﻿               SEQUENCE LISTING

<110> TIRMED PHARMA AB

<120> SINGLE-STRANDED OLIGONUCLEOTIDES FOR USE IN THE MEDICAL TREATMENT AND/OR PROPHYLAXIS OF VIRUS INFECTIONS

<130> 21134670

<160> 27

<170> BiSSAP 1.3.6

<210> 1
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 35 PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 1
gaagttttga ggttttgaag ttgttggtgg tggtg                                35


<210> 2
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 35 PO

<400> 2
gaagttttga ggttttgaag ttgttggtgg tggtg                                35


<210> 3
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 30 PS

<220> 
<221> misc_feature
<222> 1..30
<223> /note="Phosphorothioate linkages"

<400> 3
agttttgagg ttttgaagtt gttggtggtg                                     30


<210> 4
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 25 PS

<220> 
<221> misc_feature
<222> 1..25
<223> /note="Phosphorothioate linkages"

<400> 4
tttgaggttt tgaagttgtt ggtgg                                          25


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 20 PS

<220> 
<221> misc_feature
<222> 1..20
<223> /note="Phosphorothioate linkages"

<400> 5
tgaggttttg aagttattgg                                                20


<210> 6
<211> 15
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 15 PS

<220> 
<221> misc_feature
<222> 1..15
<223> /note="Phosphorothioate linkages"

<400> 6
ggttttgaag ttgtt                                                     15


<210> 7
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 35 PS Complementary

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 7
caccaccacc aacaacttca aaacctcaaa acttc                                35


<210> 8
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 35 2’OMe PS

<220> 
<221> modified_base
<222> 1
<223> /mod_base="gm"

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkage"

<220> 
<221> modified_base
<222> 2..3
<223> /mod_base="OTHER"
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base="gm"

<220> 
<221> modified_base
<222> 5..8
<223> /mod_base="OTHER"
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base="gm"

<220> 
<221> modified_base
<222> 10
<223> /mod_base="OTHER"
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 11..12
<223> /mod_base="gm"

<220> 
<221> modified_base
<222> 13..16
<223> /mod_base="OTHER"
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base="gm"

<220> 
<221> modified_base
<222> 18..19
<223> /mod_base="OTHER"
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 20
<223> /mod_base="gm"

<220> 
<221> modified_base
<222> 21..22
<223> /mod_base="OTHER"
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 23
<223> /mod_base="gm"

<220> 
<221> modified_base
<222> 24..25
<223> /mod_base="OTHER"
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 26..27
<223> /mod_base="gm"

<220> 
<221> modified_base
<222> 28
<223> /mod_base="OTHER"
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 29..30
<223> /mod_base="gm"

<220> 
<221> modified_base
<222> 31
<223> /mod_base="OTHER"
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 32..33
<223> /mod_base="gm"

<220> 
<221> modified_base
<222> 34
<223> /mod_base="OTHER"
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 35
<223> /mod_base="gm"

<400> 8
gaaguuuuga gguuuugaag uuguuggugg uggug                                35


<210> 9
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON A-rich PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 9
aaaataaaat aaaataaaat aaaataaaat aaaat                                35


<210> 10
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON T-rich PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 10
tttttttttt tttttttttt tttttttttt ttttt                                35


<210> 11
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON C-rich PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 11
cccctcccct cccctcccct cccctcccct cccct                                35


<210> 12
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON G-rich PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 12
gggaagggaa gggaagggaa gggaagggaa gggaa                                35


<210> 13
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> G-ssON 35 0% PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 13
cactccactc aatccatcac cacactctct catct                                35


<210> 14
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> G-ssON 35 8% PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 14
gactccactc aatccatcac cacactctgt gatct                                35


<210> 15
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> G-ssON 35 15% PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 15
gactccactg aatccatcac cacagtctgt gatct                                35


<210> 16
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> G-ssON 35 23% PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 16
gagtccactg aatccatgac cacagtctgt gatgt                                35


<210> 17
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> G-ssON 35 29% PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 17
gagtccagtg aatccatgac cagagtctgt gatgt                                35


<210> 18
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> G-ssON 35 37% PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 18
gagtccagtg aatggatgac caaggtgtgt gatgt                                35


<210> 19
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> G-ssON 35 49% PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 19
gagtggagtg aatggatgag gagagtgtgt gatgt                                35


<210> 20
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 35 AT PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 20
aattaattat aatatatata atattaataa taata                                35


<210> 21
<211> 70
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 70 PS

<220> 
<221> misc_feature
<222> 1..70
<223> /note="Phosphorothioate linkages"

<400> 21
gaagttttga ggttttgaag ttgttggtgg tggtggaagt tttgaggttt tgaagttgtt     60

ggtggtggtg                                                            70


<210> 22
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 35 3ePS

<220> 
<221> misc_feature
<222> 1..3
<223> /note="Phosphorothioate linkages"

<220> 
<221> misc_feature
<222> 32..34
<223> /note="Phosphorothioate linkages"

<400> 22
gaagttttga ggttttgaag ttgttggtgg tggtg                                35


<210> 23
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON 35 3eOMe

<220> 
<221> modified_base
<222> 1
<223> /mod_base="gm"

<220> 
<221> misc_feature
<222> 1..3
<223> /note="Phosphorothioate linkages"

<220> 
<221> modified_base
<222> 2..3
<223> /mod_base="OTHER"
      /note="2'-O-methyladenosine"

<220> 
<221> misc_feature
<222> 32..34
<223> /note="Phosphorothioate linkages"

<220> 
<221> modified_base
<222> 33
<223> /mod_base="gm"

<220> 
<221> modified_base
<222> 34
<223> /mod_base="OTHER"
      /note="2'-O-methylthymidine"

<220> 
<221> modified_base
<222> 35
<223> /mod_base="gm"

<400> 23
gaagttttga ggttttgaag ttgttggtgg tggtg                                35


<210> 24
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON GtA PS

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 24
aaaattttaa aattttaaaa ttattaataa taata                                35


<210> 25
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> ssON G29A PSv1

<220> 
<221> misc_feature
<222> 1..35
<223> /note="Phosphorothioate linkages"

<400> 25
gaagttttga ggttttgaag ttgttggtag tggtg                                35


<210> 26
<211> 40
<212> DNA
<213> Artificial Sequence


<220> 
<223> 40mer 1

<220> 
<221> misc_feature
<222> 1..40
<223> /note="Phosphorothioate linkages"

<400> 26
gagaagtttt gaggttttga agttgttggt agtggtggtg                           40


<210> 27
<211> 40
<212> DNA
<213> Artificial Sequence


<220> 
<223> 40mer 2

<220> 
<221> misc_feature
<222> 1..40
<223> /note="Phosphorothioate linkages"

<400> 27
gaagaagttt tgaggttttg aagttgttgg tagtggtgtg                           40


