<110>    Kookmin University Industry Academy Cooperation Foundation

<120>    Antibody or antigen binding fragment thereof specifically binding
         to S protein of SARS-CoV-2 and Uses thereof

<130>    PP210046

<150>    KR 10-2021-0054590
<151>    2021-04-27

<150>    KR 10-2021-0054596
<151>    2021-04-27

<150>    KR 10-2021-0054600
<151>    2021-04-27

<150>    KR 10-2021-0054603
<151>    2021-04-27

<150>    KR 10-2021-0054606
<151>    2021-04-27

<160>    55

<170>    KoPatentIn 3.0

<210>    1
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG6 HCDR1


<400>    1
Gly Phe Thr Phe Ser Asp Tyr Ser Met Ser
  1               5                  10


<210>    2
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG6 HCDR2


<400>    2
Gly Ile Tyr His Ser Asp Gly Ser Lys Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    3
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG6 HCDR3


<400>    3
Phe Asp Pro Val Phe Asp Tyr
  1               5        


<210>    4
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG6 LCDR1


<400>    4
Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn Ala Val Asn
  1               5                  10            


<210>    5
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG6 LCDR2


<400>    5
Ala Asp Ser Asn Arg Pro Ser
  1               5        


<210>    6
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG6 LCDR3


<400>    6
Gly Ala Trp Asp Ala Ser Leu Ser Ala
  1               5                


<210>    7
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG6 VH


<400>    7
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Tyr His Ser Asp Gly Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Phe Asp Pro Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    8
<211>    110
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG6 VL


<400>    8
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ala Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ala Ser Leu
                 85                  90                  95 

Ser Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110


<210>    9
<211>    241
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RG6 scFv


<400>    9
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Tyr His Ser Asp Gly Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Phe Asp Pro Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125 

Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr
    130                 135                 140 

Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile
145                 150                 155                 160 

Gly Ser Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro
                165                 170                 175 

Lys Leu Leu Ile Tyr Ala Asp Ser Asn Arg Pro Ser Gly Val Pro Asp
            180                 185                 190 

Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser
        195                 200                 205 

Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp
    210                 215                 220 

Ala Ser Leu Ser Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val
225                 230                 235                 240 

Leu
   


<210>    10
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB4 HCDR1


<400>    10
Gly Phe Thr Phe Ser Asp Tyr Ser Met Ser
  1               5                  10


<210>    11
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB4 HCDR2


<400>    11
Gly Ile Tyr His Ser Asp Gly Ser Lys Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    12
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB4 HCDR3


<400>    12
Phe Asp Pro Val Phe Asp Tyr
  1               5        


<210>    13
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB4 LCDR1


<400>    13
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ala Val Ser
  1               5                  10            


<210>    14
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB4 LCDR2


<400>    14
Asp Asn Asn His Arg Pro Ser
  1               5        


<210>    15
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB4 LCDR3


<400>    15
Gly Ser Trp Asp Asp Ser Leu Asn Ala
  1               5                


<210>    16
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB4 VH


<400>    16
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Tyr His Ser Asp Gly Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Phe Asp Pro Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    17
<211>    110
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB4 VL


<400>    17
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Asp Asn Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Asp Ser Leu
                 85                  90                  95 

Asn Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110


<210>    18
<211>    241
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB4 scFv


<400>    18
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Tyr His Ser Asp Gly Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Phe Asp Pro Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125 

Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr
    130                 135                 140 

Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile
145                 150                 155                 160 

Gly Ser Asn Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro
                165                 170                 175 

Lys Leu Leu Ile Tyr Asp Asn Asn His Arg Pro Ser Gly Val Pro Asp
            180                 185                 190 

Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser
        195                 200                 205 

Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp
    210                 215                 220 

Asp Ser Leu Asn Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val
225                 230                 235                 240 

Leu
   


<210>    19
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB6 HCDR1


<400>    19
Gly Phe Thr Phe Ser Ser Tyr Asp Met Ser
  1               5                  10


<210>    20
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB6 HCDR2


<400>    20
Gly Ile Ser Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    21
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB6 HCDR3


<400>    21
Asp Val Asn Phe Val Pro Leu Val Thr Phe Asp Tyr
  1               5                  10        


<210>    22
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB6 LCDR1


<400>    22
Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn Ser Val Thr
  1               5                  10            


<210>    23
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB6 LCDR2


<400>    23
Asp Asp Asn Gln Arg Pro Ser
  1               5        


<210>    24
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB6 LCDR3


<400>    24
Gly Thr Trp Asp Tyr Ser Leu Ser Ala
  1               5                


<210>    25
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB6 VH


<400>    25
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Val Asn Phe Val Pro Leu Val Thr Phe Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120    


<210>    26
<211>    110
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB6 VL


<400>    26
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Leu Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Ser Val Thr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Asp Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Tyr Ser Leu
                 85                  90                  95 

Ser Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110


<210>    27
<211>    246
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RB6 scFv


<400>    27
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Val Asn Phe Val Pro Leu Val Thr Phe Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125 

Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro
    130                 135                 140 

Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Leu Ser Cys Thr Gly
145                 150                 155                 160 

Ser Ser Ser Asn Ile Gly Ser Asn Ser Val Thr Trp Tyr Gln Gln Leu
                165                 170                 175 

Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asp Asn Gln Arg Pro
            180                 185                 190 

Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala
        195                 200                 205 

Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr
    210                 215                 220 

Cys Gly Thr Trp Asp Tyr Ser Leu Ser Ala Tyr Val Phe Gly Gly Gly
225                 230                 235                 240 

Thr Lys Leu Thr Val Leu
                245    


<210>    28
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD3 HCDR1


<400>    28
Gly Phe Thr Phe Ser Asp Tyr Ala Met Ser
  1               5                  10


<210>    29
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD3 HCDR2


<400>    29
Trp Ile Tyr Ser Gly Ser Gly Asn Lys Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    30
<211>    18
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD3 HCDR3


<400>    30
Phe Pro Ile Ala Arg Thr Ser Asn Ser Gln Ser Ser Tyr Asp Gly Met
  1               5                  10                  15 

Asp Val
       


<210>    31
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD3 LCDR1


<400>    31
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ala Val Ser
  1               5                  10            


<210>    32
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD3 LCDR2


<400>    32
Ala Asp Asn Lys Arg Pro Ser
  1               5        


<210>    33
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD3 LCDR3


<400>    33
Gly Ala Trp Asp Ser Ser Leu Asn Ala
  1               5                


<210>    34
<211>    127
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD3 VH


<400>    34
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Trp Ile Tyr Ser Gly Ser Gly Asn Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Phe Pro Ile Ala Arg Thr Ser Asn Ser Gln Ser Ser Tyr Asp
            100                 105                 110 

Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 




<210>    35
<211>    110
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD3 VL


<400>    35
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ala Asp Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Ser Leu
                 85                  90                  95 

Asn Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110


<210>    36
<211>    252
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD3 scFv


<400>    36
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Trp Ile Tyr Ser Gly Ser Gly Asn Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Phe Pro Ile Ala Arg Thr Ser Asn Ser Gln Ser Ser Tyr Asp
            100                 105                 110 

Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly
        115                 120                 125 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser
    130                 135                 140 

Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val
145                 150                 155                 160 

Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ala Val
                165                 170                 175 

Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr
            180                 185                 190 

Ala Asp Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser
        195                 200                 205 

Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu
    210                 215                 220 

Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Ser Leu Asn Ala
225                 230                 235                 240 

Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
                245                 250        


<210>    37
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD10 HCDR1


<400>    37
Gly Phe Thr Phe Ser Asp Tyr Ala Met Ser
  1               5                  10


<210>    38
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD10 HCDR2


<400>    38
Ala Ile Tyr Pro Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    39
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD10 HCDR3


<400>    39
Asn Leu Phe Gly Phe Asp Tyr
  1               5        


<210>    40
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD10 LCDR1


<400>    40
Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn Ala Val Tyr
  1               5                  10            


<210>    41
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD10 LCDR2


<400>    41
Asp Asp Ser Asn Arg Pro Ser
  1               5        


<210>    42
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD10 LCDR3


<400>    42
Gly Ser Trp Asp Asp Ser Leu Ser Ala
  1               5                


<210>    43
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD10 VH


<400>    43
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Tyr Pro Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asn Leu Phe Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    44
<211>    110
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD10 VL


<400>    44
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Ala Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Asp Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110


<210>    45
<211>    241
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    RD10 scFv


<400>    45
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Tyr Pro Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asn Leu Phe Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125 

Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr
    130                 135                 140 

Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile
145                 150                 155                 160 

Gly Ser Asn Ala Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro
                165                 170                 175 

Lys Leu Leu Ile Tyr Asp Asp Ser Asn Arg Pro Ser Gly Val Pro Asp
            180                 185                 190 

Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser
        195                 200                 205 

Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp
    210                 215                 220 

Asp Ser Leu Ser Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val
225                 230                 235                 240 

Leu
   


<210>    46
<211>    723
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Nucleotide sequence of RG6 scFv


<400>    46
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc         60

tcctgtgcag cctctggatt cacctttagc gattattcta tgagctgggt ccgccaggct        120

ccagggaagg ggctggagtg ggtctcaggg atctatcata gtgatggtag taaatattac        180

gctgattctg taaaaggtcg gttcaccatc tccagagaca attccaagaa cacgctgtat        240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagatttgat        300

cctgttttcg actactgggg ccagggtaca ctggtcaccg tgagctcagg tggaggcggt        360

tcaggcggag gtggatccgg cggtggcgga tcgcagtctg tgctgactca gccaccctca        420

gcgtctggga cccccgggca gagggtcacc atctcttgta ctggctcttc atctaatatt        480

ggcagtaatg ctgtcaactg gtaccagcag ctcccaggaa cggcccccaa actcctcatc        540

tatgctgata gtaatcggcc aagcggggtc cctgaccgat tctctggctc caagtctggc        600

acctcagcct ccctggccat cagtgggctc cggtccgagg atgaggctga ttattactgt        660

ggtgcttggg atgctagcct gagtgcttat gtcttcggcg gaggcaccaa gctgacggtc        720

cta                                                                      723


<210>    47
<211>    723
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Nucleotide sequence of RB4scFv


<400>    47
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc         60

tcctgtgcag cctctggatt cacctttagc gattattcta tgagctgggt ccgccaggct        120

ccagggaagg ggctggagtg ggtctcaggg atctatcata gtgatggtag taaatattac        180

gctgattctg taaaaggtcg gttcaccatc tccagagaca attccaagaa cacgctgtat        240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagatttgat        300

cctgttttcg actactgggg ccagggtaca ctggtcaccg tgagctcagg tggaggcggt        360

tcaggcggag gtggatccgg cggtggcgga tcgcagtctg tgctgactca gccaccctca        420

gcgtctggga cccccgggca gagggtcacc atctcttgta gtggctcttc atctaatatt        480

ggcagtaatg ctgtctcctg gtaccagcag ctcccaggaa cggcccccaa actcctcatc        540

tatgataata atcatcggcc aagcggggtc cctgaccgat tctctggctc caagtctggc        600

acctcagcct ccctggccat cagtgggctc cggtccgagg atgaggctga ttattactgt        660

ggttcttggg atgatagcct gaatgcttat gtcttcggcg gaggcaccaa gctgacggtc        720

cta                                                                      723


<210>    48
<211>    738
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Nucleotide sequence of RB6 scFv


<400>    48
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc         60

tcctgtgcag cctctggatt cacctttagc agttatgata tgagctgggt ccgccaggct        120

ccagggaagg ggctggagtg ggtctcaggg atctcttata gtggtggtag tacatattac        180

gctgattctg taaaaggtcg gttcaccatc tccagagaca attccaagaa cacgctgtat        240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagatgtt        300

aattttgttc cgttggttac gttcgactac tggggccagg gtacactggt caccgtgagc        360

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcgca gtctgtgctg        420

actcagccac cctcagcgtc tgggaccccc gggcagaggg tcaccctctc ttgtactggc        480

tcttcatcta atattggcag taattctgtc acctggtacc agcagctccc aggaacggcc        540

cccaaactcc tcatctatga tgataatcag cggccgagcg gggtccctga ccgattctct        600

ggctccaagt ctggcacctc agcctccctg gccatcagtg ggctccggtc cgaggatgag        660

gctgattatt actgtggtac ttgggattat agcctgagtg cttatgtctt cggcggaggc        720

accaagctga cggtccta                                                      738


<210>    49
<211>    756
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Nucleotide sequence of RD3 scFv


<400>    49
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc         60

tcctgtgcag cctctggatt cacctttagc gattatgcta tgagctgggt ccgccaggct        120

ccagggaaag ggctggagtg ggtctcatgg atctattctg gtagtggtaa taaatattac        180

gctgattctg taaaaggtcg gttcaccatc tccagagaca attccaagaa cacgctgtat        240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagatttcct        300

attgctcgta cttctaatag tcagtcttct tatgatggta tggacgtctg gggccagggt        360

acactggtca ccgtgagctc aggtggaggc ggttcaggcg gaggtggatc cggcggtggc        420

ggatcgcagt ctgtgctgac tcagccaccc tcagcgtctg ggacccccgg gcagagggtc        480

accatctctt gtagtggctc ttcatctaat attggcagta atgctgtctc ctggtaccag        540

cagctcccag gaacggcccc caaactcctc atctatgctg ataataagcg gccaagcggg        600

gtccctgacc gattctctgg ctccaagtct ggcacctcag cctccctggc catcagtggg        660

ctccggtccg aggatgaggc tgattattac tgtggtgctt gggattctag cctgaatgct        720

tatgtcttcg gcggaggcac caagctgacg gtccta                                  756


<210>    50
<211>    723
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Nucleotide sequence of RD10 scFv


<400>    50
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc         60

tcctgtgcag cctctggatt cacctttagc gattatgcta tgagctgggt ccgccaggct        120

ccagggaagg ggctggagtg ggtctcagcg atctatcctg gtggtggtag tacatattac        180

gctgattctg taaaaggtcg gttcaccatc tccagagaca attccaagaa cacgctgtat        240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagaaatctg        300

tttgggttcg actactgggg ccagggtaca ctggtcaccg tgagctcagg tggaggcggt        360

tcaggcggag gtggatccgg cggtggcgga tcgcagtctg tgctgactca gccaccctca        420

gcgtctggga cccccgggca gagggtcacc atctcttgta ctggctcttc atctaatatt        480

ggcagtaatg ctgtctactg gtaccagcag ctcccaggaa cggcccccaa actcctcatc        540

tatgatgata gtaatcggcc aagcggggtc cctgaccgat tctctggctc caagtctggc        600

acctcagcct ccctggccat cagtgggctc cggtccgagg atgaggctga ttattactgt        660

ggttcttggg atgatagcct gagtgcttat gtcttcggcg gaggcaccaa gctgacggtc        720

cta                                                                      723


<210>    51
<211>    157
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    S-RBD


<400>    51
Arg Val Thr Ser Val Arg Asn Thr Asn Cys Gly Val Asn Ala Thr Arg
  1               5                  10                  15 

Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ser Asn Cys Val Ala Asp
             20                  25                  30 

Tyr Ser Val Tyr Asn Ser Ala Ser Ser Thr Lys Cys Tyr Gly Val Ser
         35                  40                  45 

Thr Lys Asn Asp Cys Thr Asn Val Tyr Ala Asp Ser Val Arg Gly Asp
     50                  55                  60 

Val Arg Ala Gly Thr Gly Lys Ala Asp Tyr Asn Tyr Lys Asp Asp Thr
 65                  70                  75                  80 

Gly Cys Val Ala Trp Asn Ser Asn Asn Asp Ser Lys Val Gly Gly Asn
                 85                  90                  95 

Tyr Asn Tyr Tyr Arg Arg Lys Ser Asn Lys Arg Asp Ser Thr Tyr Ala
            100                 105                 110 

Gly Ser Thr Cys Asn Gly Val Gly Asn Cys Tyr Ser Tyr Gly Thr Asn
        115                 120                 125 

Gly Val Gly Tyr Tyr Arg Val Val Val Ser His Ala Ala Thr Val Cys
    130                 135                 140 

Gly Lys Lys Ser Thr Asn Val Lys Asn Lys Cys Val Asn
145                 150                 155        


<210>    52
<211>    458
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    S1 domain


<400>    52
Ser Cys Val Asn Thr Thr Arg Thr Ala Tyr Thr Asn Ser Thr Arg Gly
  1               5                  10                  15 

Val Tyr Tyr Asp Lys Val Arg Ser Ser Val His Ser Thr Asp Ser Asn
             20                  25                  30 

Val Thr Trp His Ala His Val Ser Gly Thr Asn Gly Thr Lys Arg Asp
         35                  40                  45 

Asn Val Asn Asp Gly Val Tyr Ala Ser Thr Lys Ser Asn Arg Gly Trp
     50                  55                  60 

Gly Thr Thr Asp Ser Lys Thr Ser Val Asn Asn Ala Thr Asn Val Val
 65                  70                  75                  80 

Lys Val Cys Cys Asn Asp Gly Val Tyr Tyr His Lys Asn Asn Lys Ser
                 85                  90                  95 

Trp Met Ser Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Tyr Val Ser
            100                 105                 110 

Met Asp Gly Lys Gly Asn Lys Asn Arg Val Lys Asn Asp Gly Tyr Lys
        115                 120                 125 

Tyr Ser Lys His Thr Asn Val Arg Asp Gly Ser Ala Val Asp Gly Asn
    130                 135                 140 

Thr Arg Thr Ala His Arg Ser Tyr Thr Gly Asp Ser Ser Ser Gly Trp
145                 150                 155                 160 

Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Arg Thr Lys Tyr Asn
                165                 170                 175 

Asn Gly Thr Thr Asp Ala Val Asp Cys Ala Asp Ser Thr Lys Cys Thr
            180                 185                 190 

Lys Ser Thr Val Lys Gly Tyr Thr Ser Asn Arg Val Thr Ser Val Arg
        195                 200                 205 

Asn Thr Asn Cys Gly Val Asn Ala Thr Arg Ala Ser Val Tyr Ala Trp
    210                 215                 220 

Asn Arg Lys Arg Ser Asn Cys Val Ala Asp Tyr Ser Val Tyr Asn Ser
225                 230                 235                 240 

Ala Ser Ser Thr Lys Cys Tyr Gly Val Ser Thr Lys Asn Asp Cys Thr
                245                 250                 255 

Asn Val Tyr Ala Asp Ser Val Arg Gly Asp Val Arg Ala Gly Thr Gly
            260                 265                 270 

Lys Ala Asp Tyr Asn Tyr Lys Asp Asp Thr Gly Cys Val Ala Trp Asn
        275                 280                 285 

Ser Asn Asn Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Tyr Arg Arg
    290                 295                 300 

Lys Ser Asn Lys Arg Asp Ser Thr Tyr Ala Gly Ser Thr Cys Asn Gly
305                 310                 315                 320 

Val Gly Asn Cys Tyr Ser Tyr Gly Thr Asn Gly Val Gly Tyr Tyr Arg
                325                 330                 335 

Val Val Val Ser His Ala Ala Thr Val Cys Gly Lys Lys Ser Thr Asn
            340                 345                 350 

Val Lys Asn Lys Cys Val Asn Asn Asn Gly Thr Gly Thr Gly Val Thr
        355                 360                 365 

Ser Asn Lys Lys Gly Arg Asp Ala Asp Thr Thr Asp Ala Val Arg Asp
    370                 375                 380 

Thr Asp Thr Cys Ser Gly Gly Val Ser Val Thr Gly Thr Asn Thr Ser
385                 390                 395                 400 

Asn Val Ala Val Tyr Asp Val Asn Cys Thr Val Val Ala His Ala Asp
                405                 410                 415 

Thr Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Thr Arg Ala Gly
            420                 425                 430 

Cys Gly Ala His Val Asn Asn Ser Tyr Cys Asp Gly Ala Gly Cys Ala
        435                 440                 445 

Ser Tyr Thr Thr Asn Ser Arg Arg Ala Arg
    450                 455            


<210>    53
<211>    381
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    S2 domain


<400>    53
Ser Val Ala Ser Ser Ala Tyr Thr Met Ser Gly Ala Asn Ser Val Ala
  1               5                  10                  15 

Tyr Ser Asn Asn Ser Ala Thr Asn Thr Ser Val Thr Thr Val Ser Met
             20                  25                  30 

Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Cys Gly Asp Ser Thr Cys
         35                  40                  45 

Ser Asn Tyr Gly Ser Cys Thr Asn Arg Ala Thr Gly Ala Val Asp Lys
     50                  55                  60 

Asn Thr Val Ala Val Lys Tyr Lys Thr Lys Asp Gly Gly Asn Ser Asp
 65                  70                  75                  80 

Ser Lys Ser Lys Arg Ser Asp Asn Lys Val Thr Ala Asp Ala Gly Lys
                 85                  90                  95 

Tyr Gly Asp Cys Gly Asp Ala Ala Arg Asp Cys Ala Lys Asn Gly Thr
            100                 105                 110 

Val Thr Asp Met Ala Tyr Thr Ser Ala Ala Gly Thr Thr Ser Gly Trp
        115                 120                 125 

Thr Gly Ala Gly Ala Ala Ala Met Met Ala Tyr Arg Asn Gly Gly Val
    130                 135                 140 

Thr Asn Val Tyr Asn Lys Ala Asn Asn Ser Ala Gly Lys Asp Ser Ser
145                 150                 155                 160 

Ser Thr Ala Ser Ala Gly Lys Asp Val Val Asn Asn Ala Ala Asn Thr
                165                 170                 175 

Val Lys Ser Ser Asn Gly Ala Ser Ser Val Asn Asp Ser Arg Asp Lys
            180                 185                 190 

Val Ala Val Asp Arg Thr Gly Arg Ser Thr Tyr Val Thr Arg Ala Ala
        195                 200                 205 

Arg Ala Ser Ala Asn Ala Ala Thr Lys Met Ser Cys Val Gly Ser Lys
    210                 215                 220 

Arg Val Asp Cys Gly Lys Gly Tyr His Met Ser Ser Ala His Gly Val
225                 230                 235                 240 

Val His Val Thr Tyr Val Ala Lys Asn Thr Thr Ala Ala Cys His Asp
                245                 250                 255 

Gly Lys Ala His Arg Gly Val Val Ser Asn Gly Thr His Trp Val Thr
            260                 265                 270 

Arg Asn Tyr Thr Thr Asp Asn Thr Val Ser Gly Asn Cys Asp Val Val
        275                 280                 285 

Gly Val Asn Asn Thr Val Tyr Asp Asp Ser Lys Asp Lys Tyr Lys Asn
    290                 295                 300 

His Thr Ser Asp Val Asp Gly Asp Ser Gly Asn Ala Ser Val Val Asn
305                 310                 315                 320 

Lys Asp Arg Asn Val Ala Lys Asn Asn Ser Asp Gly Lys Tyr Tyr Lys
                325                 330                 335 

Trp Trp Tyr Trp Gly Ala Gly Ala Val Met Val Thr Met Cys Cys Met
            340                 345                 350 

Thr Ser Cys Cys Ser Cys Lys Gly Cys Cys Ser Cys Gly Ser Cys Cys
        355                 360                 365 

Lys Asp Asp Asp Ser Val Lys Gly Val Lys His Tyr Thr
    370                 375                 380 




<210>    54
<211>    844
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Full-length S protein


<400>    54
Met Val Val Val Ser Ser Cys Val Asn Thr Thr Arg Thr Ala Tyr Thr
  1               5                  10                  15 

Asn Ser Thr Arg Gly Val Tyr Tyr Asp Lys Val Arg Ser Ser Val His
             20                  25                  30 

Ser Thr Asp Ser Asn Val Thr Trp His Ala His Val Ser Gly Thr Asn
         35                  40                  45 

Gly Thr Lys Arg Asp Asn Val Asn Asp Gly Val Tyr Ala Ser Thr Lys
     50                  55                  60 

Ser Asn Arg Gly Trp Gly Thr Thr Asp Ser Lys Thr Ser Val Asn Asn
 65                  70                  75                  80 

Ala Thr Asn Val Val Lys Val Cys Cys Asn Asp Gly Val Tyr Tyr His
                 85                  90                  95 

Lys Asn Asn Lys Ser Trp Met Ser Arg Val Tyr Ser Ser Ala Asn Asn
            100                 105                 110 

Cys Thr Tyr Val Ser Met Asp Gly Lys Gly Asn Lys Asn Arg Val Lys
        115                 120                 125 

Asn Asp Gly Tyr Lys Tyr Ser Lys His Thr Asn Val Arg Asp Gly Ser
    130                 135                 140 

Ala Val Asp Gly Asn Thr Arg Thr Ala His Arg Ser Tyr Thr Gly Asp
145                 150                 155                 160 

Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr
                165                 170                 175 

Arg Thr Lys Tyr Asn Asn Gly Thr Thr Asp Ala Val Asp Cys Ala Asp
            180                 185                 190 

Ser Thr Lys Cys Thr Lys Ser Thr Val Lys Gly Tyr Thr Ser Asn Arg
        195                 200                 205 

Val Thr Ser Val Arg Asn Thr Asn Cys Gly Val Asn Ala Thr Arg Ala
    210                 215                 220 

Ser Val Tyr Ala Trp Asn Arg Lys Arg Ser Asn Cys Val Ala Asp Tyr
225                 230                 235                 240 

Ser Val Tyr Asn Ser Ala Ser Ser Thr Lys Cys Tyr Gly Val Ser Thr
                245                 250                 255 

Lys Asn Asp Cys Thr Asn Val Tyr Ala Asp Ser Val Arg Gly Asp Val
            260                 265                 270 

Arg Ala Gly Thr Gly Lys Ala Asp Tyr Asn Tyr Lys Asp Asp Thr Gly
        275                 280                 285 

Cys Val Ala Trp Asn Ser Asn Asn Asp Ser Lys Val Gly Gly Asn Tyr
    290                 295                 300 

Asn Tyr Tyr Arg Arg Lys Ser Asn Lys Arg Asp Ser Thr Tyr Ala Gly
305                 310                 315                 320 

Ser Thr Cys Asn Gly Val Gly Asn Cys Tyr Ser Tyr Gly Thr Asn Gly
                325                 330                 335 

Val Gly Tyr Tyr Arg Val Val Val Ser His Ala Ala Thr Val Cys Gly
            340                 345                 350 

Lys Lys Ser Thr Asn Val Lys Asn Lys Cys Val Asn Asn Asn Gly Thr
        355                 360                 365 

Gly Thr Gly Val Thr Ser Asn Lys Lys Gly Arg Asp Ala Asp Thr Thr
    370                 375                 380 

Asp Ala Val Arg Asp Thr Asp Thr Cys Ser Gly Gly Val Ser Val Thr
385                 390                 395                 400 

Gly Thr Asn Thr Ser Asn Val Ala Val Tyr Asp Val Asn Cys Thr Val
                405                 410                 415 

Val Ala His Ala Asp Thr Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn
            420                 425                 430 

Val Thr Arg Ala Gly Cys Gly Ala His Val Asn Asn Ser Tyr Cys Asp
        435                 440                 445 

Gly Ala Gly Cys Ala Ser Tyr Thr Thr Asn Ser Arg Arg Ala Arg Ser
    450                 455                 460 

Val Ala Ser Ser Ala Tyr Thr Met Ser Gly Ala Asn Ser Val Ala Tyr
465                 470                 475                 480 

Ser Asn Asn Ser Ala Thr Asn Thr Ser Val Thr Thr Val Ser Met Thr
                485                 490                 495 

Lys Thr Ser Val Asp Cys Thr Met Tyr Cys Gly Asp Ser Thr Cys Ser
            500                 505                 510 

Asn Tyr Gly Ser Cys Thr Asn Arg Ala Thr Gly Ala Val Asp Lys Asn
        515                 520                 525 

Thr Val Ala Val Lys Tyr Lys Thr Lys Asp Gly Gly Asn Ser Asp Ser
    530                 535                 540 

Lys Ser Lys Arg Ser Asp Asn Lys Val Thr Ala Asp Ala Gly Lys Tyr
545                 550                 555                 560 

Gly Asp Cys Gly Asp Ala Ala Arg Asp Cys Ala Lys Asn Gly Thr Val
                565                 570                 575 

Thr Asp Met Ala Tyr Thr Ser Ala Ala Gly Thr Thr Ser Gly Trp Thr
            580                 585                 590 

Gly Ala Gly Ala Ala Ala Met Met Ala Tyr Arg Asn Gly Gly Val Thr
        595                 600                 605 

Asn Val Tyr Asn Lys Ala Asn Asn Ser Ala Gly Lys Asp Ser Ser Ser
    610                 615                 620 

Thr Ala Ser Ala Gly Lys Asp Val Val Asn Asn Ala Ala Asn Thr Val
625                 630                 635                 640 

Lys Ser Ser Asn Gly Ala Ser Ser Val Asn Asp Ser Arg Asp Lys Val
                645                 650                 655 

Ala Val Asp Arg Thr Gly Arg Ser Thr Tyr Val Thr Arg Ala Ala Arg
            660                 665                 670 

Ala Ser Ala Asn Ala Ala Thr Lys Met Ser Cys Val Gly Ser Lys Arg
        675                 680                 685 

Val Asp Cys Gly Lys Gly Tyr His Met Ser Ser Ala His Gly Val Val
    690                 695                 700 

His Val Thr Tyr Val Ala Lys Asn Thr Thr Ala Ala Cys His Asp Gly
705                 710                 715                 720 

Lys Ala His Arg Gly Val Val Ser Asn Gly Thr His Trp Val Thr Arg
                725                 730                 735 

Asn Tyr Thr Thr Asp Asn Thr Val Ser Gly Asn Cys Asp Val Val Gly
            740                 745                 750 

Val Asn Asn Thr Val Tyr Asp Asp Ser Lys Asp Lys Tyr Lys Asn His
        755                 760                 765 

Thr Ser Asp Val Asp Gly Asp Ser Gly Asn Ala Ser Val Val Asn Lys
    770                 775                 780 

Asp Arg Asn Val Ala Lys Asn Asn Ser Asp Gly Lys Tyr Tyr Lys Trp
785                 790                 795                 800 

Trp Tyr Trp Gly Ala Gly Ala Val Met Val Thr Met Cys Cys Met Thr
                805                 810                 815 

Ser Cys Cys Ser Cys Lys Gly Cys Cys Ser Cys Gly Ser Cys Cys Lys
            820                 825                 830 

Asp Asp Asp Ser Val Lys Gly Val Lys His Tyr Thr
        835                 840                


<210>    55
<211>    222
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SARS-CoV S-RBD sequence


<400>    55
Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn
  1               5                  10                  15 

Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val
             20                  25                  30 

Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser
         35                  40                  45 

Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val
     50                  55                  60 

Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp
 65                  70                  75                  80 

Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln
                 85                  90                  95 

Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met
            100                 105                 110 

Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr
        115                 120                 125 

Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg
    130                 135                 140 

Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys
145                 150                 155                 160 

Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr
                165                 170                 175 

Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val
            180                 185                 190 

Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro
        195                 200                 205 

Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe
    210                 215                 220 


