                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Shokat, Kevan  M
       Hu, Qi
       Dai, Shizhong
 
<120>  G-alpha-s Inhibitors and Uses Thereof

<130>  048536-707001WO

<150>  US 63/179,969
<151>  2021-04-26

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
65                  70                  75                  80  


Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys 
                85                  90                  95      


Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn 
            100                 105                 110         


Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val 
        115                 120                 125             


Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro 
    130                 135                 140                 


Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg 
145                 150                 155                 160 


Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln 
                165                 170                 175     


Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro 
            180                 185                 190         


Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe 
        195                 200                 205             


Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val 
    210                 215                 220                 


Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp 
225                 230                 235                 240 


Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val 
                245                 250                 255     


Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu 
            260                 265                 270         


Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile 
        275                 280                 285             


Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly 
    290                 295                 300                 


Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr 
305                 310                 315                 320 


Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg 
                325                 330                 335     


Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser 
            340                 345                 350         


Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp 
        355                 360                 365             


Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln 
    370                 375                 380                 


Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
385                 390                 


<210>  2
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  2

His Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu 
1               5                   10                  15      


Glu Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln 
            20                  25                  30          


Lys Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly 
        35                  40                  45              


Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu 
    50                  55                  60                  


His Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln 
65                  70                  75                  80  


Asp Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala 
                85                  90                  95      


Met Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln 
            100                 105                 110         


Phe Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp 
        115                 120                 125             


Phe Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu 
    130                 135                 140                 


Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp 
145                 150                 155                 160 


Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp 
                165                 170                 175     


Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser 
            180                 185                 190         


Gly Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met 
        195                 200                 205             


Phe Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys 
    210                 215                 220                 


Phe Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr 
225                 230                 235                 240 


Asn Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala 
                245                 250                 255     


Leu Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile 
            260                 265                 270         


Ser Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val 
        275                 280                 285             


Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg 
    290                 295                 300                 


Tyr Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg 
305                 310                 315                 320 


Val Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser 
                325                 330                 335     


Thr Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys 
            340                 345                 350         


Ala Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp 
        355                 360                 365             


Ile Ile Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
    370                 375                 380     


