               SEQUENCE LISTING

<110> INSTITUT PASTEUR

<120> HUMAN NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST SARS-CoV-2  AND USES THEREOF

<130> PR92597

<160> 184

<170> BiSSAP 1.3.6

<210> 1
<211> 1273
<212> PRT
<213> SARS-Cov2


<400> 1
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Phe Leu 
        355                 360                 365             
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                1005            
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                1015                1020                
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                1030                1035                1040
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                1050                1055    
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                1065                1070        
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                1080                1085            
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                1095                1100                
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                1110                1115                1120
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                1130                1135    
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                1145                1150        
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                1160                1165            
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                1175                1180                
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                1190                1195                1200
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                1210                1215    
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                1225                1230        
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                1240                1245            
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                1255                1260                
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                1270            

<210> 2
<211> 200
<212> PRT
<213> artificial sequence


<220> 
<223> SARS-CoV-2 Spike receptor-binding domain (RBD)

<400> 2
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      
Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          
Ala Asp Tyr Ser Phe Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              
Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  
Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  
Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      
Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         
Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             
Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 
Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 
Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     
Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         
Thr Val Cys Gly Pro Lys Gly Ser 
        195                 200 

<210> 3
<211> 123
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.1169 VH)

<400> 3
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Ser 
            20                  25                  30          
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Pro Tyr Cys Ser Gly Gly Thr Cys Leu Asp Gly Phe Asp Ile 
            100                 105                 110         
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             

<210> 4
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> synthetic polypeptide (Cv2.1169 VL)

<400> 4
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Ser Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 5
<211> 117
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.1353 VH)

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Leu Gly Pro Met Gly Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 6
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> synthetic polypeptide (Cv2.1353 VL)

<400> 6
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Asp Pro Pro 
                85                  90                  95      
Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             

<210> 7
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> synthetic polypeptide (Cv2.3194 VH)

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Thr Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Pro Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 8
<211> 104
<212> PRT
<213> Artificial Sequence


<220> 
<223> synthetic polypeptide (Cv2.3194 VL)

<400> 8
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Gly Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Gly Val Thr Phe Gly 
                85                  90                  95      
Gly Gly Thr Lys Val Glu Ile Lys 
            100                 

<210> 9
<211> 117
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.3235 VH)

<400> 9
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Arg Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Gly Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 10
<211> 108
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.3235 VL)

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Thr Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Leu Asp Ser Tyr Pro Pro 
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             

<210> 11
<211> 117
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.5213 VH)

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Leu Asn Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Ala Thr 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 12
<211> 108
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.5213 VL)

<400> 12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Tyr Ser Pro 
                85                  90                  95      
Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             

<210> 13
<211> 452
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.1169 full length heavy chain)

<400> 13
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Ser 
            20                  25                  30          
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Pro Tyr Cys Ser Gly Gly Thr Cys Leu Asp Gly Phe Asp Ile 
            100                 105                 110         
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210> 14
<211> 215
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.1169 full length light chain)

<400> 14
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Ser Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 15
<211> 446
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.1353 full length heavy chain)

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Leu Gly Pro Met Gly Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

<210> 16
<211> 215
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.1353 full length light chain)

<400> 16
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Asp Pro Pro 
                85                  90                  95      
Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 17
<211> 446
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.3194 full length heavy chain)

<400> 17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Thr Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Pro Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

<210> 18
<211> 211
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.3194 full length light chain)

<400> 18
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Gly Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Gly Val Thr Phe Gly 
                85                  90                  95      
Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
            100                 105                 110         
Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
        115                 120                 125             
Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 140                 
Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
145                 150                 155                 160 
Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
                165                 170                 175     
Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
            180                 185                 190         
Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
        195                 200                 205             
Gly Glu Cys 
    210     

<210> 19
<211> 446
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.3235 full length heavy chain)

<400> 19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Arg Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Gly Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

<210> 20
<211> 215
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.3235 full length light chain)

<400> 20
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Thr Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Leu Asp Ser Tyr Pro Pro 
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 21
<211> 446
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.5213 full length heavy chain)

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Leu Asn Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Ala Thr 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

<210> 22
<211> 215
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic polypeptide (Cv2.5213 full length light chain)

<400> 22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Tyr Ser Pro 
                85                  90                  95      
Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 23
<211> 5
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 CDR-H1)

<400> 23
Thr Ser Ala Val Gln 
1               5   

<210> 24
<211> 17
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 CDR-H2)

<400> 24
Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Glu 
    

<210> 25
<211> 14
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 CDR-H3)

<400> 25
Pro Tyr Cys Ser Gly Gly Thr Cys Leu Asp Gly Phe Asp Ile 
1               5                   10                  

<210> 26
<211> 12
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 CDR-L1)

<400> 26
Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu Ala 
1               5                   10          

<210> 27
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169-CDR-L2)

<400> 27
Ser Ala Ser Ser Arg Ala Thr 
1               5           

<210> 28
<211> 9
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 CDR-L3)

<400> 28
Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   

<210> 29
<211> 5
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 CDR-H1)

<400> 29
Ser Asn Tyr Met Asn 
1               5   

<210> 30
<211> 16
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 CDR-H2)

<400> 30
Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 31
<211> 9
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 CDR-H3)

<400> 31
Asp Leu Gly Pro Met Gly Phe Asp Ile 
1               5                   

<210> 32
<211> 11
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 CDR-L1)

<400> 32
Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 33
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353-CDR-L2)

<400> 33
Ala Ala Ser Thr Leu Gln Ser 
1               5           

<210> 34
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 CDR-L3)

<400> 34
Gln Gln Leu Asn Ser Asp Pro Pro Val Thr 
1               5                   10  

<210> 35
<211> 5
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 CDR-H1)

<400> 35
Ser Asn Tyr Met Ser 
1               5   

<210> 36
<211> 16
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 CDR-H2)

<400> 36
Val Ile Tyr Pro Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 37
<211> 9
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 CDR-H3)

<400> 37
Asp Leu Val Val Tyr Gly Met Asp Val 
1               5                   

<210> 38
<211> 12
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 CDR-L1)

<400> 38
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          

<210> 39
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194-CDR-L2)

<400> 39
Gly Ala Ser Ser Arg Ala Thr 
1               5           

<210> 40
<211> 5
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 CDR-L3)

<400> 40
Gln Gln Gly Val Thr 
1               5   

<210> 41
<211> 5
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 CDR-H1)

<400> 41
Arg Asn Tyr Met Ser 
1               5   

<210> 42
<211> 16
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 CDR-H2)

<400> 42
Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 43
<211> 9
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 CDR-H3)

<400> 43
Asp Gly Asp Tyr Tyr Gly Met Asp Val 
1               5                   

<210> 44
<211> 11
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 CDR-L1)

<400> 44
Arg Ala Ser Gln Gly Ile Ser Ser Phe Leu Ala 
1               5                   10      

<210> 45
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235-CDR-L2)

<400> 45
Gly Ala Ser Thr Leu Gln Ser 
1               5           

<210> 46
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 CDR-L3)

<400> 46
Gln Arg Leu Asp Ser Tyr Pro Pro Ile Thr 
1               5                   10  

<210> 47
<211> 5
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 CDR-H1)

<400> 47
Ser Asn Tyr Met Ser 
1               5   

<210> 48
<211> 16
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 CDR-H2)

<400> 48
Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      



<210> 49
<211> 9
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 CDR-H3)

<400> 49
Asp Leu Asn Tyr Tyr Gly Met Asp Val 
1               5                   

<210> 50
<211> 11
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 CDR-L1)

<400> 50
Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      

<210> 51
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213-CDR-L2)

<400> 51
Ala Ala Ser Thr Leu Gln Ser 
1               5           

<210> 52
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 CDR-L3)

<400> 52
Gln Gln Leu Asp Ser Tyr Ser Pro Phe Thr 
1               5                   10  

<210> 53
<211> 30
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 H-FW1)

<400> 53
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr 
            20                  25                  30  

<210> 54
<211> 14
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 H-FW2)

<400> 54
Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 55
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 H-FW3)

<400> 55
Arg Val Thr Ile Thr Arg Asp Met Ser Thr Thr Thr Ala Tyr Met Glu 
1               5                   10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          



<210> 56
<211> 11
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 H-FW4)

<400> 56
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      

<210> 57
<211> 23
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 L-FW1)

<400> 57
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys 
            20              

<210> 58
<211> 15
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 L-FW2)

<400> 58
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 59
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 L-FW3)

<400> 59
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 60
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1169 L-FW4)

<400> 60
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 61
<211> 30
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 H-FW1)

<400> 61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser 
            20                  25                  30  

<210> 62
<211> 14
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 H-FW2)

<400> 62
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 63
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 H-FW3)

<400> 63
Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          



<210> 64
<211> 11
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 H-FW4)

<400> 64
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      

<210> 65
<211> 23
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 L-FW1)

<400> 65
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210> 66
<211> 15
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 L-FW2)

<400> 66
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 67
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 L-FW3)

<400> 67
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 68
<211> 10
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic peptide (Cv2.1353 L-FW4)

<400> 68
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
1               5                   10  

<210> 69
<211> 30
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 H-FW1)

<400> 69
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Thr 
            20                  25                  30  

<210> 70
<211> 14
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 H-FW2)

<400> 70
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 71
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 H-FW3)

<400> 71
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          



<210> 72
<211> 11
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 H-FW4)

<400> 72
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 73
<211> 23
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 L-FW1)

<400> 73
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys 
            20              

<210> 74
<211> 15
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 L-FW2)

<400> 74
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 75
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 L-FW3)

<400> 75
Gly Ile Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Ile Tyr Tyr Cys 
            20                  25                  30          



<210> 76
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3194 L-FW4)

<400> 76
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210> 77
<211> 30
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 H-FW1)

<400> 77
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  

<210> 78
<211> 14
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 H-FW2)

<400> 78
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 79
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 H-FW3)

<400> 79
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          



<210> 80
<211> 11
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 H-FW4)

<400> 80
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 81
<211> 23
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 L-FW1)

<400> 81
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210> 82
<211> 15
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 L-FW2)

<400> 82
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 83
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 L-FW3)

<400> 83
Gly Val Thr Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 84
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.3235 L-FW4)

<400> 84
Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  

<210> 85
<211> 30
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 H-FW1)

<400> 85
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  

<210> 86
<211> 14
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 H-FW2)

<400> 86
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 87
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 H-FW3)

<400> 87
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          



<210> 88
<211> 11
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 H-FW4)

<400> 88
Trp Gly Gln Gly Ala Thr Val Thr Val Ser Ser 
1               5                   10      

<210> 89
<211> 23
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 L-FW1)

<400> 89
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210> 90
<211> 15
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 L-FW2)

<400> 90
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 91
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 L-FW3)

<400> 91
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 92
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> synthetic peptide (Cv2.5213 L-FW4)

<400> 92
Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
1               5                   10  

<210> 93
<211> 369
<212> DNA
<213> Artificial sequence


<220> 
<223> synthetic polynucleotide (Cv2.1169 VH)

<400> 93
caggtgcagc tggtgcagtc tgggcctgag gtgaagaagc ctgggacctc agtgaaggtc      60

tcctgcaagg cttctggatt cacctttact acctctgctg tgcagtgggt gcgacaggct     120

cgtggacaac gccttgagtg gataggctgg atcgtcgttg gcagtggtaa cacaaactac     180

gcacagaagt tccaggaaag agtcaccatt accagggaca tgtccacaac cacagcctac     240

atggagctga gcagcctgag atccgaggac acggccgtgt attactgtgc ggcgccatat     300

tgtagtggtg ggacctgctt agatggtttt gatatctggg gccaagggac aatggtcacc     360

gtctcttca                                                             369


<210> 94
<211> 324
<212> DNA
<213> Artificial sequence


<220> 
<223> synthetic polynucleotide (Cv2.1169 VL)

<400> 94
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccggggga aagagccacc      60

ctctcctgca gggccagtca gagtgttagc cgcagctact tagcctggta ccagcagaaa     120

cctggccagg ctcccaggct cctcatctat agtgcatcca gcagggccac tggcatccca     180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag     240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc     300

caagggacca aggtggagat caaa                                            324


<210> 95
<211> 351
<212> DNA
<213> Artificial sequence


<220> 
<223> synthetic polynucleotide (Cv2.1353 VH)

<400> 95
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc      60

tcctgtgcag cctctggagt caccgtcagt agcaactaca tgaactgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac attctacgca     180

gactccgtga agggccgatt catcatctcc agagacaatt ccaagaacac gctgtatctt     240

caaatgaaca gcctgaaaac tgaggacacg gctgtgtatt actgtgcgag agatttaggg     300

cccatgggtt ttgatatctg gggccagggg acaatggtca ccgtctcttc a              351


<210> 96
<211> 324
<212> DNA
<213> Artificial sequence


<220> 
<223> synthetic polynucleotide (Cv2.1353 VL)

<400> 96
gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca     120

gggaaagccc caaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca     180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct     240

gaagattttg caacttatta ctgtcaacag cttaatagtg atcctccggt cactttcggc     300

cctgggacca aagtggatat caaa                                            324


<210> 97
<211> 351
<212> DNA
<213> Artificial sequence


<220> 
<223> synthetic polynucleotide (Cv2.3194 VH)

<400> 97
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc      60

tcctgtgcag cctctgggat caccgtcact agcaactaca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagtt atttatcccg gtggtagcac attctacgca     180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt     240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatcttgta     300

gtatacggta tggacgtctg gggccaaggg accacggtca ccgtctcctc a              351


<210> 98
<211> 312
<212> DNA
<213> Artificial sequence


<220> 
<223> synthetic polynucleotide (Cv2.3194 VL)

<400> 98
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    180

ggcaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcaatcta ttactgtcaa caaggggtca ctttcggcgg agggaccaag    300

gtggagatca aa                                                        312


<210> 99
<211> 351
<212> DNA
<213> artificial sequence


<220> 
<223> synthetic polynucleotide (Cv2.3235_VH)

<400> 99
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc      60

tcctgtgcag cctctgggtt caccgtcagt aggaactaca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac attctacgca     180

gactccgtga agggccgatt caccatctcc agagacaact ccaagaacac gctgtatctt     240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agatggggac     300

tactacggta tggacgtctg gggccaaggg accacggtca ccgtctcctc a              351


<210> 100
<211> 324
<212> DNA
<213> Artificial sequence


<220> 
<223> synthetic polynucleotide (Cv2.3235 VL)

<400> 100
gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc gggccagtca gggcattagc agttttttag cctggtatca gcaaaaacca     120

gggaaagccc ctaagctcct gatctatggt gcatccactt tgcaaagtgg ggtcacatca     180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct     240

gaagattttg caacttatta ctgtcaacgg cttgatagtt accctccgat caccttcggc     300

caagggacac gactggagat taaa                                            324


<210> 101
<211> 351
<212> DNA
<213> Artificial sequence


<220> 
<223> synthetic polynucleotide (Cv2.5213 VH)

<400> 101
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc      60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct     120

ccagggaagg ggctggagtg ggtctcactt atctatagcg gtggtagcac atactacgca     180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt     240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag ggacctgaac     300

tactacggta tggacgtctg gggccaaggg gccacggtca ccgtctcctc a              351


<210> 102
<211> 324
<212> DNA
<213> Artificial sequence


<220> 
<223> synthetic polynucleotide (Cv2.5213 VL)

<400> 102
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca     120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca     180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct     240

gaagattttg caacttatta ctgtcaacag cttgatagtt actctccatt cactttcggc     300

cctgggacca aagtggatat caaa                                            324


<210> 103
<211> 644
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (ACE2 ectodomain)

<400> 103
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp 
            20                  25                  30          
Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala 
        35                  40                  45              
Ser Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met 
    50                  55                  60                  
Asn Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr 
65                  70                  75                  80  
Leu Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys 
                85                  90                  95      
Leu Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu 
            100                 105                 110         
Asp Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile 
        115                 120                 125             
Tyr Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu 
    130                 135                 140                 
Leu Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr 
145                 150                 155                 160 
Asn Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys 
                165                 170                 175     
Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met 
            180                 185                 190         
Ala Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp 
        195                 200                 205             
Tyr Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu 
    210                 215                 220                 
Ile Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu 
225                 230                 235                 240 
His Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser 
                245                 250                 255     
Tyr Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met 
            260                 265                 270         
Trp Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly 
        275                 280                 285             
Gln Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp 
    290                 295                 300                 
Asp Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val 
305                 310                 315                 320 
Gly Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr 
                325                 330                 335     
Asp Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp 
            340                 345                 350         
Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met 
        355                 360                 365             
Asp Asp Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp 
    370                 375                 380                 
Met Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu 
385                 390                 395                 400 
Gly Phe His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr 
                405                 410                 415     
Pro Lys His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu 
            420                 425                 430         
Asp Asn Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile 
        435                 440                 445             
Val Gly Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met 
    450                 455                 460                 
Val Phe Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp 
465                 470                 475                 480 
Glu Met Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp 
                485                 490                 495     
Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr 
            500                 505                 510         
Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln 
        515                 520                 525             
Glu Ala Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys 
    530                 535                 540                 
Asp Ile Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu 
545                 550                 555                 560 
Arg Leu Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val 
                565                 570                 575     
Gly Ala Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro 
            580                 585                 590         
Leu Phe Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp 
        595                 600                 605             
Ser Thr Asp Trp Ser Pro Tyr Ala Asp Gly Ser Gly Leu Val Pro Arg 
    610                 615                 620                 
Gly Ser His His His His His His His His Ser Ala Trp Ser His Pro 
625                 630                 635                 640 
Gln Phe Glu Lys 
                

<210> 104
<211> 457
<212> PRT
<213> artificial sequence


<220> 
<223> Synthetic polypeptide (SARS-CoV-2 Nucleocapsid protein (N))

<400> 104
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Gln Arg Asn Ala Pro Arg Ile Thr Phe Gly Gly Pro Ser 
            20                  25                  30          
Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg Ser Gly Ala Arg Ser 
        35                  40                  45              
Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn Thr Ala Ser Trp Phe 
    50                  55                  60                  
Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu Lys Phe Pro Arg Gly 
65                  70                  75                  80  
Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro Asp Asp Gln Ile Gly 
                85                  90                  95      
Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly Gly Asp Gly Lys Met 
            100                 105                 110         
Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr Leu Gly Thr Gly Pro 
        115                 120                 125             
Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp Gly Ile Ile Trp Val 
    130                 135                 140                 
Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp His Ile Gly Thr Arg 
145                 150                 155                 160 
Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln Leu Pro Gln Gly Thr 
                165                 170                 175     
Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser Arg Gly Gly Ser Gln 
            180                 185                 190         
Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn Ser Ser Arg Asn Ser 
        195                 200                 205             
Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala Arg Met Ala Gly Asn 
    210                 215                 220                 
Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu Asp Arg Leu Asn Gln 
225                 230                 235                 240 
Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln Gln Gln Gly Gln Thr 
                245                 250                 255     
Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys Lys Pro Arg Gln Lys 
            260                 265                 270         
Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln Ala Phe Gly Arg Arg 
        275                 280                 285             
Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp Gln Glu Leu Ile Arg 
    290                 295                 300                 
Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile Ala Gln Phe Ala Pro 
305                 310                 315                 320 
Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile Gly Met Glu Val Thr 
                325                 330                 335     
Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala Ile Lys Leu Asp Asp 
            340                 345                 350         
Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu Leu Asn Lys His Ile 
        355                 360                 365             
Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro Lys Lys Asp Lys Lys 
    370                 375                 380                 
Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln Arg Gln Lys Lys Gln 
385                 390                 395                 400 
Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe Ser Lys 
                405                 410                 415     
Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser Thr Gln Ala Gly Ser 
            420                 425                 430         
His His His His His His His His Gly Ser Gly Leu Asn Asp Ile Phe 
        435                 440                 445             
Glu Ala Gln Lys Ile Glu Trp His Glu 
    450                 455         

<210> 105
<211> 22
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic peptide (SARS-CoV-2 Fusion peptide (FP))

<400> 105
Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
1               5                   10                  15      
Asp Ala Gly Phe Ile Lys 
            20          

<210> 106
<211> 1276
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (SARS-CoV-2 Spike ectodomain (tri-S))

<400> 106
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Phe Leu 
        355                 360                 365             
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     
Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                1005            
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                1015                1020                
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                1030                1035                1040
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                1050                1055    
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                1065                1070        
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                1080                1085            
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                1095                1100                
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                1110                1115                1120
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                1130                1135    
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                1145                1150        
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                1160                1165            
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                1175                1180                
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                1190                1195                1200
Gln Glu Leu Gly Lys Tyr Glu Gln Gly Ser Gly Tyr Ile Pro Glu Ala 
                1205                1210                1215    
Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
            1220                1225                1230        
Leu Ser Thr Phe Leu Gly Gly Ser His His His His His His His His 
        1235                1240                1245            
Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn 
    1250                1255                1260                
Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1265                1270                1275    

<210> 107
<211> 696
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (SARS-CoV-2 S1 domain)

<400> 107
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
            20                  25                  30          
Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
        35                  40                  45              
Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
    50                  55                  60                  
Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
65                  70                  75                  80  
Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
                85                  90                  95      
Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
            100                 105                 110         
Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
        115                 120                 125             
Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
    130                 135                 140                 
Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
145                 150                 155                 160 
Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
                165                 170                 175     
Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
            180                 185                 190         
Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
        195                 200                 205             
Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
    210                 215                 220                 
Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
225                 230                 235                 240 
Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
                245                 250                 255     
Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
            260                 265                 270         
Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
        275                 280                 285             
Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
    290                 295                 300                 
Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
305                 310                 315                 320 
Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
                325                 330                 335     
Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
            340                 345                 350         
Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
        355                 360                 365             
Tyr Ser Phe Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
    370                 375                 380                 
Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
385                 390                 395                 400 
Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
                405                 410                 415     
Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
            420                 425                 430         
Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
        435                 440                 445             
Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
    450                 455                 460                 
Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
465                 470                 475                 480 
Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
                485                 490                 495     
Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
            500                 505                 510         
Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
        515                 520                 525             
Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
    530                 535                 540                 
Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
545                 550                 555                 560 
Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
                565                 570                 575     
Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
            580                 585                 590         
Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
        595                 600                 605             
Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
    610                 615                 620                 
Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
625                 630                 635                 640 
Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
                645                 650                 655     
Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
            660                 665                 670         
Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Gly Ser 
        675                 680                 685             
His His His His His His His His 
    690                 695     

<210> 108
<211> 263
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (SARS-CoV-2 RBD domain)

<400> 108
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          
Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              
Ser Asn Cys Val Ala Asp Tyr Ser Phe Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  
Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  
Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      
Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
            100                 105                 110         
Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             
Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    130                 135                 140                 
Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 
Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
                165                 170                 175     
Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
            180                 185                 190         
Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             
His Ala Pro Ala Thr Val Cys Gly Pro Lys Gly Ser Gly Leu Val Pro 
    210                 215                 220                 
Arg Gly Ser His His His His His His His His Ser Ala Trp Ser His 
225                 230                 235                 240 
Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                245                 250                 255     
Gln Lys Ile Glu Trp His Glu 
            260             

<210> 109
<211> 263
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (SARS-CoV-2 variant B.1.1.7 RBD domain)

<400> 109
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          
Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              
Ser Asn Cys Val Ala Asp Tyr Ser Phe Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  
Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  
Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      
Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
            100                 105                 110         
Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             
Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    130                 135                 140                 
Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 
Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
                165                 170                 175     
Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly 
            180                 185                 190         
Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             
His Ala Pro Ala Thr Val Cys Gly Pro Lys Gly Ser Gly Leu Val Pro 
    210                 215                 220                 
Arg Gly Ser His His His His His His His His Ser Ala Trp Ser His 
225                 230                 235                 240 
Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                245                 250                 255     
Gln Lys Ile Glu Trp His Glu 
            260             

<210> 110
<211> 263
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (SARS-CoV-2 variant B.1.351 RBD domain)

<400> 110
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          
Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              
Ser Asn Cys Val Ala Asp Tyr Ser Phe Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  
Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  
Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      
Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn 
            100                 105                 110         
Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             
Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    130                 135                 140                 
Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 
Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe 
                165                 170                 175     
Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly 
            180                 185                 190         
Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             
His Ala Pro Ala Thr Val Cys Gly Pro Lys Gly Ser Gly Leu Val Pro 
    210                 215                 220                 
Arg Gly Ser His His His His His His His His Ser Ala Trp Ser His 
225                 230                 235                 240 
Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                245                 250                 255     
Gln Lys Ile Glu Trp His Glu 
            260             

<210> 111
<211> 263
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (SARS-CoV-2 variant P.1 RBD domain)

<400> 111
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          
Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              
Ser Asn Cys Val Ala Asp Tyr Ser Phe Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  
Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  
Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      
Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Thr Ile Ala Asp Tyr Asn 
            100                 105                 110         
Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             
Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    130                 135                 140                 
Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 
Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe 
                165                 170                 175     
Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly 
            180                 185                 190         
Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             
His Ala Pro Ala Thr Val Cys Gly Pro Lys Gly Ser Gly Leu Val Pro 
    210                 215                 220                 
Arg Gly Ser His His His His His His His His Ser Ala Trp Ser His 
225                 230                 235                 240 
Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                245                 250                 255     
Gln Lys Ile Glu Trp His Glu 
            260             

<210> 112
<211> 322
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (SARS-CoV-2 S1 NTD domain)

<400> 112
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 
Ser Gly Ser Gly Leu Val Pro Arg Gly Ser His His His His His His 
305                 310                 315                 320 
His His 
        

<210> 113
<211> 238
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (SARS-CoV-2 S1 connecting domain (CD))

<400> 113
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
            20                  25                  30          
Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Gly Gly Gly Ser Gly 
        35                  40                  45              
Gly Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
    50                  55                  60                  
Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
65                  70                  75                  80  
Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
                85                  90                  95      
Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
            100                 105                 110         
Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
        115                 120                 125             
Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
    130                 135                 140                 
Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
145                 150                 155                 160 
Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
                165                 170                 175     
Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
            180                 185                 190         
Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
        195                 200                 205             
Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Gly Ser Gly 
    210                 215                 220                 
Leu Val Pro Arg Gly Ser His His His His His His His His 
225                 230                 235             

<210> 114
<211> 582
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (SARS-CoV-2 S2 domain)

<400> 114
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
            20                  25                  30          
Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
        35                  40                  45              
Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
    50                  55                  60                  
Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
65                  70                  75                  80  
Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
                85                  90                  95      
Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
            100                 105                 110         
Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
        115                 120                 125             
Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
    130                 135                 140                 
Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
145                 150                 155                 160 
Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
                165                 170                 175     
Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
            180                 185                 190         
Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
        195                 200                 205             
Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
    210                 215                 220                 
Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe 
225                 230                 235                 240 
Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
                245                 250                 255     
Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
            260                 265                 270         
Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
        275                 280                 285             
Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
    290                 295                 300                 
Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro 
305                 310                 315                 320 
Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln 
                325                 330                 335     
Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile 
            340                 345                 350         
Arg Ala Ser Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu 
        355                 360                 365             
Gly Gln Ser Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met 
    370                 375                 380                 
Ser Phe Pro Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr 
385                 390                 395                 400 
Tyr Val Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys 
                405                 410                 415     
His Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 
            420                 425                 430         
Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile 
        435                 440                 445             
Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile 
    450                 455                 460                 
Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp 
465                 470                 475                 480 
Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro 
                485                 490                 495     
Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn 
            500                 505                 510         
Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn 
        515                 520                 525             
Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Gly Ser 
    530                 535                 540                 
Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
545                 550                 555                 560 
Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Gly Ser His His 
                565                 570                 575     
His His His His His His 
            580         

<210> 115
<211> 1322
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (CoV-OC43 Spike ectodomain)

<400> 115
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      
Met Leu Val Ala Ser Val Leu Ala Val Ile Gly Asp Leu Lys Cys Thr 
            20                  25                  30          
Ser Asp Asn Ile Asn Asp Lys Asp Thr Gly Pro Pro Pro Ile Ser Thr 
        35                  40                  45              
Asp Thr Val Asp Val Thr Asn Gly Leu Gly Thr Tyr Tyr Val Leu Asp 
    50                  55                  60                  
Arg Val Tyr Leu Asn Thr Thr Leu Phe Leu Asn Gly Tyr Tyr Pro Thr 
65                  70                  75                  80  
Ser Gly Ser Thr Tyr Arg Asn Met Ala Leu Lys Gly Ser Val Leu Leu 
                85                  90                  95      
Ser Arg Leu Trp Phe Lys Pro Pro Phe Leu Ser Asp Phe Ile Asn Gly 
            100                 105                 110         
Ile Phe Ala Lys Val Lys Asn Thr Lys Val Ile Lys Asp Arg Val Met 
        115                 120                 125             
Tyr Ser Glu Phe Pro Ala Ile Thr Ile Gly Ser Thr Phe Val Asn Thr 
    130                 135                 140                 
Ser Tyr Ser Val Val Val Gln Pro Arg Thr Ile Asn Ser Thr Gln Asp 
145                 150                 155                 160 
Gly Asp Asn Lys Leu Gln Gly Leu Leu Glu Val Ser Val Cys Gln Tyr 
                165                 170                 175     
Asn Met Cys Glu Tyr Pro Gln Thr Ile Cys His Pro Asn Leu Gly Asn 
            180                 185                 190         
His Arg Lys Glu Leu Trp His Leu Asp Thr Gly Val Val Ser Cys Leu 
        195                 200                 205             
Tyr Lys Arg Asn Phe Thr Tyr Asp Val Asn Ala Asp Tyr Leu Tyr Phe 
    210                 215                 220                 
His Phe Tyr Gln Glu Gly Gly Thr Phe Tyr Ala Tyr Phe Thr Asp Thr 
225                 230                 235                 240 
Gly Val Val Thr Lys Phe Leu Phe Asn Val Tyr Leu Gly Met Ala Leu 
                245                 250                 255     
Ser His Tyr Tyr Val Met Pro Leu Thr Cys Asn Ser Lys Leu Thr Leu 
            260                 265                 270         
Glu Tyr Trp Val Thr Pro Leu Thr Ser Arg Gln Tyr Leu Leu Ala Phe 
        275                 280                 285             
Asn Gln Asp Gly Ile Ile Phe Asn Ala Val Asp Cys Met Ser Asp Phe 
    290                 295                 300                 
Met Ser Glu Ile Lys Cys Lys Thr Gln Ser Ile Ala Pro Pro Thr Gly 
305                 310                 315                 320 
Val Tyr Glu Leu Asn Gly Tyr Thr Val Gln Pro Ile Ala Asp Val Tyr 
                325                 330                 335     
Arg Arg Lys Pro Asn Leu Pro Asn Cys Asn Ile Glu Ala Trp Leu Asn 
            340                 345                 350         
Asp Lys Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Thr Phe Ser 
        355                 360                 365             
Asn Cys Asn Phe Asn Met Ser Ser Leu Met Ser Phe Ile Gln Ala Asp 
    370                 375                 380                 
Ser Phe Thr Cys Asn Asn Ile Asp Ala Ala Lys Ile Tyr Gly Met Cys 
385                 390                 395                 400 
Phe Ser Ser Ile Thr Ile Asp Lys Phe Ala Ile Pro Asn Gly Arg Lys 
                405                 410                 415     
Val Asp Leu Gln Leu Gly Asn Leu Gly Tyr Leu Gln Ser Phe Asn Tyr 
            420                 425                 430         
Arg Ile Asp Thr Thr Ala Thr Ser Cys Gln Leu Tyr Tyr Asn Leu Pro 
        435                 440                 445             
Ala Ala Asn Val Ser Val Ser Arg Phe Asn Pro Ser Thr Trp Asn Lys 
    450                 455                 460                 
Arg Phe Gly Phe Ile Glu Asp Ser Val Phe Lys Pro Arg Pro Ala Gly 
465                 470                 475                 480 
Val Leu Thr Asn His Asp Val Val Tyr Ala Gln His Cys Phe Lys Ala 
                485                 490                 495     
Pro Lys Asn Phe Cys Pro Cys Lys Leu Asn Gly Ser Cys Val Gly Ser 
            500                 505                 510         
Gly Pro Gly Lys Asn Asn Gly Ile Gly Thr Cys Pro Ala Gly Thr Asn 
        515                 520                 525             
Tyr Leu Thr Cys Asp Asn Leu Cys Thr Pro Asp Pro Ile Thr Phe Thr 
    530                 535                 540                 
Gly Thr Tyr Lys Cys Pro Gln Thr Lys Ser Leu Val Gly Ile Gly Glu 
545                 550                 555                 560 
His Cys Ser Gly Leu Ala Val Lys Ser Asp Tyr Cys Gly Gly Asn Ser 
                565                 570                 575     
Cys Thr Cys Arg Pro Gln Ala Phe Leu Gly Trp Ser Ala Asp Ser Cys 
            580                 585                 590         
Leu Gln Gly Asp Lys Cys Asn Ile Phe Ala Asn Phe Ile Leu His Asp 
        595                 600                 605             
Val Asn Ser Gly Leu Thr Cys Ser Thr Asp Leu Gln Lys Ala Asn Thr 
    610                 615                 620                 
Asp Ile Ile Leu Gly Val Cys Val Asn Tyr Asp Leu Tyr Gly Ile Leu 
625                 630                 635                 640 
Gly Gln Gly Ile Phe Val Glu Val Asn Ala Thr Tyr Tyr Asn Ser Trp 
                645                 650                 655     
Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn Leu Tyr Gly Phe Arg Asp 
            660                 665                 670         
Tyr Ile Thr Asn Arg Thr Phe Met Ile Arg Ser Cys Tyr Ser Gly Arg 
        675                 680                 685             
Val Ser Ala Ala Phe His Ala Asn Ser Ser Glu Pro Ala Leu Leu Phe 
    690                 695                 700                 
Arg Asn Ile Lys Cys Asn Tyr Val Phe Asn Asn Ser Leu Thr Arg Gln 
705                 710                 715                 720 
Leu Gln Pro Ile Asn Tyr Phe Asp Ser Tyr Leu Gly Cys Val Val Asn 
                725                 730                 735     
Ala Tyr Asn Ser Thr Ala Ile Ser Val Gln Thr Cys Asp Leu Thr Val 
            740                 745                 750         
Gly Ser Gly Tyr Cys Val Asp Tyr Ser Lys Asn Gly Gly Ser Gly Gly 
        755                 760                 765             
Ala Ile Thr Thr Gly Tyr Arg Phe Thr Asn Phe Glu Pro Phe Thr Val 
    770                 775                 780                 
Asn Ser Val Asn Asp Ser Leu Glu Pro Val Gly Gly Leu Tyr Glu Ile 
785                 790                 795                 800 
Gln Ile Pro Ser Glu Phe Thr Ile Gly Asn Met Val Glu Phe Ile Gln 
                805                 810                 815     
Thr Ser Ser Pro Lys Val Thr Ile Asp Cys Ala Ala Phe Val Cys Gly 
            820                 825                 830         
Asp Tyr Ala Ala Cys Lys Ser Gln Leu Val Glu Tyr Gly Ser Phe Cys 
        835                 840                 845             
Asp Asn Ile Asn Ala Ile Leu Thr Glu Val Asn Glu Leu Leu Asp Thr 
    850                 855                 860                 
Thr Gln Leu Gln Val Ala Asn Ser Leu Met Asn Gly Val Thr Leu Ser 
865                 870                 875                 880 
Thr Lys Leu Lys Asp Gly Val Asn Phe Asn Val Asp Asp Ile Asn Phe 
                885                 890                 895     
Ser Pro Val Leu Gly Cys Leu Gly Ser Glu Cys Ser Lys Ala Ser Ser 
            900                 905                 910         
Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp Lys Val Lys Leu Ser Asp 
        915                 920                 925             
Val Gly Phe Val Glu Ala Tyr Asn Asn Cys Thr Gly Gly Ala Glu Ile 
    930                 935                 940                 
Arg Asp Leu Ile Cys Val Gln Ser Tyr Lys Gly Ile Lys Val Leu Pro 
945                 950                 955                 960 
Pro Leu Leu Ser Glu Asn Gln Phe Ser Gly Tyr Thr Leu Ala Ala Thr 
                965                 970                 975     
Ser Ala Ser Leu Phe Pro Pro Trp Thr Ala Ala Ala Gly Val Pro Phe 
            980                 985                 990         
Tyr Leu Asn Val Gln Tyr Arg Ile Asn Gly Leu Gly Val Thr Met Asp 
        995                 1000                1005            
Val Leu Ser Gln Asn Gln Lys Leu Ile Ala Asn Ala Phe Asn Asn Ala 
    1010                1015                1020                
Leu Tyr Ala Ile Gln Glu Gly Phe Asp Ala Thr Asn Ser Ala Leu Val 
1025                1030                1035                1040
Lys Ile Gln Ala Val Val Asn Ala Asn Ala Glu Ala Leu Asn Asn Leu 
                1045                1050                1055    
Leu Gln Gln Leu Ser Asn Arg Phe Gly Ala Ile Ser Ala Ser Leu Gln 
            1060                1065                1070        
Glu Ile Leu Ser Arg Leu Asp Ala Leu Glu Ala Glu Ala Gln Ile Asp 
        1075                1080                1085            
Arg Leu Ile Asn Gly Arg Leu Thr Ala Leu Asn Ala Tyr Val Ser Gln 
    1090                1095                1100                
Gln Leu Ser Asp Ser Thr Leu Val Lys Phe Ser Ala Ala Gln Ala Met 
1105                1110                1115                1120
Glu Lys Val Asn Glu Cys Val Lys Ser Gln Ser Ser Arg Ile Asn Phe 
                1125                1130                1135    
Cys Gly Asn Gly Asn His Ile Ile Ser Leu Val Gln Asn Ala Pro Tyr 
            1140                1145                1150        
Gly Leu Tyr Phe Ile His Phe Ser Tyr Val Pro Thr Lys Tyr Val Thr 
        1155                1160                1165            
Ala Arg Val Ser Pro Gly Leu Cys Ile Ala Gly Asp Arg Gly Ile Ala 
    1170                1175                1180                
Pro Lys Ser Gly Tyr Phe Val Asn Val Asn Asn Thr Trp Met Tyr Thr 
1185                1190                1195                1200
Gly Ser Gly Tyr Tyr Tyr Pro Glu Pro Ile Thr Glu Asn Asn Val Val 
                1205                1210                1215    
Val Met Ser Thr Cys Ala Val Asn Tyr Thr Lys Ala Pro Tyr Val Met 
            1220                1225                1230        
Leu Asn Thr Ser Ile Pro Asn Leu Pro Asp Phe Lys Glu Glu Leu Asp 
        1235                1240                1245            
Gln Trp Phe Lys Asn Gln Thr Ser Val Ala Pro Asp Leu Ser Leu Asp 
    1250                1255                1260                
Tyr Ile Asn Val Thr Phe Leu Asp Leu Leu Ile Lys Arg Met Lys Gln 
1265                1270                1275                1280
Ile Glu Asp Lys Ile Glu Glu Ile Glu Ser Lys Gln Lys Lys Ile Glu 
                1285                1290                1295    
Asn Glu Ile Ala Arg Ile Lys Lys Ile Lys Leu Val Pro Arg Gly Ser 
            1300                1305                1310        
Leu Glu Trp Ser His Pro Gln Phe Glu Lys 
        1315                1320        

<210> 116
<211> 1328
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (CoV-HKU1 Spike ectodomain)

<400> 116
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Val Ile Gly Asp Phe Asn Cys Thr Asn Ser Phe Ile 
            20                  25                  30          
Asn Asp Tyr Asn Lys Thr Ile Pro Arg Ile Ser Glu Asp Val Val Asp 
        35                  40                  45              
Val Ser Leu Gly Leu Gly Thr Tyr Tyr Val Leu Asn Arg Val Tyr Leu 
    50                  55                  60                  
Asn Thr Thr Leu Leu Phe Thr Gly Tyr Phe Pro Lys Ser Gly Ala Asn 
65                  70                  75                  80  
Phe Arg Asp Leu Ala Leu Lys Gly Ser Ile Tyr Leu Ser Thr Leu Trp 
                85                  90                  95      
Tyr Lys Pro Pro Phe Leu Ser Asp Phe Asn Asn Gly Ile Phe Ser Lys 
            100                 105                 110         
Val Lys Asn Thr Lys Leu Tyr Val Asn Asn Thr Leu Tyr Ser Glu Phe 
        115                 120                 125             
Ser Thr Ile Val Ile Gly Ser Val Phe Val Asn Thr Ser Tyr Thr Ile 
    130                 135                 140                 
Val Val Gln Pro His Asn Gly Ile Leu Glu Ile Thr Ala Cys Gln Tyr 
145                 150                 155                 160 
Thr Met Cys Glu Tyr Pro His Thr Val Cys Lys Ser Lys Gly Ser Ile 
                165                 170                 175     
Arg Asn Glu Ser Trp His Ile Asp Ser Ser Glu Pro Leu Cys Leu Phe 
            180                 185                 190         
Lys Lys Asn Phe Thr Tyr Asn Val Ser Ala Asp Trp Leu Tyr Phe His 
        195                 200                 205             
Phe Tyr Gln Glu Arg Gly Val Phe Tyr Ala Tyr Tyr Ala Asp Val Gly 
    210                 215                 220                 
Met Pro Thr Thr Phe Leu Phe Ser Leu Tyr Leu Gly Thr Ile Leu Ser 
225                 230                 235                 240 
His Tyr Tyr Val Met Pro Leu Thr Cys Asn Ala Ile Ser Ser Asn Thr 
                245                 250                 255     
Asp Asn Glu Thr Leu Glu Tyr Trp Val Thr Pro Leu Ser Arg Arg Gln 
            260                 265                 270         
Tyr Leu Leu Asn Phe Asp Glu His Gly Val Ile Thr Asn Ala Val Asp 
        275                 280                 285             
Cys Ser Ser Ser Phe Leu Ser Glu Ile Gln Cys Lys Thr Gln Ser Phe 
    290                 295                 300                 
Ala Pro Asn Thr Gly Val Tyr Asp Leu Ser Gly Phe Thr Val Lys Pro 
305                 310                 315                 320 
Val Ala Thr Val Tyr Arg Arg Ile Pro Asn Leu Pro Asp Cys Asp Ile 
                325                 330                 335     
Asp Asn Trp Leu Asn Asn Val Ser Val Pro Ser Pro Leu Asn Trp Glu 
            340                 345                 350         
Arg Arg Ile Phe Ser Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg 
        355                 360                 365             
Leu Val His Val Asp Ser Phe Ser Cys Asn Asn Leu Asp Lys Ser Lys 
    370                 375                 380                 
Ile Phe Gly Ser Cys Phe Asn Ser Ile Thr Val Asp Lys Phe Ala Ile 
385                 390                 395                 400 
Pro Asn Arg Arg Arg Asp Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu 
                405                 410                 415     
Gln Ser Ser Asn Tyr Lys Ile Asp Ile Ser Ser Ser Ser Cys Gln Leu 
            420                 425                 430         
Tyr Tyr Ser Leu Pro Leu Val Asn Val Thr Ile Asn Asn Phe Asn Pro 
        435                 440                 445             
Ser Ser Trp Asn Arg Arg Tyr Gly Phe Gly Ser Phe Asn Leu Ser Ser 
    450                 455                 460                 
Tyr Asp Val Val Tyr Ser Asp His Cys Phe Ser Val Asn Ser Asp Phe 
465                 470                 475                 480 
Cys Pro Cys Ala Asp Pro Ser Val Val Asn Ser Cys Ala Lys Ser Lys 
                485                 490                 495     
Pro Pro Ser Ala Ile Cys Pro Ala Gly Thr Lys Tyr Arg His Cys Asp 
            500                 505                 510         
Leu Asp Thr Thr Leu Tyr Val Lys Asn Trp Cys Arg Cys Ser Cys Leu 
        515                 520                 525             
Pro Asp Pro Ile Ser Thr Tyr Ser Pro Asn Thr Cys Pro Gln Lys Lys 
    530                 535                 540                 
Val Val Val Gly Ile Gly Glu His Cys Pro Gly Leu Gly Ile Asn Glu 
545                 550                 555                 560 
Glu Lys Cys Gly Thr Gln Leu Asn His Ser Ser Cys Phe Cys Ser Pro 
                565                 570                 575     
Asp Ala Phe Leu Gly Trp Ser Phe Asp Ser Cys Ile Ser Asn Asn Arg 
            580                 585                 590         
Cys Asn Ile Phe Ser Asn Phe Ile Phe Asn Gly Ile Asn Ser Gly Thr 
        595                 600                 605             
Thr Cys Ser Asn Asp Leu Leu Tyr Ser Asn Thr Glu Ile Ser Thr Gly 
    610                 615                 620                 
Val Cys Val Asn Tyr Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe 
625                 630                 635                 640 
Lys Glu Val Ser Ala Ala Tyr Tyr Asn Asn Trp Gln Asn Leu Leu Tyr 
                645                 650                 655     
Asp Ser Asn Gly Asn Ile Ile Gly Phe Lys Asp Phe Leu Thr Asn Lys 
            660                 665                 670         
Thr Tyr Thr Ile Leu Pro Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe 
        675                 680                 685             
Tyr Gln Asn Ser Ser Ser Pro Ala Leu Leu Tyr Arg Asn Leu Lys Cys 
    690                 695                 700                 
Ser Tyr Val Leu Asn Asn Ile Ser Phe Ile Ser Gln Pro Phe Tyr Phe 
705                 710                 715                 720 
Asp Ser Tyr Leu Gly Cys Val Leu Asn Ala Val Asn Leu Thr Ser Tyr 
                725                 730                 735     
Ser Val Ser Ser Cys Asp Leu Arg Met Gly Ser Gly Phe Cys Ile Asp 
            740                 745                 750         
Tyr Ala Leu Pro Ser Ser Gly Gly Ser Gly Ser Gly Ile Ser Ser Pro 
        755                 760                 765             
Tyr Arg Phe Val Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp 
    770                 775                 780                 
Ser Val Glu Thr Val Gly Gly Leu Phe Glu Ile Gln Ile Pro Thr Asn 
785                 790                 795                 800 
Phe Thr Ile Ala Gly His Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys 
                805                 810                 815     
Val Thr Ile Asp Cys Ser Ala Phe Val Cys Ser Asn Tyr Ala Ala Cys 
            820                 825                 830         
His Asp Leu Leu Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser 
        835                 840                 845             
Ile Leu Asn Glu Val Asn Asp Leu Leu Asp Ile Thr Gln Leu Gln Val 
    850                 855                 860                 
Ala Asn Ala Leu Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr 
865                 870                 875                 880 
Asn Leu His Ser Asp Val Asp Asn Ile Asp Phe Lys Ser Leu Leu Gly 
                885                 890                 895     
Cys Leu Gly Ser Gln Cys Gly Ser Ser Ser Arg Ser Leu Leu Glu Asp 
            900                 905                 910         
Leu Leu Phe Asn Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala 
        915                 920                 925             
Tyr Asn Asn Cys Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val 
    930                 935                 940                 
Gln Ser Phe Asn Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Thr 
945                 950                 955                 960 
Gln Ile Ser Gly Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro 
                965                 970                 975     
Pro Trp Ser Ala Ala Ala Gly Val Pro Phe Ser Leu Asn Val Gln Tyr 
            980                 985                 990         
Arg Ile Asn Gly Leu Gly Val Thr Met Asp Val Leu Asn Lys Asn Gln 
        995                 1000                1005            
Lys Leu Ile Ala Asn Ala Phe Asn Lys Ala Leu Leu Ser Ile Gln Asn 
    1010                1015                1020                
Gly Phe Thr Ala Thr Asn Ser Ala Leu Ala Lys Ile Gln Ser Val Val 
1025                1030                1035                1040
Asn Ala Asn Ala Gln Ala Leu Asn Ser Leu Leu Gln Gln Leu Phe Asn 
                1045                1050                1055    
Lys Phe Gly Ala Ile Ser Ser Ser Leu Gln Glu Ile Leu Ser Arg Leu 
            1060                1065                1070        
Asp Pro Pro Glu Ala Gln Val Gln Ile Asp Arg Leu Ile Asn Gly Arg 
        1075                1080                1085            
Leu Thr Ala Leu Asn Ala Tyr Val Ser Gln Gln Leu Ser Asp Ile Thr 
    1090                1095                1100                
Leu Ile Lys Ala Gly Ala Ser Arg Ala Ile Glu Lys Val Asn Glu Cys 
1105                1110                1115                1120
Val Lys Ser Gln Ser Pro Arg Ile Asn Phe Cys Gly Asn Gly Asn His 
                1125                1130                1135    
Ile Leu Ser Leu Val Gln Asn Ala Pro Tyr Gly Leu Leu Phe Ile His 
            1140                1145                1150        
Phe Ser Tyr Lys Pro Thr Ser Phe Lys Thr Val Leu Val Ser Pro Gly 
        1155                1160                1165            
Leu Cys Leu Ser Gly Asp Arg Gly Ile Ala Pro Lys Gln Gly Tyr Phe 
    1170                1175                1180                
Ile Lys Gln Asn Asp Ser Trp Met Phe Thr Gly Ser Ser Tyr Tyr Tyr 
1185                1190                1195                1200
Pro Glu Pro Ile Ser Asp Lys Asn Val Val Phe Met Asn Ser Cys Ser 
                1205                1210                1215    
Val Asn Phe Thr Lys Ala Pro Phe Ile Tyr Leu Asn Asn Ser Ile Pro 
            1220                1225                1230        
Asn Leu Ser Asp Phe Glu Ala Glu Leu Ser Leu Trp Phe Lys Asn His 
        1235                1240                1245            
Thr Ser Ile Ala Pro Asn Leu Thr Phe Asn Ser His Ile Asn Ala Thr 
    1250                1255                1260                
Phe Leu Asp Leu Tyr Tyr Glu Met Asn Val Ile Gln Glu Ser Ile Lys 
1265                1270                1275                1280
Ser Leu Asn Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln 
                1285                1290                1295    
Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            1300                1305                1310        
Gly Ser Leu Val Pro Arg Gly Ser His His His His His His His His 
        1315                1320                1325            



<210> 117
<211> 1356
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (CoV-MERS Spike ectodomain)

<400> 117
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys 
            20                  25                  30          
Ile Glu Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg 
        35                  40                  45              
Pro Ile Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg 
    50                  55                  60                  
Thr Tyr Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln 
65                  70                  75                  80  
Gly Asp His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly 
                85                  90                  95      
Thr Thr Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys 
            100                 105                 110         
Gln Phe Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser 
        115                 120                 125             
Thr Gly Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys 
    130                 135                 140                 
Ile Tyr Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp 
145                 150                 155                 160 
Gly Lys Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp 
                165                 170                 175     
Gly Cys Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg 
            180                 185                 190         
Ser Gly Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr 
        195                 200                 205             
Tyr His Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn 
    210                 215                 220                 
Ala Ser Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr 
225                 230                 235                 240 
Phe Met Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe 
                245                 250                 255     
Gly Ile Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr 
            260                 265                 270         
Val Asp Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val 
        275                 280                 285             
Tyr Asp Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser 
    290                 295                 300                 
Ile Gln Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu 
305                 310                 315                 320 
Gln Pro Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg 
                325                 330                 335     
Arg Ala Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser 
            340                 345                 350         
Tyr Glu Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe 
        355                 360                 365             
Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
    370                 375                 380                 
Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
385                 390                 395                 400 
Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
                405                 410                 415     
Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
            420                 425                 430         
Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
        435                 440                 445             
Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
    450                 455                 460                 
Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
465                 470                 475                 480 
Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
                485                 490                 495     
Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
            500                 505                 510         
Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
        515                 520                 525             
Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
    530                 535                 540                 
Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
545                 550                 555                 560 
Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
                565                 570                 575     
Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
            580                 585                 590         
Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr 
        595                 600                 605             
Ser Leu Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala 
    610                 615                 620                 
Val Gly Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu 
625                 630                 635                 640 
Val Gly Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys 
                645                 650                 655     
Val Ser Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His 
            660                 665                 670         
Ala Thr Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met 
        675                 680                 685             
Ser Gln Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser 
    690                 695                 700                 
Thr Tyr Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val 
705                 710                 715                 720 
Asn Ser Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser 
                725                 730                 735     
Leu Cys Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Ala Ser Val 
            740                 745                 750         
Gly Ser Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His 
        755                 760                 765             
Pro Ile Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile 
    770                 775                 780                 
Pro Thr Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr 
785                 790                 795                 800 
Ile Gln Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe 
                805                 810                 815     
Gln Lys Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys 
            820                 825                 830         
Ile Asn Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val 
        835                 840                 845             
Arg Asn Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile 
    850                 855                 860                 
Pro Gly Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser 
865                 870                 875                 880 
Ile Ser Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu 
                885                 890                 895     
Phe Asp Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp 
            900                 905                 910         
Asp Cys Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala 
        915                 920                 925             
Gln Tyr Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn 
    930                 935                 940                 
Met Glu Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val 
945                 950                 955                 960 
Gly Trp Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln 
                965                 970                 975     
Ser Ile Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu 
            980                 985                 990         
Ser Glu Asn Gln Lys Leu Ile Ala Asn Lys Phe Asn Gln Ala Leu Gly 
        995                 1000                1005            
Ala Met Gln Thr Gly Phe Thr Thr Thr Asn Glu Ala Phe Gln Lys Val 
    1010                1015                1020                
Gln Asp Ala Val Asn Asn Asn Ala Gln Ala Leu Ser Lys Leu Ala Ser 
1025                1030                1035                1040
Glu Leu Ser Asn Thr Phe Gly Ala Ile Ser Ala Ser Ile Gly Asp Ile 
                1045                1050                1055    
Ile Gln Arg Leu Asp Pro Pro Glu Gln Asp Ala Gln Ile Asp Arg Leu 
            1060                1065                1070        
Ile Asn Gly Arg Leu Thr Thr Leu Asn Ala Phe Val Ala Gln Gln Leu 
        1075                1080                1085            
Val Arg Ser Glu Ser Ala Ala Leu Ser Ala Gln Leu Ala Lys Asp Lys 
    1090                1095                1100                
Val Asn Glu Cys Val Lys Ala Gln Ser Lys Arg Ser Gly Phe Cys Gly 
1105                1110                1115                1120
Gln Gly Thr His Ile Val Ser Phe Val Val Asn Ala Pro Asn Gly Leu 
                1125                1130                1135    
Tyr Phe Met His Val Gly Tyr Tyr Pro Ser Asn His Ile Glu Val Val 
            1140                1145                1150        
Ser Ala Tyr Gly Leu Cys Asp Ala Ala Asn Pro Thr Asn Cys Ile Ala 
        1155                1160                1165            
Pro Val Asn Gly Tyr Phe Ile Lys Thr Asn Asn Thr Arg Ile Val Asp 
    1170                1175                1180                
Glu Trp Ser Tyr Thr Gly Ser Ser Phe Tyr Ala Pro Glu Pro Ile Thr 
1185                1190                1195                1200
Ser Leu Asn Thr Lys Tyr Val Ala Pro Gln Val Thr Tyr Gln Asn Ile 
                1205                1210                1215    
Ser Thr Asn Leu Pro Pro Pro Leu Leu Gly Asn Ser Thr Gly Ile Asp 
            1220                1225                1230        
Phe Gln Asp Glu Leu Asp Glu Phe Phe Lys Asn Val Ser Thr Ser Ile 
        1235                1240                1245            
Pro Asn Phe Gly Ser Leu Thr Gln Ile Asn Thr Thr Leu Leu Asp Leu 
    1250                1255                1260                
Thr Tyr Glu Met Leu Ser Leu Gln Gln Val Val Lys Ala Leu Asn Glu 
1265                1270                1275                1280
Ser Tyr Ile Asp Leu Lys Glu Leu Gly Asn Tyr Thr Tyr Tyr Asn Lys 
                1285                1290                1295    
Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
            1300                1305                1310        
Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Leu 
        1315                1320                1325            
Val Pro Arg Gly Ser His His His His His His His His Gly Leu Asn 
    1330                1335                1340                
Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1345                1350                1355    

<210> 118
<211> 1245
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (SARS-CoV-1 Spike ectodomain)

<400> 118
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Ser Asp Leu Asp Arg Cys Thr Thr Phe Asp Asp Val 
            20                  25                  30          
Gln Ala Pro Asn Tyr Thr Gln His Thr Ser Ser Met Arg Gly Val Tyr 
        35                  40                  45              
Tyr Pro Asp Glu Ile Phe Arg Ser Asp Thr Leu Tyr Leu Thr Gln Asp 
    50                  55                  60                  
Leu Phe Leu Pro Phe Tyr Ser Asn Val Thr Gly Phe His Thr Ile Asn 
65                  70                  75                  80  
His Thr Phe Asp Asn Pro Val Ile Pro Phe Lys Asp Gly Ile Tyr Phe 
                85                  90                  95      
Ala Ala Thr Glu Lys Ser Asn Val Val Arg Gly Trp Val Phe Gly Ser 
            100                 105                 110         
Thr Met Asn Asn Lys Ser Gln Ser Val Ile Ile Ile Asn Asn Ser Thr 
        115                 120                 125             
Asn Val Val Ile Arg Ala Cys Asn Phe Glu Leu Cys Asp Asn Pro Phe 
    130                 135                 140                 
Phe Ala Val Ser Lys Pro Met Gly Thr Gln Thr His Thr Met Ile Phe 
145                 150                 155                 160 
Asp Asn Ala Phe Asn Cys Thr Phe Glu Tyr Ile Ser Asp Ala Phe Ser 
                165                 170                 175     
Leu Asp Val Ser Glu Lys Ser Gly Asn Phe Lys His Leu Arg Glu Phe 
            180                 185                 190         
Val Phe Lys Asn Lys Asp Gly Phe Leu Tyr Val Tyr Lys Gly Tyr Gln 
        195                 200                 205             
Pro Ile Asp Val Val Arg Asp Leu Pro Ser Gly Phe Asn Thr Leu Lys 
    210                 215                 220                 
Pro Ile Phe Lys Leu Pro Leu Gly Ile Asn Ile Thr Asn Phe Arg Ala 
225                 230                 235                 240 
Ile Leu Thr Ala Phe Ser Pro Ala Gln Asp Thr Trp Gly Thr Ser Ala 
                245                 250                 255     
Ala Ala Tyr Phe Val Gly Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys 
            260                 265                 270         
Tyr Asp Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn 
        275                 280                 285             
Pro Leu Ala Glu Leu Lys Cys Ser Val Lys Ser Phe Glu Ile Asp Lys 
    290                 295                 300                 
Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Val Pro Ser Gly Asp Val 
305                 310                 315                 320 
Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
                325                 330                 335     
Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile 
            340                 345                 350         
Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe 
        355                 360                 365             
Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu 
    370                 375                 380                 
Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp 
385                 390                 395                 400 
Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn 
                405                 410                 415     
Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr 
            420                 425                 430         
Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg 
        435                 440                 445             
Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn 
    450                 455                 460                 
Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn 
465                 470                 475                 480 
Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile 
                485                 490                 495     
Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn 
            500                 505                 510         
Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys 
        515                 520                 525             
Asn Gln Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
    530                 535                 540                 
Leu Thr Pro Ser Ser Lys Arg Phe Gln Pro Phe Gln Gln Phe Gly Arg 
545                 550                 555                 560 
Asp Val Ser Asp Phe Thr Asp Ser Val Arg Asp Pro Lys Thr Ser Glu 
                565                 570                 575     
Ile Leu Asp Ile Ser Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
            580                 585                 590         
Pro Gly Thr Asn Ala Ser Ser Glu Val Ala Val Leu Tyr Gln Asp Val 
        595                 600                 605             
Asn Cys Thr Asp Val Ser Thr Ala Ile His Ala Asp Gln Leu Thr Pro 
    610                 615                 620                 
Ala Trp Arg Ile Tyr Ser Thr Gly Asn Asn Val Phe Gln Thr Gln Ala 
625                 630                 635                 640 
Gly Cys Leu Ile Gly Ala Glu His Val Asp Thr Ser Tyr Glu Cys Asp 
                645                 650                 655     
Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr His Thr Val Ser Leu 
            660                 665                 670         
Leu Arg Ser Thr Ser Gln Lys Ser Ile Val Ala Tyr Thr Met Ser Leu 
        675                 680                 685             
Gly Ala Asp Ser Ser Ile Ala Tyr Ser Asn Asn Thr Ile Ala Ile Pro 
    690                 695                 700                 
Thr Asn Phe Ser Ile Ser Ile Thr Thr Glu Val Met Pro Val Ser Met 
705                 710                 715                 720 
Ala Lys Thr Ser Val Asp Cys Asn Met Tyr Ile Cys Gly Asp Ser Thr 
                725                 730                 735     
Glu Cys Ala Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
            740                 745                 750         
Asn Arg Ala Leu Ser Gly Ile Ala Ala Glu Gln Asp Arg Asn Thr Arg 
        755                 760                 765             
Glu Val Phe Ala Gln Val Lys Gln Met Tyr Lys Thr Pro Thr Leu Lys 
    770                 775                 780                 
Tyr Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Leu Lys 
785                 790                 795                 800 
Pro Thr Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
                805                 810                 815     
Leu Ala Asp Ala Gly Phe Met Lys Gln Tyr Gly Glu Cys Leu Gly Asp 
            820                 825                 830         
Ile Asn Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
        835                 840                 845             
Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile Ala Ala Tyr Thr Ala 
    850                 855                 860                 
Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly 
865                 870                 875                 880 
Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
                885                 890                 895     
Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Gln Ile 
            900                 905                 910         
Ala Asn Gln Phe Asn Lys Ala Ile Ser Gln Ile Gln Glu Ser Leu Thr 
        915                 920                 925             
Thr Thr Ser Thr Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
    930                 935                 940                 
Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
945                 950                 955                 960 
Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
                965                 970                 975     
Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser 
            980                 985                 990         
Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg 
        995                 1000                1005            
Ala Ser Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly 
    1010                1015                1020                
Gln Ser Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser 
1025                1030                1035                1040
Phe Pro Gln Ala Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr 
                1045                1050                1055    
Val Pro Ser Gln Glu Arg Asn Phe Thr Thr Ala Pro Ala Ile Cys His 
            1060                1065                1070        
Glu Gly Lys Ala Tyr Phe Pro Arg Glu Gly Val Phe Val Phe Asn Gly 
        1075                1080                1085            
Thr Ser Trp Phe Ile Thr Gln Arg Asn Phe Phe Ser Pro Gln Ile Ile 
    1090                1095                1100                
Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly 
1105                1110                1115                1120
Ile Ile Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser 
                1125                1130                1135    
Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp 
            1140                1145                1150        
Val Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile 
        1155                1160                1165            
Gln Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu 
    1170                1175                1180                
Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys 
1185                1190                1195                1200
Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
                1205                1210                1215    
Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Leu 
            1220                1225                1230        
Val Pro Arg Gly Ser His His His His His His His His 
        1235                1240                1245

<210> 119
<211> 1165
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (CoV-229E Spike ectodomain)

<400> 119
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Ala Gly Cys Gln Thr Thr Asn Gly Leu Asn Thr Ser 
            20                  25                  30          
Tyr Ser Val Cys Asn Gly Cys Val Gly Tyr Ser Glu Asn Val Phe Ala 
        35                  40                  45              
Val Glu Ser Gly Gly Tyr Ile Pro Ser Asp Phe Ala Phe Asn Asn Trp 
    50                  55                  60                  
Phe Leu Leu Thr Asn Thr Ser Ser Val Val Asp Gly Val Val Arg Ser 
65                  70                  75                  80  
Phe Gln Pro Leu Leu Leu Asn Cys Leu Trp Ser Val Ser Gly Leu Arg 
                85                  90                  95      
Phe Thr Thr Gly Phe Val Tyr Phe Asn Gly Thr Gly Arg Gly Asp Cys 
            100                 105                 110         
Lys Gly Phe Ser Ser Asp Val Leu Ser Asp Val Ile Arg Tyr Asn Leu 
        115                 120                 125             
Asn Phe Glu Glu Asn Leu Arg Arg Gly Thr Ile Leu Phe Lys Thr Ser 
    130                 135                 140                 
Tyr Gly Val Val Val Phe Tyr Cys Thr Asn Asn Thr Leu Val Ser Gly 
145                 150                 155                 160 
Asp Ala His Ile Pro Phe Gly Thr Val Leu Gly Asn Phe Tyr Cys Phe 
                165                 170                 175     
Val Asn Thr Thr Ile Gly Thr Glu Thr Thr Ser Ala Phe Val Gly Ala 
            180                 185                 190         
Leu Pro Lys Thr Val Arg Glu Phe Val Ile Ser Arg Thr Gly His Phe 
        195                 200                 205             
Tyr Ile Asn Gly Tyr Arg Tyr Phe Thr Leu Gly Asn Val Glu Ala Val 
    210                 215                 220                 
Asn Phe Asn Val Thr Thr Ala Glu Thr Thr Asp Phe Phe Thr Val Ala 
225                 230                 235                 240 
Leu Ala Ser Tyr Ala Asp Val Leu Val Asn Val Ser Gln Thr Ser Ile 
                245                 250                 255     
Ala Asn Ile Ile Tyr Cys Asn Ser Val Ile Asn Arg Leu Arg Cys Asp 
            260                 265                 270         
Gln Leu Ser Phe Tyr Val Pro Asp Gly Phe Tyr Ser Thr Ser Pro Ile 
        275                 280                 285             
Gln Ser Val Glu Leu Pro Val Ser Ile Val Ser Leu Pro Val Tyr His 
    290                 295                 300                 
Lys His Met Phe Ile Val Leu Tyr Val Asp Phe Lys Pro Gln Ser Gly 
305                 310                 315                 320 
Gly Gly Lys Cys Phe Asn Cys Tyr Pro Ala Gly Val Asn Ile Thr Leu 
                325                 330                 335     
Ala Asn Phe Asn Glu Thr Lys Gly Pro Leu Cys Val Asp Thr Ser His 
            340                 345                 350         
Phe Thr Thr Lys Tyr Val Ala Val Tyr Ala Asn Val Gly Arg Trp Ser 
        355                 360                 365             
Ala Ser Ile Asn Thr Gly Asn Cys Pro Phe Ser Phe Gly Lys Val Asn 
    370                 375                 380                 
Asn Phe Val Lys Phe Gly Ser Val Cys Phe Ser Leu Lys Asp Ile Pro 
385                 390                 395                 400 
Gly Gly Cys Ala Met Pro Ile Val Ala Asn Trp Ala Tyr Ser Lys Tyr 
                405                 410                 415     
Tyr Thr Ile Gly Thr Leu Tyr Val Ser Trp Ser Asp Gly Asp Gly Ile 
            420                 425                 430         
Thr Gly Val Pro Gln Pro Val Glu Gly Val Ser Ser Phe Met Asn Val 
        435                 440                 445             
Thr Leu Asp Lys Cys Thr Lys Tyr Asn Ile Tyr Asp Val Ser Gly Val 
    450                 455                 460                 
Gly Val Ile Arg Val Ser Asn Asp Thr Phe Leu Asn Gly Ile Thr Tyr 
465                 470                 475                 480 
Thr Ser Thr Ser Gly Asn Leu Leu Gly Phe Lys Asp Val Thr Lys Gly 
                485                 490                 495     
Thr Ile Tyr Ser Ile Thr Pro Cys Asn Pro Pro Asp Gln Leu Val Val 
            500                 505                 510         
Tyr Gln Gln Ala Val Val Gly Ala Met Leu Ser Glu Asn Phe Thr Ser 
        515                 520                 525             
Tyr Gly Phe Ser Asn Val Val Glu Leu Pro Lys Phe Phe Tyr Ala Ser 
    530                 535                 540                 
Asn Gly Thr Tyr Asn Cys Thr Asp Ala Val Leu Thr Tyr Ser Ser Phe 
545                 550                 555                 560 
Gly Val Cys Ala Asp Gly Ser Ile Ile Ala Val Gln Pro Arg Asn Val 
                565                 570                 575     
Ser Tyr Asp Ser Val Ser Ala Ile Val Thr Ala Asn Leu Ser Ile Pro 
            580                 585                 590         
Ser Asn Trp Thr Ile Ser Val Gln Val Glu Tyr Leu Gln Ile Thr Ser 
        595                 600                 605             
Thr Pro Ile Val Val Asp Cys Ser Thr Tyr Val Cys Asn Gly Asn Val 
    610                 615                 620                 
Arg Cys Val Glu Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr Ile 
625                 630                 635                 640 
Glu Asp Ala Leu Arg Asn Ser Ala Arg Leu Glu Ser Ala Asp Val Ser 
                645                 650                 655     
Glu Met Leu Thr Phe Asp Lys Lys Ala Phe Thr Leu Ala Asn Val Ser 
            660                 665                 670         
Ser Phe Gly Asp Tyr Asn Leu Ser Ser Val Ile Pro Ser Leu Pro Thr 
        675                 680                 685             
Ser Gly Ser Arg Val Ala Gly Arg Ser Ala Ile Glu Asp Ile Leu Phe 
    690                 695                 700                 
Ser Lys Ile Val Thr Ser Gly Leu Gly Thr Val Asp Ala Asp Tyr Lys 
705                 710                 715                 720 
Asn Cys Thr Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln Tyr 
                725                 730                 735     
Tyr Asn Gly Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg Met 
            740                 745                 750         
Ala Met Tyr Thr Gly Ser Leu Ile Gly Gly Ile Ala Leu Gly Gly Leu 
        755                 760                 765             
Thr Ser Ala Val Ser Ile Pro Phe Ser Leu Ala Ile Gln Ala Arg Leu 
    770                 775                 780                 
Asn Tyr Val Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys Ile 
785                 790                 795                 800 
Leu Ala Ala Ser Phe Asn Lys Ala Met Thr Asn Ile Val Asp Ala Phe 
                805                 810                 815     
Thr Gly Val Asn Asp Ala Ile Thr Gln Thr Ser Gln Ala Leu Gln Thr 
            820                 825                 830         
Val Ala Thr Ala Leu Asn Lys Ile Gln Asp Val Val Asn Gln Gln Gly 
        835                 840                 845             
Asn Ser Leu Asn His Leu Thr Ser Gln Leu Arg Gln Asn Phe Gln Ala 
    850                 855                 860                 
Ile Ser Ser Ser Ile Gln Ala Ile Tyr Asp Arg Leu Asp Pro Pro Gln 
865                 870                 875                 880 
Ala Asp Gln Gln Val Asp Arg Leu Ile Thr Gly Arg Leu Ala Ala Leu 
                885                 890                 895     
Asn Val Phe Val Ser His Thr Leu Thr Lys Tyr Thr Glu Val Arg Ala 
            900                 905                 910         
Ser Arg Gln Leu Ala Gln Gln Lys Val Asn Glu Cys Val Lys Ser Gln 
        915                 920                 925             
Ser Lys Arg Tyr Gly Phe Cys Gly Asn Gly Thr His Ile Phe Ser Ile 
    930                 935                 940                 
Val Asn Ala Ala Pro Glu Gly Leu Val Phe Leu His Thr Val Leu Leu 
945                 950                 955                 960 
Pro Thr Gln Tyr Lys Asp Val Glu Ala Trp Ser Gly Leu Cys Val Asp 
                965                 970                 975     
Gly Thr Asn Gly Tyr Val Leu Arg Gln Pro Asn Leu Ala Leu Tyr Lys 
            980                 985                 990         
Glu Gly Asn Tyr Tyr Arg Ile Thr Ser Arg Ile Met Phe Glu Pro Arg 
        995                 1000                1005            
Ile Pro Thr Met Ala Asp Phe Val Gln Ile Glu Asn Cys Asn Val Thr 
    1010                1015                1020                
Phe Val Asn Ile Ser Arg Ser Glu Leu Gln Thr Ile Val Pro Glu Tyr 
1025                1030                1035                1040
Ile Asp Val Asn Lys Thr Leu Gln Glu Leu Ser Tyr Lys Leu Pro Asn 
                1045                1050                1055    
Tyr Thr Val Pro Asp Leu Val Val Glu Gln Tyr Asn Gln Thr Ile Leu 
            1060                1065                1070        
Asn Leu Thr Ser Glu Ile Ser Thr Leu Glu Asn Lys Ser Ala Glu Leu 
        1075                1080                1085            
Asn Tyr Thr Val Gln Lys Leu Gln Thr Leu Ile Asp Asn Ile Asn Ser 
    1090                1095                1100                
Thr Leu Val Asp Leu Lys Trp Leu Asn Arg Val Glu Thr Tyr Ile Lys 
1105                1110                1115                1120
Ser Gly Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
                1125                1130                1135    
Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Leu 
            1140                1145                1150        
Val Pro Arg Gly Ser His His His His His His His His 
        1155                1160                1165

<210> 120
<211> 1345
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic polypeptide (CoV-NL63 Spike ectodomain)

<400> 120
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Phe Phe Thr Cys Asn Ser Asn Ala Asn Leu Ser Met 
            20                  25                  30          
Leu Gln Leu Gly Val Pro Asp Asn Ser Ser Thr Ile Val Thr Gly Leu 
        35                  40                  45              
Leu Pro Thr His Trp Phe Cys Ala Asn Gln Ser Thr Ser Val Tyr Ser 
    50                  55                  60                  
Ala Asn Gly Phe Phe Tyr Ile Asp Val Gly Asn His Arg Ser Ala Phe 
65                  70                  75                  80  
Ala Leu His Thr Gly Tyr Tyr Asp Ala Asn Gln Tyr Tyr Ile Tyr Val 
                85                  90                  95      
Thr Asn Glu Ile Gly Leu Asn Ala Ser Val Thr Leu Lys Ile Cys Lys 
            100                 105                 110         
Phe Ser Arg Asn Thr Thr Phe Asp Phe Leu Ser Asn Ala Ser Ser Ser 
        115                 120                 125             
Phe Asp Cys Ile Val Asn Leu Leu Phe Thr Glu Gln Leu Gly Ala Pro 
    130                 135                 140                 
Leu Gly Ile Thr Ile Ser Gly Glu Thr Val Arg Leu His Leu Tyr Asn 
145                 150                 155                 160 
Val Thr Arg Thr Phe Tyr Val Pro Ala Ala Tyr Lys Leu Thr Lys Leu 
                165                 170                 175     
Ser Val Lys Cys Tyr Phe Asn Tyr Ser Cys Val Phe Ser Val Val Asn 
            180                 185                 190         
Ala Thr Val Thr Val Asn Val Thr Thr His Asn Gly Arg Val Val Asn 
        195                 200                 205             
Tyr Thr Val Cys Asp Asp Cys Asn Gly Tyr Thr Asp Asn Ile Phe Ser 
    210                 215                 220                 
Val Gln Gln Asp Gly Arg Ile Pro Asn Gly Phe Pro Phe Asn Asn Trp 
225                 230                 235                 240 
Phe Leu Leu Thr Asn Gly Ser Thr Leu Val Asp Gly Val Ser Arg Leu 
                245                 250                 255     
Tyr Gln Pro Leu Arg Leu Thr Cys Leu Trp Pro Val Pro Gly Leu Lys 
            260                 265                 270         
Ser Ser Thr Gly Phe Val Tyr Phe Asn Ala Thr Gly Ser Asp Val Asn 
        275                 280                 285             
Cys Asn Gly Tyr Gln His Asn Ser Val Val Asp Val Met Arg Tyr Asn 
    290                 295                 300                 
Leu Asn Phe Ser Ala Asn Ser Leu Asp Asn Leu Lys Ser Gly Val Ile 
305                 310                 315                 320 
Val Phe Lys Thr Leu Gln Tyr Asp Val Leu Phe Tyr Cys Ser Asn Ser 
                325                 330                 335     
Ser Ser Gly Val Leu Asp Thr Thr Ile Pro Phe Gly Pro Ser Ser Gln 
            340                 345                 350         
Pro Tyr Tyr Cys Phe Ile Asn Ser Thr Ile Asn Thr Thr His Val Ser 
        355                 360                 365             
Thr Phe Val Gly Ile Leu Pro Pro Thr Val Arg Glu Ile Val Val Ala 
    370                 375                 380                 
Arg Thr Gly Gln Phe Tyr Ile Asn Gly Phe Lys Tyr Phe Asp Leu Gly 
385                 390                 395                 400 
Phe Ile Glu Ala Val Asn Phe Asn Val Thr Thr Ala Ser Ala Thr Asp 
                405                 410                 415     
Phe Trp Thr Val Ala Phe Ala Thr Phe Val Asp Val Leu Val Asn Val 
            420                 425                 430         
Ser Ala Thr Asn Ile Gln Asn Leu Leu Tyr Cys Asp Ser Pro Phe Glu 
        435                 440                 445             
Lys Leu Gln Cys Glu His Leu Gln Phe Gly Leu Gln Asp Gly Phe Tyr 
    450                 455                 460                 
Ser Ala Asn Phe Leu Asp Asp Asn Val Leu Pro Glu Thr Tyr Val Ala 
465                 470                 475                 480 
Leu Pro Ile Tyr Tyr Gln His Thr Asp Ile Asn Phe Thr Ala Thr Ala 
                485                 490                 495     
Ser Phe Gly Gly Ser Cys Tyr Val Cys Lys Pro His Gln Val Asn Ile 
            500                 505                 510         
Ser Leu Asn Gly Asn Thr Ser Val Cys Val Arg Thr Ser His Phe Ser 
        515                 520                 525             
Ile Arg Tyr Ile Tyr Asn Arg Val Lys Ser Gly Ser Pro Gly Asp Ser 
    530                 535                 540                 
Ser Trp His Ile Tyr Leu Lys Ser Gly Thr Cys Pro Phe Ser Phe Ser 
545                 550                 555                 560 
Lys Leu Asn Asn Phe Gln Lys Phe Lys Thr Ile Cys Phe Ser Thr Val 
                565                 570                 575     
Glu Val Pro Gly Ser Cys Asn Phe Pro Leu Glu Ala Thr Trp His Tyr 
            580                 585                 590         
Thr Ser Tyr Thr Ile Val Gly Ala Leu Tyr Val Thr Trp Ser Glu Gly 
        595                 600                 605             
Asn Ser Ile Thr Gly Val Pro Tyr Pro Val Ser Gly Ile Arg Glu Phe 
    610                 615                 620                 
Ser Asn Leu Val Leu Asn Asn Cys Thr Lys Tyr Asn Ile Tyr Asp Tyr 
625                 630                 635                 640 
Val Gly Thr Gly Ile Ile Arg Ser Ser Asn Gln Ser Leu Ala Gly Gly 
                645                 650                 655     
Ile Thr Tyr Val Ser Asn Ser Gly Asn Leu Leu Gly Phe Lys Asn Val 
            660                 665                 670         
Ser Thr Gly Asn Ile Phe Ile Val Thr Pro Cys Asn Gln Pro Asp Gln 
        675                 680                 685             
Val Ala Val Tyr Gln Gln Ser Ile Ile Gly Ala Met Thr Ala Val Asn 
    690                 695                 700                 
Glu Ser Arg Tyr Gly Leu Gln Asn Leu Leu Gln Leu Pro Asn Phe Tyr 
705                 710                 715                 720 
Tyr Val Ser Asn Gly Gly Asn Asn Cys Thr Thr Ala Val Met Thr Tyr 
                725                 730                 735     
Ser Asn Phe Gly Ile Cys Ala Asp Gly Ser Leu Ile Pro Val Arg Pro 
            740                 745                 750         
Arg Asn Ser Ser Asp Asn Gly Ile Ser Ala Ile Ile Thr Ala Asn Leu 
        755                 760                 765             
Ser Ile Pro Ser Asn Trp Thr Thr Ser Val Gln Val Glu Tyr Leu Gln 
    770                 775                 780                 
Ile Thr Ser Thr Pro Ile Val Val Asp Cys Ala Thr Tyr Val Cys Asn 
785                 790                 795                 800 
Gly Asn Pro Arg Cys Lys Asn Leu Leu Lys Gln Tyr Thr Ser Ala Cys 
                805                 810                 815     
Lys Thr Ile Glu Asp Ala Leu Arg Leu Ser Ala His Leu Glu Thr Asn 
            820                 825                 830         
Asp Val Ser Ser Met Leu Thr Phe Asp Ser Asn Ala Phe Ser Leu Ala 
        835                 840                 845             
Asn Val Thr Ser Phe Gly Asp Tyr Asn Leu Ser Ser Val Leu Pro Gln 
    850                 855                 860                 
Arg Asn Ile Arg Ser Ser Arg Ile Ala Gly Arg Ser Ala Leu Glu Asp 
865                 870                 875                 880 
Leu Leu Phe Ser Lys Val Val Thr Ser Gly Leu Gly Thr Val Asp Val 
                885                 890                 895     
Asp Tyr Lys Ser Cys Thr Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys 
            900                 905                 910         
Ala Gln Tyr Tyr Asn Gly Ile Met Val Leu Pro Gly Val Ala Asp Ala 
        915                 920                 925             
Glu Arg Met Ala Met Tyr Thr Gly Ser Leu Ile Gly Gly Met Val Leu 
    930                 935                 940                 
Gly Gly Leu Thr Ser Ala Ala Ala Ile Pro Phe Ser Leu Ala Leu Gln 
945                 950                 955                 960 
Ala Arg Leu Asn Tyr Val Ala Leu Gln Thr Asp Val Leu Gln Glu Asn 
                965                 970                 975     
Gln Lys Ile Leu Ala Ala Ser Phe Asn Lys Ala Ile Asn Asn Ile Val 
            980                 985                 990         
Ala Ser Phe Ser Ser Val Asn Asp Ala Ile Thr Gln Thr Ala Glu Ala 
        995                 1000                1005            
Ile His Thr Val Thr Ile Ala Leu Asn Lys Ile Gln Asp Val Val Asn 
    1010                1015                1020                
Gln Gln Gly Ser Ala Leu Asn His Leu Thr Ser Gln Leu Arg His Asn 
1025                1030                1035                1040
Phe Gln Ala Ile Ser Asn Ser Ile Gln Ala Ile Tyr Asp Arg Leu Asp 
                1045                1050                1055    
Ser Pro Pro Ala Asp Gln Gln Val Asp Arg Leu Ile Thr Gly Arg Leu 
            1060                1065                1070        
Ala Ala Leu Asn Ala Phe Val Ser Gln Val Leu Asn Lys Tyr Thr Glu 
        1075                1080                1085            
Val Arg Gly Ser Arg Arg Leu Ala Gln Gln Lys Ile Asn Glu Cys Val 
    1090                1095                1100                
Lys Ser Gln Ser Asn Arg Tyr Gly Phe Cys Gly Asn Gly Thr His Ile 
1105                1110                1115                1120
Phe Ser Ile Val Asn Ser Ala Pro Asp Gly Leu Leu Phe Leu His Thr 
                1125                1130                1135    
Val Leu Leu Pro Thr Asp Tyr Lys Asn Val Lys Ala Trp Ser Gly Ile 
            1140                1145                1150        
Cys Val Asp Gly Ile Tyr Gly Tyr Val Leu Arg Gln Pro Asn Leu Val 
        1155                1160                1165            
Leu Tyr Ser Asp Asn Gly Val Phe Arg Val Thr Ser Arg Val Met Phe 
    1170                1175                1180                
Gln Pro Arg Leu Pro Val Leu Ser Asp Phe Val Gln Ile Tyr Asn Cys 
1185                1190                1195                1200
Asn Val Thr Phe Val Asn Ile Ser Arg Val Glu Leu His Thr Val Ile 
                1205                1210                1215    
Pro Asp Tyr Val Asp Val Asn Lys Thr Leu Gln Glu Phe Ala Gln Asn 
            1220                1225                1230        
Leu Pro Lys Tyr Val Lys Pro Asn Phe Asp Leu Thr Pro Phe Asn Leu 
        1235                1240                1245            
Thr Tyr Leu Asn Leu Ser Ser Glu Leu Lys Gln Leu Glu Ala Lys Thr 
    1250                1255                1260                
Ala Ser Leu Phe Gln Thr Thr Val Glu Leu Gln Gly Leu Ile Asp Gln 
1265                1270                1275                1280
Ile Asn Ser Thr Tyr Val Asp Leu Lys Leu Leu Asn Arg Phe Glu Asn 
                1285                1290                1295    
Leu Ile Lys Arg Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Glu 
            1300                1305                1310        
Ser Lys Gln Lys Lys Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Ile 
        1315                1320                1325            
Lys Gly Ser Leu Val Pro Arg Gly Ser His His His His His His His 
    1330                1335                1340                
His 
1345

<210> 121
<211> 8
<212> PRT
<213> artificial sequence


<220> 
<223> synthetic peptide (StrepTag)

<400> 121
Trp Ser His Pro Gln Phe Glu Lys 
1               5               

<210> 122
<211> 263
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic polypeptide (SARS-CoV-2 kappa variant B.1.617.1/3 RBD
      domain)

<400> 122
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          
Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              
Ser Asn Cys Val Ala Asp Tyr Ser Phe Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  
Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  
Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      
Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
            100                 105                 110         
Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             
Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg 
    130                 135                 140                 
Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 
Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Gln Gly Phe 
                165                 170                 175     
Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
            180                 185                 190         
Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             
His Ala Pro Ala Thr Val Cys Gly Pro Lys Gly Ser Gly Leu Val Pro 
    210                 215                 220                 
Arg Gly Ser His His His His His His His His Ser Ala Trp Ser His 
225                 230                 235                 240 
Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                245                 250                 255     
Gln Lys Ile Glu Trp His Glu 
            260             

<210> 123
<211> 263
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic polypeptide (SARS-CoV-2 delta variant B.1.617.2/3 RBD
      domain)

<400> 123
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          
Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              
Ser Asn Cys Val Ala Asp Tyr Ser Phe Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  
Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  
Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      
Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
            100                 105                 110         
Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             
Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg 
    130                 135                 140                 
Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 
Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly Val Glu Gly Phe 
                165                 170                 175     
Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
            180                 185                 190         
Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             
His Ala Pro Ala Thr Val Cys Gly Pro Lys Gly Ser Gly Leu Val Pro 
    210                 215                 220                 
Arg Gly Ser His His His His His His His His Ser Ala Trp Ser His 
225                 230                 235                 240 
Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                245                 250                 255     
Gln Lys Ile Glu Trp His Glu 
            260             

<210> 124
<211> 263
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic polypeptide (SARS-CoV-2 delta plus variant)

<400> 124
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          
Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              
Ser Asn Cys Val Ala Asp Tyr Ser Phe Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  
Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  
Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      
Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn 
            100                 105                 110         
Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             
Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg 
    130                 135                 140                 
Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 
Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly Val Glu Gly Phe 
                165                 170                 175     
Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
            180                 185                 190         
Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             
His Ala Pro Ala Thr Val Cys Gly Pro Lys Gly Ser Gly Leu Val Pro 
    210                 215                 220                 
Arg Gly Ser His His His His His His His His Ser Ala Trp Ser His 
225                 230                 235                 240 
Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                245                 250                 255     
Gln Lys Ile Glu Trp His Glu 
            260             

<210> 125
<211> 263
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic polypeptide (SARS-CoV-2 omicron variant B.1.1.529 / RBD
      domain)

<400> 125
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asn Ile Thr Asn Leu Cys Pro Phe Asp Glu Val Phe 
            20                  25                  30          
Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              
Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu Ala Pro Phe 
    50                  55                  60                  
Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  
Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      
Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn 
            100                 105                 110         
Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             
Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    130                 135                 140                 
Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 
Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val Ala Gly Phe 
                165                 170                 175     
Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro Thr Tyr Gly 
            180                 185                 190         
Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             
His Ala Pro Ala Thr Val Cys Gly Pro Lys Gly Ser Gly Leu Val Pro 
    210                 215                 220                 
Arg Gly Ser His His His His His His His His Ser Ala Trp Ser His 
225                 230                 235                 240 
Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                245                 250                 255     
Gln Lys Ile Glu Trp His Glu 
            260             

<210> 126
<211> 1273
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic polypeptide (SARS-CoV-2 omicron variant B.1.1.529 /
      Spike ectodomain)

<400> 126
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  
Phe His Val Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  
Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser 
                85                  90                  95      
Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         
Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             
Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp His Lys Asn Asn 
    130                 135                 140                 
Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 
Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     
Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         
Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Ile Val Arg 
        195                 200                 205             
Glu Pro Glu Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 
Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 
Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     
Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         
Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             
Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 
Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 
Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp 
                325                 330                 335     
Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         
Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu 
        355                 360                 365             
Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 
Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 
Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     
Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         
Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr 
        435                 440                 445             
Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 
Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val 
465                 470                 475                 480 
Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro 
                485                 490                 495     
Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         
Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             
Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Lys 
    530                 535                 540                 
Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 
Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     
Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         
Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             
Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 
Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 
Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser 
                645                 650                 655     
Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         
Thr Gln Thr Lys Ser His Gly Ser Ala Gly Ser Val Ala Ser Gln Ser 
        675                 680                 685             
Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 
Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 
Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     
Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         
Tyr Gly Ser Phe Cys Thr Gln Leu Lys Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             
Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 
Ile Tyr Lys Thr Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 
Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu 
                805                 810                 815     
Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         
Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             
Ala Gln Lys Phe Lys Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 
Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 
Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro 
                885                 890                 895     
Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         
Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             
Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys 
    930                 935                 940                 
Leu Gln Asp Val Val Asn His Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 
Lys Gln Leu Ser Ser Lys Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     
Ile Phe Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         
Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln 
        995                 1000                1005            
Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala Thr 
    1010                1015                1020                
Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp Phe Cys 
1025                1030                1035                1040
Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala Pro His Gly 
                1045                1050                1055    
Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu Lys Asn Phe 
            1060                1065                1070        
Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His Phe Pro Arg 
        1075                1080                1085            
Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val Thr Gln Arg 
    1090                1095                1100                
Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr Phe Val Ser 
1105                1110                1115                1120
Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp 
                1125                1130                1135    
Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr 
            1140                1145                1150        
Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly 
        1155                1160                1165            
Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn 
    1170                1175                1180                
Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 
1185                1190                1195                1200
Gly Lys Tyr Glu Gln Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
                1205                1210                1215    
Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
            1220                1225                1230        
Phe Leu Gly Gly Ser His His His His His His His His Ser Ala Trp 
        1235                1240                1245            
Ser His Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn Asp Ile Phe 
    1250                1255                1260                
Glu Ala Gln Lys Ile Glu Trp His Glu 
1265                1270            

<210> 127
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Endoneous Leader Sequence

<400> 127
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly 
            20  

<210> 128
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Thrombin Cleavage Site

<400> 128
Leu Val Pro Arg Gly Ser 
1               5       

<210> 129
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Poly His-Tag

<400> 129
His His His His His His His His 
1               5               

<210> 130
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Foldon Trimerization motif

<400> 130
Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
1               5                   10                  15      
Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25      

<210> 131
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Avi-Tag

<400> 131
Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  

<210> 132
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> Constant Heavy Chain Region Prime

<400> 132
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 133
<211> 453
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.1169 Full length Heavy Chain Prime

<400> 133
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Ser 
            20                  25                  30          
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Pro Tyr Cys Ser Gly Gly Thr Cys Leu Asp Gly Phe Asp Ile 
            100                 105                 110         
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             
Leu Ser Pro Gly Lys 
    450             

<210> 134
<211> 447
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.1353 Full length Heavy Chain Prime

<400> 134
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Leu Gly Pro Met Gly Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210> 135
<211> 447
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.3194 Full length Heavy Chain Prime

<400> 135
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Thr Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Pro Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210> 136
<211> 447
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.3235 Full length Heavy Chain Prime

<400> 136
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Arg Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Gly Asp Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210> 137
<211> 447
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5213 Full length Heavy Chain Prime

<400> 137
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asp Leu Asn Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Ala Thr 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210> 138
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 HCDR1

<400> 138
Ser Ser Ala Val Gln 
1               5   

<210> 139
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 HCDR2

<400> 139
Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Glu 
    

<210> 140
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 HCDR3

<400> 140
Pro His Cys Ser Ser Thr Ser Cys Tyr Asp Ala Phe Asp Ile 
1               5                   10                  

<210> 141
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 LCDR1

<400> 141
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          

<210> 142
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 LCDR2

<400> 142
Gly Ala Ser Ser Arg Ala Thr 
1               5           

<210> 143
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 LCDR3

<400> 143
Gln Gln Tyr Gly Arg Ser Pro Trp Thr 
1               5                   

<210> 144
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 H-FR1

<400> 144
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr 
            20                  25                  30  

<210> 145
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 H-FR2

<400> 145
Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 146
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 H-FR3

<400> 146
Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          



<210> 147
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 H-FR4

<400> 147
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      

<210> 148
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 L-FR1

<400> 148
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys 
            20              

<210> 149
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 L-FR2

<400> 149
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 150
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 L-FR3

<400> 150
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Arg Leu Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          



<210> 151
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 L-FR4

<400> 151
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  

<210> 152
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 VH

<400> 152
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Pro His Cys Ser Ser Thr Ser Cys Tyr Asp Ala Phe Asp Ile 
            100                 105                 110         
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             

<210> 153
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 VL

<400> 153
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210> 154
<211> 453
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 Heavy chain

<400> 154
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Pro His Cys Ser Ser Thr Ser Cys Tyr Asp Ala Phe Asp Ile 
            100                 105                 110         
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             
Leu Ser Pro Gly Lys 
    450             

<210> 155
<211> 215
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5179 Light chain

<400> 155
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Ala Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

<210> 156
<211> 369
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid coding for Cv2.5179 Heavy chain

<400> 156
caggtgcagc tggtgcagtc tgggcctgag gtgaagaagc ctgggacctc agtgaaggtc      60

tcctgcaagg cttctggatt cacctttact agctctgctg tgcagtgggt gcgacaggcc     120

cgtggacaac gccttgagtg gataggatgg atcgtcgttg gcagtggtaa cacaaactac     180

gcacagaagt tccaagaaag agtcaccatt accagggaca tgtccacaag cacagcctac     240

atggagctga gcagcctgag atccgaggac acggccgtgt attactgtgc ggcaccacat     300

tgtagtagta ccagttgcta tgacgctttt gatatctggg gccaagggac aatggtcacc     360

gtctcttca                                                             369


<210> 157
<211> 324
<212> PRT
<213> Artificial Sequence


<220> 
<223> Nucleic acid coding for Cv2.5179 Light chain

<400> 157
Gly Ala Ala Ala Thr Thr Gly Thr Gly Thr Thr Gly Ala Cys Gly Cys 
1               5                   10                  15      
Ala Gly Thr Cys Thr Cys Cys Ala Gly Gly Cys Ala Cys Cys Cys Thr 
            20                  25                  30          
Gly Thr Cys Thr Thr Thr Gly Thr Cys Thr Cys Cys Ala Gly Gly Gly 
        35                  40                  45              
Gly Ala Ala Ala Gly Gly Gly Cys Cys Ala Cys Cys Cys Thr Cys Thr 
    50                  55                  60                  
Cys Cys Thr Gly Cys Ala Gly Gly Gly Cys Cys Ala Gly Thr Cys Ala 
65                  70                  75                  80  
Gly Ala Gly Thr Gly Thr Thr Ala Gly Cys Ala Gly Cys Ala Gly Cys 
                85                  90                  95      
Thr Ala Cys Thr Thr Ala Gly Cys Cys Thr Gly Gly Thr Ala Cys Cys 
            100                 105                 110         
Ala Gly Cys Ala Gly Ala Ala Ala Cys Cys Thr Gly Gly Cys Cys Ala 
        115                 120                 125             
Gly Gly Cys Thr Cys Cys Cys Ala Gly Gly Cys Thr Cys Cys Thr Cys 
    130                 135                 140                 
Ala Thr Cys Thr Ala Thr Gly Gly Thr Gly Cys Ala Thr Cys Cys Ala 
145                 150                 155                 160 
Gly Cys Ala Gly Gly Gly Cys Cys Ala Cys Thr Gly Gly Cys Ala Thr 
                165                 170                 175     
Cys Cys Cys Ala Gly Ala Cys Ala Gly Gly Thr Thr Cys Ala Gly Thr 
            180                 185                 190         
Gly Gly Cys Ala Gly Thr Gly Gly Gly Thr Cys Thr Gly Gly Gly Ala 
        195                 200                 205             
Cys Ala Gly Ala Cys Thr Thr Cys Ala Cys Thr Cys Thr Cys Ala Cys 
    210                 215                 220                 
Cys Ala Thr Cys Ala Gly Cys Ala Gly Ala Cys Thr Gly Gly Ala Gly 
225                 230                 235                 240 
Gly Cys Thr Gly Ala Ala Gly Ala Thr Thr Thr Thr Gly Cys Ala Gly 
                245                 250                 255     
Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr Cys Ala Gly Cys Ala 
            260                 265                 270         
Gly Thr Ala Thr Gly Gly Thr Ala Gly Gly Thr Cys Ala Cys Cys Gly 
        275                 280                 285             
Thr Gly Gly Ala Cys Gly Thr Thr Cys Gly Gly Cys Cys Ala Ala Gly 
    290                 295                 300                 
Gly Gly Ala Cys Cys Ala Ala Gly Cys Thr Gly Gly Ala Gly Ala Thr 
305                 310                 315                 320 
Cys Ala Ala Ala 
                

<210> 158
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5156 VH

<400> 158
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asn Tyr Cys Ser Ser Thr Ser Cys Ser Asp Ala Phe Asp Ile 
            100                 105                 110         
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             

<210> 159
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.5156 VL

<400> 159
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      
Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     

<210> 160
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.1174 VH

<400> 160
Glu Val Gln Leu Val Glu Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Arg Ser 
            20                  25                  30          
Ala Met Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Gln Asp Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210> 161
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.1174 VL

<400> 161
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Met Ser Asn Ser 
            20                  25                  30          
Leu Asp Trp Asp Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 
        35                  40                  45              
Tyr Ala Ala Ser Arg Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Asp Pro Pro 
                85                  90                  95      
Lys Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 162
<211> 128
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.1388 VH

<400> 162
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser 
            20                  25                  30          
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Val Val Gly Ser Gly Asp Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asp Arg Gln Ala Gly Ser Arg Thr Tyr Tyr Phe Pro Gly Glu 
            100                 105                 110         
Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             



<210> 163
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.1388 VL

<400> 163
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      
Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Thr Asn Ile Gly Asn Asn 
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Arg Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      
Ser Gly Val Val Phe Arg Arg Arg Asp Gln Ala Asp Arg Pro Arg 
            100                 105                 110     

<210> 164
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.3132 VH

<400> 164
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Val Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Tyr Tyr Tyr Asp Ser Ser Gly Tyr Trp Lys Arg Leu Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 165
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cv2.3132 VL

<400> 165
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr His Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 166
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> Casirivimab VH

<400> 166
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Thr Tyr Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Gly Thr Thr Met Val Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 167
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Casirivimab VL

<400> 167
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 168
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> Etesevimab VH

<400> 168
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Phe Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Val Leu Pro Met Tyr Gly Asp Tyr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 169
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Etesevimab VL

<400> 169
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      
Glu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 

<210> 170
<211> 128
<212> PRT
<213> Artificial Sequence


<220> 
<223> Regdanvimab VH

<400> 170
Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr His Thr Thr Ser 
    50                  55                  60                  
Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 
            100                 105                 110         
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             



<210> 171
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> Regdanvimab VL

<400> 171
Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      
Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  
Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      
Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 
            100                 105                 110 

<210> 172
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> Tixagevimab VH

<400> 172
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Met Ser Ser 
            20                  25                  30          
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Val Ile Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Pro Tyr Cys Ser Ser Ile Ser Cys Asn Asp Gly Phe Asp Ile 
            100                 105                 110         
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             

<210> 173
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Tixagevimab VL

<400> 173
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Arg 
                85                  90                  95      
Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 

<210> 174
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Adintrevimab VH

<400> 174
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Glu Asp Gly Tyr Ser Thr Tyr Tyr Pro Asp Ser Leu 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Phe Ser Gly His Thr Ala Trp Ala Gly Thr Gly Phe Glu 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 

<210> 175
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> Adintrevimab VL

<400> 175
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      
Arg Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Ser Ser Ser Arg Asn Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      
Leu Ser Val Leu Tyr Thr Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         



<210> 176
<211> 125
<212> PRT
<213> Artificial Sequence


<220> 
<223> Bamlanivimab VH

<400> 176
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Tyr Tyr Glu Ala Arg His Tyr Tyr Tyr Tyr Tyr Ala Met 
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120                 125 

<210> 177
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Bamlanivimab VL

<400> 177
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 178
<211> 131
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cilgavimab VH

<400> 178
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Val 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Lys Ser Lys Ile Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Thr Thr Ala Gly Ser Tyr Tyr Tyr Asp Thr Val Gly Pro Gly 
            100                 105                 110         
Leu Pro Glu Gly Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             
Val Ser Ser 
    130     

<210> 179
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> Cilgavimab VL

<400> 179
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Met Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Ser Thr Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         



<210> 180
<211> 127
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sotrovimab VH

<400> 180
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr 
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Ser Thr Tyr Gln Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr 
65                  70                  75                  80  
Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly 
            100                 105                 110         
Gly Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         

<210> 181
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Sotrovimab VL

<400> 181
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Thr 
            20                  25                  30          
Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asp Thr Ser Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 182
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> Imdevimab VH

<400> 182
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gly Ser Asp Tyr Gly Asp Tyr Leu Leu Val Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 183
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> Imdevimab VL

<400> 183
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Leu Thr Ser Ile 
                85                  90                  95      
Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 

<210> 184
<211> 263
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic polypeptide (Omicron subvariant BA.2)

<400> 184
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asn Ile Thr Asn Leu Cys Pro Phe Asp Glu Val Phe 
            20                  25                  30          
Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              
Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Phe Ala Pro Phe 
    50                  55                  60                  
Phe Ala Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  
Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asn Glu 
                85                  90                  95      
Val Ser Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn 
            100                 105                 110         
Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             
Asn Lys Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    130                 135                 140                 
Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 
Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val Ala Gly Phe 
                165                 170                 175     
Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Gly Phe Arg Pro Thr Tyr Gly 
            180                 185                 190         
Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             
His Ala Pro Ala Thr Val Cys Gly Pro Lys Gly Ser Gly Leu Val Pro 
    210                 215                 220                 
Arg Gly Ser His His His His His His His His Ser Ala Trp Ser His 
225                 230                 235                 240 
Pro Gln Phe Glu Lys Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                245                 250                 255     
Gln Lys Ile Glu Trp His Glu 
            260             

