                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  Hypersialylating cells

<130>  PAT059101-WO-PCT

<150>  US 63/181,746
<151>  2021-04-29

<150>  US 63/181,739
<151>  2021-04-29

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  402
<212>  PRT
<213>  Cricetulus griseus

<400>  1

Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Tyr Phe Ile Leu Ala 
1               5                   10                  15      


Phe Leu Leu Phe Ala Leu Ile Cys Val Trp Lys Lys Gly Ser Tyr Glu 
            20                  25                  30          


Ala Leu Lys Leu Gln Ala Lys Glu Phe Gln Val Thr Arg Ser Leu Glu 
        35                  40                  45              


Lys Leu Ala Met Arg Ser Gly Ser Gln Ser Met Ser Ser Ser Ser Lys 
    50                  55                  60                  


Gln Asp Pro Lys Gln Asp Ser Gln Val Leu Ser His Ala Arg Val Thr 
65                  70                  75                  80  


Ala Lys Val Lys Pro Gln Pro Ser Tyr Gln Val Trp Asp Lys Asn Ser 
                85                  90                  95      


Ser Ser Lys Asn Leu Asn Pro Arg Leu Gln Lys Ile Leu Lys Asn Tyr 
            100                 105                 110         


Leu Asn Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly Pro Gly Pro Gly 
        115                 120                 125             


Val Lys Phe Ser Ala Glu Ala Leu Arg Cys Arg Leu Arg Asp Arg Val 
    130                 135                 140                 


Asn Val Ser Met Ile Glu Ala Thr Asp Phe Pro Phe Asn Thr Thr Glu 
145                 150                 155                 160 


Trp Ala Gly Tyr Leu Pro Lys Glu Asn Ile Arg Thr Lys Ala Gly Pro 
                165                 170                 175     


Trp His Arg Cys Ala Val Val Ser Ser Ala Gly Ser Leu Lys Ser Ser 
            180                 185                 190         


Gln Leu Gly Arg Glu Ile Asp Asn His Asp Ala Val Leu Arg Phe Asn 
        195                 200                 205             


Gly Ala Pro Val Ala Asn Phe Gln Gln Asp Val Gly Thr Lys Thr Thr 
    210                 215                 220                 


Ile Arg Leu Met Asn Ser Gln Leu Ile Thr Thr Glu Lys Gln Phe Leu 
225                 230                 235                 240 


Lys Asp Ser Leu Tyr Ser Glu Gly Ile Leu Ile Val Trp Asp Pro Ser 
                245                 250                 255     


Leu Tyr His Ala Asp Ile Pro Ser Trp Tyr Gln Lys Pro Asp Tyr Asn 
            260                 265                 270         


Phe Phe Glu Thr Tyr Lys Ser Tyr Arg Lys Leu Tyr Pro Asp Gln Pro 
        275                 280                 285             


Phe Tyr Ile Leu Arg Pro Gln Met Pro Trp Glu Leu Trp Asp Ile Ile 
    290                 295                 300                 


Gln Glu Ile Ala Pro Asp Arg Ile Gln Pro Asn Pro Pro Ser Ser Gly 
305                 310                 315                 320 


Met Leu Gly Ile Met Ile Met Met Thr Leu Cys Asp Gln Val Asp Ile 
                325                 330                 335     


Tyr Glu Phe Leu Pro Ser Arg Arg Lys Thr Asp Val Cys Tyr Tyr His 
            340                 345                 350         


Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala Tyr His Pro Leu 
        355                 360                 365             


Leu Phe Glu Lys Asn Met Val Lys Gln Leu Asn Glu Gly Thr Asp Glu 
    370                 375                 380                 


Asp Ile Tyr Ile Phe Gly Lys Ala Thr Leu Ser Gly Phe Arg Thr Ile 
385                 390                 395                 400 


His Cys 
        


<210>  2
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val 
1               5                   10                  15      


Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly 
            20                  25                  30          


Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu 
        35                  40                  45              


Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser 
    50                  55                  60                  


Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser 
65                  70                  75                  80  


Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp 
                85                  90                  95      


Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile 
            100                 105                 110         


Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly 
        115                 120                 125             


Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu 
    130                 135                 140                 


Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe 
145                 150                 155                 160 


Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr 
                165                 170                 175     


Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser 
            180                 185                 190         


Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val 
        195                 200                 205             


Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly 
    210                 215                 220                 


Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu 
225                 230                 235                 240 


Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val 
                245                 250                 255     


Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn 
            260                 265                 270         


Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His 
        275                 280                 285             


Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu 
    290                 295                 300                 


Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro 
305                 310                 315                 320 


Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp 
                325                 330                 335     


Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val 
            340                 345                 350         


Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala 
        355                 360                 365             


Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln 
    370                 375                 380                 


Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly 
385                 390                 395                 400 


Phe Arg Thr Ile His Cys 
                405     


<210>  3
<211>  393
<212>  PRT
<213>  Cricetulus griseus

<400>  3

Met Arg Phe Leu Arg Pro Val Leu Gly Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Thr Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ser Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Ser Thr Leu Arg Ser Gly Thr 
    50                  55                  60                  


Ile Gly Ala Thr Ala Asn Lys Gln Pro Pro Gly Ala Arg Pro Pro Pro 
65                  70                  75                  80  


Pro Val Gly Val Ser Ser Lys Pro Arg Pro Gly Pro Asp Ser Ser Pro 
                85                  90                  95      


Gly Thr Ala Phe Asp Pro Gly Leu Lys Ser Asn Trp Thr Ser Val Leu 
            100                 105                 110         


Val Pro Pro Thr Thr Ala Leu Leu Thr Leu Pro Ala Cys Pro Glu Glu 
        115                 120                 125             


Ser Pro Leu Leu Val Gly Pro Met Val Ile Asp Phe Asn Ile Ala Val 
    130                 135                 140                 


Asp Leu Glu Leu Leu Ala Lys Lys Asn Pro Glu Ile Lys Met Gly Gly 
145                 150                 155                 160 


Arg Tyr Ser Pro Lys Asp Cys Ile Ser Pro His Lys Val Ala Ile Ile 
                165                 170                 175     


Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys Tyr Trp Leu Tyr Tyr 
            180                 185                 190         


Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val 
        195                 200                 205             


Ile Asn Gln Ala Gly Asp Thr Met Phe Asn Arg Ala Lys Leu Leu Asn 
    210                 215                 220                 


Ile Gly Phe Gln Glu Ala Leu Lys Asp His Asp Tyr Asn Cys Phe Val 
225                 230                 235                 240 


Phe Ser Asp Val Asp Leu Ile Pro Met Asp Asp His Asn Ala Tyr Arg 
                245                 250                 255     


Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala Met Asp Lys Phe Gly 
            260                 265                 270         


Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly Val Ser Ala Leu Ser 
        275                 280                 285             


Lys Gln Gln Phe Leu Ala Ile Asn Gly Phe Pro Asn Asn Tyr Trp Gly 
    290                 295                 300                 


Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg Ile Val His Lys Gly 
305                 310                 315                 320 


Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly Arg Cys Arg Met Ile 
                325                 330                 335     


Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn Pro Gln Arg Phe Asp 
            340                 345                 350         


Arg Ile Ala His Thr Lys Glu Thr Met Arg Phe Asp Gly Leu Asn Ser 
        355                 360                 365             


Leu Thr Tyr Gln Val Leu Asn Val Glu Arg Tyr Pro Leu Tyr Thr Lys 
    370                 375                 380                 


Ile Thr Val Asp Ile Gly Thr Pro Arg 
385                 390             


<210>  4
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Leu Arg Glu Pro Leu Leu Ser Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Ser 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val Ser Thr Pro Leu Gln Gly Gly Ser 
    50                  55                  60                  


Asn Ser Ala Ala Ala Ile Gly Gln Ser Ser Gly Glu Leu Arg Thr Gly 
65                  70                  75                  80  


Gly Ala Arg Pro Pro Pro Pro Leu Gly Ala Ser Ser Gln Pro Arg Pro 
                85                  90                  95      


Gly Gly Asp Ser Ser Pro Val Val Asp Ser Gly Pro Gly Pro Ala Ser 
            100                 105                 110         


Asn Leu Thr Ser Val Pro Val Pro His Thr Thr Ala Leu Ser Leu Pro 
        115                 120                 125             


Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro Met Leu Ile Glu 
    130                 135                 140                 


Phe Asn Met Pro Val Asp Leu Glu Leu Val Ala Lys Gln Asn Pro Asn 
145                 150                 155                 160 


Val Lys Met Gly Gly Arg Tyr Ala Pro Arg Asp Cys Val Ser Pro His 
                165                 170                 175     


Lys Val Ala Ile Ile Ile Pro Phe Arg Asn Arg Gln Glu His Leu Lys 
            180                 185                 190         


Tyr Trp Leu Tyr Tyr Leu His Pro Val Leu Gln Arg Gln Gln Leu Asp 
        195                 200                 205             


Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Asp Thr Ile Phe Asn Arg 
    210                 215                 220                 


Ala Lys Leu Leu Asn Val Gly Phe Gln Glu Ala Leu Lys Asp Tyr Asp 
225                 230                 235                 240 


Tyr Thr Cys Phe Val Phe Ser Asp Val Asp Leu Ile Pro Met Asn Asp 
                245                 250                 255     


His Asn Ala Tyr Arg Cys Phe Ser Gln Pro Arg His Ile Ser Val Ala 
            260                 265                 270         


Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln Tyr Phe Gly Gly 
        275                 280                 285             


Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Thr Ile Asn Gly Phe Pro 
    290                 295                 300                 


Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Ile Phe Asn Arg 
305                 310                 315                 320 


Leu Val Phe Arg Gly Met Ser Ile Ser Arg Pro Asn Ala Val Val Gly 
                325                 330                 335     


Arg Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys Asn Glu Pro Asn 
            340                 345                 350         


Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu Thr Met Leu Ser 
        355                 360                 365             


Asp Gly Leu Asn Ser Leu Thr Tyr Gln Val Leu Asp Val Gln Arg Tyr 
    370                 375                 380                 


Pro Leu Tyr Thr Gln Ile Thr Val Asp Ile Gly Thr Pro Ser 
385                 390                 395             


<210>  5
<211>  336
<212>  PRT
<213>  Cricetulus griseus

<400>  5

Met Ala Gln Ala Arg Glu Asn Val Ser Leu Phe Phe Lys Leu Tyr Cys 
1               5                   10                  15      


Leu Ala Val Met Thr Leu Val Ala Ala Ala Tyr Thr Val Ala Leu Arg 
            20                  25                  30          


Tyr Thr Arg Thr Thr Ala Lys Glu Leu Tyr Phe Ser Thr Thr Ala Val 
        35                  40                  45              


Cys Val Thr Glu Val Ile Lys Leu Leu Ile Ser Val Gly Leu Leu Ala 
    50                  55                  60                  


Lys Glu Thr Gly Ser Leu Gly Arg Phe Lys Ala Ser Leu Ser Glu Asn 
65                  70                  75                  80  


Val Leu Gly Ser Pro Lys Glu Leu Met Lys Leu Ser Val Pro Ser Leu 
                85                  90                  95      


Val Tyr Ala Val Gln Asn Asn Met Ala Phe Leu Ala Leu Ser Asn Leu 
            100                 105                 110         


Asp Ala Ala Val Tyr Gln Val Thr Tyr Gln Leu Lys Ile Pro Cys Thr 
        115                 120                 125             


Ala Leu Cys Thr Val Leu Met Leu Asn Arg Thr Leu Ser Lys Leu Gln 
    130                 135                 140                 


Trp Val Ser Val Phe Met Leu Cys Gly Gly Val Ile Leu Val Gln Trp 
145                 150                 155                 160 


Lys Pro Ala Gln Ala Thr Lys Val Val Val Glu Gln Ser Pro Leu Leu 
                165                 170                 175     


Gly Phe Gly Ala Ile Ala Ile Ala Val Leu Cys Ser Gly Phe Ala Gly 
            180                 185                 190         


Val Tyr Phe Glu Lys Val Leu Lys Ser Ser Asp Thr Ser Leu Trp Val 
        195                 200                 205             


Arg Asn Ile Gln Met Tyr Leu Ser Gly Ile Val Val Thr Leu Val Gly 
    210                 215                 220                 


Thr Tyr Leu Ser Asp Gly Ala Glu Ile Lys Glu Lys Gly Phe Phe Tyr 
225                 230                 235                 240 


Gly Tyr Thr Tyr Tyr Val Trp Phe Val Ile Phe Leu Ala Ser Val Gly 
                245                 250                 255     


Gly Leu Tyr Thr Ser Val Val Val Lys Tyr Thr Asp Asn Ile Met Lys 
            260                 265                 270         


Gly Phe Ser Ala Ala Ala Ala Ile Val Leu Ser Thr Ile Ala Ser Val 
        275                 280                 285             


Met Leu Phe Gly Leu Gln Ile Thr Leu Ser Phe Ala Met Gly Ala Leu 
    290                 295                 300                 


Leu Val Cys Ile Ser Ile Tyr Leu Tyr Gly Leu Pro Arg Gln Asp Thr 
305                 310                 315                 320 


Thr Cys Ile Gln Gln Glu Ala Thr Ser Lys Glu Arg Val Ile Gly Val 
                325                 330                 335     


<210>  6
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Pro Arg Asp Asn Val Thr Leu Leu Phe Lys Leu Tyr Cys 
1               5                   10                  15      


Leu Ala Val Met Thr Leu Met Ala Ala Val Tyr Thr Ile Ala Leu Arg 
            20                  25                  30          


Tyr Thr Arg Thr Ser Asp Lys Glu Leu Tyr Phe Ser Thr Thr Ala Val 
        35                  40                  45              


Cys Ile Thr Glu Val Ile Lys Leu Leu Leu Ser Val Gly Ile Leu Ala 
    50                  55                  60                  


Lys Glu Thr Gly Ser Leu Gly Arg Phe Lys Ala Ser Leu Arg Glu Asn 
65                  70                  75                  80  


Val Leu Gly Ser Pro Lys Glu Leu Leu Lys Leu Ser Val Pro Ser Leu 
                85                  90                  95      


Val Tyr Ala Val Gln Asn Asn Met Ala Phe Leu Ala Leu Ser Asn Leu 
            100                 105                 110         


Asp Ala Ala Val Tyr Gln Val Thr Tyr Gln Leu Lys Ile Pro Cys Thr 
        115                 120                 125             


Ala Leu Cys Thr Val Leu Met Leu Asn Arg Thr Leu Ser Lys Leu Gln 
    130                 135                 140                 


Trp Val Ser Val Phe Met Leu Cys Ala Gly Val Thr Leu Val Gln Trp 
145                 150                 155                 160 


Lys Pro Ala Gln Ala Thr Lys Val Val Val Glu Gln Asn Pro Leu Leu 
                165                 170                 175     


Gly Phe Gly Ala Ile Ala Ile Ala Val Leu Cys Ser Gly Phe Ala Gly 
            180                 185                 190         


Val Tyr Phe Glu Lys Val Leu Lys Ser Ser Asp Thr Ser Leu Trp Val 
        195                 200                 205             


Arg Asn Ile Gln Met Tyr Leu Ser Gly Ile Ile Val Thr Leu Ala Gly 
    210                 215                 220                 


Val Tyr Leu Ser Asp Gly Ala Glu Ile Lys Glu Lys Gly Phe Phe Tyr 
225                 230                 235                 240 


Gly Tyr Thr Tyr Tyr Val Trp Phe Val Ile Phe Leu Ala Ser Val Gly 
                245                 250                 255     


Gly Leu Tyr Thr Ser Val Val Val Lys Tyr Thr Asp Asn Ile Met Lys 
            260                 265                 270         


Gly Phe Ser Ala Ala Ala Ala Ile Val Leu Ser Thr Ile Ala Ser Val 
        275                 280                 285             


Met Leu Phe Gly Leu Gln Ile Thr Leu Thr Phe Ala Leu Gly Thr Leu 
    290                 295                 300                 


Leu Val Cys Val Ser Ile Tyr Leu Tyr Gly Leu Pro Arg Gln Asp Thr 
305                 310                 315                 320 


Thr Ser Ile Gln Gln Gly Glu Thr Ala Ser Lys Glu Arg Val Ile Gly 
                325                 330                 335     


Val 
    


