                         SEQUENCE LISTING

<110>  CRISPR THERAPEUTICS AG
       BOLUKBASI, Fatih
       ANDERSON, Eric G.
 
<120>  COMPOSITIONS AND METHODS FOR USING SLUCAS9 SCAFFOLD SEQUENCES

<130>  100867-725788 (CT164-P1)

<150>  US 63/179,853
<151>  2021-04-26

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  1053
<212>  PRT
<213>  Staphylococcus lugdunensis

<400>  1

Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu Glu 
    50                  55                  60                  


Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser Gln 
65                  70                  75                  80  


Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp Asp 
        115                 120                 125             


Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser Lys 
    130                 135                 140                 


Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met Asn 
145                 150                 155                 160 


Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp Ile 
                165                 170                 175     


Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His Gln 
            180                 185                 190         


Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met Arg 
        195                 200                 205             


Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp Glu 
    210                 215                 220                 


Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu 
                245                 250                 255     


Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp Gly 
            260                 265                 270         


Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu Ile 
    290                 295                 300                 


Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly 
305                 310                 315                 320 


Lys Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Val 
                325                 330                 335     


Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln Ile 
            340                 345                 350         


Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser Lys 
        355                 360                 365             


Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn Ile 
    370                 375                 380                 


Ala Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys Cys 
385                 390                 395                 400 


Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln Met 
                405                 410                 415     


Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu Thr 
            420                 425                 430         


Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn Lys 
    450                 455                 460                 


Ile Ile Glu Lys Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Asn Asn Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met Gln 
                485                 490                 495     


Lys Lys Asn Glu Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Lys 
            500                 505                 510         


Tyr Gly Asn Gln Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu His 
        515                 520                 525             


Asp Glu Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro Leu 
    530                 535                 540                 


Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln Tyr 
            580                 585                 590         


Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln His 
        595                 600                 605             


Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln Lys 
625                 630                 635                 640 


Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Glu 
                645                 650                 655     


Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn Val 
            660                 665                 670         


Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys Val 
        675                 680                 685             


Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys 
705                 710                 715                 720 


Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu Thr 
                725                 730                 735     


Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu Met 
            740                 745                 750         


Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn Phe 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile Val 
785                 790                 795                 800 


Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys Lys 
                805                 810                 815     


Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp Pro 
            820                 825                 830         


Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn Glu 
        835                 840                 845             


Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu Thr 
    850                 855                 860                 


Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys Tyr 
865                 870                 875                 880 


Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe Lys 
                885                 890                 895     


Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg Phe 
            900                 905                 910         


Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser Tyr 
        915                 920                 925             


Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln Lys 
    930                 935                 940                 


Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys Phe 
945                 950                 955                 960 


Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu Ile 
                965                 970                 975     


Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu Leu 
            980                 985                 990         


Asp Leu Pro Asp Ile Arg Tyr Lys  Glu Tyr Cys Glu Leu  Asn Asn Ile 
        995                 1000                 1005             


Lys Gly  Glu Pro Arg Ile Lys  Lys Thr Ile Gly Lys  Lys Val Asn 
    1010                 1015                 1020             


Ser Ile  Glu Lys Leu Thr Thr  Asp Val Leu Gly Asn  Val Phe Thr 
    1025                 1030                 1035             


Asn Thr  Gln Tyr Thr Lys Pro  Gln Leu Leu Phe Lys  Arg Gly Asn 
    1040                 1045                 1050             


<210>  2
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
gttttagtac tctggaaaca gaatctactg aaacaagaca atatgtcgtg tttatcccat       60

caatttattg gtggga                                                       76


<210>  3
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
gtttaagtac tctgtgctgg aaacagcaca gaatctactg aaacaagaca atatgtcgtg       60

tttatcccat caatttattg gtggga                                            86


<210>  4
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
gtttcagtac tctgtgctgg aaacagcaca gaatctactg aaacaagaca atatgtcgtg       60

tttatcccat caatttattg gtgggat                                           87


<210>  5
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
gtttcagtac tctggaaaca gaatctactg aaacaagaca atatgtcgtg tttatcccat       60

caatttattg gtgggat                                                      77


<210>  6
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
gtttggtaac ctaggaaact agatcttacc aaacaagaca atatgtcgtg tttatcccat       60

caatttattg gtgggat                                                      77


<210>  7
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gtttcagtac tctggaaaca gaatctactg aaacaaggca aaatgccgtg tttatcccat       60

caatttattg gtgggat                                                      77


<210>  8
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
gtttcagtac tctggaaaca gaatctactg aaacaagaca atatgtcgcg cccatcccat       60

caatttattg gtgggat                                                      77


<210>  9
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
gtttcagtac tctggaaaca gaatctactg aaacaagaca atatgtcgtg tttatgggtt       60

gaatttattc gacccat                                                      77


<210>  10
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
gtttggtaac ctaggaaact agatcttacc aaacaaggca aaatgccgtg tttatcccat       60

caatttattg gtgggat                                                      77


<210>  11
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
gtttggtaac ctaggaaact agatcttacc aaacaagaca atatgtcgcg cccatcccat       60

caatttattg gtgggat                                                      77


<210>  12
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
gtttggtaac ctaggaaact agatcttacc aaacaagaca atatgtcgtg tttatgggtt       60

gaatttattc gacccat                                                      77


<210>  13
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
gtttcagtac tctggaaaca gaatctactg aaacaaggca aaatgccgcg cccatcccat       60

caatttattg gtgggat                                                      77


<210>  14
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
gtttcagtac tctggaaaca gaatctactg aaacaaggca aaatgccgtg tttatgggtt       60

gaatttattc gacccat                                                      77


<210>  15
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
gtttcagtac tctggaaaca gaatctactg aaacaagaca atatgtcgcg cccatgggtt       60

gaatttattc gacccat                                                      77


<210>  16
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gtttggtaac ctaggaaact agatcttacc aaacaaggca aaatgccgcg cccatcccat       60

caatttattg gtgggat                                                      77


<210>  17
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
gtttggtaac ctaggaaact agatcttacc aaacaaggca aaatgccgtg tttatgggtt       60

gaatttattc gacccat                                                      77


<210>  18
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
gtttggtaac ctaggaaact agatcttacc aaacaagaca atatgtcgcg cccatgggtt       60

gaatttattc gacccat                                                      77


<210>  19
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
gtttcagtac tctggaaaca gaatctactg aaacaaggca aaatgccgcg cccatgggtt       60

gaatttattc gacccat                                                      77


<210>  20
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
gtttggtaac ctaggaaact agatcttacc aaacaaggca aaatgccgcg cccatgggtt       60

gaatttattc gacccat                                                      77


<210>  21
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
ctagactagc atgctgccca tgtaaggagg caaggcctgg ggacacccga gatgcctggt       60

tataattaac ccagacatgt ggctgccccc ccccccccaa cacctgctgc ctctaaaaat      120

aaccctgcat gccatgttcc cggcgaaggg ccagctgtcc cccgccagct agactcagca      180

cttagtttag gaaccagtga gcaagtcagc ccttggggca gcccatacaa ggccatgggg      240

ctgggcaagc tgcacgcctg ggtccggggt gggcacggtg cccgggcaac gagctgaaag      300

ctcatctgct ctcaggggcc cctccctggg gacagcccct cctggctagt cacaccctgt      360

aggctcctct atataaccca ggggcacagg ggctgccctc attctaccac cacctccaca      420

gcacagacag acactcagga gccagccagc                                       450


<210>  22
<211>  436
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
tgcccatgta aggaggcaag gcctggggac acccgagatg cctggttata attaacccag       60

acatgtggct gccccccccc ccccaacacc tgctgcctct aaaaataacc ctgcatgcca      120

tgttcccggc gaagggccag ctgtcccccg ccagctagac tcagcactta gtttaggaac      180

cagtgagcaa gtcagccctt ggggcagccc atacaaggcc atggggctgg gcaagctgca      240

cgcctgggtc cggggtgggc acggtgcccg ggcaacgagc tgaaagctca tctgctctca      300

ggggcccctc cctggggaca gcccctcctg gctagtcaca ccctgtaggc tcctctatat      360

aacccagggg cacaggggct gccctcattc taccaccacc tccacagcac agacagacac      420

tcaggagcca gccagc                                                      436


<210>  23
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu Glu 
    50                  55                  60                  


Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser Gln 
65                  70                  75                  80  


Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp Asp 
        115                 120                 125             


Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser Lys 
    130                 135                 140                 


Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met Asn 
145                 150                 155                 160 


Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp Ile 
                165                 170                 175     


Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His Gln 
            180                 185                 190         


Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met Arg 
        195                 200                 205             


Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp Glu 
    210                 215                 220                 


Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu 
                245                 250                 255     


Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp Gly 
            260                 265                 270         


Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu Ile 
    290                 295                 300                 


Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly 
305                 310                 315                 320 


Lys Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Val 
                325                 330                 335     


Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln Ile 
            340                 345                 350         


Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser Lys 
        355                 360                 365             


Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn Ile 
    370                 375                 380                 


Ala Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys Cys 
385                 390                 395                 400 


Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Asn Gln Met 
                405                 410                 415     


Glu Ile Phe Thr His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu Thr 
            420                 425                 430         


Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn Lys 
    450                 455                 460                 


Ile Ile Glu Lys Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Asn Asn Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met Gln 
                485                 490                 495     


Lys Lys Asn Glu Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Lys 
            500                 505                 510         


Tyr Gly Asn Gln Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu His 
        515                 520                 525             


Asp Glu Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro Leu 
    530                 535                 540                 


Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln Tyr 
            580                 585                 590         


Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln His 
        595                 600                 605             


Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln Lys 
625                 630                 635                 640 


Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Glu 
                645                 650                 655     


Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn Val 
            660                 665                 670         


Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys Val 
        675                 680                 685             


Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys 
705                 710                 715                 720 


Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu Thr 
                725                 730                 735     


Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu Met 
            740                 745                 750         


Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn Phe 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile Val 
785                 790                 795                 800 


Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys Lys 
                805                 810                 815     


Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp Pro 
            820                 825                 830         


Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn Glu 
        835                 840                 845             


Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu Thr 
    850                 855                 860                 


Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys Tyr 
865                 870                 875                 880 


Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe Lys 
                885                 890                 895     


Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg Phe 
            900                 905                 910         


Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser Tyr 
        915                 920                 925             


Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln Lys 
    930                 935                 940                 


Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys Phe 
945                 950                 955                 960 


Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu Ile 
                965                 970                 975     


Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu Leu 
            980                 985                 990         


Asp Leu Pro Asp Ile Arg Tyr Lys  Glu Tyr Cys Glu Leu  Asn Asn Ile 
        995                 1000                 1005             


Lys Gly  Glu Pro His Ile Lys  Lys Thr Ile Gly Lys  Lys Val Asn 
    1010                 1015                 1020             


Ser Ile  Glu Lys Leu Thr Thr  Asp Val Leu Gly Asn  Val Phe Thr 
    1025                 1030                 1035             


Asn Thr  Gln Tyr Thr Lys Pro  Gln Leu Leu Phe Lys  Arg Gly Asn 
    1040                 1045                 1050             


<210>  24
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu Glu 
    50                  55                  60                  


Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser Gln 
65                  70                  75                  80  


Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp Asp 
        115                 120                 125             


Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser Lys 
    130                 135                 140                 


Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met Asn 
145                 150                 155                 160 


Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp Ile 
                165                 170                 175     


Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His Gln 
            180                 185                 190         


Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met Arg 
        195                 200                 205             


Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp Glu 
    210                 215                 220                 


Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Asp Glu Leu Ala Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu 
                245                 250                 255     


Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp Gly 
            260                 265                 270         


Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu Ile 
    290                 295                 300                 


Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly 
305                 310                 315                 320 


Lys Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Val 
                325                 330                 335     


Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln Ile 
            340                 345                 350         


Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser Lys 
        355                 360                 365             


Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn Ile 
    370                 375                 380                 


Ala Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys Cys 
385                 390                 395                 400 


Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Ala Gln Met 
                405                 410                 415     


Glu Ile Phe Ala His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu Thr 
            420                 425                 430         


Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn Lys 
    450                 455                 460                 


Ile Ile Glu Lys Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Asn Asn Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met Gln 
                485                 490                 495     


Lys Lys Asn Glu Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Lys 
            500                 505                 510         


Tyr Gly Asn Gln Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu His 
        515                 520                 525             


Asp Glu Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro Leu 
    530                 535                 540                 


Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln Tyr 
            580                 585                 590         


Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln His 
        595                 600                 605             


Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln Lys 
625                 630                 635                 640 


Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Ala Glu 
                645                 650                 655     


Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn Val 
            660                 665                 670         


Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys Val 
        675                 680                 685             


Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys 
705                 710                 715                 720 


Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu Thr 
                725                 730                 735     


Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu Met 
            740                 745                 750         


Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn Phe 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gln Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile Val 
785                 790                 795                 800 


Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys Lys 
                805                 810                 815     


Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp Pro 
            820                 825                 830         


Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn Glu 
        835                 840                 845             


Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu Thr 
    850                 855                 860                 


Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys Tyr 
865                 870                 875                 880 


Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe Lys 
                885                 890                 895     


Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg Phe 
            900                 905                 910         


Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser Tyr 
        915                 920                 925             


Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln Lys 
    930                 935                 940                 


Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys Phe 
945                 950                 955                 960 


Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu Ile 
                965                 970                 975     


Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu Leu 
            980                 985                 990         


Asp Leu Pro Asp Ile Arg Tyr Lys  Glu Tyr Cys Glu Leu  Asn Asn Ile 
        995                 1000                 1005             


Lys Gly  Glu Pro Arg Ile Lys  Lys Thr Ile Gly Lys  Lys Val Asn 
    1010                 1015                 1020             


Ser Ile  Glu Lys Leu Thr Thr  Asp Val Leu Gly Asn  Val Phe Thr 
    1025                 1030                 1035             


Asn Thr  Gln Tyr Thr Lys Pro  Gln Leu Leu Phe Lys  Arg Gly Asn 
    1040                 1045                 1050             


<210>  25
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Asn Gln Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu Glu 
    50                  55                  60                  


Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gln Ser Gln 
65                  70                  75                  80  


Ile Pro Gln Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile Ala 
            100                 105                 110         


Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp Asp 
        115                 120                 125             


Val Gly Asn Glu Leu Ser Thr Lys Glu Gln Leu Asn Lys Asn Ser Lys 
    130                 135                 140                 


Leu Leu Lys Asp Lys Phe Val Cys Gln Ile Gln Leu Glu Arg Met Asn 
145                 150                 155                 160 


Glu Gly Gln Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp Ile 
                165                 170                 175     


Ile Lys Glu Ile Ile Gln Leu Leu Asn Val Gln Lys Asn Phe His Gln 
            180                 185                 190         


Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met Arg 
        195                 200                 205             


Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp Glu 
    210                 215                 220                 


Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr Tyr 
225                 230                 235                 240 


Phe Pro Asp Glu Leu Ala Ser Val Lys Tyr Ala Tyr Ser Ala Asp Leu 
                245                 250                 255     


Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gln Arg Asp Gly 
            260                 265                 270         


Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn Val 
        275                 280                 285             


Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Asn Glu Ile 
    290                 295                 300                 


Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Gly 
305                 310                 315                 320 


Lys Pro Gln Phe Thr Glu Phe Lys Leu Tyr His Asp Leu Lys Ser Val 
                325                 330                 335     


Leu Phe Asp Gln Ser Ile Leu Glu Asn Glu Asp Val Leu Asp Gln Ile 
            340                 345                 350         


Ala Glu Ile Leu Thr Ile Tyr Gln Asp Lys Asp Ser Ile Lys Ser Lys 
        355                 360                 365             


Leu Thr Glu Leu Asp Ile Leu Leu Asn Glu Glu Asp Lys Glu Asn Ile 
    370                 375                 380                 


Ala Gln Leu Thr Gly Tyr Thr Gly Thr His Arg Leu Ser Leu Lys Cys 
385                 390                 395                 400 


Ile Arg Leu Val Leu Glu Glu Gln Trp Tyr Ser Ser Arg Ala Gln Met 
                405                 410                 415     


Glu Ile Phe Ala His Leu Asn Ile Lys Pro Lys Lys Ile Asn Leu Thr 
            420                 425                 430         


Ala Ala Asn Lys Ile Pro Lys Ala Met Ile Asp Glu Phe Ile Leu Ser 
        435                 440                 445             


Pro Val Val Lys Arg Thr Phe Gly Gln Ala Ile Asn Leu Ile Asn Lys 
    450                 455                 460                 


Ile Ile Glu Lys Tyr Gly Val Pro Glu Asp Ile Ile Ile Glu Leu Ala 
465                 470                 475                 480 


Arg Glu Asn Asn Ser Lys Asp Lys Gln Lys Phe Ile Asn Glu Met Gln 
                485                 490                 495     


Lys Lys Asn Glu Asn Thr Arg Lys Arg Ile Asn Glu Ile Ile Gly Lys 
            500                 505                 510         


Tyr Gly Asn Gln Asn Ala Lys Arg Leu Val Glu Lys Ile Arg Leu His 
        515                 520                 525             


Asp Glu Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ser Ile Pro Leu 
    530                 535                 540                 


Glu Asp Leu Leu Asn Asn Pro Asn His Tyr Glu Val Asp His Ile Ile 
545                 550                 555                 560 


Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu Val 
                565                 570                 575     


Lys Gln Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gln Tyr 
            580                 585                 590         


Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gln Phe Lys Gln His 
        595                 600                 605             


Ile Leu Asn Leu Ser Lys Ser Gln Asp Arg Ile Ser Lys Lys Lys Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gln Lys 
625                 630                 635                 640 


Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Ala Glu 
                645                 650                 655     


Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn Val 
            660                 665                 670         


Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys Val 
        675                 680                 685             


Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala Glu 
    690                 695                 700                 


Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn Lys 
705                 710                 715                 720 


Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu Thr 
                725                 730                 735     


Lys Gln Leu Asp Ile Gln Val Asp Ser Glu Asp Asn Tyr Ser Glu Met 
            740                 745                 750         


Phe Ile Ile Pro Lys Gln Val Gln Asp Ile Lys Asp Phe Arg Asn Phe 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Lys Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile Val 
785                 790                 795                 800 


Gln Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys Lys 
                805                 810                 815     


Gln Phe Asp Lys Ser Pro Glu Lys Phe Leu Met Tyr Gln His Asp Pro 
            820                 825                 830         


Arg Thr Phe Glu Lys Leu Glu Val Ile Met Lys Gln Tyr Ala Asn Glu 
        835                 840                 845             


Lys Asn Pro Leu Ala Lys Tyr His Glu Glu Thr Gly Glu Tyr Leu Thr 
    850                 855                 860                 


Lys Tyr Ser Lys Lys Asn Asn Gly Pro Ile Val Lys Ser Leu Lys Tyr 
865                 870                 875                 880 


Ile Gly Asn Lys Leu Gly Ser His Leu Asp Val Thr His Gln Phe Lys 
                885                 890                 895     


Ser Ser Thr Lys Lys Leu Val Lys Leu Ser Ile Lys Pro Tyr Arg Phe 
            900                 905                 910         


Asp Val Tyr Leu Thr Asp Lys Gly Tyr Lys Phe Ile Thr Ile Ser Tyr 
        915                 920                 925             


Leu Asp Val Leu Lys Lys Asp Asn Tyr Tyr Tyr Ile Pro Glu Gln Lys 
    930                 935                 940                 


Tyr Asp Lys Leu Lys Leu Gly Lys Ala Ile Asp Lys Asn Ala Lys Phe 
945                 950                 955                 960 


Ile Ala Ser Phe Tyr Lys Asn Asp Leu Ile Lys Leu Asp Gly Glu Ile 
                965                 970                 975     


Tyr Lys Ile Ile Gly Val Asn Ser Asp Thr Arg Asn Met Ile Glu Leu 
            980                 985                 990         


Asp Leu Pro Asp Ile Arg Tyr Lys  Glu Tyr Cys Glu Leu  Asn Asn Ile 
        995                 1000                 1005             


Lys Gly  Glu Pro His Ile Lys  Lys Thr Ile Gly Lys  Lys Val Asn 
    1010                 1015                 1020             


Ser Ile  Glu Lys Leu Thr Thr  Asp Val Leu Gly Asn  Val Phe Thr 
    1025                 1030                 1035             


Asn Thr  Gln Tyr Thr Lys Pro  Gln Leu Leu Phe Lys  Arg Gly Asn 
    1040                 1045                 1050             


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  28
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
guuuaaguac ucugugcugg aaacagcaca gaaucuacug aaacaagaca auaugucgug       60

uuuaucccau caauuuauug guggga                                            86


<210>  29
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
guuucaguac ucugugcugg aaacagcaca gaaucuacug aaacaagaca auaugucgug       60

uuuaucccau caauuuauug gugggau                                           87


<210>  30
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
guuucaguac ucuggaaaca gaaucuacug aaacaagaca auaugucgug uuuaucccau       60

caauuuauug gugggau                                                      77


<210>  31
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
tcgtcggcag cgtcagatgt gtataagaga caggtctttc tgtcttgtat cctttgg          57


<210>  32
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
gtctcgtggg ctcggagatg tgtataagag acagaatgtt agtgcctttc accc             54


