                         SEQUENCE LISTING

<110>  Grace Science, LLC
 
<120>  Compositions and Methods for Treating NGYL1 Deficiency

<130>  38132.0001U1

<150>  US 63/180,065
<151>  2021-04-26

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
atggccgctg ctgccctggg atcatcaagt gggtccgctt cacctgccgt cgccgaactg       60

tgccagaaca cccccgaaac cttcctggag gcatccaagc tgctgctgac ctacgccgac      120

aacatcctgc gcaatccaaa cgatgagaag tatcgctcca tcaggatcgg caataccgcc      180

ttctctacaa ggctgctgcc cgtgagggga gcagtggagt gcctgttcga gatgggcttt      240

gaggagggcg agacacacct gatctttccc aagaaggcca gcgtggagca gctgcagaag      300

atcagggacc tgatcgccat cgagagaagc tcccggctgg atggctctaa caagagccac      360

aaggtgaagt ctagccagca gcctgcagca agcacacagc tgcctaccac accatcctct      420

aatccatccg gcctgaacca gcacaccagg aatagacagg gacagagctc cgacccacct      480

agcgcctcca cagtggcagc cgattctgcc atcctggagg tgctgcagag caacatccag      540

cacgtgctgg tgtacgagaa tccagccctg caggagaagg ccctggcatg catcccagtg      600

caggagctga agcggaagag ccaggagaag ctgtccaggg caaggaagct ggacaagggc      660

atcaatatca gcgacgagga tttcctgctg ctggagctgc tgcactggtt taaggaggag      720

ttctttcact gggtgaacaa tgtgctgtgc tccaagtgtg gcggccagac caggagcaga      780

gatcggtccc tgctgccttc tgacgatgag ctgaagtggg gcgccaagga ggtggaggac      840

cactactgcg atgcctgtca gttctccaac cgctttccca ggtataacaa tcctgagaag      900

ctgctggaga caagatgcgg ccggtgtggc gagtgggcca attgtttcac actgtgctgt      960

agagccgtgg gctttgaggc cagatacgtg tgggactata ccgatcacgt gtggacagag     1020

gtgtactctc ccagccagca gagatggctg cactgcgacg cctgtgagga cgtgtgcgat     1080

aagcctctgc tgtacgagat cggctggggc aagaagctgt cttatgtgat cgccttcagc     1140

aaggacgagg tggtggatgt gacctggcgg tatagctgta agcacgagga agtgatcgcc     1200

aggagaacca aggtgaagga ggccctgctg cgcgacacaa tcaatggcct gaacaagcag     1260

aggcagctgt tcctgtccga gaaccggcgc aaggagctgc tgcagaggat catcgtggag     1320

ctggtggagt ttatctctcc taagacccca aagccaggag agctgggagg aaggatctcc     1380

ggctctgtgg cctggcgcgt ggccaggggc gagatgggcc tgcagaggaa ggagacactg     1440

ttcatcccat gcgagaacga gaagatctct aagcagctgc acctgtgcta caatatcgtg     1500

aaggacagat atgtgcgggt gtccaacaat aaccagacca tctctggctg ggagaacggc     1560

gtgtggaaga tggagagcat ctttagaaag gtggagacag attggcacat ggtgtacctg     1620

gcccggaagg agggctctag cttcgcctat atcagctgga agtttgagtg tggctccgtg     1680

ggcctgaagg tggacagcat ctccatcaga acctcctctc agacattcca gaccggcaca     1740

gtggagtgga agctgaggtc cgataccgcc caggtggagc tgacaggcga caattccctg     1800

cactcttacg ccgatttctc tggcgccacc gaagtgatcc tggaggcaga gctgagcagg     1860

ggcgacggcg atgtggcctg gcagcacaca cagctgttta ggcagagcct gaacgaccac     1920

gaggagaatt gcctggagat tattatcaag ttttccgacc tgtga                     1965


<210>  2
<211>  259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt       60

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggcgcgc gccaggcggg      120

gcggggcggg gcgaggggcg gggcggggcg aggcggagag gtgcggcggc agccaatcag      180

agcggcgcgc tccgaaagtt tccttttatg gcgaggcggc ggcggcggcg gccctataaa      240

aagcgaagcg cgcggcggg                                                   259


<210>  3
<211>  382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt ac                                               382


<210>  4
<211>  658
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatgtcga ggacgcgtcc acgttctgct tcactctccc      420

catctccccc ccctccccac ccccaatttt gtatttattt attttttaat tattttgtgc      480

agcgatgggg gcgggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      540

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      600

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcggg        658


<210>  5
<211>  301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
tattgcggta gtttatcaca gttaaattgc taacgcagtc agtgcttctg acacaacagt       60

ctcgaactta agctgcagaa gttggtcgtg aggcactggg caggtaagta tcaaggttac      120

aagacaggtt taaggagacc aatagaaact gggcttgtcg agacagagaa gactcttgcg      180

tttctgatag gcacctattg gtcttactga catccacttt gcctttctct ccacaggcag      240

tgtccactcc cagttcaatt acagctctta aggctagagt acttaatacg actcactata      300

g                                                                      301


<210>  6
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  7
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210>  8
<211>  3677
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatgtcga ggacgcgtcc acgttctgct tcactctccc      420

catctccccc ccctccccac ccccaatttt gtatttattt attttttaat tattttgtgc      480

agcgatgggg gcgggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      540

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      600

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      660

ggagcaagct ttattgcggt agtttatcac agttaaattg ctaacgcagt cagtgcttct      720

gacacaacag tctcgaactt aagctgcaga agttggtcgt gaggcactgg gcaggtaagt      780

atcaaggtta caagacaggt ttaaggagac caatagaaac tgggcttgtc gagacagaga      840

agactcttgc gtttctgata ggcacctatt ggtcttactg acatccactt tgcctttctc      900

tccacaggca gtgtccactc ccagttcaat tacagctctt aaggctagag tacttaatac      960

gactcactat aggaattcgc caccatggcc gctgctgccc tgggatcatc aagtgggtcc     1020

gcttcacctg ccgtcgccga actgtgccag aacacccccg aaaccttcct ggaggcatcc     1080

aagctgctgc tgacctacgc cgacaacatc ctgcgcaatc caaacgatga gaagtatcgc     1140

tccatcagga tcggcaatac cgccttctct acaaggctgc tgcccgtgag gggagcagtg     1200

gagtgcctgt tcgagatggg ctttgaggag ggcgagacac acctgatctt tcccaagaag     1260

gccagcgtgg agcagctgca gaagatcagg gacctgatcg ccatcgagag aagctcccgg     1320

ctggatggct ctaacaagag ccacaaggtg aagtctagcc agcagcctgc agcaagcaca     1380

cagctgccta ccacaccatc ctctaatcca tccggcctga accagcacac caggaataga     1440

cagggacaga gctccgaccc acctagcgcc tccacagtgg cagccgattc tgccatcctg     1500

gaggtgctgc agagcaacat ccagcacgtg ctggtgtacg agaatccagc cctgcaggag     1560

aaggccctgg catgcatccc agtgcaggag ctgaagcgga agagccagga gaagctgtcc     1620

agggcaagga agctggacaa gggcatcaat atcagcgacg aggatttcct gctgctggag     1680

ctgctgcact ggtttaagga ggagttcttt cactgggtga acaatgtgct gtgctccaag     1740

tgtggcggcc agaccaggag cagagatcgg tccctgctgc cttctgacga tgagctgaag     1800

tggggcgcca aggaggtgga ggaccactac tgcgatgcct gtcagttctc caaccgcttt     1860

cccaggtata acaatcctga gaagctgctg gagacaagat gcggccggtg tggcgagtgg     1920

gccaattgtt tcacactgtg ctgtagagcc gtgggctttg aggccagata cgtgtgggac     1980

tataccgatc acgtgtggac agaggtgtac tctcccagcc agcagagatg gctgcactgc     2040

gacgcctgtg aggacgtgtg cgataagcct ctgctgtacg agatcggctg gggcaagaag     2100

ctgtcttatg tgatcgcctt cagcaaggac gaggtggtgg atgtgacctg gcggtatagc     2160

tgtaagcacg aggaagtgat cgccaggaga accaaggtga aggaggccct gctgcgcgac     2220

acaatcaatg gcctgaacaa gcagaggcag ctgttcctgt ccgagaaccg gcgcaaggag     2280

ctgctgcaga ggatcatcgt ggagctggtg gagtttatct ctcctaagac cccaaagcca     2340

ggagagctgg gaggaaggat ctccggctct gtggcctggc gcgtggccag gggcgagatg     2400

ggcctgcaga ggaaggagac actgttcatc ccatgcgaga acgagaagat ctctaagcag     2460

ctgcacctgt gctacaatat cgtgaaggac agatatgtgc gggtgtccaa caataaccag     2520

accatctctg gctgggagaa cggcgtgtgg aagatggaga gcatctttag aaaggtggag     2580

acagattggc acatggtgta cctggcccgg aaggagggct ctagcttcgc ctatatcagc     2640

tggaagtttg agtgtggctc cgtgggcctg aaggtggaca gcatctccat cagaacctcc     2700

tctcagacat tccagaccgg cacagtggag tggaagctga ggtccgatac cgcccaggtg     2760

gagctgacag gcgacaattc cctgcactct tacgccgatt tctctggcgc caccgaagtg     2820

atcctggagg cagagctgag caggggcgac ggcgatgtgg cctggcagca cacacagctg     2880

tttaggcaga gcctgaacga ccacgaggag aattgcctgg agattattat caagttttcc     2940

gacctgtgac tcgagaatca acctctggat tacaaaattt gtgaaagatt gactggtatt     3000

cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat     3060

gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct     3120

ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct     3180

gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc     3240

gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg     3300

acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc     3360

tttccttggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac     3420

gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg     3480

cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc     3540

ccgcatcgat gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     3600

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     3660

tttgtgtctc tcactcg                                                    3677


<210>  9
<211>  3972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgcct agtcgacatt gattattgac tagttattaa tagtaatcaa      180

ttacggggtc attagttcat agcccatata tggagttccg cgttacataa cttacggtaa      240

atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg      300

ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt      360

aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg      420

tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc      480

ctacttggca gtacatctac gtattagtca tcgctattac catgtcgagg acgcgtccac      540

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      600

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggcgcgcgcc aggcggggcg      660

gggcggggcg aggggcgggg cggggcgagg cggagaggtg cggcggcagc caatcagagc      720

ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc ggcggcggcc ctataaaaag      780

cgaagcgcgc ggcgggcggg agcaagcttt attgcggtag tttatcacag ttaaattgct      840

aacgcagtca gtgcttctga cacaacagtc tcgaacttaa gctgcagaag ttggtcgtga      900

ggcactgggc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg      960

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac     1020

atccactttg cctttctctc cacaggcagt gtccactccc agttcaatta cagctcttaa     1080

ggctagagta cttaatacga ctcactatag gaattcgcca ccatggccgc tgctgccctg     1140

ggatcatcaa gtgggtccgc ttcacctgcc gtcgccgaac tgtgccagaa cacccccgaa     1200

accttcctgg aggcatccaa gctgctgctg acctacgccg acaacatcct gcgcaatcca     1260

aacgatgaga agtatcgctc catcaggatc ggcaataccg ccttctctac aaggctgctg     1320

cccgtgaggg gagcagtgga gtgcctgttc gagatgggct ttgaggaggg cgagacacac     1380

ctgatctttc ccaagaaggc cagcgtggag cagctgcaga agatcaggga cctgatcgcc     1440

atcgagagaa gctcccggct ggatggctct aacaagagcc acaaggtgaa gtctagccag     1500

cagcctgcag caagcacaca gctgcctacc acaccatcct ctaatccatc cggcctgaac     1560

cagcacacca ggaatagaca gggacagagc tccgacccac ctagcgcctc cacagtggca     1620

gccgattctg ccatcctgga ggtgctgcag agcaacatcc agcacgtgct ggtgtacgag     1680

aatccagccc tgcaggagaa ggccctggca tgcatcccag tgcaggagct gaagcggaag     1740

agccaggaga agctgtccag ggcaaggaag ctggacaagg gcatcaatat cagcgacgag     1800

gatttcctgc tgctggagct gctgcactgg tttaaggagg agttctttca ctgggtgaac     1860

aatgtgctgt gctccaagtg tggcggccag accaggagca gagatcggtc cctgctgcct     1920

tctgacgatg agctgaagtg gggcgccaag gaggtggagg accactactg cgatgcctgt     1980

cagttctcca accgctttcc caggtataac aatcctgaga agctgctgga gacaagatgc     2040

ggccggtgtg gcgagtgggc caattgtttc acactgtgct gtagagccgt gggctttgag     2100

gccagatacg tgtgggacta taccgatcac gtgtggacag aggtgtactc tcccagccag     2160

cagagatggc tgcactgcga cgcctgtgag gacgtgtgcg ataagcctct gctgtacgag     2220

atcggctggg gcaagaagct gtcttatgtg atcgccttca gcaaggacga ggtggtggat     2280

gtgacctggc ggtatagctg taagcacgag gaagtgatcg ccaggagaac caaggtgaag     2340

gaggccctgc tgcgcgacac aatcaatggc ctgaacaagc agaggcagct gttcctgtcc     2400

gagaaccggc gcaaggagct gctgcagagg atcatcgtgg agctggtgga gtttatctct     2460

cctaagaccc caaagccagg agagctggga ggaaggatct ccggctctgt ggcctggcgc     2520

gtggccaggg gcgagatggg cctgcagagg aaggagacac tgttcatccc atgcgagaac     2580

gagaagatct ctaagcagct gcacctgtgc tacaatatcg tgaaggacag atatgtgcgg     2640

gtgtccaaca ataaccagac catctctggc tgggagaacg gcgtgtggaa gatggagagc     2700

atctttagaa aggtggagac agattggcac atggtgtacc tggcccggaa ggagggctct     2760

agcttcgcct atatcagctg gaagtttgag tgtggctccg tgggcctgaa ggtggacagc     2820

atctccatca gaacctcctc tcagacattc cagaccggca cagtggagtg gaagctgagg     2880

tccgataccg cccaggtgga gctgacaggc gacaattccc tgcactctta cgccgatttc     2940

tctggcgcca ccgaagtgat cctggaggca gagctgagca ggggcgacgg cgatgtggcc     3000

tggcagcaca cacagctgtt taggcagagc ctgaacgacc acgaggagaa ttgcctggag     3060

attattatca agttttccga cctgtgactc gagaatcaac ctctggatta caaaatttgt     3120

gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct     3180

ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat     3240

aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg     3300

gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag     3360

ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc     3420

tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg     3480

tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg gattctgcgc     3540

gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc     3600

ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc     3660

tccctttggg ccgcctcccc gcatcgatga tctttttccc tctgccaaaa attatgggga     3720

catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta ttttcattgc     3780

aatagtgtgt tggaattttt tgtgtctctc actcgcggac cgagcggccg caggaacccc     3840

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     3900

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     3960

gctgcctgca gg                                                         3972


<210>  10
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  11
<211>  3719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatgtcga ggacgcgtcc acgttctgct tcactctccc      420

catctccccc ccctccccac ccccaatttt gtatttattt attttttaat tattttgtgc      480

agcgatgggg gcgggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      540

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      600

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      660

ggagcaagct ttattgcggt agtttatcac agttaaattg ctaacgcagt cagtgcttct      720

gacacaacag tctcgaactt aagctgcaga agttggtcgt gaggcactgg gcaggtaagt      780

atcaaggtta caagacaggt ttaaggagac caatagaaac tgggcttgtc gagacagaga      840

agactcttgc gtttctgata ggcacctatt ggtcttactg acatccactt tgcctttctc      900

tccacaggca gtgtccactc ccagttcaat tacagctctt aaggctagag tacttaatac      960

gactcactat aggaattcgc caccatggct gcagctgcac tggggtcctc ttccggctcc     1020

gcttctcctg ctgttgctga actgtgtcaa aatacaccag aaacattttt agaagcatct     1080

aaattactgt taacatatgc cgataatata ctgagaaatc ccaatgacga aaagtataga     1140

tctattagaa ttggaaatac agctttttct actagactgt tacctgttag aggagccgtt     1200

gaatgtctgt ttgaaatggg attcgaagaa ggcgaaacac atctgatttt tcctaagaaa     1260

gcatcagttg aacaactgca aaaaattagg gacctgattg ccatagagag aagtagcaga     1320

ttagatggct ccaataagag ccacaaagta aagtcatccc agcaacctgc agcctccaca     1380

caactcccca caaccccatc ttcaaatcct agtggattaa atcaacatac aagaaataga     1440

caaggacaat cttctgatcc tccatctgct tcaactgtgg ctgctgattc tgctatttta     1500

gaagttctcc aatctaatat tcaacatgtt ctcgtttatg aaaatcctgc tttacaagaa     1560

aaagcattag cttgtatacc agtccaagaa ttaaaaagaa aatcacaaga aaaactctcc     1620

agagctagaa aattagataa aggtattaat ataagtgatg aagattttct gttgctggaa     1680

ttattgcatt ggtttaaaga agaatttttt cattgggtga ataatgtgtt atgttccaag     1740

tgtggaggac aaactagatc cagagataga tcattattac ctagtgatga tgaactgaaa     1800

tggggtgcca aagaggtgga ggatcactat tgtgatgctt gccaatttag caatagattt     1860

ccaagatata acaatcccga aaagttactg gaaacaagat gtggaagatg tggagaatgg     1920

gctaattgtt ttacactgtg ttgtagagct gtgggatttg aagctagata tgtttgggat     1980

tacacagacc atgtgtggac agaggtctat agcccttccc aacagagatg gctccactgt     2040

gatgcctgtg aggatgtgtg tgacaaaccc ttattatatg agataggatg gggaaagaaa     2100

ctgtcttatg tgattgcatt ctcaaaggat gaggtggtgg atgtcacctg gagatatagc     2160

tgtaaacatg aggaggtgat tgccagaaga accaaggtga aggaggcatt acttagagac     2220

accattaatg gacttaataa acagagacaa ctgtttctgt ccgaaaacag aagaaaagaa     2280

cttctccaga gaattattgt ggagttggtg gaatttatct ctcccaagac ccccaagcct     2340

ggagagctcg ggggaagaat ctctggatca gtggcctgga gagttgccag aggagagatg     2400

ggactgcaga gaaaggagac tctgttcatc ccctgtgaga atgagaagat ctctaaacag     2460

ctccacctgt gttacaatat tgtgaaagat agatatgtta gagtgtcaaa caacaatcag     2520

accatttctg gatgggagaa tggagtgtgg aaaatggaat ctatcttcag aaaagtggaa     2580

acagattggc atatggtgta tctggcaaga aaggaaggtt cctcttttgc ttacatctcc     2640

tggaagttcg agtgcgggtc tgttggactg aaagtggatt ctatctccat tagaacaagc     2700

agtcaaacct ttcagacagg aacagtggaa tggaaactga ggagcgatac agcccaagtg     2760

gaactgacag gagataactc cctccactcc tatgctgatt tttctggtgc cacagaagtg     2820

attctggaag cagaactgtc cagaggagat ggtgatgtgg cttggcaaca cacccagtta     2880

ttcagacaat ctctgaatga ccatgaggaa aactgtctgg agatcattat caaattcagt     2940

gacctgggta agcctatccc taaccctctc ctcggtctcg attctacgtg actcgagaat     3000

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     3060

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     3120

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg     3180

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     3240

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     3300

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     3360

ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg gctgctcgcc     3420

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     3480

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     3540

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcatcg atgatctttt     3600

tccctctgcc aaaaattatg gggacatcat gaagcccctt gagcatctga cttctggcta     3660

ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctcactcg      3719


