                         SEQUENCE LISTING

<110>  University of Massachusetts
 
<120>  GENE THERAPIES FOR STARGARDT DISEASE (ABCA4)

<130>  U0120.70165WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/179,663
<151>  2021-04-26

<150>  US 63/186,753
<151>  2021-05-10

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  7328
<212>  DNA
<213>  Homo sapiens

<400>  1
ggacacagcg tccggagcca gaggcgctct taacggcgtt tatgtccttt gctgtctgag       60

gggcctcagc tctgaccaat ctggtcttcg tgtggtcatt agcatgggct tcgtgagaca      120

gatacagctt ttgctctgga agaactggac cctgcggaaa aggcaaaaga ttcgctttgt      180

ggtggaactc gtgtggcctt tatctttatt tctggtcttg atctggttaa ggaatgccaa      240

cccactctac agccatcatg aatgccattt ccccaacaag gcgatgccct cagcaggaat      300

gctgccgtgg ctccagggga tcttctgcaa tgtgaacaat ccctgttttc aaagccccac      360

cccaggagaa tctcctggaa ttgtgtcaaa ctataacaac tccatcttgg caagggtata      420

tcgagatttt caagaactcc tcatgaatgc accagagagc cagcaccttg gccgtatttg      480

gacagagcta cacatcttgt cccaattcat ggacaccctc cggactcacc cggagagaat      540

tgcaggaaga ggaatacgaa taagggatat cttgaaagat gaagaaacac tgacactatt      600

tctcattaaa aacatcggcc tgtctgactc agtggtctac cttctgatca actctcaagt      660

ccgtccagag cagttcgctc atggagtccc ggacctggcg ctgaaggaca tcgcctgcag      720

cgaggccctc ctggagcgct tcatcatctt cagccagaga cgcggggcaa agacggtgcg      780

ctatgccctg tgctccctct cccagggcac cctacagtgg atagaagaca ctctgtatgc      840

caacgtggac ttcttcaagc tcttccgtgt gcttcccaca ctcctagaca gccgttctca      900

aggtatcaat ctgagatctt ggggaggaat attatctgat atgtcaccaa gaattcaaga      960

gtttatccat cggccgagta tgcaggactt gctgtgggtg accaggcccc tcatgcagaa     1020

tggtggtcca gagaccttta caaagctgat gggcatcctg tctgacctcc tgtgtggcta     1080

ccccgaggga ggtggctctc gggtgctctc cttcaactgg tatgaagaca ataactataa     1140

ggcctttctg gggattgact ccacaaggaa ggatcctatc tattcttatg acagaagaac     1200

aacatccttt tgtaatgcat tgatccagag cctggagtca aatcctttaa ccaaaatcgc     1260

ttggagggcg gcaaagcctt tgctgatggg aaaaatcctg tacactcctg attcacctgc     1320

agcacgaagg atactgaaga atgccaactc aacttttgaa gaactggaac acgttaggaa     1380

gttggtcaaa gcctgggaag aagtagggcc ccagatctgg tacttctttg acaacagcac     1440

acagatgaac atgatcagag ataccctggg gaacccaaca gtaaaagact ttttgaatag     1500

gcagcttggt gaagaaggta ttactgctga agccatccta aacttcctct acaagggccc     1560

tcgggaaagc caggctgacg acatggccaa cttcgactgg agggacatat ttaacatcac     1620

tgatcgcacc ctccgcctgg tcaatcaata cctggagtgc ttggtcctgg ataagtttga     1680

aagctacaat gatgaaactc agctcaccca acgtgccctc tctctactgg aggaaaacat     1740

gttctgggcc ggagtggtat tccctgacat gtatccctgg accagctctc taccacccca     1800

cgtgaagtat aagatccgaa tggacataga cgtggtggag aaaaccaata agattaaaga     1860

caggtattgg gattctggtc ccagagctga tcccgtggaa gatttccggt acatctgggg     1920

cgggtttgcc tatctgcagg acatggttga acaggggatc acaaggagcc aggtgcaggc     1980

ggaggctcca gttggaatct acctccagca gatgccctac ccctgcttcg tggacgattc     2040

tttcatgatc atcctgaacc gctgtttccc tatcttcatg gtgctggcat ggatctactc     2100

tgtctccatg actgtgaaga gcatcgtctt ggagaaggag ttgcgactga aggagacctt     2160

gaaaaatcag ggtgtctcca atgcagtgat ttggtgtacc tggttcctgg acagcttctc     2220

catcatgtcg atgagcatct tcctcctgac gatattcatc atgcatggaa gaatcctaca     2280

ttacagcgac ccattcatcc tcttcctgtt cttgttggct ttctccactg ccaccatcat     2340

gctgtgcttt ctgctcagca ccttcttctc caaggccagt ctggcagcag cctgtagtgg     2400

tgtcatctat ttcaccctct acctgccaca catcctgtgc ttcgcctggc aggaccgcat     2460

gaccgctgag ctgaagaagg ctgtgagctt actgtctccg gtggcatttg gatttggcac     2520

tgagtacctg gttcgctttg aagagcaagg cctggggctg cagtggagca acatcgggaa     2580

cagtcccacg gaaggggacg aattcagctt cctgctgtcc atgcagatga tgctccttga     2640

tgctgctgtc tatggcttac tcgcttggta ccttgatcag gtgtttccag gagactatgg     2700

aaccccactt ccttggtact ttcttctaca agagtcgtat tggcttggcg gtgaagggtg     2760

ttcaaccaga gaagaaagag ccctggaaaa gaccgagccc ctaacagagg aaacggagga     2820

tccagagcac ccagaaggaa tacacgactc cttctttgaa cgtgagcatc cagggtgggt     2880

tcctggggta tgcgtgaaga atctggtaaa gatttttgag ccctgtggcc ggccagctgt     2940

ggaccgtctg aacatcacct tctacgagaa ccagatcacc gcattcctgg gccacaatgg     3000

agctgggaaa accaccacct tgtccatcct gacgggtctg ttgccaccaa cctctgggac     3060

tgtgctcgtt gggggaaggg acattgaaac cagcctggat gcagtccggc agagccttgg     3120

catgtgtcca cagcacaaca tcctgttcca ccacctcacg gtggctgagc acatgctgtt     3180

ctatgcccag ctgaaaggaa agtcccagga ggaggcccag ctggagatgg aagccatgtt     3240

ggaggacaca ggcctccacc acaagcggaa tgaagaggct caggacctat caggtggcat     3300

gcagagaaag ctgtcggttg ccattgcctt tgtgggagat gccaaggtgg tgattctgga     3360

cgaacccacc tctggggtgg acccttactc gagacgctca atctgggatc tgctcctgaa     3420

gtatcgctca ggcagaacca tcatcatgtc cactcaccac atggacgagg ccgacctcct     3480

tggggaccgc attgccatca ttgcccaggg aaggctctac tgctcaggca ccccactctt     3540

cctgaagaac tgctttggca caggcttgta cttaaccttg gtgcgcaaga tgaaaaacat     3600

ccagagccaa aggaaaggca gtgaggggac ctgcagctgc tcgtctaagg gtttctccac     3660

cacgtgtcca gcccacgtcg atgacctaac tccagaacaa gtcctggatg gggatgtaaa     3720

tgagctgatg gatgtagttc tccaccatgt tccagaggca aagctggtgg agtgcattgg     3780

tcaagaactt atcttccttc ttccaaataa gaacttcaag cacagagcat atgccagcct     3840

tttcagagag ctggaggaga cgctggctga ccttggtctc agcagttttg gaatttctga     3900

cactcccctg gaagagattt ttctgaaggt cacggaggat tctgattcag gacctctgtt     3960

tgcgggtggc gctcagcaga aaagagaaaa cgtcaacccc cgacacccct gcttgggtcc     4020

cagagagaag gctggacaga caccccagga ctccaatgtc tgctccccag gggcgccggc     4080

tgctcaccca gagggccagc ctcccccaga gccagagtgc ccaggcccgc agctcaacac     4140

ggggacacag ctggtcctcc agcatgtgca ggcgctgctg gtcaagagat tccaacacac     4200

catccgcagc cacaaggact tcctggcgca gatcgtgctc ccggctacct ttgtgttttt     4260

ggctctgatg ctttctattg ttatccctcc ttttggcgaa taccccgctt tgacccttca     4320

cccctggata tatgggcagc agtacacctt cttcagcatg gatgaaccag gcagtgagca     4380

gttcacggta cttgcagacg tcctcctgaa taagccaggc tttggcaacc gctgcctgaa     4440

ggaagggtgg cttccggagt acccctgtgg caactcaaca ccctggaaga ctccttctgt     4500

gtccccaaac atcacccagc tgttccagaa gcagaaatgg acacaggtca acccttcacc     4560

atcctgcagg tgcagcacca gggagaagct caccatgctg ccagagtgcc ccgagggtgc     4620

cgggggcctc ccgccccccc agagaacaca gcgcagcacg gaaattctac aagacctgac     4680

ggacaggaac atctccgact tcttggtaaa aacgtatcct gctcttataa gaagcagctt     4740

aaagagcaaa ttctgggtca atgaacagag gtatggagga atttccattg gaggaaagct     4800

cccagtcgtc cccatcacgg gggaagcact tgttgggttt ttaagcgacc ttggccggat     4860

catgaatgtg agcgggggcc ctatcactag agaggcctct aaagaaatac ctgatttcct     4920

taaacatcta gaaactgaag acaacattaa ggtgtggttt aataacaaag gctggcatgc     4980

cctggtcagc tttctcaatg tggcccacaa cgccatctta cgggccagcc tgcctaagga     5040

caggagcccc gaggagtatg gaatcaccgt cattagccaa cccctgaacc tgaccaagga     5100

gcagctctca gagattacag tgctgaccac ttcagtggat gctgtggttg ccatctgcgt     5160

gattttctcc atgtccttcg tcccagccag ctttgtcctt tatttgatcc aggagcgggt     5220

gaacaaatcc aagcacctcc agtttatcag tggagtgagc cccaccacct actgggtgac     5280

caacttcctc tgggacatca tgaattattc cgtgagtgct gggctggtgg tgggcatctt     5340

catcgggttt cagaagaaag cctacacttc tccagaaaac cttcctgccc ttgtggcact     5400

gctcctgctg tatggatggg cggtcattcc catgatgtac ccagcatcct tcctgtttga     5460

tgtccccagc acagcctatg tggctttatc ttgtgctaat ctgttcatcg gcatcaacag     5520

cagtgctatt accttcatct tggaattatt tgagaataac cggacgctgc tcaggttcaa     5580

cgccgtgctg aggaagctgc tcattgtctt cccccacttc tgcctgggcc ggggcctcat     5640

tgaccttgca ctgagccagg ctgtgacaga tgtctatgcc cggtttggtg aggagcactc     5700

tgcaaatccg ttccactggg acctgattgg gaagaacctg tttgccatgg tggtggaagg     5760

ggtggtgtac ttcctcctga ccctgctggt ccagcgccac ttcttcctct cccaatggat     5820

tgccgagccc actaaggagc ccattgttga tgaagatgat gatgtggctg aagaaagaca     5880

aagaattatt actggtggaa ataaaactga catcttaagg ctacatgaac taaccaagat     5940

ttatccaggc acctccagcc cagcagtgga caggctgtgt gtcggagttc gccctggaga     6000

gtgctttggc ctcctgggag tgaatggtgc cggcaaaaca accacattca agatgctcac     6060

tggggacacc acagtgacct caggggatgc caccgtagca ggcaagagta ttttaaccaa     6120

tatttctgaa gtccatcaaa atatgggcta ctgtcctcag tttgatgcaa ttgatgagct     6180

gctcacagga cgagaacatc tttaccttta tgcccggctt cgaggtgtac cagcagaaga     6240

aatcgaaaag gttgcaaact ggagtattaa gagcctgggc ctgactgtct acgccgactg     6300

cctggctggc acgtacagtg ggggcaacaa gcggaaactc tccacagcca tcgcactcat     6360

tggctgccca ccgctggtgc tgctggatga gcccaccaca gggatggacc cccaggcacg     6420

ccgcatgctg tggaacgtca tcgtgagcat catcagagaa gggagggctg tggtcctcac     6480

atcccacagc atggaagaat gtgaggcact gtgtacccgg ctggccatca tggtaaaggg     6540

cgcctttcga tgtatgggca ccattcagca tctcaagtcc aaatttggag atggctatat     6600

cgtcacaatg aagatcaaat ccccgaagga cgacctgctt cctgacctga accctgtgga     6660

gcagttcttc caggggaact tcccaggcag tgtgcagagg gagaggcact acaacatgct     6720

ccagttccag gtctcctcct cctccctggc gaggatcttc cagctcctcc tctcccacaa     6780

ggacagcctg ctcatcgagg agtactcagt cacacagacc acactggacc aggtgtttgt     6840

aaattttgct aaacagcaga ctgaaagtca tgacctccct ctgcaccctc gagctgctgg     6900

agccagtcga caagcccagg actgatcttt cacaccgctc gttcctgcag ccagaaagga     6960

actctgggca gctggaggcg caggagcctg tgcccatatg gtcatccaaa tggactggcc     7020

agcgtaaatg accccactgc agcagaaaac aaacacacga ggagcatgca gcgaattcag     7080

aaagaggtct ttcagaagga aaccgaaact gacttgctca cctggaacac ctgatggtga     7140

aaccaaacaa atacaaaatc cttctccaga ccccagaact agaaaccccg ggccatccca     7200

ctagcagctt tggcctccat attgctctca tttcaagcag atctgctttt ctgcatgttt     7260

gtctgtgtgt ctgcgttgtg tgtgattttc atggaaaaat aaaatgcaaa tgcactcatc     7320

acaaacta                                                              7328


<210>  2
<211>  2273
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 


Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     


Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         


Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             


Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 


Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 


Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     


Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         


Asp Ile Glu Thr Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys 
        995                 1000                 1005             


Pro Gln  His Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His 
    1010                 1015                 1020             


Met Leu  Phe Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala 
    1025                 1030                 1035             


Gln Leu  Glu Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His 
    1040                 1045                 1050             


Lys Arg  Asn Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg 
    1055                 1060                 1065             


Lys Leu  Ser Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val 
    1070                 1075                 1080             


Ile Leu  Asp Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg 
    1085                 1090                 1095             


Ser Ile  Trp Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile 
    1100                 1105                 1110             


Ile Met  Ser Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp 
    1115                 1120                 1125             


Arg Ile  Ala Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr 
    1130                 1135                 1140             


Pro Leu  Phe Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr 
    1145                 1150                 1155             


Leu Val  Arg Lys Met Lys Asn  Ile Gln Ser Gln Arg  Lys Gly Ser 
    1160                 1165                 1170             


Glu Gly  Thr Cys Ser Cys Ser  Ser Lys Gly Phe Ser  Thr Thr Cys 
    1175                 1180                 1185             


Pro Ala  His Val Asp Asp Leu  Thr Pro Glu Gln Val  Leu Asp Gly 
    1190                 1195                 1200             


Asp Val  Asn Glu Leu Met Asp  Val Val Leu His His  Val Pro Glu 
    1205                 1210                 1215             


Ala Lys  Leu Val Glu Cys Ile  Gly Gln Glu Leu Ile  Phe Leu Leu 
    1220                 1225                 1230             


Pro Asn  Lys Asn Phe Lys His  Arg Ala Tyr Ala Ser  Leu Phe Arg 
    1235                 1240                 1245             


Glu Leu  Glu Glu Thr Leu Ala  Asp Leu Gly Leu Ser  Ser Phe Gly 
    1250                 1255                 1260             


Ile Ser  Asp Thr Pro Leu Glu  Glu Ile Phe Leu Lys  Val Thr Glu 
    1265                 1270                 1275             


Asp Ser  Asp Ser Gly Pro Leu  Phe Ala Gly Gly Ala  Gln Gln Lys 
    1280                 1285                 1290             


Arg Glu  Asn Val Asn Pro Arg  His Pro Cys Leu Gly  Pro Arg Glu 
    1295                 1300                 1305             


Lys Ala  Gly Gln Thr Pro Gln  Asp Ser Asn Val Cys  Ser Pro Gly 
    1310                 1315                 1320             


Ala Pro  Ala Ala His Pro Glu  Gly Gln Pro Pro Pro  Glu Pro Glu 
    1325                 1330                 1335             


Cys Pro  Gly Pro Gln Leu Asn  Thr Gly Thr Gln Leu  Val Leu Gln 
    1340                 1345                 1350             


His Val  Gln Ala Leu Leu Val  Lys Arg Phe Gln His  Thr Ile Arg 
    1355                 1360                 1365             


Ser His  Lys Asp Phe Leu Ala  Gln Ile Val Leu Pro  Ala Thr Phe 
    1370                 1375                 1380             


Val Phe  Leu Ala Leu Met Leu  Ser Ile Val Ile Pro  Pro Phe Gly 
    1385                 1390                 1395             


Glu Tyr  Pro Ala Leu Thr Leu  His Pro Trp Ile Tyr  Gly Gln Gln 
    1400                 1405                 1410             


Tyr Thr  Phe Phe Ser Met Asp  Glu Pro Gly Ser Glu  Gln Phe Thr 
    1415                 1420                 1425             


Val Leu  Ala Asp Val Leu Leu  Asn Lys Pro Gly Phe  Gly Asn Arg 
    1430                 1435                 1440             


Cys Leu  Lys Glu Gly Trp Leu  Pro Glu Tyr Pro Cys  Gly Asn Ser 
    1445                 1450                 1455             


Thr Pro  Trp Lys Thr Pro Ser  Val Ser Pro Asn Ile  Thr Gln Leu 
    1460                 1465                 1470             


Phe Gln  Lys Gln Lys Trp Thr  Gln Val Asn Pro Ser  Pro Ser Cys 
    1475                 1480                 1485             


Arg Cys  Ser Thr Arg Glu Lys  Leu Thr Met Leu Pro  Glu Cys Pro 
    1490                 1495                 1500             


Glu Gly  Ala Gly Gly Leu Pro  Pro Pro Gln Arg Thr  Gln Arg Ser 
    1505                 1510                 1515             


Thr Glu  Ile Leu Gln Asp Leu  Thr Asp Arg Asn Ile  Ser Asp Phe 
    1520                 1525                 1530             


Leu Val  Lys Thr Tyr Pro Ala  Leu Ile Arg Ser Ser  Leu Lys Ser 
    1535                 1540                 1545             


Lys Phe  Trp Val Asn Glu Gln  Arg Tyr Gly Gly Ile  Ser Ile Gly 
    1550                 1555                 1560             


Gly Lys  Leu Pro Val Val Pro  Ile Thr Gly Glu Ala  Leu Val Gly 
    1565                 1570                 1575             


Phe Leu  Ser Asp Leu Gly Arg  Ile Met Asn Val Ser  Gly Gly Pro 
    1580                 1585                 1590             


Ile Thr  Arg Glu Ala Ser Lys  Glu Ile Pro Asp Phe  Leu Lys His 
    1595                 1600                 1605             


Leu Glu  Thr Glu Asp Asn Ile  Lys Val Trp Phe Asn  Asn Lys Gly 
    1610                 1615                 1620             


Trp His  Ala Leu Val Ser Phe  Leu Asn Val Ala His  Asn Ala Ile 
    1625                 1630                 1635             


Leu Arg  Ala Ser Leu Pro Lys  Asp Arg Ser Pro Glu  Glu Tyr Gly 
    1640                 1645                 1650             


Ile Thr  Val Ile Ser Gln Pro  Leu Asn Leu Thr Lys  Glu Gln Leu 
    1655                 1660                 1665             


Ser Glu  Ile Thr Val Leu Thr  Thr Ser Val Asp Ala  Val Val Ala 
    1670                 1675                 1680             


Ile Cys  Val Ile Phe Ser Met  Ser Phe Val Pro Ala  Ser Phe Val 
    1685                 1690                 1695             


Leu Tyr  Leu Ile Gln Glu Arg  Val Asn Lys Ser Lys  His Leu Gln 
    1700                 1705                 1710             


Phe Ile  Ser Gly Val Ser Pro  Thr Thr Tyr Trp Val  Thr Asn Phe 
    1715                 1720                 1725             


Leu Trp  Asp Ile Met Asn Tyr  Ser Val Ser Ala Gly  Leu Val Val 
    1730                 1735                 1740             


Gly Ile  Phe Ile Gly Phe Gln  Lys Lys Ala Tyr Thr  Ser Pro Glu 
    1745                 1750                 1755             


Asn Leu  Pro Ala Leu Val Ala  Leu Leu Leu Leu Tyr  Gly Trp Ala 
    1760                 1765                 1770             


Val Ile  Pro Met Met Tyr Pro  Ala Ser Phe Leu Phe  Asp Val Pro 
    1775                 1780                 1785             


Ser Thr  Ala Tyr Val Ala Leu  Ser Cys Ala Asn Leu  Phe Ile Gly 
    1790                 1795                 1800             


Ile Asn  Ser Ser Ala Ile Thr  Phe Ile Leu Glu Leu  Phe Glu Asn 
    1805                 1810                 1815             


Asn Arg  Thr Leu Leu Arg Phe  Asn Ala Val Leu Arg  Lys Leu Leu 
    1820                 1825                 1830             


Ile Val  Phe Pro His Phe Cys  Leu Gly Arg Gly Leu  Ile Asp Leu 
    1835                 1840                 1845             


Ala Leu  Ser Gln Ala Val Thr  Asp Val Tyr Ala Arg  Phe Gly Glu 
    1850                 1855                 1860             


Glu His  Ser Ala Asn Pro Phe  His Trp Asp Leu Ile  Gly Lys Asn 
    1865                 1870                 1875             


Leu Phe  Ala Met Val Val Glu  Gly Val Val Tyr Phe  Leu Leu Thr 
    1880                 1885                 1890             


Leu Leu  Val Gln Arg His Phe  Phe Leu Ser Gln Trp  Ile Ala Glu 
    1895                 1900                 1905             


Pro Thr  Lys Glu Pro Ile Val  Asp Glu Asp Asp Asp  Val Ala Glu 
    1910                 1915                 1920             


Glu Arg  Gln Arg Ile Ile Thr  Gly Gly Asn Lys Thr  Asp Ile Leu 
    1925                 1930                 1935             


Arg Leu  His Glu Leu Thr Lys  Ile Tyr Pro Gly Thr  Ser Ser Pro 
    1940                 1945                 1950             


Ala Val  Asp Arg Leu Cys Val  Gly Val Arg Pro Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Thr Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Thr Thr  Val Thr Ser Gly Asp  Ala Thr Val 
    1985                 1990                 1995             


Ala Gly  Lys Ser Ile Leu Thr  Asn Ile Ser Glu Val  His Gln Asn 
    2000                 2005                 2010             


Met Gly  Tyr Cys Pro Gln Phe  Asp Ala Ile Asp Glu  Leu Leu Thr 
    2015                 2020                 2025             


Gly Arg  Glu His Leu Tyr Leu  Tyr Ala Arg Leu Arg  Gly Val Pro 
    2030                 2035                 2040             


Ala Glu  Glu Ile Glu Lys Val  Ala Asn Trp Ser Ile  Lys Ser Leu 
    2045                 2050                 2055             


Gly Leu  Thr Val Tyr Ala Asp  Cys Leu Ala Gly Thr  Tyr Ser Gly 
    2060                 2065                 2070             


Gly Asn  Lys Arg Lys Leu Ser  Thr Ala Ile Ala Leu  Ile Gly Cys 
    2075                 2080                 2085             


Pro Pro  Leu Val Leu Leu Asp  Glu Pro Thr Thr Gly  Met Asp Pro 
    2090                 2095                 2100             


Gln Ala  Arg Arg Met Leu Trp  Asn Val Ile Val Ser  Ile Ile Arg 
    2105                 2110                 2115             


Glu Gly  Arg Ala Val Val Leu  Thr Ser His Ser Met  Glu Glu Cys 
    2120                 2125                 2130             


Glu Ala  Leu Cys Thr Arg Leu  Ala Ile Met Val Lys  Gly Ala Phe 
    2135                 2140                 2145             


Arg Cys  Met Gly Thr Ile Gln  His Leu Lys Ser Lys  Phe Gly Asp 
    2150                 2155                 2160             


Gly Tyr  Ile Val Thr Met Lys  Ile Lys Ser Pro Lys  Asp Asp Leu 
    2165                 2170                 2175             


Leu Pro  Asp Leu Asn Pro Val  Glu Gln Phe Phe Gln  Gly Asn Phe 
    2180                 2185                 2190             


Pro Gly  Ser Val Gln Arg Glu  Arg His Tyr Asn Met  Leu Gln Phe 
    2195                 2200                 2205             


Gln Val  Ser Ser Ser Ser Leu  Ala Arg Ile Phe Gln  Leu Leu Leu 
    2210                 2215                 2220             


Ser His  Lys Asp Ser Leu Leu  Ile Glu Glu Tyr Ser  Val Thr Gln 
    2225                 2230                 2235             


Thr Thr  Leu Asp Gln Val Phe  Val Asn Phe Ala Lys  Gln Gln Thr 
    2240                 2245                 2250             


Glu Ser  His Asp Leu Pro Leu  His Pro Arg Ala Ala  Gly Ala Ser 
    2255                 2260                 2265             


Arg Gln  Ala Gln Asp 
    2270             


<210>  3
<211>  3816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc gctctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg      780

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg      840

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg      900

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg      960

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     1020

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     1080

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     1140

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     1200

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     1260

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     1320

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     1380

gtatgcgtga agaatctggt aaagattttt gagccctgtg gccggccagc tgtggaccgt     1440

ctgaacatca ccttctacga gaaccagatc accgcattcc tgggccacaa tggagctggg     1500

aaaaccacca ccttgtccat cctgacgggt ctgttgccac caacctctgg gactgtgctc     1560

gttgggggaa gggacattga aaccagcctg gatgcagtcc ggcagagcct tggcatgtgt     1620

ccacagcaca acatcctgtt ccaccacctc acggtggctg agcacatgct gttctatgcc     1680

cagctgaaag gaaagtccca ggaggaggcc cagctggaga tggaagccat gttggaggac     1740

acaggcctcc accacaagcg gaatgaagag gctcaggacc tatcaggtgg catgcagaga     1800

aagctgtcgg ttgccattgc ctttgtggga gatgccaagg tggtgattct ggacgaaccc     1860

acctctgggg tggaccctta ctcgagacgc tcaatctggg atctgctcct gaagtatcgc     1920

tcaggcagaa ccatcatcat gtccactcac cacatggacg aggccgacct ccttggggac     1980

cgcattgcca tcattgccca gggaaggctc tactgctcag gcaccccact cttcctgaag     2040

aactgctttg gcacaggctt gtacttaacc ttggtgggcg aataccccgc tttgaccctt     2100

cacccctgga tatatgggca gcagtacacc ttcttcagca tggatgaacc aggcagtgag     2160

cagttcacgg tacttgcaga cgtcctcctg aataagccag gctttggcaa ccgctgcctg     2220

aaggaagggt ggcttccgga gtacccctgt ggcaactcaa caccctggaa gactccttct     2280

gtgtccccaa acatcaccca gctgttccag aagcagaaat ggacacaggt caacccttca     2340

ccatcctgca ggtgcagcac cagggagaag ctcaccatgc tgccagagtg ccccgagggt     2400

gccgggggcc tcccgccccc ccagagaaca cagcgcagca cggaaattct acaagacctg     2460

acggacagga acatctccga cttcttggta aaaacgtatc ctgctcttat aagaagcagc     2520

ttaaagagca aattctgggt caatgaacag aggtatggag gaatttccat tggaggaaag     2580

ctcccagtcg tccccatcac gggggaagca cttgttgggt ttttaagcga ccttggccgg     2640

atcatgaatg tgagcggggg ccctatcact agagaggcct ctaaagaaat acctgatttc     2700

cttaaacatc tagaaactga agacaacatt aaggtgtggt ttaataacaa aggctggcat     2760

gccctggtca gctttctcaa tgtggcccac aacgccatct tacggttaag gctacatgaa     2820

ctaaccaaga tttatccagg cacctccagc ccagcagtgg acaggctgtg tgtcggagtt     2880

cgccctggag agtgctttgg cctcctggga gtgaatggtg ccggcaaaac aaccacattc     2940

aagatgctca ctggggacac cacagtgacc tcaggggatg ccaccgtagc aggcaagagt     3000

attttaacca atatttctga agtccatcaa aatatgggct actgtcctca gtttgatgca     3060

attgatgagc tgctcacagg acgagaacat ctttaccttt atgcccggct tcgaggtgta     3120

ccagcagaag aaatcgaaaa ggttgcaaac tggagtatta agagcctggg cctgactgtc     3180

tacgccgact gcctggctgg cacgtacagt gggggcaaca agcggaaact ctccacagcc     3240

atcgcactca ttggctgccc accgctggtg ctgctggatg agcccaccac agggatggac     3300

ccccaggcac gccgcatgct gtggaacgtc atcgtgagca tcatcagaga agggagggct     3360

gtggtcctca catcccacag catggaagaa tgtgaggcac tgtgtacccg gctggccatc     3420

atggtaaagg gcgcctttcg atgtatgggc accattcagc atctcaagtc caaatttgga     3480

gatggctata tcgtcacaat gaagatcaaa tccccgaagg acgacctgct tcctgacctg     3540

aaccctgtgg agcagttctt ccaggggaac ttcccaggca gtgtgcagag ggagaggcac     3600

tacaacatgc tccagttcca ggtctcctcc tcctccctgg cgaggatctt ccagctcctc     3660

ctctcccaca aggacagcct gctcatcgag gagtactcag tcacacagac cacactggac     3720

caggtgtttg taaattttgc taaacagcag actgaaagtc atgacctccc tctgcaccct     3780

cgagctgctg gagccagtcg acaagcccag gactga                               3816


<210>  4
<211>  3804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc gctctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtatgtatg cgtgaagaat ctggtaaaga tttttgagcc ctgtggccgg      780

ccagctgtgg accgtctgaa catcaccttc tacgagaacc agatcaccgc attcctgggc      840

cacaatggag ctgggaaaac caccaccttg tccatcctga cgggtctgtt gccaccaacc      900

tctgggactg tgctcgttgg gggaagggac attgaaacca gcctggatgc agtccggcag      960

agccttggca tgtgtccaca gcacaacatc ctgttccacc acctcacggt ggctgagcac     1020

atgctgttct atgcccagct gaaaggaaag tcccaggagg aggcccagct ggagatggaa     1080

gccatgttgg aggacacagg cctccaccac aagcggaatg aagaggctca ggacctatca     1140

ggtggcatgc agagaaagct gtcggttgcc attgcctttg tgggagatgc caaggtggtg     1200

attctggacg aacccacctc tggggtggac ccttactcga gacgctcaat ctgggatctg     1260

ctcctgaagt atcgctcagg cagaaccatc atcatgtcca ctcaccacat ggacgaggcc     1320

gacctccttg gggaccgcat tgccatcatt gcccagggaa ggctctactg ctcaggcacc     1380

ccactcttcc tgaagaactg ctttggcaca ggcttgtact taaccttggt gggcgaatac     1440

cccgctttga cccttcaccc ctggatatat gggcagcagt acaccttctt cagcatggat     1500

gaaccaggca gtgagcagtt cacggtactt gcagacgtcc tcctgaataa gccaggcttt     1560

ggcaaccgct gcctgaagga agggtggctt ccggagtacc cctgtggcaa ctcaacaccc     1620

tggaagactc cttctgtgtc cccaaacatc acccagctgt tccagaagca gaaatggaca     1680

caggtcaacc cttcaccatc ctgcaggtgc agcaccaggg agaagctcac catgctgcca     1740

gagtgccccg agggtgccgg gggcctcccg cccccccaga gaacacagcg cagcacggaa     1800

attctacaag acctgacgga caggaacatc tccgacttct tggtaaaaac gtatcctgct     1860

cttataagaa gcagcttaaa gagcaaattc tgggtcaatg aacagaggta tggaggaatt     1920

tccattggag gaaagctccc agtcgtcccc atcacggggg aagcacttgt tgggttttta     1980

agcgaccttg gccggatcat gaatgtgagc gggggcccta tcactagaga ggcctctaaa     2040

gaaatacctg atttccttaa acatctagaa actgaagaca acattaaggt gtggtttaat     2100

aacaaaggct ggcatgccct ggtcagcttt ctcaatgtgg cccacaacgc catcttacgg     2160

aacttcctct gggacatcat gaattattcc gtgagtgctg ggctggtggt gggcatcttc     2220

atcgggtttc agaagaaagc ctacacttct ccagaaaacc ttcctgccct tgtggcactg     2280

ctcctgctgt atggatgggc ggtcattccc atgatgtacc cagcatcctt cctgtttgat     2340

gtccccagca cagcctatgt ggctttatct tgtgctaatc tgttcatcgg catcaacagc     2400

agtgctatta ccttcatctt ggaattattt gagaataacc ggacgctgct caggttcaac     2460

gccgtgctga ggaagctgct cattgtcttc ccccacttct gcctgggccg gggcctcatt     2520

gaccttgcac tgagccaggc tgtgacagat gtctatgccc ggtttggtga ggagcactct     2580

gcaaatccgt tccactggga cctgattggg aagaacctgt ttgccatggt ggtggaaggg     2640

gtggtgtact tcctcctgac cctgctggtc cagcgccact tcttcctctc ccaatggatt     2700

gccgagccca ctaaggagcc cattgttgat gaagatgatg atgtggctga agaaagacaa     2760

agaattatta ctggtggaaa taaaactgac atcttaaggc tacatgaact aaccaagatt     2820

tatccaggca cctccagccc agcagtggac aggctgtgtg tcggagttcg ccctggagag     2880

tgctttggcc tcctgggagt gaatggtgcc ggcaaaacaa ccacattcaa gatgctcact     2940

ggggacacca cagtgacctc aggggatgcc accgtagcag gcaagagtat tttaaccaat     3000

atttctgaag tccatcaaaa tatgggctac tgtcctcagt ttgatgcaat tgatgagctg     3060

ctcacaggac gagaacatct ttacctttat gcccggcttc gaggtgtacc agcagaagaa     3120

atcgaaaagg ttgcaaactg gagtattaag agcctgggcc tgactgtcta cgccgactgc     3180

ctggctggca cgtacagtgg gggcaacaag cggaaactct ccacagccat cgcactcatt     3240

ggctgcccac cgctggtgct gctggatgag cccaccacag ggatggaccc ccaggcacgc     3300

cgcatgctgt ggaacgtcat cgtgagcatc atcagagaag ggagggctgt ggtcctcaca     3360

tcccacagca tggaagaatg tgaggcactg tgtacccggc tggccatcat ggtaaagggc     3420

gcctttcgat gtatgggcac cattcagcat ctcaagtcca aatttggaga tggctatatc     3480

gtcacaatga agatcaaatc cccgaaggac gacctgcttc ctgacctgaa ccctgtggag     3540

cagttcttcc aggggaactt cccaggcagt gtgcagaggg agaggcacta caacatgctc     3600

cagttccagg tctcctcctc ctccctggcg aggatcttcc agctcctcct ctcccacaag     3660

gacagcctgc tcatcgagga gtactcagtc acacagacca cactggacca ggtgtttgta     3720

aattttgcta aacagcagac tgaaagtcat gacctccctc tgcaccctcg agctgctgga     3780

gccagtcgac aagcccagga ctga                                            3804


<210>  5
<211>  4062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc gctctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct tcccacactc      780

ctagacagcc gttctcaagg tatcaatctg agatcttggg gaggaatatt atctgatatg      840

tcaccaagaa ttcaagagtt tatccatcgg ccgagtatgc aggacttgct gtgggtgacc      900

aggcccctca tgcagaatgg tggtccagag acctttacaa agctgatggg catcctgtct      960

gacctcctgt gtggctaccc cgagggaggt ggctctcggg tgctctcctt caactggtat     1020

gaagacaata actataaggc ctttctgggg attgactcca caaggaagga tcctatctat     1080

tcttatgaca gaagaacaac atccttttgt aatgcattga tccagagcct ggagtcaaat     1140

cctttaacca aaatcgcttg gagggcggca aagcctttgc tgatgggaaa aatcctgtac     1200

actcctgatt cacctgcagc acgaaggata ctgaagaatg ccaactcaac ttttgaagaa     1260

ctggaacacg ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca gatctggtac     1320

ttctttgaca acagcacaca gatgaacatg atcagagata ccctggggaa cccaacagta     1380

aaagactttt tgaataggca gcttggtgaa gaaggtatta ctgctgaagc catcctaaac     1440

ttcctctaca agggccctcg ggaaagccag gctgacgaca tggccaactt cgactggagg     1500

gacatattta acatcactga tcgcaccctc cgcctggtca atcaatacct ggagtgcttg     1560

gtcctggata agtttgaaag ctacaatgat gaaactcagc tcacccaacg tgccctctct     1620

ctactggagg aaaacatgtt ctgggccgga gtggtattcc ctgacatgta tccctggacc     1680

agctctctac caccccacgt gaagtataag atccgaatgg acatagacgt ggtggagaaa     1740

accaataaga ttaaagacag gtattgggat tctggtccca gagctgatcc cgtggaagat     1800

ttccggtaca tctggggcgg gtttgcctat ctgcaggaca tggttgaaca ggggatcaca     1860

aggagccagg tgcaggcgga ggctccagtt ggaatctacc tccagcagat gccctacccc     1920

tgcttcgtgg acgattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg     1980

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg     2040

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg     2100

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg     2160

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     2220

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     2280

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     2340

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     2400

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     2460

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     2520

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     2580

ctaacagagg aaacggagga tccagagcac ccagaaggaa tacacgactc cttctttgaa     2640

cgtgagcatc cagggtgggt tcctggggta tgcgtgaaga atctggtaaa gatttttgag     2700

ccctgtggcc ggccagctgt ggaccgtctg aacatcacct tctacgagaa ccagatcacc     2760

gcattcctgg gccacaatgg agctgggaaa accaccacct tgtccatcct gacgggtctg     2820

ttgccaccaa cctctgggac tgtgctcgtt gggggaaggg acattgaaac cagcctggat     2880

gcaggcgaat accccgcttt gacccttcac ccctggatat atgggcagca gtacaccttc     2940

ttcagcatgg atgaaccagg cagtgagcag ttcacggtac ttgcagacgt cctcctgaat     3000

aagccaggct ttggcaaccg ctgcctgaag gaagggtggc ttccggagta cccctgtggc     3060

aactcaacac cctggaagac tccttctgtg tccccaaaca tcacccagct gttccagaag     3120

cagaaatgga cacaggtcaa cccttcacca tcctgcaggt gcagcaccag ggagaagctc     3180

accatgctgc cattaaggct acatgaacta accaagattt atccaggcac ctccagccca     3240

gcagtggaca ggctgtgtgt cggagttcgc cctggagagt gctttggcct cctgggagtg     3300

aatggtgccg gcaaaacaac cacattcaag atgctcactg gggacaccac agtgacctca     3360

ggggatgcca ccgtagcagg caagagtatt ttaaccaata tttctgaagt ccatcaaaat     3420

atgggctact gtcctcagtt tgatgcaatt gatgagctgc tcacaggacg agaacatctt     3480

tacctttatg cccggcttcg aggtgtacca gcagaagaaa tcgaaaaggt tgcaaactgg     3540

agtattaaga gcctgggcct gactgtctac gccgactgcc tggctggcac gtacagtggg     3600

ggcaacaagc ggaaactctc cacagccatc gcactcattg gctgcccacc gctggtgctg     3660

ctggatgagc ccaccacagg gatggacccc caggcacgcc gcatgctgtg gaacgtcatc     3720

gtgagcatca tcagagaagg gagggctgtg gtcctcacat cccacagcat ggaagaatgt     3780

gaggcactgt gtacccggct ggccatcatg gtaaagggcg cctttcgatg tatgggcacc     3840

attcagcatc tcaagtccaa atttggagat ggctatatcg tcacaatgaa gatcaaatcc     3900

ccgaaggacg acctgcttcc tgacctgaac cctgtggagc agttcttcca ggggaacttc     3960

ccaggcagtg tgcagaggga gaggcactac aacatgctcc agttccaggt ctcctcctcc     4020

tccctggcga ggatcttcca ggtgtttgta aattttgctt ga                        4062


<210>  6
<211>  3669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc gctctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct tcccacactc      780

ctagacagcc gttctcaagg tatcaatctg agatcttggg gaggaatatt atctgatatg      840

tcaccaagaa ttcaagagtt tatccatcgg ccgagtatgc aggacttgct gtgggtgacc      900

aggcccctca tgcagaatgg tggtccagag acctttacaa agctgatggg catcctgtct      960

gacctcctgt gtggctaccc cgagggaggt ggctctcggg tgctctcctt caactggtat     1020

gaagacaata actataaggc ctttctgggg attgactcca caaggaagga tcctatctat     1080

tcttatgaca gaagaacaac atccttttgt aatgcattga tccagagcct ggagtcaaat     1140

cctttaacca aaatcgcttg gagggcggca aagcctttgc tgatgggaaa aatcctgtac     1200

actcctgatt cacctgcagc acgaaggata ctgaagaatg ccaactcaac ttttgaagaa     1260

ctggaacacg ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca gatctggtac     1320

ttctttgaca acagcacaca gatgaacatg atcagagata ccctggggaa cccaacagta     1380

aaagactttt tgaataggca gcttggtgaa gaaggtatta ctgctgaagc catcctaaac     1440

ttcctctaca agggccctcg ggaaagccag gctgacgaca tggccaactt cgactggagg     1500

gacatattta acatcactga tcgcaccctc cgcctggtca atcaatacct ggagtgcttg     1560

gtcctggata agtttgaaag ctacaatgat gaaactcagc tcacccaacg tgccctctct     1620

ctactggagg aaaacatgtt ctgggccgga gtggtattcc ctgacatgta tccctggacc     1680

agctctctac caccccacgt gaagtataag atccgaatgg acatagacgt ggtggagaaa     1740

accaataaga ttaaagacag gtattgggat tctggtccca gagctgatcc cgtggaagat     1800

ttccggtaca tctggggcgg gtttgcctat ctgcaggaca tggttgaaca ggggatcaca     1860

aggagccagg tgcaggcgga ggctccagtt ggaatctacc tccagcagat gccctacccc     1920

tgcttcgtgg acgattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg     1980

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg     2040

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg     2100

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg     2160

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     2220

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     2280

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     2340

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     2400

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     2460

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     2520

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     2580

gtccggcaga gccttggcat gtgtccacag cacaacatcc tgttccacca cctcacggtg     2640

gctgagcaca tgctgttcta tgcccagctg aaaggaaagt cccaggagga ggcccagctg     2700

gagatggaag ccatgttgga ggacacaggc ctccaccaca agcggaatga agaggctcag     2760

gacctatcag gtggcatgca gagaaagctg tcggttgcca ttgcctttgt gggagatgcc     2820

aaggtggtga ttctggacga acccacctct ggggtggacc cttactcgag acgctcaatc     2880

tgggatctgc tcctgaagta tcgctcaggc agaaccatca tcatgtccac tcaccacatg     2940

gacgaggccg acctccttgg ggaccgcatt gccatcattg cccagggaag gctctactgc     3000

tcaggcaccc cactcttcct gaagaactgc tttggcacag gcttgtactt aaccttggtg     3060

ggcgaatacc ccgctttgac ccttcacccc tggatatatg ggcagcagta caccttcttc     3120

agcatggatg aaccaggcag tgagcagttc acggtacttg cagacgtcct cctgaataag     3180

ccaggctttg gcaaccgctg cctgaaggaa gggtggcttc cggagtaccc ctgtggcaac     3240

tcaacaccct ggaagactcc ttctgtgtcc ccaaacatca cccagctgtt ccagaagcag     3300

aaatggacac aggtcaaccc ttcaccatcc tgcaggtgca gcaccaggga gaagctcacc     3360

atgctgccat taaggctaca tgaactaacc aagatttatc caggcacctc cagcccagca     3420

gtggacaggc tgtgtgtcgg agttcgccct ggagagtgct ttggcctcct gggagtgaat     3480

ggtgccggca aaacaaccac attcaagatg ctcactgggg acaccacagt gacctcaggg     3540

gatgccaccg tagcaggcat caaatccccg aaggacgacc tgcttcctga cctgaaccct     3600

gtggagcagt tcttccaggg gaacttccca ggcagtgtgc agagggaggt gtttgtaaat     3660

tttgcttga                                                             3669


<210>  7
<211>  3069
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc gctctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg      780

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg      840

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg      900

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg      960

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     1020

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     1080

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     1140

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     1200

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     1260

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     1320

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     1380

ctaacagagg aaacggagga tccagagcac ccagaaggaa tacacgactc cttctttgaa     1440

cgtgagcatc cagggtgggt tcctggggta tgcgtgaaga atctggtaaa gatttttgag     1500

ccctgtggcc ggccagctgt ggaccgtctg aacatcacct tctacgagaa ccagatcacc     1560

gcattcctgg gccacaatgg agctgggaaa accaccacct tgtccatcct gacgggtctg     1620

ttgccaccaa cctctgggac tgtgctcgtt gggggaaggg acattgaaac cagcctggat     1680

gcacacaagg acttcctggc gcagatcgtg ctcccggcta cctttgtgtt tttggctctg     1740

atgctttcta ttgttatccc tccttttggc gaataccccg ctttgaccct tcacccctgg     1800

atatatgggc agcagtacac cttcttcagc atggatgaac caggcagtga gcagttcacg     1860

gtacttgcag acgtcctcct gaataagcca ggctttggca accgctgcct gaaggaaggg     1920

tggcttccgg agtacccctg tggcaactca acaccctgga agactccttc tgtgtcccca     1980

aacatcaccc agctgttcca gaagcagaaa tggacacagg tcaacccttc accatcctgc     2040

aggtgcagca ccagggagaa gctcaccatg ctgccaaact tcctctggga catcatgaat     2100

tattccgtga gtgctgggct ggtggtgggc atcttcatcg ggtttcagaa gaaagcctac     2160

acttctccag aaaaccttcc tgcccttgtg gcactgctcc tgctgtatgg atgggcggtc     2220

attcccatga tgtacccagc atccttcctg tttgatgtcc ccagcacagc ctatgtggct     2280

ttatcttgtg ctaatctgtt catcggcatc aacagcagtg ctattacctt catcttggaa     2340

ttatttgaga ataaccggac gctgctcagg ttcaacgccg tgctgaggaa gctgctcatt     2400

gtcttccccc acttctgcct gggccggggc ctcattgacc ttgcactgag ccaggctgtg     2460

acagatgtct atgcccggtt tggtgaggag cactctgcaa atccgttcca ctgggacctg     2520

attgggaaga acctgtttgc catggtggtg gaaggggtgg tgtacttcct cctgaccctg     2580

ctggtccagc gccacttctt cctctcccaa tggattgccg agcccactaa ggagcccatt     2640

gttgatgaag atgatgatgt ggctgaagaa agacaaagaa ttattactgg tggaaataaa     2700

actgacatct taaggctaca tgaactaacc aagatttatc caggcacctc cagcccagca     2760

gtggacaggc tgtgtgtcgg agttcgccct ggagagtgct ttggcctcct gggagtgaat     2820

ggtgccggca aaacaaccac attcaagatg ctcactgggg acaccacagt gacctcaggg     2880

gatgccaccg tagcaggcat caaatccccg aaggacgacc tgcttcctga cctgaaccct     2940

gtggagcagt tcttccaggg gaacttccca ggcagtgtgc agagggagag gcactacaac     3000

atgctccagt tccaggtctc ctcctcctcc ctggcgagga tcttccaggt gtttgtaaat     3060

tttgcttga                                                             3069


<210>  8
<211>  4401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaaggg ccaacgtgga cttcttcaag ctcttccgtg tgcttcccac actcctagac      180

agccgttctc aaggtatcaa tctgagatct tggggaggaa tattatctga tatgtcacca      240

agaattcaag agtttatcca tcggccgagt atgcaggact tgctgtgggt gaccaggccc      300

ctcatgcaga atggtggtcc agagaccttt acaaagctga tgggcatcct gtctgacctc      360

ctgtgtggct accccgaggg aggtggctct cgggtgctct ccttcaactg gtatgaagac      420

aataactata aggcctttct ggggattgac tccacaagga aggatcctat ctattcttat      480

gacagaagaa caacatcctt ttgtaatgca ttgatccaga gcctggagtc aaatccttta      540

accaaaatcg cttggagggc ggcaaagcct ttgctgatgg gaaaaatcct gtacactcct      600

gattcacctg cagcacgaag gatactgaag aatgccaact caacttttga agaactggaa      660

cacgttagga agttggtcaa agcctgggaa gaagtagggc cccagatctg gtacttcttt      720

gacaacagca cacagatgaa catgatcaga gataccctgg ggaacccaac agtaaaagac      780

tttttgaata ggcagcttgg tgaagaaggt attactgctg aagccatcct aaacttcctc      840

tacaagggcc ctcgggaaag ccaggctgac gacatggcca acttcgactg gagggacata      900

tttaacatca ctgatcgcac cctccgcctg gtcaatcaat acctggagtg cttggtcctg      960

gataagtttg aaagctacaa tgatgaaact cagctcaccc aacgtgccct ctctctactg     1020

gaggaaaaca tgttctgggc cggagtggta ttccctgaca tgtatccctg gaccagctct     1080

ctaccacccc acgtgaagta taagatccga atggacatag acgtggtgga gaaaaccaat     1140

aagattaaag acaggtattg ggattctggt cccagagctg atcccgtgga agatttccgg     1200

tacatctggg gcgggtttgc ctatctgcag gacatggttg aacaggggat cacaaggagc     1260

caggtgcagg cggaggctcc agttggaatc tacctccagc agatgcccta cccctgcttc     1320

gtggacgatt ctttcatgat catcctgaac cgctgtttcc ctatcttcat ggtgctggca     1380

tggatctact ctgtctccat gactgtgaag agcatcgtct tggagaagga gttgcgactg     1440

aaggagacct tgaaaaatca gggtgtctcc aatgcagtga tttggtgtac ctggttcctg     1500

gacagcttct ccatcatgtc gatgagcatc ttcctcctga cgatattcat catgcatgga     1560

agaatcctac attacagcga cccattcatc ctcttcctgt tcttgttggc tttctccact     1620

gccaccatca tgctgtgctt tctgctcagc accttcttct ccaaggccag tctggcagca     1680

gcctgtagtg gtgtcatcta tttcaccctc tacctgccac acatcctgtg cttcgcctgg     1740

caggaccgca tgaccgctga gctgaagaag gctgtgagct tactgtctcc ggtggcattt     1800

ggatttggca ctgagtacct ggttcgcttt gaagagcaag gcctggggct gcagtggagc     1860

aacatcggga acagtcccac ggaaggggac gaattcagct tcctgctgtc catgcagatg     1920

atgctccttg atgctgctgt ctatggctta ctcgcttggt accttgatca ggtggtccgg     1980

cagagccttg gcatgtgtcc acagcacaac atcctgttcc accacctcac ggtggctgag     2040

cacatgctgt tctatgccca gctgaaagga aagtcccagg aggaggccca gctggagatg     2100

gaagccatgt tggaggacac aggcctccac cacaagcgga atgaagaggc tcaggaccta     2160

tcaggtggca tgcagagaaa gctgtcggtt gccattgcct ttgtgggaga tgccaaggtg     2220

gtgattctgg acgaacccac ctctggggtg gacccttact cgagacgctc aatctgggat     2280

ctgctcctga agtatcgctc aggcagaacc atcatcatgt ccactcacca catggacgag     2340

gccgacctcc ttggggaccg cattgccatc attgcccagg gaaggctcta ctgctcaggc     2400

accccactct tcctgaagaa ctgctttggc acaggcttgt acttaacctt ggtgcgcaag     2460

atgaaaaaca tccagagcca aaggaaaggc agtgagggga cctgcagctg ctcgtctaag     2520

ggtttctcca ccacgtgtcc agcccacgtc gatgacctaa ctccagaaca agtccacaag     2580

gacttcctgg cgcagatcgt gctcccggct acctttgtgt ttttggctct gatgctttct     2640

attgagtgcc ccgagggtgc cgggggcctc ccgccccccc agagaacaca gcgcagcacg     2700

gaaattctac aagacctgac ggacaggaac atctccgact tcttggtaaa aacgtatcct     2760

gctcttataa gaagcagctt aaagagcaaa ttctgggtca atgaacagag gtatggagga     2820

atttccattg gaggaaagct cccagtcgtc cccatcacgg gggaagcact tgttgggttt     2880

ttaagcgacc ttggccggat catgaatgtg agcgggggcc ctatcactag agaggcctct     2940

aaagaaatac ctgatttcct taaacatcta gaaactgaag acaacattaa ggtgtggttt     3000

aataacaaag gctggcatgc cctggtcagc tttctcaatg tggcccacaa cgccatctta     3060

cgggccagcc tgcctaagga caggagcccc gagaacttcc tctgggacat catgaattat     3120

tccgtgagtg ctgggctggt ggtgggcatc ttcatcgggt ttcagaagaa agcctacact     3180

tctccagaaa accttcctgc ccttgtggca ctgctcctgc tgtatggatg ggcggtcatt     3240

cccatgatgt acccagcatc cttcctgttt gatgtcccca gcacagccta tgtggcttta     3300

tcttgtgcta atctgttcat cggcatcaac agcagtgcta ttaccttcat cttggaatta     3360

tttgagaata accggacgct gctcaggttc aacgccgtgc tgaggaagct gctcattgtc     3420

ttcccccact tctgcctggg ccggggcctc attgaccttg cactgagcca ggctgtgaca     3480

gatgtctatg cccggtttgg tgaggagcac tctgcaaatc cgttccactg ggacctgatt     3540

gggaagaacc tgtttgccat ggtggtggaa ggggtggtgt acttcctcct gaccctgctg     3600

gtccagcgcc acttcttcct ctcccaatgg attgccgagc ccactaagga gcccattgtt     3660

gatgaagatg atgatgtggc tgaagaaaga caaagaatta ttactggtgg aaataaaact     3720

gacatcttaa agagtatttt aaccaatatt tctgaagtcc atcaaaatat gggctactgt     3780

cctcagtttg atgcaattga tgagctgctc acaggacgag aacatcttta cctttatgcc     3840

cggcttcgag gtgtaccagc agaagaaatc gaaaaggttg caaactggag tattaagagc     3900

ctgggcctga ctgtctacgc cgactgcctg gctggcacgt acagtggggg caacaagcgg     3960

aaactctcca cagccatcgc actcattggc tgcccaccgc tggtgctgct ggatgagccc     4020

accacaggga tggaccccca ggcacgccgc atgctgtgga acgtcatcgt gagcatcatc     4080

agagaaggga gggctgtggt cctcacatcc cacagcatgg aagaatgtga ggcactgtgt     4140

acccggctgg ccatcatggt aaagggcgcc tttcgatgta tgggcaccat tcagcatctc     4200

aagtccaaat ttggagatgg ctatatcgtc acaatgaagc tcctcctctc ccacaaggac     4260

agcctgctca tcgaggagta ctcagtcaca cagaccacac tggaccaggt gtttgtaaat     4320

tttgctaaac agcagactga aagtcatgac ctccctctgc accctcgagc tgctggagcc     4380

agtcgacaag cccaggactg a                                               4401


<210>  9
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                245                 250                 255     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            260                 265                 270         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        275                 280                 285             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    290                 295                 300                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
305                 310                 315                 320 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                325                 330                 335     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            340                 345                 350         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        355                 360                 365             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    370                 375                 380                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
385                 390                 395                 400 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                405                 410                 415     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            420                 425                 430         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        435                 440                 445             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Val Cys Val Lys 
    450                 455                 460                 


Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro Ala Val Asp Arg 
465                 470                 475                 480 


Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala Phe Leu Gly His 
                485                 490                 495     


Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu Thr Gly Leu Leu 
            500                 505                 510         


Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg Asp Ile Glu Thr 
        515                 520                 525             


Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys Pro Gln His Asn 
    530                 535                 540                 


Ile Leu Phe His His Leu Thr Val Ala Glu His Met Leu Phe Tyr Ala 
545                 550                 555                 560 


Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu Glu Met Glu Ala 
                565                 570                 575     


Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn Glu Glu Ala Gln 
            580                 585                 590         


Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val Ala Ile Ala Phe 
        595                 600                 605             


Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro Thr Ser Gly Val 
    610                 615                 620                 


Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu Leu Lys Tyr Arg 
625                 630                 635                 640 


Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met Asp Glu Ala Asp 
                645                 650                 655     


Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly Arg Leu Tyr Cys 
            660                 665                 670         


Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly Thr Gly Leu Tyr 
        675                 680                 685             


Leu Thr Leu Val Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile 
    690                 695                 700                 


Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu 
705                 710                 715                 720 


Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe Gly 
                725                 730                 735     


Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn 
            740                 745                 750         


Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu 
        755                 760                 765             


Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys Arg 
    770                 775                 780                 


Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu Gly 
785                 790                 795                 800 


Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile 
                805                 810                 815     


Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys Thr 
            820                 825                 830         


Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val Asn 
        835                 840                 845             


Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val Val 
    850                 855                 860                 


Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly Arg 
865                 870                 875                 880 


Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu 
                885                 890                 895     


Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys Val 
            900                 905                 910         


Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn Val 
        915                 920                 925             


Ala His Asn Ala Ile Leu Arg Leu Arg Leu His Glu Leu Thr Lys Ile 
    930                 935                 940                 


Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val 
945                 950                 955                 960 


Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys 
                965                 970                 975     


Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly 
            980                 985                 990         


Asp Ala Thr Val Ala Gly Lys Ser  Ile Leu Thr Asn Ile  Ser Glu Val 
        995                 1000                 1005             


His Gln  Asn Met Gly Tyr Cys  Pro Gln Phe Asp Ala  Ile Asp Glu 
    1010                 1015                 1020             


Leu Leu  Thr Gly Arg Glu His  Leu Tyr Leu Tyr Ala  Arg Leu Arg 
    1025                 1030                 1035             


Gly Val  Pro Ala Glu Glu Ile  Glu Lys Val Ala Asn  Trp Ser Ile 
    1040                 1045                 1050             


Lys Ser  Leu Gly Leu Thr Val  Tyr Ala Asp Cys Leu  Ala Gly Thr 
    1055                 1060                 1065             


Tyr Ser  Gly Gly Asn Lys Arg  Lys Leu Ser Thr Ala  Ile Ala Leu 
    1070                 1075                 1080             


Ile Gly  Cys Pro Pro Leu Val  Leu Leu Asp Glu Pro  Thr Thr Gly 
    1085                 1090                 1095             


Met Asp  Pro Gln Ala Arg Arg  Met Leu Trp Asn Val  Ile Val Ser 
    1100                 1105                 1110             


Ile Ile  Arg Glu Gly Arg Ala  Val Val Leu Thr Ser  His Ser Met 
    1115                 1120                 1125             


Glu Glu  Cys Glu Ala Leu Cys  Thr Arg Leu Ala Ile  Met Val Lys 
    1130                 1135                 1140             


Gly Ala  Phe Arg Cys Met Gly  Thr Ile Gln His Leu  Lys Ser Lys 
    1145                 1150                 1155             


Phe Gly  Asp Gly Tyr Ile Val  Thr Met Lys Ile Lys  Ser Pro Lys 
    1160                 1165                 1170             


Asp Asp  Leu Leu Pro Asp Leu  Asn Pro Val Glu Gln  Phe Phe Gln 
    1175                 1180                 1185             


Gly Asn  Phe Pro Gly Ser Val  Gln Arg Glu Arg His  Tyr Asn Met 
    1190                 1195                 1200             


Leu Gln  Phe Gln Val Ser Ser  Ser Ser Leu Ala Arg  Ile Phe Gln 
    1205                 1210                 1215             


Leu Leu  Leu Ser His Lys Asp  Ser Leu Leu Ile Glu  Glu Tyr Ser 
    1220                 1225                 1230             


Val Thr  Gln Thr Thr Leu Asp  Gln Val Phe Val Asn  Phe Ala Lys 
    1235                 1240                 1245             


Gln Gln  Thr Glu Ser His Asp  Leu Pro Leu His Pro  Arg Ala Ala 
    1250                 1255                 1260             


Gly Ala  Ser Arg Gln Ala Gln  Asp 
    1265                 1270     


<210>  10
<211>  1267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu 
                245                 250                 255     


Pro Cys Gly Arg Pro Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu 
            260                 265                 270         


Asn Gln Ile Thr Ala Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr 
        275                 280                 285             


Thr Leu Ser Ile Leu Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val 
    290                 295                 300                 


Leu Val Gly Gly Arg Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln 
305                 310                 315                 320 


Ser Leu Gly Met Cys Pro Gln His Asn Ile Leu Phe His His Leu Thr 
                325                 330                 335     


Val Ala Glu His Met Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln 
            340                 345                 350         


Glu Glu Ala Gln Leu Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu 
        355                 360                 365             


His His Lys Arg Asn Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln 
    370                 375                 380                 


Arg Lys Leu Ser Val Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val 
385                 390                 395                 400 


Ile Leu Asp Glu Pro Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser 
                405                 410                 415     


Ile Trp Asp Leu Leu Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met 
            420                 425                 430         


Ser Thr His His Met Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala 
        435                 440                 445             


Ile Ile Ala Gln Gly Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu 
    450                 455                 460                 


Lys Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr Leu Val Gly Glu Tyr 
465                 470                 475                 480 


Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe 
                485                 490                 495     


Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp 
            500                 505                 510         


Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly 
        515                 520                 525             


Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro 
    530                 535                 540                 


Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr 
545                 550                 555                 560 


Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu 
                565                 570                 575     


Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro 
            580                 585                 590         


Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg 
        595                 600                 605             


Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser 
    610                 615                 620                 


Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile 
625                 630                 635                 640 


Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu 
                645                 650                 655     


Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly 
            660                 665                 670         


Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His 
        675                 680                 685             


Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp 
    690                 695                 700                 


His Ala Leu Val Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg 
705                 710                 715                 720 


Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val 
                725                 730                 735     


Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu 
            740                 745                 750         


Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val 
        755                 760                 765             


Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr 
    770                 775                 780                 


Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser 
785                 790                 795                 800 


Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu 
                805                 810                 815     


Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His 
            820                 825                 830         


Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val 
        835                 840                 845             


Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe 
    850                 855                 860                 


His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly 
865                 870                 875                 880 


Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu 
                885                 890                 895     


Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp 
            900                 905                 910         


Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys 
        915                 920                 925             


Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr 
    930                 935                 940                 


Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu 
945                 950                 955                 960 


Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe 
                965                 970                 975     


Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val 
            980                 985                 990         


Ala Gly Lys Ser Ile Leu Thr Asn  Ile Ser Glu Val His  Gln Asn Met 
        995                 1000                 1005             


Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Asp Glu Leu  Leu Thr Gly 
    1010                 1015                 1020             


Arg Glu  His Leu Tyr Leu Tyr  Ala Arg Leu Arg Gly  Val Pro Ala 
    1025                 1030                 1035             


Glu Glu  Ile Glu Lys Val Ala  Asn Trp Ser Ile Lys  Ser Leu Gly 
    1040                 1045                 1050             


Leu Thr  Val Tyr Ala Asp Cys  Leu Ala Gly Thr Tyr  Ser Gly Gly 
    1055                 1060                 1065             


Asn Lys  Arg Lys Leu Ser Thr  Ala Ile Ala Leu Ile  Gly Cys Pro 
    1070                 1075                 1080             


Pro Leu  Val Leu Leu Asp Glu  Pro Thr Thr Gly Met  Asp Pro Gln 
    1085                 1090                 1095             


Ala Arg  Arg Met Leu Trp Asn  Val Ile Val Ser Ile  Ile Arg Glu 
    1100                 1105                 1110             


Gly Arg  Ala Val Val Leu Thr  Ser His Ser Met Glu  Glu Cys Glu 
    1115                 1120                 1125             


Ala Leu  Cys Thr Arg Leu Ala  Ile Met Val Lys Gly  Ala Phe Arg 
    1130                 1135                 1140             


Cys Met  Gly Thr Ile Gln His  Leu Lys Ser Lys Phe  Gly Asp Gly 
    1145                 1150                 1155             


Tyr Ile  Val Thr Met Lys Ile  Lys Ser Pro Lys Asp  Asp Leu Leu 
    1160                 1165                 1170             


Pro Asp  Leu Asn Pro Val Glu  Gln Phe Phe Gln Gly  Asn Phe Pro 
    1175                 1180                 1185             


Gly Ser  Val Gln Arg Glu Arg  His Tyr Asn Met Leu  Gln Phe Gln 
    1190                 1195                 1200             


Val Ser  Ser Ser Ser Leu Ala  Arg Ile Phe Gln Leu  Leu Leu Ser 
    1205                 1210                 1215             


His Lys  Asp Ser Leu Leu Ile  Glu Glu Tyr Ser Val  Thr Gln Thr 
    1220                 1225                 1230             


Thr Leu  Asp Gln Val Phe Val  Asn Phe Ala Lys Gln  Gln Thr Glu 
    1235                 1240                 1245             


Ser His  Asp Leu Pro Leu His  Pro Arg Ala Ala Gly  Ala Ser Arg 
    1250                 1255                 1260             


Gln Ala  Gln Asp 
    1265         


<210>  11
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Leu Thr Glu Glu 
    850                 855                 860                 


Thr Glu Asp Pro Glu His Pro Glu Gly Ile His Asp Ser Phe Phe Glu 
865                 870                 875                 880 


Arg Glu His Pro Gly Trp Val Pro Gly Val Cys Val Lys Asn Leu Val 
                885                 890                 895     


Lys Ile Phe Glu Pro Cys Gly Arg Pro Ala Val Asp Arg Leu Asn Ile 
            900                 905                 910         


Thr Phe Tyr Glu Asn Gln Ile Thr Ala Phe Leu Gly His Asn Gly Ala 
        915                 920                 925             


Gly Lys Thr Thr Thr Leu Ser Ile Leu Thr Gly Leu Leu Pro Pro Thr 
    930                 935                 940                 


Ser Gly Thr Val Leu Val Gly Gly Arg Asp Ile Glu Thr Ser Leu Asp 
945                 950                 955                 960 


Ala Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln 
                965                 970                 975     


Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr 
            980                 985                 990         


Val Leu Ala Asp Val Leu Leu Asn  Lys Pro Gly Phe Gly  Asn Arg Cys 
        995                 1000                 1005             


Leu Lys  Glu Gly Trp Leu Pro  Glu Tyr Pro Cys Gly  Asn Ser Thr 
    1010                 1015                 1020             


Pro Trp  Lys Thr Pro Ser Val  Ser Pro Asn Ile Thr  Gln Leu Phe 
    1025                 1030                 1035             


Gln Lys  Gln Lys Trp Thr Gln  Val Asn Pro Ser Pro  Ser Cys Arg 
    1040                 1045                 1050             


Cys Ser  Thr Arg Glu Lys Leu  Thr Met Leu Pro Leu  Arg Leu His 
    1055                 1060                 1065             


Glu Leu  Thr Lys Ile Tyr Pro  Gly Thr Ser Ser Pro  Ala Val Asp 
    1070                 1075                 1080             


Arg Leu  Cys Val Gly Val Arg  Pro Gly Glu Cys Phe  Gly Leu Leu 
    1085                 1090                 1095             


Gly Val  Asn Gly Ala Gly Lys  Thr Thr Thr Phe Lys  Met Leu Thr 
    1100                 1105                 1110             


Gly Asp  Thr Thr Val Thr Ser  Gly Asp Ala Thr Val  Ala Gly Lys 
    1115                 1120                 1125             


Ser Ile  Leu Thr Asn Ile Ser  Glu Val His Gln Asn  Met Gly Tyr 
    1130                 1135                 1140             


Cys Pro  Gln Phe Asp Ala Ile  Asp Glu Leu Leu Thr  Gly Arg Glu 
    1145                 1150                 1155             


His Leu  Tyr Leu Tyr Ala Arg  Leu Arg Gly Val Pro  Ala Glu Glu 
    1160                 1165                 1170             


Ile Glu  Lys Val Ala Asn Trp  Ser Ile Lys Ser Leu  Gly Leu Thr 
    1175                 1180                 1185             


Val Tyr  Ala Asp Cys Leu Ala  Gly Thr Tyr Ser Gly  Gly Asn Lys 
    1190                 1195                 1200             


Arg Lys  Leu Ser Thr Ala Ile  Ala Leu Ile Gly Cys  Pro Pro Leu 
    1205                 1210                 1215             


Val Leu  Leu Asp Glu Pro Thr  Thr Gly Met Asp Pro  Gln Ala Arg 
    1220                 1225                 1230             


Arg Met  Leu Trp Asn Val Ile  Val Ser Ile Ile Arg  Glu Gly Arg 
    1235                 1240                 1245             


Ala Val  Val Leu Thr Ser His  Ser Met Glu Glu Cys  Glu Ala Leu 
    1250                 1255                 1260             


Cys Thr  Arg Leu Ala Ile Met  Val Lys Gly Ala Phe  Arg Cys Met 
    1265                 1270                 1275             


Gly Thr  Ile Gln His Leu Lys  Ser Lys Phe Gly Asp  Gly Tyr Ile 
    1280                 1285                 1290             


Val Thr  Met Lys Ile Lys Ser  Pro Lys Asp Asp Leu  Leu Pro Asp 
    1295                 1300                 1305             


Leu Asn  Pro Val Glu Gln Phe  Phe Gln Gly Asn Phe  Pro Gly Ser 
    1310                 1315                 1320             


Val Gln  Arg Glu Arg His Tyr  Asn Met Leu Gln Phe  Gln Val Ser 
    1325                 1330                 1335             


Ser Ser  Ser Leu Ala Arg Ile  Phe Gln Val Phe Val  Asn Phe Ala 
    1340                 1345                 1350             


<210>  12
<211>  1222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Val Arg Gln Ser 
    850                 855                 860                 


Leu Gly Met Cys Pro Gln His Asn Ile Leu Phe His His Leu Thr Val 
865                 870                 875                 880 


Ala Glu His Met Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu 
                885                 890                 895     


Glu Ala Gln Leu Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His 
            900                 905                 910         


His Lys Arg Asn Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg 
        915                 920                 925             


Lys Leu Ser Val Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile 
    930                 935                 940                 


Leu Asp Glu Pro Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile 
945                 950                 955                 960 


Trp Asp Leu Leu Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser 
                965                 970                 975     


Thr His His Met Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile 
            980                 985                 990         


Ile Ala Gln Gly Arg Leu Tyr Cys  Ser Gly Thr Pro Leu  Phe Leu Lys 
        995                 1000                 1005             


Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr Leu Val  Gly Glu Tyr 
    1010                 1015                 1020             


Pro Ala  Leu Thr Leu His Pro  Trp Ile Tyr Gly Gln  Gln Tyr Thr 
    1025                 1030                 1035             


Phe Phe  Ser Met Asp Glu Pro  Gly Ser Glu Gln Phe  Thr Val Leu 
    1040                 1045                 1050             


Ala Asp  Val Leu Leu Asn Lys  Pro Gly Phe Gly Asn  Arg Cys Leu 
    1055                 1060                 1065             


Lys Glu  Gly Trp Leu Pro Glu  Tyr Pro Cys Gly Asn  Ser Thr Pro 
    1070                 1075                 1080             


Trp Lys  Thr Pro Ser Val Ser  Pro Asn Ile Thr Gln  Leu Phe Gln 
    1085                 1090                 1095             


Lys Gln  Lys Trp Thr Gln Val  Asn Pro Ser Pro Ser  Cys Arg Cys 
    1100                 1105                 1110             


Ser Thr  Arg Glu Lys Leu Thr  Met Leu Pro Leu Arg  Leu His Glu 
    1115                 1120                 1125             


Leu Thr  Lys Ile Tyr Pro Gly  Thr Ser Ser Pro Ala  Val Asp Arg 
    1130                 1135                 1140             


Leu Cys  Val Gly Val Arg Pro  Gly Glu Cys Phe Gly  Leu Leu Gly 
    1145                 1150                 1155             


Val Asn  Gly Ala Gly Lys Thr  Thr Thr Phe Lys Met  Leu Thr Gly 
    1160                 1165                 1170             


Asp Thr  Thr Val Thr Ser Gly  Asp Ala Thr Val Ala  Gly Ile Lys 
    1175                 1180                 1185             


Ser Pro  Lys Asp Asp Leu Leu  Pro Asp Leu Asn Pro  Val Glu Gln 
    1190                 1195                 1200             


Phe Phe  Gln Gly Asn Phe Pro  Gly Ser Val Gln Arg  Glu Val Phe 
    1205                 1210                 1215             


Val Asn  Phe Ala 
    1220         


<210>  13
<211>  1022
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                245                 250                 255     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            260                 265                 270         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        275                 280                 285             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    290                 295                 300                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
305                 310                 315                 320 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                325                 330                 335     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            340                 345                 350         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        355                 360                 365             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    370                 375                 380                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
385                 390                 395                 400 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                405                 410                 415     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            420                 425                 430         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        435                 440                 445             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Leu Thr Glu Glu 
    450                 455                 460                 


Thr Glu Asp Pro Glu His Pro Glu Gly Ile His Asp Ser Phe Phe Glu 
465                 470                 475                 480 


Arg Glu His Pro Gly Trp Val Pro Gly Val Cys Val Lys Asn Leu Val 
                485                 490                 495     


Lys Ile Phe Glu Pro Cys Gly Arg Pro Ala Val Asp Arg Leu Asn Ile 
            500                 505                 510         


Thr Phe Tyr Glu Asn Gln Ile Thr Ala Phe Leu Gly His Asn Gly Ala 
        515                 520                 525             


Gly Lys Thr Thr Thr Leu Ser Ile Leu Thr Gly Leu Leu Pro Pro Thr 
    530                 535                 540                 


Ser Gly Thr Val Leu Val Gly Gly Arg Asp Ile Glu Thr Ser Leu Asp 
545                 550                 555                 560 


Ala His Lys Asp Phe Leu Ala Gln Ile Val Leu Pro Ala Thr Phe Val 
                565                 570                 575     


Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr 
            580                 585                 590         


Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe 
        595                 600                 605             


Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp 
    610                 615                 620                 


Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly 
625                 630                 635                 640 


Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro 
                645                 650                 655     


Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr 
            660                 665                 670         


Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu 
        675                 680                 685             


Thr Met Leu Pro Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser 
    690                 695                 700                 


Ala Gly Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr 
705                 710                 715                 720 


Thr Ser Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr 
                725                 730                 735     


Gly Trp Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp 
            740                 745                 750         


Val Pro Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile 
        755                 760                 765             


Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn 
    770                 775                 780                 


Asn Arg Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile 
785                 790                 795                 800 


Val Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu 
                805                 810                 815     


Ser Gln Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser 
            820                 825                 830         


Ala Asn Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met 
        835                 840                 845             


Val Val Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg 
    850                 855                 860                 


His Phe Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile 
865                 870                 875                 880 


Val Asp Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr 
                885                 890                 895     


Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile 
            900                 905                 910         


Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val 
        915                 920                 925             


Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys 
    930                 935                 940                 


Thr Thr Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly 
945                 950                 955                 960 


Asp Ala Thr Val Ala Gly Ile Lys Ser Pro Lys Asp Asp Leu Leu Pro 
                965                 970                 975     


Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn Phe Pro Gly Ser 
            980                 985                 990         


Val Gln Arg Glu Arg His Tyr Asn  Met Leu Gln Phe Gln  Val Ser Ser 
        995                 1000                 1005             


Ser Ser  Leu Ala Arg Ile Phe  Gln Val Phe Val Asn  Phe Ala 
    1010                 1015                 1020         


<210>  14
<211>  1466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Ala Asn Val Asp Phe 
        35                  40                  45              


Phe Lys Leu Phe Arg Val Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln 
    50                  55                  60                  


Gly Ile Asn Leu Arg Ser Trp Gly Gly Ile Leu Ser Asp Met Ser Pro 
65                  70                  75                  80  


Arg Ile Gln Glu Phe Ile His Arg Pro Ser Met Gln Asp Leu Leu Trp 
                85                  90                  95      


Val Thr Arg Pro Leu Met Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys 
            100                 105                 110         


Leu Met Gly Ile Leu Ser Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly 
        115                 120                 125             


Gly Ser Arg Val Leu Ser Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys 
    130                 135                 140                 


Ala Phe Leu Gly Ile Asp Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr 
145                 150                 155                 160 


Asp Arg Arg Thr Thr Ser Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu 
                165                 170                 175     


Ser Asn Pro Leu Thr Lys Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu 
            180                 185                 190         


Met Gly Lys Ile Leu Tyr Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile 
        195                 200                 205             


Leu Lys Asn Ala Asn Ser Thr Phe Glu Glu Leu Glu His Val Arg Lys 
    210                 215                 220                 


Leu Val Lys Ala Trp Glu Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe 
225                 230                 235                 240 


Asp Asn Ser Thr Gln Met Asn Met Ile Arg Asp Thr Leu Gly Asn Pro 
                245                 250                 255     


Thr Val Lys Asp Phe Leu Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr 
            260                 265                 270         


Ala Glu Ala Ile Leu Asn Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln 
        275                 280                 285             


Ala Asp Asp Met Ala Asn Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr 
    290                 295                 300                 


Asp Arg Thr Leu Arg Leu Val Asn Gln Tyr Leu Glu Cys Leu Val Leu 
305                 310                 315                 320 


Asp Lys Phe Glu Ser Tyr Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala 
                325                 330                 335     


Leu Ser Leu Leu Glu Glu Asn Met Phe Trp Ala Gly Val Val Phe Pro 
            340                 345                 350         


Asp Met Tyr Pro Trp Thr Ser Ser Leu Pro Pro His Val Lys Tyr Lys 
        355                 360                 365             


Ile Arg Met Asp Ile Asp Val Val Glu Lys Thr Asn Lys Ile Lys Asp 
    370                 375                 380                 


Arg Tyr Trp Asp Ser Gly Pro Arg Ala Asp Pro Val Glu Asp Phe Arg 
385                 390                 395                 400 


Tyr Ile Trp Gly Gly Phe Ala Tyr Leu Gln Asp Met Val Glu Gln Gly 
                405                 410                 415     


Ile Thr Arg Ser Gln Val Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu 
            420                 425                 430         


Gln Gln Met Pro Tyr Pro Cys Phe Val Asp Asp Ser Phe Met Ile Ile 
        435                 440                 445             


Leu Asn Arg Cys Phe Pro Ile Phe Met Val Leu Ala Trp Ile Tyr Ser 
    450                 455                 460                 


Val Ser Met Thr Val Lys Ser Ile Val Leu Glu Lys Glu Leu Arg Leu 
465                 470                 475                 480 


Lys Glu Thr Leu Lys Asn Gln Gly Val Ser Asn Ala Val Ile Trp Cys 
                485                 490                 495     


Thr Trp Phe Leu Asp Ser Phe Ser Ile Met Ser Met Ser Ile Phe Leu 
            500                 505                 510         


Leu Thr Ile Phe Ile Met His Gly Arg Ile Leu His Tyr Ser Asp Pro 
        515                 520                 525             


Phe Ile Leu Phe Leu Phe Leu Leu Ala Phe Ser Thr Ala Thr Ile Met 
    530                 535                 540                 


Leu Cys Phe Leu Leu Ser Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala 
545                 550                 555                 560 


Ala Cys Ser Gly Val Ile Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu 
                565                 570                 575     


Cys Phe Ala Trp Gln Asp Arg Met Thr Ala Glu Leu Lys Lys Ala Val 
            580                 585                 590         


Ser Leu Leu Ser Pro Val Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val 
        595                 600                 605             


Arg Phe Glu Glu Gln Gly Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn 
    610                 615                 620                 


Ser Pro Thr Glu Gly Asp Glu Phe Ser Phe Leu Leu Ser Met Gln Met 
625                 630                 635                 640 


Met Leu Leu Asp Ala Ala Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp 
                645                 650                 655     


Gln Val Val Arg Gln Ser Leu Gly Met Cys Pro Gln His Asn Ile Leu 
            660                 665                 670         


Phe His His Leu Thr Val Ala Glu His Met Leu Phe Tyr Ala Gln Leu 
        675                 680                 685             


Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu Glu Met Glu Ala Met Leu 
    690                 695                 700                 


Glu Asp Thr Gly Leu His His Lys Arg Asn Glu Glu Ala Gln Asp Leu 
705                 710                 715                 720 


Ser Gly Gly Met Gln Arg Lys Leu Ser Val Ala Ile Ala Phe Val Gly 
                725                 730                 735     


Asp Ala Lys Val Val Ile Leu Asp Glu Pro Thr Ser Gly Val Asp Pro 
            740                 745                 750         


Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu Leu Lys Tyr Arg Ser Gly 
        755                 760                 765             


Arg Thr Ile Ile Met Ser Thr His His Met Asp Glu Ala Asp Leu Leu 
    770                 775                 780                 


Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly Arg Leu Tyr Cys Ser Gly 
785                 790                 795                 800 


Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly Thr Gly Leu Tyr Leu Thr 
                805                 810                 815     


Leu Val Arg Lys Met Lys Asn Ile Gln Ser Gln Arg Lys Gly Ser Glu 
            820                 825                 830         


Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe Ser Thr Thr Cys Pro Ala 
        835                 840                 845             


His Val Asp Asp Leu Thr Pro Glu Gln Val His Lys Asp Phe Leu Ala 
    850                 855                 860                 


Gln Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser 
865                 870                 875                 880 


Ile Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr 
                885                 890                 895     


Gln Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser 
            900                 905                 910         


Asp Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys 
        915                 920                 925             


Ser Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly 
    930                 935                 940                 


Gly Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe 
945                 950                 955                 960 


Leu Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr 
                965                 970                 975     


Arg Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr 
            980                 985                 990         


Glu Asp Asn Ile Lys Val Trp Phe  Asn Asn Lys Gly Trp  His Ala Leu 
        995                 1000                 1005             


Val Ser  Phe Leu Asn Val Ala  His Asn Ala Ile Leu  Arg Ala Ser 
    1010                 1015                 1020             


Leu Pro  Lys Asp Arg Ser Pro  Glu Asn Phe Leu Trp  Asp Ile Met 
    1025                 1030                 1035             


Asn Tyr  Ser Val Ser Ala Gly  Leu Val Val Gly Ile  Phe Ile Gly 
    1040                 1045                 1050             


Phe Gln  Lys Lys Ala Tyr Thr  Ser Pro Glu Asn Leu  Pro Ala Leu 
    1055                 1060                 1065             


Val Ala  Leu Leu Leu Leu Tyr  Gly Trp Ala Val Ile  Pro Met Met 
    1070                 1075                 1080             


Tyr Pro  Ala Ser Phe Leu Phe  Asp Val Pro Ser Thr  Ala Tyr Val 
    1085                 1090                 1095             


Ala Leu  Ser Cys Ala Asn Leu  Phe Ile Gly Ile Asn  Ser Ser Ala 
    1100                 1105                 1110             


Ile Thr  Phe Ile Leu Glu Leu  Phe Glu Asn Asn Arg  Thr Leu Leu 
    1115                 1120                 1125             


Arg Phe  Asn Ala Val Leu Arg  Lys Leu Leu Ile Val  Phe Pro His 
    1130                 1135                 1140             


Phe Cys  Leu Gly Arg Gly Leu  Ile Asp Leu Ala Leu  Ser Gln Ala 
    1145                 1150                 1155             


Val Thr  Asp Val Tyr Ala Arg  Phe Gly Glu Glu His  Ser Ala Asn 
    1160                 1165                 1170             


Pro Phe  His Trp Asp Leu Ile  Gly Lys Asn Leu Phe  Ala Met Val 
    1175                 1180                 1185             


Val Glu  Gly Val Val Tyr Phe  Leu Leu Thr Leu Leu  Val Gln Arg 
    1190                 1195                 1200             


His Phe  Phe Leu Ser Gln Trp  Ile Ala Glu Pro Thr  Lys Glu Pro 
    1205                 1210                 1215             


Ile Val  Asp Glu Asp Asp Asp  Val Ala Glu Glu Arg  Gln Arg Ile 
    1220                 1225                 1230             


Ile Thr  Gly Gly Asn Lys Thr  Asp Ile Leu Lys Ser  Ile Leu Thr 
    1235                 1240                 1245             


Asn Ile  Ser Glu Val His Gln  Asn Met Gly Tyr Cys  Pro Gln Phe 
    1250                 1255                 1260             


Asp Ala  Ile Asp Glu Leu Leu  Thr Gly Arg Glu His  Leu Tyr Leu 
    1265                 1270                 1275             


Tyr Ala  Arg Leu Arg Gly Val  Pro Ala Glu Glu Ile  Glu Lys Val 
    1280                 1285                 1290             


Ala Asn  Trp Ser Ile Lys Ser  Leu Gly Leu Thr Val  Tyr Ala Asp 
    1295                 1300                 1305             


Cys Leu  Ala Gly Thr Tyr Ser  Gly Gly Asn Lys Arg  Lys Leu Ser 
    1310                 1315                 1320             


Thr Ala  Ile Ala Leu Ile Gly  Cys Pro Pro Leu Val  Leu Leu Asp 
    1325                 1330                 1335             


Glu Pro  Thr Thr Gly Met Asp  Pro Gln Ala Arg Arg  Met Leu Trp 
    1340                 1345                 1350             


Asn Val  Ile Val Ser Ile Ile  Arg Glu Gly Arg Ala  Val Val Leu 
    1355                 1360                 1365             


Thr Ser  His Ser Met Glu Glu  Cys Glu Ala Leu Cys  Thr Arg Leu 
    1370                 1375                 1380             


Ala Ile  Met Val Lys Gly Ala  Phe Arg Cys Met Gly  Thr Ile Gln 
    1385                 1390                 1395             


His Leu  Lys Ser Lys Phe Gly  Asp Gly Tyr Ile Val  Thr Met Lys 
    1400                 1405                 1410             


Leu Leu  Leu Ser His Lys Asp  Ser Leu Leu Ile Glu  Glu Tyr Ser 
    1415                 1420                 1425             


Val Thr  Gln Thr Thr Leu Asp  Gln Val Phe Val Asn  Phe Ala Lys 
    1430                 1435                 1440             


Gln Gln  Thr Glu Ser His Asp  Leu Pro Leu His Pro  Arg Ala Ala 
    1445                 1450                 1455             


Gly Ala  Ser Arg Gln Ala Gln  Asp 
    1460                 1465     


<210>  15
<211>  3483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc actctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct tcccacactc      780

ctagacagcc gttctcaagg tatcaatctg agatcttggg gaggaatatt atctgatatg      840

tcaccaagaa ttcaagagtt tatccatcgg ccgagtatgc aggacttgct gtgggtgacc      900

aggcccctca tgcagaatgg tggtccagag acctttacaa agctgatggg catcctgtct      960

gacctcctgt gtggctaccc cgagggaggt ggctctcggg tgctctcctt caactggtat     1020

gaagacaata actataaggc ctttctgggg attgactcca caaggaagga tcctatctat     1080

tcttatgaca gaagaacaac atccttttgt aatgcattga tccagagcct ggagtcaaat     1140

cctttaacca aaatcgcttg gagggcggca aagcctttgc tgatgggaaa aatcctgtac     1200

actcctgatt cacctgcagc acgaaggata ctgaagaatg ccaactcaac ttttgaagaa     1260

ctggaacacg ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca gatctggtac     1320

ttctttgaca acagcacaca gatgaacatg atcagagata ccctggggaa cccaacagta     1380

aaagactttt tgaataggca gcttggtgaa gaaggtatta ctgctgaagc catcctaaac     1440

ttcctctaca agggccctcg ggaaagccag gctgacgaca tggccaactt cgactggagg     1500

gacatattta acatcactga tcgcaccctc cgcctggtca atcaatacct ggagtgcttg     1560

gtcctggata agtttgaaag ctacaatgat gaaactcagc tcacccaacg tgccctctct     1620

ctactggagg aaaacatgtt ctgggccgga gtggtattcc ctgacatgta tccctggacc     1680

agctctctac caccccacgt gaagtataag atccgaatgg acatagacgt ggtggagaaa     1740

accaataaga ttaaagacag gtattgggat tctggtccca gagctgatcc cgtggaagat     1800

ttccggtaca tctggggcgg gtttgcctat ctgcaggaca tggttgaaca ggggatcaca     1860

aggagccagg tgcaggcgga ggctccagtt ggaatctacc tccagcagat gccctacccc     1920

tgcttcgtgg acgattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg     1980

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg     2040

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg     2100

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg     2160

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     2220

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     2280

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     2340

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     2400

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     2460

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     2520

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     2580

tttccaggag actatggaac cccacttcct tggtactttc ttctacaaga gtcgtattgg     2640

cttggcggtg aagggtgttc aaccagagaa gaaagagccc tggaaaagac cgagccccta     2700

acagaggaaa cggaggatcc agagcaccca gaaggaatac acgactcctt ctttgaacgt     2760

gagcatccag ggtgggttcc tggggtatgc gtgaagaatc tggtaaagat ttttgagccc     2820

tgtggccggc cagctgtgga ccgtctgaac atcaccttct acgagaacca gatcaccgca     2880

ttcctgggcc acaatggagc tgggaaaacc accaccttgt ccatcctgac gggtctgttg     2940

ccaccaacct ctgggactgt gctcgttggg ggaagggaca ttgaaaccag cctggatgca     3000

gtccggcaga gccttggcat gtgtccacag cacaacatcc tgttccacca cctcacggtg     3060

gctgagcaca tgctgttcta tgcccagctg aaaggaaagt cccaggagga ggcccagctg     3120

gagatggaag ccatgttgga ggacacaggc ctccaccaca agcggaatga agaggctcag     3180

gacctatcag gtggcatgca gagaaagctg tcggttgcca ttgcctttgt gggagatgcc     3240

aaggtggtga ttctggacga acccacctct ggggtggacc cttactcgag acgctcaatc     3300

tgggatctgc tcctgaagta tcgctcaggc agaaccatca tcatgtccac tcaccacatg     3360

gacgaggccg acctccttgg ggaccgcatt gccatcattg cccagggaag gctctactgc     3420

tcaggcaccc cactcttcct gaagaactgc tttggcacag gcttgtactt aaccttggtg     3480

tga                                                                   3483


<210>  16
<211>  2754
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

atcgtgctcc cggctacctt tgtgtttttg gctctgatgc tttctattgt tatccctcct      120

tttggcgaat accccgcttt gacccttcac ccctggatat atgggcagca gtacaccttc      180

ttcagcatgg atgaaccagg cagtgagcag ttcacggtac ttgcagacgt cctcctgaat      240

aagccaggct ttggcaaccg ctgcctgaag gaagggtggc ttccggagta cccctgtggc      300

aactcaacac cctggaagac tccttctgtg tccccaaaca tcacccagct gttccagaag      360

cagaaatgga cacaggtcaa cccttcacca tcctgcaggt gcagcaccag ggagaagctc      420

accatgctgc cagagtgccc cgagggtgcc gggggcctcc cgccccccca gagaacacag      480

cgcagcacgg aaattctaca agacctgacg gacaggaaca tctccgactt cttggtaaaa      540

acgtatcctg ctcttataag aagcagctta aagagcaaat tctgggtcaa tgaacagagg      600

tatggaggaa tttccattgg aggaaagctc ccagtcgtcc ccatcacggg ggaagcactt      660

gttgggtttt taagcgacct tggccggatc atgaatgtga gcgggggccc tatcactaga      720

gaggcctcta aagaaatacc tgatttcctt aaacatctag aaactgaaga caacattaag      780

gtgtggttta ataacaaagg ctggcatgcc ctggtcagct ttctcaatgt ggcccacaac      840

gccatcttac gggccagcct gcctaaggac aggagccccg aggagtatgg aatcaccgtc      900

attagccaac ccctgaacct gaccaaggag cagctctcag agattacagt gctgaccact      960

tcagtggatg ctgtggttgc catctgcgtg attttctcca tgtccttcgt cccagccagc     1020

tttgtccttt atttgatcca ggagcgggtg aacaaatcca agcacctcca gtttatcagt     1080

ggagtgagcc ccaccaccta ctgggtgacc aacttcctct gggacatcat gaattattcc     1140

gtgagtgctg ggctggtggt gggcatcttc atcgggtttc agaagaaagc ctacacttct     1200

ccagaaaacc ttcctgccct tgtggcactg ctcctgctgt atggatgggc ggtcattccc     1260

atgatgtacc cagcatcctt cctgtttgat gtccccagca cagcctatgt ggctttatct     1320

tgtgctaatc tgttcatcgg catcaacagc agtgctatta ccttcatctt ggaattattt     1380

gagaataacc ggacgctgct caggttcaac gccgtgctga ggaagctgct cattgtcttc     1440

ccccacttct gcctgggccg gggcctcatt gaccttgcac tgagccaggc tgtgacagat     1500

gtctatgccc ggtttggtga ggagcactct gcaaatccgt tccactggga cctgattggg     1560

aagaacctgt ttgccatggt ggtggaaggg gtggtgtact tcctcctgac cctgctggtc     1620

cagcgccact tcttcctctc ccaatggatt gccgagccca ctaaggagcc cattgttgat     1680

gaagatgatg atgtggctga agaaagacaa agaattatta ctggtggaaa taaaactgac     1740

atcttaaggc tacatgaact aaccaagatt tatccaggca cctccagccc agcagtggac     1800

aggctgtgtg tcggagttcg ccctggagag tgctttggcc tcctgggagt gaatggtgcc     1860

ggcaaaacaa ccacattcaa gatgctcact ggggacacca cagtgacctc aggggatgcc     1920

accgtagcag gcaagagtat tttaaccaat atttctgaag tccatcaaaa tatgggctac     1980

tgtcctcagt ttgatgcaat tgatgagctg ctcacaggac gagaacatct ttacctttat     2040

gcccggcttc gaggtgtacc agcagaagaa atcgaaaagg ttgcaaactg gagtattaag     2100

agcctgggcc tgactgtcta cgccgactgc ctggctggca cgtacagtgg gggcaacaag     2160

cggaaactct ccacagccat cgcactcatt ggctgcccac cgctggtgct gctggatgag     2220

cccaccacag ggatggaccc ccaggcacgc cgcatgctgt ggaacgtcat cgtgagcatc     2280

atcagagaag ggagggctgt ggtcctcaca tcccacagca tggaagaatg tgaggcactg     2340

tgtacccggc tggccatcat ggtaaagggc gcctttcgat gtatgggcac cattcagcat     2400

ctcaagtcca aatttggaga tggctatatc gtcacaatga agatcaaatc cccgaaggac     2460

gacctgcttc ctgacctgaa ccctgtggag cagttcttcc aggggaactt cccaggcagt     2520

gtgcagaggg agaggcacta caacatgctc cagttccagg tctcctcctc ctccctggcg     2580

aggatcttcc agctcctcct ctcccacaag gacagcctgc tcatcgagga gtactcagtc     2640

acacagacca cactggacca ggtgtttgta aattttgcta aacagcagac tgaaagtcat     2700

gacctccctc tgcaccctcg agctgctgga gccagtcgac aagcccagga ctga           2754


<210>  17
<211>  3459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc actctacatg ccctacccct gcttcgtgga cgattctttc      180

atgatcatcc tgaaccgctg tttccctatc ttcatggtgc tggcatggat ctactctgtc      240

tccatgactg tgaagagcat cgtcttggag aaggagttgc gactgaagga gaccttgaaa      300

aatcagggtg tctccaatgc agtgatttgg tgtacctggt tcctggacag cttctccatc      360

atgtcgatga gcatcttcct cctgacgata ttcatcatgc atggaagaat cctacattac      420

agcgacccat tcatcctctt cctgttcttg ttggctttct ccactgccac catcatgctg      480

tgctttctgc tcagcacctt cttctccaag gccagtctgg cagcagcctg tagtggtgtc      540

atctatttca ccctctacct gccacacatc ctgtgcttcg cctggcagga ccgcatgacc      600

gctgagctga agaaggctgt gagcttactg tctccggtgg catttggatt tggcactgag      660

tacctggttc gctttgaaga gcaaggcctg gggctgcagt ggagcaacat cgggaacagt      720

cccacggaag gggacgaatt cagcttcctg ctgtccatgc agatgatgct ccttgatgct      780

gctgtctatg gcttactcgc ttggtacctt gatcaggtgt ttccaggaga ctatggaacc      840

ccacttcctt ggtactttct tctacaagag tcgtattggc ttggcggtga agggtgttca      900

accagagaag aaagagccct ggaaaagacc gagcccctaa cagaggaaac ggaggatcca      960

gagcacccag aaggaataca cgactccttc tttgaacgtg agcatccagg gtgggttcct     1020

ggggtatgcg tgaagaatct ggtaaagatt tttgagccct gtggccggcc agctgtggac     1080

cgtctgaaca tcaccttcta cgagaaccag atcaccgcat tcctgggcca caatggagct     1140

gggaaaacca ccaccttgtc catcctgacg ggtctgttgc caccaacctc tgggactgtg     1200

ctcgttgggg gaagggacat tgaaaccagc ctggatgcag tccggcagag ccttggcatg     1260

tgtccacagc acaacatcct gttccaccac ctcacggtgg ctgagcacat gctgttctat     1320

gcccagctga aaggaaagtc ccaggaggag gcccagctgg agatggaagc catgttggag     1380

gacacaggcc tccaccacaa gcggaatgaa gaggctcagg acctatcagg tggcatgcag     1440

agaaagctgt cggttgccat tgcctttgtg ggagatgcca aggtggtgat tctggacgaa     1500

cccacctctg gggtggaccc ttactcgaga cgctcaatct gggatctgct cctgaagtat     1560

cgctcaggca gaaccatcat catgtccact caccacatgg acgaggccga cctccttggg     1620

gaccgcattg ccatcattgc ccagggaagg ctctactgct caggcacccc actcttcctg     1680

aagaactgct ttggcacagg cttggacttc ctggcgcaga tcgtgctccc ggctaccttt     1740

gtgtttttgg ctctgatgct ttctattgtt atccctcctt ttggcgaata ccccgctacc     1800

acctactggg tgaccaactt cctctgggac atcatgaatt attccgtgag tgctgggctg     1860

gtggtgggca tcttcatcgg gtttcagaag aaagcctaca cttctccaga aaaccttcct     1920

gcccttgtgg cactgctcct gctgtatgga tgggcggtca ttcccatgat gtacccagca     1980

tccttcctgt ttgatgtccc cagcacagcc tatgtggctt tatcttgtgc taatctgttc     2040

atcggcatca acagcagtgc tattaccttc atcttggaat tatttgagaa taaccggacg     2100

ctgctcaggt tcaacgccgt gctgaggaag ctgctcattg tcttccccca cttctgcctg     2160

ggccggggcc tcattgacct tgcactgagc caggctgtga cagatgtcta tgcccggttt     2220

ggtgaggagc actctgcaaa tccgttccac tgggacctga ttgggaagaa cctgtttgcc     2280

atggtggtgg aaggggtggt gtacttcctc ctgaccctgc tggtccagcg ccacttcttc     2340

ctctcccaat ggattgccga gcccactaag gagcccattg ttgatgaaga tgatgatgtg     2400

gctgaagaaa gacaaagaat tattactggt ggaaataaaa ctgacatctt aaggctacat     2460

gaactaacca agatttatcc aggcacctcc agcccagcag tggacaggct gtgtgtcgga     2520

gttcgccctg gagagtgctt tggcctcctg ggagtgaatg gtgccggcaa aacaaccaca     2580

ttcaagatgc tcactgggga caccacagtg acctcagggg atgccaccgt agcaggcaag     2640

agtattttaa ccaatatttc tgaagtccat caaaatatgg gctactgtcc tcagtttgat     2700

gcaattgatg agctgctcac aggacgagaa catctttacc tttatgcccg gcttcgaggt     2760

gtaccagcag aagaaatcga aaaggttgca aactggagta ttaagagcct gggcctgact     2820

gtctacgccg actgcctggc tggcacgtac agtgggggca acaagcggaa actctccaca     2880

gccatcgcac tcattggctg cccaccgctg gtgctgctgg atgagcccac cacagggatg     2940

gacccccagg cacgccgcat gctgtggaac gtcatcgtga gcatcatcag agaagggagg     3000

gctgtggtcc tcacatccca cagcatggaa gaatgtgagg cactgtgtac ccggctggcc     3060

atcatggtaa agggcgcctt tcgatgtatg ggcaccattc agcatctcaa gtccaaattt     3120

ggagatggct atatcgtcac aatgaagatc aaatccccga aggacgacct gcttcctgac     3180

ctgaaccctg tggagcagtt cttccagggg aacttcccag gcagtgtgca gagggagagg     3240

cactacaaca tgctccagtt ccaggtctcc tcctcctccc tggcgaggat cttccagctc     3300

ctcctctccc acaaggacag cctgctcatc gaggagtact cagtcacaca gaccacactg     3360

gaccaggtgt ttgtaaattt tgctaaacag cagactgaaa gtcatgacct ccctctgcac     3420

cctcgagctg ctggagccag tcgacaagcc caggactga                            3459


<210>  18
<211>  3780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc actctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct tcccacactc      780

ctagacagcc gttctcaagg tatcaatctg agatcttggg gaggaatatt atctgatatg      840

tcaccaagaa ttcaagagtt tatccatcgg ccgagtatgc aggacttgct gtgggtgacc      900

aggcccctca tgcagaatgg tggtccagag acctttacaa agctgatggg catcctgtct      960

gacctcctgt gtggctaccc cgagggaggt ggctctcggg tgctctcctt caactggtat     1020

gaagacaata actataaggc ctttctgggg attgactcca caaggaagga tcctatctat     1080

tcttatgaca gaagaacaac atccttttgt aatgcattga tccagagcct ggagtcaaat     1140

cctttaacca aaatcgcttg gagggcggca aagcctttgc tgatgggaaa aatcctgtac     1200

actcctgatt cacctgcagc acgaaggata ctgaagaatg ccaactcaac ttttgaagaa     1260

ctggaacacg ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca gatctggtac     1320

ttctttgaca acagcacaca gatgaacatg atcagagata ccctggggaa cccaacagta     1380

aaagactttt tgaataggca gcttggtgaa gaaggtatta ctgctgaagc catcctaaac     1440

ttcctctaca agggccctcg ggaaagccag gctgacgaca tggccaactt cgactggagg     1500

gacatattta acatcactga tcgcaccctc cgcctggtca atcaatacct ggagtgcttg     1560

gtcctggata agtttgaaag ctacaatgat gaaactcagc tcacccaacg tgccctctct     1620

ctactggagg aaaacatgtt ctgggccgga gtggtattcc ctgacatgta tccctggacc     1680

agctctctac caccccacgt gaagtataag atccgaatgg acatagacgt ggtggagaaa     1740

accaataaga ttaaagacag gtattgggat tctggtccca gagctgatcc cgtggaagat     1800

ttccggtaca tctggggcgg gtttgcctat ctgcaggaca tggttgaaca ggggatcaca     1860

aggagccagg tgcaggcgga ggctccagtt ggaatctacc tccagcagat gccctacccc     1920

tgcttcgtgg acgattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg     1980

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg     2040

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg     2100

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg     2160

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     2220

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     2280

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     2340

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     2400

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     2460

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     2520

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     2580

gttcctgggg tatgcgtgaa gaatctggta aagatttttg agccctgtgg ccggccagct     2640

gtggaccgtc tgaacatcac cttctacgag aaccagatca ccgcattcct gggccacaat     2700

ggagctggga aaaccaccac cttgtccatc ctgacgggtc tgttgccacc aacctctggg     2760

actgtgctcg ttgggggaag ggacattgaa accagcctgg atgcagtccg gcagagcctt     2820

ggcatgtgtc cacagcacaa catcctgttc caccacctca cggtggctga gcacatgctg     2880

ttctatgccc agctgaaagg aaagtcccag gaggaggccc agctggagat ggaagccatg     2940

ttggaggaca caggcctcca ccacaagcgg aatgaagagg ctcaggacct atcaggtggc     3000

atgcagagaa agctgtcggt tgccattgcc tttgtgggag atgccaaggt ggtgattctg     3060

gacgaaccca cctctggggt ggacccttac tcgagacgct caatctggga tctgctcctg     3120

aagtatcgct caggcagaac catcatcatg tccactcacc acatggacga ggccgacctc     3180

cttggggacc gcattgccat cattgcccag ggaaggctct actgctcagg caccccactc     3240

ttcctgaaga actgctttgt gaccaacttc ctctgggaca tcatgaatta ttccgtgagt     3300

gctgggctgg tggtgggcat cttcatcggg tttcagaaga aagcctacac ttctccagaa     3360

aaccttcctg cccttgtggc actgctcctg ctgtatggat gggcggtcat tcccatgatg     3420

tacccagcat ccttcctgtt tgatgtcccc agcacagcct atgtggcttt atcttgtgct     3480

aatctgttca tcggcatcaa cagcagtgct attaccttca tcttggaatt atttgagaat     3540

aaccggacgc tgctcaggtt caacgccgtg ctgaggaagc tgctcattgt cttcccccac     3600

ttctgcctgg gccggggcct cattgacctt gcactgagcc aggctgtgac agatgtctat     3660

gcccggtttg gtgaggagca ctctgcaaat ccgttccact gggacctgat tgggaagaac     3720

ctgtttgcca tggtggtgga aggggtggtg tacttcctcc tgaccctgct ggtccagtga     3780


<210>  19
<211>  3498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaacgt ggacgattct ttcatgatca tcctgaaccg ctgtttccct      180

atcttcatgg tgctggcatg gatctactct gtctccatga ctgtgaagag catcgtcttg      240

gagaaggagt tgcgactgaa ggagaccttg aaaaatcagg gtgtctccaa tgcagtgatt      300

tggtgtacct ggttcctgga cagcttctcc atcatgtcga tgagcatctt cctcctgacg      360

atattcatca tgcatggaag aatcctacat tacagcgacc cattcatcct cttcctgttc      420

ttgttggctt tctccactgc caccatcatg ctgtgctttc tgctcagcac cttcttctcc      480

aaggccagtc tggcagcagc ctgtagtggt gtcatctatt tcaccctcta cctgccacac      540

atcctgtgct tcgcctggca ggaccgcatg accgctgagc tgaagaaggc tgtgagctta      600

ctgtctccgg tggcatttgg atttggcact gagtacctgg ttcgctttga agagcaaggc      660

ctggggctgc agtggagcaa catcgggaac agtcccacgg aaggggacga attcagcttc      720

ctgctgtcca tgcagatgat gctccttgat gctgctgtct atggcttact cgcttggtac      780

cttgatcagg tgttcctggc gcagatcgtg ctcccggcta cctttgtgtt tttggctctg      840

atgctttcta ttgttatccc tccttttggc gaataccccg ctttgaccct tcacccctgg      900

atatatgggc agcagtacac cttcttcagc atggatgaac caggcagtga gcagttcacg      960

gtacttgcag acgtcctcct gaataagcca ggctttggca accgctgcct gaaggaaggg     1020

tggcttccgg agtacccctg tggcaactca acaccctgga agactccttc tgtgtcccca     1080

aacatcaccc agctgttcca gaagcagaaa tggacacagg tcaacccttc accatcctgc     1140

aggtgcagca ccagggagaa gctcaccatg ctgccagagt gccccgaggg tgccgggggc     1200

ctcccgcccc cccagagaac acagcgcagc acggaaattc tacaagacct gacggacagg     1260

aacatctccg acttcttggt aaaaacgtat cctgctctta taagaagcag cttaaagagc     1320

aaattctggg tcaatgaaca gaggtatgga ggaatttcca ttggaggaaa gctcccagtc     1380

gtccccatca cgggggaagc acttgttggg tttttaagcg accttggccg gatcatgaat     1440

gtgagcgggg gccctatcac tagagaggcc tctaaagaaa tacctgattt ccttaaacat     1500

ctagaaactg aagacaacat taaggtgtgg tttaataaca aaggctggca tgccctggtc     1560

agctttctca atgtggccca caacgccatc ttacgggcca gcctgcctaa ggacaggagc     1620

cccgaggagt atggaatcac cgtcattagc caacccctga acctgaccaa ggagcagctc     1680

tcagagatta cagtgctgac cacttcagtg gatgctgtgg ttgccatctg cgtgattttc     1740

tccatgtcct tcgtcccagc cagctttgtc ctttatttga tccaggagcg ggtgaacaaa     1800

tccaagcacc tccagtttat cagtggagtg agccccacca cctactgggt gaccaacttc     1860

ctctgggaca tcatgaatta ttccgtgagt gctgggctgg tggtgggcat cttcatcggg     1920

tttcagaaga aagcctacac ttctccagaa aaccttcctg cccttgtggc actgctcctg     1980

ctgtatggat gggcggtcat tcccatgatg tacccagcat ccttcctgtt tgatgtcccc     2040

agcacagcct atgtggcttt atcttgtgct aatctgttca tcggcatcaa cagcagtgct     2100

attaccttca tcttggaatt atttgagaat aaccggacgc tgctcaggtt caacgccgtg     2160

ctgaggaagc tgctcattgt cttcccccac ttctgcctgg gccggggcct cattgacctt     2220

gcactgagcc aggctgtgac agatgtctat gcccggtttg gtgaggagca ctctgcaaat     2280

ccgttccact gggacctgat tgggaagaac ctgtttgcca tggtggtgga aggggtggtg     2340

tacttcctcc tgaccctgct ggtccagcgc cacttcttcc tctcccaatg gattgccgag     2400

cccactaagg agcccattgt tgatgaagat gatgatgtgg ctgaagaaag acaaagaatt     2460

attactggtg gaaataaaac tgacatctta aggctacatg aactaaccaa gatttatcca     2520

ggcacctcca gcccagcagt ggacaggctg tgtgtcggag ttcgccctgg agagtgcttt     2580

ggcctcctgg gagtgaatgg tgccggcaaa acaaccacat tcaagatgct cactggggac     2640

accacagtga cctcagggga tgccaccgta gcaggcaaga gtattttaac caatatttct     2700

gaagtccatc aaaatatggg ctactgtcct cagtttgatg caattgatga gctgctcaca     2760

ggacgagaac atctttacct ttatgcccgg cttcgaggtg taccagcaga agaaatcgaa     2820

aaggttgcaa actggagtat taagagcctg ggcctgactg tctacgccga ctgcctggct     2880

ggcacgtaca gtgggggcaa caagcggaaa ctctccacag ccatcgcact cattggctgc     2940

ccaccgctgg tgctgctgga tgagcccacc acagggatgg acccccaggc acgccgcatg     3000

ctgtggaacg tcatcgtgag catcatcaga gaagggaggg ctgtggtcct cacatcccac     3060

agcatggaag aatgtgaggc actgtgtacc cggctggcca tcatggtaaa gggcgccttt     3120

cgatgtatgg gcaccattca gcatctcaag tccaaatttg gagatggcta tatcgtcaca     3180

atgaagatca aatccccgaa ggacgacctg cttcctgacc tgaaccctgt ggagcagttc     3240

ttccagggga acttcccagg cagtgtgcag agggagaggc actacaacat gctccagttc     3300

caggtctcct cctcctccct ggcgaggatc ttccagctcc tcctctccca caaggacagc     3360

ctgctcatcg aggagtactc agtcacacag accacactgg accaggtgtt tgtaaatttt     3420

gctaaacagc agactgaaag tcatgacctc cctctgcacc ctcgagctgc tggagccagt     3480

cgacaagccc aggactga                                                   3498


<210>  20
<211>  1160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 


Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     


Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         


Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             


Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 


Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 


Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     


Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         


Asp Ile Glu Thr Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys 
        995                 1000                 1005             


Pro Gln  His Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His 
    1010                 1015                 1020             


Met Leu  Phe Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala 
    1025                 1030                 1035             


Gln Leu  Glu Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His 
    1040                 1045                 1050             


Lys Arg  Asn Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg 
    1055                 1060                 1065             


Lys Leu  Ser Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val 
    1070                 1075                 1080             


Ile Leu  Asp Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg 
    1085                 1090                 1095             


Ser Ile  Trp Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile 
    1100                 1105                 1110             


Ile Met  Ser Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp 
    1115                 1120                 1125             


Arg Ile  Ala Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr 
    1130                 1135                 1140             


Pro Leu  Phe Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr 
    1145                 1150                 1155             


Leu Val  
    1160 


<210>  21
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu 
            20                  25                  30          


Met Leu Ser Ile Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr 
        35                  40                  45              


Leu His Pro Trp Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp 
    50                  55                  60                  


Glu Pro Gly Ser Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn 
65                  70                  75                  80  


Lys Pro Gly Phe Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu 
                85                  90                  95      


Tyr Pro Cys Gly Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro 
            100                 105                 110         


Asn Ile Thr Gln Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro 
        115                 120                 125             


Ser Pro Ser Cys Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro 
    130                 135                 140                 


Glu Cys Pro Glu Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln 
145                 150                 155                 160 


Arg Ser Thr Glu Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp 
                165                 170                 175     


Phe Leu Val Lys Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser 
            180                 185                 190         


Lys Phe Trp Val Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly 
        195                 200                 205             


Lys Leu Pro Val Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu 
    210                 215                 220                 


Ser Asp Leu Gly Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg 
225                 230                 235                 240 


Glu Ala Ser Lys Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu 
                245                 250                 255     


Asp Asn Ile Lys Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val 
            260                 265                 270         


Ser Phe Leu Asn Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro 
        275                 280                 285             


Lys Asp Arg Ser Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro 
    290                 295                 300                 


Leu Asn Leu Thr Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr 
305                 310                 315                 320 


Ser Val Asp Ala Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe 
                325                 330                 335     


Val Pro Ala Ser Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys 
            340                 345                 350         


Ser Lys His Leu Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp 
        355                 360                 365             


Val Thr Asn Phe Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly 
    370                 375                 380                 


Leu Val Val Gly Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser 
385                 390                 395                 400 


Pro Glu Asn Leu Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp 
                405                 410                 415     


Ala Val Ile Pro Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro 
            420                 425                 430         


Ser Thr Ala Tyr Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile 
        435                 440                 445             


Asn Ser Ser Ala Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg 
    450                 455                 460                 


Thr Leu Leu Arg Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe 
465                 470                 475                 480 


Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln 
                485                 490                 495     


Ala Val Thr Asp Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn 
            500                 505                 510         


Pro Phe His Trp Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val 
        515                 520                 525             


Glu Gly Val Val Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe 
    530                 535                 540                 


Phe Leu Ser Gln Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp 
545                 550                 555                 560 


Glu Asp Asp Asp Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly 
                565                 570                 575     


Asn Lys Thr Asp Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro 
            580                 585                 590         


Gly Thr Ser Ser Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro 
        595                 600                 605             


Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr 
    610                 615                 620                 


Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala 
625                 630                 635                 640 


Thr Val Ala Gly Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln 
                645                 650                 655     


Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr 
            660                 665                 670         


Gly Arg Glu His Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala 
        675                 680                 685             


Glu Glu Ile Glu Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu 
    690                 695                 700                 


Thr Val Tyr Ala Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys 
705                 710                 715                 720 


Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val 
                725                 730                 735     


Leu Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met 
            740                 745                 750         


Leu Trp Asn Val Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val 
        755                 760                 765             


Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu 
    770                 775                 780                 


Ala Ile Met Val Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His 
785                 790                 795                 800 


Leu Lys Ser Lys Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys 
                805                 810                 815     


Ser Pro Lys Asp Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe 
            820                 825                 830         


Phe Gln Gly Asn Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn 
        835                 840                 845             


Met Leu Gln Phe Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln 
    850                 855                 860                 


Leu Leu Leu Ser His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val 
865                 870                 875                 880 


Thr Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln 
                885                 890                 895     


Thr Glu Ser His Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser 
            900                 905                 910         


Arg Gln Ala Gln Asp 
        915         


<210>  22
<211>  1152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Met Pro Tyr Pro Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu 
    50                  55                  60                  


Asn Arg Cys Phe Pro Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val 
65                  70                  75                  80  


Ser Met Thr Val Lys Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys 
                85                  90                  95      


Glu Thr Leu Lys Asn Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr 
            100                 105                 110         


Trp Phe Leu Asp Ser Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu 
        115                 120                 125             


Thr Ile Phe Ile Met His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe 
    130                 135                 140                 


Ile Leu Phe Leu Phe Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu 
145                 150                 155                 160 


Cys Phe Leu Leu Ser Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala 
                165                 170                 175     


Cys Ser Gly Val Ile Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys 
            180                 185                 190         


Phe Ala Trp Gln Asp Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser 
        195                 200                 205             


Leu Leu Ser Pro Val Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg 
    210                 215                 220                 


Phe Glu Glu Gln Gly Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser 
225                 230                 235                 240 


Pro Thr Glu Gly Asp Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met 
                245                 250                 255     


Leu Leu Asp Ala Ala Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln 
            260                 265                 270         


Val Phe Pro Gly Asp Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu 
        275                 280                 285             


Gln Glu Ser Tyr Trp Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu 
    290                 295                 300                 


Arg Ala Leu Glu Lys Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro 
305                 310                 315                 320 


Glu His Pro Glu Gly Ile His Asp Ser Phe Phe Glu Arg Glu His Pro 
                325                 330                 335     


Gly Trp Val Pro Gly Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu 
            340                 345                 350         


Pro Cys Gly Arg Pro Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu 
        355                 360                 365             


Asn Gln Ile Thr Ala Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr 
    370                 375                 380                 


Thr Leu Ser Ile Leu Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val 
385                 390                 395                 400 


Leu Val Gly Gly Arg Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln 
                405                 410                 415     


Ser Leu Gly Met Cys Pro Gln His Asn Ile Leu Phe His His Leu Thr 
            420                 425                 430         


Val Ala Glu His Met Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln 
        435                 440                 445             


Glu Glu Ala Gln Leu Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu 
    450                 455                 460                 


His His Lys Arg Asn Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln 
465                 470                 475                 480 


Arg Lys Leu Ser Val Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val 
                485                 490                 495     


Ile Leu Asp Glu Pro Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser 
            500                 505                 510         


Ile Trp Asp Leu Leu Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met 
        515                 520                 525             


Ser Thr His His Met Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala 
    530                 535                 540                 


Ile Ile Ala Gln Gly Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu 
545                 550                 555                 560 


Lys Asn Cys Phe Gly Thr Gly Leu Asp Phe Leu Ala Gln Ile Val Leu 
                565                 570                 575     


Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro 
            580                 585                 590         


Pro Phe Gly Glu Tyr Pro Ala Thr Thr Tyr Trp Val Thr Asn Phe Leu 
        595                 600                 605             


Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile 
    610                 615                 620                 


Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro 
625                 630                 635                 640 


Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro Met 
                645                 650                 655     


Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr Val 
            660                 665                 670         


Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile 
        675                 680                 685             


Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe 
    690                 695                 700                 


Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys Leu 
705                 710                 715                 720 


Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp Val 
                725                 730                 735     


Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp Asp 
            740                 745                 750         


Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val Tyr 
        755                 760                 765             


Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln Trp 
    770                 775                 780                 


Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp Val 
785                 790                 795                 800 


Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile 
                805                 810                 815     


Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro 
            820                 825                 830         


Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe Gly 
        835                 840                 845             


Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met Leu 
    850                 855                 860                 


Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly Lys 
865                 870                 875                 880 


Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr Cys 
                885                 890                 895     


Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His Leu 
            900                 905                 910         


Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu Lys 
        915                 920                 925             


Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp 
    930                 935                 940                 


Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr 
945                 950                 955                 960 


Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu Pro 
                965                 970                 975     


Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val Ile 
            980                 985                 990         


Val Ser Ile Ile Arg Glu Gly Arg  Ala Val Val Leu Thr  Ser His Ser 
        995                 1000                 1005             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Leu Ala  Ile Met Val 
    1010                 1015                 1020             


Lys Gly  Ala Phe Arg Cys Met  Gly Thr Ile Gln His  Leu Lys Ser 
    1025                 1030                 1035             


Lys Phe  Gly Asp Gly Tyr Ile  Val Thr Met Lys Ile  Lys Ser Pro 
    1040                 1045                 1050             


Lys Asp  Asp Leu Leu Pro Asp  Leu Asn Pro Val Glu  Gln Phe Phe 
    1055                 1060                 1065             


Gln Gly  Asn Phe Pro Gly Ser  Val Gln Arg Glu Arg  His Tyr Asn 
    1070                 1075                 1080             


Met Leu  Gln Phe Gln Val Ser  Ser Ser Ser Leu Ala  Arg Ile Phe 
    1085                 1090                 1095             


Gln Leu  Leu Leu Ser His Lys  Asp Ser Leu Leu Ile  Glu Glu Tyr 
    1100                 1105                 1110             


Ser Val  Thr Gln Thr Thr Leu  Asp Gln Val Phe Val  Asn Phe Ala 
    1115                 1120                 1125             


Lys Gln  Gln Thr Glu Ser His  Asp Leu Pro Leu His  Pro Arg Ala 
    1130                 1135                 1140             


Ala Gly  Ala Ser Arg Gln Ala  Gln Asp 
    1145                 1150         


<210>  23
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Val Pro Gly Val 
    850                 855                 860                 


Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro Ala 
865                 870                 875                 880 


Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala Phe 
                885                 890                 895     


Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu Thr 
            900                 905                 910         


Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg Asp 
        915                 920                 925             


Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys Pro 
    930                 935                 940                 


Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met Leu 
945                 950                 955                 960 


Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu Glu 
                965                 970                 975     


Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn Glu 
            980                 985                 990         


Glu Ala Gln Asp Leu Ser Gly Gly  Met Gln Arg Lys Leu  Ser Val Ala 
        995                 1000                 1005             


Ile Ala  Phe Val Gly Asp Ala  Lys Val Val Ile Leu  Asp Glu Pro 
    1010                 1015                 1020             


Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg Ser Ile  Trp Asp Leu 
    1025                 1030                 1035             


Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile Ile Met  Ser Thr His 
    1040                 1045                 1050             


His Met  Asp Glu Ala Asp Leu  Leu Gly Asp Arg Ile  Ala Ile Ile 
    1055                 1060                 1065             


Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr Pro Leu  Phe Leu Lys 
    1070                 1075                 1080             


Asn Cys  Phe Val Thr Asn Phe  Leu Trp Asp Ile Met  Asn Tyr Ser 
    1085                 1090                 1095             


Val Ser  Ala Gly Leu Val Val  Gly Ile Phe Ile Gly  Phe Gln Lys 
    1100                 1105                 1110             


Lys Ala  Tyr Thr Ser Pro Glu  Asn Leu Pro Ala Leu  Val Ala Leu 
    1115                 1120                 1125             


Leu Leu  Leu Tyr Gly Trp Ala  Val Ile Pro Met Met  Tyr Pro Ala 
    1130                 1135                 1140             


Ser Phe  Leu Phe Asp Val Pro  Ser Thr Ala Tyr Val  Ala Leu Ser 
    1145                 1150                 1155             


Cys Ala  Asn Leu Phe Ile Gly  Ile Asn Ser Ser Ala  Ile Thr Phe 
    1160                 1165                 1170             


Ile Leu  Glu Leu Phe Glu Asn  Asn Arg Thr Leu Leu  Arg Phe Asn 
    1175                 1180                 1185             


Ala Val  Leu Arg Lys Leu Leu  Ile Val Phe Pro His  Phe Cys Leu 
    1190                 1195                 1200             


Gly Arg  Gly Leu Ile Asp Leu  Ala Leu Ser Gln Ala  Val Thr Asp 
    1205                 1210                 1215             


Val Tyr  Ala Arg Phe Gly Glu  Glu His Ser Ala Asn  Pro Phe His 
    1220                 1225                 1230             


Trp Asp  Leu Ile Gly Lys Asn  Leu Phe Ala Met Val  Val Glu Gly 
    1235                 1240                 1245             


Val Val  Tyr Phe Leu Leu Thr  Leu Leu Val Gln 
    1250                 1255                 


<210>  24
<211>  1165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Val Asp 
        35                  40                  45              


Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro Ile Phe Met Val 
    50                  55                  60                  


Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys Ser Ile Val Leu 
65                  70                  75                  80  


Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn Gln Gly Val Ser 
                85                  90                  95      


Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser Phe Ser Ile Met 
            100                 105                 110         


Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met His Gly Arg Ile 
        115                 120                 125             


Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe Leu Leu Ala Phe 
    130                 135                 140                 


Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser Thr Phe Phe Ser 
145                 150                 155                 160 


Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile Tyr Phe Thr Leu 
                165                 170                 175     


Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp Arg Met Thr Ala 
            180                 185                 190         


Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val Ala Phe Gly Phe 
        195                 200                 205             


Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly Leu Gly Leu Gln 
    210                 215                 220                 


Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp Glu Phe Ser Phe 
225                 230                 235                 240 


Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala Val Tyr Gly Leu 
                245                 250                 255     


Leu Ala Trp Tyr Leu Asp Gln Val Phe Leu Ala Gln Ile Val Leu Pro 
            260                 265                 270         


Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile Val Ile Pro Pro 
        275                 280                 285             


Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp Ile Tyr Gly Gln 
    290                 295                 300                 


Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser Glu Gln Phe Thr 
305                 310                 315                 320 


Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe Gly Asn Arg Cys 
                325                 330                 335     


Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly Asn Ser Thr Pro 
            340                 345                 350         


Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln Leu Phe Gln Lys 
        355                 360                 365             


Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys Arg Cys Ser Thr 
    370                 375                 380                 


Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu Gly Ala Gly Gly 
385                 390                 395                 400 


Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu Ile Leu Gln Asp 
                405                 410                 415     


Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys Thr Tyr Pro Ala 
            420                 425                 430         


Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val Asn Glu Gln Arg 
        435                 440                 445             


Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val Val Pro Ile Thr 
    450                 455                 460                 


Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly Arg Ile Met Asn 
465                 470                 475                 480 


Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys Glu Ile Pro Asp 
                485                 490                 495     


Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys Val Trp Phe Asn 
            500                 505                 510         


Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn Val Ala His Asn 
        515                 520                 525             


Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser Pro Glu Glu Tyr 
    530                 535                 540                 


Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr Lys Glu Gln Leu 
545                 550                 555                 560 


Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala Val Val Ala Ile 
                565                 570                 575     


Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser Phe Val Leu Tyr 
            580                 585                 590         


Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu Gln Phe Ile Ser 
        595                 600                 605             


Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe Leu Trp Asp Ile 
    610                 615                 620                 


Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly Ile Phe Ile Gly 
625                 630                 635                 640 


Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu Pro Ala Leu Val 
                645                 650                 655     


Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro Met Met Tyr Pro 
            660                 665                 670         


Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr Val Ala Leu Ser 
        675                 680                 685             


Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala Ile Thr Phe Ile 
    690                 695                 700                 


Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg Phe Asn Ala Val 
705                 710                 715                 720 


Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys Leu Gly Arg Gly 
                725                 730                 735     


Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp Val Tyr Ala Arg 
            740                 745                 750         


Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp Asp Leu Ile Gly 
        755                 760                 765             


Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val Tyr Phe Leu Leu 
    770                 775                 780                 


Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln Trp Ile Ala Glu 
785                 790                 795                 800 


Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp Val Ala Glu Glu 
                805                 810                 815     


Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp Ile Leu Arg Leu 
            820                 825                 830         


His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser Pro Ala Val Asp 
        835                 840                 845             


Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly 
    850                 855                 860                 


Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met Leu Thr Gly Asp 
865                 870                 875                 880 


Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly Lys Ser Ile Leu 
                885                 890                 895     


Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr Cys Pro Gln Phe 
            900                 905                 910         


Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His Leu Tyr Leu Tyr 
        915                 920                 925             


Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu Lys Val Ala Asn 
    930                 935                 940                 


Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala Asp Cys Leu Ala 
945                 950                 955                 960 


Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala 
                965                 970                 975     


Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu Pro Thr Thr Gly 
            980                 985                 990         


Met Asp Pro Gln Ala Arg Arg Met  Leu Trp Asn Val Ile  Val Ser Ile 
        995                 1000                 1005             


Ile Arg  Glu Gly Arg Ala Val  Val Leu Thr Ser His  Ser Met Glu 
    1010                 1015                 1020             


Glu Cys  Glu Ala Leu Cys Thr  Arg Leu Ala Ile Met  Val Lys Gly 
    1025                 1030                 1035             


Ala Phe  Arg Cys Met Gly Thr  Ile Gln His Leu Lys  Ser Lys Phe 
    1040                 1045                 1050             


Gly Asp  Gly Tyr Ile Val Thr  Met Lys Ile Lys Ser  Pro Lys Asp 
    1055                 1060                 1065             


Asp Leu  Leu Pro Asp Leu Asn  Pro Val Glu Gln Phe  Phe Gln Gly 
    1070                 1075                 1080             


Asn Phe  Pro Gly Ser Val Gln  Arg Glu Arg His Tyr  Asn Met Leu 
    1085                 1090                 1095             


Gln Phe  Gln Val Ser Ser Ser  Ser Leu Ala Arg Ile  Phe Gln Leu 
    1100                 1105                 1110             


Leu Leu  Ser His Lys Asp Ser  Leu Leu Ile Glu Glu  Tyr Ser Val 
    1115                 1120                 1125             


Thr Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Gln 
    1130                 1135                 1140             


Gln Thr  Glu Ser His Asp Leu  Pro Leu His Pro Arg  Ala Ala Gly 
    1145                 1150                 1155             


Ala Ser  Arg Gln Ala Gln Asp  
    1160                 1165 


