                         SEQUENCE LISTING

<110>  GENEVANT SCIENCES GMBH
 
<120>  MRNA DELIVERY CONSTRUCTS AND METHODS OF USING THE SAME

<130>  4170.023PC01

<150>  63/181,115
<151>  2021-04-28

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  47
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5' UTR

<400>  1
aggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  2
<211>  114
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' UTR

<400>  2
gcggccgcuu aauuaagcug ccuucugcgg ggcuugccuu cuggccaugc ccuucuucuc       60

ucccuugcac cuguaccucu uggucuuuga auaaagccug aguaggaagu cuag            114


<210>  3
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7 Promoter

<400>  3
taatacgact cactata                                                      17


<210>  4
<211>  582
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hEPO ORF

<400>  4
gacagccggg ugcuggagcg guaccugcug gaggccaagg aggccgagaa caucaccacc       60

ggcugcgccg agcacugcag ccugaacgag aacaucaccg ugcccgacac caaggugaac      120

uucuacgccu ggaagcggau ggaggugggc cagcaggccg uggaggugug gcagggccug      180

gcccugcuga gcgaggccgu gcugcggggc caggcccugc uggugaacag cagccagccc      240

ugggagcccc ugcagcugca cguggacaag gccgugagcg gccugcggag ccugaccacc      300

cugcugcggg cccugggcgc ccagaaggag gccaucagcc cccccgacgc cgccagcgcc      360

gccccccugc ggaccaucac cgccgacacc uuccggaagc uguuccgggu guacagcaac      420

uuccugcggg gcaagcugaa gcuguacacc ggcgaggccu gccggaccgg cgaccgguga      480

augggcgugc acgagugccc cgccuggcug uggcugcugc ugagccugcu gagccugccc      540

cugggccugc ccgugcuggg cgcccccccc cggcugaucu gc                         582


<210>  5
<211>  1404
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hMMP-8 ORF

<400>  5
auguucagcc uuaaaacccu gccuuuccug cugcugcugc acgugcagau cuccaaggcc       60

uuucccgugu ccagcaagga gaagaacacc aagaccgugc aggacuaccu ggaaaaguuc      120

uaccagcugc cuagcaauca auaccagagc acccgcaaga acgguacaaa cgugaucgug      180

gaaaagcuga aggaaaugca gagauucuuc ggccugaacg ugacaggcaa gccuaacgag      240

gaaacacugg acaugaugaa aaagccaaga uguggcgugc ccgacagcgg cggcuuuaug      300

cugacaccug gaaauccuaa gugggagcgg accaaucuga ccuacagaau ccggaacuac      360

accccucagc ucuccgaggc cgagguggaa agagccauua aggacgccuu cgagcugugg      420

uccguggcau cuccucugau uuucaccaga aucagccagg gcgaggccga caucaacauc      480

gccuucuacc agcgggacca cggcgauaac agccccuucg acggccccaa uggcauccuc      540

gcccacgccu uucagccugg acagggcaua ggaggagaug cucauuucga cgcugaggaa      600

accuggacaa auaccagcgc caacuacaac cuguuccugg uggccgccca cgaguucggc      660

cacagccugg gccuggccca cagcagcgac cccggagccc ugauguaccc caacuacgcc      720

uuccgggaaa caagcaacua cagccugccu caagacgaca ucgacggcau ccaggccauc      780

uacggccuga gcucuaaccc cauccagccu acaggcccau cuaccccuaa gccaugugau      840

ccuagccuga ccuucgaugc caucacgacc cugagaggag agauccuguu uuuuaaggac      900

agauacuucu ggcggagaca cccucagcug cagcggguug aaaugaacuu caucagccug      960

uucuggccuu cucugcccac cggcauccag gcugccuacg aggacuucga ccgggaccug     1020

aucuuccugu ucaagggcaa ccaguacugg gcccugagcg gauaugacau ccugcagggc     1080

uacccuaaag auaucagcaa cuacggcuuc ccuagcagcg ugcaagccau cgacgccgcu     1140

guguucuacc ggagcaaaac cuacuucuuc gugaacgacc aguucuggag auacgacaac     1200

cagagacagu uuauggaacc cggcuauccu aagagcaucu cuggcgccuu ccccggcauc     1260

gagagcaagg uggacgccgu guuccagcag gagcacuucu uccacguguu cucuggcccu     1320

agauacuacg ccuuugaucu gaucgcccag agggugacca gaguggccag aggcaacaag     1380

uggcugaacu gcagauaugg cuga                                            1404


<210>  6
<211>  1161
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  2-M9 Wildtype ORF

<400>  6
augggcucca ucggcgcagc aagcauggaa uuuuguuuug auguauucaa ggagcucaaa       60

guccaccaug ccaaugagaa caucuucuac ugccccauug ccaucauguc agcucuagcc      120

augguauacc ugggugcaaa agacagcacc aggacacaga uaaauaaggu uguucgcuuu      180

gauaaacuuc caggauucgg agacaguauu gaagcucagu guggcacauc uguaaacguu      240

cacucuucac uuagagacau ccucaaccaa aucaccaaac caaaugaugu uuauucguuc      300

agccuugcca guagacuuua ugcugaagag agauacccaa uccugccaga auacuugcag      360

ugugugaagg aacuguauag aggaggcuug gaaccuauca acuuucaaac agcugcagau      420

caagccagag agcucaucaa uuccugggua gaaagucaga caaauggaau uaucagaaau      480

guccuucagc caagcuccgu ggauucucaa acugcaaugg uucugguuaa ugccauuguc      540

uucaaaggac ugugggagaa aacauuuaag gaugaagaca cacaagcaau gccuuucaga      600

gugacugagc aagaaagcaa accugugcag augauguacc agauugguuu auuuagagug      660

gcaucaaugg cuucugagaa aaugaagauc cuggagcuuc cauuugccag ugggacaaug      720

agcauguugg ugcuguugcc ugaugaaguc ucaggccuug agcagcuuga gaguauaauc      780

aacuuugaaa aacugacuga auggaccagu ucuaauguua uggaagagag gaagaucaaa      840

guguacuuac cucgcaugaa gauggaggaa aaauacaacc ucacaucugu cuuaauggcu      900

augggcauua cugacguguu uagcucuuca gccaaucugu cuggcaucuc cucagcagag      960

agccugaaga uaucucaagc uguccaugca gcacaugcag aaaucaauga agcaggcaga     1020

gaggugguag ggucagcaga ggcuggagug gaugcugcaa gcgucucuga agaauuuagg     1080

gcugaccauc cauuccucuu cuguaucaag cacaucgcaa ccaacgccgu ucucuucuuu     1140

ggcagaugug uuuccccuua a                                               1161


<210>  7
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-M10 Codon optimized ORF

<400>  7
atgggcagca ttggagccgc tagcatggaa ttttgttttg acgtgttcaa ggaactgaag       60

gtccaccacg ccaacgagaa catcttctac tgccccattg ccattatgag cgccctggcc      120

atggtgtacc tgggcgccaa ggattctaca agaacacaga tcaacaaggt ggtgcggttc      180

gacaagctgc ctggcttcgg cgacagcatc gaggcccagt gcggcacatc tgtcaacgtg      240

cacagcagcc tgcgggacat cctgaaccag atcaccaagc ccaacgacgt gtatagcttc      300

agcctggcta gcagactgta cgccgaggag agatacccta tcctgcctga gtacctgcaa      360

tgtgtgaagg aactgtacag aggcggactc gagcctatca atttccagac agccgctgat      420

caggccagag aactgatcaa cagctgggtg gaatctcaaa ccaacggcat catcagaaac      480

gtgctgcagc ctagctctgt ggacagccag accgccatgg tcctggtgaa cgccatcgtg      540

ttcaaaggac tgtgggagaa gaccttcaag gacgaagata cccaggccat gcctttcagg      600

gtgaccgagc aggagagcaa gcctgtgcag atgatgtacc agatcggcct gttccgggtg      660

gccagcatgg cttccgagaa gatgaagatc ctggaactgc cattcgcctc cggcaccatg      720

tctatgctgg ttctgctgcc cgacgaggtg tctggccttg agcagctgga aagcatcatc      780

aacttcgaga aactgaccga gtggaccagc agcaacgtga tggaagagag aaagatcaag      840

gtgtacctgc caagaatgaa aatggaagag aagtacaacc tcacaagcgt gctgatggcc      900

atgggaatca ctgatgtgtt tagcagcagc gcaaatctga gcggcatctc ctccgccgag      960

tctctgaaaa tcagccaagc tgtgcatgct gcccacgccg agatcaatga ggctggcaga     1020

gaggtggtgg gcagcgccga agccggcgtg gacgccgcct ccgtcagcga ggaattccgg     1080

gccgatcacc cctttctgtt ctgcatcaag cacatcgcca ccaatgccgt gctgttcttc     1140

ggccggtgcg tgtccccttg a                                               1161


<210>  8
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-M6-HA

<400>  8
atgaaggcga acctgctggt cctgctgagc gcgctggcgg cggcggacgc ggacacgatc       60

tgcatcggct accacgcgaa caacagcacc gacacggtcg acacggtcct cgagaagaac      120

gtgaccgtga cccacagcgt caacctgctc gaggacagcc acaacgggaa gctgtgcagg      180

ctcaagggca tcgccccgct gcagctgggg aagtgcaaca tcgccggctg gctcttgggg      240

aaccccgagt gcgacccgct gctcccggtg aggagctggt cctacatcgt ggagaccccg      300

aactcggaga acgggatctg ctacccgggg gacttcatcg actacgagga gctgagggag      360

cagttgagct cggtgtcgtc cttcgagagg ttcgagatct tccccaagga gagctcgtgg      420

cccaaccaca acaccaacgg ggtcacggcc gcgtgctccc acgaggggaa gagcagcttc      480

tacaggaact tgctgtggct gacggagaag gagggctcgt acccgaagct gaagaactcg      540

tacgtgaaca agaaggggaa ggaggtcctc gtactgtggg gcatccacca cccgccgaac      600

agcaaggagc agcagaacct ctaccagaac gagaatgcgt acgtctccgt ggtgacctcg      660

aactacaaca ggaggttcac cccggagatc gcggagaggc ccaaggtcag ggaccaggcc      720

gggaggatga actactactg gaccttgctg aagcccggcg acaccatcat cttcgaggcg      780

aacgggaacc tgatcgcacc gatgtatgcg ttcgcgctga gcaggggctt cgggtccggc      840

atcatcacct cgaatgcgtc catgcacgag tgcaacacga agtgccagac gcccctgggc      900

gcgatcaaca gcagcctccc gtaccagaac atccacccgg tcacgatcgg ggagtgcccc      960

aagtacgtca ggagcgccaa gttgaggatg gtgaccgggc tcaggaacac gccgtccatc     1020

cagtccaggg gcctgttcgg ggccatcgcc gggttcatcg aggggggctg gaccggcatg     1080

atcgacgggt ggtacgggta ccaccaccag aacgagcagg ggtcgggcta cgcggcggac     1140

cagaagagca cgcagaacgc catcaacggg atcacgaaca aggtgaacac ggtcatcgag     1200

aagatgaaca tccagttcac ggccgtgggg aaggagttca acaagttgga gaagaggatg     1260

gagaacttga acaagaaggt cgacgacggg ttcctggaca tctggacgta caacgcggag     1320

ttgttggtgc tgctggagaa cgagaggacg ctggacttcc acgactcgaa cgtgaagaac     1380

ctgtacgaga aggtgaagag ccagttgaag aacaacgcca aggagatcgg caacgggtgc     1440

ttcgagttct accacaagtg cgacaacgag tgcatggaga gcgtgaggaa cgggacgtac     1500

gactacccca agtactccga agagtcgaag ttgaacaggg agaaggtgga cggggtgaag     1560

ttggagtcga tggggatcta ccagatcctg gcgatctact cgacggtcgc cagctccctg     1620

gtgctgttgg tctccctggg ggcgatcagc ttctggatgt gctccaacgg gtcgttgcag     1680

tgcaggatct gcatctga                                                   1698


