1440
Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg           
465                 470                 475                 480           

att tca acc gta cct aca caa aat aac aac gga gaa ttt tcg tgg acg       1488
Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr           
                485                 490                 495               

gga gcc aca aag tat cat ctc aat ggt aga aac tcg gcg atg aac ccg       1536
Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro           
            500                 505                 510                   

ggc ccg gcc atg gct agc cat aag gac gac gag cac agg ttc ttc cct       1584
Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro           
        515                 520                 525                       

cag aac ggc gtg ctc atc ttt gga aaa cag ggc gca gac aag aca aat       1632
Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn           
    530                 535                 540                           

gcg ata ctc gaa aaa gtg atc atc act gac gaa gag gag atc agg acc       1680
Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr           
545                 550                 555                 560           

aca aac cct gta gcc acg gag gag tac ggg ttt gtc gcc act agt cta       1728
Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu           
                565                 570                 575               

caa agc tcg acc gaa gca gcc gag acc gca aga gtc aac gcg caa ggc       1776
Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly           
            580                 585                 590                   

atc ctc cct ggc atg gtg tgg cag gat cga gat gtg tat ctg cag gga       1824
Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly           
        595                 600                 605                       

ccc atc tgg gct aag att ccc cac acg gac gga cac ttc cac ccc tcg       1872
Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser           
    610                 615                 620                           

ccg ctc atg ggc gga ttc ggc ctt aag cat cca ccc cca caa atc ctc       1920
Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu           
625                 630                 635                 640           

atc aag aat acg ccg gtg cca tcg gac cct cca ttg acc ttc aac ccg       1968
Ile Lys Asn Thr Pro Val Pro Ser Asp Pro Pro Leu Thr Phe Asn Pro           
                645                 650                 655               

gcg aag cta gcg tcc ttc atc acg cag tac tcc acg ggc cag gtc agc       2016
Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser           
            660                 665                 670                   

gtg gaa atc gag tgg gag ctg cag aag gaa aac agc aag cgc tgg aac       2064
Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn           
        675                 680                 685                       

ccc gag gtc cag tac acg tcc aac tac gac aag tcc gtc aac gtg gac       2112
Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asp Lys Ser Val Asn Val Asp           
    690                 695                 700                           

ttc aca gta aac ggg gat ggc gtg tac tcg gaa ccg cga acc atc gga       2160
Phe Thr Val Asn Gly Asp Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly           
705                 710                 715                 720           

acc cgc tac ctt acc cgt aac ctg taa                                   2187
Thr Arg Tyr Leu Thr Arg Asn Leu                                           
                725                                                       


<210>  20
<211>  728
<212>  PRT
<213>  adeno-associated virus

<400>  20

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro 
    130                 135                 140                 


Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys 
145                 150                 155                 160 


Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg 
    450                 455                 460                 


Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg 
465                 470                 475                 480 


Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr 
                485                 490                 495     


Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro 
            500                 505                 510         


Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro 
        515                 520                 525             


Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn 
    530                 535                 540                 


Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu 
                565                 570                 575     


Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly 
            580                 585                 590         


Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ser Asp Pro Pro Leu Thr Phe Asn Pro 
                645                 650                 655     


Ala Lys Leu Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asp Lys Ser Val Asn Val Asp 
    690                 695                 700                 


Phe Thr Val Asn Gly Asp Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  21
<211>  2187
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2187)

<400>  21
atg tcg ttt gtt gat cac cct cca gat tgg ttg gaa gag gtt ggt gaa         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu           
1               5                   10                  15                

ggc ctt cac gag ttt ttg gag ctc gaa gct ggc cca ccc aaa ccg aag         96
Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag cag gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tat ctg gga ccc ttc aac gga ctc gac aag gga gat ccc gtc        192
Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val           
    50                  55                  60                            

aac cga gcg gac gct gtt gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc aag gac gac acc tcc ttt ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca atc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gca cct gtt aag acg gct cca gcc aag aag cgg ccg        432
Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro           
    130                 135                 140                           

ata gag aag tct ccg gcg gaa ccg agc tct tcg aag ggc atc ggc aag        480
Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys           
145                 150                 155                 160           

gcg ggc cag cag cct gcg aga aag cga ctc aac ttt ggt cag act gga        528
Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly           
                165                 170                 175               

gac gca gac tcc gcc cct gac ccc cag cct ctc gga gaa cca ccc gca        576
Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala           
            180                 185                 190                   

gcc ccc tct ggt ctg gga act ggt acg atg gct tca ggc ggt ggc gca        624
Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala           
        195                 200                 205                       

cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc tcg        672
Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser           
    210                 215                 220                           

gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac cga gtc atc acc        720
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr           
225                 230                 235                 240           

acc agc acc cgc acc tgg gcc ctg ccc acc tac aac aat cat ctc tac        768
Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr           
                245                 250                 255               

aaa caa atc tcc agc agt tcc gga tcg ggt gct acc aac gac aac cac        816
Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tcg ccg cga gac tgg cag cga ctc atc aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg ggg ttc cgg ccc aag cga ctc aac ttc aag ctg ttc aac atc caa        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gaa gtt acg gaa acg gac ggc acg aag acc atc gcc aat aac       1008
Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt cag gtc ttt gcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tat gtc ctc ggc tcg gca cac cag ggc tgc ttc ccg ccg ttc ccg gca       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gtc ttc atg atc ccg cag tat ggg tac cta acc ctg aac aac ggg       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agt cat gca atg gga cgt tcg tcc ttc tac tgc ttg gag tac ttc ccg       1200
Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tcg cag atg ctg cgg acg gga aac aac ttc acg ttc agc tac acc ttc       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gaa gac gtg ccc ttc cac agc agc tac gcg cac agc caa agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

cga ctg atg aac ccg ctc atc gac cag tac ctg tac tac cta agt aag       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys           
        435                 440                 445                       

aca aat ggc ggt cta aga ttt tct caa gcg ggg ccc tcg agc atg cgc       1392
Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg           
    450                 455                 460                           

gat cag tcc agg aat tgg ctg ccg gga cca tgc ttc cgt caa cag cgg       1440
Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg           
465                 470                 475                 480           

att tca acc gta cct aca caa aat aac aac gga gaa ttt tcg tgg acg       1488
Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr           
                485                 490                 495               

gga gcc aca aag tat cat ctc aat ggt aga aac tcg gcg atg aac ccg       1536
Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro           
            500                 505                 510                   

ggc ccg gcc atg gct agc cat aag gac gac gag cac agg ttc ttc cct       1584
Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro           
        515                 520                 525                       

cag aac ggc gtg ctc atc ttt gga aaa cag ggc gca gac aag aca aat       1632
Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn           
    530                 535                 540                           

gcg ata ctc gaa aaa gtg atc atc act gac gaa gag gag atc agg acc       1680
Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr           
545                 550                 555                 560           

aca aac cct gta gcc acg gag gag tac ggg ttt gtc gcc act agt cta       1728
Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu           
                565                 570                 575               

caa agc tcg acc gaa gca gcc gag acc gca aga gtc aac gcg caa ggc       1776
Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly           
            580                 585                 590                   

atc ctc cct ggc atg gtg tgg cag gat cga gat gtg tat ctg cag gga       1824
Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly           
        595                 600                 605                       

ccc atc tgg gct aag att ccc cac acg gac gga cac ttc cac ccc tcg       1872
Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser           
    610                 615                 620                           

ccg ctc atg ggc gga ttc ggc ctc aag cgc cca cct ccg cag atc ctc       1920
Pro Leu Met Gly Gly Phe Gly Leu Lys Arg Pro Pro Pro Gln Ile Leu           
625                 630                 635                 640           

atc aag aat act cct gtg ccg tcg aac cct cca gaa aca ttc aag cag       1968
Ile Lys Asn Thr Pro Val Pro Ser Asn Pro Pro Glu Thr Phe Lys Gln           
                645                 650                 655               

gac aag ctc aat gcc ttc atc acg cag tac tcc acg ggc cag gtc agc       2016
Asp Lys Leu Asn Ala Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser           
            660                 665                 670                   

gtg gag atc gag tgg gag ctg cag aag gag aac agc aag cgc tgg aac       2064
Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn           
        675                 680                 685                       

ccc gag gtc cag tac acc tcc aat tac aac aag tcc gtc aac gtg gac       2112
Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp           
    690                 695                 700                           

ttc acc gtg gac acc aac ggc gtg tac tcg gaa ccg cgc acc atc ggt       2160
Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly           
705                 710                 715                 720           

acc cgc tac ctc acc cgc aac ctg taa                                   2187
Thr Arg Tyr Leu Thr Arg Asn Leu                                           
                725                                                       


<210>  22
<211>  728
<212>  PRT
<213>  adeno-associated virus

<400>  22

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Asp Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro 
    130                 135                 140                 


Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys 
145                 150                 155                 160 


Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Ala Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Ser Ser Gly Ser Gly Ala Thr Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Asn Gly Gly Leu Arg Phe Ser Gln Ala Gly Pro Ser Ser Met Arg 
    450                 455                 460                 


Asp Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg 
465                 470                 475                 480 


Ile Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Glu Phe Ser Trp Thr 
                485                 490                 495     


Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro 
            500                 505                 510         


Gly Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro 
        515                 520                 525             


Gln Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Asp Lys Thr Asn 
    530                 535                 540                 


Ala Ile Leu Glu Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr 
545                 550                 555                 560 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu 
                565                 570                 575     


Gln Ser Ser Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly 
            580                 585                 590         


Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly 
        595                 600                 605             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser 
    610                 615                 620                 


Pro Leu Met Gly Gly Phe Gly Leu Lys Arg Pro Pro Pro Gln Ile Leu 
625                 630                 635                 640 


Ile Lys Asn Thr Pro Val Pro Ser Asn Pro Pro Glu Thr Phe Lys Gln 
                645                 650                 655     


Asp Lys Leu Asn Ala Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser 
            660                 665                 670         


Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn 
        675                 680                 685             


Pro Glu Val Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp 
    690                 695                 700                 


Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly 
705                 710                 715                 720 


Thr Arg Tyr Leu Thr Arg Asn Leu 
                725             


<210>  23
<211>  2184
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2184)

<400>  23
atg tcg ttt gtt gat cac ccc cca gat tgg ttg gaa gag gtt ggt gaa         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu           
1               5                   10                  15                

ggc ctt cac gag ttt ttg gag ctc gaa gct ggc cca ccc aaa ccg aag         96
Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag cag gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tat ctg gga ccc ttc aac gga ctc gac aag gga gag ccc gtc        192
Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro Val           
    50                  55                  60                            

aac cga gcg gac gcc gtt gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gat aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc aag gac gac acc tcc ttt ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca atc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gca cct gtt aag acg gct cca gcc aag aag cgg ccg        432
Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro           
    130                 135                 140                           

ata gag aag tct ccg gcg gaa ccg agc tct tcg aag ggc atc ggc aag        480
Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys           
145                 150                 155                 160           

gcg ggc cag cag cct gcg aga aag cga ctc aac ttt ggt cag act gga        528
Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly           
                165                 170                 175               

gac gcc gac tcc gcc gct gac ccc cag cct ctc gga gaa cca ccc gca        576
Asp Ala Asp Ser Ala Ala Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala           
            180                 185                 190                   

gcc ccc tct ggt ctg gga act ggt tcg atg gct tca ggc ggt ggc gca        624
Ala Pro Ser Gly Leu Gly Thr Gly Ser Met Ala Ser Gly Gly Gly Ala           
        195                 200                 205                       

cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc tcg        672
Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser           
    210                 215                 220                           

gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac cga gtc atc acc        720
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr           
225                 230                 235                 240           

acc agc acc cgc acc tgg gcc ctg ccc acc tac aac aac cac ctc tac        768
Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr           
                245                 250                 255               

aag caa atc tcc agt agt cag gcc gga gcc aac aac gac aac cac tac        816
Lys Gln Ile Ser Ser Ser Gln Ala Gly Ala Asn Asn Asp Asn His Tyr           
            260                 265                 270                   

ttt ggc tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc cac        864
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His           
        275                 280                 285                       

tgc cac ttc tcc cct cga gac tgg cag cgg ctc atc aac aac aac tgg        912
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp           
    290                 295                 300                           

ggg ttc cgg ccc aag cga ctc aac ttc aag ctg ttc aac atc caa gtc        960
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val           
305                 310                 315                 320           

aag gaa gtt act gaa acg gac ggc acc aag acc atc gcc aat aac ctt       1008
Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn Leu           
                325                 330                 335               

acc agc acg gtt cag gtc ttt gcg gac tcg gag tac cag ctc ccg tat       1056
Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro Tyr           
            340                 345                 350                   

gtc ctc gga tcg gcg cac cag ggt tgc ttc ccg ccg ttc ccg gcg gac       1104
Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala Asp           
        355                 360                 365                       

gtc ttc atg gtc ccg cag tac ggg tat ctg acg ctg aac aac ggc agc       1152
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser           
    370                 375                 380                           

cag gcg atg ggt cgt tcg tcc ttc tac tgt ctg gag tac ttt ccg tcg       1200
Gln Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser           
385                 390                 395                 400           

cag atg ctg cgg acg ggg aac aac ttt aca ttc agc tac acc ttc gag       1248
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu           
                405                 410                 415               

gac gtg ccc ttc cac agc agc tac gcg cac agc cag agt ctg gac cgg       1296
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg           
            420                 425                 430                   

ctc atg aac cca ctc atc gac cag tac ctg tac tac cta agc aag aca       1344
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr           
        435                 440                 445                       

aat ggc ggt cta gga ttt tcc caa gcg gga ccc aac agc atg cgc gac       1392
Asn Gly Gly Leu Gly Phe Ser Gln Ala Gly Pro Asn Ser Met Arg Asp           
    450                 455                 460                           

cag tcc agg aat tgg ctg ccg gga ccc tgc ttc aga caa caa cgg att       1440
Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Ile           
465                 470                 475                 480           

tca act gta cct aca caa aat aac aac gga gac ttt tcg tgg gcg gga       1488
Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Asp Phe Ser Trp Ala Gly           
                485                 490                 495               

gcc aca aag tat cat ctc aat ggt aga aac tcg gcg atg aac ccg ggc       1536
Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro Gly           
            500                 505                 510                   

ccg gcc atg gct agc cat aag gac gac gag cac agg ttc ttc cct cag       1584
Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro Gln           
        515                 520                 525                       

aac ggc gtg ctc atc ttt gga aaa cag ggc gca gaa aaa aac aat gcg       1632
Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Glu Lys Asn Asn Ala           
    530                 535                 540                           

ata ctc gac aag gta atc atc act gac gag gag gag atc agg act aca       1680
Ile Leu Asp Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr           
545                 550                 555                 560           

aac cct gta gcc acg gag gag tac ggg ttt gtc gcc act agt cta caa       1728
Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu Gln           
                565                 570                 575               

agc ccg acc gaa gca gcc gag acc gca aga gtc aac gcg caa ggc atc       1776
Ser Pro Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly Ile           
            580                 585                 590                   

ctc cct ggc atg gtg tgg cag gac cga gac gtg tat ctg cag ggg ccc       1824
Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro           
        595                 600                 605                       

atc tgg gcc aag atc ccc cac acg gat gga cac ttc cac ccc tcg cca       1872
Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro           
    610                 615                 620                           

ctc atg ggc ggg ttc ggc ctt aaa cat cca cct ccg cag atc ctc atc       1920
Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile           
625                 630                 635                 640           

aag aac act ccc gtg cct tcg aat cct cca gag aca ttc aac ccg gca       1968
Lys Asn Thr Pro Val Pro Ser Asn Pro Pro Glu Thr Phe Asn Pro Ala           
                645                 650                 655               

aag ctc aat gcc ttc atc acg cag tac tca acg gga cag gtc agc gtg       2016
Lys Leu Asn Ala Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val           
            660                 665                 670                   

gag atc gag tgg gag ctg cag aag gag aat agc aag cgc tgg aac ccc       2064
Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro           
        675                 680                 685                       

gag gtc cag tac acg tcc aac tac aac aag tcc gtc aac gtg gac ttt       2112
Glu Val Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe           
    690                 695                 700                           

aca gtg gac acc aac ggc gtg tac tcg gaa ccc cgc acc att gga acc       2160
Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly Thr           
705                 710                 715                 720           

cga tac ctt acc cgt aac ctg taa                                       2184
Arg Tyr Leu Thr Arg Asn Leu                                               
                725                                                       


<210>  24
<211>  727
<212>  PRT
<213>  adeno-associated virus

<400>  24

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro 
    130                 135                 140                 


Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys 
145                 150                 155                 160 


Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Ala Ala Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Gly Ser Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Ser Gln Ala Gly Ala Asn Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Asn Gly Gly Leu Gly Phe Ser Gln Ala Gly Pro Asn Ser Met Arg Asp 
    450                 455                 460                 


Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Ile 
465                 470                 475                 480 


Ser Thr Val Pro Thr Gln Asn Asn Asn Gly Asp Phe Ser Trp Ala Gly 
                485                 490                 495     


Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Asp Asp Glu His Arg Phe Phe Pro Gln 
        515                 520                 525             


Asn Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Glu Lys Asn Asn Ala 
    530                 535                 540                 


Ile Leu Asp Lys Val Ile Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Glu Tyr Gly Phe Val Ala Thr Ser Leu Gln 
                565                 570                 575     


Ser Pro Thr Glu Ala Ala Glu Thr Ala Arg Val Asn Ala Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ser Asn Pro Pro Glu Thr Phe Asn Pro Ala 
                645                 650                 655     


Lys Leu Asn Ala Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Val Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe 
    690                 695                 700                 


Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Thr Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  25
<211>  2184
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2184)

<400>  25
atg tcg ttt gtt gat cac ccc cca gat tgg ttg gaa gag gtt ggt gaa         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu           
1               5                   10                  15                

ggc ctt cac gag ttt ttg gag ctc gaa gct ggc cca ccc aaa ccg aag         96
Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag cag gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tat ctg gga ccc ttc aac gga atc gac aag gga gag ccc gtc        192
Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Ile Asp Lys Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gca gac gct gtc gcg aga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc aag gac gac acc tcc ttt ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gca cct gtt aag acg gct cca gcc aag aag cgg ccg        432
Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro           
    130                 135                 140                           

ata gag aag tct ccg gcg gaa ccg agc tct tcg aag ggc att ggc aag        480
Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys           
145                 150                 155                 160           

gcg ggc cag cag cct gcg aga aag cga ctc aac ttt ggt cag act gga        528
Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly           
                165                 170                 175               

gac gcc gac tcc gcc gct gac ccc cag cct ctc gga gaa cca ccc gca        576
Asp Ala Asp Ser Ala Ala Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala           
            180                 185                 190                   

gcc ccc tct ggt ctg gga act ggt acg atg gct tca ggc agt ggc gca        624
Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Ser Gly Ala           
        195                 200                 205                       

cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc tcg        672
Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser           
    210                 215                 220                           

gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac cga gtc atc acc        720
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr           
225                 230                 235                 240           

acc agc acc cgc acc tgg gcc ctg ccc acc tac aac aac cac ctc tac        768
Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr           
                245                 250                 255               

aag caa atc tcc tcc agc aat tac gga gcc aat aat gac aac cac tac        816
Lys Gln Ile Ser Ser Ser Asn Tyr Gly Ala Asn Asn Asp Asn His Tyr           
            260                 265                 270                   

ttt ggc tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc cat        864
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His           
        275                 280                 285                       

tgc cac ttc tct cca cga gac tgg cag cgg ctc atc aac aac aat tgg        912
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp           
    290                 295                 300                           

ggg ttc cgt ccc aag cgg ctc aac ttc aag ctg ttc aac atc caa gtc        960
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val           
305                 310                 315                 320           

aag gag gtc acg gaa aat gac ggc acc aag acc atc gcc aat aac ctt       1008
Lys Glu Val Thr Glu Asn Asp Gly Thr Lys Thr Ile Ala Asn Asn Leu           
                325                 330                 335               

acc agc acg gtt cag gtc ttt gcg gat tcg gag tac cag ttg ccg tac       1056
Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro Tyr           
            340                 345                 350                   

gtc ctt ggc tcg gcg cac cag ggc tgc ttc cca ccg ttt ccg gca gac       1104
Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala Asp           
        355                 360                 365                       

gtc ttc atg atc ccg cag tac ggg tac ctg acg cta aac aac ggc agt       1152
Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser           
    370                 375                 380                           

cat gcc atg ggc cgc tcg tcc ttc tac tgc ctg gag tac ttt ccg tcg       1200
His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser           
385                 390                 395                 400           

cag atg ctg cgg acg ggg aac aac ttc acg ttc agc tac acc ttc gag       1248
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu           
                405                 410                 415               

gac gtg ccc ttc cac agc agc tac gcg cac agc cag agc ctg gac cgg       1296
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg           
            420                 425                 430                   

ctc atg aat cct ctc atc gac cag tat ctg tac tac ttg agc aag acg       1344
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr           
        435                 440                 445                       

cag aac ggt ttg ggc ttt tct caa gcg gga ccc acc agc atg cgg aac       1392
Gln Asn Gly Leu Gly Phe Ser Gln Ala Gly Pro Thr Ser Met Arg Asn           
    450                 455                 460                           

cag tcc aga aac tgg ctc ccg gga ccc tgc ttc cgt cag cag cga gtt       1440
Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val           
465                 470                 475                 480           

tca gaa aga tcc aca gaa aac aac aac gga gac ttc tcg tgg acg gga       1488
Ser Glu Arg Ser Thr Glu Asn Asn Asn Gly Asp Phe Ser Trp Thr Gly           
                485                 490                 495               

gcc acc aag tat cac ctc aat gga aga aac tcg gcg atg aat cca ggc       1536
Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro Gly           
            500                 505                 510                   

ccg gcc atg gcc agt cac aag gac gac gag gac aga ttc ttt ccg caa       1584
Pro Ala Met Ala Ser His Lys Asp Asp Glu Asp Arg Phe Phe Pro Gln           
        515                 520                 525                       

aac ggc gtg ctc atc ttt gga aca ccg aac gct act gca agt aat aca       1632
Asn Gly Val Leu Ile Phe Gly Thr Pro Asn Ala Thr Ala Ser Asn Thr           
    530                 535                 540                           

cct cta gag aat gta ctg atc act gat gag gag gaa atc aga act acg       1680
Pro Leu Glu Asn Val Leu Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr           
545                 550                 555                 560           

aac cct gtg gcc aca gaa gag tac ggg atc gtt gct aac aat aaa cag       1728
Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asn Asn Lys Gln           
                565                 570                 575               

gac ggc agt aca cag gcg acg aca gcg att gtc aac gca caa ggc atc       1776
Asp Gly Ser Thr Gln Ala Thr Thr Ala Ile Val Asn Ala Gln Gly Ile           
            580                 585                 590                   

ctg ccc ggc atg gtg tgg cag gat cga gat gtg tac ctg cag ggg ccc       1824
Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro           
        595                 600                 605                       

atc tgg gcc aag ata ccc cac acg gat gga cac ttc cac cca tcg ccg       1872
Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro           
    610                 615                 620                           

ctc atg ggc gga ttc ggc ctt aag cat cca cct ccg cag atc ctc atc       1920
Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile           
625                 630                 635                 640           

aag aac acg cct gtg cca tca aac cct cca gaa aag ttc acc cag gaa       1968
Lys Asn Thr Pro Val Pro Ser Asn Pro Pro Glu Lys Phe Thr Gln Glu           
                645                 650                 655               

aaa ctc aat tcc ttc atc aca caa tac tcc acg gga cag gtc agt gtg       2016
Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val           
            660                 665                 670                   

gag atc gag tgg gag ctg cag aag gag aac agc aag cgc tgg aac ccc       2064
Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro           
        675                 680                 685                       

gag gtc caa tac act tcc aac tac aac aag tcc gtc aac gtg gac ttc       2112
Glu Val Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe           
    690                 695                 700                           

acc gtg gac acc aac ggc atg tat tcg gaa ccg cga acc atc gga acc       2160
Thr Val Asp Thr Asn Gly Met Tyr Ser Glu Pro Arg Thr Ile Gly Thr           
705                 710                 715                 720           

cga tac ctt acc cgc aac ctg taa                                       2184
Arg Tyr Leu Thr Arg Asn Leu                                               
                725                                                       


<210>  26
<211>  727
<212>  PRT
<213>  adeno-associated virus

<400>  26

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Ile Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro 
    130                 135                 140                 


Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys 
145                 150                 155                 160 


Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Ala Ala Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Ser Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Ser Asn Tyr Gly Ala Asn Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Glu Asn Asp Gly Thr Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Asn Gly Leu Gly Phe Ser Gln Ala Gly Pro Thr Ser Met Arg Asn 
    450                 455                 460                 


Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Glu Arg Ser Thr Glu Asn Asn Asn Gly Asp Phe Ser Trp Thr Gly 
                485                 490                 495     


Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Asp Asp Glu Asp Arg Phe Phe Pro Gln 
        515                 520                 525             


Asn Gly Val Leu Ile Phe Gly Thr Pro Asn Ala Thr Ala Ser Asn Thr 
    530                 535                 540                 


Pro Leu Glu Asn Val Leu Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asn Asn Lys Gln 
                565                 570                 575     


Asp Gly Ser Thr Gln Ala Thr Thr Ala Ile Val Asn Ala Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ser Asn Pro Pro Glu Lys Phe Thr Gln Glu 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Val Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe 
    690                 695                 700                 


Thr Val Asp Thr Asn Gly Met Tyr Ser Glu Pro Arg Thr Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  27
<211>  2184
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2184)

<400>  27
atg tcg ttt gtt gat cac ccc cca gat tgg ttg gaa gag gtc ggt gaa         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu           
1               5                   10                  15                

ggc ctt cac gag ttt ttg gag ctc gaa gct ggc cca ccc aaa ccg aag         96
Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag cag gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tat ctg gga ccc ttc aac gga ctc gac aaa gga gag ccc gtc        192
Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro Val           
    50                  55                  60                            

aac cga gcg gac gct gtt gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc aag gac gac acc tcc ttt ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca atc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gca cct gtt aag acg gct cca gcc aag aag cgg ccg        432
Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro           
    130                 135                 140                           

ata gag aag tct ccg gcg gaa ccg agc tct tcg aag ggc att ggc aag        480
Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys           
145                 150                 155                 160           

gcg ggc cag cag cct gcg aga aag cga ctc aac ttt ggt cag act gga        528
Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly           
                165                 170                 175               

gac gcc gac tcc gcc gct gac ccc cag cct ctc gga gaa cca ccc gca        576
Asp Ala Asp Ser Ala Ala Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala           
            180                 185                 190                   

gcc ccc tct ggt ctg gga act ggt acg atg gct tca ggc agt ggc gca        624
Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Ser Gly Ala           
        195                 200                 205                       

cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc tcg        672
Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser           
    210                 215                 220                           

gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac cga gtc atc acc        720
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr           
225                 230                 235                 240           

acc agc acc cgc acc tgg gcc ctg ccc acc tac aac aac cac ctc tac        768
Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr           
                245                 250                 255               

aag caa atc tcc agt agt cag gcc gga gcc aac aac gac aac cac tac        816
Lys Gln Ile Ser Ser Ser Gln Ala Gly Ala Asn Asn Asp Asn His Tyr           
            260                 265                 270                   

ttt ggc tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc cac        864
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His           
        275                 280                 285                       

tgc cac ttc tcc cct cga gac tgg cag cgg ctc atc aac aac aac tgg        912
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp           
    290                 295                 300                           

ggg ttc cgg ccc aag cga ctc aac ttc aag ctg ttc aac atc caa gtc        960
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val           
305                 310                 315                 320           

aag gaa gtt act gaa acg gac ggc acc aag acc atc gcc aat aac ctt       1008
Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn Leu           
                325                 330                 335               

acc agc acg gtt cag gtc ttt gcg gac tcg gag tac cag ctc ccg tat       1056
Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro Tyr           
            340                 345                 350                   

gtc ctc gga tcg gcg cac cag ggt tgc ttc ccg ccg ttc ccg gcg gac       1104
Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala Asp           
        355                 360                 365                       

gtc ttc atg gtc ccg cag tac ggg tat ctg acg ctg aac aac ggc agc       1152
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser           
    370                 375                 380                           

cag gcg atg ggt cgt tcg tcc ttc tac tgt ctg gag tac ttt ccg tcg       1200
Gln Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser           
385                 390                 395                 400           

cag atg ctg cgg acg ggg aac aac ttt aca ttc agc tac acc ttc gag       1248
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu           
                405                 410                 415               

gac gtg ccc ttc cac agc agc tac gcg cac agc cag agt ctg gac cgg       1296
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg           
            420                 425                 430                   

ctc atg aac cca ctc atc gac cag tac ctg tac tac cta agc aag aca       1344
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr           
        435                 440                 445                       

aat ggc ggt cta gga ttt tcc caa gcg gga ccc aac agc atg cgc gac       1392
Asn Gly Gly Leu Gly Phe Ser Gln Ala Gly Pro Asn Ser Met Arg Asp           
    450                 455                 460                           

cag tcc agg aat tgg ctc ccg gga ccc tgc ttc cgt cag cag cga gtt       1440
Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val           
465                 470                 475                 480           

tca gaa aga tcc aca gaa aac aac aac gga gac ttc tcg tgg acg gga       1488
Ser Glu Arg Ser Thr Glu Asn Asn Asn Gly Asp Phe Ser Trp Thr Gly           
                485                 490                 495               

gcc acc aag tat cac ctc aat gga aga aac tcg gcg atg aat cca ggc       1536
Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro Gly           
            500                 505                 510                   

ccg gcc atg gcc agt cac aag gac gac gag gac aga ttc ttt ccg caa       1584
Pro Ala Met Ala Ser His Lys Asp Asp Glu Asp Arg Phe Phe Pro Gln           
        515                 520                 525                       

aac ggc gtg ctc atc ttt gga aca ccg aac gct act gca agt aat aca       1632
Asn Gly Val Leu Ile Phe Gly Thr Pro Asn Ala Thr Ala Ser Asn Thr           
    530                 535                 540                           

cct cta gag aat gta ctg atc act gat gag gag gaa atc aga act acg       1680
Pro Leu Glu Asn Val Leu Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr           
545                 550                 555                 560           

aac cct gtg gcc aca gaa gag tac ggg atc gtt gct aac aat aaa cag       1728
Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asn Asn Lys Gln           
                565                 570                 575               

gac ggc agt aca cag gcg acg aca gcg att gtc aac gca caa ggc atc       1776
Asp Gly Ser Thr Gln Ala Thr Thr Ala Ile Val Asn Ala Gln Gly Ile           
            580                 585                 590                   

ctg ccc ggc atg gtg tgg cag gat cga gat gtg tac ctg cag ggg ccc       1824
Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro           
        595                 600                 605                       

atc tgg gcc aag ata ccc cac acg gat gga cac ttc cac cca tcg ccg       1872
Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro           
    610                 615                 620                           

ctc atg ggc gga ttc ggc ctt aag cat cca cct ccg cag atc ctc atc       1920
Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile           
625                 630                 635                 640           

aag aac acg cct gtg cca tca aac cct cca gaa aag ttc acc cag gaa       1968
Lys Asn Thr Pro Val Pro Ser Asn Pro Pro Glu Lys Phe Thr Gln Glu           
                645                 650                 655               

aaa ctc aat tcc ttc atc aca caa tac tcc acg gga cag gtc agt gtg       2016
Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val           
            660                 665                 670                   

gag atc gag tgg gag ctg cag aag gag aac agc aag cgc tgg aac ccc       2064
Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro           
        675                 680                 685                       

gag gtc caa tac act tcc aac tac aac aag tcc gtc aac gtg gac ttc       2112
Glu Val Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe           
    690                 695                 700                           

acc gtg gac acc aac ggc atg tat tcg gaa ccg cga acc atc gga acc       2160
Thr Val Asp Thr Asn Gly Met Tyr Ser Glu Pro Arg Thr Ile Gly Thr           
705                 710                 715                 720           

cga tac ctt acc cgc aac ctg taa                                       2184
Arg Tyr Leu Thr Arg Asn Leu                                               
                725                                                       


<210>  28
<211>  727
<212>  PRT
<213>  adeno-associated virus

<400>  28

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro 
    130                 135                 140                 


Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys 
145                 150                 155                 160 


Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Ala Ala Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Ser Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Ser Gln Ala Gly Ala Asn Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Glu Thr Asp Gly Thr Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Asn Gly Gly Leu Gly Phe Ser Gln Ala Gly Pro Asn Ser Met Arg Asp 
    450                 455                 460                 


Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Glu Arg Ser Thr Glu Asn Asn Asn Gly Asp Phe Ser Trp Thr Gly 
                485                 490                 495     


Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Asp Asp Glu Asp Arg Phe Phe Pro Gln 
        515                 520                 525             


Asn Gly Val Leu Ile Phe Gly Thr Pro Asn Ala Thr Ala Ser Asn Thr 
    530                 535                 540                 


Pro Leu Glu Asn Val Leu Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asn Asn Lys Gln 
                565                 570                 575     


Asp Gly Ser Thr Gln Ala Thr Thr Ala Ile Val Asn Ala Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ser Asn Pro Pro Glu Lys Phe Thr Gln Glu 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Val Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe 
    690                 695                 700                 


Thr Val Asp Thr Asn Gly Met Tyr Ser Glu Pro Arg Thr Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  29
<211>  2184
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2184)

<400>  29
atg tcg ttt gtt gat cac cct cca gat tgg ttg gaa gag gtc ggt gaa         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu           
1               5                   10                  15                

ggc ctt cac gag ttt ttg gag ctc gaa gct ggc cca ccc aaa ccg aag         96
Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag cag gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tat ctg gga ccc ttc aac gga ctc gac aaa gga gag ccc gtc        192
Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro Val           
    50                  55                  60                            

aac cga gcg gac gct gtt gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc aag gac gac acc tcc ttt ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc gga aag gca atc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gca cct gtt aag acg gct cca gcc aag aag cgg ccg        432
Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro           
    130                 135                 140                           

ata gag aag tct ccg gcg gaa ccg agc tct tcg aag ggc att ggc aag        480
Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys           
145                 150                 155                 160           

gcg ggc cag cag cct gcg aga aag cga ctc aac ttt ggt cag act gga        528
Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly           
                165                 170                 175               

gac gcc gac tcc gcc gct gac ccc cag cct ctc gga gaa cca ccc gca        576
Asp Ala Asp Ser Ala Ala Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala           
            180                 185                 190                   

gcc ccc tct ggt ctg gga act ggt acg atg gct tca ggc agt ggc gca        624
Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Ser Gly Ala           
        195                 200                 205                       

cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc tcg        672
Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser           
    210                 215                 220                           

gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac cga gtc atc acc        720
Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr           
225                 230                 235                 240           

acc agc acc cgc acc tgg gcc ctg ccc acc tac aac aac cac ctc tac        768
Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr           
                245                 250                 255               

aag caa atc tcc tcc agc aat tac gga gcc aat aat gac aac cac tac        816
Lys Gln Ile Ser Ser Ser Asn Tyr Gly Ala Asn Asn Asp Asn His Tyr           
            260                 265                 270                   

ttt ggc tac agc acc ccc tgg ggg tac ttt gac ttc aac cgc ttc cat        864
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His           
        275                 280                 285                       

tgc cac ttc tct cca cga gac tgg cag cgg ctc atc aac aac aat tgg        912
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp           
    290                 295                 300                           

ggg ttc cgt ccc aag cgg ctc aac ttc aag ctg ttc aac atc caa gtc        960
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val           
305                 310                 315                 320           

aag gag gtc acg gaa aat gac ggc acc aag acc atc gcc aat aac ctt       1008
Lys Glu Val Thr Glu Asn Asp Gly Thr Lys Thr Ile Ala Asn Asn Leu           
                325                 330                 335               

acc agc acg gtt cag gtc ttt gcg gat tcg gag tac cag ttg ccg tac       1056
Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro Tyr           
            340                 345                 350                   

gtc ctt ggc tcg gcg cac cag ggc tgc ttc cca ccg ttt ccg gca gac       1104
Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala Asp           
        355                 360                 365                       

gtc ttc atg atc ccg cag tac ggg tac ctg acg cta aac aac ggc agt       1152
Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser           
    370                 375                 380                           

cat gcc atg ggc cgc tcg tcc ttc tac tgc ctg gag tac ttt ccg tcg       1200
His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser           
385                 390                 395                 400           

cag atg ctg cgg acg ggg aac aac ttc acg ttc agc tac acc ttc gag       1248
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu           
                405                 410                 415               

gac gtg ccc ttc cac agc agc tac gcg cac agc cag agc ctg gac cgg       1296
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg           
            420                 425                 430                   

ctc atg aat cct ctc atc gac cag tat ctg tac tac ttg agc aag acg       1344
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr           
        435                 440                 445                       

cag aac ggt ttg ggc ttt tct caa gcg gga ccc acc agc atg cgg aac       1392
Gln Asn Gly Leu Gly Phe Ser Gln Ala Gly Pro Thr Ser Met Arg Asn           
    450                 455                 460                           

cag tcc aga aac tgg ctc ccg gga ccc tgc ttc cgt cag cag cga gtt       1440
Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val           
465                 470                 475                 480           

tca gaa aga tcc aca gaa aac aac aac gga gac ttc tcg tgg acg gga       1488
Ser Glu Arg Ser Thr Glu Asn Asn Asn Gly Asp Phe Ser Trp Thr Gly           
                485                 490                 495               

gcc acc aag tat cac ctc aat gga aga aac tcg gcg atg aat cca ggc       1536
Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro Gly           
            500                 505                 510                   

ccg gcc atg gcc agt cac aag gac gac gag gac aga ttc ttt ccg caa       1584
Pro Ala Met Ala Ser His Lys Asp Asp Glu Asp Arg Phe Phe Pro Gln           
        515                 520                 525                       

aac ggc gtg ctc atc ttt gga aca ccg aac gct act gca agt aat aca       1632
Asn Gly Val Leu Ile Phe Gly Thr Pro Asn Ala Thr Ala Ser Asn Thr           
    530                 535                 540                           

cct cta gag aat gta ctg atc act gat gag gag gaa atc aga act acg       1680
Pro Leu Glu Asn Val Leu Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr           
545                 550                 555                 560           

aac cct gtg gcc aca gaa gag tac ggg atc gtt gct aac aat aaa cag       1728
Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asn Asn Lys Gln           
                565                 570                 575               

gac ggc agt aca cag gcg acg aca gcg att gtc aac gca caa ggc atc       1776
Asp Gly Ser Thr Gln Ala Thr Thr Ala Ile Val Asn Ala Gln Gly Ile           
            580                 585                 590                   

ctg ccc ggc atg gtg tgg cag gat cga gat gtg tac ctg cag ggg ccc       1824
Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro           
        595                 600                 605                       

atc tgg gcc aag ata ccc cac acg gat gga cac ttc cac cca tcg ccg       1872
Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro           
    610                 615                 620                           

ctc atg ggc gga ttc ggc ctt aag cat cca cct ccg cag atc ctc atc       1920
Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile           
625                 630                 635                 640           

aag aac acg cct gtg cca tca aac cct cca gaa aag ttc acc cag gaa       1968
Lys Asn Thr Pro Val Pro Ser Asn Pro Pro Glu Lys Phe Thr Gln Glu           
                645                 650                 655               

aaa ctc aat tcc ttc atc aca caa tac tcc acg gga cag gtc agt gtg       2016
Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val           
            660                 665                 670                   

gag atc gag tgg gag ctg cag aag gag aac agc aag cgc tgg aac ccc       2064
Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro           
        675                 680                 685                       

gag gtc caa tac act tcc aac tac aac aag tcc gtc aac gtg gac ttc       2112
Glu Val Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe           
    690                 695                 700                           

acc gtg gac acc aac ggc atg tat tcg gaa ccg cga acc atc gga acc       2160
Thr Val Asp Thr Asn Gly Met Tyr Ser Glu Pro Arg Thr Ile Gly Thr           
705                 710                 715                 720           

cga tac ctt acc cgc aac ctg taa                                       2184
Arg Tyr Leu Thr Arg Asn Leu                                               
                725                                                       


<210>  30
<211>  727
<212>  PRT
<213>  adeno-associated virus

<400>  30

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu His Glu Phe Leu Glu Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Ala Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Lys Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Ile Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Ala Pro Val Lys Thr Ala Pro Ala Lys Lys Arg Pro 
    130                 135                 140                 


Ile Glu Lys Ser Pro Ala Glu Pro Ser Ser Ser Lys Gly Ile Gly Lys 
145                 150                 155                 160 


Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Ala Asp Ser Ala Ala Asp Pro Gln Pro Leu Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Leu Gly Thr Gly Thr Met Ala Ser Gly Ser Gly Ala 
        195                 200                 205             


Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Ser Ser Asn Tyr Gly Ala Asn Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Glu Asn Asp Gly Thr Lys Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Ala Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Phe Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


His Ala Met Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Gln Asn Gly Leu Gly Phe Ser Gln Ala Gly Pro Thr Ser Met Arg Asn 
    450                 455                 460                 


Gln Ser Arg Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Glu Arg Ser Thr Glu Asn Asn Asn Gly Asp Phe Ser Trp Thr Gly 
                485                 490                 495     


Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Ala Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Asp Asp Glu Asp Arg Phe Phe Pro Gln 
        515                 520                 525             


Asn Gly Val Leu Ile Phe Gly Thr Pro Asn Ala Thr Ala Ser Asn Thr 
    530                 535                 540                 


Pro Leu Glu Asn Val Leu Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asn Asn Lys Gln 
                565                 570                 575     


Asp Gly Ser Thr Gln Ala Thr Thr Ala Ile Val Asn Ala Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ser Asn Pro Pro Glu Lys Phe Thr Gln Glu 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Val Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe 
    690                 695                 700                 


Thr Val Asp Thr Asn Gly Met Tyr Ser Glu Pro Arg Thr Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  31
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  31
atg tcg ttt gtt gat cac ccc cca gat tgg ctt gag gag att ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ctg gga ccc gga aac ggt ctc gac cgt gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gcc gac gag gtc gcg cga gag cac gac atc tcg tac aac gaa        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc gtg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Val Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtg gag gag cct gtt aag acg gct gct aaa gga gag cgg ata        432
Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat ccc aag aag aag aag gct cgg atc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ttg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggt aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cgc acc tgg gtg ctg ccc agc tac aac aac cac aag tac atc gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Lys Tyr Ile Glu           
225                 230                 235                 240           

atc cac agc ggt tcc gtc gac gga agc aat gcc aac gct tac ttt gga        768
Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc acc ccc tgg ggg tac ttt gat ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc ccc cga gac tgg cag cga ctc atc aac aac tac tgg ggc ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc cgg tcc ctc aag gtc aag atc ttt aac atc caa gtc aag gag        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg gtg cag gac gcc acc acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Val Gln Asp Ala Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc caa gtg ttt acg gac aac gac tac cag cta ccg tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acc gag ggg tgc ctc cct gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg acg ctg aac cgc aac aat acc aac       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asn           
        355                 360                 365                       

aat ccc acc gag cgg agc agc ttc ttt tgt ctg gag tac ttt ccc agc       1152
Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg cta cgg acg ggc aac aac ttt gag ttc aca tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gta ccc ttc cac tgc agc ttc gcg ccc agc caa aac ctc ttc aaa       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gct aac ccg ttg gtg gat cag tac ctc tac cgc ttc gtg agc acg       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac aac tcc ggt gcc gtc cag ttc aaa aag aac ctg gcg ggc aga tac       1344
Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr           
        435                 440                 445                       

gcc aat aca tac aag aac tgg ttc cca gga ccc atg tgc cga acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tac aca gga acg ggt ata tat aac aac aaa ggc gct acc agc       1440
Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser           
465                 470                 475                 480           

ttt aac acc tca aac aga atg gac tta gag gga gcc agt tat caa gtg       1488
Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

cct ccc cag ccc aac ggg atg aca aac acg gtt cag gac agc aac ctt       1536
Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg att ttt aac gca caa aac gcc acc ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro           
        515                 520                 525                       

gga acg aat aca acg tat ccg gag gag aac ctt ttg ata acc agt gag       1632
Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag act caa ccc gtg aac aga gtg gct tac agc tcc gga gga caa       1680
Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln           
545                 550                 555                 560           

ata gcc aac aac aat cag aac acc aac acg gct cct act gca gga acc       1728
Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr           
                565                 570                 575               

tac aac cac cag gaa ata cta cct ggc agc gtg tgg atg gac agg gac       1776
Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gtg tac ctc cag gga ccc atc tgg gca aag atc ccg gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cac ttt cat cct tct cca gcc atg ggc gga ttc gga ctc aaa cat cca       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro           
    610                 615                 620                           

ccg ccc atg atg ctc atc aag aac acg ccg gtg cct agc agc gtc acc       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Ser Val Thr           
625                 630                 635                 640           

acc ttc tca gac gtg cct gtc caa agc ttc atc acc cag tac agc acc       1968
Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

ggg cag gtt acc gtg gag atg gaa tgg gag ctc aag aag gaa aac tcc       2016
Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag aga tgg aac ccc gag atc cag tat acc aac aac tac aac aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro           
        675                 680                 685                       

aca ttc gtg gac ttt gct cca gat aaa gaa gga gaa tac agg acc acg       2112
Thr Phe Val Asp Phe Ala Pro Asp Lys Glu Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgc tac ctt acc cga cca ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  32
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  32

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Val Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Lys Tyr Ile Glu 
225                 230                 235                 240 


Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Val Gln Asp Ala Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asn 
        355                 360                 365             


Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser 
465                 470                 475                 480 


Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro 
        515                 520                 525             


Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln 
545                 550                 555                 560 


Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr 
                565                 570                 575     


Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Ser Val Thr 
625                 630                 635                 640 


Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Lys Glu Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  33
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  33
atg tcg ttt gtt gat cac ccc cca gat tgg ctt gag gag att ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ttg gga ccc gga aac ggc ctc gac cgc gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gca gac gag gtc gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gca ggg gac aat ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt caa gag aag ctc gcg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gag cct gct aag acg gct gct aaa gga gag cgg ata        432
Gly Leu Val Glu Glu Pro Ala Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat ccc aag aag aag aag gct cgg atc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ttg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggt aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cgc acc tgg gtg ctg ccc agc tac aac aac cac aag tac atc gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Lys Tyr Ile Glu           
225                 230                 235                 240           

atc cac agc ggt tcc gtc gac gga agc aat gcc aac gct tac ttt gga        768
Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc acc ccc tgg ggg tac ttt gat ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc ccc cga gac tgg cag cga ctc atc aac aac tac tgg ggc ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc cgg tcc ctc aag gtc aag atc ttt aac atc caa gtc aag gag        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg gtg cag gac gcc acc acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Val Gln Asp Ala Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc caa gtg ttt acg gac aac gac tac cag cta ccg tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acc gag ggg tgc ctc cct gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg acg ctg aac cgc aac aat acc aac       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asn           
        355                 360                 365                       

aat ccc acc gag cgg agc agc ttc ttt tgt ctg gag tac ttt ccc agc       1152
Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg cta cgg acg ggc aac aac ttt gag ttc aca tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gta ccc ttc cac tgc agc ttc gcg ccc agc caa aac ctc ttc aaa       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gct aac ccg ttg gtg gat cag tac ctc tac cgc ttc gtg agc acg       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac aac tcc ggt gcc gtc cag ttc aaa aag aac ctg gcg ggc aga tac       1344
Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr           
        435                 440                 445                       

gcc aat aca tac aag aac tgg ttc cca gga ccc atg tgc cga acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tac aca gga acg ggt ata tat aac aac aaa ggc gct acc agc       1440
Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser           
465                 470                 475                 480           

ttt aac acc tca aac aga atg gac cta gag gga gcc agt tat caa gtg       1488
Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

cct ccc cag ccc aac ggg atg aca aac acg gtt cag gac agc aac ctt       1536
Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg att ttt aac gca caa aac gcc acc ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro           
        515                 520                 525                       

gga acg aat aca acg tat ccg gag gag aac ctt ttg ata acc agt gag       1632
Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag act caa ccc gtg aac aga gtg gct tac agc tcc gga gga caa       1680
Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln           
545                 550                 555                 560           

ata gcc aac aac aat cag aac acc aac acg gct cct act gca gga acc       1728
Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr           
                565                 570                 575               

tac aac cac cag gaa ata cta cct ggc agc gtg tgg atg gac agg gac       1776
Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gtg tac ctc cag gga ccc atc tgg gca aag atc ccg gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cac ttt cat cct tct cca gcc atg ggc gga ttc gga ctc aaa cat cca       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro           
    610                 615                 620                           

ccg ccc atg atg ctc atc aag aac acg ccg gtg cct agc aac gtc acc       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Thr           
625                 630                 635                 640           

acc ttc tca gac gtg cct gtc caa agc ttc atc acc cag tac agc acc       1968
Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

ggg cag gtt acc gtg gag atg gaa tgg gag ctc aag aag gaa aac tcc       2016
Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag aga tgg aac ccc gag atc cag tat acc aac aac tac aac aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro           
        675                 680                 685                       

aca ttc gtg gac ttt gct cca gat aaa gaa gga gaa tac agg acc acg       2112
Thr Phe Val Asp Phe Ala Pro Asp Lys Glu Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgc tac ctt acc cga cca ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  34
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  34

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Ala Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Lys Tyr Ile Glu 
225                 230                 235                 240 


Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Val Gln Asp Ala Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asn 
        355                 360                 365             


Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser 
465                 470                 475                 480 


Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro 
        515                 520                 525             


Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln 
545                 550                 555                 560 


Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr 
                565                 570                 575     


Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Thr 
625                 630                 635                 640 


Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Lys Glu Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  35
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  35
atg tcg ttt gtt gat cac ccc cca gat tgg ctt gag gag att ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ctg gga ccc gga aac ggt ctc gac cgt gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gcc gac gag gtc gcg cga gag cac gac atc tcg tac aac gaa        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc gtg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Val Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtg gag gag cct gtt aag acg gct gct aaa gga gag cgg ata        432
Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat ccc aag aag aag aag gct cgg atc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ttg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggt aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cgc acc tgg gtg ctg ccc agc tac aac aac cac aag tac atc gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Lys Tyr Ile Glu           
225                 230                 235                 240           

atc cac agc ggt tcc gtc gac gga agc aat gcc aac gct tac ttt gga        768
Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc acc ccc tgg ggg tac ttt gat ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc ccc cga gac tgg cag cga ctc atc aac aac tac tgg ggc ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc cgg tcc ctc aag gtc aag atc ttt aac atc caa gtc aag gag        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg gtg cag gac gcc acc acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Val Gln Asp Ala Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc caa gtg ttt acg gac aac gac tac cag cta ccg tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acc gag ggg tgc ctc cct gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg acg ctg aac cgc aac aat acc aac       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asn           
        355                 360                 365                       

aat ccc acc gag cgg agc agc ttc ttt tgt ctg gag tac ttt ccc agc       1152
Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg cta cgg acg ggc aac aac ttt gag ttc aca tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gta ccc ttc cac tgc agc ttc gcg ccc agc caa aac ctc ttc aaa       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gct aac ccg ttg gtg gat cag tac ctc tac cgc ttc gtg agc acg       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac aac tcc ggt gcc gtc cag ttc aaa aag aac ctg gcg ggc aga tac       1344
Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr           
        435                 440                 445                       

gcc aat aca tac aag aac tgg ttc cca gga ccc atg tgc cga acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tac aca gga acg ggt ata tat aac aac aaa ggc gct acc agc       1440
Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser           
465                 470                 475                 480           

ttt aac acc tca aac aga atg gac tta gag gga gcc agt tat caa gtg       1488
Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

cct ccc cag ccc aac ggg atg aca aac acg gtt cag gac agc aac ctt       1536
Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg att ttt aac gca caa aac gcc acc ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro           
        515                 520                 525                       

gga acg aat aca acg tat ccg gag gag aac ctt ttg ata acc agt gag       1632
Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag act caa ccc gtg aac aga gtg gct tac agc tcc gga gga caa       1680
Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln           
545                 550                 555                 560           

ata gcc aac aac aat cag aac acc aac acg gct cct act gca gga acc       1728
Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr           
                565                 570                 575               

tac aac cac cag gaa ata cta cct ggc agc gtg tgg atg gac agg gac       1776
Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gtg tac ctc cag gga ccc atc tgg gca aag atc ccg gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cac ttt cat cct tct cca gcc atg ggc gga ttc gga ctc aaa cat cca       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro           
    610                 615                 620                           

ccg ccc atg atg ctc atc aag aac acg ccg gtg cct agc aac gtc acc       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Thr           
625                 630                 635                 640           

acc ttc tca gac gtg cct gtc caa agc ttc atc acc cag tac agc acc       1968
Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

ggg cag gtt acc gtg gag atg gaa tgg gag ctc aag aag gaa aac tcc       2016
Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag aga tgg aac ccc gag atc cag tat acc aac aac tac aac aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro           
        675                 680                 685                       

aca ttc gtg gac ttt gct cca gat aaa gaa gga gaa tac agg acc acg       2112
Thr Phe Val Asp Phe Ala Pro Asp Lys Glu Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgc tac ctt acc cga cca ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  36
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  36

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Val Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Lys Tyr Ile Glu 
225                 230                 235                 240 


Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Val Gln Asp Ala Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asn 
        355                 360                 365             


Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser 
465                 470                 475                 480 


Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro 
        515                 520                 525             


Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln 
545                 550                 555                 560 


Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr 
                565                 570                 575     


Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Thr 
625                 630                 635                 640 


Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Lys Glu Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  37
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  37
atg tcg ttt gtt gat cac ccc cca gat tgg ctt gag gag att ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ttg gga ccc gga aac ggc ctc gac cgc gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gca gac gag gtc gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gca ggg gac aat ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt caa gag aag ctc gcg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gag cct gct aag acg gct gct aaa gga gag cga ata        432
Gly Leu Val Glu Glu Pro Ala Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat cct aag aag aag aag gct cgg gtc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Val Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ttg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggt aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cgc acc tgg gtg ctg ccc agc tac aac aac cac aag tac atc gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Lys Tyr Ile Glu           
225                 230                 235                 240           

atc cac agc ggt tcc gtc gac gga agc aat gcc aac gct tac ttt gga        768
Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc acc ccc tgg ggg tac ttt gat ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc ccc cga gac tgg cag cga ctc atc aac aac tac tgg ggc ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc cgg tcc ctc aag gtc aag atc ttt aac atc caa gtc aag gag        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg gtg cag gac gcc acc acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Val Gln Asp Ala Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc caa gtg ttt acg gac aac gac tac cag cta ccg tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acc gag ggg tgc ctc cct gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg acg ctg aac cgc aac aat acc aac       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asn           
        355                 360                 365                       

aat ccc acc gag cgg agc agc ttc ttt tgt ctg gag tac ttt ccc agc       1152
Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg cta cgg acg ggc aac aac ttt gag ttc aca tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gta ccc ttc cac tgc agc ttc gcg ccc agc caa aac ctc ttc aaa       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gct aac ccg ttg gtg gat cag tac ctc tac cgc ttc gtg agc acg       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac aac tcc ggt gcc gtc cag ttc aaa aag aac ctg gcg ggc aga tac       1344
Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr           
        435                 440                 445                       

gcc aat aca tac aag aac tgg ttc cca gga ccc atg tgc cga acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tac aca gga acg ggt ata tat aac aac aaa ggc gct acc agc       1440
Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser           
465                 470                 475                 480           

ttt aac acc tca aac aga atg gac cta gag gga gcc agt tat caa gtg       1488
Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

cct ccc cag ccc aac ggg atg aca aac acg gtt cag gac agc aac ctt       1536
Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg att ttt aac gca caa aac gcc acc ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro           
        515                 520                 525                       

gga acg aat aca acg tat ccg gag gag aac ctt ttg ata acc agt gag       1632
Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag act caa ccc gtg aac aga gtg gct tac agc tcc gga gga caa       1680
Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln           
545                 550                 555                 560           

ata gcc aac aac aat cag aac acc aac acg gct cct act gca gga acc       1728
Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr           
                565                 570                 575               

tac aac cac cag gaa ata cta cct ggc agc gtg tgg atg gac agg gac       1776
Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gtg tac ctc cag gga ccc atc tgg gca aag atc ccg gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cac ttt cat cct tct cca gcc atg ggc gga ttc gga ctc aaa cat cca       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro           
    610                 615                 620                           

ccg ccc atg atg ctc atc aag aac acg ccg gtg cct agc aac gtc acc       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Thr           
625                 630                 635                 640           

acc ttc tca gac gtg cct gtc caa agc ttc atc acc cag tac agc acc       1968
Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

ggg cag gtt acc gtg gag atg gaa tgg gag ctc aag aag gaa aac tcc       2016
Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag aga tgg aac ccc gag atc cag tat acc aac aac tac aac aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro           
        675                 680                 685                       

aca ttc gtg gac ttt gct cca gat aaa gaa gga gaa tac agg acc acg       2112
Thr Phe Val Asp Phe Ala Pro Asp Lys Glu Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgc tac ctt acc cga cca ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  38
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  38

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Ala Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Val Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Lys Tyr Ile Glu 
225                 230                 235                 240 


Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Val Gln Asp Ala Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Thr Asn 
        355                 360                 365             


Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser 
465                 470                 475                 480 


Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro 
        515                 520                 525             


Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln 
545                 550                 555                 560 


Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr 
                565                 570                 575     


Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Thr 
625                 630                 635                 640 


Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Lys Glu Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  39
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  39
atg tcg ttt gtt gat cac cct cca gat tgg ctt gag gag att ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ctg gga ccc gga aac ggt ctc gac cgt gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gcc gac gag gtc gcg cga gag cac gac atc tcg tac aac gaa        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc gtg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Val Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtg gag gag cct gtt aag acg gct gct aaa gga gag cgg ata        432
Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat ccc aag aag aag aag gct cgg atc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ttg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggt aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cgc acc tgg gtg ctg ccc agc tac aac aac cac aag tac atc gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Lys Tyr Ile Glu           
225                 230                 235                 240           

atc cac agc ggt tcc gtc gac gga agc aat gcc aac gct tac ttt gga        768
Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc act ccc tgg ggg tac ttt gat ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc cct cga gac tgg cag cga ctc atc aac aac tac tgg gga ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc cgg tcc ctc aag gtc aag atc ttt aac atc caa gtc aag gag        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg gtg cag gac aac acc acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Val Gln Asp Asn Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc cag gtg ttt acg gac aac gac tac cag ctg ccg tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acc gag ggg tgt tta ccg gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg aca ctg aac cgc aac aac agc gaa       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Ser Glu           
        355                 360                 365                       

aat cct acc gag cgg agt agc ttc ttc tgt ctg gag tac ttt ccc agc       1152
Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg ctg cgg acg ggc aac aac ttt gag ttc aca tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gta ccc ttc cac tgc agc ttc gcg ccc agc caa aac ctc ttc aaa       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gct aac ccg ttg gtg gat cag tac ctc tac cgc ttc gtg agc acg       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac aac tcc ggt gcc gtc cag ttc aaa aag aac ctg gcg ggc aga tac       1344
Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr           
        435                 440                 445                       

gcc aat aca tac aag aac tgg ttc cca gga ccc atg tgc cga acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tac aca gga acg ggt ata tat aac aac aaa ggc gct acc agc       1440
Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser           
465                 470                 475                 480           

ttt aac acc tca aac aga atg gac cta gag gga gcc agt tat caa gtg       1488
Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

cct ccc cag ccc aac ggg atg aca aac acg gtt cag gac agc aac ctt       1536
Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg att ttt aac gca caa aac gcc acc ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro           
        515                 520                 525                       

gga acg aat aca acg tat ccg gag gag aac ctt ttg ata acc agt gag       1632
Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag act caa ccc gtg aac aga gtg gct tac agc tcc gga gga caa       1680
Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln           
545                 550                 555                 560           

ata gcc aac aac aat cag aac acc aac acg gct cct act gca gga acc       1728
Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr           
                565                 570                 575               

tac aac cac cag gaa ata cta cct ggc agc gtg tgg atg gac agg gac       1776
Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gtg tac ctc cag gga ccc atc tgg gca aag atc ccg gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cac ttt cat cct tct cca gcc atg ggc gga ttc gga ctc aaa cat cca       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro           
    610                 615                 620                           

ccg ccc atg atg ctc atc aag aac acg ccg gtg cct agc aac gtc acc       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Thr           
625                 630                 635                 640           

acc ttc tca gac gtg cct gtc caa agc ttc atc acc cag tac agc acc       1968
Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

ggg cag gtt acc gtg gag atg gaa tgg gag ctc aag aag gaa aac tcc       2016
Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag aga tgg aac ccc gag atc cag tat acc aac aac tac aac aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro           
        675                 680                 685                       

aca ttc gtg gac ttt gct cca gat aaa gaa gga gaa tac agg acc acg       2112
Thr Phe Val Asp Phe Ala Pro Asp Lys Glu Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgc tac ctt acc cga cca ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  40
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  40

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Val Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Ile Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Lys Tyr Ile Glu 
225                 230                 235                 240 


Ile His Ser Gly Ser Val Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Val Gln Asp Asn Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Ser Glu 
        355                 360                 365             


Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser 
465                 470                 475                 480 


Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro 
        515                 520                 525             


Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln 
545                 550                 555                 560 


Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr 
                565                 570                 575     


Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys His Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Ser Asn Val Thr 
625                 630                 635                 640 


Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Lys Glu Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  41
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  41
atg tcg ttt gtt gat cac cct cca gat tgg ctt gag gag att ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ttg gga ccc gga aac ggc ctc gac cgc gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gca gac gag gtc gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gca ggg gac aat ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt caa gag aag ctc gcg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gag cct gct aag acg gct gct aaa gga gag cga ata        432
Gly Leu Val Glu Glu Pro Ala Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat cct aag aag aag aag gct cgg gtc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Val Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga ggc cag cag ctg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Gly Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggc aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc aca tgg atg ggg gac aga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cga acc tgg gtg ctg ccc agc tac aat aac cac ctg tac aaa gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Leu Tyr Lys Glu           
225                 230                 235                 240           

atc cac aac aac ggg gtc gac ggc agc acc gcc aat gcc tac ttt gga        768
Ile His Asn Asn Gly Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc act ccc tgg ggg tac ttt gat ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc cct cga gac tgg cag cga ctc atc aac aac tac tgg gga ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc cgg tcc ctc aag gtc aag atc ttt aac atc caa gtc aag gag        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg gtg cag gac aac acc acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Val Gln Asp Asn Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc cag gtg ttt acg gac aac gac tac cag ctg ccg tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acc gag ggg tgt tta ccg gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg aca ctg aac cgc aac aac agc gaa       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Ser Glu           
        355                 360                 365                       

aat cct acc gag cgg agt agc ttc ttc tgt ctg gag tac ttt ccc agc       1152
Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg ctg cgg acg ggc aac aac ttt gag ttc aca tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gta ccc ttc cac tgc agc ttc gcg ccc agc caa aac ctc ttc aaa       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gct aac ccg ttg gtg gat cag tac ctc tac cgc ttc gtg agc acg       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac aac tcc ggt gcc gtc cag ttc aaa aag aac ctg gcg ggc aga tac       1344
Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr           
        435                 440                 445                       

gcc aat aca tac aag aac tgg ttc cca gga ccc atg tgc cga acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tac aca gga acg ggt ata tat aac aac aaa ggc gct acc agc       1440
Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser           
465                 470                 475                 480           

ttt aac acc tca aac aga atg gac cta gag gga gcc agt tat caa gtg       1488
Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

cct ccc cag ccc aac ggg atg aca aac acg gtt cag gac agc aac ctt       1536
Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg att ttt aac gca caa aac gcc acc ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro           
        515                 520                 525                       

gga acg aat aca acg tat ccg gag gag aac ctt ttg ata acc agt gag       1632
Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag act caa ccc gtg aac aga gtg gct tac agc tcc gga gga cag       1680
Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln           
545                 550                 555                 560           

ata gcc aac aac aat cag aat acc aac acg gct cct act gca gga acc       1728
Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr           
                565                 570                 575               

tac aac cac cag gaa ata cta cct ggc agc gtg tgg atg gac agg gac       1776
Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gtg tac ctc cag ggt ccc atc tgg gcc aag atc cca gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cac ttt cat cct tct cca gcc atg ggc ggg ttc gga ctc aaa tac ccg       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys Tyr Pro           
    610                 615                 620                           

cct ccc atg atg cta atc aag aac acg cca gtg ccc gga aac atc acc       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile Thr           
625                 630                 635                 640           

acc ttc tcg gac gtg ccc gtc caa agt ttt att acc cag tac agc acc       1968
Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

gga cag gtc acc gtg gag atg gag tgg gag ctc aag aaa gaa aac tct       2016
Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag agg tgg aac ccc gag ata cag tac acc aac aac tac aac aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro           
        675                 680                 685                       

acg ttc gtg gac ttt gct cca gac aca gaa gga gaa tac agg acc act       2112
Thr Phe Val Asp Phe Ala Pro Asp Thr Glu Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgc tac ctt acc cga ccc ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  42
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  42

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Ala Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Val Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Gly Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Leu Tyr Lys Glu 
225                 230                 235                 240 


Ile His Asn Asn Gly Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Val Gln Asp Asn Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Ser Glu 
        355                 360                 365             


Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser 
465                 470                 475                 480 


Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro 
        515                 520                 525             


Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln 
545                 550                 555                 560 


Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr 
                565                 570                 575     


Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys Tyr Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile Thr 
625                 630                 635                 640 


Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Thr Glu Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  43
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  43
atg tcg ttt gtt gat cac ccc cca gat tgg ctt gag gag att ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ttg gga ccc gga aac ggc ctc gac cgc gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aac cgg gcc gac gag gtc gcg cga gag cac gac atc tcg tac aac gaa        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aac ccc tac ctc aag tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc gtg gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Val Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtg gag gag cct gtt aag acg gct gct aaa gga gag cgg ata        432
Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat cct aag aag aag aag gct cgg gtc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Val Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga ggc cag cag ctg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Gly Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggc aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc aca tgg atg ggg gac aga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cga acc tgg gtg ctg ccc agc tac aat aac cac ctg tac aaa gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Leu Tyr Lys Glu           
225                 230                 235                 240           

atc cac aac aac ggg gtc gac ggc agc acc gcc aat gcc tac ttt gga        768
Ile His Asn Asn Gly Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc act ccc tgg ggg tac ttt gat ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc cct cga gac tgg cag cga ctc atc aac aac tac tgg gga ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc cgg tcc ctc aag gtc aag atc ttt aac atc caa gtc aag gag        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg gtg cag gac aac acc acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Val Gln Asp Asn Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc cag gtg ttt acg gac aac gac tac cag ctg ccg tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acc gag ggg tgt tta ccg gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg aca ctg aac cgc aac aac agc gaa       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Ser Glu           
        355                 360                 365                       

aat cct acc gag cgg agt agc ttc ttc tgt ctg gag tac ttt ccc agc       1152
Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg ctg cgg acg ggc aac aac ttt gag ttc aca tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gta ccc ttc cac tgc agc ttc gcg ccc agc caa aac ctc ttc aaa       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gct aac ccg ttg gtg gat cag tac ctc tac cgc ttc gtg agc acg       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac aac tcc ggt gcc gtc cag ttc aaa aag aac ctg gcg ggc aga tac       1344
Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr           
        435                 440                 445                       

gcc aat aca tac aag aac tgg ttc cca gga ccc atg tgc cga acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tac aca gga acg ggt ata tat aac aac aaa ggc gct acc agc       1440
Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser           
465                 470                 475                 480           

ttt aac acc tca aac aga atg gac cta gag gga gcc agt tat caa gtg       1488
Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

cct ccc cag ccc aac ggg atg aca aac acg gtt cag gac agc aac ctt       1536
Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg att ttt aac gca caa aac gcc acc ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro           
        515                 520                 525                       

gga acg aat aca acg tat ccg gag gag aac ctt ttg ata acc agt gag       1632
Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag act caa ccc gtg aac aga gtg gct tac agc tcc gga gga cag       1680
Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln           
545                 550                 555                 560           

ata gcc aac aac aat cag aat acc aac acg gct cct act gca gga acc       1728
Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr           
                565                 570                 575               

tac aac cac cag gaa ata cta cct ggc agc gtg tgg atg gac agg gac       1776
Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gtg tac ctc cag ggt ccc atc tgg gcc aag atc cca gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cac ttt cat cct tct cca gcc atg ggc ggg ttc gga ctc aaa tac ccg       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys Tyr Pro           
    610                 615                 620                           

cct ccc atg atg cta atc aag aac acg cca gtg ccc gga aac atc acc       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile Thr           
625                 630                 635                 640           

acc ttc tcg gac gtg ccc gtc caa agt ttt att acc cag tac agc acc       1968
Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

gga cag gtc acc gtg gag atg gag tgg gag ctc aag aaa gaa aac tct       2016
Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag agg tgg aac ccc gag ata cag tac acc aac aac tac aac aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro           
        675                 680                 685                       

acg ttc gtg gac ttt gct cca gac aca gaa gga gaa tac agg acc act       2112
Thr Phe Val Asp Phe Ala Pro Asp Thr Glu Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgc tac ctt acc cga ccc ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  44
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  44

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Val Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Val Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Gly Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Leu Tyr Lys Glu 
225                 230                 235                 240 


Ile His Asn Asn Gly Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Val Gln Asp Asn Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Ser Glu 
        355                 360                 365             


Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser 
465                 470                 475                 480 


Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro 
        515                 520                 525             


Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln 
545                 550                 555                 560 


Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr 
                565                 570                 575     


Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys Tyr Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile Thr 
625                 630                 635                 640 


Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Thr Glu Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  45
<211>  2151
<212>  DNA
<213>  adeno-associated virus


<220>
<221>  CDS
<222>  (1)..(2151)

<400>  45
atg tcg ttt gtt gat cac cct cca gat tgg ctt gag gag atc ggt gag         48
Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu           
1               5                   10                  15                

ggt cta aag gag ttt ttg gga ctc gaa cct ggc cca ccc aaa ccg aag         96
Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys           
            20                  25                  30                    

ccc aac cag cag aag caa gac aac gcc cgt ggt ctt gta ctg cct gga        144
Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly           
        35                  40                  45                        

tat aat tac ctg gga ccc gga aac ggt ctc gac cgc gga gaa cct gtc        192
Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val           
    50                  55                  60                            

aat cgg gcc gac gag gtc gcg cga gag cac gac atc tcg tac aac gag        240
Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu           
65                  70                  75                  80            

cag ctc cag gcg gga gac aat ccc tac ctc aaa tac aac cac gcg gac        288
Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp           
                85                  90                  95                

gcc gag ttt cag gag aag ctc gca gac gac acc tcc ttc ggg ggc aac        336
Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn           
            100                 105                 110                   

ctc ggc aag gca gtc ttt cag gcc aag aaa agg gtt ctc gaa cct ttt        384
Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe           
        115                 120                 125                       

ggc ctg gtt gag gag cct gtt aag acg gct gct aaa ggc gag cga ata        432
Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile           
    130                 135                 140                           

gac gac cac tat cct aag aaa aag aag gct cgt gtc gaa gag acc gaa        480
Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Val Glu Glu Thr Glu           
145                 150                 155                 160           

gct gga acc agc gga gcc cag cag ctg cag atc cca gcc caa cca gcc        528
Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala           
                165                 170                 175               

tca agt ttg gga gct gat aca atg tct gcg gga ggt ggc agc cca ctg        576
Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu           
            180                 185                 190                   

ggc gac aat aac caa ggc gcc gat gga gtg ggc aat gcc tcg gga gat        624
Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp           
        195                 200                 205                       

tgg cat tgc gat tcc acg tgg atg ggg gac cga gtc atc acc aag tcc        672
Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser           
    210                 215                 220                           

acc cga acc tgg gtg ctg ccc agc tac aat aac cac ctg tac aaa gag        720
Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Leu Tyr Lys Glu           
225                 230                 235                 240           

atc cac aac aac ggg gtc gac ggc agc acc gcc aat gcc tac ttt gga        768
Ile His Asn Asn Gly Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly           
                245                 250                 255               

tac agc act ccc tgg ggg tac ttt gat ttc aac cgc ttc cac agc cac        816
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His           
            260                 265                 270                   

tgg agc cct cga gac tgg cag cga ctc atc aac aac tac tgg gga ttc        864
Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe           
        275                 280                 285                       

aga ccc cgg tcc ctc aag gtc aag atc ttt aac atc caa gtc aag gag        912
Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu           
    290                 295                 300                           

gtc acg gtg cag gac aac acc acc acc atc gcc aac aac ctc acc tcc        960
Val Thr Val Gln Asp Asn Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser           
305                 310                 315                 320           

acc gtc cag gtg ttt acg gac aac gac tac cag ctg ccg tac gtc atc       1008
Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile           
                325                 330                 335               

ggc aac ggg acc gag ggg tgt tta ccg gcc ttc cct ccg cag gtc ttt       1056
Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe           
            340                 345                 350                   

acg ctg ccg cag tac ggc tac gcg aca ctg aac cgc aac aac agc gaa       1104
Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Ser Glu           
        355                 360                 365                       

aat cct acc gag cgg agt agc ttc ttc tgt ctg gag tac ttt ccc agc       1152
Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser           
    370                 375                 380                           

aag atg ctg cgg acg ggc aac aac ttt gag ttc aca tac agc ttc gag       1200
Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu           
385                 390                 395                 400           

gag gta ccc ttc cac tgc agc ttc gcg ccc agc caa aac ctc ttc aaa       1248
Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys           
                405                 410                 415               

ctg gct aac ccg ttg gtg gat cag tac ctc tac cgc ttc gtg agc acg       1296
Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr           
            420                 425                 430                   

gac aac tcc ggt gcc gtc cag ttc aaa aag aac ctg gcg ggc aga tac       1344
Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr           
        435                 440                 445                       

gcc aat aca tac aag aac tgg ttc cca gga ccc atg tgc cga acc cag       1392
Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln           
    450                 455                 460                           

ggc tgg tac aca gga acg ggt ata tat aac aac aaa ggc gct acc agc       1440
Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser           
465                 470                 475                 480           

ttt aac acc tca aac aga atg gac cta gag gga gcc agt tat caa gtg       1488
Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val           
                485                 490                 495               

cct ccc cag ccc aac ggg atg aca aac acg gtt cag gac agc aac ctt       1536
Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu           
            500                 505                 510                   

tac gcg ctg gaa aac acc atg att ttt aac gca caa aac gcc acc ccg       1584
Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro           
        515                 520                 525                       

gga acg aat aca acg tat ccg gag gag aac ctt ttg ata acc agt gag       1632
Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu           
    530                 535                 540                           

agc gag act caa ccc gtg aac aga gtg gct tac agc tcc gga gga cag       1680
Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln           
545                 550                 555                 560           

ata gcc aac aac aat cag aat acc aac acg gct cct act gca gga acc       1728
Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr           
                565                 570                 575               

tac aac cac cag gaa ata cta cct ggc agc gtg tgg atg gac agg gac       1776
Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp           
            580                 585                 590                   

gtg tac ctc cag ggt ccc atc tgg gcc aag atc cca gag aca ggg gca       1824
Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala           
        595                 600                 605                       

cac ttt cat cct tct cca gcc atg ggc ggg ttc gga ctc aaa tac ccg       1872
His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys Tyr Pro           
    610                 615                 620                           

cct ccc atg atg cta atc aag aac acg cca gtg ccc gga aac atc acc       1920
Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile Thr           
625                 630                 635                 640           

acc ttc tcg gac gtg ccc gtc caa agt ttt att acc cag tac agc acc       1968
Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr           
                645                 650                 655               

gga cag gtc acc gtg gag atg gag tgg gag ctc aag aaa gaa aac tct       2016
Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser           
            660                 665                 670                   

aag agg tgg aac ccc gag ata cag tac acc aac aac tac aac aac cct       2064
Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro           
        675                 680                 685                       

acg ttc gtg gac ttt gct cca gac aca gaa gga gaa tac agg acc act       2112
Thr Phe Val Asp Phe Ala Pro Asp Thr Glu Gly Glu Tyr Arg Thr Thr           
    690                 695                 700                           

agg gct att gga acc cgc tac ctt acc cga ccc ctg taa                   2151
Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu                           
705                 710                 715                               


<210>  46
<211>  716
<212>  PRT
<213>  adeno-associated virus

<400>  46

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Ile Gly Glu 
1               5                   10                  15      


Gly Leu Lys Glu Phe Leu Gly Leu Glu Pro Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln Lys Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Pro Val Lys Thr Ala Ala Lys Gly Glu Arg Ile 
    130                 135                 140                 


Asp Asp His Tyr Pro Lys Lys Lys Lys Ala Arg Val Glu Glu Thr Glu 
145                 150                 155                 160 


Ala Gly Thr Ser Gly Ala Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala 
                165                 170                 175     


Ser Ser Leu Gly Ala Asp Thr Met Ser Ala Gly Gly Gly Ser Pro Leu 
            180                 185                 190         


Gly Asp Asn Asn Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp 
        195                 200                 205             


Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile Thr Lys Ser 
    210                 215                 220                 


Thr Arg Thr Trp Val Leu Pro Ser Tyr Asn Asn His Leu Tyr Lys Glu 
225                 230                 235                 240 


Ile His Asn Asn Gly Val Asp Gly Ser Thr Ala Asn Ala Tyr Phe Gly 
                245                 250                 255     


Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Ser His 
            260                 265                 270         


Trp Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe 
        275                 280                 285             


Arg Pro Arg Ser Leu Lys Val Lys Ile Phe Asn Ile Gln Val Lys Glu 
    290                 295                 300                 


Val Thr Val Gln Asp Asn Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser 
305                 310                 315                 320 


Thr Val Gln Val Phe Thr Asp Asn Asp Tyr Gln Leu Pro Tyr Val Ile 
                325                 330                 335     


Gly Asn Gly Thr Glu Gly Cys Leu Pro Ala Phe Pro Pro Gln Val Phe 
            340                 345                 350         


Thr Leu Pro Gln Tyr Gly Tyr Ala Thr Leu Asn Arg Asn Asn Ser Glu 
        355                 360                 365             


Asn Pro Thr Glu Arg Ser Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser 
    370                 375                 380                 


Lys Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Thr Tyr Ser Phe Glu 
385                 390                 395                 400 


Glu Val Pro Phe His Cys Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys 
                405                 410                 415     


Leu Ala Asn Pro Leu Val Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr 
            420                 425                 430         


Asp Asn Ser Gly Ala Val Gln Phe Lys Lys Asn Leu Ala Gly Arg Tyr 
        435                 440                 445             


Ala Asn Thr Tyr Lys Asn Trp Phe Pro Gly Pro Met Cys Arg Thr Gln 
    450                 455                 460                 


Gly Trp Tyr Thr Gly Thr Gly Ile Tyr Asn Asn Lys Gly Ala Thr Ser 
465                 470                 475                 480 


Phe Asn Thr Ser Asn Arg Met Asp Leu Glu Gly Ala Ser Tyr Gln Val 
                485                 490                 495     


Pro Pro Gln Pro Asn Gly Met Thr Asn Thr Val Gln Asp Ser Asn Leu 
            500                 505                 510         


Tyr Ala Leu Glu Asn Thr Met Ile Phe Asn Ala Gln Asn Ala Thr Pro 
        515                 520                 525             


Gly Thr Asn Thr Thr Tyr Pro Glu Glu Asn Leu Leu Ile Thr Ser Glu 
    530                 535                 540                 


Ser Glu Thr Gln Pro Val Asn Arg Val Ala Tyr Ser Ser Gly Gly Gln 
545                 550                 555                 560 


Ile Ala Asn Asn Asn Gln Asn Thr Asn Thr Ala Pro Thr Ala Gly Thr 
                565                 570                 575     


Tyr Asn His Gln Glu Ile Leu Pro Gly Ser Val Trp Met Asp Arg Asp 
            580                 585                 590         


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro Glu Thr Gly Ala 
        595                 600                 605             


His Phe His Pro Ser Pro Ala Met Gly Gly Phe Gly Leu Lys Tyr Pro 
    610                 615                 620                 


Pro Pro Met Met Leu Ile Lys Asn Thr Pro Val Pro Gly Asn Ile Thr 
625                 630                 635                 640 


Thr Phe Ser Asp Val Pro Val Gln Ser Phe Ile Thr Gln Tyr Ser Thr 
                645                 650                 655     


Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser 
            660                 665                 670         


Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr Asn Asn Pro 
        675                 680                 685             


Thr Phe Val Asp Phe Ala Pro Asp Thr Glu Gly Glu Tyr Arg Thr Thr 
    690                 695                 700                 


Arg Ala Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
705                 710                 715     


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  47

Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210>  48
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  48
caaaacgtcg tgagacagtt tg                                                22


<210>  49
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  49
agtgaattct accagtgcca ta                                                22


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  50
agcaaaaatg tgctagtgcc aaa                                               23


<210>  51
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  51
agtgtgagtt ctaccattgc caaa                                              24


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  52
agggattcct gggaaaactg gac                                               23


