                         б

<110>  ɳƼ޹˾
麣Ƽ޹˾
ϺɳƼ޹˾
麣ɳƼ޹˾

<120>  һεܰϸ;

<130>  0170-PA-043

<160>  82

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  gRNA óЧʼ

<400>  1
ggagaatgac gagtggaccc                                                   20


<210>  2
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OKT3HCDR1

<400>  2

Gly Tyr Thr Phe Thr Arg Tyr Thr 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OKT3HCDR2

<400>  3

Ile Asn Pro Ser Arg Gly Tyr Thr 
1               5               


<210>  4
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OKT3HCDR3

<400>  4

Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr 
1               5                   10          


<210>  5
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OKT3LCDR1

<400>  5

Ser Ser Val Ser Tyr 
1               5   


<210>  6
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OKT3LCDR2

<400>  6

Asp Thr Ser 
1           


<210>  7
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OKT3LCDR3

<400>  7

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  8
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OKT3ɱVH

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  9
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OKT3ɱVL

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
            100                 105     


<210>  10
<211>  222
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OKT3

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  11
<211>  213
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  OKT3

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  12
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP34HCDR1

<400>  12

Thr Tyr Ala Met Asn 
1               5   


<210>  13
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP34HCDR2

<400>  13

Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  14
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP34HCDR3

<400>  14

His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP34LCDR1

<400>  15

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  16
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP34LCDR2

<400>  16

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP34LCDR3

<400>  17

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  18
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP34ɱVH

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  19
<211>  109
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP34ɱVL

<400>  19

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  20
<211>  228
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP34

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys 
225             


<210>  21
<211>  216
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SP34

<400>  21

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  22
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8HCDR1

<400>  22

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  23
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8HCDR2

<400>  23

Ile Trp Ala Gly Gly Ser Thr 
1               5           


<210>  24
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8HCDR3

<400>  24

Ala Arg Asp Lys Arg Ala Pro Gly Lys Leu Tyr Tyr Gly Tyr Pro Asp 
1               5                   10                  15      


Tyr 
    


<210>  25
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8LCDR1

<400>  25

Glu Ser Val Glu Tyr Tyr Val Thr Ser Leu 
1               5                   10  


<210>  26
<211>  3
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8LCDR2

<400>  26

Ala Ala Ser 
1           


<210>  27
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8LCDR3

<400>  27

Gln Gln Thr Arg Lys Val Pro Ser Thr 
1               5                   


<210>  28
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8ɱVH 1

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Arg Ala Pro Gly Lys Leu Tyr Tyr Gly Tyr Pro Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120             


<210>  29
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8ɱVH 2

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Arg Ala Pro Gly Lys Leu Tyr Tyr Gly Tyr Pro Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120             


<210>  30
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8ɱVL

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Thr Arg 
                85                  90                  95      


Lys Val Pro Ser Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  31
<211>  226
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8 1

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Arg Ala Pro Gly Lys Leu Tyr Tyr Gly Tyr Pro Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys 
225     


<210>  32
<211>  226
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8 2

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Arg Ala Pro Gly Lys Leu Tyr Tyr Gly Tyr Pro Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys 
225     


<210>  33
<211>  218
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  15E8

<400>  33

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Val Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Pro Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Thr Arg 
                85                  90                  95      


Lys Val Pro Ser Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  34
<211>  629
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mbIL-12

<400>  34

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Gln Lys Met Gly Gly Phe Gln Asn Ser Arg Arg Cys Leu Cys 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Leu Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu Asn Phe Gly Val Ile Gly Pro Gln Arg Asp Glu Lys Phe 
    50                  55                  60                  


Pro Asn Gly Leu Pro Leu Ile Ser Ser Met Ala Met Cys His Gln Gln 
65                  70                  75                  80  


Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu Val 
                85                  90                  95      


Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
            100                 105                 110         


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
        115                 120                 125             


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
    130                 135                 140                 


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
145                 150                 155                 160 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
                165                 170                 175     


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
            180                 185                 190         


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
        195                 200                 205             


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
    210                 215                 220                 


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
225                 230                 235                 240 


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
                245                 250                 255     


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
            260                 265                 270         


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
        275                 280                 285             


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
    290                 295                 300                 


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
305                 310                 315                 320 


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
                325                 330                 335     


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
            340                 345                 350         


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
        355                 360                 365             


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
    370                 375                 380                 


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
385                 390                 395                 400 


Pro Cys Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
                405                 410                 415     


Gly Ser Thr Lys Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Ala 
            420                 425                 430         


Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
        435                 440                 445             


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
    450                 455                 460                 


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
465                 470                 475                 480 


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
                485                 490                 495     


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
            500                 505                 510         


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
        515                 520                 525             


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
    530                 535                 540                 


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
545                 550                 555                 560 


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
                565                 570                 575     


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
            580                 585                 590         


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
        595                 600                 605             


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
    610                 615                 620                 


Tyr Leu Asn Ala Ser 
625                 


<210>  35
<211>  610
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mbIL-12-B7

<400>  35

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Ser Thr Ser Gly Ser Gly Lys 
                325                 330                 335     


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Val Pro Gly Val Gly Val 
            340                 345                 350         


Pro Gly Val Gly Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
        355                 360                 365             


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
    370                 375                 380                 


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
385                 390                 395                 400 


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
                405                 410                 415     


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
            420                 425                 430         


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
        435                 440                 445             


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
    450                 455                 460                 


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
465                 470                 475                 480 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
                485                 490                 495     


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
            500                 505                 510         


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
        515                 520                 525             


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
    530                 535                 540                 


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Thr Thr Lys Gln Glu His 
545                 550                 555                 560 


Phe Pro Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val 
                565                 570                 575     


Asn Gly Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg 
            580                 585                 590         


Cys Arg Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg 
        595                 600                 605             


Pro Val 
    610 


<210>  36
<211>  575
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mbIL12-CD8R

<400>  36

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Ser Thr Ser Gly Ser Gly Lys 
                325                 330                 335     


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Val Pro Gly Val Gly Val 
            340                 345                 350         


Pro Gly Val Gly Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
        355                 360                 365             


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
    370                 375                 380                 


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
385                 390                 395                 400 


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
                405                 410                 415     


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
            420                 425                 430         


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
        435                 440                 445             


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
    450                 455                 460                 


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
465                 470                 475                 480 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
                485                 490                 495     


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
            500                 505                 510         


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
        515                 520                 525             


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
    530                 535                 540                 


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Ile Trp Ala Pro Leu Ala 
545                 550                 555                 560 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                565                 570                 575 


<210>  37
<211>  581
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mbIL12-CD28

<400>  37

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Ser Thr Ser Gly Ser Gly Lys 
                325                 330                 335     


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Val Pro Gly Val Gly Val 
            340                 345                 350         


Pro Gly Val Gly Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
        355                 360                 365             


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
    370                 375                 380                 


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
385                 390                 395                 400 


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
                405                 410                 415     


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
            420                 425                 430         


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
        435                 440                 445             


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
    450                 455                 460                 


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
465                 470                 475                 480 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
                485                 490                 495     


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
            500                 505                 510         


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
        515                 520                 525             


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
    530                 535                 540                 


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Phe Trp Val Leu Val Val 
545                 550                 555                 560 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                565                 570                 575     


Ile Ile Phe Trp Val 
            580     


<210>  38
<211>  616
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mbIL12-IL15R

<400>  38

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Ser Thr Ser Gly Ser Gly Lys 
                325                 330                 335     


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Val Pro Gly Val Gly Val 
            340                 345                 350         


Pro Gly Val Gly Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
        355                 360                 365             


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
    370                 375                 380                 


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
385                 390                 395                 400 


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
                405                 410                 415     


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
            420                 425                 430         


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
        435                 440                 445             


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
    450                 455                 460                 


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
465                 470                 475                 480 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
                485                 490                 495     


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
            500                 505                 510         


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
        515                 520                 525             


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
    530                 535                 540                 


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Val Ala Ile Ser Thr Ser 
545                 550                 555                 560 


Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr 
                565                 570                 575     


Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala 
            580                 585                 590         


Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp 
        595                 600                 605             


Leu Glu Asn Cys Ser His His Leu 
    610                 615     


<210>  39
<211>  603
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mbIL12-PDGFR

<400>  39

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Ser Thr Ser Gly Ser Gly Lys 
                325                 330                 335     


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Val Pro Gly Val Gly Val 
            340                 345                 350         


Pro Gly Val Gly Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
        355                 360                 365             


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
    370                 375                 380                 


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
385                 390                 395                 400 


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
                405                 410                 415     


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
            420                 425                 430         


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
        435                 440                 445             


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
    450                 455                 460                 


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
465                 470                 475                 480 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
                485                 490                 495     


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
            500                 505                 510         


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
        515                 520                 525             


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
    530                 535                 540                 


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Val Gly Gln Asp Thr Gln 
545                 550                 555                 560 


Glu Val Ile Val Val Pro His Ser Leu Pro Phe Lys Val Val Val Ile 
                565                 570                 575     


Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser Leu Ile Ile 
            580                 585                 590         


Leu Ile Met Leu Trp Gln Lys Lys Pro Arg Tyr 
        595                 600             


<210>  40
<211>  623
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mbIL12-HAstalk

<400>  40

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Ser Thr Ser Gly Ser Gly Lys 
                325                 330                 335     


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Val Pro Gly Val Gly Val 
            340                 345                 350         


Pro Gly Val Gly Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
        355                 360                 365             


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
    370                 375                 380                 


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
385                 390                 395                 400 


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
                405                 410                 415     


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
            420                 425                 430         


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
        435                 440                 445             


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
    450                 455                 460                 


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
465                 470                 475                 480 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
                485                 490                 495     


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
            500                 505                 510         


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
        515                 520                 525             


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
    530                 535                 540                 


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Asn Gly Thr Tyr Asp Tyr 
545                 550                 555                 560 


Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly 
                565                 570                 575     


Val Lys Leu Glu Ser Met Gly Val Tyr Gln Ile Leu Ala Ile Tyr Ser 
            580                 585                 590         


Thr Val Ala Ser Ser Leu Val Leu Leu Val Ser Leu Gly Ala Ile Ser 
        595                 600                 605             


Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
    610                 615                 620             


<210>  41
<211>  22
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  SGN

<400>  41

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala 
            20          


<210>  42
<211>  306
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IL-12 p40

<400>  42

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  43
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker

<400>  43

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  44
<211>  46
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker1

<400>  44

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  45
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker2

<400>  45

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  46
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker3

<400>  46

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  47
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker4

<400>  47

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  48
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker5

<400>  48

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  49
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker6

<400>  49

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  50
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker7

<400>  50

Glu Ala Ala Ala Lys 
1               5   


<210>  51
<211>  2
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker8

<400>  51

Ala Pro 
1       


<210>  52
<211>  2
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker9

<400>  52

Glu Pro 
1       


<210>  53
<211>  2
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker10

<400>  53

Lys Pro 
1       


<210>  54
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Linker11

<400>  54

Gly Gly Gly Gly Ser 
1               5   


<210>  55
<211>  208
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IL-12 p35

<400>  55

Val Pro Gly Val Gly Val Pro Gly Val Gly Ala Arg Asn Leu Pro Val 
1               5                   10                  15      


Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn 
            20                  25                  30          


Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu 
        35                  40                  45              


Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr 
    50                  55                  60                  


Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr 
65                  70                  75                  80  


Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn 
                85                  90                  95      


Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys 
            100                 105                 110         


Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys 
        115                 120                 125             


Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu 
    130                 135                 140                 


Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn 
145                 150                 155                 160 


Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp 
                165                 170                 175     


Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg 
            180                 185                 190         


Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
        195                 200                 205             


<210>  56
<211>  40
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TM

<400>  56

Phe Ser Phe Leu Leu Val Ala Gly Ala Thr Thr Leu Phe Cys Leu Leu 
1               5                   10                  15      


Asn Phe Gly Val Ile Gly Pro Gln Arg Asp Glu Lys Phe Pro Asn Gly 
            20                  25                  30          


Leu Pro Leu Ile Ser Ser Met Ala 
        35                  40  


<210>  57
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TM1

<400>  57

Phe Ser Phe Leu Leu Val Ala Gly Ala Thr Thr Leu Phe Cys Leu Leu 
1               5                   10                  15      


Asn Phe Gly Val Ile 
            20      


<210>  58
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TM2

<400>  58

Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser 
1               5                   10                  15      


Leu Ile Ile Leu Ile 
            20      


<210>  59
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TM3

<400>  59

Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
1               5                   10                  15      


Ser Leu Gly Ala Ile 
            20      


<210>  60
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TM4

<400>  60

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  61
<211>  27
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  TM5

<400>  61

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  62
<211>  35
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CY

<400>  62

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Gln Lys Met Gly Gly Phe Gln Asn Ser Arg Arg Cys Leu Cys 
            20                  25                  30          


Leu Ser Leu 
        35  


<210>  63
<211>  39
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CY1

<400>  63

Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
1               5                   10                  15      


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
            20                  25                  30          


Glu Asn Cys Ser His His Leu 
        35                  


<210>  64
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CY2

<400>  64

Met Leu Trp Gln Lys Lys Pro Arg Tyr 
1               5                   


<210>  65
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CY3

<400>  65

Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
1               5                   10                  15      


<210>  66
<211>  56
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  B7 TM+CY

<400>  66

Thr Thr Lys Gln Glu His Phe Pro Asp Asn Leu Leu Pro Ser Trp Ala 
1               5                   10                  15      


Ile Thr Leu Ile Ser Val Asn Gly Ile Phe Val Ile Cys Cys Leu Thr 
            20                  25                  30          


Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg Asn Glu Arg Leu 
        35                  40                  45              


Arg Arg Glu Ser Val Arg Pro Val 
    50                  55      


<210>  67
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8R TM+CY

<400>  67

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr 
            20      


<210>  68
<211>  62
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IL15R TM+CY

<400>  68

Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val 
1               5                   10                  15      


Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala 
            20                  25                  30          


Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr 
        35                  40                  45              


Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
    50                  55                  60          


<210>  69
<211>  49
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PDGFR TM+CY

<400>  69

Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro 
1               5                   10                  15      


Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr 
            20                  25                  30          


Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
        35                  40                  45              


Tyr 
    


<210>  70
<211>  69
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HAstalk TM+CY

<400>  70

Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
1               5                   10                  15      


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
            20                  25                  30          


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
        35                  40                  45              


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
    50                  55                  60                  


Cys Arg Ile Cys Ile 
65                  


<210>  71
<211>  331
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  c-Jun prt

<400>  71

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
    210                 215                 220                 


Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                245                 250                 255     


Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
            260                 265                 270         


Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
        275                 280                 285             


Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
    290                 295                 300                 


Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
305                 310                 315                 320 


Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                325                 330     


<210>  72
<211>  1008
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  c-Jun nt 1

<400>  72
ttacaggcgg ccatgactgc aaagatggaa acgaccttct atgacgatgc cctcaacgcc       60

tcgttcctcc cgtccgagag cggaccttat ggctacagta accccaagat cctgaaacag      120

agcatgaccc tgaacctggc cgacccagtg gggagcctga agccgcacct ccgcgccaag      180

aactcggacc tcctcacctc gcccgacgtg gggctgctca agctggcgtc gcccgagctg      240

gagcgcctga taatccagtc cagcaacggg cacatcacca ccacgccgac ccccacccag      300

ttcctgtgcc ccaagaacgt gacagatgag caggagggct tcgccgaggg cttcgtgcgc      360

gccctggccg aactgcacag ccagaacacg ctgcccagcg tcacgtcggc ggcgcagccg      420

gtcaacgggg caggcatggt ggctcccgcg gtagcctcgg tggcaggggg cagcggcagc      480

ggcggcttca gcgccagcct gcacagcgag ccgccggtct acgcaaacct cagcaacttc      540

aacccaggcg cgctgagcag cggcggcggg gcgccctcct acggcgcggc cggcctggcc      600

tttcccgcgc aaccccagca gcagcagcag ccgccgcacc acctgcccca gcagatgccc      660

gtgcagcacc cgcggctgca ggccctgaag gaggagcctc agacagtgcc cgagatgccc      720

ggcgagacac cgcccctgtc ccccatcgac atggagtccc aggagcggat caaggcggag      780

aggaagcgca tgaggaaccg catcgctgcc tccaagtgcc gaaaaaggaa gctggagaga      840

atcgcccggc tggaggaaaa agtgaaaacc ttgaaagctc agaactcgga gctggcgtcc      900

acggccaaca tgctcaggga acaggtggca cagcttaaac agaaagtcat gaaccacgtt      960

aacagtgggt gccaactcat gctaacgcag cagttgcaaa cattttga                  1008


<210>  73
<211>  996
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  c-Jun nt 2

<400>  73
atgaccgcca agatggagac caccttctac gacgacgccc tgaacgctag cttcctgcct       60

agcgagagcg gcccctacgg ctacagcaac cccaagatcc tgaagcagag catgaccctg      120

aacctggccg accccgtggg cagcctgaag ccccacctga gagccaagaa cagcgacctg      180

ctgacaagcc ccgacgtggg cctgctgaag ctggctagcc ccgagctgga gagactgatc      240

attcagagca gcaacggcca catcaccaca acccccaccc ccacacagtt cctgtgcccc      300

aagaacgtga ccgacgagca agagggcttc gccgagggct tcgtgagagc cctggccgag      360

ctgcacagcc aaaacaccct gcctagcgtc acaagcgctg ctcagcccgt caacggcgct      420

ggcatggtcg cccctgctgt cgctagcgtg gccggcggca gcggcagcgg cggcttctcc      480

gctagcctgc acagcgagcc ccccgtgtac gccaacctgt ccaatttcaa ccccggcgcc      540

ctgagcagcg gcgggggcgc ccctagctac ggcgccgccg ggctggcttt ccccgctcag      600

ccccaacagc aacagcagcc tccccaccac ctgcctcagc agatgcccgt gcagcaccct      660

agactgcaag ccctcaagga ggagcctcag accgtgcccg agatgcccgg cgagaccccc      720

cccctgagcc ccatcgacat ggagagccaa gagagaatca aggccgagag aaagagaatg      780

agaaacagaa tcgccgctag caagtgcaga aagagaaagc tggagagaat cgctagactg      840

gaggagaagg tgaagaccct gaaggctcag aacagcgagc tggctagcac cgccaacatg      900

ctgagagagc aagtggctca gctgaagcag aaggtgatga accacgtgaa cagcggctgt      960

cagctgatgc tgacacagca gctgcagacc ttctga                                996


<210>  74
<211>  272
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  miR155 1

<400>  74
ctttatgcct catcctctga gtgctgaagg cttgctgtag gctgtatgct gttaatgcta       60

atcgtgatag gggtttttgc ctccaactga ctcctacata ttagcattaa cagtgtatga      120

tgcctgttac tagcattcac atggaacaaa ttgctgccgt gggaggatga caaagaagca      180

tgagtcaccc tgctggataa acttagactt caggctttat catttttcaa tctgttaatc      240

ataatctggt cactgggatg ttcaaccttc gt                                    272


<210>  75
<211>  2181
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  miR155 2

<400>  75
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg ctttatgcct catcctctga gtgctgaagg cttgctgtag gctgtatgct      300

gttaatgcta atcgtgatag gggtttttgc ctccaactga ctcctacata ttagcattaa      360

cagtgtatga tgcctgttac tagcattcac atggaacaaa ttgctgccgt gggaggatga      420

caaagaagca tgagtcaccc tgctggataa acttagactt caggctttat catttttcaa      480

tctgttaatc ataatctggt cactgggatg ttcaaccttc gtttttttta ctcgagttat      540

ataccccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg tgtgcgtttg      600

tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc cggaaacctg      660

gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa ggaatgcaag      720

gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga caaacaacgt      780

ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc      840

aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc cacgttgtga      900

gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac aaggggctga      960

aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg tgcacatgct     1020

ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc cccgaaccac ggggacgtgg     1080

ttttcctttg aaaaacacga taataccatg ttgctccttg tgacgagcct cctgctctgc     1140

gagctgcccc atccagcctt cctcctcatc ccgcggaagg tgtgcaatgg cataggcatt     1200

ggcgagttta aagattctct gagcataaat gctacgaata ttaagcattt caagaattgt     1260

acttctatta gtggcgacct ccatattctt ccggttgcct tcaggggtga ctctttcacc     1320

cacacacctc cattggatcc acaagaactt gacatcctga agacggttaa agagattaca     1380

ggcttcctcc ttatccaagc gtggcccgag aacagaacgg acttgcacgc ctttgagaac     1440

ctcgaaataa tacggggtcg gacgaagcaa cacggccaat ttagccttgc ggttgttagt     1500

ctgaacatta cttctctcgg ccttcgctct ttgaaagaaa tcagcgacgg agatgtcatc     1560

attagtggaa acaagaacct gtgctacgcg aacacaatca actggaagaa gctcttcggt     1620

acttcaggcc aaaagacaaa gattattagt aacagaggag agaatagctg taaggctacc     1680

ggacaagttt gtcacgcctt gtgtagtcca gagggttgct ggggaccgga accaagggat     1740

tgcgtcagtt gccggaacgt gagtcgcgga cgcgagtgtg tggataagtg caatcttctg     1800

gaaggggaac cgcgagagtt tgtagaaaat tccgaatgta tacagtgtca tcccgagtgt     1860

cttccacaag caatgaatat cacatgtaca gggaggggtc ctgataactg tatccaatgt     1920

gcacactaca tagatggtcc tcactgtgta aagacgtgcc ccgccggagt aatgggtgaa     1980

aacaacaccc tcgtgtggaa gtacgccgat gccgggcatg tctgtcattt gtgtcatccc     2040

aactgcacat atggctgtac cggtcctgga ttggagggct gtccaacaaa cgggccgaaa     2100

ataccgagta tcgcaacagg catggtggga gcacttttgc ttctcctcgt tgtcgccctg     2160

ggcatcggct tgttcatgtg a                                               2181


<210>  76
<211>  241
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  miR155 2 U6 promoter

<400>  76
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  77
<211>  564
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  miR155 2 IRES

<400>  77
cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct       60

atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc      120

ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc      180

tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg      240

tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa      300

agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt      360

ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg      420

atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta      480

catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt      540

tcctttgaaa aacacgataa tacc                                             564


<210>  78
<211>  1074
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  miR155 2 tEGFR

<400>  78
atgttgctcc ttgtgacgag cctcctgctc tgcgagctgc cccatccagc cttcctcctc       60

atcccgcgga aggtgtgcaa tggcataggc attggcgagt ttaaagattc tctgagcata      120

aatgctacga atattaagca tttcaagaat tgtacttcta ttagtggcga cctccatatt      180

cttccggttg ccttcagggg tgactctttc acccacacac ctccattgga tccacaagaa      240

cttgacatcc tgaagacggt taaagagatt acaggcttcc tccttatcca agcgtggccc      300

gagaacagaa cggacttgca cgcctttgag aacctcgaaa taatacgggg tcggacgaag      360

caacacggcc aatttagcct tgcggttgtt agtctgaaca ttacttctct cggccttcgc      420

tctttgaaag aaatcagcga cggagatgtc atcattagtg gaaacaagaa cctgtgctac      480

gcgaacacaa tcaactggaa gaagctcttc ggtacttcag gccaaaagac aaagattatt      540

agtaacagag gagagaatag ctgtaaggct accggacaag tttgtcacgc cttgtgtagt      600

ccagagggtt gctggggacc ggaaccaagg gattgcgtca gttgccggaa cgtgagtcgc      660

ggacgcgagt gtgtggataa gtgcaatctt ctggaagggg aaccgcgaga gtttgtagaa      720

aattccgaat gtatacagtg tcatcccgag tgtcttccac aagcaatgaa tatcacatgt      780

acagggaggg gtcctgataa ctgtatccaa tgtgcacact acatagatgg tcctcactgt      840

gtaaagacgt gccccgccgg agtaatgggt gaaaacaaca ccctcgtgtg gaagtacgcc      900

gatgccgggc atgtctgtca tttgtgtcat cccaactgca catatggctg taccggtcct      960

ggattggagg gctgtccaac aaacgggccg aaaataccga gtatcgcaac aggcatggtg     1020

ggagcacttt tgcttctcct cgttgtcgcc ctgggcatcg gcttgttcat gtga           1074


<210>  79
<211>  2422
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  miR155 3

<400>  79
gccaccatgt tgctccttgt gacgagcctc ctgctctgcg agctgcccca tccagccttc       60

ctcctcatcc cgcggaaggt gtgcaatggc ataggcattg gcgagtttaa agattctctg      120

agcataaatg ctacgaatat taagcatttc aagaattgta cttctattag tggcgacctc      180

catattcttc cggttgcctt caggggtgac tctttcaccc acacacctcc attggatcca      240

caagaacttg acatcctgaa gacggttaaa gagattacag gcttcctcct tatccaagcg      300

tggcccgaga acagaacgga cttgcacgcc tttgagaacc tcgaaataat acggggtcgg      360

acgaagcaac acggccaatt tagccttgcg gttgttagtc tgaacattac ttctctcggc      420

cttcgctctt tgaaagaaat cagcgacgga gatgtcatca ttagtggaaa caagaacctg      480

tgctacgcga acacaatcaa ctggaagaag ctcttcggta cttcaggcca aaagacaaag      540

attattagta acagaggaga gaatagctgt aaggctaccg gacaagtttg tcacgccttg      600

tgtagtccag agggttgctg gggaccggaa ccaagggatt gcgtcagttg ccggaacgtg      660

agtcgcggac gcgagtgtgt ggataagtgc aatcttctgg aaggggaacc gcgagagttt      720

gtagaaaatt ccgaatgtat acagtgtcat cccgagtgtc ttccacaagc aatgaatatc      780

acatgtacag ggaggggtcc tgataactgt atccaatgtg cacactacat agatggtcct      840

cactgtgtaa agacgtgccc cgccggagta atgggtgaaa acaacaccct cgtgtggaag      900

tacgccgatg ccgggcatgt ctgtcatttg tgtcatccca actgcacata tggctgtacc      960

ggtcctggat tggagggctg tccaacaaac gggccgaaaa taccgagtat cgcaacaggc     1020

atggtgggag cacttttgct tctcctcgtt gtcgccctgg gcatcggctt gttcatgtga     1080

gaattcgagc atcttaccgc catttattcc catatttgtt ctgtttttct tgatttgggt     1140

atacatttaa atgttaataa aacaaaatgg tggggcaatc atttacattt tatgggatat     1200

gtaattacta gttcaggtgt attgccacaa gacaaacatg ttaagaaact ttcccgttat     1260

ttacgctctg ttcctgttaa tcaacctctg gattacaaaa tttgtgaaag attgactgat     1320

attcttaact atgttgctcc ttttacgctg tgtggatatg ctgctttaat gcctctgtat     1380

catgctattg cttcccgtac ggctttcgtt ttctcctcct tgtataaatc ctggttgctg     1440

tctctttatg aggagttgtg gcccgttgtc cgtcaacgtg gcgtggtgtg ctctgtgttt     1500

gctgacgcaa cccccactgg ctggggcatt gccaccacct gtcaactcct ttctgggact     1560

ttcgctttcc ccctcccgat cgccacggca gaactcatcg ccgcctgcct tgcccgctgc     1620

tggacagggg ctaggttgct gggcactgat aattccgtgg tgttgtcggg gaaatcatcg     1680

tcctttcctt ggctgctcgc ctgtgttgcc aactggatcc tgcgcgggac gtccttctgc     1740

tacgtccctt cggctctcaa tccagcggac ctcccttccc gaggccttct gccggttctg     1800

cggcctctcc cgcgtcttcg ctttcggcct ccgacgagtc ggatctccct ttgggccgcc     1860

tccccgcctg tttcgcctcg gcgtccggtc cgtgttgctt ggtcgtcacc tgtgcagaat     1920

tgcgaaccat ggattccacc gtgaactttg tctcctggca tgcaaatcgt caacttggca     1980

tgccaagaat aattcggatc caagcttagg cctgctcgct ttcttgctgt cccatttcta     2040

ttaaaggttc ctttgttccc taagtccaac tactaaactg ggggatatta tgaagggcct     2100

tgagcatctg gattctgcct agcctttatg cctcatcctc tgagtgctga aggcttgctg     2160

taggctgtat gctgttaatg ctaatcgtga taggggtttt tgcctccaac tgactcctac     2220

atattagcat taacagtgta tgatgcctgt tactagcatt cacatggaac aaattgctgc     2280

cgtgggagga tgacaaagaa gcatgagtca ccctgctgga taaacttaga cttcaggctt     2340

tatcattttt caatctgtta atcataatct ggtcactggg atgttcaacc ttcgtgctaa     2400

gcttaacacg agccatagat ag                                              2422


<210>  80
<211>  1080
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  miR155 3 tEGFR

<400>  80
gccaccatgt tgctccttgt gacgagcctc ctgctctgcg agctgcccca tccagccttc       60

ctcctcatcc cgcggaaggt gtgcaatggc ataggcattg gcgagtttaa agattctctg      120

agcataaatg ctacgaatat taagcatttc aagaattgta cttctattag tggcgacctc      180

catattcttc cggttgcctt caggggtgac tctttcaccc acacacctcc attggatcca      240

caagaacttg acatcctgaa gacggttaaa gagattacag gcttcctcct tatccaagcg      300

tggcccgaga acagaacgga cttgcacgcc tttgagaacc tcgaaataat acggggtcgg      360

acgaagcaac acggccaatt tagccttgcg gttgttagtc tgaacattac ttctctcggc      420

cttcgctctt tgaaagaaat cagcgacgga gatgtcatca ttagtggaaa caagaacctg      480

tgctacgcga acacaatcaa ctggaagaag ctcttcggta cttcaggcca aaagacaaag      540

attattagta acagaggaga gaatagctgt aaggctaccg gacaagtttg tcacgccttg      600

tgtagtccag agggttgctg gggaccggaa ccaagggatt gcgtcagttg ccggaacgtg      660

agtcgcggac gcgagtgtgt ggataagtgc aatcttctgg aaggggaacc gcgagagttt      720

gtagaaaatt ccgaatgtat acagtgtcat cccgagtgtc ttccacaagc aatgaatatc      780

acatgtacag ggaggggtcc tgataactgt atccaatgtg cacactacat agatggtcct      840

cactgtgtaa agacgtgccc cgccggagta atgggtgaaa acaacaccct cgtgtggaag      900

tacgccgatg ccgggcatgt ctgtcatttg tgtcatccca actgcacata tggctgtacc      960

ggtcctggat tggagggctg tccaacaaac gggccgaaaa taccgagtat cgcaacaggc     1020

atggtgggag cacttttgct tctcctcgtt gtcgccctgg gcatcggctt gttcatgtga     1080


<210>  81
<211>  904
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  miR155 3 WPRE

<400>  81
ttcgagcatc ttaccgccat ttattcccat atttgttctg tttttcttga tttgggtata       60

catttaaatg ttaataaaac aaaatggtgg ggcaatcatt tacattttat gggatatgta      120

attactagtt caggtgtatt gccacaagac aaacatgtta agaaactttc ccgttattta      180

cgctctgttc ctgttaatca acctctggat tacaaaattt gtgaaagatt gactgatatt      240

cttaactatg ttgctccttt tacgctgtgt ggatatgctg ctttaatgcc tctgtatcat      300

gctattgctt cccgtacggc tttcgttttc tcctccttgt ataaatcctg gttgctgtct      360

ctttatgagg agttgtggcc cgttgtccgt caacgtggcg tggtgtgctc tgtgtttgct      420

gacgcaaccc ccactggctg gggcattgcc accacctgtc aactcctttc tgggactttc      480

gctttccccc tcccgatcgc cacggcagaa ctcatcgccg cctgccttgc ccgctgctgg      540

acaggggcta ggttgctggg cactgataat tccgtggtgt tgtcggggaa atcatcgtcc      600

tttccttggc tgctcgcctg tgttgccaac tggatcctgc gcgggacgtc cttctgctac      660

gtcccttcgg ctctcaatcc agcggacctc ccttcccgag gccttctgcc ggttctgcgg      720

cctctcccgc gtcttcgctt tcggcctccg acgagtcgga tctccctttg ggccgcctcc      780

ccgcctgttt cgcctcggcg tccggtccgt gttgcttggt cgtcacctgt gcagaattgc      840

gaaccatgga ttccaccgtg aactttgtct cctggcatgc aaatcgtcaa cttggcatgc      900

caag                                                                   904


<210>  82
<211>  299
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  miR155 3 miR155

<400>  82
ctttatgcct catcctctga gtgctgaagg cttgctgtag gctgtatgct gttaatgcta       60

atcgtgatag gggtttttgc ctccaactga ctcctacata ttagcattaa cagtgtatga      120

tgcctgttac tagcattcac atggaacaaa ttgctgccgt gggaggatga caaagaagca      180

tgagtcaccc tgctggataa acttagactt caggctttat catttttcaa tctgttaatc      240

ataatctggt cactgggatg ttcaaccttc gtgctaagct taacacgagc catagatag       299
